HEATR6 Gene
protein-coding GIFtS: 46
GCID: GC17M058120
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|
HEAT repeat containing 6
| |
Aliases
for HEATR6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HEAT Repeat Containing 61 2 | | ABC11 2 3 | | Amplified In Breast Cancer Protein 12 3 | | FLJ220871 | | Amplified In Breast Cancer 12 | | HEAT Repeat-Containing Protein 62 |
Export aliases for HEATR6 gene to outside databasesPrevious GC identifers: GC17M055476 GC17M053492 |
Summaries
for HEATR6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HEAT6_HUMAN, Q6AI08Function: Amplification-dependent oncogene
|
Genomic Views
for HEATR6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HEATR6 gene promoter:
HOXA9 HOXA9B ISGF-3 Lmo2 STAT5A HOXA5 IRF-7A Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HEATR6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEATR6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q23.1 Ensembl cytogenetic band: 17q23.1 HGNC cytogenetic band: 17q23.2HEATR6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M058120: view genomic region
(about GC identifiers)
Start:
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58,120,552 bp from pter |
End:
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58,156,292 bp from pter |
Size:
|
35,741 bases |
Orientation:
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minus strand |
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Proteins
for HEATR6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HEAT6_HUMAN, Q6AI08 (See
protein sequence)Recommended Name: HEAT repeat-containing protein 6 Size: 1181 amino acids; 128781 Da
Miscellaneous: 17q23 region is one of the most commonly amplified regions in breast cancer and therefore may harborgenes important for breast cancer development and progression
Sequence caution: Sequence=AAL83912.1; Type=Erroneous initiation; Sequence=BAB15229.1; Type=Erroneous initiation;Sequence=BAB15348.1; Type=Erroneous initiation;
Secondary accessions: B3KXP3 Q6MZX1 Q6MZY2 Q8TDM9 Q9H6B3 Q9H6M7Explore the universe of human proteins at neXtProt for HEATR6: NX_Q6AI08
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6AI08
HEATR6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071353.4
ENSEMBL proteins: ENSP00000184956 ENSP00000464927 ENSP00000466192 ENSP00000465540 ENSP00000465986 ENSP00000465595 ENSP00000465429 ENSP00000468810 ENSP00000465817
Human Recombinant Protein Products for HEATR6:
HEATR6 Antibody Products:
Assay Products for HEATR6: |
Protein
Domains /
Families
for HEATR6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HEATR6 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6AI08ProtoNet protein and cluster: Q6AI08 UniProtKB/Swiss-Prot: HEAT6_HUMAN, Q6AI08Similarity: Contains 4 HEAT repeats |
Function
for HEATR6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: HEAT6_HUMAN, Q6AI08Function: Amplification-dependent oncogenePhenotypes:
1 GenomeRNAi human phenotype for HEATR6:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HEATR6 (NM_022070) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HEATR6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEATR6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEATR6 |
|
Pathways & Interactions
for HEATR6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HEATR6
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5 Interacting proteins for HEATR6 (Q6AI082, 3 ENSP000001849564) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for HEATR6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HEATR6
Search CenterWatch for drugs/clinical trials and news about HEATR6 / HEAT6
|
Transcripts
for HEATR6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HEATR6 gene: NM_022070.4 Unigene Cluster for HEATR6: HEAT repeat containing 6 Hs.591183 [show with all ESTs]Unigene Representative Sequence: BX64083111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000184956(uc010ddk.1 uc010wos.1 uc002iyk.1) ENST00000585976
ENST00000587003 ENST00000587314 ENST00000591683 ENST00000590587 ENST00000593228
ENST00000593097 ENST00000592664 ENST00000591074 ENST00000585712
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HEATR6 (NM_022070) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HEATR6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEATR6 |
Additional cDNA sequence: AF349752.1 AK025740.1 AK026070.1 AK127708.1 AK314655.1 BC119771.1 BC119813.1 BX640819.1 BX640831.1 CR627418.1 5 DOTS entries: DT.412773 DT.95357181 DT.100647616 DT.120923685 DT.205482 24/117 AceView cDNA sequences (see all 117): AI382890 BU187337 AA133790 AI561172 AI342465 AI497780 BM713511 CA843310 AA910077 AI672470 AI290042 BX102066 AI085791 Z38816 BM709661 BC040714 AA670100 BM547348 BF223187 BI258798 BU624591 BU957457 CB305526 AI979200
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for HEATR6 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · |
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| SP1: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19b | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b |
|---|
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for HEATR6
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Expression
for HEATR6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HEATR6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCAGGGTTG
About this image
See HEATR6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HEATR6
SOURCE GeneReport for Unigene cluster: Hs.591183
UniProtKB/Swiss-Prot: HEAT6_HUMAN, Q6AI08Tissue specificity: Amplified in breast cancer cell lines MCF-7 and BT-474
SABiosciences Custom PCR Arrays for HEATR6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEATR6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HEATR6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEATR6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEATR6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEATR6 |
Orthologs
for HEATR6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HEATR6 gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for HEATR6 (if available)
TreeFam Gene Tree for HEATR6 (if available) |
Paralogs
for HEATR6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HEATR6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HEATR6 (58120552 - 58156292 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for HEATR6
3 CNVs: 0805 102496 4044
2 Inversions: 37195 37196 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEATR6 |
|
Disorders
/ Diseases
for HEATR6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HEATR6 for disorders About GeneDecksing
1  disease for HEATR6: About MalaCardsbreast cancer
1 disease from the University of Copenhagen DISEASES database for HEATR6:Breast cancer Export disorders for HEATR6 gene to outside databases
|
Publications
for HEATR6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HEATR6 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with HEATR6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The 17q23 amplicon and breast cancer. (PubMed id 12755490)1, 3 Sinclair C.S....Couch F.J. (2003)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
|
External Searches for HEATR6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HEATR6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HEATR6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HEATR6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HEATR6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HEATR6 gene:
Search GeneIP for patents involving HEATR6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HEATR6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HEATR6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEATR6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEATR6 | | | OriGene Protein Over-expression Lysate for HEATR6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HEATR6 | | OriGene 3'-UTR Clone for HEATR6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HEATR6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HEATR6 | | OriGene Custom Protein Services for HEATR6 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HEATR6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEATR6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEATR6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEATR6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEATR6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEATR6 |
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 | | | HEATR6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEATR6 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEATR6 |
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