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Aliases for HEATR6 Gene

Aliases for HEATR6 Gene

  • HEAT Repeat Containing 6 2 3
  • Amplified In Breast Cancer Protein 1 3 4
  • Amplified In Breast Cancer 1 2 3
  • ABC1 3 4

External Ids for HEATR6 Gene

Previous GeneCards Identifiers for HEATR6 Gene

  • GC17M055476
  • GC17M058120
  • GC17M053492

Summaries for HEATR6 Gene

GeneCards Summary for HEATR6 Gene

HEATR6 (HEAT Repeat Containing 6) is a Protein Coding gene. Diseases associated with HEATR6 include breast cancer. GO annotations related to this gene include poly(A) RNA binding and binding.

UniProtKB/Swiss-Prot for HEATR6 Gene

  • Amplification-dependent oncogene

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEATR6 Gene

Genomics for HEATR6 Gene

Regulatory Elements for HEATR6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HEATR6 Gene

Chromosome:
17
Start:
60,043,191 bp from pter
End:
60,078,931 bp from pter
Size:
35,741 bases
Orientation:
Minus strand

Genomic View for HEATR6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HEATR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEATR6 Gene

Proteins for HEATR6 Gene

  • Protein details for HEATR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6AI08-HEAT6_HUMAN
    Recommended name:
    HEAT repeat-containing protein 6
    Protein Accession:
    Q6AI08
    Secondary Accessions:
    • B3KXP3
    • Q6MZX1
    • Q6MZY2
    • Q8TDM9
    • Q9H6B3
    • Q9H6M7

    Protein attributes for HEATR6 Gene

    Size:
    1181 amino acids
    Molecular mass:
    128781 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • 17q23 region is one of the most commonly amplified regions in breast cancer and therefore may harbor genes important for breast cancer development and progression
    SequenceCaution:
    • Sequence=AAL83912.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15229.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15348.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HEATR6 Gene

Proteomics data for HEATR6 Gene at MOPED

Post-translational modifications for HEATR6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for HEATR6

No data available for DME Specific Peptides for HEATR6 Gene

Domains & Families for HEATR6 Gene

Protein Domains for HEATR6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HEATR6 Gene

Graphical View of Domain Structure for InterPro Entry

Q6AI08

UniProtKB/Swiss-Prot:

HEAT6_HUMAN :
  • Contains 4 HEAT repeats.
Similarity:
  • Contains 4 HEAT repeats.
genes like me logo Genes that share domains with HEATR6: view

No data available for Gene Families for HEATR6 Gene

Function for HEATR6 Gene

Molecular function for HEATR6 Gene

UniProtKB/Swiss-Prot Function:
Amplification-dependent oncogene

Gene Ontology (GO) - Molecular Function for HEATR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with HEATR6: view
genes like me logo Genes that share phenotypes with HEATR6: view

Animal Model Products

CRISPR Products

miRNA for HEATR6 Gene

miRTarBase miRNAs that target HEATR6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEATR6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HEATR6 Gene

Localization for HEATR6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEATR6 Gene COMPARTMENTS Subcellular localization image for HEATR6 gene
Compartment Confidence
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HEATR6 Gene

Pathways & Interactions for HEATR6 Gene

SuperPathways for HEATR6 Gene

No Data Available

Interacting Proteins for HEATR6 Gene

Gene Ontology (GO) - Biological Process for HEATR6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HEATR6 Gene

Drugs & Compounds for HEATR6 Gene

No Compound Related Data Available

Transcripts for HEATR6 Gene

Unigene Clusters for HEATR6 Gene

HEAT repeat containing 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEATR6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HEATR6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5:
SP6: - -
SP7:
SP8: - - - - - - - - - - - - - - -

ExUns: 19b ^ 20 ^ 21a · 21b ^ 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for HEATR6 Gene

GeneLoc Exon Structure for
HEATR6
ECgene alternative splicing isoforms for
HEATR6

Expression for HEATR6 Gene

mRNA expression in normal human tissues for HEATR6 Gene

Protein differential expression in normal tissues from HIPED for HEATR6 Gene

This gene is overexpressed in Bone (51.0) and Breast (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HEATR6 Gene



SOURCE GeneReport for Unigene cluster for HEATR6 Gene Hs.591183

mRNA Expression by UniProt/SwissProt for HEATR6 Gene

Q6AI08-HEAT6_HUMAN
Tissue specificity: Amplified in breast cancer cell lines MCF-7 and BT-474.
genes like me logo Genes that share expression patterns with HEATR6: view

Protein tissue co-expression partners for HEATR6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HEATR6 Gene

Orthologs for HEATR6 Gene

This gene was present in the common ancestor of animals.

Orthologs for HEATR6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HEATR6 35
  • 87.3 (n)
  • 87.13 (a)
HEATR6 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HEATR6 35
  • 88.37 (n)
  • 88.62 (a)
HEATR6 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Heatr6 35
  • 82.73 (n)
  • 83.57 (a)
Heatr6 16
Heatr6 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HEATR6 35
  • 99.32 (n)
  • 99.07 (a)
HEATR6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Heatr6 35
  • 83.14 (n)
  • 83.56 (a)
oppossum
(Monodelphis domestica)
Mammalia HEATR6 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HEATR6 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves HEATR6 35
  • 73.11 (n)
  • 73.85 (a)
HEATR6 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HEATR6 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487263 35
  • 65.72 (n)
  • 67.05 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53988 35
zebrafish
(Danio rerio)
Actinopterygii zgc:172359 35
  • 59.34 (n)
  • 56.85 (a)
HEATR6 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007509 35
fruit fly
(Drosophila melanogaster)
Insecta CG16989 35
  • 43.96 (n)
  • 34.98 (a)
CG16989 36
  • 28 (a)
OneToOne
Species with no ortholog for HEATR6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HEATR6 Gene

ENSEMBL:
Gene Tree for HEATR6 (if available)
TreeFam:
Gene Tree for HEATR6 (if available)

Paralogs for HEATR6 Gene

genes like me logo Genes that share paralogs with HEATR6: view

No data available for Paralogs for HEATR6 Gene

Variants for HEATR6 Gene

Sequence variations from dbSNP and Humsavar for HEATR6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs345198 -- 60,072,623(-) TCCCT(C/T)CTAGG intron-variant
rs370539 -- 60,056,080(-) tcctt(C/T)tcttc intron-variant
rs740646 -- 60,064,829(-) GATGT(C/T)TATAT intron-variant
rs956326 -- 60,065,799(-) GCTTA(A/G)AAAAA intron-variant
rs2302201 -- 60,050,716(-) TTGAG(A/T)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HEATR6 Gene

Variant ID Type Subtype PubMed ID
nsv471702 CNV Gain 15918152
nsv833502 CNV Gain 17160897
dgv996e1 CNV Complex 17122850
nsv428348 CNV Gain 18775914
nsv7295 OTHER Inversion 18451855
nsv499622 OTHER Inversion 21111241
esv2653138 CNV Deletion 19546169
nsv833504 CNV Gain 17160897

Variation tolerance for HEATR6 Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.12; 80.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HEATR6 Gene

HapMap Linkage Disequilibrium report
HEATR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEATR6 Gene

Disorders for HEATR6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HEATR6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association

Relevant External Links for HEATR6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HEATR6
genes like me logo Genes that share disorders with HEATR6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HEATR6 Gene

Publications for HEATR6 Gene

  1. The 17q23 amplicon and breast cancer. (PMID: 12755490) Sinclair C.S. … Couch F.J. (Breast Cancer Res. Treat. 2003) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 67

Products for HEATR6 Gene

Sources for HEATR6 Gene

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