Aliases for HECTD3 Gene
Aliases for HECTD3 Gene
External Ids for HECTD3 Gene
- HGNC: 26117
- Entrez Gene: 79654
- Ensembl: ENSG00000126107
- UniProtKB: Q5T447
Previous GeneCards Identifiers for HECTD3 Gene
- GC01M045138
- GC01M045240
- GC01M045468
- GC01M043580
Summaries for HECTD3 Gene
-
The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]
GeneCards Summary for HECTD3 Gene
HECTD3 (HECT Domain E3 Ubiquitin Protein Ligase 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and syntaxin binding. An important paralog of this gene is HERC2.
UniProtKB/Swiss-Prot for HECTD3 Gene
-
E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECTD3 Gene
Genomics for HECTD3 Gene
Regulatory Elements for HECTD3 Gene
Enhancers for HECTD3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G045009 | 1.7 | Ensembl ENCODE dbSUPER | 5.6 | -1.0 | -1033 | 5.4 | MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 SP3 MEF2D GLIS1 NBN | UROD BEST4 HECTD3 BTBD19 TMEM69 GC01P045019 |
| GH01G044818 | 1.4 | ENCODE dbSUPER | 5.5 | +191.4 | 191378 | 2.9 | CREB3L1 ZFP64 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D SSRP1 | TOE1 DMAP1 GPBP1L1 BEST4 RPS8 UROD HECTD3 BTBD19 RNU5E-6P |
| GH01G045001 | 0.7 | Ensembl | 0.4 | +10.1 | 10055 | 0.6 | CTCF HDGF PKNOX1 RAD21 ZNF121 ARID3A GATA3 EED RELB IKZF2 | UROD MRPS17P1 HECTD3 |
| GH01G045002 | 0.5 | ENCODE | 0.4 | +8.3 | 8323 | 1.1 | ZNF316 ZNF24 RBFOX2 | UROD BEST4 BTBD19 HECTD3 MRPS17P1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HECTD3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HECTD3 Gene
- Chromosome:
- 1
- Start:
- 45,002,540 bp from pter
- End:
- 45,011,355 bp from pter
- Size:
- 8,816 bases
- Orientation:
- Minus strand
Genomic View for HECTD3 Gene
Genes around HECTD3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.1 by Ensembl
- 1p34.1 by Entrez Gene
- 1p34.1 by HGNC
HECTD3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HECTD3 Gene
Proteins for HECTD3 Gene
-
Protein details for HECTD3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5T447-HECD3_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase HECTD3
- Protein Accession:
- Q5T447
- B3KPV7
- B3KRH4
- Q5T448
- Q9H783
Protein attributes for HECTD3 Gene
- Size:
- 861 amino acids
- Molecular mass:
- 97113 Da
- Quaternary structure:
-
- Interacts with TRIOBP. Interacts with STX8 (By similarity).
- SequenceCaution:
-
- Sequence=BAB15015.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
Protein Expression for HECTD3 Gene
Post-translational modifications for HECTD3 Gene
Other Protein References for HECTD3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HECTD3
-
Abcam antibodies for HECTD3
- Invitrogen Antibodies for HECTD3
- antibodies-online Antibodies for HECTD3: See all 40
- GeneTex HECTD3 antibody for HECTD3
Protein Products
-
OriGene Purified Proteins for HECTD3
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- antibodies-online Proteins for HECTD3: See all 3
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-
Abcam proteins for HECTD3
Assay Products
No data available for DME Specific Peptides for HECTD3 Gene
Domains & Families for HECTD3 Gene
Protein Domains for HECTD3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HECTD3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for HECTD3 Gene
Function for HECTD3 Gene
Molecular function for HECTD3 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).
Enzyme Numbers (IUBMB) for HECTD3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | ISS | -- |
| GO:0005515 | protein binding | IPI | 18194665 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0019905 | syntaxin binding | IEA | -- |
Phenotypes for HECTD3 Gene
- MGI mutant phenotypes for HECTD3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HECTD3:
Animal Models for HECTD3 Gene
- MGI Knock Outs for HECTD3:
-
- Hectd3 tm1(NCOM)Cmhd
Animal Model Products
-
Taconic Biosciences Mouse Models for HECTD3
-
ViGene Biosciences lentiviral particle packaged cDNA for HECTD3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HECTD3 gene
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CRISPR Products
-
OriGene CRISPR knockouts for HECTD3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HECTD3
- GenScript: Design CRISPR guide RNA sequences for HECTD3
miRNA for HECTD3 Gene
- miRTarBase miRNAs that target HECTD3
-
- hsa-mir-122-5p (MIRT023327)
- hsa-mir-7-5p (MIRT025780)
- hsa-mir-26b-5p (MIRT029557)
- hsa-mir-615-3p (MIRT039878)
- hsa-mir-484 (MIRT041762)
- hsa-mir-4755-3p (MIRT138483)
- hsa-mir-4459 (MIRT455926)
- hsa-mir-486-3p (MIRT455927)
- hsa-mir-6721-5p (MIRT455928)
- hsa-mir-4722-5p (MIRT455929)
- hsa-mir-6087 (MIRT455930)
- hsa-mir-219a-2-3p (MIRT455931)
- hsa-mir-1247-3p (MIRT455932)
- hsa-mir-4768-3p (MIRT455933)
- hsa-mir-6513-5p (MIRT667966)
- hsa-mir-887-5p (MIRT667967)
- hsa-mir-3913-5p (MIRT667968)
- hsa-mir-3122 (MIRT667969)
- hsa-mir-450a-1-3p (MIRT667970)
- hsa-mir-6780a-5p (MIRT667971)
- hsa-mir-6779-5p (MIRT667972)
- hsa-mir-3689c (MIRT667973)
- hsa-mir-3689b-3p (MIRT667974)
- hsa-mir-3689a-3p (MIRT667975)
- hsa-mir-30b-3p (MIRT667976)
- hsa-mir-1273h-5p (MIRT667977)
- hsa-mir-6788-5p (MIRT667978)
- hsa-mir-30c-2-3p (MIRT667979)
- hsa-mir-30c-1-3p (MIRT667980)
- hsa-mir-7977 (MIRT667981)
- hsa-mir-6799-5p (MIRT667982)
- hsa-mir-6883-5p (MIRT667983)
- hsa-mir-6785-5p (MIRT667984)
- hsa-mir-4728-5p (MIRT667985)
- hsa-mir-149-3p (MIRT667986)
- hsa-mir-7106-5p (MIRT667987)
- hsa-mir-3166 (MIRT667988)
- hsa-mir-383-3p (MIRT667989)
- hsa-mir-1288-5p (MIRT667990)
- hsa-mir-1324 (MIRT667991)
- hsa-mir-6511a-5p (MIRT667992)
- hsa-mir-1910-3p (MIRT667993)
- hsa-mir-3714 (MIRT667994)
- hsa-mir-6514-3p (MIRT674623)
- hsa-mir-24-3p (MIRT674624)
- hsa-mir-4284 (MIRT674625)
- hsa-mir-6847-3p (MIRT674626)
- hsa-mir-6811-3p (MIRT674627)
- hsa-mir-214-5p (MIRT674628)
- hsa-mir-5693 (MIRT674629)
