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Aliases for HELB Gene

Aliases for HELB Gene

  • Helicase (DNA) B 2 3
  • HDHB 3 4 6
  • DNA Helicase B 3
  • EC 3.6.4.12 4

External Ids for HELB Gene

Summaries for HELB Gene

Entrez Gene Summary for HELB Gene

  • This gene encodes a DNA-dependent ATPase which catalyzes the unwinding of DNA necessary for DNA replication, repair, recombination, and transcription. This gene is thought to function specifically during the S phase entry of the cell cycle. [provided by RefSeq, Mar 2012]

GeneCards Summary for HELB Gene

HELB (Helicase (DNA) B) is a Protein Coding gene. GO annotations related to this gene include ATP-dependent 5-3 DNA helicase activity and single-stranded DNA-dependent ATP-dependent DNA helicase activity.

UniProtKB/Swiss-Prot for HELB Gene

  • Unwinds duplex DNA with 5-3 polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HELB Gene

Genomics for HELB Gene

Genomic Location for HELB Gene

Start:
66,302,545 bp from pter
End:
66,347,645 bp from pter
Size:
45,101 bases
Orientation:
Plus strand

Genomic View for HELB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HELB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HELB Gene

Regulatory Elements for HELB Gene

Proteins for HELB Gene

  • Protein details for HELB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG08-HELB_HUMAN
    Recommended name:
    DNA helicase B
    Protein Accession:
    Q8NG08
    Secondary Accessions:
    • A8K4C9
    • Q4G0T2
    • Q9H7L5

    Protein attributes for HELB Gene

    Size:
    1087 amino acids
    Molecular mass:
    123252 Da
    Quaternary structure:
    • Binds to RPA1; this interaction promotes HELB recruitment to chromatin following DNA damage. Interacts with at least two subunits of pol-prim.
    SequenceCaution:
    • Sequence=BAB15754.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for HELB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HELB Gene

Proteomics data for HELB Gene at MOPED

Post-translational modifications for HELB Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys254

Other Protein References for HELB Gene

No data available for DME Specific Peptides for HELB Gene

Domains for HELB Gene

Protein Domains for HELB Gene

genes like me logo Genes that share domains with HELB: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HELB Gene

Function for HELB Gene

Molecular function for HELB Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by salt concentration greater than 100 mM. Uses either magnesium or manganese ions to support helicase activity. Binds strongly to single-stranded DNA in the absence of ATP but dissociates readily in the presence of 1 mM ATP.
UniProtKB/Swiss-Prot Function: Unwinds duplex DNA with 5-3 polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress.

Enzyme Numbers (IUBMB) for HELB Gene

Gene Ontology (GO) - Molecular Function for HELB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004003 ATP-dependent DNA helicase activity --
GO:0004004 NOT ATP-dependent RNA helicase activity IBA --
GO:0005524 ATP binding IEA --
GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity IDA 12181327
GO:0043141 ATP-dependent 5-3 DNA helicase activity IDA 12181327
genes like me logo Genes that share ontologies with HELB: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HELB Gene

Localization for HELB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HELB Gene

Note=Preferentially during S phase, recruited to chromatin following DNA damage induced by UV irradiation, or camptothecin or hydroxyurea treatment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HELB Gene COMPARTMENTS Subcellular localization image for HELB gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HELB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005658 colocalizes_with alpha DNA polymerase:primase complex IDA 12181327
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with HELB: view

Pathways for HELB Gene

SuperPathways for HELB Gene

No Data Available

Gene Ontology (GO) - Biological Process for HELB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IMP 12181327
GO:0006261 DNA-dependent DNA replication --
GO:0006269 DNA replication, synthesis of RNA primer IDA 12181327
GO:0006396 NOT RNA processing IBA --
GO:0032508 DNA duplex unwinding IEA --
genes like me logo Genes that share ontologies with HELB: view

No data available for Pathways by source for HELB Gene

Compounds for HELB Gene

(2) HMDB Compounds for HELB Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
genes like me logo Genes that share compounds with HELB: view

Transcripts for HELB Gene

mRNA/cDNA for HELB Gene

Unigene Clusters for HELB Gene

Helicase (DNA) B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HELB Gene

No ASD Table

Relevant External Links for HELB Gene

GeneLoc Exon Structure for
HELB
ECgene alternative splicing isoforms for
HELB

Expression for HELB Gene

mRNA expression in normal human tissues for HELB Gene

mRNA differential expression in normal tissues according to GTEx for HELB Gene

This gene is overexpressed in Whole Blood (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HELB Gene

SOURCE GeneReport for Unigene cluster for HELB Gene Hs.505941

mRNA Expression by UniProt/SwissProt for HELB Gene

Q8NG08-HELB_HUMAN
Tissue specificity: Highly expressed in testis and thymus and weakly in liver, spleen, kidney and brain.
genes like me logo Genes that share expressions with HELB: view

Orthologs for HELB Gene

This gene was present in the common ancestor of chordates.

Orthologs for HELB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HELB 36
  • 99.48 (n)
  • 99.45 (a)
HELB 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HELB 36
  • 82.62 (n)
  • 76.26 (a)
HELB 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HELB 36
  • 78.39 (n)
  • 71.87 (a)
HELB 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Helb 36
  • 73.06 (n)
  • 68.46 (a)
Helb 16
Helb 37
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HELB 37
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 70 (a)
OneToMany
-- 37
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Helb 36
  • 73.05 (n)
  • 67.14 (a)
chicken
(Gallus gallus)
Aves HELB 36
  • 59.08 (n)
  • 49.65 (a)
HELB 37
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HELB 37
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia helb 36
  • 53.87 (n)
  • 44.79 (a)
zebrafish
(Danio rerio)
Actinopterygii helb 36
  • 48.79 (n)
  • 41.06 (a)
helb 37
  • 34 (a)
OneToOne
Species with no ortholog for HELB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HELB Gene

ENSEMBL:
Gene Tree for HELB (if available)
TreeFam:
Gene Tree for HELB (if available)

Paralogs for HELB Gene

No data available for Paralogs for HELB Gene

Variants for HELB Gene

Sequence variations from dbSNP and Humsavar for HELB Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1168289 -- 66,303,107(+) TTTTT(A/T)AAAAT intron-variant
rs1168290 -- 66,338,678(+) AAAAA(A/C)CAAAC intron-variant, downstream-variant-500B
rs1168291 -- 66,338,708(+) TTGTA(C/T)TTTTA intron-variant, downstream-variant-500B
rs1168292 -- 66,338,880(+) TGCTG(C/T)CTGGG intron-variant, downstream-variant-500B
rs1168293 -- 66,340,124(+) ttttg(A/G)gtata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HELB Gene

Variant ID Type Subtype PubMed ID
nsv899216 CNV Gain 21882294

Relevant External Links for HELB Gene

HapMap Linkage Disequilibrium report
HELB

Disorders for HELB Gene

No disorders were found for HELB Gene.

No data available for UniProtKB/Swiss-Prot for HELB Gene

Publications for HELB Gene

  1. A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication. (PMID: 12181327) Taneja P. … Fanning E. (J. Biol. Chem. 2002) 2 3 4
  2. Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress. (PMID: 22194613) Guler G.D. … Fanning E. (J. Biol. Chem. 2012) 3 4
  3. Proteomic analysis reveals a FANCA-modulated neddylation pathway involved in CXCR5 membrane targeting and cell mobility. (PMID: 25015289) Renaudin X. … Rosselli F. (J. Cell. Sci. 2014) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PMID: 17525332) Matsuoka S. … Elledge S.J. (Science 2007) 4

Products for HELB Gene

Sources for HELB Gene

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