Aliases for HECA Gene
Aliases for HECA Gene
External Ids for HECA Gene
- HGNC: 21041
- Entrez Gene: 51696
- Ensembl: ENSG00000112406
- OMIM: 607977
- UniProtKB: Q9UBI9
Previous GeneCards Identifiers for HECA Gene
- GC06P139391
- GC06P139436
- GC06P139497
- GC06P137017
Summaries for HECA Gene
-
This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during tracheal development. [provided by RefSeq, Jul 2008]
GeneCards Summary for HECA Gene
HECA (Hdc Homolog, Cell Cycle Regulator) is a Protein Coding gene. Diseases associated with HECA include Lichen Nitidus.
UniProtKB/Swiss-Prot for HECA Gene
-
May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECA Gene
Genomics for HECA Gene
Regulatory Elements for HECA Gene
Enhancers for HECA Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HECA on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HECA gene promoter:
Regulatory Element Products
Genomic Location for HECA Gene
- Chromosome:
- 6
- Start:
- 139,135,112 bp from pter
- End:
- 139,180,809 bp from pter
- Size:
- 45,698 bases
- Orientation:
- Plus strand
Genomic View for HECA Gene
Genes around HECA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q24.1 by Ensembl
- 6q24.1 by Entrez Gene
- 6q24.1 by HGNC
HECA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HECA Gene
Proteins for HECA Gene
-
Protein details for HECA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBI9-HDC_HUMAN
- Recommended name:
- Headcase protein homolog
- Protein Accession:
- Q9UBI9
Protein attributes for HECA Gene
- Size:
- 543 amino acids
- Molecular mass:
- 58837 Da
- Quaternary structure:
- No Data Available
Protein Expression for HECA Gene
Post-translational modifications for HECA Gene
Other Protein References for HECA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HECA
- Novus Biologicals Antibodies for HECA
- Invitrogen Antibodies for HECA
- antibodies-online Antibodies for HECA: See all 18
- GeneTex HECA antibody for HECA
Protein Products
-
OriGene Purified Proteins for HECA
- Search Origene for MassSpec and Protein Over-expression Lysates for HECA
- Origene Custom Protein Services for HECA
- Novus Biologicals proteins for HECA
- antibodies-online Proteins for HECA: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HECA
Assay Products
No data available for DME Specific Peptides for HECA Gene
Domains & Families for HECA Gene
Protein Domains for HECA Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HECA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for HECA Gene
Function for HECA Gene
Molecular function for HECA Gene
- UniProtKB/Swiss-Prot Function:
- May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
Phenotypes for HECA Gene
- GenomeRNAi human phenotypes for HECA:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HECA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HECA gene
- Search ViGene Biosciences for HECA
CRISPR Products
-
OriGene CRISPR knockouts for HECA
-
Santa Cruz Biotechnology (SCBT) CRISPR for HECA
- GenScript: Design CRISPR guide RNA sequences for HECA
miRNA for HECA Gene
- miRTarBase miRNAs that target HECA
-
- hsa-mir-26b-5p (MIRT029329)
- hsa-mir-17-5p (MIRT167837)
- hsa-mir-20a-5p (MIRT167840)
- hsa-mir-93-5p (MIRT167841)
- hsa-mir-106b-5p (MIRT167844)
- hsa-mir-20b-5p (MIRT167847)
- hsa-mir-519d-3p (MIRT167852)
- hsa-mir-4298 (MIRT523313)
- hsa-mir-1302 (MIRT523314)
- hsa-mir-5787 (MIRT523315)
- hsa-mir-6884-5p (MIRT523316)
- hsa-mir-4505 (MIRT523317)
- hsa-mir-485-5p (MIRT523318)
miRNA Products
- Search ViGene Biosciences for HECA
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HECA
- Browse OriGene Inhibitory RNA Products For HECA
-
ViGene Biosciences ready-to-package AAV shRNAs for HECA gene
Cell Line Products
-
Horizon Cell Lines for HECA
-
ViGene Biosciences adenoviral particle packaged cDNA for HECA gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HECA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HECA gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HECA Gene
Localization for HECA Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 19643820 |
| GO:0005737 | cytoplasm | IDA | 19643820 |
| GO:0016020 | membrane | IDA | 19946888 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for HECA Gene
Pathways & Interactions for HECA Gene
No Data Available
Interacting Proteins for HECA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0030323 | respiratory tube development | NAS | 11696983 |
| GO:0045930 | negative regulation of mitotic cell cycle | IMP | 22100912 |
No data available for Pathways by source and SIGNOR curated interactions for HECA Gene
Transcripts for HECA Gene
mRNA/cDNA for HECA Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (128) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HECA Gene
CRISPR Products
-
OriGene CRISPR knockouts for HECA
-
Santa Cruz Biotechnology (SCBT) CRISPR for HECA
- GenScript: Design CRISPR guide RNA sequences for HECA
miRNA Products
- Search ViGene Biosciences for HECA
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HECA
- Browse OriGene Inhibitory RNA Products For HECA
-
ViGene Biosciences ready-to-package AAV shRNAs for HECA gene
Flow Cytometry Products
Expression for HECA Gene
This gene is overexpressed in Fetal Brain (17.1), CD4 Tcells (13.3), Frontal cortex (8.5), Blymphocyte (7.7), CD8 Tcells (7.3), and Placenta (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HECA Gene
NURSA nuclear receptor signaling pathways regulating expression of HECA Gene:
HECASOURCE GeneReport for Unigene cluster for HECA Gene:
Hs.197644mRNA Expression by UniProt/SwissProt for HECA Gene:
Q9UBI9-HDC_HUMAN
Tissue specificity:
Expressed in all tissues examined. Highest levels are in the spleen, thymus, peripheral blood and heart. Lowest in the kidney and pancreas.
Evidence on tissue expression from TISSUES for HECA Gene
- Skin(2.5)
- Blood(2.4)
- Heart(2.3)
- Lymph node(2.2)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for HECA
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HECA Gene
Orthologs for HECA Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HECA 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HECA 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HECA 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Heca 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HECA 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Heca 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | HECA 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HECA 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | heca 34 |
|
||
| Str.19505 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.31027 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | heca 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | hdc 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | cri-1 35 |
|
OneToMany | |
| B0238.9 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for HECA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HECA Gene
No data available for Paralogs for HECA Gene
Variants for HECA Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000040893 | -- | 139,170,304(+) | GGGTA(C/G)TATCA | intron-variant | |
| rs1000054403 | -- | 139,177,312(+) | GATGG(C/G)TAATC | intron-variant, utr-variant-3-prime | |
| rs1000112450 | -- | 139,168,793(+) | ACGTC(C/T)GAGAA | intron-variant | |
| rs1000190101 | -- | 139,164,320(+) | ATTGG(A/G)AGAGT | intron-variant | |
| rs1000240675 | -- | 139,171,375(+) | ATAAA(C/T)AGATA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv32697 | CNV | gain | 17666407 |
| esv3610966 | CNV | gain | 21293372 |
Residual Variation Intolerance Score:
6.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.44;
9.67% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HECA Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HECA
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HECA Gene
Disorders for HECA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lichen nitidus |
|
|
Search HECA in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HECA
No data available for UniProtKB/Swiss-Prot and Genatlas for HECA Gene
Publications for HECA Gene
- Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer. (PMID: 11696983) Makino N. … Horii A. (DNA Seq. 2001) 2 3 4 22 64
- The human homolog of the Drosophila headcase protein slows down cell division of head and neck cancer cells. (PMID: 19643820) Dowejko A. … Reichert T.E. (Carcinogenesis 2009) 2 3 22 64
- The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells. (PMID: 22100912) Dowejko A. … Reichert T.E. (Exp. Cell Res. 2012) 2 3 64
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
- A homologue of the Drosophila headcase protein is a novel tumor marker for early-stage colorectal cancer. (PMID: 16525680) Chien C.C. … Huang C.J. (Oncol. Rep. 2006) 3 22 64
Products for HECA Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HECA
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HECA
- Search Origene for MassSpec and Protein Over-expression Lysates for HECA
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- OriGene qPCR primer pairs for HECA
- OriGene CRISPR knockouts for HECA
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- GenScript: Design CRISPR guide RNA sequences for HECA
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- Novus Biologicals Antibodies for HECA
- Novus Biologicals proteins for HECA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for HECA: See all 18
- Search antibodies-online for kits
- antibodies-online Proteins for HECA: See all 3
- Search antibodies-online for peptides
- GeneTex HECA antibody for HECA
- Search GeneTex for Proteins for HECA
- ViGene Biosciences adenoviral particle packaged cDNA for HECA gene
- ViGene Biosciences lentiviral particle packaged cDNA for HECA gene
- ViGene Biosciences ready-to-package AAV shRNAs for HECA gene
- Search ViGene Biosciences for HECA
- Horizon Cell Lines for HECA
- Cyagen custom Knockout/knockin (KOKI) mouse models for HECA
- VectorBuilder custom plasmid, inducible vectors for HECA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HECA
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HECA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
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- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (97) IUPHAR
- (98) BioGPS
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- (100) COMPARTMENTS
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- (105) antibodies-online
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- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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