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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HEG1 Gene

protein-coding   GIFtS: 46
GCID: GC03M124684

HEG homolog 1 (zebrafish)
 Explore 3 diseases affiliated with
HEG1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HEG1    

Aliases
for HEG1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
HEG Homolog 1 (Zebrafish)1 2
HEG1 2
KIAA12371 3
MST1122
MSTP1122
Protein HEG Homolog 12

External Ids:    HGNC: 292271   Entrez Gene: 574932   Ensembl: ENSG000001737067   OMIM: 6141825   UniProtKB: Q9ULI33   

Export aliases for HEG1 gene to outside databases

Previous GC identifers: GC03M126171 GC03M122058


Summaries
for HEG1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: HEG1_HUMAN, Q9ULI3
Function: Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation
and integrity May act through the stabilization of endothelial cell junctions (By similarity)




Genomic Views
for HEG1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HEG1 gene promoter:
         STAT1   p53   E47   Evi-1   FOXL1   HFH-1   c-Myb   FOXO1a   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HEG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.2   Ensembl cytogenetic band:  3q21.2   HGNC cytogenetic band: 3q21.2

HEG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HEG1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M124684:  view genomic region     (about GC identifiers)

Start:
 124,684,554 bp from pter      End:
 124,774,802 bp from pter
Size:
 90,249 bases      Orientation:
 minus strand

Proteins
for HEG1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HEG1_HUMAN, Q9ULI3 (See protein sequence)
Recommended Name: Protein HEG homolog 1 precursor  
Size: 1381 amino acids; 147461 Da
Subunit: Interacts with CCM2 and KRIT1; KRIT1 markedly facilitates interaction with CCM2
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Cell junction (By
similarity)
Subcellular location: Isoform 2: Secreted (Potential)
Sequence caution: Sequence=AAH67235.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC11336.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for HEG1:
3U7D (3D)    
Secondary accessions: Q6NX66 Q8NC40 Q9BSV0
Alternative splicing: 2 isoforms:  Q9ULI3-1   Q9ULI3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HEG1: NX_Q9ULI3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULI3

    • HEG1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065784.1  
    ENSEMBL proteins: 
     ENSP00000311502   ENSP00000417648   ENSP00000417494  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: HEG1
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    Novus Biologicals HEG1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HEG1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005911cell-cell junction IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ----
    GO:0016021integral to membrane IEA--


    HEG1 for ontologies           About GeneDecksing



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    Uscn Antibodies for HEG1
    Search ThermoFisher Antibodies for HEG1

    Assay Products for HEG1: 
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    Uscn ELISAs and CLIAs for HEG1

    Protein Domains /
    Families
    for HEG1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HEG1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR001881 EGF-like_Ca-bd
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry Q9ULI3

    ProtoNet protein and cluster: Q9ULI3

    1 Blocks protein family: IPB001881 EGF-like calcium-binding

    UniProtKB/Swiss-Prot: HEG1_HUMAN, Q9ULI3
    Similarity: Contains 2 EGF-like domains


    Function
    for HEG1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HEG1_HUMAN, Q9ULI3
    Function: Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation
    and integrity May act through the stabilization of endothelial cell junctions (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: HEG1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HEG1
    8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate HEG1 (see all 112):
    hsa-miR-520e hsa-miR-193a-3p hsa-miR-642a hsa-miR-106a hsa-miR-128 hsa-miR-374a hsa-miR-519a hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEG1 (see all 3)
    OriGene shRNA RFP: HEG1
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEG1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HEG1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEG1 (see all 2)
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    Browse Sino Biological Human cDNA Clones
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HEG1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HEG1
    Search LifeMap BioReagents cell lines for HEG1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEG1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----


    HEG1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for HEG1:
     Decreased influenza A/WSN/33 r  Decreased viability with pacli 

    Animal Models:
         Mouse knock-out Heg1tm1Mlkn for HEG1
         10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Heg1):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size 
     homeostasis/metabolism  immune system  mortality/aging  muscle  respiratory system 

    HEG1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HEG1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HEG1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for HEG1 (ENSP000003115024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRIT1ENSP000003446684STRING: ENSP00000344668
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001885endothelial cell development ----
    GO:0001886endothelial cell morphogenesis IEA--
    GO:0001944vasculature development ----


    HEG1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HEG1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HEG1
    Search CenterWatch for drugs/clinical trials and news about HEG1 

    Transcripts
    for HEG1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HEG1 gene: 
    NM_020733.1  

    Unigene Cluster for HEG1:

