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HEBP2 Gene

protein-coding   GIFtS: 49
GCID: GC06P138724

Heme Binding Protein 2

(Previous name: chromosome 6 open reading frame 34)
(Previous symbol: C6orf34)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heme Binding Protein 21 2     Chromosome 6 Open Reading Frame 341
C6orf341 2 3 5     C6ORF34B2
SOUL2 3 5     Heme-Binding Protein 22
Placental Protein 232 3     Protein SOUL3
PP232 3     

External Ids:    HGNC: 157161   Entrez Gene: 235932   Ensembl: ENSG000000516207   OMIM: 6058255   UniProtKB: Q9Y5Z43   

Export aliases for HEBP2 gene to outside databases

Previous GC identifers: GC06P138348 GC06P138572 GC06P138705 GC06P138767 GC06P136286


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HEBP2 Gene:
HEBP2 (heme binding protein 2) is a protein-coding gene. Diseases associated with HEBP2 include tonsillitis, and thyroiditis. An important paralog of this gene is HEBP1.

UniProtKB/Swiss-Prot: HEBP2_HUMAN, Q9Y5Z4
Function: Can promote mitochondrial permeability transition and facilitate necrotic cell death under different
types of stress conditions. Does not bind hemin

Gene Wiki entry for HEBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HEBP2 gene promoter:
         GR   Pax-5   Pax-2   Pax-2a   HEN1   CREB   IRF-2   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHEBP2 promoter sequence
   Search Chromatin IP Primers for HEBP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HEBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24   Ensembl cytogenetic band:  6q23.3   HGNC cytogenetic band: 6q24

HEBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HEBP2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P138724:  view genomic region     (about GC identifiers)

Start:
138,724,668 bp from pter      End:
138,743,334 bp from pter
Size:
18,667 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HEBP2_HUMAN, Q9Y5Z4 (See protein sequence)
Recommended Name: Heme-binding protein 2  
Size: 205 amino acids; 22875 Da
Subunit: Monomer. Interacts with LRPPRC. May interact with BCL2L1. An interaction with BCL2L1 was observed using a
peptide, but not with the full-length protein. The full-length protein would have to undergo a major conformation
change for the interaction to occur
Caution: Has been described as heme-binding protein in mouse, but His-42, a residue essential for heme binding in
mouse, is not conserved in all orthologs, or in the heme-binding family member HEBP1
5 PDB 3D structures from and Proteopedia for HEBP2:
3R85 (3D)        3R8J (3D)        3R8K (3D)        4AYZ (3D)        4B0Y (3D)    
Secondary accessions: Q96P57
Alternative splicing: 2 isoforms:  Q9Y5Z4-1   Q9Y5Z4-2   

Explore the universe of human proteins at neXtProt for HEBP2: NX_Q9Y5Z4

Explore proteomics data for HEBP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys172, Lys184
  • Modification sites at PhosphoSitePlus

  • See HEBP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055135.1  
    ENSEMBL proteins: 
     ENSP00000392101   ENSP00000475750   ENSP00000356670   ENSP00000395958  

    HEBP2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for HEBP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011256 Reg_factor_effector_dom
     IPR006917 SOUL_haem-bd

    Graphical View of Domain Structure for InterPro Entry Q9Y5Z4

    ProtoNet protein and cluster: Q9Y5Z4

    UniProtKB/Swiss-Prot: HEBP2_HUMAN, Q9Y5Z4
    Domain: Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the
    barrel
    Similarity: Belongs to the HEBP family


    HEBP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HEBP2_HUMAN, Q9Y5Z4
    Function: Can promote mitochondrial permeability transition and facilitate necrotic cell death under different
    types of stress conditions. Does not bind hemin

    Phenotypes:
         1 GenomeRNAi human phenotype for HEBP2:

     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HEBP2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HEBP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HEBP2

    miRNA
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    miRTarBase miRNAs that target HEBP2:
    hsa-mir-124-3p (MIRT002643)

    Block miRNA regulation of human, mouse, rat HEBP2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HEBP2:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidHEBP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HEBP2

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEBP2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEBP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HEBP2_HUMAN, Q9Y5Z4: Cytoplasm. Mitochondrion. Note=Mainly localized to the cytoplasm with a much lower abundance
    in the mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA17098234
    GO:0005739mitochondrion IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    HEBP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HEBP2
    Interactions:

        Search GeneGlobe Interaction Network for HEBP2

    3 Interacting proteins for HEBP2 (Q9Y5Z43) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDCD6O753403I2D: score=4 
    LRPPRCP427043I2D: score=2 
    PPP2CAP677753I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HEBP2

    1 HMDB Compound for HEBP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HEBP2 gene: 
    NM_014320.2  

    Unigene Cluster for HEBP2:

    Heme binding protein 2
    Hs.486589  [show with all ESTs]
    Unigene Representative Sequence: BQ722079
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448741 ENST00000607197 ENST00000367697 ENST00000453452
    miRNA
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    Block miRNA regulation of human, mouse, rat HEBP2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HEBP2:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidHEBP2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HEBP2
    Predesigned siRNA for gene silencing in human, mouse, rat HEBP2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEBP2
    Primer
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    OriGene qPCR primer pairs and template standards for HEBP2
    OriGene qSTAR qPCR primer pairs in human, mouse for HEBP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HEBP2
      QuantiTect SYBR Green Assays in human, mouse, rat HEBP2
      QuantiFast Probe-based Assays in human, mouse, rat HEBP2

