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Aliases for HEBP2 Gene

Aliases for HEBP2 Gene

  • Heme Binding Protein 2 2 3
  • C6orf34 3 4 6
  • SOUL 3 4 6
  • Placental Protein 23 3 4
  • PP23 3 4
  • Chromosome 6 Open Reading Frame 34 2
  • Heme-Binding Protein 2 3
  • Protein SOUL 4
  • C6ORF34B 3

External Ids for HEBP2 Gene

Previous HGNC Symbols for HEBP2 Gene

  • C6orf34

Previous GeneCards Identifiers for HEBP2 Gene

  • GC06P138348
  • GC06P138572
  • GC06P138705
  • GC06P138767
  • GC06P136286
  • GC06P138724

Summaries for HEBP2 Gene

GeneCards Summary for HEBP2 Gene

HEBP2 (Heme Binding Protein 2) is a Protein Coding gene. An important paralog of this gene is HEBP1.

UniProtKB/Swiss-Prot for HEBP2 Gene

  • Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.

Gene Wiki entry for HEBP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEBP2 Gene

Genomics for HEBP2 Gene

Regulatory Elements for HEBP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HEBP2 Gene

138,403,531 bp from pter
138,422,197 bp from pter
18,667 bases
Plus strand

Genomic View for HEBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HEBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEBP2 Gene

Proteins for HEBP2 Gene

  • Protein details for HEBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heme-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • Q96P57

    Protein attributes for HEBP2 Gene

    205 amino acids
    Molecular mass:
    22875 Da
    Quaternary structure:
    • Monomer. Interacts with LRPPRC. May interact with BCL2L1. An interaction with BCL2L1 was observed using a peptide, but not with the full-length protein. The full-length protein would have to undergo a major conformation change for the interaction to occur.

    Three dimensional structures from OCA and Proteopedia for HEBP2 Gene

    Alternative splice isoforms for HEBP2 Gene


neXtProt entry for HEBP2 Gene

Proteomics data for HEBP2 Gene at MOPED

Post-translational modifications for HEBP2 Gene

  • Ubiquitination at Lys172 and Lys184
  • Modification sites at PhosphoSitePlus

Other Protein References for HEBP2 Gene

No data available for DME Specific Peptides for HEBP2 Gene

Domains for HEBP2 Gene

Protein Domains for HEBP2 Gene

Suggested Antigen Peptide Sequences for HEBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y5Z4
  • Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel.
  • Belongs to the HEBP family.
genes like me logo Genes that share domains with HEBP2: view

No data available for Gene Families for HEBP2 Gene

Function for HEBP2 Gene

Molecular function for HEBP2 Gene

UniProtKB/Swiss-Prot Function: Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.

Gene Ontology (GO) - Molecular Function for HEBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with HEBP2: view

Phenotypes for HEBP2 Gene

GenomeRNAi human phenotypes for HEBP2:
genes like me logo Genes that share phenotypes with HEBP2: view

Animal Model Products

CRISPR Products

miRNA for HEBP2 Gene

miRTarBase miRNAs that target HEBP2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEBP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HEBP2 Gene

Localization for HEBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEBP2 Gene

Cytoplasm. Mitochondrion. Note=Mainly localized to the cytoplasm with a much lower abundance in the mitochondrion.

Subcellular locations from

Jensen Localization Image for HEBP2 Gene COMPARTMENTS Subcellular localization image for HEBP2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HEBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17098234
GO:0005739 mitochondrion IDA 17098234
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with HEBP2: view

Pathways for HEBP2 Gene

SuperPathways for HEBP2 Gene

No Data Available

Interacting Proteins for HEBP2 Gene

Selected Interacting proteins: Q9Y5Z4-HEBP2_HUMAN for HEBP2 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for HEBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010917 negative regulation of mitochondrial membrane potential IMP 17098234
GO:0010940 positive regulation of necrotic cell death IMP 17098234
GO:0035794 positive regulation of mitochondrial membrane permeability IMP 17098234
GO:1901031 NOT regulation of response to reactive oxygen species IMP 17098234
genes like me logo Genes that share ontologies with HEBP2: view

