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Aliases for HELLS Gene

Aliases for HELLS Gene

  • Helicase, Lymphoid-Specific 2 3
  • Proliferation-Associated SNF2-Like Protein 2 3 4
  • SWI/SNF2-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 6 3 4
  • SMARCA6 3 4
  • PASG 3 4
  • LSH 3 6
  • SWI/SNF2-Related, Matrix-Associated, Actin-Dependent Regulator Of Chromatin, Subfamily A, Member 6 3
  • Actin-Dependent Regulator Of Chromatin 2
  • Lymphoid-Specific Helicase 3
  • Matrix-Associated 2
  • SWI/SNF2-Related 2
  • Subfamily A 2
  • EC 3.6.4.- 4
  • Nbla10143 3
  • Member 6 2
  • EC 3.6.1 63

External Ids for HELLS Gene

Previous GeneCards Identifiers for HELLS Gene

  • GC10P095198
  • GC10P095539
  • GC10P096436
  • GC10P095970
  • GC10P096295
  • GC10P096261
  • GC10P089932
  • GC10P096305

Summaries for HELLS Gene

Entrez Gene Summary for HELLS Gene

  • This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014]

GeneCards Summary for HELLS Gene

HELLS (Helicase, Lymphoid-Specific) is a Protein Coding gene. Diseases associated with HELLS include rothmund-thomson syndrome. Among its related pathways are PEDF Induced Signaling and BRCA1 Pathway. GO annotations related to this gene include chromatin binding and helicase activity.

UniProtKB/Swiss-Prot for HELLS Gene

  • Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).

Gene Wiki entry for HELLS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HELLS Gene

Genomics for HELLS Gene

Regulatory Elements for HELLS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HELLS Gene

Start:
94,501,434 bp from pter
End:
94,613,905 bp from pter
Size:
112,472 bases
Orientation:
Plus strand

Genomic View for HELLS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HELLS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HELLS Gene

Proteins for HELLS Gene

  • Protein details for HELLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRZ9-HELLS_HUMAN
    Recommended name:
    Lymphoid-specific helicase
    Protein Accession:
    Q9NRZ9
    Secondary Accessions:
    • B2RB41
    • Q3LID1
    • Q6I7N7
    • Q76H76
    • Q76H77
    • Q76H78
    • Q76H79
    • Q76H80
    • Q76H81
    • Q7Z397
    • Q7Z5X2
    • Q8N6P4
    • Q9H4P5

    Protein attributes for HELLS Gene

    Size:
    838 amino acids
    Molecular mass:
    97074 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG01987.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH29381.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH30963.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH31004.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HELLS Gene

neXtProt entry for HELLS Gene

Proteomics data for HELLS Gene at MOPED

Selected DME Specific Peptides for HELLS Gene

Post-translational modifications for HELLS Gene

  • Ubiquitination at Lys74, Lys80, Lys204, Lys731, and Lys753
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HELLS (HELLS)

Domains for HELLS Gene

Protein Domains for HELLS Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRZ9

UniProtKB/Swiss-Prot:

HELLS_HUMAN :
  • Q9NRZ9
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with HELLS: view

No data available for Gene Families for HELLS Gene

Function for HELLS Gene

Molecular function for HELLS Gene

GENATLAS Biochemistry:
helicase lymphoid specific,expressed in early thymocytes and testis,SNF2/RAD54 family potentially involved in DNA repair,homologous to S cerivisiae YFK8
UniProtKB/Swiss-Prot Function:
Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).
UniProtKB/Swiss-Prot Induction:
By concanavalin-A in peripheral blood leukocytes.

Enzyme Numbers (IUBMB) for HELLS Gene

Gene Ontology (GO) - Molecular Function for HELLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 22157815
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HELLS: view
genes like me logo Genes that share phenotypes with HELLS: view

Animal Models for HELLS Gene

MGI Knock Outs for HELLS:

Animal Model Products

CRISPR Products

No data available for Transcription Factor Targeting and HOMER Transcription for HELLS Gene

Localization for HELLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for HELLS Gene

Nucleus. Note=Closely associated with pericentric heterochromatin. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HELLS Gene COMPARTMENTS Subcellular localization image for HELLS gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for HELLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region ISS --
GO:0005634 nucleus IEA --
GO:0005721 pericentric heterochromatin ISS --
genes like me logo Genes that share ontologies with HELLS: view

Pathways for HELLS Gene

genes like me logo Genes that share pathways with HELLS: view

Pathways by source for HELLS Gene

1 Cell Signaling Technology pathway for HELLS Gene
1 BioSystems pathway for HELLS Gene

Gene Ontology (GO) - Biological Process for HELLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001655 urogenital system development --
GO:0006306 DNA methylation --
GO:0006342 chromatin silencing --
GO:0006346 methylation-dependent chromatin silencing ISS --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HELLS: view

Compounds for HELLS Gene

(56) Novoseek inferred chemical compound relationships for HELLS Gene

Compound -log(P) Hits PubMed IDs
atp 72.9 97
8-hydroxyadenine 49.5 1
benzo(c)phenanthrene 40.3 3
amp-pnp 39.7 1
methylmethanesulfonate 38.9 4
genes like me logo Genes that share compounds with HELLS: view

Transcripts for HELLS Gene

Unigene Clusters for HELLS Gene

Helicase, lymphoid-specific:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HELLS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HELLS Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a ·
SP1: -
SP2:
SP3: - - - - -
SP4: -
SP5:
SP6: - - - - - - -
SP7: -
SP8:
SP9:

ExUns: 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for HELLS Gene

GeneLoc Exon Structure for
HELLS
ECgene alternative splicing isoforms for
HELLS

Expression for HELLS Gene

mRNA expression in normal human tissues for HELLS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for HELLS Gene

This gene is overexpressed in Breast (41.0) and Tlymphocyte (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HELLS Gene

SOURCE GeneReport for Unigene cluster for HELLS Gene Hs.655830

mRNA Expression by UniProt/SwissProt for HELLS Gene

Q9NRZ9-HELLS_HUMAN
Tissue specificity: Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias.
genes like me logo Genes that share expressions with HELLS: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for HELLS Gene

Orthologs for HELLS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HELLS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HELLS 35
  • 91.75 (n)
  • 94.13 (a)
HELLS 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HELLS 35
  • 92.35 (n)
  • 94.98 (a)
HELLS 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hells 35
  • 89.36 (n)
  • 91.35 (a)
Hells 16
Hells 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HELLS 35
  • 99.74 (n)
  • 99.77 (a)
HELLS 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HELLS 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HELLS 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves HELLS 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HELLS 36
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sbcb65 35
hells 36
  • 64 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL098C 35
  • 52.36 (n)
  • 47.41 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E04159g 35
  • 54.42 (n)
  • 48.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IRC5 35
  • 53.68 (n)
  • 47.96 (a)
IRC5 36
  • 35 (a)
OneToOne
IRC5 38
barley
(Hordeum vulgare)
Liliopsida Hv.2667 35
wheat
(Triticum aestivum)
Liliopsida Ta.23819 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
CSA.5063 36
  • 48 (a)
OneToMany
Species with no ortholog for HELLS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • worm (Caenorhabditis elegans)

Evolution for HELLS Gene

ENSEMBL:
Gene Tree for HELLS (if available)
TreeFam:
Gene Tree for HELLS (if available)

Paralogs for HELLS Gene

genes like me logo Genes that share paralogs with HELLS: view

No data available for Paralogs for HELLS Gene

Variants for HELLS Gene

Sequence variations from dbSNP and Humsavar for HELLS Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs768988 -- 94,590,813(-) AATGG(A/G)AATCA intron-variant
rs962234 -- 94,583,866(-) GAACA(A/G)GACAA intron-variant
rs1048196 -- 94,602,019(+) ATGCT(C/T)TCTGT utr-variant-3-prime
rs1326838 -- 94,594,003(+) GGAGT(C/T)TTGCT intron-variant
rs1326839 -- 94,601,003(+) TGTCT(A/G)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HELLS Gene

Variant ID Type Subtype PubMed ID
nsv517681 CNV Gain 19592680

Relevant External Links for HELLS Gene

HapMap Linkage Disequilibrium report
HELLS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HELLS Gene

Disorders for HELLS Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HELLS Gene in MalaCards »

(1) Diseases for HELLS Gene including...

(43) Novoseek inferred disease relationships for HELLS Gene

Disease -log(P) Hits PubMed IDs
werner syndrome 94.7 43
bloom syndrome 92.4 21
rothmund-thomson syndrome 90 8
cockayne syndrome 81.5 11
trichothiodystrophy 80.4 4

Relevant External Links for HELLS

Genetic Association Database (GAD)
HELLS
Human Genome Epidemiology (HuGE) Navigator
HELLS
genes like me logo Genes that share disorders with HELLS: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for HELLS Gene

Publications for HELLS Gene

  1. Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia. (PMID: 10910076) Lee D.W. … Arceci R.J. (Cancer Res. 2000) 2 3 4 23
  2. Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh). (PMID: 9878251) Geiman T.M. … Muegge K. (Genomics 1998) 2 3 23
  3. Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts. (PMID: 19561196) Zhou R. … Tong T. (Nucleic Acids Res. 2009) 3 23
  4. Stable knockdown of PASG enhances DNA demethylation but does not accelerate cellular senescence in TIG-7 human fibroblasts. (PMID: 18948754) Suzuki T. … Arceci R.J. (Epigenetics 2008) 3 23
  5. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PMID: 19064572) Palmieri R.T. … . (Cancer Epidemiol. Biomarkers Prev. 2008) 3 48

Products for HELLS Gene

Sources for HELLS Gene

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