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HECTD3 Gene

protein-coding   GIFtS: 46
GCID: GC01M045468

HECT Domain Containing E3 Ubiquitin Protein Ligase 3

(Previous name: HECT domain containing 3)
  Search for HECTD3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HECT Domain Containing E3 Ubiquitin Protein Ligase 31 2
HECT Domain Containing 31
E3 Ubiquitin-Protein Ligase HECTD32
EC 6.3.2.-3
HECT Domain-Containing Protein 33

External Ids:    HGNC: 261171   Entrez Gene: 796542   Ensembl: ENSG000001261077   UniProtKB: Q5T4473   

Export aliases for HECTD3 gene to outside databases

Previous GC identifers: GC01M045138 GC01M045240 GC01M043580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HECTD3 Gene:
The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted
substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer
ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. (provided by RefSeq, Dec 2012)

GeneCards Summary for HECTD3 Gene:
HECTD3 (HECT domain containing E3 ubiquitin protein ligase 3) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and syntaxin binding. An important paralog of this gene is HERC1.

UniProtKB/Swiss-Prot: HECD3_HUMAN, Q5T447
Function: E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a
thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and
its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of
TRIOBP. Mediates also ubiquitination of STX8 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the HECTD3 gene promoter:
         AhR   USF1   Pbx1a   Brachyury   Nkx2-5   CUTL1   Tal-1beta   E47   Arnt   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHECTD3 promoter sequence
   Search Chromatin IP Primers for HECTD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HECTD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

HECTD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HECTD3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M045468:  view genomic region     (about GC identifiers)

Start:
45,468,212 bp from pter      End:
45,477,027 bp from pter
Size:
8,816 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HECD3_HUMAN, Q5T447 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase HECTD3  
Size: 861 amino acids; 97113 Da
Subunit: Interacts with TRIOBP. Interacts with STX8 (By similarity)
Sequence caution: Sequence=BAB15015.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part;
Secondary accessions: B3KPV7 B3KRH4 Q5T448 Q9H783
Alternative splicing: 2 isoforms:  Q5T447-1   Q5T447-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HECTD3: NX_Q5T447

Explore proteomics data for HECTD3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HECTD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078878.3  
    ENSEMBL proteins: 
     ENSP00000361241   ENSP00000361245  
    Reactome Protein details: Q5T447

    HECTD3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004939 APC_su10/DOC_dom
     IPR000569 HECT
     IPR008979 Galactose-bd-like

    Graphical View of Domain Structure for InterPro Entry Q5T447

    ProtoNet protein and cluster: Q5T447

    1 Blocks protein domain: IPB000569 HECT domain (Ubiquitin-protein ligase)

    UniProtKB/Swiss-Prot: HECD3_HUMAN, Q5T447
    Similarity: Contains 1 DOC domain
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain


    Find genes that share domains with HECTD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HECD3_HUMAN, Q5T447
    Function: E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a
    thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and
    its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of
    TRIOBP. Mediates also ubiquitination of STX8 (By similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ISS--
    GO:0005515protein binding IPI18194665
    GO:0019905syntaxin binding IEA--
         
    Find genes that share ontologies with HECTD3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for HECTD3:
     Increased Salmonella enterica   Synthetic lethal with paclitax 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HECTD3
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    miRNA
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    miRTarBase miRNAs that target HECTD3:
    hsa-mir-615-3p (MIRT039878), hsa-mir-7-5p (MIRT025780), hsa-mir-484 (MIRT041762), hsa-mir-26b-5p (MIRT029557), hsa-mir-122-5p (MIRT023327)

    Block miRNA regulation of human, mouse, rat HECTD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HECTD3 (see all 19):
    hsa-miR-562 hsa-miR-642a hsa-miR-185* hsa-miR-4272 hsa-miR-486-3p hsa-miR-218 hsa-miR-3190 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidHECTD3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HECTD3

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    GenScript: all cDNA clones in your preferred vector: HECTD3 (NM_024602)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HECTD3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HECTD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HECD3_HUMAN, Q5T447: Cytoplasm, perinuclear region (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IBA--
    GO:0048471perinuclear region of cytoplasm ISS--

    Find genes that share ontologies with HECTD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HECTD3 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with HECTD3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for HECTD3
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: HECD3_HUMAN, Q5T447
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including HECTD3: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HECTD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HECTD3 (Q5T4473 ENSP000003612454) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAVSQ7Z4343, ENSP000004019804I2D: score=1 STRING: ENSP00000401980
    STX8Q9UNK03, ENSP000003052554I2D: score=1 STRING: ENSP00000305255
    TRIOBPQ9H2D63, ENSP000003843124I2D: score=1 STRING: ENSP00000384312
    SMAD2Q157963I2D: score=1 
    LCE2BENSP000003577694STRING: ENSP00000357769
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA--
    GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process IDA18194665

    Find genes that share ontologies with HECTD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HECTD3 (HECD3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HECTD3 gene: 
    NM_024602.5  

    Unigene Cluster for HECTD3:

    HECT domain containing E3 ubiquitin protein ligase 3
    Hs.525084  [show with all ESTs]
    Unigene Representative Sequence: NM_024602
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486132(uc001cmx.4) ENST00000372168(uc001cmy.4) ENST00000372172(uc009vxk.3 uc010olh.2)
    ENST00000486296 ENST00000466423 ENST00000487488 ENST00000484564
    miRNA
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    Block miRNA regulation of human, mouse, rat HECTD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HECTD3 (see all 19):
    hsa-miR-562 hsa-miR-642a hsa-miR-185* hsa-miR-4272 hsa-miR-486-3p hsa-miR-218 hsa-miR-3190 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidHECTD3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: HECTD3 (NM_024602)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HECTD3
    Primer
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    OriGene qPCR primer pairs and template standards for HECTD3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HECTD3
      QuantiTect SYBR Green Assays in human, mouse, rat HECTD3
      QuantiFast Probe-based Assays in human, mouse, rat HECTD3

    Additional mRNA sequence: 

    AK056545.1 AK096462.1 AK301124.1 BC012829.2 BC019105.2 BC126352.1 BC130470.1 

    19 DOTS entries:

    DT.121425803  DT.80100930  DT.100772850  DT.95193091  DT.424396  DT.100037311  DT.100037312  DT.85105542 
    DT.432313  DT.121425857  DT.95193089  DT.100853950  DT.102829428  DT.102829429  DT.92461528  DT.95193080 
    DT.100033938  DT.449721  DT.95178643 

    Selected AceView cDNA sequences (see all 222):

    BM018729 AA633362 AW841065 AW005743 CR618738 CB118030 AA351229 CF125815 
    BM810427 BQ954836 NM_024602 CK430344 BU186898 R53611 CA397119 AA323280 
    BF869125 AI201686 BE179554 AW170440 AW005515 BQ061254 BM835610 BQ215795 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HECTD3 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a ·
    SP1:                                                                                      -                                   -                             -   
    SP2:                                                                                                                          -                             -   
    SP3:                                                                                      -                                                                     
    SP4:                                                                                                                          -                             -   
    SP5:        -                                                                                                                                                   

    ExUns: 15b · 15c ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                    -                                             
    SP2:                    -                                             
    SP3:                                                                  
    SP4:        -           -                                             
    SP5:                                                                  


    ECgene alternative splicing isoforms for HECTD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HECTD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAGAAGTT
    HECTD3 Expression
    About this image

    HECTD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HECTD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525084
        Pathway & Disease-focused RT2 Profiler PCR Array including HECTD3: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat HECTD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HECTD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HECTD3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hectd31 , 5 HECT domain containing 31, 5 90.59(n)1
    97.79(a)1
      4 (53.41 cM)5
    766081  NM_175244.31  NP_780453.11 
     1169953175 
    chicken
    (Gallus gallus)
    Aves HECTD31 HECT domain containing 3 76.17(n)
    81.74(a)
      424589  XM_422429.4  XP_422429.2 
    lizard
    (Anolis carolinensis)
    Reptilia HECTD36
    HECT domain containing E3 ubiquitin protein ligase...
    80(a)
    1 ↔ 1
    4(110618391-110642884)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.168652 Xenopus laevis transcribed sequence with moderate similarity more 76.27(n)    BI444582.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.44302 Transcribed sequence with moderate similarity to protein more 76.37(n)    57049404 
    fruit fly
    (Drosophila melanogaster)
    Insecta HERC26
    HERC2
    4(a)
    1 → many
    X(20265505-20283274)


    ENSEMBL Gene Tree for HECTD3 (if available)
    TreeFam Gene Tree for HECTD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HECTD3 gene
    HERC12  HECTD42  HACE12  HERC22  

    Find genes that share paralogs with HECTD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HECTD3 (see all 394)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1443291711,2
    C--45471980(+) TCTAT-/TTTTTT 1 -- int10--------
    rs1902205411,2
    --45545515(+) CCCAGA/GCTGGA 1 -- ds50010--------
    rs1149026131,2
    F--45545535(+) GACTGC/TACCAC 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1814697611,2
    --45545545(+) CTACAC/TGCCAG 1 -- ds50010--------
    rs1502879001,2
    C--45545546(+) TACACA/GCCAGC 1 -- ds50010--------
    rs1497702551,2
    --45545567(+) GAGACA/CCAAAC 1 -- ds50010--------
    rs3733747971,2
    C--45545568(+) GAGAC-/CAAA  
            
    AAACA
    1 -- ds50010--------
    rs1854956251,2
    --45545648(+) TCCTCC/TACTTC 1 -- ds50010--------
    rs1494713241,2
    --45545791(+) CCAGGC/GCAGCC 1 -- ds50010--------
    rs1142245331,2
    F--45545860(+) GATATG/ATAACT 1 -- ds50011Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for HECTD3 (45468212 - 45477027 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HECTD3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HECTD3
    DNA2.0 Custom Variant and Variant Library Synthesis for HECTD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HECTD3 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with HECTD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. (PubMed id 18194665)1, 2 Yu J.... Huang H. (Biochem. Biophys. Res. Commun. 2008)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. The HECTD3 E3 ubiquitin ligase suppresses cisplatin-induced apoptosis via stabilizing MALT1. (PubMed id 23358872)1 Li Y....Chen C. (Neoplasia 2013)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    8. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    9. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79654 HGNC: 26117 AceView: FLJ21156 Ensembl:ENSG00000126107 euGenes: HUgn79654
    ECgene: HECTD3 H-InvDB: HECTD3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HECTD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HECTD3 gene:
    Search GeneIP for patents involving HECTD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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