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HECTD4 Gene

protein-coding   GIFtS: 38
GCID: GC12M112597

HECT Domain Containing E3 Ubiquitin Protein Ligase 4

(Previous name: chromosome 12 open reading frame 51)
(Previous symbol: C12orf51)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HECT Domain Containing E3 Ubiquitin Protein Ligase 41 2     Probable E3 Ubiquitin-Protein Ligase C12orf512
C12orf511 2 3     Probable E3 Ubiquitin-Protein Ligase HECTD42
HECT Domain-Containing Protein 42 3     Transmembrane Protein C12orf512
Chromosome 12 Open Reading Frame 511     EC 6.3.2.-3
POTAGE2     KIAA06143
AF-1 Specific Protein Phosphatase2     

External Ids:    HGNC: 266111   Entrez Gene: 2834502   Ensembl: ENSG000001730647   UniProtKB: Q9Y4D83   

Export aliases for HECTD4 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HECTD4 Gene:
HECTD4 (HECT domain containing E3 ubiquitin protein ligase 4) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is HERC1.

UniProtKB/Swiss-Prot: HECD4_HUMAN, Q9Y4D8
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for HECTD4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HECTD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HECTD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.13   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.13

HECTD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HECTD4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M112597:  view genomic region     (about GC identifiers)

Start:
112,597,992 bp from pter      End:
112,819,896 bp from pter
Size:
221,905 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HECD4_HUMAN, Q9Y4D8 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase HECTD4  
Size: 3996 amino acids; 439344 Da
Sequence caution: Sequence=AAF36539.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part; Sequence=AAH65706.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=AAH65706.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.
Potential poly-A sequence; Sequence=AAI01483.1; Type=Erroneous initiation; Note=Translation N-terminally
extended; Sequence=BAA31589.3; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown
origin in the N-terminal part; Sequence=BAC03671.1; Type=Erroneous initiation; Note=Translation N-terminally
extended;
Secondary accessions: L8B0P6 Q3MJD5 Q6P0A0 Q7L530 Q8NB70 Q8WU73 Q96NT9 Q9NZS4 Q9UFT6
Alternative splicing: 5 isoforms:  Q9Y4D8-1   Q9Y4D8-2   Q9Y4D8-3   Q9Y4D8-4   Q9Y4D8-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HECTD4: NX_Q9Y4D8

Explore proteomics data for HECTD4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HECTD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001103132.3  
    ENSEMBL proteins: 
     ENSP00000449784   ENSP00000477079   ENSP00000448061   ENSP00000366783   ENSP00000404379  

    HECTD4 Human Recombinant Protein Products:

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    Novus Biologicals HECTD4 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HECTD4 

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    HECTD4 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HECTD4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000569 HECT

    Graphical View of Domain Structure for InterPro Entry Q9Y4D8

    ProtoNet protein and cluster: Q9Y4D8

    1 Blocks protein domain: IPB000569 HECT domain (Ubiquitin-protein ligase)

    UniProtKB/Swiss-Prot: HECD4_HUMAN, Q9Y4D8
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain


    Find genes that share domains with HECTD4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HECD4_HUMAN, Q9Y4D8
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
    of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IBA--
         
    Find genes that share ontologies with HECTD4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for HECTD4:
     Increased G1 DNA content  Increased cell size 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HECTD4
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HECTD4

    miRNA
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    miRTarBase miRNAs that target HECTD4:
    hsa-mir-335-5p (MIRT016980), hsa-mir-296-3p (MIRT038449), hsa-mir-149-5p (MIRT045628)

    Block miRNA regulation of human, mouse, rat HECTD4 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HECD4_HUMAN, Q9Y4D8: Membrane; Single-pass membrane protein (Potential)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IBA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with HECTD4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: HECD4_HUMAN, Q9Y4D8
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HECTD4
    Interactions:

        Search GeneGlobe Interaction Network for HECTD4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for HECTD4 (Q9Y4D83 ENSP000003667834) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631043, ENSP000003095034I2D: score=1 STRING: ENSP00000309503
    ELP3ENSP000002563984STRING: ENSP00000256398
    RANGAP1ENSP000003485774STRING: ENSP00000348577
    NAP1L5ENSP000003204884STRING: ENSP00000320488
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006006glucose metabolic process IMP--
    GO:0042593glucose homeostasis IMP--
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA--

    Find genes that share ontologies with HECTD4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HECTD4 (HECD4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HECTD4 gene (2 alternative transcripts): 
    NM_173813.2  NM_001109662.3  

    Unigene Cluster for HECTD4:

    HECT domain containing E3 ubiquitin protein ligase 4
    Hs.530943  [show with all ESTs]
    Unigene Representative Sequence: NM_001109662
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000550722(uc021reb.1) ENST00000549306 ENST00000549141 ENST00000547085
    ENST00000548140 ENST00000548588 ENST00000548896 ENST00000550968(uc001ttr.1)
    ENST00000552437 ENST00000547519 ENST00000311694(uc010syk.1 uc001tts.2 uc001ttt.3)
    ENST00000547352 ENST00000550724 ENST00000377560 ENST00000430131
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HECTD4
    Clone
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat HECTD4
      QuantiFast Probe-based Assays in human, mouse, rat HECTD4

