Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HEBP1 Gene

protein-coding   GIFtS: 49
GCID: GC12M013128

heme binding protein 1

 Explore 5 diseases affiliated with
HEBP1 via our new
 Human Malady Compendium 
Biological research products
for HEBP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Heme Binding Protein 11 2
HBP1 2 3 5
HEBP1 2
P22HBP1
Heme-Binding Protein 12

External Ids:    HGNC: 171761   Entrez Gene: 508652   Ensembl: ENSG000000135837   OMIM: 6058265   UniProtKB: Q9NRV93   

Export aliases for HEBP1 gene to outside databases

Previous GC identifers: GC12M012858 GC12M013272 GC12M013028 GC12M013019


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HEBP1:
The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a
natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide
receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HEBP1_HUMAN, Q9NRV9
Function: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially
toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free
porphyrins and N-methylprotoporphyrin with similar affinities




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HEBP1 gene promoter:
         Max1   USF1   Nkx2-5   C/EBPalpha   CREB   FOXO4   USF-1   deltaCREB   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHEBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HEBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1   Ensembl cytogenetic band:  12p13.1   HGNC cytogenetic band: 12p13.2

HEBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HEBP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M013128:  view genomic region     (about GC identifiers)

Start:
13,127,798 bp from pter      End:
13,153,243 bp from pter
Size:
25,446 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HEBP1_HUMAN, Q9NRV9 (See protein sequence)
Recommended Name: Heme-binding protein 1  
Size: 189 amino acids; 21097 Da
Subunit: Monomer
Subcellular location: Cytoplasm
Secondary accessions: A8K1G2 Q9Y5Z5

Explore the universe of human proteins at neXtProt for HEBP1: NX_Q9NRV9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NRV9

  • HEBP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057071.2  
    ENSEMBL proteins: 
     ENSP00000014930   ENSP00000442020   ENSP00000441678  
    Reactome Protein details: Q9NRV9
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HEBP1
    OriGene Protein Over-expression Lysate: HEBP1
    OriGene Custom Protein Services for HEBP1 
    GenScript Custom Purified and Recombinant Proteins Services for HEBP1
    Novus Biologicals HEBP1 Proteins
    Novus Biologicals HEBP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HEBP1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol IEA--


    HEBP1 for ontologies           About GeneDecksing



    HEBP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HEBP1 
    GenScript Custom Superior Antibodies Services for HEBP1
    Novus Biologicals HEBP1 Antibodies
    Search for Antibodies for HEBP1 at Abcam  
    Uscn Antibodies for HEBP1
    Search ThermoFisher Antibodies for HEBP1

    Assay Products for HEBP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HEBP1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HEBP1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HEBP1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011256 Reg_factor_effector_bac
     IPR006917 SOUL_haem-bd

    Graphical View of Domain Structure for InterPro Entry Q9NRV9

    ProtoNet protein and cluster: Q9NRV9

    UniProtKB/Swiss-Prot: HEBP1_HUMAN, Q9NRV9
    Domain: Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the
    barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By
    similarity)
    Similarity: Belongs to the HEBP family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HEBP1_HUMAN, Q9NRV9
    Function: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially
    toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free
    porphyrins and N-methylprotoporphyrin with similar affinities

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: HEBP1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HEBP1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HEBP1:
    hsa-miR-224
    SwitchGear 3'UTR luciferase reporter plasmidHEBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEBP1 (see all 7)
    OriGene shRNA RFP: HEBP1
    OriGene siRNA: HEBP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEBP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HEBP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEBP1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEBP1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for HEBP1
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HEBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEBP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HEBP1
    Search LifeMap BioReagents cell lines for HEBP1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEBP1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0020037heme binding ISS--


    HEBP1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)1.00
    Peptide ligand-binding receptors0.61
    GPCR ligand binding0.75
    G alpha (i) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR1.00
    Signal Transduction0.56
    GPCR downstream signaling0.89
    3Formyl peptide receptors bind formyl peptides and many other ligands
    Formyl peptide receptors bind formyl peptides and many other ligands1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for HEBP1 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Formyl peptide receptors bind formyl peptides and many other ligands
    Signal Transduction
    Signaling by GPCR



    HEBP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HEBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/146 Interacting proteins for HEBP1 (Q9NRV93 ENSP000000149304) via UniProtKB, MINT, STRING, and/or I2D (see all 146)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOT1P171743I2D: score=1 
    KCNMA1Q127913I2D: score=1 
    ADCY9ENSP000002940164STRING: ENSP00000294016
    APLNENSP000003054644STRING: ENSP00000305464
    APPENSP000002849814STRING: ENSP00000284981
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007623circadian rhythm TAS10640688


    HEBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HEBP1

    1 HMDB Compound for HEBP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Search CenterWatch for drugs/clinical trials and news about HEBP1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HEBP1 gene: 
    NM_015987.4  

    Unigene Cluster for HEBP1:

    Heme binding protein 1
    Hs.642618  [show with all ESTs]
    Unigene Representative Sequence: AK131565
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000014930(uc001rbd.3) ENST00000540916 ENST00000535636 ENST00000536942


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: HEBP1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HEBP1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HEBP1:
    hsa-miR-224
    SwitchGear 3'UTR luciferase reporter plasmidHEBP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEBP1 (see all 7)
    OriGene shRNA RFP: HEBP1
    OriGene siRNA: HEBP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEBP1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEBP1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEBP1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for HEBP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HEBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEBP1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEBP1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HEBP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEBP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEBP1

    Additional cDNA sequence: 

    AF117615.1 AF167473.1 AK131565.1 AK289877.1 BC016277.2 BT007294.1 

    9 DOTS entries:

    DT.316952  DT.100025920  DT.97844529  DT.99957794  DT.91747384  DT.121179795  DT.91747371  DT.91747376 
    DT.95177183 

    24/206 AceView cDNA sequences (see all 206):

    AA699304 BE782977 BX375275 AA469923 C21377 BM921953 BM841206 BM723817 
    BM698491 AW948833 CF126250 BF594812 AW451319 BP429762 AA302284 BQ233491 
    AA365510 BE882209 BM782315 AA365509 CR613893 W95461 BM921650 BX104418 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HEBP1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
    SP1:                                -     -     -                                 
    SP2:                                -     -                                       
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for HEBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HEBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCCATATAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See HEBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HEBP1

    SOURCE GeneReport for Unigene cluster: Hs.642618
        SABiosciences Expression via Pathway-Focused PCR Array including HEBP1: 
              Circadian Rhythms in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEBP1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HEBP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEBP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HEBP1 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hebp11 , 5 heme binding protein 11, 5 83.87(n)1
    86.7(a)1
      6 (65.93 cM)5
    151991  NM_013546.21  NP_038574.21 
     1351375195 
    chicken
    (Gallus gallus)
    Aves HEBP11 heme binding protein 1 70.04(n)
    68.62(a)
      417961  NM_001030754.1  NP_001025925.1 
    lizard
    (Anolis carolinensis)
    Reptilia HEBP16
    --
    63(a)
    1 ↔ 1
    5(27471664-27480183)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238392 Xenopus laevis transcribed sequence with weak similarity more 74.96(n)    BX847941.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G171006
    AT1G784606
    (see all 3)
    SOUL heme-binding protein
    (see all 3)
    18(a)
    16(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    1(5844676-5845661)
    1(29518316-29519323)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    SOUL heme-binding protein, putative, expressed
    19(a)
    18(a)
    many ↔ many
    many ↔ many
    1(6006818-6008027)
    1(7469710-7471743)


    ENSEMBL Gene Tree for HEBP1 (if available)
    TreeFam Gene Tree for HEBP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HEBP1 gene
    HEBP22  

