Aliases for HEATR9 Gene
Aliases for HEATR9 Gene
External Ids for HEATR9 Gene
- HGNC: 26548
- Entrez Gene: 256957
- Ensembl: ENSG00000270379
- UniProtKB: A2RTY3
Previous HGNC Symbols for HEATR9 Gene
- C17orf66
Previous GeneCards Identifiers for HEATR9 Gene
- GC17M034182
Summaries for HEATR9 Gene
GeneCards Summary for HEATR9 Gene
HEATR9 (HEAT Repeat Containing 9) is a Protein Coding gene. GO annotations related to this gene include binding.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEATR9 Gene
Genomics for HEATR9 Gene
Regulatory Elements for HEATR9 Gene
Enhancers for HEATR9 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HEATR9 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HEATR9 Gene
- Chromosome:
- 17
- Start:
- 35,854,946 bp from pter
- End:
- 35,868,891 bp from pter
- Size:
- 13,946 bases
- Orientation:
- Minus strand
Genomic View for HEATR9 Gene
Genes around HEATR9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Ensembl
- 17q12 by Entrez Gene
- 17q12 by HGNC
HEATR9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HEATR9 Gene
Proteins for HEATR9 Gene
-
Protein details for HEATR9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A2RTY3-HEAT9_HUMAN
- Recommended name:
- Protein HEATR9
- Protein Accession:
- A2RTY3
- B4DX21
- B4DXA4
- B4DXF0
- Q8N4R4
- Q96M46
Protein attributes for HEATR9 Gene
- Size:
- 570 amino acids
- Molecular mass:
- 65681 Da
- Quaternary structure:
- No Data Available
Protein Expression for HEATR9 Gene
Post-translational modifications for HEATR9 Gene
Other Protein References for HEATR9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HEATR9
- Novus Biologicals Antibodies for HEATR9
-
Abcam antibodies for HEATR9
- Invitrogen Antibodies for HEATR9
- Search GeneTex for Antibodies for HEATR9
-
Santa Cruz Biotechnology (SCBT) Antibodies for HEATR9
Protein Products
-
OriGene Purified Proteins for HEATR9
- Search Origene for MassSpec and Protein Over-expression Lysates for HEATR9
- Origene Custom Protein Services for HEATR9
- Search GeneTex for Proteins for HEATR9
-
Abcam proteins for HEATR9
Assay Products
No data available for DME Specific Peptides for HEATR9 Gene
Domains & Families for HEATR9 Gene
Protein Domains for HEATR9 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HEATR9 Gene
Function for HEATR9 Gene
Phenotypes for HEATR9 Gene
- GenomeRNAi human phenotypes for HEATR9:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HEATR9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HEATR9 gene
- Search ViGene Biosciences for HEATR9
CRISPR Products
-
OriGene CRISPR knockouts for HEATR9
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEATR9
- GenScript: Design CRISPR guide RNA sequences for HEATR9
miRNA for HEATR9 Gene
- miRTarBase miRNAs that target HEATR9
miRNA Products
- Search ViGene Biosciences for HEATR9
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HEATR9
- Browse OriGene Inhibitory RNA Products For HEATR9
-
ViGene Biosciences ready-to-package AAV shRNAs for HEATR9 gene
Clone Products
-
OriGene ORF clones in human for HEATR9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HEATR9
-
ViGene Biosciences adenoviral particle packaged cDNA for HEATR9 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HEATR9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HEATR9 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HEATR9 Gene
Localization for HEATR9 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 2 |
| plasma membrane | 1 |
| nucleus | 1 |
| golgi apparatus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HEATR9 Gene
Pathways & Interactions for HEATR9 Gene
No Data Available
Interacting Proteins for HEATR9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002244 | hematopoietic progenitor cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HEATR9 Gene
Transcripts for HEATR9 Gene
mRNA/cDNA for HEATR9 Gene
- (7) REFSEQ mRNAs :
- (14) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HEATR9
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEATR9
- GenScript: Design CRISPR guide RNA sequences for HEATR9
miRNA Products
- Search ViGene Biosciences for HEATR9
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HEATR9
- Browse OriGene Inhibitory RNA Products For HEATR9
-
ViGene Biosciences ready-to-package AAV shRNAs for HEATR9 gene
Clone Products
-
OriGene ORF clones in human for HEATR9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HEATR9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for HEATR9 Gene
This gene is overexpressed in Testis (x35.4) and Whole Blood (x5.4).
This gene is overexpressed in Bone marrow stromal cell (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HEATR9 Gene
NURSA nuclear receptor signaling pathways regulating expression of HEATR9 Gene:
HEATR9Evidence on tissue expression from TISSUES for HEATR9 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for HEATR9
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HEATR9 Gene
Orthologs for HEATR9 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C17H17orf66 34 |
|
||
| cow (Bos Taurus) |
Mammalia | C19H17orf66 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Gm11435 34 |
|
||
| Heatr9 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | RGD1559875 34 |
|
- Species where no ortholog for HEATR9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HEATR9 Gene
No data available for Paralogs for HEATR9 Gene
Variants for HEATR9 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035685 | A breast cancer sample | ||||
| rs1000061814 | -- | 35,866,256(+) | CTCCC(C/T)GCTCC | intron-variant, upstream-variant-2KB | |
| rs1000478954 | -- | 35,858,319(+) | GCGGT(C/T)CTGAG | nc-transcript-variant, reference, missense | |
| rs1000560836 | -- | 35,868,823(+) | GAGGA(A/G)ACCTG | intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000672597 | -- | 35,864,659(+) | TCTGT(G/T)TTTCA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3640458 | CNV | loss | 21293372 |
| esv3892999 | CNV | loss | 25118596 |
| nsv1059795 | CNV | gain | 25217958 |
| nsv1079030 | OTHER | inversion | 25765185 |
| nsv960467 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.80;
66.92% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HEATR9 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HEATR9
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEATR9 Gene
Disorders for HEATR9 Gene
Relevant External Links for HEATR9
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HEATR9
No disorders were found for HEATR9 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HEATR9 Gene
Publications for HEATR9 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3 64
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
Products for HEATR9 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HEATR9
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HEATR9
- Search Origene for MassSpec and Protein Over-expression Lysates for HEATR9
- Origene Custom Protein Services for HEATR9
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HEATR9
- Browse OriGene Inhibitory RNA Products For HEATR9
- OriGene qPCR primer pairs for HEATR9
- OriGene CRISPR knockouts for HEATR9
- OriGene ORF clones in human for HEATR9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HEATR9
- GenScript: Next-day shipping cDNA ORF clone for HEATR9 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HEATR9
- GenScript Custom Assay Services for HEATR9
- GenScript Custom overexpressing Cell Line Services for HEATR9
- GenScript: Design CRISPR guide RNA sequences for HEATR9
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HEATR9
- Novus Biologicals proteins and lysates for HEATR9
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for HEATR9
- Abcam proteins for HEATR9
- Search for Assays for HEATR9 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- ViGene Biosciences adenoviral particle packaged cDNA for HEATR9 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HEATR9 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HEATR9 gene
- Search ViGene Biosciences for HEATR9
- Santa Cruz Biotechnology (SCBT) Antibodies for HEATR9
- Search Santa Cruz Biotechnology (SCBT) for HEATR9 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HEATR9
- Horizon Cell Lines for HEATR9
- Cyagen custom Knockout/knockin (KOKI) mouse models for HEATR9
- VectorBuilder custom plasmid, inducible vectors for HEATR9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HEATR9
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HEATR9 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer