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Aliases for HECTD3 Gene

Aliases for HECTD3 Gene

  • HECT Domain E3 Ubiquitin Protein Ligase 3 2 3 5
  • HECT Domain Containing E3 Ubiquitin Protein Ligase 3 2
  • HECT-Type E3 Ubiquitin Transferase HECTD3 4
  • HECT Domain-Containing Protein 3 4
  • EC 2.3.2.26 4

External Ids for HECTD3 Gene

Previous GeneCards Identifiers for HECTD3 Gene

  • GC01M045138
  • GC01M045240
  • GC01M045468
  • GC01M043580

Summaries for HECTD3 Gene

Entrez Gene Summary for HECTD3 Gene

  • The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]

GeneCards Summary for HECTD3 Gene

HECTD3 (HECT Domain E3 Ubiquitin Protein Ligase 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and syntaxin binding. An important paralog of this gene is HERC2.

UniProtKB/Swiss-Prot for HECTD3 Gene

  • E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECTD3 Gene

Genomics for HECTD3 Gene

Regulatory Elements for HECTD3 Gene

Enhancers for HECTD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G045009 1.7 Ensembl ENCODE dbSUPER 5.6 -1.0 -1033 5.4 MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 SP3 MEF2D GLIS1 NBN UROD BEST4 HECTD3 BTBD19 TMEM69 GC01P045019
GH01G044818 1.4 ENCODE dbSUPER 5.5 +191.4 191378 2.9 CREB3L1 ZFP64 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D SSRP1 TOE1 DMAP1 GPBP1L1 BEST4 RPS8 UROD HECTD3 BTBD19 RNU5E-6P
GH01G045001 0.7 Ensembl 0.4 +10.1 10055 0.6 CTCF HDGF PKNOX1 RAD21 ZNF121 ARID3A GATA3 EED RELB IKZF2 UROD MRPS17P1 HECTD3
GH01G045002 0.5 ENCODE 0.4 +8.3 8323 1.1 ZNF316 ZNF24 RBFOX2 UROD BEST4 BTBD19 HECTD3 MRPS17P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HECTD3 on UCSC Golden Path with GeneCards custom track

Promoters for HECTD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005825 455 1001 HDGF ARNT ZFP64 ARID4B SIN3A ZNF2 ZNF766 ZNF143 KLF13 SP3
ENSR00000251551 -1245 1201 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1

Genomic Location for HECTD3 Gene

Chromosome:
1
Start:
45,002,540 bp from pter
End:
45,011,355 bp from pter
Size:
8,816 bases
Orientation:
Minus strand

Genomic View for HECTD3 Gene

Genes around HECTD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HECTD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HECTD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HECTD3 Gene

Proteins for HECTD3 Gene

  • Protein details for HECTD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T447-HECD3_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase HECTD3
    Protein Accession:
    Q5T447
    Secondary Accessions:
    • B3KPV7
    • B3KRH4
    • Q5T448
    • Q9H783

    Protein attributes for HECTD3 Gene

    Size:
    861 amino acids
    Molecular mass:
    97113 Da
    Quaternary structure:
    • Interacts with TRIOBP. Interacts with STX8 (By similarity).
    SequenceCaution:
    • Sequence=BAB15015.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for HECTD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HECTD3 Gene

Post-translational modifications for HECTD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HECTD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HECTD3 Gene

Domains & Families for HECTD3 Gene

Protein Domains for HECTD3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HECTD3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HECTD3 Gene

Function for HECTD3 Gene

Molecular function for HECTD3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).

Enzyme Numbers (IUBMB) for HECTD3 Gene

Gene Ontology (GO) - Molecular Function for HECTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding IPI 18194665
GO:0016740 transferase activity IEA --
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with HECTD3: view
genes like me logo Genes that share phenotypes with HECTD3: view

Animal Models for HECTD3 Gene

MGI Knock Outs for HECTD3:

Animal Model Products

  • Taconic Biosciences Mouse Models for HECTD3

CRISPR Products

miRNA for HECTD3 Gene

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HECTD3 Gene

Localization for HECTD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HECTD3 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HECTD3 gene
Compartment Confidence
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for HECTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with HECTD3: view

Pathways & Interactions for HECTD3 Gene

genes like me logo Genes that share pathways with HECTD3: view

UniProtKB/Swiss-Prot Q5T447-HECD3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for HECTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA 18194665
genes like me logo Genes that share ontologies with HECTD3: view

No data available for SIGNOR curated interactions for HECTD3 Gene

Drugs & Compounds for HECTD3 Gene

No Compound Related Data Available

Transcripts for HECTD3 Gene

Unigene Clusters for HECTD3 Gene

HECT domain containing E3 ubiquitin protein ligase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HECTD3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP6:
SP7: - -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 15b · 15c ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8: -
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for HECTD3 Gene

GeneLoc Exon Structure for
HECTD3
ECgene alternative splicing isoforms for
HECTD3

Expression for HECTD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HECTD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HECTD3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0) and Lymph node (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HECTD3 Gene



Protein tissue co-expression partners for HECTD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HECTD3 Gene:

HECTD3

SOURCE GeneReport for Unigene cluster for HECTD3 Gene:

Hs.525084

Evidence on tissue expression from TISSUES for HECTD3 Gene

  • Nervous system(4.8)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with HECTD3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HECTD3 Gene

Orthologs for HECTD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HECTD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HECTD3 34 35
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia HECTD3 34 35
  • 92.68 (n)
dog
(Canis familiaris)
Mammalia HECTD3 34 35
  • 92.14 (n)
oppossum
(Monodelphis domestica)
Mammalia HECTD3 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hectd3 34 16 35
  • 90.59 (n)
rat
(Rattus norvegicus)
Mammalia Hectd3 34
  • 88.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
-- 35
  • 3 (a)
OneToMany
-- 35
  • 1 (a)
OneToMany
-- 35
  • 1 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 80 (a)
OneToMany
HECTD3 34
  • 76.17 (n)
-- 35
  • 68 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HECTD3 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hectd3 34
  • 66.95 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16865 34
zebrafish
(Danio rerio)
Actinopterygii hectd3 34 35
  • 67.1 (n)
Dr.4430 34
fruit fly
(Drosophila melanogaster)
Insecta HERC2 35
  • 4 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8388 35
  • 5 (a)
ManyToMany
Species where no ortholog for HECTD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HECTD3 Gene

ENSEMBL:
Gene Tree for HECTD3 (if available)
TreeFam:
Gene Tree for HECTD3 (if available)

Paralogs for HECTD3 Gene

Paralogs for HECTD3 Gene

genes like me logo Genes that share paralogs with HECTD3: view

Variants for HECTD3 Gene

Sequence variations from dbSNP and Humsavar for HECTD3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs121918060 Pathogenic 45,013,187(+) CTCTC(C/T)TGAGG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs397514764 Pathogenic 45,012,271(+) ATGGA(-/AGCGAATGGG)TTGGG nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs7536892 Likely benign 45,012,132(+) GTCGC(G/T)GGAGT upstream-variant-2KB
rs370067756 Uncertain significance 45,012,215(+) CAGGC(C/T)CAGAT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs41269103 Uncertain significance 45,012,214(+) GCAGG(A/C)TCAGA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HECTD3 Gene

Variant ID Type Subtype PubMed ID
nsv950706 CNV deletion 24416366

Variation tolerance for HECTD3 Gene

Residual Variation Intolerance Score: 7.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HECTD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HECTD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HECTD3 Gene

Disorders for HECTD3 Gene

Relevant External Links for HECTD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HECTD3

No disorders were found for HECTD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HECTD3 Gene

Publications for HECTD3 Gene

  1. The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. (PMID: 18194665) Yu J. … Huang H. (Biochem. Biophys. Res. Commun. 2008) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for HECTD3 Gene

Sources for HECTD3 Gene

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