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Aliases for HECW2 Gene

Aliases for HECW2 Gene

  • HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 2 3 5
  • HECT, C2 And WW Domain-Containing Protein 2 3 4
  • NEDD4-Like E3 Ubiquitin-Protein Ligase 2 3 4
  • NEDL2 3 4
  • NEDD4-Related E3 Ubiquitin Ligase NEDL2 3
  • EC 6.3.2.- 4
  • KIAA1301 4
  • EC 6.3.2 63

External Ids for HECW2 Gene

Previous GeneCards Identifiers for HECW2 Gene

  • GC02M196890
  • GC02M196772
  • GC02M197064
  • GC02M188916

Summaries for HECW2 Gene

GeneCards Summary for HECW2 Gene

HECW2 (HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is AREL1.

UniProtKB/Swiss-Prot for HECW2 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECW2 Gene

Genomics for HECW2 Gene

Regulatory Elements for HECW2 Gene

Enhancers for HECW2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HECW2 on UCSC Golden Path with GeneCards custom track

Promoters for HECW2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HECW2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HECW2 Gene

196,194,370 bp from pter
196,593,692 bp from pter
399,323 bases
Minus strand

Genomic View for HECW2 Gene

Genes around HECW2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HECW2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HECW2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HECW2 Gene

Proteins for HECW2 Gene

  • Protein details for HECW2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase HECW2
    Protein Accession:
    Secondary Accessions:
    • B8ZZB4
    • Q17RT5
    • Q68DF8
    • Q9NPS9

    Protein attributes for HECW2 Gene

    1572 amino acids
    Molecular mass:
    175769 Da
    Quaternary structure:
    • Interacts with TP73.
    • Sequence=BAA92539.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HECW2 Gene

    Alternative splice isoforms for HECW2 Gene


neXtProt entry for HECW2 Gene

Proteomics data for HECW2 Gene at MOPED

Selected DME Specific Peptides for HECW2 Gene

Post-translational modifications for HECW2 Gene

  • Ubiquitination at Lys 183
  • Modification sites at PhosphoSitePlus

Other Protein References for HECW2 Gene

Domains & Families for HECW2 Gene

Gene Families for HECW2 Gene

Protein Domains for HECW2 Gene

Suggested Antigen Peptide Sequences for HECW2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Contains 1 C2 domain.
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Contains 2 WW domains.
genes like me logo Genes that share domains with HECW2: view

Function for HECW2 Gene

Molecular function for HECW2 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.

Enzyme Numbers (IUBMB) for HECW2 Gene

Gene Ontology (GO) - Molecular Function for HECW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with HECW2: view
genes like me logo Genes that share phenotypes with HECW2: view

Animal Models for HECW2 Gene

MGI Knock Outs for HECW2:

Animal Model Products

  • Taconic Biosciences Mouse Models for HECW2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HECW2 Gene

Localization for HECW2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HECW2 Gene


Subcellular locations from

Jensen Localization Image for HECW2 Gene COMPARTMENTS Subcellular localization image for HECW2 gene
Compartment Confidence
mitochondrion 3
cytosol 2
golgi apparatus 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for HECW2 Gene

Pathways & Interactions for HECW2 Gene

genes like me logo Genes that share pathways with HECW2: view

UniProtKB/Swiss-Prot Q9P2P5-HECW2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for HECW2 Gene


No data available for SIGNOR curated interactions for HECW2 Gene

Drugs & Compounds for HECW2 Gene

No Compound Related Data Available

Transcripts for HECW2 Gene

Unigene Clusters for HECW2 Gene

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HECW2 Gene

No ASD Table

Relevant External Links for HECW2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HECW2 Gene

mRNA expression in normal human tissues for HECW2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HECW2 Gene

This gene is overexpressed in Lung (x4.5).

Protein differential expression in normal tissues from HIPED for HECW2 Gene

This gene is overexpressed in Serum (63.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HECW2 Gene

SOURCE GeneReport for Unigene cluster for HECW2 Gene Hs.654742

mRNA Expression by UniProt/SwissProt for HECW2 Gene

Tissue specificity: Predominantly expressed in adult brain, lung and heart.
genes like me logo Genes that share expression patterns with HECW2: view

Primer Products

No data available for Protein tissue co-expression partners for HECW2 Gene

Orthologs for HECW2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HECW2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HECW2 35
  • 93.97 (n)
  • 99.34 (a)
HECW2 36
  • 70 (a)
(Canis familiaris)
Mammalia HECW2 35
  • 88.11 (n)
  • 92.59 (a)
HECW2 36
  • 83 (a)
(Mus musculus)
Mammalia Hecw2 35
  • 89.41 (n)
  • 95.23 (a)
Hecw2 16
Hecw2 36
  • 95 (a)
(Pan troglodytes)
Mammalia HECW2 35
  • 99.45 (n)
  • 99.55 (a)
HECW2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hecw2 35
  • 88.87 (n)
  • 94.66 (a)
(Monodelphis domestica)
Mammalia HECW2 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia HECW2 36
  • 81 (a)
(Gallus gallus)
Aves HECW2 35
  • 78.82 (n)
  • 87.12 (a)
HECW2 36
  • 87 (a)
(Anolis carolinensis)
Reptilia HECW2 36
  • 84 (a)
(Danio rerio)
Actinopterygii hecw2 35
  • 70.61 (n)
  • 78.57 (a)
HECW2 (2 of 2) 36
  • 67 (a)
hecw2a 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42797 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea hecw-1 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1682 36
  • 68 (a)
Species with no ortholog for HECW2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HECW2 Gene

Gene Tree for HECW2 (if available)
Gene Tree for HECW2 (if available)

Paralogs for HECW2 Gene

Paralogs for HECW2 Gene

(9) SIMAP similar genes for HECW2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HECW2: view

Variants for HECW2 Gene

Sequence variations from dbSNP and Humsavar for HECW2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs724276 -- 196,318,294(+) ATTAA(A/G)TCCCA intron-variant
rs724277 -- 196,317,964(+) ACTTA(A/G)TTGAC intron-variant
rs729145 -- 196,232,928(-) AGAGG(G/T)GACTC intron-variant
rs745031 -- 196,233,059(-) TACCC(C/T)GCTGT intron-variant
rs1563377 -- 196,226,303(+) CCACC(A/G)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HECW2 Gene

Variant ID Type Subtype PubMed ID
nsv875693 CNV Loss 21882294
nsv3095 CNV Insertion 18451855
esv2721335 CNV Deletion 23290073
nsv507058 CNV Insertion 20534489
nsv834504 CNV Loss 17160897
esv2671294 CNV Deletion 23128226
esv269040 CNV Insertion 20981092

Variation tolerance for HECW2 Gene

Residual Variation Intolerance Score: 4.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HECW2 Gene

Disorders for HECW2 Gene

Relevant External Links for HECW2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HECW2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HECW2 Gene

Publications for HECW2 Gene

  1. A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity. (PMID: 12890487) Miyazaki K. … Nakagawara A. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23 67
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  3. Novel functions and targets of miR-944 in human cervical cancer cells. (PMID: 25156441) Xie H. … Lui W.O. (Int. J. Cancer 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3

Products for HECW2 Gene

Sources for HECW2 Gene