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Aliases for HEBP1 Gene

Aliases for HEBP1 Gene

  • Heme Binding Protein 1 2 3
  • HBP 3 4 6
  • P22HBP 3 4
  • Heme-Binding Protein 1 3
  • HEBP 3

External Ids for HEBP1 Gene

Previous GeneCards Identifiers for HEBP1 Gene

  • GC12M012858
  • GC12M013272
  • GC12M013028
  • GC12M013019
  • GC12M013128

Summaries for HEBP1 Gene

Entrez Gene Summary for HEBP1 Gene

  • The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for HEBP1 Gene

HEBP1 (Heme Binding Protein 1) is a Protein Coding gene. Diseases associated with HEBP1 include dental enamel hypoplasia and ankylosis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include heme binding. An important paralog of this gene is HEBP2.

UniProtKB/Swiss-Prot for HEBP1 Gene

  • May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEBP1 Gene

Genomics for HEBP1 Gene

Regulatory Elements for HEBP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HEBP1 Gene

Start:
12,974,864 bp from pter
End:
13,000,309 bp from pter
Size:
25,446 bases
Orientation:
Minus strand

Genomic View for HEBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HEBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEBP1 Gene

Proteins for HEBP1 Gene

  • Protein details for HEBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRV9-HEBP1_HUMAN
    Recommended name:
    Heme-binding protein 1
    Protein Accession:
    Q9NRV9
    Secondary Accessions:
    • A8K1G2
    • Q9Y5Z5

    Protein attributes for HEBP1 Gene

    Size:
    189 amino acids
    Molecular mass:
    21097 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for HEBP1 Gene

Proteomics data for HEBP1 Gene at MOPED

Post-translational modifications for HEBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HEBP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HEBP1 Gene

Domains for HEBP1 Gene

Gene Families for HEBP1 Gene

HGNC:

Protein Domains for HEBP1 Gene

Suggested Antigen Peptide Sequences for HEBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRV9

UniProtKB/Swiss-Prot:

HEBP1_HUMAN :
  • Q9NRV9
Domain:
  • Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).
Family:
  • Belongs to the HEBP family.
genes like me logo Genes that share domains with HEBP1: view

Function for HEBP1 Gene

Molecular function for HEBP1 Gene

UniProtKB/Swiss-Prot Function: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.

Gene Ontology (GO) - Molecular Function for HEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0020037 heme binding ISS --
genes like me logo Genes that share ontologies with HEBP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HEBP1 Gene

Localization for HEBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEBP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEBP1 Gene COMPARTMENTS Subcellular localization image for HEBP1 gene
Compartment Confidence
extracellular 4
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for HEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with HEBP1: view

Pathways for HEBP1 Gene

genes like me logo Genes that share pathways with HEBP1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for HEBP1 Gene

Gene Ontology (GO) - Biological Process for HEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007623 circadian rhythm TAS 10640688
genes like me logo Genes that share ontologies with HEBP1: view

Compounds for HEBP1 Gene

(1) HMDB Compounds for HEBP1 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
genes like me logo Genes that share compounds with HEBP1: view

Transcripts for HEBP1 Gene

mRNA/cDNA for HEBP1 Gene

Unigene Clusters for HEBP1 Gene

Heme binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEBP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HEBP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:

Relevant External Links for HEBP1 Gene

GeneLoc Exon Structure for
HEBP1
ECgene alternative splicing isoforms for
HEBP1

Expression for HEBP1 Gene

mRNA expression in normal human tissues for HEBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HEBP1 Gene

SOURCE GeneReport for Unigene cluster for HEBP1 Gene Hs.642618

genes like me logo Genes that share expressions with HEBP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HEBP1 Gene

Orthologs for HEBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HEBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HEBP1 35
  • 99.82 (n)
  • 100 (a)
HEBP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 78 (a)
OneToMany
HEBP1 35
  • 85.36 (n)
  • 84.66 (a)
HEBP1 36
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HEBP1 35
  • 87.06 (n)
  • 85.64 (a)
HEBP1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hebp1 35
  • 83.87 (n)
  • 86.7 (a)
Hebp1 16
Hebp1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HEBP1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HEBP1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hebp1 35
  • 85.1 (n)
  • 90.15 (a)
chicken
(Gallus gallus)
Aves HEBP1 35
  • 70.04 (n)
  • 68.62 (a)
HEBP1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HEBP1 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23839 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hebp1 35
  • 62.08 (n)
  • 56.08 (a)
Str.10868 35
zebrafish
(Danio rerio)
Actinopterygii soul4 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
ManyToMany
CSA.10114 36
  • 24 (a)
ManyToMany
CSA.2043 36
  • 26 (a)
ManyToMany
Species with no ortholog for HEBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HEBP1 Gene

ENSEMBL:
Gene Tree for HEBP1 (if available)
TreeFam:
Gene Tree for HEBP1 (if available)

Paralogs for HEBP1 Gene

Paralogs for HEBP1 Gene

genes like me logo Genes that share paralogs with HEBP1: view

Variants for HEBP1 Gene

Sequence variations from dbSNP and Humsavar for HEBP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1941 - 12,975,329(-) AATGA(C/G)ATCTG missense, reference
rs13479 -- 12,975,124(-) CTCAC(A/G)GTAGG utr-variant-3-prime
rs704228 -- 12,985,542(-) TGATC(A/G)TTTGT intron-variant
rs850918 -- 12,989,240(-) TCGGG(C/G)ACCAG intron-variant
rs850919 -- 12,989,008(-) CCATA(G/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HEBP1 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV Deletion 23290073
nsv832333 CNV Gain 17160897
nsv826260 CNV Gain 20364138

Relevant External Links for HEBP1 Gene

HapMap Linkage Disequilibrium report
HEBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEBP1 Gene

Disorders for HEBP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for HEBP1 Gene including...

Search for HEBP1 Gene in MalaCards »

(4) University of Copenhagen DISEASES for HEBP1 Gene

Relevant External Links for HEBP1

Genetic Association Database (GAD)
HEBP1
Human Genome Epidemiology (HuGE) Navigator
HEBP1
genes like me logo Genes that share disorders with HEBP1: view

No data available for UniProtKB/Swiss-Prot for HEBP1 Gene

Publications for HEBP1 Gene

  1. Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches. (PMID: 10640688) Zylka M.J. … Reppert S.M. (Brain Res. Mol. Brain Res. 1999) 2 3 4
  2. Characterization of a human and mouse tetrapyrrole-binding protein. (PMID: 12413491) Jacob Blackmon B. … Dailey H.A. (Arch. Biochem. Biophys. 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for HEBP1 Gene

Sources for HEBP1 Gene

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