Aliases for HECTD2 Gene
Aliases for HECTD2 Gene
External Ids for HECTD2 Gene
- HGNC: 26736
- Entrez Gene: 143279
- Ensembl: ENSG00000165338
- UniProtKB: Q5U5R9
Previous GeneCards Identifiers for HECTD2 Gene
- GC10P092835
- GC10P093160
- GC10P086798
Summaries for HECTD2 Gene
GeneCards Summary for HECTD2 Gene
HECTD2 (HECT Domain E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is UBE3A.
UniProtKB/Swiss-Prot for HECTD2 Gene
-
Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECTD2 Gene
Genomics for HECTD2 Gene
Regulatory Elements for HECTD2 Gene
Enhancers for HECTD2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HECTD2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HECTD2 Gene
- Chromosome:
- 10
- Start:
- 91,409,280 bp from pter
- End:
- 91,514,829 bp from pter
- Size:
- 105,550 bases
- Orientation:
- Plus strand
Genomic View for HECTD2 Gene
Genes around HECTD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q23.32 by Ensembl
- 10q23.32 by Entrez Gene
- 10q23.32 by HGNC
HECTD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HECTD2 Gene
Proteins for HECTD2 Gene
-
Protein details for HECTD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5U5R9-HECD2_HUMAN
- Recommended name:
- Probable E3 ubiquitin-protein ligase HECTD2
- Protein Accession:
- Q5U5R9
- Q5VZ97
- Q5VZ98
- Q5VZ99
- Q8N1X7
- Q8TCP5
Protein attributes for HECTD2 Gene
- Size:
- 776 amino acids
- Molecular mass:
- 88122 Da
- Quaternary structure:
- No Data Available
Protein Expression for HECTD2 Gene
Post-translational modifications for HECTD2 Gene
Other Protein References for HECTD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HECTD2
- Invitrogen Antibodies for HECTD2
- antibodies-online Antibodies for HECTD2: See all 51
- GeneTex HECTD2 antibody for HECTD2
Protein Products
-
OriGene Purified Proteins for HECTD2
- Search Origene for MassSpec and Protein Over-expression Lysates for HECTD2
- Origene Custom Protein Services for HECTD2
- antibodies-online Proteins for HECTD2: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HECTD2
Assay Products
No data available for DME Specific Peptides for HECTD2 Gene
Domains & Families for HECTD2 Gene
Protein Domains for HECTD2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HECTD2 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for HECTD2 Gene
Function for HECTD2 Gene
Molecular function for HECTD2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
- UniProtKB/Swiss-Prot Function:
- Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Enzyme Numbers (IUBMB) for HECTD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS,IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for HECTD2 Gene
- MGI mutant phenotypes for HECTD2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HECTD2:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased cell death HMECs cells
- Increased cilium length after serum starvation
Animal Models for HECTD2 Gene
- MGI Knock Outs for HECTD2:
-
- Hectd2 tm1b(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HECTD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HECTD2 gene
- Search ViGene Biosciences for HECTD2
CRISPR Products
-
OriGene CRISPR knockouts for HECTD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HECTD2
- GenScript: Design CRISPR guide RNA sequences for HECTD2
miRNA for HECTD2 Gene
- miRTarBase miRNAs that target HECTD2
miRNA Products
- Search ViGene Biosciences for HECTD2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HECTD2
- Browse OriGene Inhibitory RNA Products For HECTD2
-
ViGene Biosciences ready-to-package AAV shRNAs for HECTD2 gene
Cell Line Products
-
Horizon Cell Lines for HECTD2
-
ViGene Biosciences adenoviral particle packaged cDNA for HECTD2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HECTD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HECTD2 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HECTD2 Gene
Localization for HECTD2 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 3 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for HECTD2 Gene
Pathways & Interactions for HECTD2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for HECTD2 Gene
4 Reactome pathways for HECTD2 Gene
UniProtKB/Swiss-Prot Q5U5R9-HECD2_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for HECTD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
No data available for SIGNOR curated interactions for HECTD2 Gene
Transcripts for HECTD2 Gene
mRNA/cDNA for HECTD2 Gene
- (7) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (80) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HECTD2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HECTD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HECTD2
- GenScript: Design CRISPR guide RNA sequences for HECTD2
miRNA Products
- Search ViGene Biosciences for HECTD2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HECTD2
- Browse OriGene Inhibitory RNA Products For HECTD2
-
ViGene Biosciences ready-to-package AAV shRNAs for HECTD2 gene
Flow Cytometry Products
Expression for HECTD2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Oligodendrocytes (Nervous System)
- Brain (Nervous System)
- Spinal Cord (Nervous System)
This gene is overexpressed in Platelet (32.8) and Heart (31.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HECTD2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HECTD2 Gene:
HECTD2SOURCE GeneReport for Unigene cluster for HECTD2 Gene:
Hs.596096Evidence on tissue expression from TISSUES for HECTD2 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for HECTD2
-
OriGene qPCR primer pairs for HECTD2
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HECTD2 Gene
Orthologs for HECTD2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HECTD2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HECTD2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HECTD2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hectd2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hectd2 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HECTD2 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HECTD2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HECTD2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HECTD2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hectd2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hectd2 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HUL4 35 37 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.6373 34 |
|
- Species where no ortholog for HECTD2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HECTD2 Gene
(13) SIMAP similar genes for HECTD2 Gene using alignment to 4 proteins:
Variants for HECTD2 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000018277 | -- | 91,420,328(+) | CATTT(A/G)TAATC | intron-variant | |
| rs1000019188 | -- | 91,480,561(+) | ACAAA(A/G)GCTCT | intron-variant | |
| rs1000031444 | -- | 91,490,771(+) | CTGTA(A/G)TCCCA | intron-variant | |
| rs1000043372 | -- | 91,446,237(+) | ACAGG(A/G)TCTGG | intron-variant | |
| rs1000146243 | -- | 91,467,531(+) | CCCTC(A/G)ATGCC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1003018 | OTHER | inversion | 20482838 |
| esv1767604 | OTHER | inversion | 17803354 |
| esv2189509 | CNV | deletion | 18987734 |
| esv2421381 | CNV | duplication | 20811451 |
| esv33149 | CNV | loss | 17666407 |
| esv3345260 | OTHER | inversion | 20981092 |
| esv3546676 | CNV | deletion | 23714750 |
| esv3624207 | CNV | loss | 21293372 |
| nsv1040403 | CNV | gain | 25217958 |
| nsv433413 | CNV | gain | 18776910 |
| nsv436654 | OTHER | inversion | 17901297 |
| nsv551913 | CNV | loss | 21841781 |
| nsv7208 | OTHER | inversion | 18451855 |
| nsv7488 | CNV | insertion | 18451855 |
| nsv948134 | CNV | duplication | 23825009 |
| nsv950993 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.21;
24.26% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HECTD2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HECTD2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HECTD2 Gene
Disorders for HECTD2 Gene
Relevant External Links for HECTD2
No disorders were found for HECTD2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HECTD2 Gene
Publications for HECTD2 Gene
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3 64
Products for HECTD2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Immunoprecipitation Assays
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HECTD2
- Search Origene for MassSpec and Protein Over-expression Lysates for HECTD2
- Origene Custom Protein Services for HECTD2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HECTD2
- Browse OriGene Inhibitory RNA Products For HECTD2
- OriGene qPCR primer pairs and template standards for HECTD2
- OriGene qPCR primer pairs for HECTD2
- OriGene CRISPR knockouts for HECTD2
- OriGene ORF clones in human for HECTD2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for HECTD2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HECTD2
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- GenScript: Design CRISPR guide RNA sequences for HECTD2
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- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HECTD2
- Novus Biologicals proteins and lysates for HECTD2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for HECTD2: See all 51
- Search antibodies-online for kits
- antibodies-online Proteins for HECTD2: See all 6
- Search antibodies-online for peptides
- GeneTex HECTD2 antibody for HECTD2
- Search GeneTex for Proteins for HECTD2
- ViGene Biosciences adenoviral particle packaged cDNA for HECTD2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HECTD2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HECTD2 gene
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- Horizon Cell Lines for HECTD2
- Cyagen custom Knockout/knockin (KOKI) mouse models for HECTD2
- VectorBuilder custom plasmid, inducible vectors for HECTD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HECTD2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HECTD2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (122) diseasecard
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer