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Aliases for HECTD2 Gene

Aliases for HECTD2 Gene

  • HECT Domain Containing E3 Ubiquitin Protein Ligase 2 2 3
  • HECT Domain-Containing Protein 2 4
  • HECT Domain Containing 2 2
  • EC 6.3.2.- 4

External Ids for HECTD2 Gene

Previous GeneCards Identifiers for HECTD2 Gene

  • GC10P092835
  • GC10P093160
  • GC10P086798

Summaries for HECTD2 Gene

GeneCards Summary for HECTD2 Gene

HECTD2 (HECT Domain Containing E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Diseases associated with HECTD2 include alzheimer disease. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is HERC5.

UniProtKB/Swiss-Prot for HECTD2 Gene

  • Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECTD2 Gene

Genomics for HECTD2 Gene

Regulatory Elements for HECTD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HECTD2 Gene

Start:
91,409,280 bp from pter
End:
91,514,829 bp from pter
Size:
105,550 bases
Orientation:
Plus strand

Genomic View for HECTD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HECTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HECTD2 Gene

Proteins for HECTD2 Gene

  • Protein details for HECTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5U5R9-HECD2_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase HECTD2
    Protein Accession:
    Q5U5R9
    Secondary Accessions:
    • Q5VZ97
    • Q5VZ98
    • Q5VZ99
    • Q8N1X7
    • Q8TCP5

    Protein attributes for HECTD2 Gene

    Size:
    776 amino acids
    Molecular mass:
    88122 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HECTD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HECTD2 Gene

Proteomics data for HECTD2 Gene at MOPED

Post-translational modifications for HECTD2 Gene

  • Ubiquitination at Lys53
  • Modification sites at PhosphoSitePlus

Other Protein References for HECTD2 Gene

No data available for DME Specific Peptides for HECTD2 Gene

Domains for HECTD2 Gene

Protein Domains for HECTD2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5U5R9

UniProtKB/Swiss-Prot:

HECD2_HUMAN :
  • Q5U5R9
Domain:
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
genes like me logo Genes that share domains with HECTD2: view

No data available for Gene Families for HECTD2 Gene

Function for HECTD2 Gene

Molecular function for HECTD2 Gene

UniProtKB/Swiss-Prot Function: Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for HECTD2 Gene

Gene Ontology (GO) - Molecular Function for HECTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with HECTD2: view

Phenotypes for HECTD2 Gene

genes like me logo Genes that share phenotypes with HECTD2: view

Animal Model Products

CRISPR Products

miRNA for HECTD2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HECTD2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for HECTD2 Gene

Localization for HECTD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HECTD2 Gene COMPARTMENTS Subcellular localization image for HECTD2 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for HECTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with HECTD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HECTD2 Gene

Pathways for HECTD2 Gene

SuperPathways for HECTD2 Gene

No Data Available

UniProtKB/Swiss-Prot Q5U5R9-HECD2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for HECTD2 Gene

Gene Ontology (GO) - Biological Process for HECTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with HECTD2: view

No data available for Pathways by source for HECTD2 Gene

Transcripts for HECTD2 Gene

Unigene Clusters for HECTD2 Gene

HECT domain containing E3 ubiquitin protein ligase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HECTD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HECTD2 Gene

No ASD Table

Relevant External Links for HECTD2 Gene

GeneLoc Exon Structure for
HECTD2
ECgene alternative splicing isoforms for
HECTD2

Expression for HECTD2 Gene

mRNA expression in normal human tissues for HECTD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HECTD2 Gene

SOURCE GeneReport for Unigene cluster for HECTD2 Gene Hs.596096

genes like me logo Genes that share expressions with HECTD2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HECTD2 Gene

Orthologs for HECTD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HECTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HECTD2 35
  • 99.7 (n)
  • 100 (a)
HECTD2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HECTD2 35
  • 92.77 (n)
  • 93.03 (a)
HECTD2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HECTD2 35
  • 93.43 (n)
  • 92.78 (a)
HECTD2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hectd2 35
  • 89.15 (n)
  • 89.66 (a)
Hectd2 16
Hectd2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HECTD2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HECTD2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hectd2 35
  • 90.78 (n)
  • 90.31 (a)
chicken
(Gallus gallus)
Aves HECTD2 35
  • 81.24 (n)
  • 83.97 (a)
HECTD2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HECTD2 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hectd2 35
  • 76.89 (n)
  • 82.4 (a)
zebrafish
(Danio rerio)
Actinopterygii hectd2 35
  • 70.66 (n)
  • 75.74 (a)
hectd2 36
  • 74 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUL4 36
  • 22 (a)
OneToMany
HUL4 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6373 35
Species with no ortholog for HECTD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HECTD2 Gene

ENSEMBL:
Gene Tree for HECTD2 (if available)
TreeFam:
Gene Tree for HECTD2 (if available)

Paralogs for HECTD2 Gene

Paralogs for HECTD2 Gene

Selected SIMAP similar genes for HECTD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HECTD2: view

Variants for HECTD2 Gene

Sequence variations from dbSNP and Humsavar for HECTD2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
VAR_026836 -

Structural Variations from Database of Genomic Variants (DGV) for HECTD2 Gene

Variant ID Type Subtype PubMed ID
nsv7488 CNV Insertion 18451855
nsv7208 OTHER Inversion 18451855
esv2189509 CNV Deletion 18987734
dgv801n71 CNV Loss 21882294
nsv895891 CNV Loss 21882294
esv1003018 OTHER Inversion 20482838
nsv436654 OTHER Inversion 17901297
esv2421381 CNV Duplication 20811451
nsv433413 CNV Gain 18776910
esv1767604 OTHER Inversion 17803354
esv33149 CNV Loss 17666407

Relevant External Links for HECTD2 Gene

HapMap Linkage Disequilibrium report
HECTD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HECTD2 Gene

Disorders for HECTD2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HECTD2 Gene including...

Search for HECTD2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for HECTD2 Gene

Relevant External Links for HECTD2

Genetic Association Database (GAD)
HECTD2
Human Genome Epidemiology (HuGE) Navigator
HECTD2
genes like me logo Genes that share disorders with HECTD2: view

No data available for UniProtKB/Swiss-Prot for HECTD2 Gene

Publications for HECTD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3

Products for HECTD2 Gene

Sources for HECTD2 Gene

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