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Aliases for HECTD1 Gene

Aliases for HECTD1 Gene

  • HECT Domain E3 Ubiquitin Protein Ligase 1 2 3
  • HECT Domain Containing E3 Ubiquitin Protein Ligase 1 2 3 5
  • HECT Domain-Containing Protein 1 3 4
  • E3 Ligase For Inhibin Receptor 3 4
  • EULIR 3 4
  • EC 6.3.2.- 4
  • KIAA1131 4

External Ids for HECTD1 Gene

Previous GeneCards Identifiers for HECTD1 Gene

  • GC14M025356
  • GC14M029559
  • GC14M030639
  • GC14M031569
  • GC14M011686

Summaries for HECTD1 Gene

GeneCards Summary for HECTD1 Gene

HECTD1 (HECT Domain E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include binding and ubiquitin-protein transferase activity. An important paralog of this gene is TRIP12.

UniProtKB/Swiss-Prot for HECTD1 Gene

  • Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECTD1 Gene

Genomics for HECTD1 Gene

Regulatory Elements for HECTD1 Gene

Enhancers for HECTD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HECTD1 on UCSC Golden Path with GeneCards custom track

Promoters for HECTD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HECTD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HECTD1 Gene

Chromosome:
14
Start:
31,100,112 bp from pter
End:
31,208,060 bp from pter
Size:
107,949 bases
Orientation:
Minus strand

Genomic View for HECTD1 Gene

Genes around HECTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HECTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HECTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HECTD1 Gene

Proteins for HECTD1 Gene

  • Protein details for HECTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULT8-HECD1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase HECTD1
    Protein Accession:
    Q9ULT8
    Secondary Accessions:
    • D3DS86
    • Q6P445
    • Q86VJ1
    • Q96F34
    • Q9UFZ7

    Protein attributes for HECTD1 Gene

    Size:
    2610 amino acids
    Molecular mass:
    289384 Da
    Quaternary structure:
    • Interacts with IGSF1.

    Three dimensional structures from OCA and Proteopedia for HECTD1 Gene

neXtProt entry for HECTD1 Gene

Proteomics data for HECTD1 Gene at MOPED

Post-translational modifications for HECTD1 Gene

  • Ubiquitination at Lys 229, Lys 255, Lys 522, Lys 1272, Lys 1287, Lys 1371, Lys 1768, Lys 1919, Lys 2268, and Lys 2605
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HECTD1 Gene

Domains & Families for HECTD1 Gene

Gene Families for HECTD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULT8

UniProtKB/Swiss-Prot:

HECD1_HUMAN :
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Belongs to the UPL family. K-HECT subfamily.
  • Contains 4 ANK repeats.
Domain:
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Contains 1 MIB/HERC2 domain.
Family:
  • Belongs to the UPL family. K-HECT subfamily.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with HECTD1: view

Function for HECTD1 Gene

Molecular function for HECTD1 Gene

UniProtKB/Swiss-Prot Function:
Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity).

Enzyme Numbers (IUBMB) for HECTD1 Gene

Gene Ontology (GO) - Molecular Function for HECTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with HECTD1: view
genes like me logo Genes that share phenotypes with HECTD1: view

Animal Models for HECTD1 Gene

MGI Knock Outs for HECTD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for HECTD1

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HECTD1 Gene

Localization for HECTD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HECTD1 Gene COMPARTMENTS Subcellular localization image for HECTD1 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HECTD1 Gene

Pathways & Interactions for HECTD1 Gene

genes like me logo Genes that share pathways with HECTD1: view

UniProtKB/Swiss-Prot Q9ULT8-HECD1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for HECTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with HECTD1: view

No data available for SIGNOR curated interactions for HECTD1 Gene

Drugs & Compounds for HECTD1 Gene

No Compound Related Data Available

Transcripts for HECTD1 Gene

Unigene Clusters for HECTD1 Gene

HECT domain containing E3 ubiquitin protein ligase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HECTD1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8:
SP9:
SP10:

ExUns: 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for HECTD1 Gene

GeneLoc Exon Structure for
HECTD1
ECgene alternative splicing isoforms for
HECTD1

Expression for HECTD1 Gene

mRNA expression in normal human tissues for HECTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HECTD1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.8).

Protein differential expression in normal tissues from HIPED for HECTD1 Gene

This gene is overexpressed in Cervix (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HECTD1 Gene



SOURCE GeneReport for Unigene cluster for HECTD1 Gene Hs.708017

genes like me logo Genes that share expression patterns with HECTD1: view

Protein tissue co-expression partners for HECTD1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HECTD1 Gene

Orthologs for HECTD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HECTD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HECTD1 35
  • 95.07 (n)
  • 99.62 (a)
HECTD1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HECTD1 35
  • 95.15 (n)
  • 99.46 (a)
HECTD1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hectd1 35
  • 91.85 (n)
  • 98.89 (a)
Hectd1 16
Hectd1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HECTD1 35
  • 99.81 (n)
  • 99.96 (a)
HECTD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hectd1 35
  • 91.71 (n)
  • 98.93 (a)
oppossum
(Monodelphis domestica)
Mammalia HECTD1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HECTD1 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves HECTD1 35
  • 86.49 (n)
  • 97.08 (a)
HECTD1 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HECTD1 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hectd1 35
  • 75.77 (n)
  • 90.79 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19091 35
zebrafish
(Danio rerio)
Actinopterygii hectd1 35
  • 76.18 (n)
  • 89.28 (a)
hectd1 35
hectd1 36
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1384 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009511 35
  • 54.35 (n)
  • 59.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5604 35
  • 57.95 (n)
  • 61 (a)
CG5604 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hecd-1 35
  • 53.28 (n)
  • 49.67 (a)
hecd-1 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UFD4 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1003 36
  • 41 (a)
OneToOne
Species with no ortholog for HECTD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HECTD1 Gene

ENSEMBL:
Gene Tree for HECTD1 (if available)
TreeFam:
Gene Tree for HECTD1 (if available)

Paralogs for HECTD1 Gene

Paralogs for HECTD1 Gene

genes like me logo Genes that share paralogs with HECTD1: view

Variants for HECTD1 Gene

Sequence variations from dbSNP and Humsavar for HECTD1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs11620816 - 31,150,186(+) CCTTG(A/C/G/T)TGCAA nc-transcript-variant, reference, synonymous-codon
rs1315794 - 31,113,174(-) ACAGC(C/T)TCAGT reference, missense
rs11152 -- 31,100,211(+) ATATA(A/C)AAAGA utr-variant-3-prime
rs7140300 -- 31,189,129(+) AAACT(A/G)AAAGA intron-variant
rs364838 -- 31,116,120(-) TGGCT(A/T)ACAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HECTD1 Gene

Variant ID Type Subtype PubMed ID
esv33189 CNV Loss 17666407
nsv901581 CNV Gain 21882294
nsv901587 CNV Loss 21882294
nsv832763 CNV Loss 17160897
nsv901588 CNV Loss 21882294
nsv1234 CNV Insertion 18451855

Variation tolerance for HECTD1 Gene

Residual Variation Intolerance Score: 0.392% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 70.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HECTD1 Gene

Disorders for HECTD1 Gene

Relevant External Links for HECTD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HECTD1

No disorders were found for HECTD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HECTD1 Gene

Publications for HECTD1 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Liganded ERI+ Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation. (PMID: 26389696) Okada M. … Ohta T. (Mol. Endocrinol. 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for HECTD1 Gene

Sources for HECTD1 Gene

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