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Aliases for HEATR9 Gene

Aliases for HEATR9 Gene

  • HEAT Repeat Containing 9 2 3 5
  • HEAT Repeat-Containing Protein 9 3 4
  • C17orf66 3 4
  • Chromosome 17 Open Reading Frame 66 2
  • Protein HEATR9 3

External Ids for HEATR9 Gene

Previous HGNC Symbols for HEATR9 Gene

  • C17orf66

Previous GeneCards Identifiers for HEATR9 Gene

  • GC17M034182

Summaries for HEATR9 Gene

GeneCards Summary for HEATR9 Gene

HEATR9 (HEAT Repeat Containing 9) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

Additional gene information for HEATR9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEATR9 Gene

Genomics for HEATR9 Gene

GeneHancer (GH) Regulatory Elements for HEATR9 Gene

Promoters and enhancers for HEATR9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I035869 Promoter 0.5 EPDnew 550.8 +0.0 8 0.1 ENSG00000270240 HEATR9 LOC105371744 GC17P035863
GH17I035807 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 6.2 +59.5 59538 3.9 PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000270829 TAF15 C17orf50 GAS2L2 LIG3 MMP28 HEATR9 RDM1 AP2B1 ENSG00000270894
GH17I036072 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 9.5 -203.9 -203923 0.4 HDGF CTCF BATF KLF5 IRF4 RAD21 RELA ZFHX2 EGR1 ZNF143 ENSG00000277089 HEATR9 LYZL6 C17orf50 CCL5 MYO19 RDM1 CCL18
GH17I035888 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5.6 -22.4 -22358 5.5 PKNOX1 SMAD1 RB1 BMI1 BATF IRF4 YY1 ZNF335 ZNF207 ATF7 ENSG00000271394 GC17M035888 CCL3 CCL4 CCL3L3 TAF15 GAS2L2 C17orf50 HEATR9 CCL5
GH17I035895 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 5.6 -30.4 -30411 8.1 PKNOX1 FEZF1 RAD21 ETV6 BCLAF1 IKZF2 RUNX3 SMARCA5 ZNF680 CBFB C17orf50 CCL5 GAS2L2 TAF15 HEATR9 SLFN12L SLFN14 GC17M035888 GC17M035909 PIR57610
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HEATR9 on UCSC Golden Path with GeneCards custom track

Genomic Locations for HEATR9 Gene

Genomic Locations for HEATR9 Gene
chr17:35,854,946-35,868,891
(GRCh38/hg38)
Size:
13,946 bases
Orientation:
Minus strand
chr17:34,181,955-34,195,895
(GRCh37/hg19)

Genomic View for HEATR9 Gene

Genes around HEATR9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HEATR9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HEATR9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEATR9 Gene

Proteins for HEATR9 Gene

  • Protein details for HEATR9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RTY3-HEAT9_HUMAN
    Recommended name:
    Protein HEATR9
    Protein Accession:
    A2RTY3
    Secondary Accessions:
    • B4DX21
    • B4DXA4
    • B4DXF0
    • Q8N4R4
    • Q96M46

    Protein attributes for HEATR9 Gene

    Size:
    570 amino acids
    Molecular mass:
    65681 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HEATR9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HEATR9 Gene

Post-translational modifications for HEATR9 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HEATR9 Gene

Domains & Families for HEATR9 Gene

Gene Families for HEATR9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HEATR9 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HEATR9: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HEATR9 Gene

Function for HEATR9 Gene

Phenotypes for HEATR9 Gene

genes like me logo Genes that share phenotypes with HEATR9: view

Animal Model Products

CRISPR Products

miRNA for HEATR9 Gene

miRTarBase miRNAs that target HEATR9

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HEATR9 Gene

Localization for HEATR9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HEATR9 gene
Compartment Confidence
cytosol 2
plasma membrane 1
nucleus 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HEATR9 Gene

Pathways & Interactions for HEATR9 Gene

SuperPathways for HEATR9 Gene

No Data Available

Interacting Proteins for HEATR9 Gene

Selected Interacting proteins: A2RTY3-HEAT9_HUMAN for HEATR9 Gene via UniProtKB

Symbol External ID(s) Details
HEMK1

Gene Ontology (GO) - Biological Process for HEATR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
genes like me logo Genes that share ontologies with HEATR9: view

No data available for Pathways by source and SIGNOR curated interactions for HEATR9 Gene

Drugs & Compounds for HEATR9 Gene

No Compound Related Data Available

Transcripts for HEATR9 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HEATR9 Gene

No ASD Table

Relevant External Links for HEATR9 Gene

GeneLoc Exon Structure for
HEATR9
ECgene alternative splicing isoforms for
HEATR9

Expression for HEATR9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HEATR9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HEATR9 Gene

This gene is overexpressed in Testis (x35.4) and Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for HEATR9 Gene

This gene is overexpressed in Bone marrow stromal cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HEATR9 Gene



Protein tissue co-expression partners for HEATR9 Gene

NURSA nuclear receptor signaling pathways regulating expression of HEATR9 Gene:

HEATR9

Evidence on tissue expression from TISSUES for HEATR9 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with HEATR9: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HEATR9 Gene

Orthologs for HEATR9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for HEATR9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf66 33
  • 98.07 (n)
cow
(Bos Taurus)
Mammalia C19H17orf66 33
  • 79.51 (n)
mouse
(Mus musculus)
Mammalia Gm11435 33
  • 75.7 (n)
Heatr9 16
rat
(Rattus norvegicus)
Mammalia RGD1559875 33
  • 75.52 (n)
Species where no ortholog for HEATR9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HEATR9 Gene

ENSEMBL:
Gene Tree for HEATR9 (if available)
TreeFam:
Gene Tree for HEATR9 (if available)

Paralogs for HEATR9 Gene

No data available for Paralogs for HEATR9 Gene

Variants for HEATR9 Gene

Sequence variations from dbSNP and Humsavar for HEATR9 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
VAR_035685 A breast cancer sample p.Ile330Met
rs1000061814 -- 35,866,256(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000478954 -- 35,858,319(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000560836 -- 35,868,823(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000672597 -- 35,864,659(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HEATR9 Gene

Variant ID Type Subtype PubMed ID
esv3640458 CNV loss 21293372
esv3892999 CNV loss 25118596
nsv1059795 CNV gain 25217958
nsv1079030 OTHER inversion 25765185
nsv960467 CNV duplication 23825009

Variation tolerance for HEATR9 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.80; 66.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HEATR9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HEATR9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEATR9 Gene

Disorders for HEATR9 Gene

Additional Disease Information for HEATR9

No disorders were found for HEATR9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HEATR9 Gene

Publications for HEATR9 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S … Seielstad M (Genes and immunity 2010) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58

Products for HEATR9 Gene

Sources for HEATR9 Gene

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