    HEG homolog 1 (zebrafish)
    Hs.477420  [show with all ESTs]
    Unigene Representative Sequence: NM_020733
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311127(uc003ehr.4 uc003ehs.4 uc011bke.2) ENST00000487661
    ENST00000480667 ENST00000482699 ENST00000488654 ENST00000477536

    miRNA
    Products:             		 OriGene 3'-UTR Clone: HEG1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HEG1
    8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate HEG1 (see all 112):
    hsa-miR-520e hsa-miR-193a-3p hsa-miR-642a hsa-miR-106a hsa-miR-128 hsa-miR-374a hsa-miR-519a hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEG1 (see all 3)
    OriGene shRNA RFP: HEG1
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEG1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEG1 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEG1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HEG1 (NM_020733)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HEG1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HEG1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEG1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HEG1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEG1

    Additional cDNA sequence: 

    AB033063.2 AF173887.1 AK074987.1 BC004539.2 BC014053.2 BC047661.1 BC067235.1 

    9 DOTS entries:

    DT.91757998  DT.315979  DT.415704  DT.97787859  DT.120909136  DT.95104409  DT.100820812  DT.92034236 
    DT.92034235 

    1 AceView cDNA sequence:

    BF849902 

    GeneLoc Exon Structure


    Expression
    for HEG1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HEG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTCCTGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HEG1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HEG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HEG1

    SOURCE GeneReport for Unigene cluster: Hs.477420
        SABiosciences Custom PCR Arrays for HEG1
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEG1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEG1

    Orthologs
    for HEG1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HEG1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Heg11 , 5 HEG homolog 1 (zebrafish)1, 5 73.41(n)1
    66.45(a)1    		   16 (24.17 cM)5
    774461  NM_175256.51  NP_780465.41 
     336844665 
    chicken
    (Gallus gallus)    		 Aves HEG11 HEG homolog 1 (zebrafish) 57.04(n)
    54.22(a)    		   424257  XM_422104.3  XP_422104.3 
    lizard
    (Anolis carolinensis)    		 Reptilia HEG16
    		 --
    		 45(a)
    		 1 ↔ 1
    		 1(78058801-78082218)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.294002 Danio rerio heart of glass transmembrane isoform (heg) more 71.83(n)    AY507660.1 


    ENSEMBL Gene Tree for HEG1 (if available)
    TreeFam Gene Tree for HEG1 (if available) 

    Paralogs
    for HEG1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for HEG1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1634 NCBI SNPs in HEG1 are shown (see all 1634)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs781774941,2
    		--124684117(+) TTCACG/CAATGT 1 -- ds50011Minor allele frequency- C:0.01EA 120
    rs1491494611,2
    		--124684149(+) TCCCTC/TGGCCA 1 -- ds50010--------
    rs1432170961,2
    		--124684194(+) AGTTCG/TGCAGA 1 -- ds50010--------
    rs1820868691,2
    		--124684263(+) TTGGCA/GTGGAA 1 -- ds50010--------
    rs713258101,2
    		C,--124684303(+) TGTAAG/ATATCT 1 -- ds50013Minor allele frequency- A:0.04NA 124
    rs1483258731,2
    		--124684312(+) CTGAAC/TTGGTC 1 -- ds50010--------
    rs168362991,2
    		C,F,H,--124684323(+) ACTTAT/CGGTCT 1 -- ds500117Minor allele frequency- C:0.09NA NS EA WA CSA 1318
    rs1854467941,2
    		--124684357(+) GTGCTA/GTATCT 1 -- ds50010--------
    rs1163260111,2
    		C,F,--124684397(+) TTGTCC/TATCCA 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1156905091,2
    		F,--124684448(+) GAATAC/TAGAAA 1 -- ds50011Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for HEG1 (124684554 - 124774802 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for HEG1
         1 CNV: 47990
         1 Indel: 68442

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEG1
    DNA2.0 Custom Variant and Variant Library Synthesis for HEG1

    Disorders / Diseases
    for HEG1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HEG1 for disorders           About GeneDecksing

    OMIM gene information: 614182    OMIM disorders: --

    3 diseases for HEG1:    About MalaCards
    cavernous malformation    cerebral cavernous malformations    cerebritis

    Human Genome Epidemiology (HuGE) Navigator: HEG1 (2 documents)

    Export disorders for HEG1 gene to outside databases

    Publications
    for HEG1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HEG1 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with HEG1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. Structural basis of the junctional anchorage of the cerebral cavernous malformations complex. (PubMed id 23007647)2 Gingras A.R.... Ginsberg M.H. (2012)
    3. Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD. (PubMed id 22171320)2 Halim A.... Larson G. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
    7. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)2 Liu T.... Smith R.D. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. heart of glass regulates the concentric growth of the heart in zebrafish. (PubMed id 14680629)1 Mably J.D....Fishman M.C. (2003)

    External Searches for HEG1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HEG1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57493 HGNC: 29227 AceView: HEG.1 Ensembl:ENSG00000173706 euGenes: HUgn57493
    ECgene: HEG1 H-InvDB: HEG1

    Other Databases showing HEG1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1237

    Specialized Databases showing HEG1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HEG1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HEG1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HEG1 gene:
    Search GeneIP for patents involving HEG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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