External Ids for HELB Gene
Previous GeneCards Identifiers for HELB Gene
This gene encodes a DNA-dependent ATPase which catalyzes the unwinding of DNA necessary for DNA replication, repair, recombination, and transcription. This gene is thought to function specifically during the S phase entry of the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
GeneCards Summary for HELB Gene
HELB (Helicase (DNA) B) is a Protein Coding gene. Diseases associated with HELB include atypical lipomatous tumor. GO annotations related to this gene include poly(A) RNA binding and ATP-dependent DNA helicase activity.
UniProtKB/Swiss-Prot for HELB Gene
Unwinds duplex DNA with 5-3 polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress.