Aliases for HEBP1 Gene
Aliases for HEBP1 Gene
External Ids for HEBP1 Gene
- HGNC: 17176
- Entrez Gene: 50865
- Ensembl: ENSG00000013583
- OMIM: 605826
- UniProtKB: Q9NRV9
Previous GeneCards Identifiers for HEBP1 Gene
- GC12M012858
- GC12M013272
- GC12M013028
- GC12M013019
- GC12M013128
Summaries for HEBP1 Gene
-
The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for HEBP1 Gene
HEBP1 (Heme Binding Protein 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Circadian rythm related genes. GO annotations related to this gene include heme binding. An important paralog of this gene is HEBP2.
UniProtKB/Swiss-Prot for HEBP1 Gene
-
May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEBP1 Gene
Genomics for HEBP1 Gene
Regulatory Elements for HEBP1 Gene
Enhancers for HEBP1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HEBP1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HEBP1 gene promoter:
Regulatory Element Products
Genomic Location for HEBP1 Gene
- Chromosome:
- 12
- Start:
- 12,974,864 bp from pter
- End:
- 13,000,309 bp from pter
- Size:
- 25,446 bases
- Orientation:
- Minus strand
Genomic View for HEBP1 Gene
Genes around HEBP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.1 by Ensembl
- 12p13.1 by Entrez Gene
- 12p13.1 by HGNC
HEBP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HEBP1 Gene
Proteins for HEBP1 Gene
-
Protein details for HEBP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NRV9-HEBP1_HUMAN
- Recommended name:
- Heme-binding protein 1
- Protein Accession:
- Q9NRV9
- A8K1G2
- Q9Y5Z5
Protein attributes for HEBP1 Gene
- Size:
- 189 amino acids
- Molecular mass:
- 21097 Da
- Quaternary structure:
-
- Monomer.
Protein Expression for HEBP1 Gene
Post-translational modifications for HEBP1 Gene
Other Protein References for HEBP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HEBP1
- Invitrogen Antibodies for HEBP1
- antibodies-online Antibodies for HEBP1: See all 46
- GeneTex HEBP1 antibody for HEBP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HEBP1
Protein Products
-
OriGene Purified Proteins for HEBP1
- Search Origene for MassSpec and Protein Over-expression Lysates for HEBP1
- Origene Custom Protein Services for HEBP1
- ProSpec Recombinant Proteins for HEBP1
- antibodies-online Proteins for HEBP1: See all 12
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HEBP1
Assay Products
- antibodies-online Kits for HEBP1: See all 5
No data available for DME Specific Peptides for HEBP1 Gene
Domains & Families for HEBP1 Gene
Gene Families for HEBP1 Gene
- HGNC:
Protein Domains for HEBP1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HEBP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NRV9UniProtKB/Swiss-Prot:
HEBP1_HUMAN :- Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).
- Belongs to the HEBP family.
- Domain:
-
- Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).
- Family:
-
- Belongs to the HEBP family.
Function for HEBP1 Gene
Molecular function for HEBP1 Gene
- UniProtKB/Swiss-Prot Function:
- May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0020037 | heme binding | ISS | -- |
Phenotypes for HEBP1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HEBP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HEBP1 gene
- Search ViGene Biosciences for HEBP1
CRISPR Products
-
OriGene CRISPR knockouts for HEBP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEBP1
- GenScript: Design CRISPR guide RNA sequences for HEBP1
miRNA Products
- Search ViGene Biosciences for HEBP1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HEBP1
- Browse OriGene Inhibitory RNA Products For HEBP1
-
ViGene Biosciences ready-to-package AAV shRNAs for HEBP1 gene
Clone Products
-
OriGene ORF clones in human for HEBP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HEBP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HEBP1
-
ViGene Biosciences adenoviral particle packaged cDNA for HEBP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HEBP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HEBP1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HEBP1 Gene
Localization for HEBP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HEBP1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | 19056867 |
Pathways & Interactions for HEBP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Circadian rythm related genes | ||
Pathways by source for HEBP1 Gene
1 BioSystems pathway for HEBP1 Gene
Interacting Proteins for HEBP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007623 | circadian rhythm | TAS | 10640688 |
No data available for SIGNOR curated interactions for HEBP1 Gene
Drugs & Compounds for HEBP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| heme | Pharma | Agonist | 0 |
Transcripts for HEBP1 Gene
mRNA/cDNA for HEBP1 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (206) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HEBP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HEBP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEBP1
- GenScript: Design CRISPR guide RNA sequences for HEBP1
miRNA Products
- Search ViGene Biosciences for HEBP1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HEBP1
- Browse OriGene Inhibitory RNA Products For HEBP1
-
ViGene Biosciences ready-to-package AAV shRNAs for HEBP1 gene
Clone Products
-
OriGene ORF clones in human for HEBP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HEBP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
| SP5: |
Expression for HEBP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- Intestine (Gastrointestinal Tract)
-
Thyroid (Endocrine System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
This gene is overexpressed in Bone (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HEBP1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HEBP1 Gene:
HEBP1SOURCE GeneReport for Unigene cluster for HEBP1 Gene:
Hs.642618Evidence on tissue expression from TISSUES for HEBP1 Gene
- Liver(4.4)
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for HEBP1
-
OriGene qPCR primer pairs for HEBP1
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HEBP1 Gene
Orthologs for HEBP1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HEBP1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HEBP1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HEBP1 34 35 |
|
||
| -- 35 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Hebp1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hebp1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HEBP1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HEBP1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HEBP1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HEBP1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hebp1 34 |
|
||
| Str.10868 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23839 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | soul4 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| CSA.2043 35 |
|
ManyToMany | |||
| CSA.10114 35 |
|
ManyToMany |
- Species where no ortholog for HEBP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HEBP1 Gene
Variants for HEBP1 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000005752 | -- | 12,985,834(+) | CTTCC(C/T)AAGCA | intron-variant | |
| rs1000247209 | -- | 12,988,048(+) | TATGT(C/T)TGTGT | intron-variant | |
| rs1000298413 | -- | 13,002,120(+) | TGCCT(A/T)CTTTC | intron-variant, nc-transcript-variant, upstream-variant-2KB | |
| rs1000305683 | -- | 12,993,134(+) | CCCTC(C/G)CTCCC | intron-variant | |
| rs1000499875 | -- | 12,980,379(+) | CTGGA(A/G)TGAAG | intron-variant, nc-transcript-variant |
Residual Variation Intolerance Score:
62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.60;
45.09% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HEBP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HEBP1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEBP1 Gene
Disorders for HEBP1 Gene
Relevant External Links for HEBP1
No disorders were found for HEBP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HEBP1 Gene
Publications for HEBP1 Gene
- Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches. (PMID: 10640688) Zylka M.J. … Reppert S.M. (Brain Res. Mol. Brain Res. 1999) 2 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Characterization of a human and mouse tetrapyrrole-binding protein. (PMID: 12413491) Jacob Blackmon B. … Dailey H.A. (Arch. Biochem. Biophys. 2002) 3 4 64
Products for HEBP1 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Custom Antibody Services
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- Custom Assay Services
- OriGene Purified Proteins for HEBP1
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HEBP1
- Browse OriGene Inhibitory RNA Products For HEBP1
- OriGene qPCR primer pairs and template standards for HEBP1
- OriGene qPCR primer pairs for HEBP1
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- OriGene ORF clones in human for HEBP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for HEBP1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HEBP1
- GenScript Custom Assay Services for HEBP1
- GenScript Custom overexpressing Cell Line Services for HEBP1
- GenScript: Design CRISPR guide RNA sequences for HEBP1
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for HEBP1
- Novus Biologicals proteins and lysates for HEBP1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for HEBP1
- antibodies-online Antibodies for HEBP1: See all 46
- antibodies-online Kits for HEBP1: See all 5
- antibodies-online Proteins for HEBP1: See all 12
- Search antibodies-online for peptides
- GeneTex HEBP1 antibody for HEBP1
- Search GeneTex for Proteins for HEBP1
- ViGene Biosciences adenoviral particle packaged cDNA for HEBP1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HEBP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HEBP1 gene
- Search ViGene Biosciences for HEBP1
- Santa Cruz Biotechnology (SCBT) Antibodies for HEBP1
- Search Santa Cruz Biotechnology (SCBT) for HEBP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HEBP1
- Horizon Cell Lines for HEBP1
- Cyagen custom Knockout/knockin (KOKI) mouse models for HEBP1
- VectorBuilder custom plasmid, inducible vectors for HEBP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HEBP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HEBP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer