Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HECW2 Gene

protein-coding   GIFtS: 51
GCID: GC02M197064

HECT, C2 and WW domain containing E3 ubiquitin protein ligase...
 Explore 2 diseases affiliated with
HECW2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HECW2    

Aliases
for HECW2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 21 2     E3 Ubiquitin-Protein Ligase HECW22
NEDL21 2 3     NEDD4-Related E3 Ubiquitin Ligase NEDL22
KIAA13011 3     EC 6.3.2.-3
HECT, C2 And WW Domain-Containing Protein 22 3     EC 6.3.28
NEDD4-Like E3 Ubiquitin-Protein Ligase 22 3     

External Ids:    HGNC: 298531   Entrez Gene: 575202   Ensembl: ENSG000001384117   UniProtKB: Q9P2P53   

Export aliases for HECW2 gene to outside databases

Previous GC identifers: GC02M196890 GC02M196772 GC02M188916


Summaries
for HECW2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: HECW2_HUMAN, Q9P2P5
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance
activation of transcription by TP73




Genomic Views
for HECW2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HECW2 gene promoter:
         TBP   C/EBPbeta   AP-1   POU3F1   HEN1   Egr-2   FOXJ2 (long isoform)   FOXO1a   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HECW2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HECW2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HECW2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.3   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q32.3

HECW2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HECW2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M197064:  view genomic region     (about GC identifiers)

Start:
 197,063,977 bp from pter      End:
 197,458,416 bp from pter
Size:
 394,440 bases      Orientation:
 minus strand

Proteins
for HECW2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HECW2_HUMAN, Q9P2P5 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase HECW2  
Size: 1572 amino acids; 175769 Da
Subunit: Interacts with TP73
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAA92539.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for HECW2:
2LFE (3D)    
Secondary accessions: B8ZZB4 Q17RT5 Q68DF8 Q9NPS9
Alternative splicing: 2 isoforms:  Q9P2P5-1   Q9P2P5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HECW2: NX_Q9P2P5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P2P5

    • 4/6 DME Specific Peptides for HECW2 (Q9P2P5) (see all 6)
     KNKKEYI  NPYYGLF  RLLQFVTG  RTTTWQRPT 

    HECW2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065811.1  
    ENSEMBL proteins: 
     ENSP00000386775   ENSP00000260983   ENSP00000409918   ENSP00000395770  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HECW2
    OriGene Protein Over-expression Lysate: HECW2
    OriGene Custom Protein Services for HECW2 
    GenScript Custom Purified and Recombinant Proteins Services for HECW2
    Novus Biologicals HECW2 Protein
    Novus Biologicals HECW2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HECW2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IBA--


    HECW2 for ontologies           About GeneDecksing



    HECW2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HECW2 
    GenScript Custom Superior Antibodies Services for HECW2
    Novus Biologicals HECW2 Antibodies
    Search for Antibodies for HECW2 at Abcam  
    Uscn Antibodies for HECW2
    Search ThermoFisher Antibodies for HECW2

    Assay Products for HECW2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HECW2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HECW2

    Protein Domains /
    Families
    for HECW2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HECW2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR018029 C2_membr_targeting
     IPR000569 HECT
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR001202 WW_Rsp5_WWP
     IPR000008 C2_Ca-dep

    Graphical View of Domain Structure for InterPro Entry Q9P2P5

    ProtoNet protein and cluster: Q9P2P5

    2 Blocks protein families:
    IPB000008 C2 domain
    IPB000569 HECT domain (Ubiquitin-protein ligase)


    UniProtKB/Swiss-Prot: HECW2_HUMAN, Q9P2P5
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 2 WW domains


    Function
    for HECW2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HECW2_HUMAN, Q9P2P5
    Function: E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance
    activation of transcription by TP73

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HECW2
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate HECW2 (see all 58):
    hsa-miR-142-5p hsa-miR-520f hsa-miR-301a hsa-miR-449a hsa-miR-548l hsa-miR-9 hsa-miR-556-3p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: HECW2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HECW2 (see all 7)
    OriGene shRNA RFP: HECW2
    OriGene siRNA: HECW2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HECW2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HECW2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HECW2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HECW2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HECW2 (NM_020760)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HECW2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HECW2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HECW2
    Search LifeMap BioReagents cell lines for HECW2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HECW2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IBA--


    HECW2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HECW2:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for HECW2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitin-Proteasome Dependent Proteolysis
    		Ubiquitin-Proteasome Dependent Proteolysis1.00
    2SMAD Signaling Network
    		SMAD Signaling Network1.00

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HECW2
        SMAD Signaling Network
    Ubiquitin-Proteasome Dependent Proteolysis


    UniProtKB/Swiss-Prot: HECW2_HUMAN, Q9P2P5
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HECW2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for HECW2 (Q9P2P52, 3 ENSP000002609834) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP73O153503, ENSP000003675454I2D: score=2 STRING: ENSP00000367545
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    FBXL15Q9H4692, ENSP000002248624MINT-8298383 STRING: ENSP00000224862
    DVL2O146413I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA--


    HECW2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HECW2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HECW2
    Search CenterWatch for drugs/clinical trials and news about HECW2 

    Transcripts
    for HECW2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HECW2 gene: 
    NM_020760.1  

    Unigene Cluster for HECW2:

    HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
    Hs.654742  [show with all ESTs]
    Unigene Representative Sequence: AB037722
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409111(uc002utl.1) ENST00000260983(uc002utm.1) ENST00000498146
    ENST00000462290 ENST00000452031 ENST00000427457

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HECW2
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate HECW2 (see all 58):
    hsa-miR-142-5p hsa-miR-520f hsa-miR-301a hsa-miR-449a hsa-miR-548l hsa-miR-9 hsa-miR-556-3p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: HECW2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HECW2 (see all 7)
    OriGene shRNA RFP: HECW2
    OriGene siRNA: HECW2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HECW2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HECW2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HECW2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HECW2 (NM_020760)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HECW2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HECW2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HECW2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HECW2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HECW2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HECW2

    Additional cDNA sequence: 

    AB037722.1 AK126991.1 AL390186.1 BC117194.1 BC117198.1 CR749424.1 

    8 DOTS entries:

    DT.410096  DT.121003141  DT.101956651  DT.75125441  DT.102822166  DT.121003136  DT.121003138  DT.65287027 

    24/55 AceView cDNA sequences (see all 55):

    F09383 AA581426 AI991529 BI255575 F09371 F11713 BF665534 T47748 
    AA807184 AI637981 T47747 BX642623 BU561522 BX474524 BM352245 BU852720 
    BV188547 BM351932 AK126991 BU567882 BX117279 CA843303 AA830593 BU852127 

    GeneLoc Exon Structure


    Expression
    for HECW2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HECW2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATACAAGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HECW2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See HECW2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HECW2

    SOURCE GeneReport for Unigene cluster: Hs.654742

    UniProtKB/Swiss-Prot: HECW2_HUMAN, Q9P2P5
    Tissue specificity: Predominantly expressed in adult brain, lung and heart

        SABiosciences Expression via Pathway-Focused PCR Arrays including HECW2: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HECW2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HECW2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HECW2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HECW2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HECW2

    Orthologs
    for HECW2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HECW2 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HECW21 HECT, C2 and WW domain containing E3 ubiquitin protein more 78.97(n)
    87.32(a)    		   424050  XM_421906.3  XP_421906.2 
    lizard
    (Anolis carolinensis)    		 Reptilia HECW26
    		 --
    		 84(a)
    		 1 ↔ 1
    		 GL343280.1(590120-779806)
    zebrafish
    (Danio rerio)    		 Actinopterygii hecw21 HECT, C2 and WW domain containing E3 ubiquitin protein more 67.54(n)
    74.05(a)    		   100331355  XM_003197612.1  XP_003197660.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG427971 CG42797 57.01(n)
    63.25(a)    		   31905  NM_001201643.1  NP_001188572.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea hecw-11 Protein HECW-1 46.18(n)
    36.12(a)    		   175438  NM_065296.2  NP_497697.1 


    ENSEMBL Gene Tree for HECW2 (if available)
    TreeFam Gene Tree for HECW2 (if available) 