    Additional mRNA sequence: 

    AB014514.3 AB777655.1 AF174498.1 AK001372.1 AK054654.1 AK054770.1 AL117469.1 BC006270.2 
    BC021144.1 BC065706.1 

    23 DOTS entries:

    DT.442652  DT.75193270  DT.91768414  DT.75106915  DT.100783070  DT.92032612  DT.434827  DT.105510 
    DT.100014358  DT.75120022  DT.40211847  DT.40300071  DT.91727912  DT.92041942  DT.100008641  DT.101960622 
    DT.121187028  DT.121187050  DT.91746621  DT.91995557  DT.95353912  DT.99991114  DT.40255350 

    Selected AceView cDNA sequences (see all 61):

    NM_173813 BX095479 CA394513 AX747007 AK091473 BE675498 AF086006 AI432166 
    AI242324 BF434969 AA287620 AI760030 H64722 AW663726 H65212 AA007484 
    BC065706 BI027348 AI807657 AA424910 AA424778 AA203448 R11131 AA007416 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for HECTD4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
    SP1:                                                                                                      
    SP2:                                                                                                      


    ECgene alternative splicing isoforms for HECTD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HECTD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HECTD4 Expression
    About this image

    HECTD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HECTD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530943
        Custom PCR Arrays for HECTD4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HECTD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HECTD4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm158001 predicted gene 15800 88.55(n)
    97.12(a)
      269700  NM_181421.4  NP_852086.3 
    chicken
    (Gallus gallus)
    Aves C15H12orf511 chromosome 15 open reading frame, human C12orf51 80.86(n)
    93.11(a)
      426582  XM_415176.4  XP_415176.4 
    lizard
    (Anolis carolinensis)
    Reptilia HECTD46
    HECT domain containing E3 ubiquitin protein ligase...
    90(a)
    1 ↔ 1
    GL343282.1(182112-259546)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hectd41 HECT domain containing E3 ubiquitin protein ligase more 76.25(n)
    88.26(a)
      100145058  XM_004910504.1  XP_004910561.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018850951 probable E3 ubiquitin-protein ligase HECTD4-like 71.68(n)
    81.51(a)
      101885095  XM_005169056.1  XP_005169113.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOM16
    E3 ubiquitin ligase of the hect-domain class; has ...
    19(a)
    1 → many
    IV(1369790-1379596) YDR457W


    ENSEMBL Gene Tree for HECTD4 (if available)
    TreeFam Gene Tree for HECTD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HECTD4 gene
    HERC12  HACE12  HECTD32  HERC22  
    1 SIMAP similar gene for HECTD4 using alignment to 5 protein entries:     HECD4_HUMAN (see all proteins):
    C12orf51

    Find genes that share paralogs with HECTD4           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for HECTD4
    PGOHUM00000259169 PGOHUM00000234297


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HECTD4 (see all 3618)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451649741,2
    Cuntested1112631399(+) AGGTCC/TGTGGC 2 T syn10--------
    rs1826179201,2
    --112597709(+) GGTAGG/TTCTAC 1 -- ds50010--------
    rs1178216491,2
    C,F--112597784(+) AATCCG/ACTTGA 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1122368281,2
    F--112597847(+) GTGGGG/CAGGGG 1 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs1902032651,2
    --112597860(+) GTAGGA/GTTAGG 1 -- ds50010--------
    rs1458040341,2
    --112597896(+) GCCTTC/TGTAAT 1 -- ds50010--------
    rs1827963041,2
    --112597977(+) AATCAC/TGTCAA 1 -- ds50010--------
    rs1383768961,2
    --112598010(+) AGAAAC/TACTTT 1 -- ut310--------
    rs124260921,2
    H--112598231(+) ATGCAA/CCCata 1 -- ut314Minor allele frequency- C:0.00NS EA 412
    rs1493360821,2
    --112598258(+) ATACAC/TCAAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HECTD4 (112597992 - 112819896 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HECTD4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HECTD4
    DNA2.0 Custom Variant and Variant Library Synthesis for HECTD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HECTD4 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with HECTD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel gene by whole human genome tiling array. (PubMed id 23261826)1, 2 Ishida H.... Tashiro K. (Gene 2013)
    2. Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. (PubMed id 21270382)1, 3 Baik I....Shin C. (Am. J. Clin. Nutr. 2011)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1998)
    5. New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population. (PubMed id 23575436)1 Go M.J....Lee J.Y. (J. Hum. Genet. 2013)
    6. Common variants at 12q24 are associated with drinking behavior in Han Chinese. (PubMed id 23364009)1 Yang X....Gu D. (Am. J. Clin. Nutr. 2013)
    7. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (Nat. Genet. 2012)
    8. Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. (PubMed id 22751097)1 Lu X....Gu D. (Nat. Genet. 2012)
    9. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. (PubMed id 21909109)1 Kim Y.J....Cho Y.S. (Nat. Genet. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283450 HGNC: 26611 AceView: FLJ34154 Ensembl:ENSG00000173064 euGenes: HUgn283450
    ECgene: HECTD4 H-InvDB: HECTD4

    (According to HUGE)
    About This Section

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    HUGE: KIAA0614

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HECTD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HECTD4 gene:
    Search GeneIP for patents involving HECTD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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