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Aliases for HECA Gene

Aliases for HECA Gene

  • Hdc Homolog, Cell Cycle Regulator 2 3 5
  • HHDC 3 4
  • HDC 3 4
  • Headcase Homolog (Drosophila) 2
  • Headcase Homolog 3
  • DJ225E12.1 3
  • HDCL 3

External Ids for HECA Gene

Previous GeneCards Identifiers for HECA Gene

  • GC06P139391
  • GC06P139436
  • GC06P139497
  • GC06P137017

Summaries for HECA Gene

Entrez Gene Summary for HECA Gene

  • This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during tracheal development. [provided by RefSeq, Jul 2008]

GeneCards Summary for HECA Gene

HECA (Hdc Homolog, Cell Cycle Regulator) is a Protein Coding gene. Diseases associated with HECA include lichen nitidus. Among its related pathways are Metabolism and Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism.

UniProtKB/Swiss-Prot for HECA Gene

  • May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECA Gene

Genomics for HECA Gene

Regulatory Elements for HECA Gene

Promoters for HECA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HECA on UCSC Golden Path with GeneCards custom track

Genomic Location for HECA Gene

Chromosome:
6
Start:
139,135,112 bp from pter
End:
139,180,809 bp from pter
Size:
45,698 bases
Orientation:
Plus strand

Genomic View for HECA Gene

Genes around HECA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HECA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HECA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HECA Gene

Proteins for HECA Gene

  • Protein details for HECA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBI9-HDC_HUMAN
    Recommended name:
    Headcase protein homolog
    Protein Accession:
    Q9UBI9

    Protein attributes for HECA Gene

    Size:
    543 amino acids
    Molecular mass:
    58837 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HECA Gene

Proteomics data for HECA Gene at MOPED

Post-translational modifications for HECA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HECA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HECA Gene

Domains & Families for HECA Gene

Protein Domains for HECA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HECA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HECA: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HECA Gene

Function for HECA Gene

Molecular function for HECA Gene

UniProtKB/Swiss-Prot Function:
May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.
genes like me logo Genes that share phenotypes with HECA: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HECA Gene

Localization for HECA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HECA Gene COMPARTMENTS Subcellular localization image for HECA gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HECA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19643820
genes like me logo Genes that share ontologies with HECA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HECA Gene

Pathways & Interactions for HECA Gene

genes like me logo Genes that share pathways with HECA: view

Interacting Proteins for HECA Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356630%0d%0a9606.ENSP00000293218%0d%0a9606.ENSP00000373873%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000356630 Q9UBI9-HDC_HUMAN for HECA Gene via STRING I2D

Gene Ontology (GO) - Biological Process for HECA Gene

None

No data available for SIGNOR curated interactions for HECA Gene

Drugs & Compounds for HECA Gene

(1) Drugs for HECA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HECA: view

Transcripts for HECA Gene

mRNA/cDNA for HECA Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(128) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HECA Gene

Headcase homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HECA Gene

No ASD Table

Relevant External Links for HECA Gene

GeneLoc Exon Structure for
HECA
ECgene alternative splicing isoforms for
HECA

Expression for HECA Gene

mRNA expression in normal human tissues for HECA Gene

Protein differential expression in normal tissues from HIPED for HECA Gene

This gene is overexpressed in Fetal Brain (17.1), CD4 Tcells (13.3), Frontal cortex (8.5), Blymphocyte (7.7), CD8 Tcells (7.3), and Placenta (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HECA Gene



SOURCE GeneReport for Unigene cluster for HECA Gene Hs.197644

mRNA Expression by UniProt/SwissProt for HECA Gene

Q9UBI9-HDC_HUMAN
Tissue specificity: Expressed in all tissues examined. Highest levels are in the spleen, thymus, peripheral blood and heart. Lowest in the kidney and pancreas.
genes like me logo Genes that share expression patterns with HECA: view

Protein tissue co-expression partners for HECA Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HECA Gene

Orthologs for HECA Gene

This gene was present in the common ancestor of animals.

Orthologs for HECA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HECA 35
  • 89.3 (n)
  • 95.38 (a)
HECA 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HECA 35
  • 89.67 (n)
  • 96.07 (a)
HECA 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Heca 35
  • 87.91 (n)
  • 95.21 (a)
Heca 16
Heca 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HECA 35
  • 99.45 (n)
  • 99.63 (a)
HECA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Heca 35
  • 89.08 (n)
  • 96.87 (a)
oppossum
(Monodelphis domestica)
Mammalia HECA 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves HECA 35
  • 81.39 (n)
  • 92.09 (a)
HECA 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HECA 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia heca 35
  • 71.9 (n)
  • 83.04 (a)
Str.19505 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.31027 35
zebrafish
(Danio rerio)
Actinopterygii heca 35
  • 75.41 (n)
  • 80.89 (a)
heca 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta hdc 36
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0238.9 36
  • 18 (a)
OneToMany
cri-1 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for HECA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HECA Gene

ENSEMBL:
Gene Tree for HECA (if available)
TreeFam:
Gene Tree for HECA (if available)

Paralogs for HECA Gene

No data available for Paralogs for HECA Gene

Variants for HECA Gene

Sequence variations from dbSNP and Humsavar for HECA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs961782 -- 139,147,385(+) CTTTA(A/G)GAGGC intron-variant
rs1406818 -- 139,155,847(+) TTCAA(C/T)TACTC intron-variant
rs1406819 -- 139,155,901(+) TTTCA(A/G)CAAGC intron-variant
rs2149045 -- 139,156,903(-) CCCCT(C/G)TCCTG intron-variant
rs2498675 -- 139,137,173(+) CTGGC(G/T)TTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HECA Gene

Variant ID Type Subtype PubMed ID
esv32697 CNV Gain 17666407

Variation tolerance for HECA Gene

Residual Variation Intolerance Score: 6.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HECA Gene

HapMap Linkage Disequilibrium report
HECA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HECA Gene

Disorders for HECA Gene

MalaCards: The human disease database

(1) MalaCards diseases for HECA Gene - From: DISEASES

Disorder Aliases PubMed IDs
lichen nitidus
  • pinkus' disease
- elite association - COSMIC cancer census association via MalaCards
Search HECA in MalaCards View complete list of genes associated with diseases

Relevant External Links for HECA

Genetic Association Database (GAD)
HECA
Human Genome Epidemiology (HuGE) Navigator
HECA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HECA
genes like me logo Genes that share disorders with HECA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HECA Gene

Publications for HECA Gene

  1. Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer. (PMID: 11696983) Makino N. … Horii A. (DNA Seq. 2001) 2 3 4 23 67
  2. The human homolog of the Drosophila headcase protein slows down cell division of head and neck cancer cells. (PMID: 19643820) Dowejko A. … Reichert T.E. (Carcinogenesis 2009) 2 3 23
  3. The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells. (PMID: 22100912) Dowejko A. … Reichert T.E. (Exp. Cell Res. 2012) 2 3
  4. A homologue of the Drosophila headcase protein is a novel tumor marker for early-stage colorectal cancer. (PMID: 16525680) Chien C.C. … Huang C.J. (Oncol. Rep. 2006) 3 23
  5. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3

Products for HECA Gene

Sources for HECA Gene

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