Aliases for HECW1 Gene
External Ids for HECW1 Gene
Previous GeneCards Identifiers for HECW1 Gene
GeneCards Summary for HECW1 Gene
HECW1 (HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Among its related pathways are SMAD Signaling Network and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is HECW2.
UniProtKB/Swiss-Prot for HECW1 Gene
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.