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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HECTD1 Gene

protein-coding   GIFtS: 48
GCID: GC14M031569

HECT domain containing E3 ubiquitin protein ligase 1

(Previous name: HECT domain containing 1 )
  Search for HECTD1
in our new
 Human Malady Compendium 
Biological research products
for HECTD1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
HECT Domain Containing E3 Ubiquitin Protein Ligase 11 2     E3 Ligase For Inhibin Receptor2 3
HECT Domain Containing 11 2     HECT Domain-Containing Protein 12 3
KIAA11311 3     E3 Ubiquitin-Protein Ligase HECTD12
EULIR2 3     EC 6.3.2.-3

External Ids:    HGNC: 201571   Entrez Gene: 258312   Ensembl: ENSG000000921487   UniProtKB: Q9ULT83   

Export aliases for HECTD1 gene to outside databases

Previous GC identifers: GC14M025356 GC14M029559 GC14M030639 GC14M011686


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: HECD1_HUMAN, Q9ULT8
Function: Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the
form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development
of the head mesenchyme and neural tube closure (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HECTD1 gene promoter:
         FOXD3   AP-2gamma   HEN1   POU2F1   POU2F1a   Chx10   AP-2beta   AP-2alpha   ATF   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHECTD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HECTD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HECTD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q12

HECTD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HECTD1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M031569:  view genomic region     (about GC identifiers)

Start:
31,569,318 bp from pter      End:
31,677,010 bp from pter
Size:
107,693 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HECD1_HUMAN, Q9ULT8 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase HECTD1  
Size: 2610 amino acids; 289384 Da
Subunit: Interacts with IGSF1
3 PDB 3D structures from and Proteopedia for HECTD1:
2DK3 (3D)        2LC3 (3D)        3DKM (3D)    
Secondary accessions: D3DS86 Q6P445 Q86VJ1 Q96F34 Q9UFZ7

Explore the universe of human proteins at neXtProt for HECTD1: NX_Q9ULT8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULT8

  • HECTD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056197.2  
    ENSEMBL proteins: 
     ENSP00000451260   ENSP00000450697   ENSP00000451860   ENSP00000450920   ENSP00000452233  
     ENSP00000452015   ENSP00000382269  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HECTD1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IBA--


    HECTD1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HECTD1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HECTD1 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR012919 Sad1_UNC_C
     IPR011989 ARM-like
     IPR000569 HECT
     IPR002110 Ankyrin_rpt
     IPR008979 Galactose-bd-like

    Graphical View of Domain Structure for InterPro Entry Q9ULT8

    ProtoNet protein and cluster: Q9ULT8

    3 Blocks protein families:
    IPB000569 HECT domain (Ubiquitin-protein ligase)
    IPB010606 Mib_herc2
    IPB012919 Sad1/UNC-like


    UniProtKB/Swiss-Prot: HECD1_HUMAN, Q9ULT8
    Similarity: Belongs to the UPL family. K-HECT subfamily
    Similarity: Contains 4 ANK repeats
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 1 MIB/HERC2 domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HECD1_HUMAN, Q9ULT8
    Function: Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the
    form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development
    of the head mesenchyme and neural tube closure (By similarity)

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HECTD1
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate HECTD1 (see all 42):
    hsa-miR-300 hsa-miR-1224-3p hsa-miR-15a hsa-miR-200a hsa-miR-128 hsa-miR-503 hsa-miR-374a hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidHECTD1 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IBA--
    GO:0005515protein binding IPI12421765
    GO:0046872metal ion binding IEA--


    HECTD1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for HECTD1:
     Increased HPV18 LCR reporter a  Increased homologous recombina 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hectd1):
     craniofacial  embryogenesis  mortality/aging  nervous system  skeleton 
     vision/eye 

    HECTD1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: HECD1_HUMAN, Q9ULT8
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HECTD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/38 Interacting proteins for HECTD1 (Q9ULT82, 3 ENSP000003822694) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZRANB1Q9UGI03, ENSP000003526764I2D: score=2 STRING: ENSP00000352676
    UVRAGQ9P2Y53, ENSP000003484554I2D: score=1 STRING: ENSP00000348455
    IGSF1Q8N6C53, ENSP000003550104I2D: score=3 STRING: ENSP00000355010
    DDX56Q9NY933, ENSP000002587724I2D: score=1 STRING: ENSP00000258772
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure IEA--
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA--


    HECTD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HECTD1
    Search CenterWatch for drugs/clinical trials and news about HECTD1 / HECD1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HECTD1 gene: 
    NM_015382.2  

    Unigene Cluster for HECTD1:

    HECT domain containing E3 ubiquitin protein ligase 1
    Hs.708017  [show with all ESTs]
    Unigene Representative Sequence: NM_015382
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554882 ENST00000555843(uc001wra.1) ENST00000553700(uc001wrb.1 uc001wrd.1)
    ENST00000556281 ENST00000557695 ENST00000555311 ENST00000553957 ENST00000557321
    ENST00000554027 ENST00000555915 ENST00000556004 ENST00000557369 ENST00000554850
    ENST00000556224 ENST00000554471 ENST00000553616 ENST00000556474(uc001wre.3)
    ENST00000399332(uc001wrc.1)

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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate HECTD1 (see all 42):
    hsa-miR-300 hsa-miR-1224-3p hsa-miR-15a hsa-miR-200a hsa-miR-128 hsa-miR-503 hsa-miR-374a hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidHECTD1 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HECTD1 (see all 3)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HECTD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HECTD1

    Additional cDNA sequence: 

    AB032957.2 AK024847.1 AK095634.1 AK125788.1 AL110222.1 AY739714.1 BC006237.2 BC011658.2 
    BC016947.1 BC063686.1 BC072441.1 BC083494.1 

    24/27 DOTS entries (see all 27):

    DT.100026392  DT.100649858  DT.100658615  DT.92442016  DT.100026391  DT.92442014  DT.99989930  DT.120763700 
    DT.92442015  DT.95209144  DT.120763757  DT.91868809  DT.120763673  DT.91905375  DT.100658610  DT.120763734 
    DT.120763748  DT.40295355  DT.435879  DT.92016762  DT.95116352  DT.95347887  DT.97787945  DT.120763703 

    24/307 AceView cDNA sequences (see all 307):

    BC063686 CB114558 BE932309 AI141536 BU623991 AL110222 AA716179 BU156007 
    AW502290 AA825680 CA435618 BG397850 BF061544 AI638212 BQ027113 AA877508 
    BG289175 CD676191 AA732634 BU101681 AW576535 BI089119 AI628442 AB032957 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HECTD1 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^
    SP1:                                                                                -     -                 -                                         -         
    SP2:                                                                                                        -                                         -         
    SP3:                                      -                                         -     -                 -                                         -         
    SP4:                                                                                -                       -                                                   
    SP5:                                                                                -     -                 -                                                   

    ExUns: 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25
    SP1:                                                                                -               
    SP2:                                                                                -               
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for HECTD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HECTD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACCAAACTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See HECTD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HECTD1

    SOURCE GeneReport for Unigene cluster: Hs.708017
        SABiosciences Expression via Pathway-Focused PCR Array including HECTD1: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HECTD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HECTD1 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves HECTD11 HECT domain containing 1 86.49(n)
    97.08(a)
      423310  XM_421227.3  XP_421227.3 
    lizard
    (Anolis carolinensis)
    Reptilia HECTD16
    --
    95(a)
    1 ↔ 1
    2(56901043-56969242)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.190912 Xenopus laevis transcribed sequence with moderate similarity more 75.12(n)    BX847405.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hectd12 HECT domain containing 1 76.25(n)   368729  57052289 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56041 CG5604 55.21(n)
    57.08(a)
      34378  NM_135525.1  NP_609369.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hecd-11 Protein HECD-1 49.33(n)
    43.11(a)
      177486  NM_068719.2  NP_501120.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UPL46
    KAK6
    E3 ubiquitin-protein ligase UPL3
    22(a)
    20(a)
    1 ↔ many
    1 ↔ many
    5(662064-669107)
    4(18041031-18049292)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 3)
    HECT-domain domain containing protein, expressed
    (see all 3)
    37(a)
    25(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    5(22713478-22716547)
    2(86464-91606)


    ENSEMBL Gene Tree for HECTD1 (if available)
    TreeFam Gene Tree for HECTD1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HECTD1 gene
    TRIP122  
    12 SIMAP similar genes for HECTD1 using alignment to 8 protein entries:     HECD1_HUMAN (see all proteins):
    NEDD4L    NEDD4    HACE1    SMURF2    UBE3C    GABPB1
    KIAA0317    ANKRD54    UBE3A    HECTD2    WWP2    HUWE1

    HECTD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1865 NCBI SNPs in HECTD1 are shown (see all 1865    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882545981,2
    --31568896(+) CTGGAA/TTTTGG 1 -- ds50010--------
    rs1484953931,2
    --31568904(+) TGGAAA/GATCTA 1 -- ds50010--------
    rs1418446541,2
    --31568955(+) AAACAC/GCGGTA 1 -- ds50010--------
    rs1170121751,2
    F,--31568957(+) ACAGCG/AGTATC 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs2002173641,2
    --31569065(+) TGGTG-/TTTTTT 1 -- ds50010--------
    rs101378521,2
    C,F,A,H,--31569071(+) TTTTTA/TAAAAA 1 -- ds50018Minor allele frequency- T:0.46NA WA EA 368
    rs2010590781,2
    --31569071(+) TTTTT-/AAAAAA 1 -- ds50010--------
    rs1506319931,2
    --31569229(+) AGTAAC/TTTCAG 1 -- ds50010--------
    rs1814319071,2
    --31569273(+) GCTAAA/GGCTCT 1 -- ds50010--------
    rs37429211,2
    C,F,H,--31569385(+) TCAAAC/TGGCAA 1 -- ut3112Minor allele frequency- T:0.05NS EA NA 1070

    HapMap Linkage Disequilibrium report for HECTD1 (31569318 - 31677010 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for HECTD1
         2 CNVs: 7031 39150

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HECTD1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with HECTD1)
        Utopia: connect your pdf to the dynamic
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    1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2, 3 Hirosawa M.... Ohara O. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. (PubMed id 12421765)1, 2 Nakayama M....Ohara O. (2002)
    4. Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25831 HGNC: 20157 AceView: HECTD1 Ensembl:ENSG00000092148 euGenes: HUgn25831
    ECgene: HECTD1 H-InvDB: HECTD1

    (According to HUGE)
    About This Section
    HUGE: KIAA1131

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HECTD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HECTD1 gene:
    Search GeneIP for patents involving HECTD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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