Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HECW2 Gene

Aliases for HECW2 Gene

  • HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 2 3
  • HECT, C2 And WW Domain-Containing Protein 2 3 4
  • NEDD4-Like E3 Ubiquitin-Protein Ligase 2 3 4
  • NEDL2 3 4
  • NEDD4-Related E3 Ubiquitin Ligase NEDL2 3
  • E3 Ubiquitin-Protein Ligase HECW2 3
  • EC 6.3.2.- 4
  • KIAA1301 4
  • EC 6.3.2 63

External Ids for HECW2 Gene

Previous GeneCards Identifiers for HECW2 Gene

  • GC02M196890
  • GC02M196772
  • GC02M197064
  • GC02M188916

Summaries for HECW2 Gene

GeneCards Summary for HECW2 Gene

HECW2 (HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and SMAD Signaling Network. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is AREL1.

UniProtKB/Swiss-Prot for HECW2 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECW2 Gene

Genomics for HECW2 Gene

Regulatory Elements for HECW2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HECW2 Gene

Start:
196,194,370 bp from pter
End:
196,593,692 bp from pter
Size:
399,323 bases
Orientation:
Minus strand

Genomic View for HECW2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HECW2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HECW2 Gene

Proteins for HECW2 Gene

  • Protein details for HECW2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2P5-HECW2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase HECW2
    Protein Accession:
    Q9P2P5
    Secondary Accessions:
    • B8ZZB4
    • Q17RT5
    • Q68DF8
    • Q9NPS9

    Protein attributes for HECW2 Gene

    Size:
    1572 amino acids
    Molecular mass:
    175769 Da
    Quaternary structure:
    • Interacts with TP73.
    SequenceCaution:
    • Sequence=BAA92539.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HECW2 Gene

    Alternative splice isoforms for HECW2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HECW2 Gene

Proteomics data for HECW2 Gene at MOPED

Selected DME Specific Peptides for HECW2 Gene

Post-translational modifications for HECW2 Gene

  • Ubiquitination at Lys183
  • Modification sites at PhosphoSitePlus

Other Protein References for HECW2 Gene

Domains for HECW2 Gene

Protein Domains for HECW2 Gene

Suggested Antigen Peptide Sequences for HECW2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2P5

UniProtKB/Swiss-Prot:

HECW2_HUMAN :
  • Q9P2P5
Domain:
  • Contains 1 C2 domain.
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Contains 2 WW domains.
genes like me logo Genes that share domains with HECW2: view

No data available for Gene Families for HECW2 Gene

Function for HECW2 Gene

Molecular function for HECW2 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.

Enzyme Numbers (IUBMB) for HECW2 Gene

Gene Ontology (GO) - Molecular Function for HECW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with HECW2: view

Phenotypes for HECW2 Gene

GenomeRNAi human phenotypes for HECW2:
genes like me logo Genes that share phenotypes with HECW2: view

Animal Model Products

CRISPR Products

miRNA for HECW2 Gene

miRTarBase miRNAs that target HECW2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HECW2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for HECW2 Gene

Localization for HECW2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HECW2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HECW2 Gene COMPARTMENTS Subcellular localization image for HECW2 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HECW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with HECW2: view

Pathways for HECW2 Gene

genes like me logo Genes that share pathways with HECW2: view

Pathways by source for HECW2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
    • Ubiquitination (Ubiquitylation) Pathway in human,mouse,rat

UniProtKB/Swiss-Prot Q9P2P5-HECW2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for HECW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with HECW2: view

Transcripts for HECW2 Gene

Unigene Clusters for HECW2 Gene

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HECW2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HECW2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HECW2 Gene

No ASD Table

Relevant External Links for HECW2 Gene

GeneLoc Exon Structure for
HECW2
ECgene alternative splicing isoforms for
HECW2

Expression for HECW2 Gene

mRNA expression in normal human tissues for HECW2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HECW2 Gene

This gene is overexpressed in Lung (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HECW2 Gene

SOURCE GeneReport for Unigene cluster for HECW2 Gene Hs.654742

mRNA Expression by UniProt/SwissProt for HECW2 Gene

Q9P2P5-HECW2_HUMAN
Tissue specificity: Predominantly expressed in adult brain, lung and heart.
genes like me logo Genes that share expressions with HECW2: view

In Situ Assay Products

Orthologs for HECW2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HECW2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HECW2 35
  • 99.45 (n)
  • 99.55 (a)
HECW2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HECW2 35
  • 93.97 (n)
  • 99.34 (a)
HECW2 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HECW2 35
  • 88.11 (n)
  • 92.59 (a)
HECW2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hecw2 35
  • 89.41 (n)
  • 95.23 (a)
Hecw2 16
Hecw2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HECW2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HECW2 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hecw2 35
  • 88.87 (n)
  • 94.66 (a)
chicken
(Gallus gallus)
Aves HECW2 35
  • 78.82 (n)
  • 87.12 (a)
HECW2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HECW2 36
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hecw2 35
  • 70.61 (n)
  • 78.57 (a)
HECW2 (2 of 2) 36
  • 67 (a)
OneToMany
hecw2a 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42797 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hecw-1 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1682 36
  • 68 (a)
OneToMany
Species with no ortholog for HECW2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HECW2 Gene

ENSEMBL:
Gene Tree for HECW2 (if available)
TreeFam:
Gene Tree for HECW2 (if available)

Paralogs for HECW2 Gene

Paralogs for HECW2 Gene

Selected SIMAP similar genes for HECW2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HECW2: view

Variants for HECW2 Gene

Sequence variations from dbSNP and Humsavar for HECW2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10782 -- 196,199,420(-) GGCAC(A/G)TACTG utr-variant-3-prime
rs724276 -- 196,318,294(+) ATTAA(A/G)TCCCA intron-variant
rs724277 -- 196,317,964(+) ACTTA(A/G)TTGAC intron-variant
rs729145 -- 196,232,928(-) AGAGG(G/T)GACTC intron-variant
rs745031 -- 196,233,059(-) TACCC(C/T)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HECW2 Gene

Variant ID Type Subtype PubMed ID
nsv875693 CNV Loss 21882294
nsv3095 CNV Insertion 18451855
esv2721335 CNV Deletion 23290073
nsv507058 CNV Insertion 20534489
nsv834504 CNV Loss 17160897
esv2671294 CNV Deletion 23128226
esv269040 CNV Insertion 20981092

Relevant External Links for HECW2 Gene

HapMap Linkage Disequilibrium report
HECW2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HECW2 Gene

Disorders for HECW2 Gene

Relevant External Links for HECW2

Genetic Association Database (GAD)
HECW2
Human Genome Epidemiology (HuGE) Navigator
HECW2
genes like me logo Genes that share disorders with HECW2: view

No data available for UniProtKB/Swiss-Prot for HECW2 Gene

Publications for HECW2 Gene

  1. A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity. (PMID: 12890487) Miyazaki K. … Nakagawara A. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for HECW2 Gene

  • Addgene plasmids for HECW2

Sources for HECW2 Gene

Back to Top

Content