No data available for Pathways by source for HEBP2 Gene

Compounds for HEBP2 Gene

(1) HMDB Compounds for HEBP2 Gene

Compound Synonyms Cas Number PubMed IDs
  • (protoporphyrinato)iron
genes like me logo Genes that share compounds with HEBP2: view

Transcripts for HEBP2 Gene

mRNA/cDNA for HEBP2 Gene

Unigene Clusters for HEBP2 Gene

Heme binding protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEBP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HEBP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2: -

Relevant External Links for HEBP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HEBP2 Gene

mRNA expression in normal human tissues for HEBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HEBP2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HEBP2 Gene

SOURCE GeneReport for Unigene cluster for HEBP2 Gene Hs.486589

mRNA Expression by UniProt/SwissProt for HEBP2 Gene

Tissue specificity: Detected in placenta.
genes like me logo Genes that share expressions with HEBP2: view

In Situ Assay Products

Orthologs for HEBP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HEBP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HEBP2 35
  • 99.51 (n)
  • 99.02 (a)
HEBP2 36
  • 99 (a)
(Bos Taurus)
Mammalia HEBP2 35
  • 88.94 (n)
  • 88.29 (a)
HEBP2 36
  • 88 (a)
(Canis familiaris)
Mammalia HEBP2 35
  • 87.33 (n)
  • 84 (a)
HEBP2 36
  • 82 (a)
(Mus musculus)
Mammalia Hebp2 35
  • 84.72 (n)
  • 83.9 (a)
Hebp2 16
Hebp2 36
  • 84 (a)
(Monodelphis domestica)
Mammalia HEBP2 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia HEBP2 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Hebp2 35
  • 84.07 (n)
  • 82.27 (a)
(Gallus gallus)
Aves HEBP2 35
  • 58.04 (n)
  • 48.82 (a)
HEBP2 36
  • 44 (a)
(Anolis carolinensis)
Reptilia HEBP2 36
  • 57 (a)
(Danio rerio)
Actinopterygii hebp2 35
  • 54.61 (n)
  • 50.28 (a)
hebp2 36
  • 47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G17100 35
  • 48.6 (n)
  • 46.45 (a)
(Oryza sativa)
Liliopsida Os01g0210500 35
  • 46.2 (n)
  • 39.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
CSA.10114 36
  • 27 (a)
CSA.2043 36
  • 37 (a)
Species with no ortholog for HEBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HEBP2 Gene

Gene Tree for HEBP2 (if available)
Gene Tree for HEBP2 (if available)

Paralogs for HEBP2 Gene

Paralogs for HEBP2 Gene Pseudogenes for HEBP2 Gene

genes like me logo Genes that share paralogs with HEBP2: view

Variants for HEBP2 Gene

Sequence variations from dbSNP and Humsavar for HEBP2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs13778 -- 138,413,175(+) CTTCT(A/G)TTGAG utr-variant-3-prime
rs14812 - 138,413,032(+) TAATG(A/C)AGTGT reference, missense
rs1053656 -- 138,413,078(+) GAATG(A/G)GAAAA reference, stop-lost
rs1053657 -- 138,413,285(+) TAAAT(C/T)GGTCA utr-variant-3-prime
rs1132915 -- 138,404,559(+) TGGAG(A/G)CGCCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HEBP2 Gene

Variant ID Type Subtype PubMed ID
esv2752090 CNV Gain 17911159

Relevant External Links for HEBP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEBP2 Gene

Disorders for HEBP2 Gene

No disorders were found for HEBP2 Gene.

No data available for UniProtKB/Swiss-Prot for HEBP2 Gene

Publications for HEBP2 Gene

  1. Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches. (PMID: 10640688) Zylka M.J. … Reppert S.M. (Brain Res. Mol. Brain Res. 1999) 2 3 4
  2. Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL. (PMID: 17098234) Szigeti A. … Gallyas F. Jr. (FEBS Lett. 2006) 2 3 4
  3. Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity. (PMID: 11827465) Liu L. … McKeehan W.L. (Genomics 2002) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HEBP2 Gene

Sources for HEBP2 Gene

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