Aliases for HEBP2 Gene
Aliases for HEBP2 Gene
External Ids for HEBP2 Gene
- HGNC: 15716
- Entrez Gene: 23593
- Ensembl: ENSG00000051620
- OMIM: 605825
- UniProtKB: Q9Y5Z4
Previous HGNC Symbols for HEBP2 Gene
- C6orf34
Previous GeneCards Identifiers for HEBP2 Gene
- GC06P138348
- GC06P138572
- GC06P138705
- GC06P138767
- GC06P136286
- GC06P138724
Summaries for HEBP2 Gene
-
The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016]
GeneCards Summary for HEBP2 Gene
HEBP2 (Heme Binding Protein 2) is a Protein Coding gene. Among its related pathways are Innate Immune System. An important paralog of this gene is HEBP1.
UniProtKB/Swiss-Prot for HEBP2 Gene
-
Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEBP2 Gene
Genomics for HEBP2 Gene
Regulatory Elements for HEBP2 Gene
Enhancers for HEBP2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HEBP2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HEBP2 Gene
- Chromosome:
- 6
- Start:
- 138,403,531 bp from pter
- End:
- 138,422,197 bp from pter
- Size:
- 18,667 bases
- Orientation:
- Plus strand
Genomic View for HEBP2 Gene
Genes around HEBP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q24.1 by Ensembl
- 6q24.1 by Entrez Gene
- 6q24.1 by HGNC
HEBP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HEBP2 Gene
Proteins for HEBP2 Gene
-
Protein details for HEBP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y5Z4-HEBP2_HUMAN
- Recommended name:
- Heme-binding protein 2
- Protein Accession:
- Q9Y5Z4
- Q96P57
Protein attributes for HEBP2 Gene
- Size:
- 205 amino acids
- Molecular mass:
- 22875 Da
- Quaternary structure:
-
- Monomer. Interacts with LRPPRC (PubMed:11827465). May interact with BCL2L1; an interaction with BCL2L1 was observed using a peptide, but not with the full-length protein (PubMed:21639858). The full-length protein would have to undergo a major conformation change for the interaction to occur (PubMed:21639858). Interacts with PDCD6 (PubMed:27784779).
Three dimensional structures from OCA and Proteopedia for HEBP2 Gene
Protein Expression for HEBP2 Gene
Post-translational modifications for HEBP2 Gene
Other Protein References for HEBP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HEBP2
- Novus Biologicals Antibodies for HEBP2
-
Abcam antibodies for HEBP2
- Invitrogen Antibodies for HEBP2
- antibodies-online Antibodies for HEBP2: See all 35
- Search GeneTex for Antibodies for HEBP2
Protein Products
-
OriGene Purified Proteins for HEBP2
- Search Origene for MassSpec and Protein Over-expression Lysates for HEBP2
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- antibodies-online Proteins for HEBP2: See all 8
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- Search GeneTex for Proteins for HEBP2
-
Abcam proteins for HEBP2
Assay Products
No data available for DME Specific Peptides for HEBP2 Gene
Domains & Families for HEBP2 Gene
Protein Domains for HEBP2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HEBP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y5Z4UniProtKB/Swiss-Prot:
HEBP2_HUMAN :- Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel.
- Belongs to the HEBP family.
- Domain:
-
- Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel.
- Family:
-
- Belongs to the HEBP family.
No data available for Gene Families for HEBP2 Gene
Function for HEBP2 Gene
Molecular function for HEBP2 Gene
- UniProtKB/Swiss-Prot Function:
- Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for HEBP2 Gene
- GenomeRNAi human phenotypes for HEBP2:
Animal Model Products
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ViGene Biosciences lentiviral particle packaged cDNA for HEBP2 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for HEBP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEBP2
- GenScript: Design CRISPR guide RNA sequences for HEBP2
miRNA for HEBP2 Gene
- miRTarBase miRNAs that target HEBP2
-
- hsa-mir-124-3p (MIRT002643)
- hsa-mir-5698 (MIRT607482)
- hsa-mir-6805-3p (MIRT607483)
- hsa-mir-5691 (MIRT607484)
- hsa-mir-143-5p (MIRT607485)
- hsa-mir-6879-3p (MIRT607486)
- hsa-mir-4430 (MIRT607487)
- hsa-mir-3652 (MIRT607488)
- hsa-mir-3622b-5p (MIRT607489)
- hsa-mir-122-5p (MIRT607490)
- hsa-mir-504-3p (MIRT607491)
- hsa-mir-3135b (MIRT607492)
- hsa-mir-3194-3p (MIRT607493)
- hsa-mir-6499-3p (MIRT607494)
- hsa-mir-4772-5p (MIRT607495)
- hsa-mir-383-5p (MIRT607496)
- hsa-mir-215-3p (MIRT607497)
- hsa-mir-6773-3p (MIRT607498)
- hsa-mir-5693 (MIRT607499)
- hsa-mir-500b-3p (MIRT607500)
- hsa-mir-1260a (MIRT642168)
- hsa-mir-4314 (MIRT642169)
- hsa-mir-4486 (MIRT642170)
- hsa-mir-6860 (MIRT642171)
- hsa-mir-612 (MIRT642172)
- hsa-mir-5189-5p (MIRT642173)
- hsa-mir-3187-5p (MIRT642174)
- hsa-mir-1285-3p (MIRT642175)
- hsa-mir-532-3p (MIRT642176)
- hsa-mir-1224-3p (MIRT642177)
- hsa-mir-6877-3p (MIRT642178)
- hsa-mir-6819-3p (MIRT642179)
- hsa-mir-5189-3p (MIRT715671)
- hsa-mir-6872-3p (MIRT715672)
- hsa-mir-6884-3p (MIRT715673)
- hsa-mir-1972 (MIRT715674)
- hsa-mir-622 (MIRT715675)
- hsa-mir-15a-3p (MIRT715676)
- hsa-mir-543 (MIRT715677)
miRNA Products
- Search ViGene Biosciences for HEBP2
Inhibitory RNA Products
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-
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-
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Cell Line Products
-
Horizon Cell Lines for HEBP2
-
ViGene Biosciences adenoviral particle packaged cDNA for HEBP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HEBP2 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HEBP2 Gene
Localization for HEBP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HEBP2 Gene
- Cytoplasm. Mitochondrion. Note=Mainly localized to the cytoplasm with a much lower abundance in the mitochondrion. {ECO:0000269 PubMed:17098234}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| lysosome | 4 |
| cytosol | 3 |
| nucleus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 17098234 |
| GO:0005739 | mitochondrion | IEA,IDA | 17098234 |
| GO:0035578 | azurophil granule lumen | TAS | -- |
| GO:0070062 | extracellular exosome | IDA | 19056867 |
Pathways & Interactions for HEBP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
Pathways by source for HEBP2 Gene
3 Reactome pathways for HEBP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010917 | negative regulation of mitochondrial membrane potential | IMP | 17098234 |
| GO:0010940 | positive regulation of necrotic cell death | IMP | 17098234 |
| GO:0035794 | positive regulation of mitochondrial membrane permeability | IMP | 17098234 |
| GO:0043312 | neutrophil degranulation | TAS | -- |
| GO:1901031 | NOT regulation of response to reactive oxygen species | IMP | 17098234 |
No data available for SIGNOR curated interactions for HEBP2 Gene
Drugs & Compounds for HEBP2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| heme | Pharma | Agonist | 0 |
Transcripts for HEBP2 Gene
mRNA/cDNA for HEBP2 Gene
- (4) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (188) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HEBP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HEBP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEBP2
- GenScript: Design CRISPR guide RNA sequences for HEBP2
miRNA Products
- Search ViGene Biosciences for HEBP2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HEBP2
- Browse OriGene Inhibitory RNA Products For HEBP2
-
ViGene Biosciences ready-to-package AAV shRNAs for HEBP2 gene
Clone Products
-
OriGene ORF clones in human for HEBP2
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Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | ||||||||||||||
| SP3: |
Expression for HEBP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Hippocampus
- Cerebellum
- Lateral Ventricle
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Neural Tube (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Pancreas (Endocrine System)
- Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for HEBP2 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x4.1).
This gene is overexpressed in Liver, secretome (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HEBP2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HEBP2 Gene:
HEBP2SOURCE GeneReport for Unigene cluster for HEBP2 Gene:
Hs.486589mRNA Expression by UniProt/SwissProt for HEBP2 Gene:
Q9Y5Z4-HEBP2_HUMAN
Tissue specificity:
Detected in placenta.
Evidence on tissue expression from TISSUES for HEBP2 Gene
- Liver(4.5)
- Eye(4.2)
- Heart(2.6)
- Muscle(2.5)
- Stomach(2.2)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for HEBP2
-
OriGene qPCR primer pairs and template standards for HEBP2
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HEBP2 Gene
Orthologs for HEBP2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HEBP2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HEBP2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HEBP2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hebp2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hebp2 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HEBP2 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HEBP2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HEBP2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HEBP2 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | hebp2 34 35 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G17100 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0210500 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2043 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| CSA.10114 35 |
|
ManyToMany |
- Species where no ortholog for HEBP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HEBP2 Gene
Pseudogenes.org Pseudogenes for HEBP2 Gene
Variants for HEBP2 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs193920889 | Uncertain significance | 138,405,167(+) | CCGAC(A/G)CTATG | nc-transcript-variant, reference, missense | |
| rs1000101098 | -- | 138,406,375(+) | ATATA(A/G)GACAC | intron-variant | |
| rs1000138453 | -- | 138,415,358(+) | TAGGT(A/G)GCACA | nc-transcript-variant | |
| rs1000475861 | -- | 138,414,195(+) | AGTAC(C/G)CAGAA | intron-variant | |
| rs1000490871 | -- | 138,415,587(+) | AACTA(A/G)GTGTG | nc-transcript-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2752090 | CNV | gain | 17911159 |
Residual Variation Intolerance Score:
87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.27;
25.43% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HEBP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HEBP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEBP2 Gene
Disorders for HEBP2 Gene
Relevant External Links for HEBP2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HEBP2
No disorders were found for HEBP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HEBP2 Gene
Publications for HEBP2 Gene
- Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL. (PMID: 17098234) Szigeti A. … Gallyas F. Jr. (FEBS Lett. 2006) 2 3 4 64
- Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches. (PMID: 10640688) Zylka M.J. … Reppert S.M. (Brain Res. Mol. Brain Res. 1999) 2 3 4 64
- Structural and functional study of apoptosis-linked gene-2.Heme- binding protein 2 interactions in HIV-1 production. (PMID: 27784779) Ma J. … Liu X. (J. Biol. Chem. 2016) 3 4 64
- Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. (PMID: 21639858) Ambrosi E. … Monaco H.L. (Biochem. J. 2011) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for HEBP2 Gene
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HEBP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer