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Aliases for HEBP2 Gene

Aliases for HEBP2 Gene

  • Heme Binding Protein 2 2 3 5
  • Placental Protein 23 3 4
  • C6orf34 3 4
  • PP23 3 4
  • SOUL 3 4
  • Chromosome 6 Open Reading Frame 34 2
  • Protein SOUL 4
  • C6ORF34B 3

External Ids for HEBP2 Gene

Previous HGNC Symbols for HEBP2 Gene

  • C6orf34

Previous GeneCards Identifiers for HEBP2 Gene

  • GC06P138348
  • GC06P138572
  • GC06P138705
  • GC06P138767
  • GC06P136286
  • GC06P138724

Summaries for HEBP2 Gene

GeneCards Summary for HEBP2 Gene

HEBP2 (Heme Binding Protein 2) is a Protein Coding gene. An important paralog of this gene is HEBP1.

UniProtKB/Swiss-Prot for HEBP2 Gene

  • Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.

Gene Wiki entry for HEBP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEBP2 Gene

Genomics for HEBP2 Gene

Regulatory Elements for HEBP2 Gene

Enhancers for HEBP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HEBP2 on UCSC Golden Path with GeneCards custom track

Promoters for HEBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HEBP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HEBP2 Gene

Chromosome:
6
Start:
138,403,531 bp from pter
End:
138,422,197 bp from pter
Size:
18,667 bases
Orientation:
Plus strand

Genomic View for HEBP2 Gene

Genes around HEBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HEBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HEBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEBP2 Gene

Proteins for HEBP2 Gene

  • Protein details for HEBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Z4-HEBP2_HUMAN
    Recommended name:
    Heme-binding protein 2
    Protein Accession:
    Q9Y5Z4
    Secondary Accessions:
    • Q96P57

    Protein attributes for HEBP2 Gene

    Size:
    205 amino acids
    Molecular mass:
    22875 Da
    Quaternary structure:
    • Monomer. Interacts with LRPPRC. May interact with BCL2L1. An interaction with BCL2L1 was observed using a peptide, but not with the full-length protein. The full-length protein would have to undergo a major conformation change for the interaction to occur.

    Three dimensional structures from OCA and Proteopedia for HEBP2 Gene

    Alternative splice isoforms for HEBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HEBP2 Gene

Proteomics data for HEBP2 Gene at MOPED

Post-translational modifications for HEBP2 Gene

  • Ubiquitination at Lys 172
  • Modification sites at PhosphoSitePlus

Other Protein References for HEBP2 Gene

No data available for DME Specific Peptides for HEBP2 Gene

Domains & Families for HEBP2 Gene

Protein Domains for HEBP2 Gene

Suggested Antigen Peptide Sequences for HEBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5Z4

UniProtKB/Swiss-Prot:

HEBP2_HUMAN :
  • Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel.
  • Belongs to the HEBP family.
Domain:
  • Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel.
Family:
  • Belongs to the HEBP family.
genes like me logo Genes that share domains with HEBP2: view

No data available for Gene Families for HEBP2 Gene

Function for HEBP2 Gene

Molecular function for HEBP2 Gene

UniProtKB/Swiss-Prot Function:
Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.
genes like me logo Genes that share phenotypes with HEBP2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HEBP2 Gene

Localization for HEBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEBP2 Gene

Cytoplasm. Mitochondrion. Note=Mainly localized to the cytoplasm with a much lower abundance in the mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEBP2 Gene COMPARTMENTS Subcellular localization image for HEBP2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for HEBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 17098234
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with HEBP2: view

Pathways & Interactions for HEBP2 Gene

SuperPathways for HEBP2 Gene

No Data Available

Interacting Proteins for HEBP2 Gene

Selected Interacting proteins: Q9Y5Z4-HEBP2_HUMAN for HEBP2 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for HEBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010917 negative regulation of mitochondrial membrane potential IMP 17098234
GO:0010940 positive regulation of necrotic cell death IMP 17098234
genes like me logo Genes that share ontologies with HEBP2: view

No data available for Pathways by source and SIGNOR curated interactions for HEBP2 Gene

Drugs & Compounds for HEBP2 Gene

(1) Drugs for HEBP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0
genes like me logo Genes that share compounds with HEBP2: view

Transcripts for HEBP2 Gene

Unigene Clusters for HEBP2 Gene

Heme binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HEBP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2: -
SP3:

Relevant External Links for HEBP2 Gene

GeneLoc Exon Structure for
HEBP2
ECgene alternative splicing isoforms for
HEBP2

Expression for HEBP2 Gene

mRNA expression in normal human tissues for HEBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HEBP2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.1).

