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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HECW1 Gene

protein-coding   GIFtS: 50
GCID: GC07P043152

HECT, C2 and WW domain containing E3 ubiquitin protein ligase...
 Explore 7 diseases affiliated with
HECW1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HECW1    

Aliases
for HECW1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 11 2     HECT Type E3 Ubiquitin Ligase2
NEDL11 2 3     NEDD4-Like Ubiquitin-Protein Ligase 12
KIAA03221 3     EC 6.3.2.-3
HECT, C2 And WW Domain-Containing Protein 12 3     HNEDL11
NEDD4-Like E3 Ubiquitin-Protein Ligase 12 3     EC 6.3.28
E3 Ubiquitin-Protein Ligase HECW12     

External Ids:    HGNC: 221951   Entrez Gene: 230722   Ensembl: ENSG000000027467   OMIM: 6103845   UniProtKB: Q76N893   

Export aliases for HECW1 gene to outside databases

Previous GC identifers: GC07P043125 GC07P043118


Summaries
for HECW1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: HECW1_HUMAN, Q76N89
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the
mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1,
SSR3 and mutant SOD1 that lead to motor neuron death in FALS




Genomic Views
for HECW1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HECW1 gene promoter:
         USF1   AML1a   RREB-1   CUTL1   Egr-4   HEN1   E2F   USF-1   Pax-4a   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): HECW1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HECW1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HECW1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p13

HECW1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HECW1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P043152:  view genomic region     (about GC identifiers)

Start:
 43,152,198 bp from pter      End:
 43,602,938 bp from pter
Size:
 450,741 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 43,191,688-43,642,449     

Proteins
for HECW1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HECW1_HUMAN, Q76N89 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase HECW1  
Size: 1606 amino acids; 179554 Da
Subunit: Interacts with DVL1 and SSR3. Also interacts with mutant SOD1
Subcellular location: Cytoplasm
Sequence caution: Sequence=BAA20780.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for HECW1:
3L4H (3D)    
Secondary accessions: A7E2X0 A8MYS3 O15036 Q9HCC7

Explore the universe of human proteins at neXtProt for HECW1: NX_Q76N89

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q76N89

    • 4/7 DME Specific Peptides for HECW1 (Q76N89) (see all 7)
     KNKKEYI  NPYYGLF  RLLQFVTG  SCYSSSCY 

    HECW1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055867.3  
    ENSEMBL proteins: 
     ENSP00000379228   ENSP00000407774   ENSP00000413336  

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    Uscn Proteins for HECW1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    HECW1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HECW1

    Protein Domains /
    Families
    for HECW1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HECW1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR018029 C2_membr_targeting
     IPR000569 HECT
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR001202 WW_Rsp5_WWP
     IPR000008 C2_Ca-dep

    Graphical View of Domain Structure for InterPro Entry Q76N89

    ProtoNet protein and cluster: Q76N89

    2 Blocks protein families:
    IPB000008 C2 domain
    IPB000569 HECT domain (Ubiquitin-protein ligase)


    UniProtKB/Swiss-Prot: HECW1_HUMAN, Q76N89
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 2 WW domains


    Function
    for HECW1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HECW1_HUMAN, Q76N89
    Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the
    mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1,
    SSR3 and mutant SOD1 that lead to motor neuron death in FALS

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HECW1
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate HECW1 (see all 20):
    hsa-miR-30c hsa-miR-448 hsa-miR-202 hsa-miR-25 hsa-miR-30d hsa-miR-1184 hsa-miR-30a hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: HECW1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for HECW1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IBA--
    GO:0016881acid-amino acid ligase activity ----


    HECW1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for HECW1:
     Synthetic lethal with cisplati  Upregulation of NF-kappaB path  Upregulation of Wnt/beta-caten 


    Pathways & Interactions
    for HECW1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: HECW1_HUMAN, Q76N89
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HECW1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/14 Interacting proteins for HECW1 (Q76N892, 3 ENSP000003792284) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2870362 I2D: score=3 STRING: ENSP00000344782
    USP7Q930092, 3, ENSP000003435354MINT-2870381 I2D: score=3 STRING: ENSP00000343535
    SCNN1AP370883, ENSP000002289164I2D: score=1 STRING: ENSP00000228916
    SCNN1BP511683, ENSP000003457514I2D: score=1 STRING: ENSP00000345751
    SOD1P004413, ENSP000002701424I2D: score=1 STRING: ENSP00000270142
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process ----
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA--


    HECW1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HECW1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HECW1
    Search CenterWatch for drugs/clinical trials and news about HECW1 

    Transcripts
    for HECW1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HECW1 gene: 
    NM_015052.3  

    Unigene Cluster for HECW1:

    HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
    Hs.164453  [show with all ESTs]
    Unigene Representative Sequence: BC151227
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395891(uc003tid.1 uc011kbi.1) ENST00000490954 ENST00000453890
    ENST00000492310 ENST00000471527 ENST00000493057 ENST00000464944 ENST00000481031
    ENST00000471043(uc003tie.1) ENST00000461842 ENST00000429529

    miRNA
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    hsa-miR-30c hsa-miR-448 hsa-miR-202 hsa-miR-25 hsa-miR-30d hsa-miR-1184 hsa-miR-30a hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: HECW1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HECW1 (see all 6)
    Browse OriGene siRNA
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HECW1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HECW1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HECW1

    Additional cDNA sequence: 

    AB002320.2 AB048365.1 AK022679.1 AK090799.1 AK294918.1 BC151227.1 

    7 DOTS entries:

    DT.209806  DT.100009432  DT.75118674  DT.207947  DT.40293888  DT.92419450  DT.99934225 

    1 AceView cDNA sequence:

    AL079731 

    GeneLoc Exon Structure


    Expression
    for HECW1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HECW1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HECW1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HECW1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HECW1

    SOURCE GeneReport for Unigene cluster: Hs.164453

    UniProtKB/Swiss-Prot: HECW1_HUMAN, Q76N89
    Tissue specificity: Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including HECW1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for HECW1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HECW1 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HECW11 HECT, C2 and WW domain containing E3 ubiquitin protein more 75.98(n)
    82.71(a)    		   420774  XM_418870.3  XP_418870.3 
    lizard
    (Anolis carolinensis)    		 Reptilia HECW16
    		 --
    		 77(a)
    		 1 ↔ 1
    		 6(50673535-50805059)
    zebrafish
    (Danio rerio)    		 Actinopterygii hecw11 HECT, C2 and WW domain containing E3 ubiquitin protein more 69.34(n)
    74.83(a)    		   563730  NM_001145764.1  NP_001139236.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG427976
    		 --
    		 39(a)
    		 1 → many
    		 X(9502979-9517276)
    worm
    (Caenorhabditis elegans)    		 Secernentea hecw-16
    		 --
    		 25(a)
    		 1 → many
    		 III(3377400-3384160)


    ENSEMBL Gene Tree for HECW1 (if available)
    TreeFam Gene Tree for HECW1 (if available) 

    Paralogs
    for HECW1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HECW1 gene
    NEDD4L2  HECW22  HACE12  WWP22  KIAA03172  SMURF22  SMURF12  ITCH2  
    NEDD42  WWP12  
    18/43 SIMAP similar genes for HECW1 using alignment to 3 protein entries:     HECW1_HUMAN (see all proteins) (see all similar genes):
    NEDL1    TMEM14B    DCTN5    C10orf137    AURA2    BTBD2
    RUFY1    UTY    LINC00596    ERBB2    FAM175A    NPLOC4
    SHANK2    SLC11A2    ZNF564    FAM3A    RNF217    PKN1

    HECW1 for paralogs           About GeneDecksing



    Genomic Variants
    for HECW1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3013 NCBI SNPs in HECW1 are shown (see all 3013)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs77871431,2
    		C,F,A,H,--43043615(+) CCGTTA/CTTCAT 1 -- int127Minor allele frequency- C:0.18NS EA NA WA CSA 2744
    rs593007631,2
    		C,--43153271(+) GGGAG-/CGGGGG 1 -- int10--------
    rs1509410341,2
    		--43155730(+) GAACCA/GAGAGC 1 -- us2k10--------
    rs1839041711,2
    		--43155761(+) TCCACC/TACCCA 1 -- us2k10--------
    rs1421981161,2
    		C,--43155775(+) TAAAC-/AAAAAA 1 -- us2k10--------
    rs1876687611,2
    		--43155911(+) CCTTAA/GAAGGA 1 -- us2k10--------
    rs1407610041,2
    		--43155965(+) AAGACA/GTGAGC 1 -- us2k10--------
    rs1898116941,2
    		--43156116(+) GTTAGA/CCCAGA 1 -- us2k10--------
    rs1501204311,2
    		--43156235(+) TTACCC/TGCTTC 1 -- us2k10--------
    rs1824200221,2
    		--43156248(+) TTTCCA/GTCCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HECW1 (43152198 - 43402198 bp, first 250kb of HECW1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for HECW1
         5 CNVs: 52229 99935 81921 94460 52228
         4 Indels: 40974 47357 94461 42068

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for HECW1

    Disorders / Diseases
    for HECW1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HECW1 for disorders           About GeneDecksing

    OMIM gene information: 610384    OMIM disorders: --

    7 diseases for HECW1:    About MalaCards
    amyotrophic lateral sclerosis    lateral sclerosis    liddle syndrome    macular degeneration
    ataxia    malaria    neuronitis


    Export disorders for HECW1 gene to outside databases

    Publications
    for HECW1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HECW1 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with HECW1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1. (PubMed id 14684739)1, 2, 3, 9 Miyazaki K....Nakagawara A. (2004)
    2. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 3 Scherer S.W.... Tsui L.-C. (2003)
    3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    4. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)
    5. A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner. (PubMed id 18223681)1, 9 Li Y....Nakagawara A. (2008)
    6. Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice. (PubMed id 20976258)1 Zhang L....Nakagawara A. (2011)
    7. Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. RNF43 interacts with NEDL1 and regulates p53-mediated transcription. (PubMed id 21108931)1 Shinada K....Hatakeyama S. (2011)

    External Searches for HECW1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing HECW1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23072 HGNC: 22195 AceView: NEDL1.1 Ensembl:ENSG00000002746 euGenes: HUgn23072
    ECgene: HECW1 H-InvDB: HECW1

    Other Databases showing HECW1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0322

    Specialized Databases showing HECW1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HECW1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HECW1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HECW1 gene:
    Search GeneIP for patents involving HECW1

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