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Aliases for HECTD3 Gene

Aliases for HECTD3 Gene

  • HECT Domain E3 Ubiquitin Protein Ligase 3 2 3
  • HECT Domain Containing E3 Ubiquitin Protein Ligase 3 2 5
  • HECT Domain-Containing Protein 3 4
  • EC 6.3.2.- 4

External Ids for HECTD3 Gene

Previous GeneCards Identifiers for HECTD3 Gene

  • GC01M045138
  • GC01M045240
  • GC01M045468
  • GC01M043580

Summaries for HECTD3 Gene

Entrez Gene Summary for HECTD3 Gene

  • The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]

GeneCards Summary for HECTD3 Gene

HECTD3 (HECT Domain E3 Ubiquitin Protein Ligase 3) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and syntaxin binding. An important paralog of this gene is HERC2.

UniProtKB/Swiss-Prot for HECTD3 Gene

  • E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECTD3 Gene

Genomics for HECTD3 Gene

Regulatory Elements for HECTD3 Gene

Promoters for HECTD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HECTD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HECTD3 Gene

Chromosome:
1
Start:
45,002,540 bp from pter
End:
45,011,355 bp from pter
Size:
8,816 bases
Orientation:
Minus strand

Genomic View for HECTD3 Gene

Genes around HECTD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HECTD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HECTD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HECTD3 Gene

Proteins for HECTD3 Gene

  • Protein details for HECTD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T447-HECD3_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase HECTD3
    Protein Accession:
    Q5T447
    Secondary Accessions:
    • B3KPV7
    • B3KRH4
    • Q5T448
    • Q9H783

    Protein attributes for HECTD3 Gene

    Size:
    861 amino acids
    Molecular mass:
    97113 Da
    Quaternary structure:
    • Interacts with TRIOBP. Interacts with STX8 (By similarity).
    SequenceCaution:
    • Sequence=BAB15015.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for HECTD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HECTD3 Gene

Proteomics data for HECTD3 Gene at MOPED

Post-translational modifications for HECTD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HECTD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HECTD3 Gene

Domains & Families for HECTD3 Gene

Protein Domains for HECTD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T447

UniProtKB/Swiss-Prot:

HECD3_HUMAN :
  • Contains 1 DOC domain.
Domain:
  • Contains 1 DOC domain.
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
genes like me logo Genes that share domains with HECTD3: view

No data available for Gene Families for HECTD3 Gene

Function for HECTD3 Gene

Molecular function for HECTD3 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).

Enzyme Numbers (IUBMB) for HECTD3 Gene

Gene Ontology (GO) - Molecular Function for HECTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0016874 ligase activity IEA --
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with HECTD3: view
genes like me logo Genes that share phenotypes with HECTD3: view

Animal Models for HECTD3 Gene

MGI Knock Outs for HECTD3:

Animal Model Products

  • Taconic Biosciences Mouse Models for HECTD3

miRNA for HECTD3 Gene

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HECTD3 Gene

Localization for HECTD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HECTD3 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HECTD3 Gene COMPARTMENTS Subcellular localization image for HECTD3 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for HECTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with HECTD3: view

Pathways & Interactions for HECTD3 Gene

genes like me logo Genes that share pathways with HECTD3: view

UniProtKB/Swiss-Prot Q5T447-HECD3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for HECTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with HECTD3: view

No data available for SIGNOR curated interactions for HECTD3 Gene

Drugs & Compounds for HECTD3 Gene

No Compound Related Data Available

Transcripts for HECTD3 Gene

Unigene Clusters for HECTD3 Gene

HECT domain containing E3 ubiquitin protein ligase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HECTD3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP6:
SP7: - -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 15b · 15c ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8: -
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for HECTD3 Gene

GeneLoc Exon Structure for
HECTD3
ECgene alternative splicing isoforms for
HECTD3

Expression for HECTD3 Gene

mRNA expression in normal human tissues for HECTD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HECTD3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0) and Lymph node (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HECTD3 Gene



SOURCE GeneReport for Unigene cluster for HECTD3 Gene Hs.525084

genes like me logo Genes that share expression patterns with HECTD3: view

Protein tissue co-expression partners for HECTD3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HECTD3 Gene

Orthologs for HECTD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HECTD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HECTD3 35
  • 92.68 (n)
  • 98.49 (a)
HECTD3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HECTD3 35
  • 92.14 (n)
  • 98.37 (a)
HECTD3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hectd3 35
  • 90.59 (n)
  • 97.79 (a)
Hectd3 16
Hectd3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HECTD3 35
  • 99.54 (n)
  • 99.77 (a)
HECTD3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hectd3 35
  • 88.02 (n)
  • 93.92 (a)
oppossum
(Monodelphis domestica)
Mammalia HECTD3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 1 (a)
OneToMany
-- 36
  • 1 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 3 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves HECTD3 35
  • 76.17 (n)
  • 81.74 (a)
-- 36
  • 68 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HECTD3 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hectd3 35
  • 66.95 (n)
  • 70.53 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16865 35
zebrafish
(Danio rerio)
Actinopterygii Dr.4430 35
hectd3 35
  • 67.1 (n)
  • 70.17 (a)
hectd3 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HERC2 36
  • 4 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8388 36
  • 5 (a)
ManyToMany
Species with no ortholog for HECTD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HECTD3 Gene

ENSEMBL:
Gene Tree for HECTD3 (if available)
TreeFam:
Gene Tree for HECTD3 (if available)

Paralogs for HECTD3 Gene

Paralogs for HECTD3 Gene

genes like me logo Genes that share paralogs with HECTD3: view

Variants for HECTD3 Gene

Sequence variations from dbSNP and Humsavar for HECTD3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs5869 -- 45,002,936(-) CCCTC(C/T)ACACC utr-variant-3-prime
rs8681 -- 45,002,934(-) CTCCA(C/T)ACCAG utr-variant-3-prime
rs2298006 -- 45,008,485(-) TGAGC(C/T)TTGTG intron-variant
rs2275598 -- 45,009,083(-) ACAGA(C/G)AGTGT intron-variant
rs2275599 -- 45,009,078(-) GAGTG(A/T)GTGTG intron-variant

Variation tolerance for HECTD3 Gene

Residual Variation Intolerance Score: 7.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HECTD3 Gene

HapMap Linkage Disequilibrium report
HECTD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HECTD3 Gene

Disorders for HECTD3 Gene

Relevant External Links for HECTD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HECTD3

No disorders were found for HECTD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HECTD3 Gene

Publications for HECTD3 Gene

  1. The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. (PMID: 18194665) Yu J. … Huang H. (Biochem. Biophys. Res. Commun. 2008) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  5. The HECTD3 E3 ubiquitin ligase suppresses cisplatin-induced apoptosis via stabilizing MALT1. (PMID: 23358872) Li Y. … Chen C. (Neoplasia 2013) 3

Products for HECTD3 Gene

Sources for HECTD3 Gene

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