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Aliases for HECTD1 Gene

Aliases for HECTD1 Gene

  • HECT Domain Containing E3 Ubiquitin Protein Ligase 1 2 3
  • HECT Domain-Containing Protein 1 3 4
  • E3 Ligase For Inhibin Receptor 3 4
  • EULIR 3 4
  • E3 Ubiquitin-Protein Ligase HECTD1 3
  • HECT Domain Containing 1 2
  • EC 6.3.2.- 4
  • KIAA1131 4

External Ids for HECTD1 Gene

Summaries for HECTD1 Gene

GeneCards Summary for HECTD1 Gene

HECTD1 (HECT Domain Containing E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is TRIP12.

UniProtKB/Swiss-Prot for HECTD1 Gene

  • Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECTD1 Gene

Genomics for HECTD1 Gene

Genomic Location for HECTD1 Gene

Start:
31,100,112 bp from pter
End:
31,208,060 bp from pter
Size:
107,949 bases
Orientation:
Minus strand

Genomic View for HECTD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HECTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HECTD1 Gene

Regulatory Elements for HECTD1 Gene

Proteins for HECTD1 Gene

  • Protein details for HECTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULT8-HECD1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase HECTD1
    Protein Accession:
    Q9ULT8
    Secondary Accessions:
    • D3DS86
    • Q6P445
    • Q86VJ1
    • Q96F34
    • Q9UFZ7

    Protein attributes for HECTD1 Gene

    Size:
    2610 amino acids
    Molecular mass:
    289384 Da
    Quaternary structure:
    • Interacts with IGSF1.

    Three dimensional structures from OCA and Proteopedia for HECTD1 Gene

neXtProt entry for HECTD1 Gene

Proteomics data for HECTD1 Gene at MOPED

Post-translational modifications for HECTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys229, Lys255, Lys522, Lys1272, Lys1287, Lys1371, Lys1768, Lys1919, Lys2268, and Lys2605

No data available for DME Specific Peptides for HECTD1 Gene

Domains for HECTD1 Gene

Gene Families for HECTD1 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

UniProtKB/Swiss-Prot:

HECD1_HUMAN
Domain:
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.:
    • Q9ULT8
  • Contains 1 MIB/HERC2 domain.:
    • Q9ULT8
Family:
  • Belongs to the UPL family. K-HECT subfamily.:
    • Q9ULT8
Similarity:
  • Contains 4 ANK repeats.:
    • Q9ULT8
genes like me logo Genes that share domains with HECTD1: view

Function for HECTD1 Gene

Molecular function for HECTD1 Gene

UniProtKB/Swiss-Prot Function: Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity).

Enzyme Numbers (IUBMB) for HECTD1 Gene

Gene Ontology (GO) - Molecular Function for HECTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0005488 binding --
GO:0005515 protein binding IPI 12421765
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HECTD1: view
genes like me logo Genes that share phenotypes with HECTD1: view

miRNA for HECTD1 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for HECTD1 Gene

Localization for HECTD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HECTD1 Gene COMPARTMENTS Subcellular localization image for HECTD1 gene
Compartment Confidence
cytosol 3
nucleus 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HECTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with HECTD1: view

Pathways for HECTD1 Gene

SuperPathways for HECTD1 Gene

No Data Available

UniProtKB/Swiss-Prot Q9ULT8-HECD1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for HECTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA --
GO:0016567 protein ubiquitination --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with HECTD1: view

No data available for Pathways by source for HECTD1 Gene

Transcripts for HECTD1 Gene

Unigene Clusters for HECTD1 Gene

HECT domain containing E3 ubiquitin protein ligase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HECTD1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8:
SP9:
SP10:

ExUns: 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for HECTD1 Gene

GeneLoc Exon Structure for
HECTD1
ECgene alternative splicing isoforms for
HECTD1

Expression for HECTD1 Gene

mRNA expression in normal human tissues for HECTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HECTD1 Gene

This gene is overexpressed in Muscle - Skeletal (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HECTD1 Gene

SOURCE GeneReport for Unigene cluster for HECTD1 Gene Hs.708017

genes like me logo Genes that share expressions with HECTD1: view

Orthologs for HECTD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HECTD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HECTD1 36
  • 99.81 (n)
  • 99.96 (a)
HECTD1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HECTD1 36
  • 95.07 (n)
  • 99.62 (a)
HECTD1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HECTD1 36
  • 95.15 (n)
  • 99.46 (a)
HECTD1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hectd1 36
  • 91.85 (n)
  • 98.89 (a)
Hectd1 16
Hectd1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HECTD1 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HECTD1 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hectd1 36
  • 91.71 (n)
  • 98.93 (a)
chicken
(Gallus gallus)
Aves HECTD1 36
  • 86.49 (n)
  • 97.08 (a)
HECTD1 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HECTD1 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19091 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hectd1 36
  • 75.77 (n)
  • 90.79 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1384 36
zebrafish
(Danio rerio)
Actinopterygii hectd1 36
  • 76.18 (n)
  • 89.28 (a)
hectd1 36
hectd1 37
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009511 36
  • 54.35 (n)
  • 59.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5604 36
  • 57.95 (n)
  • 61 (a)
CG5604 37
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hecd-1 36
  • 53.28 (n)
  • 49.67 (a)
hecd-1 37
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UFD4 37
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1003 37
  • 41 (a)
OneToOne
Species with no ortholog for HECTD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HECTD1 Gene

ENSEMBL:
Gene Tree for HECTD1 (if available)
TreeFam:
Gene Tree for HECTD1 (if available)

Paralogs for HECTD1 Gene

Paralogs for HECTD1 Gene

genes like me logo Genes that share paralogs with HECTD1: view

Variants for HECTD1 Gene

Sequence variations from dbSNP and Humsavar for HECTD1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs11152 -- 31,100,211(+) ATATA(A/C)AAAGA utr-variant-3-prime
rs364838 -- 31,116,120(-) TGGCT(A/T)ACAGG intron-variant
rs379586 -- 31,119,089(-) ggagt(C/T)agagt intron-variant
rs386947 -- 31,122,429(-) tgcat(C/T)actgc intron-variant
rs390725 -- 31,118,054(-) gcact(C/T)cagcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HECTD1 Gene

Variant ID Type Subtype PubMed ID
esv33189 CNV Loss 17666407
nsv901581 CNV Gain 21882294
nsv901587 CNV Loss 21882294
nsv832763 CNV Loss 17160897
nsv901588 CNV Loss 21882294
nsv1234 CNV Insertion 18451855

Relevant External Links for HECTD1 Gene

HapMap Linkage Disequilibrium report
HECTD1

Disorders for HECTD1 Gene

No disorders were found for HECTD1 Gene.

No data available for UniProtKB/Swiss-Prot for HECTD1 Gene

Publications for HECTD1 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. (PMID: 12421765) Nakayama M. … Ohara O. (Genome Res. 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain. (PMID: 17550899) Bish R.A. … Myers M.P. (J. Biol. Chem. 2007) 3

Products for HECTD1 Gene

Sources for HECTD1 Gene

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