- hsa-mir-26a-5p (MIRT727508)
miRNA Products
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Inhibitory RNA Products
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Clone Products
-
OriGene ORF clones in human for HECTD3
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Cell Line Products
-
Horizon Cell Lines for HECTD3
-
ViGene Biosciences adenoviral particle packaged cDNA for HECTD3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HECTD3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HECTD3 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HECTD3 Gene
Localization for HECTD3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HECTD3 Gene
- Cytoplasm, perinuclear region.
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0048471 | perinuclear region of cytoplasm | ISS | -- |
Pathways & Interactions for HECTD3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for HECTD3 Gene
4 Reactome pathways for HECTD3 Gene
UniProtKB/Swiss-Prot Q5T447-HECD3_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for HECTD3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IDA | 18194665 |
No data available for SIGNOR curated interactions for HECTD3 Gene
Transcripts for HECTD3 Gene
mRNA/cDNA for HECTD3 Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (222) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HECTD3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HECTD3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HECTD3
- GenScript: Design CRISPR guide RNA sequences for HECTD3
miRNA Products
- Search ViGene Biosciences for HECTD3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HECTD3
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-
ViGene Biosciences ready-to-package AAV shRNAs for HECTD3 gene
Clone Products
-
OriGene ORF clones in human for HECTD3
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 15b | · | 15c | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||
| SP10: | |||||||||||||||||||||
| SP11: | |||||||||||||||||||||
| SP12: |
Expression for HECTD3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (13.0) and Lymph node (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HECTD3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HECTD3 Gene:
HECTD3SOURCE GeneReport for Unigene cluster for HECTD3 Gene:
Hs.525084Evidence on tissue expression from TISSUES for HECTD3 Gene
- Nervous system(4.8)
- Muscle(4.3)
Primer Products
-
OriGene qPCR primer pairs for HECTD3
-
OriGene qPCR primer pairs and template standards for HECTD3
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HECTD3 Gene
Orthologs for HECTD3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HECTD3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HECTD3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HECTD3 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HECTD3 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hectd3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hectd3 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| HECTD3 34 |
|
||||
| -- 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | HECTD3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hectd3 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16865 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hectd3 34 35 |
|
||
| Dr.4430 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | HERC2 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8388 35 |
|
ManyToMany |
- Species where no ortholog for HECTD3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HECTD3 Gene
Variants for HECTD3 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs121918060 | Pathogenic | 45,013,187(+) | CTCTC(C/T)TGAGG | nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime | |
| rs397514764 | Pathogenic | 45,012,271(+) | ATGGA(-/AGCGAATGGG)TTGGG | nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime | |
| rs7536892 | Likely benign | 45,012,132(+) | GTCGC(G/T)GGAGT | upstream-variant-2KB | |
| rs370067756 | Uncertain significance | 45,012,215(+) | CAGGC(C/T)CAGAT | nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs41269103 | Uncertain significance | 45,012,214(+) | GCAGG(A/C)TCAGA | nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime |
Residual Variation Intolerance Score:
7.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.62;
72.60% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HECTD3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HECTD3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HECTD3 Gene
Disorders for HECTD3 Gene
Relevant External Links for HECTD3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HECTD3
No disorders were found for HECTD3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HECTD3 Gene
Publications for HECTD3 Gene
- The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. (PMID: 18194665) Yu J. … Huang H. (Biochem. Biophys. Res. Commun. 2008) 2 3 4 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
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- Humanized Mice
- antibodies-online Antibodies for HECTD3: See all 40
- Search antibodies-online for kits
- antibodies-online Proteins for HECTD3: See all 3
- Search antibodies-online for peptides
- GeneTex HECTD3 antibody for HECTD3
- Search GeneTex for Proteins for HECTD3
- ViGene Biosciences adenoviral particle packaged cDNA for HECTD3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HECTD3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HECTD3 gene
- Search ViGene Biosciences for HECTD3
- Horizon Cell Lines for HECTD3
- Cyagen custom Knockout/knockin (KOKI) mouse models for HECTD3
- VectorBuilder custom plasmid, inducible vectors for HECTD3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HECTD3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HECTD3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer