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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HEBP1 Gene

protein-coding   GIFtS: 54
GCID: GC12M013128

Heme Binding Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heme Binding Protein 11 2
HBP2 3 5
p22HBP2 3
HEBP2
Heme-Binding Protein 12

External Ids:    HGNC: 171761   Entrez Gene: 508652   Ensembl: ENSG000000135837   OMIM: 6058265   UniProtKB: Q9NRV93   

Export aliases for HEBP1 gene to outside databases

Previous GC identifers: GC12M012858 GC12M013272 GC12M013028 GC12M013019


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HEBP1 Gene:
The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein
includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for
formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and
dendritic cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for HEBP1 Gene: 
HEBP1 (heme binding protein 1) is a protein-coding gene. Diseases associated with HEBP1 include dental enamel hypoplasia, and root resorption, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include heme binding. An important paralog of this gene is HEBP2.

UniProtKB/Swiss-Prot: HEBP1_HUMAN, Q9NRV9
Function: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these
potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds
metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HEBP1 gene promoter:
         Max1   USF1   Nkx2-5   C/EBPalpha   CREB   FOXO4   USF-1   deltaCREB   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHEBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HEBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1   Ensembl cytogenetic band:  12p13.1   HGNC cytogenetic band: 12p13.2

HEBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HEBP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M013128:  view genomic region     (about GC identifiers)

Start:
13,127,798 bp from pter      End:
13,153,243 bp from pter
Size:
25,446 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HEBP1_HUMAN, Q9NRV9 (See protein sequence)
Recommended Name: Heme-binding protein 1  
Size: 189 amino acids; 21097 Da
Subunit: Monomer
Subcellular location: Cytoplasm
Secondary accessions: A8K1G2 Q9Y5Z5

Explore the universe of human proteins at neXtProt for HEBP1: NX_Q9NRV9

Explore proteomics data for HEBP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRV9

  • HEBP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HEBP1 Protein Expression
    REFSEQ proteins: NP_057071.2  
    ENSEMBL proteins: 
     ENSP00000014930   ENSP00000442020   ENSP00000441678  
    Reactome Protein details: Q9NRV9
    Human Recombinant Protein Products for HEBP1: 
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    Novus Biologicals HEBP1 Proteins
    Novus Biologicals HEBP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HEBP1
    Cloud-Clone Corp. Proteins for HEBP1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol IEA--

    HEBP1 for ontologies           About GeneDecksing



    HEBP1 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for HEBP1 
    Cloud-Clone Corp. CLIAs for HEBP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011256 Reg_factor_effector_bac
     IPR006917 SOUL_haem-bd

    Graphical View of Domain Structure for InterPro Entry Q9NRV9

    ProtoNet protein and cluster: Q9NRV9

    UniProtKB/Swiss-Prot: HEBP1_HUMAN, Q9NRV9
    Domain: Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the
    barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure
    (By similarity)
    Similarity: Belongs to the HEBP family


    HEBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HEBP1_HUMAN, Q9NRV9
    Function: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these
    potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds
    metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0020037heme binding ISS--
         
    HEBP1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HEBP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HEBP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HEBP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HEBP1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HEBP1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HEBP1:
    hsa-miR-224
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    Inhib. RNA
    Products:
        
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEBP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HEBP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Formyl peptide receptors bind formyl peptides and many other ligands
    Formyl peptide receptors bind formyl peptides and many other ligands

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for HEBP1 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Formyl peptide receptors bind formyl peptides and many other ligands
    Signal Transduction
    Signaling by GPCR



    HEBP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HEBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/146 Interacting proteins for HEBP1 (Q9NRV93 ENSP000000149304) via UniProtKB, MINT, STRING, and/or I2D (see all 146)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOT1P171743I2D: score=1 
    KCNMA1Q127913I2D: score=1 
    ADCY9ENSP000002940164STRING: ENSP00000294016
    APLNENSP000003054644STRING: ENSP00000305464
    APPENSP000002849814STRING: ENSP00000284981
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007623circadian rhythm TAS10640688

    HEBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HEBP1

    1 HMDB Compound for HEBP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--

    Search CenterWatch for drugs/clinical trials and news about HEBP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HEBP1 gene: 
    NM_015987.4  

    Unigene Cluster for HEBP1:

    Heme binding protein 1
    Hs.642618  [show with all ESTs]
    Unigene Representative Sequence: AK131565
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000014930(uc001rbd.3) ENST00000540916 ENST00000535636 ENST00000536942

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate HEBP1:
    hsa-miR-224
    SwitchGear 3'UTR luciferase reporter plasmidHEBP1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for HEBP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEBP1
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    Sirion Biotech Customized lentivirus for stable overexpression of HEBP1 
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    Primer
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    OriGene qPCR primer pairs and template standards for HEBP1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEBP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEBP1

    Additional mRNA sequence: 

    AF117615.1 AF167473.1 AK131565.1 AK289877.1 BC016277.2 BT007294.1 

    9 DOTS entries:

    DT.316952  DT.100025920  DT.97844529  DT.99957794  DT.91747384  DT.121179795  DT.91747371  DT.91747376 
    DT.95177183 

    24/206 AceView cDNA sequences (see all 206):

    BQ233491 BM841206 BM723817 BM698230 W95461 N22337 C21377 BP429762 
    AA469923 BX337013 BM698491 AA302285 AW451319 BM921953 BE882209 AA302284 
    BF475981 BC016277 BU619957 CR621039 BF594812 AA343240 AW948833 BM782315 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HEBP1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
    SP1:                                -     -     -                                 
    SP2:                                -     -                                       
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for HEBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HEBP1 expression in normal human tissues (normalized intensities)      HEBP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCATATAC
    HEBP1 Expression
    About this image


    HEBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             blood vessel   
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow

    See HEBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HEBP1

    SOURCE GeneReport for Unigene cluster: Hs.642618
        SABiosciences Expression via Pathway-Focused PCR Array including HEBP1: 
              Circadian Rhythms in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HEBP1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hebp11 , 5 heme binding protein 11, 5 83.87(n)1
    86.7(a)1
      6 (65.93 cM)5
    151991  NM_013546.21  NP_038574.21 
     1351375195 
    chicken
    (Gallus gallus)
    Aves HEBP11 heme binding protein 1 70.04(n)
    68.62(a)
      417961  NM_001030754.1  NP_001025925.1 
    lizard
    (Anolis carolinensis)
    Reptilia HEBP16
    Uncharacterized protein
    58(a)
    1 ↔ 1
    5(27471543-27484767)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238392 Xenopus laevis transcribed sequence with weak similarity more 74.96(n)    BX847941.1 
    zebrafish
    (Danio rerio)
    Actinopterygii soul56
    si:ch1073-110a20.46
    si:ch1073-110a20.4
    23(a)
    16(a)
    possible ortholog
    possible ortholog
    3(54113934-54123253)
    1(59899717-59903497)


    ENSEMBL Gene Tree for HEBP1 (if available)
    TreeFam Gene Tree for HEBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HEBP1 gene
    HEBP22  

    HEBP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/359 SNPs in HEBP1 are shown (see all 359)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs562950091,2
    C--13014365(+) GTATG-/AGCCACT 1 -- int11Minor allele frequency- AG:0.00NA 2
    rs1502954711,2
    --13127312(+) ACTCAC/TGGGCT 1 -- ds50010--------
    rs1845929431,2
    --13127348(+) CTTCCC/TGCTCA 1 -- ds50010--------
    rs1895632271,2
    --13127373(+) TGTCCC/TTCTCT 1 -- ds50010--------
    rs1815735471,2
    --13127523(+) GCAATA/GATTTT 1 -- ds50010--------
    rs1380624681,2
    --13127547(+) CTCTTA/GTGACT 1 -- ds50010--------
    rs1857130161,2
    --13127566(+) CCTTCA/GCAGAC 1 -- ds50010--------
    rs1420441071,2
    --13127786(+) AATAAC/TTACAC 1 -- ds50010--------
    rs1889584251,2
    --13127939(+) TAGAAA/CATCAG 1 -- ut310--------
    rs1468423301,2
    C--13127998(+) TCTATC/TGCAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HEBP1 (13127798 - 13153243 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HEBP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745567CNV Deletion23290073
    nsv832333CNV Gain17160897
    nsv826260CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HEBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for HEBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605826    OMIM disorders: --

    5 diseases for HEBP1:    About MalaCards
    dental enamel hypoplasia    root resorption    ankylosis    rickets
    breast cancer

    4 diseases from the University of Copenhagen DISEASES database for HEBP1:
    Ankylosis     Root resorption     Dental enamel hypoplasia     Rickets

    HEBP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HEBP1
    Human Genome Epidemiology (HuGE) Navigator: HEBP1 (4 documents)

    Export disorders for HEBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HEBP1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with HEBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches. (PubMed id 10640688)1, 2, 3 Zylka M.J. and Reppert S.M. (1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Characterization of a human and mouse tetrapyrrole-binding protein. (PubMed id 12413491)1, 2 Jacob Blackmon B.... Dailey H.A. (2002)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3. (PubMed id 21709160)1 Devosse T....Parmentier M. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50865 HGNC: 17176 AceView: HEBP1 Ensembl:ENSG00000013583 euGenes: HUgn50865
    ECgene: HEBP1 H-InvDB: HEBP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HEBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HEBP1 gene:
    Search GeneIP for patents involving HEBP1

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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