    Paralogs
    for HECW2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HECW2 gene
    HACE12  NEDD4L2  WWP22  KIAA03172  SMURF12  HECW12  SMURF22  WWP12  
    NEDD42  ITCH2  
    9 SIMAP similar genes for HECW2 using alignment to 3 protein entries:     HECW2_HUMAN (see all proteins):
    DKFZp564H223    NEDL1    HECW1    SMURF1    HUWE1    SMURF2
    WWP2    ITCH    WWP1

    HECW2 for paralogs           About GeneDecksing



    Genomic Variants
    for HECW2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/99 NCBI SNPs in HECW2 are shown (see all 99)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1382205271,2
    		C,--197103180(+) CTTTC-/TTT   
       CTTTA    TTTTT     		1 -- int10--------
    rs1489523301,2
    		C,--197103187(+) TCTTT-/ATTTTT 1 -- int10--------
    rs1434256111,2
    		C--197105492(+) TGGTA-/AATA  
                GAGTA     		1 -- int10--------
    rs106413621,2
    		C--197113446(+) GAAGAAGA/-TGACA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs114213731,2
    		C,--197114190(+) AAAAGC/-GGGGA 1 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs2002095741,2
    		C,--197116939(+) ATAAT-/AAGGCTTC 1 -- int10--------
    rs671231351,2
    		C--197126746(+) TTATAT/-ATGTA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1864011561,2
    		--197148095(+) GAGAGA/GATACA 1 -- int10--------
    rs351386991,2
    		C,--197154024(+) ACTGT-/GGGAAA 1 -- int11Minor allele frequency- G:0.00NA 2
    rs352779961,2
    		C,--197164898(+) AGACTA/-GGGGT 1 -- int12Minor allele frequency- -:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for HECW2 (197063977 - 197313977 bp, first 250kb of HECW2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HECW2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HECW2
    DNA2.0 Custom Variant and Variant Library Synthesis for HECW2

    Disorders / Diseases
    for HECW2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HECW2 for disorders           About GeneDecksing

    2 diseases for HECW2:    About MalaCards
    liddle syndrome    malaria

    Human Genome Epidemiology (HuGE) Navigator: HECW2 (1 document)

    Export disorders for HECW2 gene to outside databases

    Publications
    for HECW2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HECW2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with HECW2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity. (PubMed id 12890487)1, 2, 3, 9 Miyazaki K....Nakagawara A. (2003)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    External Searches for HECW2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HECW2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57520 HGNC: 29853 AceView: NEDL2 Ensembl:ENSG00000138411 euGenes: HUgn57520
    ECgene: HECW2 H-InvDB: HECW2

    Other Databases showing HECW2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1301

    Specialized Databases showing HECW2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HECW2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HECW2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HECW2 gene:
    Search GeneIP for patents involving HECW2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HECW2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HECW2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HECW2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HECW2  
     OriGene Protein Over-expression Lysate for HECW2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HECW2   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HECW2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HECW2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for HECW2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HECW2   OriGene Custom Protein Services for HECW2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HECW2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HECW2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HECW2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HECW2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HECW2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HECW2
     GenScript Custom Purified and Recombinant Proteins Services for HECW2 GenScript cDNA clones with any tag delivered in your preferred vector for HECW2
     GenScript Custom Assay Services for HECW2 GenScript Custom Superior Antibodies Services for HECW2
     GenScript Custom overexpressing Cell Line Services for HECW2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HECW2 promoter
     Search Chromatin IP Primers for HECW2
     RT2 qPCR Primer Assay in human, mouse, rat HECW2
     GNC Network for HECW2
     SABiosciences PCR Arrays including human, mouse, rat HECW2
     Search Tocris compounds for HECW2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HECW2 antibodies
     HECW2 proteins
     HECW2 lysates
     Search for Antibodies for HECW2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HECW2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HECW2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HECW2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HECW2
     SwitchGear 3'UTR luciferase reporter plasmids for HECW2
     SwitchGear Promoter luciferase reporter plasmids for HECW2
     Search ThermoFisher Antibodies for HECW2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HECW2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      HECW2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4