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Aliases for HECTD3 Gene

Aliases for HECTD3 Gene

  • HECT Domain Containing E3 Ubiquitin Protein Ligase 3 2 3
  • HECT Domain-Containing Protein 3 4
  • HECT Domain Containing 3 2
  • EC 6.3.2.- 4

External Ids for HECTD3 Gene

Previous GeneCards Identifiers for HECTD3 Gene

  • GC01M045138
  • GC01M045240
  • GC01M045468
  • GC01M043580

Summaries for HECTD3 Gene

Entrez Gene Summary for HECTD3 Gene

  • The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]

GeneCards Summary for HECTD3 Gene

HECTD3 (HECT Domain Containing E3 Ubiquitin Protein Ligase 3) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity and syntaxin binding. An important paralog of this gene is HACE1.

UniProtKB/Swiss-Prot for HECTD3 Gene

  • E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECTD3 Gene

Genomics for HECTD3 Gene

Regulatory Elements for HECTD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HECTD3 Gene

Start:
45,002,540 bp from pter
End:
45,011,355 bp from pter
Size:
8,816 bases
Orientation:
Minus strand

Genomic View for HECTD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HECTD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HECTD3 Gene

Proteins for HECTD3 Gene

  • Protein details for HECTD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T447-HECD3_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase HECTD3
    Protein Accession:
    Q5T447
    Secondary Accessions:
    • B3KPV7
    • B3KRH4
    • Q5T448
    • Q9H783

    Protein attributes for HECTD3 Gene

    Size:
    861 amino acids
    Molecular mass:
    97113 Da
    Quaternary structure:
    • Interacts with TRIOBP. Interacts with STX8 (By similarity).
    SequenceCaution:
    • Sequence=BAB15015.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for HECTD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HECTD3 Gene

Proteomics data for HECTD3 Gene at MOPED

Post-translational modifications for HECTD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HECTD3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HECTD3 Gene

Domains for HECTD3 Gene

Protein Domains for HECTD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T447

UniProtKB/Swiss-Prot:

HECD3_HUMAN :
  • Q5T447
Domain:
  • Contains 1 DOC domain.
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
genes like me logo Genes that share domains with HECTD3: view

No data available for Gene Families for HECTD3 Gene

Function for HECTD3 Gene

Molecular function for HECTD3 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).

Enzyme Numbers (IUBMB) for HECTD3 Gene

Gene Ontology (GO) - Molecular Function for HECTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding IPI 18194665
GO:0016874 ligase activity IEA --
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with HECTD3: view

Phenotypes for HECTD3 Gene

genes like me logo Genes that share phenotypes with HECTD3: view

Animal Model Products

miRNA for HECTD3 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for HECTD3 Gene

Localization for HECTD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HECTD3 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HECTD3 Gene COMPARTMENTS Subcellular localization image for HECTD3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for HECTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with HECTD3: view

Pathways for HECTD3 Gene

genes like me logo Genes that share pathways with HECTD3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q5T447-HECD3_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for HECTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA 18194665
genes like me logo Genes that share ontologies with HECTD3: view

Transcripts for HECTD3 Gene

Unigene Clusters for HECTD3 Gene

HECT domain containing E3 ubiquitin protein ligase 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HECTD3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HECTD3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP6:
SP7: - -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 15b · 15c ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8: -
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for HECTD3 Gene

GeneLoc Exon Structure for
HECTD3
ECgene alternative splicing isoforms for
HECTD3

Expression for HECTD3 Gene

mRNA expression in normal human tissues for HECTD3 Gene

Protein differential expression in normal tissues for HECTD3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0) and Lymph node (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HECTD3 Gene

SOURCE GeneReport for Unigene cluster for HECTD3 Gene Hs.525084

genes like me logo Genes that share expressions with HECTD3: view

Expression partners for HECTD3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HECTD3 Gene

Orthologs for HECTD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HECTD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HECTD3 35
  • 92.68 (n)
  • 98.49 (a)
HECTD3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HECTD3 35
  • 92.14 (n)
  • 98.37 (a)
HECTD3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hectd3 35
  • 90.59 (n)
  • 97.79 (a)
Hectd3 16
Hectd3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HECTD3 35
  • 99.54 (n)
  • 99.77 (a)
HECTD3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hectd3 35
  • 88.02 (n)
  • 93.92 (a)
oppossum
(Monodelphis domestica)
Mammalia HECTD3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 1 (a)
OneToMany
-- 36
  • 1 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 3 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves HECTD3 35
  • 76.17 (n)
  • 81.74 (a)
-- 36
  • 68 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HECTD3 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hectd3 35
  • 66.95 (n)
  • 70.53 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16865 35
zebrafish
(Danio rerio)
Actinopterygii Dr.4430 35
hectd3 35
  • 67.1 (n)
  • 70.17 (a)
hectd3 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HERC2 36
  • 4 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8388 36
  • 5 (a)
ManyToMany
Species with no ortholog for HECTD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HECTD3 Gene

ENSEMBL:
Gene Tree for HECTD3 (if available)
TreeFam:
Gene Tree for HECTD3 (if available)

Paralogs for HECTD3 Gene

Paralogs for HECTD3 Gene

genes like me logo Genes that share paralogs with HECTD3: view

Variants for HECTD3 Gene

Sequence variations from dbSNP and Humsavar for HECTD3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs5869 -- 45,002,936(-) CCCTC(C/T)ACACC utr-variant-3-prime
rs8681 -- 45,002,934(-) CTCCA(C/T)ACCAG utr-variant-3-prime
rs2275598 -- 45,009,083(-) ACAGA(C/G)AGTGT intron-variant
rs2275599 -- 45,009,078(-) GAGTG(A/T)GTGTG intron-variant
rs2298006 -- 45,008,485(-) TGAGC(C/T)TTGTG intron-variant

Relevant External Links for HECTD3 Gene

HapMap Linkage Disequilibrium report
HECTD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HECTD3 Gene

Disorders for HECTD3 Gene

No disorders were found for HECTD3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HECTD3 Gene

Publications for HECTD3 Gene

  1. The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. (PMID: 18194665) Yu J. … Huang H. (Biochem. Biophys. Res. Commun. 2008) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for HECTD3 Gene

Sources for HECTD3 Gene

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