    Additional mRNA sequence: 

    AF117616.1 AF411610.1 AK057928.1 AY427823.1 BC008205.1 BC010290.1 BC016806.1 BC016807.1 
    BC093037.1 

    8 DOTS entries:

    DT.415396  DT.92438841  DT.75103339  DT.100026712  DT.100760142  DT.95277640  DT.121352738  DT.95277645 

    Selected AceView cDNA sequences (see all 188):

    AA503537 BC010290 BG655825 BM694406 BM680452 BM717995 AW029097 BE773509 
    BQ962150 BM977120 BM888523 BU627691 BQ687191 CR602643 BG655910 BM785056 
    CD673997 BQ055644 BU633687 BQ058821 BI962912 AA371862 AA166702 AW572243 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HEBP2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:        -                                       
    SP2:                          -                     
    SP3:                                                


    ECgene alternative splicing isoforms for HEBP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HEBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTATAAGT
    HEBP2 Expression
    About this image


    HEBP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    HEBP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HEBP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.486589

    UniProtKB/Swiss-Prot: HEBP2_HUMAN, Q9Y5Z4
    Tissue specificity: Detected in placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEBP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HEBP2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hebp21 , 5 heme binding protein 21, 5 84.72(n)1
    83.9(a)1
      10 (7.76 cM)5
    560161  NM_019487.31  NP_062360.11 
     185401235 
    chicken
    (Gallus gallus)
    Aves HEBP21 heme binding protein 2 58.04(n)
    48.82(a)
      424441  XM_422283.4  XP_422283.4 
    lizard
    (Anolis carolinensis)
    Reptilia HEBP26
    heme binding protein 2
    57(a)
    1 ↔ 1
    GL343200.1(1299746-1311903)
    zebrafish
    (Danio rerio)
    Actinopterygii hebp21 heme binding protein 2 54.61(n)
    50.28(a)
      393167  NM_200198.1  NP_956492.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G171001 AT1G17100 48.6(n)
    46.45(a)
      838280  NM_101570.3  NP_173153.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g02105001 Os01g0210500 46.2(n)
    39.18(a)
      4325558  NM_001048903.1  NP_001042368.1 


    ENSEMBL Gene Tree for HEBP2 (if available)
    TreeFam Gene Tree for HEBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HEBP2 gene
    HEBP12  

    HEBP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HEBP2
    PGOHUM00000240396


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HEBP2 (see all 299)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829190171,2
    --138723495(+) TCTAAC/TTTGGG 1 -- us2k10--------
    rs69349071,2
    C,F,A,H--138723498(+) AACTTG/AGGAGG 1 -- us2k111Minor allele frequency- A:0.06NS EA NA WA 1304
    rs1125651781,2
    C--138723550(+) ATGGCCGATT   
      GGAG
    /-
    CGATT
    1 -- cds11Minor allele frequency- -:0.50CSA 2
    rs735709641,2
    C--138723705(+) TCACCC/TACCTG 1 -- us2k12Minor allele frequency- T:0.05WA 120
    rs37568901,2
    C,F,A,H--138723769(+) GCCCCG/AAGGGA 1 -- us2k110Minor allele frequency- A:0.20NS EA WA CSA NA 780
    rs1878248271,2
    --138723899(+) CCCTTA/GTCGCT 1 -- us2k10--------
    rs767912231,2
    C,F--138723945(+) CCATAG/TGTGAG 1 -- us2k12Minor allele frequency- T:0.13CSA WA 120
    rs48963531,2
    C,F,A,H--138723962(+) GAAGAG/ATCACC 1 -- us2k123Minor allele frequency- A:0.23NS EA NA WA CSA 2691
    rs1483121601,2
    --138723981(+) CTTCCC/TATTTC 1 -- us2k10--------
    rs1404554051,2
    --138724132(+) ATCTCA/GGCTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HEBP2 (138724668 - 138743334 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HEBP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2752090CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HEBP2
    DNA2.0 Custom Variant and Variant Library Synthesis for HEBP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605825    OMIM disorders: --

    4 diseases for HEBP2:    
    About MalaCards
    tonsillitis    thyroiditis    prostatitis    neuronitis


    HEBP2 for disorders           About GeneDecksing


    Export disorders for HEBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HEBP2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with HEBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL. (PubMed id 17098234)1, 2, 3 Szigeti A.... Gallyas F. Jr. (FEBS Lett. 2006)
    2. Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches. (PubMed id 10640688)1, 2, 3 Zylka M.J. and Reppert S.M. (Brain Res. Mol. Brain Res. 1999)
    3. Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. (PubMed id 21639858)1, 2 Ambrosi E....Monaco H.L. (Biochem. J. 2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity. (PubMed id 11827465)1, 2 Liu L. and McKeehan W.L. (Genomics 2002)
    7. Isolation and characterization of five new soluble placental tissue proteins (PP22, PP23, PP24, PP25, PP26). (PubMed id 2018407)1, 2 Bohn H. and Winckler W. (Arch. Gynecol. Obstet. 1991)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23593 HGNC: 15716 AceView: HEBP2 Ensembl:ENSG00000051620 euGenes: HUgn23593
    ECgene: HEBP2 H-InvDB: HEBP2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HEBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HEBP2 gene:
    Search GeneIP for patents involving HEBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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