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Aliases for HECA Gene

Aliases for HECA Gene

  • Hdc Homolog, Cell Cycle Regulator 2 3 5
  • HHDC 3 4
  • HDC 3 4
  • Headcase Homolog (Drosophila) 2
  • Headcase Protein Homolog 3
  • Headcase Homolog 3
  • DJ225E12.1 3
  • HDCL 3

External Ids for HECA Gene

Previous GeneCards Identifiers for HECA Gene

  • GC06P139391
  • GC06P139436
  • GC06P139497
  • GC06P137017

Summaries for HECA Gene

Entrez Gene Summary for HECA Gene

  • This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during tracheal development. [provided by RefSeq, Jul 2008]

GeneCards Summary for HECA Gene

HECA (Hdc Homolog, Cell Cycle Regulator) is a Protein Coding gene. Diseases associated with HECA include Lichen Nitidus.

UniProtKB/Swiss-Prot for HECA Gene

  • May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECA Gene

Genomics for HECA Gene

Regulatory Elements for HECA Gene

Enhancers for HECA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F139111 1.2 FANTOM5 Ensembl ENCODE 17.7 -21.8 -21784 3.6 PKNOX1 L3MBTL2 HLF CEBPB ELF1 OSR2 GATA3 PBX2 NR2F6 FOXP2 HECA ECT2L LOC102723690 ABRACL REPS1 GC06P139052
GH06F139172 1.1 ENCODE 17.7 +37.8 37832 1.6 CTCF HLF ZNF316 ZNF24 FOS ZBTB33 MAFK EMSY TRIM28 HECA REPS1 ENSG00000231329
GH06F139171 0.2 ENCODE 12.1 +36.3 36339 0.8 ZBTB33 CHAMP1 HECA REPS1 ENSG00000231329
GH06F139175 0.4 ENCODE 12.1 +40.5 40481 0.3 CREB3 ZNF316 MTA2 CEBPA IKZF1 MAFK SPI1 HECA REPS1 ABRACL ENSG00000231329
GH06F139364 1 Ensembl ENCODE 10.8 +229.3 229316 0.5 CTCF ZNF362 ZNF654 TRIM22 ZNF384 REST RAD21 GABPA POLR2H CBX5 ENSG00000231329 LOC102723690 HECA CITED2 LOC100129844
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HECA on UCSC Golden Path with GeneCards custom track

Promoters for HECA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001228736 1488 4001 PKNOX1 ATF1 ARID4B SIN3A ZNF48 BRCA1 GLIS2 ZNF143 ZNF207 KLF7

Genomic Location for HECA Gene

Chromosome:
6
Start:
139,135,112 bp from pter
End:
139,180,809 bp from pter
Size:
45,698 bases
Orientation:
Plus strand

Genomic View for HECA Gene

Genes around HECA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HECA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HECA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HECA Gene

Proteins for HECA Gene

  • Protein details for HECA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBI9-HDC_HUMAN
    Recommended name:
    Headcase protein homolog
    Protein Accession:
    Q9UBI9

    Protein attributes for HECA Gene

    Size:
    543 amino acids
    Molecular mass:
    58837 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HECA Gene

Post-translational modifications for HECA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HECA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HECA Gene

Domains & Families for HECA Gene

Protein Domains for HECA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HECA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HECA: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HECA Gene

Function for HECA Gene

Molecular function for HECA Gene

UniProtKB/Swiss-Prot Function:
May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.

Gene Ontology (GO) - Molecular Function for HECA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with HECA: view
genes like me logo Genes that share phenotypes with HECA: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HECA Gene

Localization for HECA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HECA Gene COMPARTMENTS Subcellular localization image for HECA gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HECA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19643820
GO:0005737 cytoplasm IDA 19643820
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HECA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HECA Gene

Pathways & Interactions for HECA Gene

SuperPathways for HECA Gene

No Data Available

Interacting Proteins for HECA Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356630%0d%0a9606.ENSP00000373873%0d%0a9606.ENSP00000293218%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000356630 Q9UBI9-HDC_HUMAN for HECA Gene via STRING IID

Gene Ontology (GO) - Biological Process for HECA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030323 respiratory tube development NAS 11696983
GO:0045930 negative regulation of mitotic cell cycle IMP 22100912
genes like me logo Genes that share ontologies with HECA: view

No data available for Pathways by source and SIGNOR curated interactions for HECA Gene

Drugs & Compounds for HECA Gene

(1) Drugs for HECA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HECA: view

Transcripts for HECA Gene

mRNA/cDNA for HECA Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(128) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HECA Gene

Headcase homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HECA Gene

No ASD Table

Relevant External Links for HECA Gene

GeneLoc Exon Structure for
HECA
ECgene alternative splicing isoforms for
HECA

Expression for HECA Gene

mRNA expression in normal human tissues for HECA Gene

Protein differential expression in normal tissues from HIPED for HECA Gene

This gene is overexpressed in Fetal Brain (17.1), CD4 Tcells (13.3), Frontal cortex (8.5), Blymphocyte (7.7), CD8 Tcells (7.3), and Placenta (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HECA Gene



Protein tissue co-expression partners for HECA Gene

NURSA nuclear receptor signaling pathways regulating expression of HECA Gene:

HECA

SOURCE GeneReport for Unigene cluster for HECA Gene:

Hs.197644

mRNA Expression by UniProt/SwissProt for HECA Gene:

Q9UBI9-HDC_HUMAN
Tissue specificity: Expressed in all tissues examined. Highest levels are in the spleen, thymus, peripheral blood and heart. Lowest in the kidney and pancreas.
genes like me logo Genes that share expression patterns with HECA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HECA Gene

Orthologs for HECA Gene

This gene was present in the common ancestor of animals.

Orthologs for HECA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HECA 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia HECA 34 35
  • 89.67 (n)
cow
(Bos Taurus)
Mammalia HECA 34 35
  • 89.3 (n)
rat
(Rattus norvegicus)
Mammalia Heca 34
  • 89.08 (n)
oppossum
(Monodelphis domestica)
Mammalia HECA 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Heca 34 16 35
  • 87.91 (n)
chicken
(Gallus gallus)
Aves HECA 34 35
  • 81.39 (n)
lizard
(Anolis carolinensis)
Reptilia HECA 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia heca 34
  • 71.9 (n)
Str.19505 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.31027 34
zebrafish
(Danio rerio)
Actinopterygii heca 34 35
  • 75.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta hdc 35
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cri-1 35
  • 27 (a)
OneToMany
B0238.9 35
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToOne
Species where no ortholog for HECA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HECA Gene

ENSEMBL:
Gene Tree for HECA (if available)
TreeFam:
Gene Tree for HECA (if available)

Paralogs for HECA Gene

No data available for Paralogs for HECA Gene

Variants for HECA Gene

Sequence variations from dbSNP and Humsavar for HECA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10046349 -- 139,159,025(+) CCGAG(A/G)TAGCA intron-variant, downstream-variant-500B
rs10214591 -- 139,175,833(+) AGCCT(C/T)TTGGT intron-variant
rs10214594 -- 139,175,925(+) ATGTT(C/T)GATTA intron-variant
rs10428857 -- 139,143,032(+) ATTCT(C/G)TCTGT intron-variant
rs10440883 -- 139,134,556(+) atttt(A/T)ttttg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HECA Gene

Variant ID Type Subtype PubMed ID
esv32697 CNV gain 17666407
esv3610966 CNV gain 21293372

Variation tolerance for HECA Gene

Residual Variation Intolerance Score: 6.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HECA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HECA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HECA Gene

Disorders for HECA Gene

MalaCards: The human disease database

(1) MalaCards diseases for HECA Gene - From: DISEASES

Disorder Aliases PubMed IDs
lichen nitidus
  • pinkus' disease
- elite association - COSMIC cancer census association via MalaCards
Search HECA in MalaCards View complete list of genes associated with diseases

Relevant External Links for HECA

Genetic Association Database (GAD)
HECA
Human Genome Epidemiology (HuGE) Navigator
HECA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HECA
genes like me logo Genes that share disorders with HECA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HECA Gene

Publications for HECA Gene

  1. Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer. (PMID: 11696983) Makino N. … Horii A. (DNA Seq. 2001) 2 3 4 22 64
  2. The human homolog of the Drosophila headcase protein slows down cell division of head and neck cancer cells. (PMID: 19643820) Dowejko A. … Reichert T.E. (Carcinogenesis 2009) 2 3 22 64
  3. The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells. (PMID: 22100912) Dowejko A. … Reichert T.E. (Exp. Cell Res. 2012) 2 3 64
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  5. A homologue of the Drosophila headcase protein is a novel tumor marker for early-stage colorectal cancer. (PMID: 16525680) Chien C.C. … Huang C.J. (Oncol. Rep. 2006) 3 22 64

Products for HECA Gene

Sources for HECA Gene

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