Protein differential expression in normal tissues from HIPED for HEBP2 Gene

This gene is overexpressed in Liver, secretome (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for HEBP2 Gene



SOURCE GeneReport for Unigene cluster for HEBP2 Gene Hs.486589

mRNA Expression by UniProt/SwissProt for HEBP2 Gene

Q9Y5Z4-HEBP2_HUMAN
Tissue specificity: Detected in placenta.
genes like me logo Genes that share expression patterns with HEBP2: view

Protein tissue co-expression partners for HEBP2 Gene

- Elite partner

Primer Products

Orthologs for HEBP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HEBP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HEBP2 35
  • 88.94 (n)
  • 88.29 (a)
HEBP2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HEBP2 35
  • 87.33 (n)
  • 84 (a)
HEBP2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hebp2 35
  • 84.72 (n)
  • 83.9 (a)
Hebp2 16
Hebp2 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HEBP2 35
  • 99.51 (n)
  • 99.02 (a)
HEBP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hebp2 35
  • 84.07 (n)
  • 82.27 (a)
oppossum
(Monodelphis domestica)
Mammalia HEBP2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HEBP2 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves HEBP2 35
  • 58.04 (n)
  • 48.82 (a)
HEBP2 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HEBP2 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hebp2 35
  • 54.61 (n)
  • 50.28 (a)
hebp2 36
  • 47 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G17100 35
  • 48.6 (n)
  • 46.45 (a)
rice
(Oryza sativa)
Liliopsida Os01g0210500 35
  • 46.2 (n)
  • 39.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
ManyToMany
CSA.10114 36
  • 27 (a)
ManyToMany
CSA.2043 36
  • 37 (a)
ManyToMany
Species with no ortholog for HEBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HEBP2 Gene

ENSEMBL:
Gene Tree for HEBP2 (if available)
TreeFam:
Gene Tree for HEBP2 (if available)

Paralogs for HEBP2 Gene

Paralogs for HEBP2 Gene

Pseudogenes.org Pseudogenes for HEBP2 Gene

genes like me logo Genes that share paralogs with HEBP2: view

Variants for HEBP2 Gene

Sequence variations from dbSNP and Humsavar for HEBP2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3734303 - 138,406,151(+) TGTAC(A/C/G)GTAAG nc-transcript-variant, reference, missense
rs14812 - 138,413,032(+) TAATG(A/C)AGTGT nc-transcript-variant, reference, missense
rs1053656 -- 138,413,078(+) GAATG(A/G)GAAAA nc-transcript-variant, reference, stop-lost
rs1053657 -- 138,413,285(+) TAAAT(C/T)GGTCA intron-variant, utr-variant-3-prime
rs1132915 -- 138,404,559(+) TGGAG(A/G)CGCCG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HEBP2 Gene

Variant ID Type Subtype PubMed ID
esv2752090 CNV Gain 17911159

Variation tolerance for HEBP2 Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HEBP2 Gene

Disorders for HEBP2 Gene

Relevant External Links for HEBP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HEBP2

No disorders were found for HEBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HEBP2 Gene

Publications for HEBP2 Gene

  1. Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL. (PMID: 17098234) Szigeti A. … Gallyas F. Jr. (FEBS Lett. 2006) 2 3 4 67
  2. Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches. (PMID: 10640688) Zylka M.J. … Reppert S.M. (Brain Res. Mol. Brain Res. 1999) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The presence of HIV-1 Tat protein second exon delays fas protein-mediated apoptosis in CD4+ T lymphocytes: a potential mechanism for persistent viral production. (PMID: 23364796) LA^pez-Huertas M.R. … Coiras M. (J. Biol. Chem. 2013) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for HEBP2 Gene

Sources for HEBP2 Gene

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