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Aliases for HEBP1 Gene

Aliases for HEBP1 Gene

  • Heme Binding Protein 1 2 3 5
  • P22HBP 3 4
  • HBP 3 4
  • HEBP 3

External Ids for HEBP1 Gene

Previous GeneCards Identifiers for HEBP1 Gene

  • GC12M012858
  • GC12M013272
  • GC12M013028
  • GC12M013019
  • GC12M013128

Summaries for HEBP1 Gene

Entrez Gene Summary for HEBP1 Gene

  • The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for HEBP1 Gene

HEBP1 (Heme Binding Protein 1) is a Protein Coding gene. Diseases associated with HEBP1 include teeth hard tissue disease. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include heme binding. An important paralog of this gene is HEBP2.

UniProtKB/Swiss-Prot for HEBP1 Gene

  • May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEBP1 Gene

Genomics for HEBP1 Gene

Regulatory Elements for HEBP1 Gene

Enhancers for HEBP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HEBP1 on UCSC Golden Path with GeneCards custom track

Promoters for HEBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HEBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HEBP1 Gene

Chromosome:
12
Start:
12,974,864 bp from pter
End:
13,000,309 bp from pter
Size:
25,446 bases
Orientation:
Minus strand

Genomic View for HEBP1 Gene

Genes around HEBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HEBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HEBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEBP1 Gene

Proteins for HEBP1 Gene

  • Protein details for HEBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRV9-HEBP1_HUMAN
    Recommended name:
    Heme-binding protein 1
    Protein Accession:
    Q9NRV9
    Secondary Accessions:
    • A8K1G2
    • Q9Y5Z5

    Protein attributes for HEBP1 Gene

    Size:
    189 amino acids
    Molecular mass:
    21097 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for HEBP1 Gene

Proteomics data for HEBP1 Gene at MOPED

Post-translational modifications for HEBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HEBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HEBP1 Gene

Domains & Families for HEBP1 Gene

Gene Families for HEBP1 Gene

Protein Domains for HEBP1 Gene

Suggested Antigen Peptide Sequences for HEBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRV9

UniProtKB/Swiss-Prot:

HEBP1_HUMAN :
  • Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).
  • Belongs to the HEBP family.
Domain:
  • Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).
Family:
  • Belongs to the HEBP family.
genes like me logo Genes that share domains with HEBP1: view

Function for HEBP1 Gene

Molecular function for HEBP1 Gene

UniProtKB/Swiss-Prot Function:
May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.
genes like me logo Genes that share phenotypes with HEBP1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HEBP1 Gene

Localization for HEBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEBP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEBP1 Gene COMPARTMENTS Subcellular localization image for HEBP1 gene
Compartment Confidence
extracellular 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with HEBP1: view

Pathways & Interactions for HEBP1 Gene

genes like me logo Genes that share pathways with HEBP1: view

Interacting Proteins for HEBP1 Gene

Gene Ontology (GO) - Biological Process for HEBP1 Gene

None

No data available for SIGNOR curated interactions for HEBP1 Gene

Drugs & Compounds for HEBP1 Gene

(1) Drugs for HEBP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0
genes like me logo Genes that share compounds with HEBP1: view

Transcripts for HEBP1 Gene

Unigene Clusters for HEBP1 Gene

Heme binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HEBP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:

Relevant External Links for HEBP1 Gene

GeneLoc Exon Structure for
HEBP1
ECgene alternative splicing isoforms for
HEBP1

Expression for HEBP1 Gene

mRNA expression in normal human tissues for HEBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HEBP1 Gene

This gene is overexpressed in Bone (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HEBP1 Gene



SOURCE GeneReport for Unigene cluster for HEBP1 Gene Hs.642618

genes like me logo Genes that share expression patterns with HEBP1: view

Protein tissue co-expression partners for HEBP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HEBP1 Gene

Orthologs for HEBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HEBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HEBP1 35
  • 85.36 (n)
  • 84.66 (a)
-- 36
  • 78 (a)
OneToMany
HEBP1 36
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HEBP1 35
  • 87.06 (n)
  • 85.64 (a)
HEBP1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hebp1 35
  • 83.87 (n)
  • 86.7 (a)
Hebp1 16
Hebp1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HEBP1 35
  • 99.82 (n)
  • 100 (a)
HEBP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hebp1 35
  • 85.1 (n)
  • 90.15 (a)
oppossum
(Monodelphis domestica)
Mammalia HEBP1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HEBP1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves HEBP1 35
  • 70.04 (n)
  • 68.62 (a)
HEBP1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HEBP1 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hebp1 35
  • 62.08 (n)
  • 56.08 (a)
Str.10868 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23839 35
zebrafish
(Danio rerio)
Actinopterygii soul4 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
ManyToMany
CSA.10114 36
  • 24 (a)
ManyToMany
CSA.2043 36
  • 26 (a)
ManyToMany
Species with no ortholog for HEBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HEBP1 Gene

ENSEMBL:
Gene Tree for HEBP1 (if available)
TreeFam:
Gene Tree for HEBP1 (if available)

Paralogs for HEBP1 Gene

Paralogs for HEBP1 Gene

genes like me logo Genes that share paralogs with HEBP1: view

Variants for HEBP1 Gene

Sequence variations from dbSNP and Humsavar for HEBP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_053363 -
rs10845693 -- 12,991,419(+) GCTTA(A/G)TGCTC intron-variant
rs12814804 -- 12,987,614(+) TCTTT(C/T)TCTCT intron-variant
rs12815728 -- 12,993,563(+) CTCTC(C/T)TTAGC intron-variant
rs12820498 -- 12,987,612(+) TCTCT(C/T)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HEBP1 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV Deletion 23290073
nsv832333 CNV Gain 17160897
nsv826260 CNV Gain 20364138

Variation tolerance for HEBP1 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HEBP1 Gene

HapMap Linkage Disequilibrium report
HEBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEBP1 Gene

Disorders for HEBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HEBP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
teeth hard tissue disease
- elite association - COSMIC cancer census association via MalaCards
Search HEBP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HEBP1

Genetic Association Database (GAD)
HEBP1
Human Genome Epidemiology (HuGE) Navigator
HEBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HEBP1
genes like me logo Genes that share disorders with HEBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HEBP1 Gene

Publications for HEBP1 Gene

  1. Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches. (PMID: 10640688) Zylka M.J. … Reppert S.M. (Brain Res. Mol. Brain Res. 1999) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3. (PMID: 21709160) Devosse T. … Parmentier M. (J. Immunol. 2011) 3

Products for HEBP1 Gene

Sources for HEBP1 Gene

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