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Aliases for HECTD4 Gene

Aliases for HECTD4 Gene

  • HECT Domain E3 Ubiquitin Protein Ligase 4 2 3
  • HECT Domain Containing E3 Ubiquitin Protein Ligase 4 2 3 5
  • HECT Domain-Containing Protein 4 3 4
  • C12orf51 3 4
  • Probable E3 Ubiquitin-Protein Ligase C12orf51 3
  • Chromosome 12 Open Reading Frame 51 2
  • AF-1 Specific Protein Phosphatase 3
  • Transmembrane Protein C12orf51 3
  • EC 6.3.2.- 4
  • KIAA0614 4
  • POTAGE 3

External Ids for HECTD4 Gene

Previous HGNC Symbols for HECTD4 Gene

  • C12orf51

Previous GeneCards Identifiers for HECTD4 Gene

  • GC12M112597

Summaries for HECTD4 Gene

GeneCards Summary for HECTD4 Gene

HECTD4 (HECT Domain E3 Ubiquitin Protein Ligase 4) is a Protein Coding gene. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for HECTD4 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECTD4 Gene

Genomics for HECTD4 Gene

Regulatory Elements for HECTD4 Gene

Promoters for HECTD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HECTD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for HECTD4 Gene

Chromosome:
12
Start:
112,160,188 bp from pter
End:
112,382,439 bp from pter
Size:
222,252 bases
Orientation:
Minus strand

Genomic View for HECTD4 Gene

Genes around HECTD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HECTD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HECTD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HECTD4 Gene

Proteins for HECTD4 Gene

  • Protein details for HECTD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4D8-HECD4_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase HECTD4
    Protein Accession:
    Q9Y4D8
    Secondary Accessions:
    • L8B0P6
    • Q3MJD5
    • Q6P0A0
    • Q7L530
    • Q8NB70
    • Q8WU73
    • Q96NT9
    • Q9NZS4
    • Q9UFT6

    Protein attributes for HECTD4 Gene

    Size:
    3996 amino acids
    Molecular mass:
    439344 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF36539.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAH65706.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH65706.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI01483.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA31589.3; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAC03671.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for HECTD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HECTD4 Gene

Proteomics data for HECTD4 Gene at MOPED

Post-translational modifications for HECTD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HECTD4 Gene

No data available for DME Specific Peptides for HECTD4 Gene

Domains & Families for HECTD4 Gene

Protein Domains for HECTD4 Gene

Suggested Antigen Peptide Sequences for HECTD4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y4D8

UniProtKB/Swiss-Prot:

HECD4_HUMAN :
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Domain:
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
genes like me logo Genes that share domains with HECTD4: view

No data available for Gene Families for HECTD4 Gene

Function for HECTD4 Gene

Molecular function for HECTD4 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for HECTD4 Gene

Gene Ontology (GO) - Molecular Function for HECTD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with HECTD4: view
genes like me logo Genes that share phenotypes with HECTD4: view

Animal Model Products

miRNA for HECTD4 Gene

miRTarBase miRNAs that target HECTD4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HECTD4 Gene

Localization for HECTD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HECTD4 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HECTD4 Gene COMPARTMENTS Subcellular localization image for HECTD4 gene
Compartment Confidence
cytosol 3
plasma membrane 3
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for HECTD4 Gene

Pathways & Interactions for HECTD4 Gene

SuperPathways for HECTD4 Gene

No Data Available

UniProtKB/Swiss-Prot Q9Y4D8-HECD4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for HECTD4 Gene

Gene Ontology (GO) - Biological Process for HECTD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process IMP 23575436
GO:0016567 protein ubiquitination IEA --
GO:0042593 glucose homeostasis IMP 23575436
genes like me logo Genes that share ontologies with HECTD4: view

No data available for Pathways by source and SIGNOR curated interactions for HECTD4 Gene

Drugs & Compounds for HECTD4 Gene

No Compound Related Data Available

Transcripts for HECTD4 Gene

Unigene Clusters for HECTD4 Gene

HECT domain containing E3 ubiquitin protein ligase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HECTD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1:
SP2:

Relevant External Links for HECTD4 Gene

GeneLoc Exon Structure for
HECTD4
ECgene alternative splicing isoforms for
HECTD4

Expression for HECTD4 Gene

mRNA expression in normal human tissues for HECTD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HECTD4 Gene

This gene is overexpressed in Adrenal (10.2), Plasma (9.0), Fetal Brain (6.9), Skin (6.3), and Liver, secretome (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HECTD4 Gene



SOURCE GeneReport for Unigene cluster for HECTD4 Gene Hs.530943

genes like me logo Genes that share expression patterns with HECTD4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HECTD4 Gene

Orthologs for HECTD4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HECTD4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HECTD4 35
  • 92.28 (n)
  • 98.37 (a)
-- 36
  • 97 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HECTD4 35
  • 91.99 (n)
  • 98.15 (a)
HECTD4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm15800 35
  • 88.55 (n)
  • 97.12 (a)
Gm15800 16
Gm15800 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HECTD4 35
  • 99.71 (n)
  • 99.88 (a)
HECTD4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1309762 35
  • 88.36 (n)
  • 97.03 (a)
oppossum
(Monodelphis domestica)
Mammalia HECTD4 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HECTD4 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves C15H12orf51 35
  • 80.86 (n)
  • 93.11 (a)
HECTD4 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HECTD4 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hectd4 35
  • 76.25 (n)
  • 88.26 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101885095 35
  • 71.68 (n)
  • 81.51 (a)
CU459012.3 36
  • 84 (a)
OneToMany
HECTD4 (1 of 3) 36
  • 77 (a)
OneToMany
HECTD4 (3 of 3) 36
  • 76 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToOne
Species with no ortholog for HECTD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HECTD4 Gene

ENSEMBL:
Gene Tree for HECTD4 (if available)
TreeFam:
Gene Tree for HECTD4 (if available)

Paralogs for HECTD4 Gene

(1) SIMAP similar genes for HECTD4 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for HECTD4 Gene

genes like me logo Genes that share paralogs with HECTD4: view

No data available for Paralogs for HECTD4 Gene

Variants for HECTD4 Gene

Sequence variations from dbSNP and Humsavar for HECTD4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs3519 -- 112,160,517(+) AATGT(A/G)CTCTC utr-variant-3-prime
rs12462 -- 112,161,652(-) AGTTC(A/G)CAGAG utr-variant-3-prime
rs744582 -- 112,234,777(+) ACTGG(A/G)GGCTT intron-variant
rs757163 -- 112,235,981(-) TCTTT(A/C)TTTTT intron-variant
rs1234524 -- 112,181,904(-) atgtt(G/T)gccag intron-variant

Variation tolerance for HECTD4 Gene

Gene Damage Index Score: 3.58; 56.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HECTD4 Gene

HapMap Linkage Disequilibrium report
HECTD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HECTD4 Gene

Disorders for HECTD4 Gene

Relevant External Links for HECTD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HECTD4

No disorders were found for HECTD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HECTD4 Gene

Publications for HECTD4 Gene

  1. Identification of a novel gene by whole human genome tiling array. (PMID: 23261826) Ishida H. … Tashiro K. (Gene 2013) 3 4 67
  2. Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. (PMID: 21270382) Baik I. … Shin C. (Am. J. Clin. Nutr. 2011) 2 3
  3. Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. (PMID: 25249183) Lu X. … Gu D. (Hum. Mol. Genet. 2015) 3
  4. Common variants at 12q24 are associated with drinking behavior in Han Chinese. (PMID: 23364009) Yang X. … Gu D. (Am. J. Clin. Nutr. 2013) 3
  5. New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population. (PMID: 23575436) Go M.J. … Lee J.Y. (J. Hum. Genet. 2013) 3

Products for HECTD4 Gene

Sources for HECTD4 Gene

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