    HEBP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/473 NCBI SNPs in HEBP1 are shown (see all 473    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502954711,2
    --13127312(+) ACTCAC/TGGGCT 1 -- ds50010--------
    rs1845929431,2
    --13127348(+) CTTCCC/TGCTCA 1 -- ds50010--------
    rs1895632271,2
    --13127373(+) TGTCCC/TTCTCT 1 -- ds50010--------
    rs1815735471,2
    --13127523(+) GCAATA/GATTTT 1 -- ds50010--------
    rs1380624681,2
    --13127547(+) CTCTTA/GTGACT 1 -- ds50010--------
    rs1857130161,2
    --13127566(+) CCTTCA/GCAGAC 1 -- ds50010--------
    rs1420441071,2
    --13127786(+) AATAAC/TTACAC 1 -- ds50010--------
    rs1889584251,2
    --13127939(+) TAGAAA/CATCAG 1 -- ut310--------
    rs1468423301,2
    --13127998(+) TCTATC/TGCAGA 1 -- ut310--------
    rs730687961,2
    C,--13128022(+) ATGAGA/GAGGAT 1 -- ut311Minor allele frequency- G:0.00NA 120

    HapMap Linkage Disequilibrium report for HEBP1 (13127798 - 13153243 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HEBP1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for HEBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HEBP1 for disorders           About GeneDecksing

    OMIM gene information: 605826    OMIM disorders: --

    5 diseases for HEBP1:    About MalaCards
    dental enamel hypoplasia    root resorption    ankylosis    rickets
    breast cancer

    4 diseases from the University of Copenhagen DISEASES database for HEBP1:
    Ankylosis     Root resorption     Rickets     Dental enamel hypoplasia
    Human Genome Epidemiology (HuGE) Navigator: HEBP1 (4 documents)

    Export disorders for HEBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HEBP1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with HEBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches. (PubMed id 10640688)1, 2, 3 Zylka M.J. and Reppert S.M. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Characterization of a human and mouse tetrapyrrole-binding protein. (PubMed id 12413491)1, 2 Jacob Blackmon B.... Dailey H.A. (2002)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3. (PubMed id 21709160)1 Devosse T....Parmentier M. (2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins. (PubMed id 20800521)1 Micaelo N.M....FAclix V. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50865 HGNC: 17176 AceView: HEBP1 Ensembl:ENSG00000013583 euGenes: HUgn50865
    ECgene: HEBP1 H-InvDB: HEBP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HEBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HEBP1 gene:
    Search GeneIP for patents involving HEBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HEBP1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEBP1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEBP1  
     OriGene Protein Over-expression Lysate for HEBP1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HEBP1   OriGene 3'-UTR Clone for HEBP1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEBP1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEBP1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for HEBP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HEBP1   OriGene Custom Protein Services for HEBP1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HEBP1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEBP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEBP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEBP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEBP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEBP1
     GenScript Custom Purified and Recombinant Proteins Services for HEBP1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for HEBP1
     GenScript Custom Assay Services for HEBP1 GenScript Custom Superior Antibodies Services for HEBP1
     GenScript Custom overexpressing Cell Line Services for HEBP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HEBP1 promoter
     Search Chromatin IP Primers for HEBP1
     RT2 qPCR Primer Assay in human, mouse, rat HEBP1
     Search GNC Networks for HEBP1
     SABiosciences PCR Arrays including human, mouse, rat HEBP1
     Search Tocris compounds for HEBP1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HEBP1 antibodies
     HEBP1 proteins
     HEBP1 lysates
     Search for Antibodies for HEBP1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HEBP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HEBP1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HEBP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEBP1
     SwitchGear 3'UTR luciferase reporter plasmids for HEBP1
     SwitchGear Promoter luciferase reporter plasmids for HEBP1
     Search ThermoFisher Antibodies for HEBP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEBP1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HEBP1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4