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Aliases for HEATR5B Gene

Aliases for HEATR5B Gene

  • HEAT Repeat Containing 5B 2 3
  • KIAA1414 4

External Ids for HEATR5B Gene

Summaries for HEATR5B Gene

GeneCards Summary for HEATR5B Gene

HEATR5B (HEAT Repeat Containing 5B) is a Protein Coding gene. An important paralog of this gene is HEATR5A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEATR5B Gene

Genomics for HEATR5B Gene

Genomic Location for HEATR5B Gene

Start:
36,968,383 bp from pter
End:
37,084,345 bp from pter
Size:
115,963 bases
Orientation:
Minus strand

Genomic View for HEATR5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HEATR5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEATR5B Gene

Regulatory Elements for HEATR5B Gene

Proteins for HEATR5B Gene

  • Protein details for HEATR5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2D3-HTR5B_HUMAN
    Recommended name:
    HEAT repeat-containing protein 5B
    Protein Accession:
    Q9P2D3
    Secondary Accessions:
    • B5MDU8
    • Q7Z3B2
    • Q9NVL7

    Protein attributes for HEATR5B Gene

    Size:
    2071 amino acids
    Molecular mass:
    224302 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91733.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HEATR5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HEATR5B Gene

Proteomics data for HEATR5B Gene at MOPED

Post-translational modifications for HEATR5B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys1829

Other Protein References for HEATR5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HEATR5B Gene

Domains for HEATR5B Gene

Protein Domains for HEATR5B Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

HTR5B_HUMAN
Family:
  • Belongs to the HEATR5 family.:
    • Q9P2D3
Similarity:
  • Contains 3 HEAT repeats.:
    • Q9P2D3
genes like me logo Genes that share domains with HEATR5B: view

No data available for Gene Families for HEATR5B Gene

Function for HEATR5B Gene

Gene Ontology (GO) - Molecular Function for HEATR5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with HEATR5B: view

Phenotypes for HEATR5B Gene

GenomeRNAi human phenotypes for HEATR5B:
genes like me logo Genes that share phenotypes with HEATR5B: view

miRNA for HEATR5B Gene

miRTarBase miRNAs that target HEATR5B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HEATR5B Gene

Localization for HEATR5B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEATR5B Gene COMPARTMENTS Subcellular localization image for HEATR5B gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HEATR5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HEATR5B: view

Pathways for HEATR5B Gene

SuperPathways for HEATR5B Gene

No Data Available

Interacting Proteins for HEATR5B Gene

Gene Ontology (GO) - Biological Process for HEATR5B Gene

None

No data available for Pathways by source for HEATR5B Gene

Transcripts for HEATR5B Gene

Unigene Clusters for HEATR5B Gene

HEAT repeat containing 5B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HEATR5B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36a · 36b ^ 37
SP1: -
SP2: -
SP3: -
SP4: - -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for HEATR5B Gene

GeneLoc Exon Structure for
HEATR5B
ECgene alternative splicing isoforms for
HEATR5B

Expression for HEATR5B Gene

mRNA expression in normal human tissues for HEATR5B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HEATR5B Gene

SOURCE GeneReport for Unigene cluster for HEATR5B Gene Hs.744084

genes like me logo Genes that share expressions with HEATR5B: view

Orthologs for HEATR5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HEATR5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HEATR5B 36
  • 99.47 (n)
  • 99.95 (a)
HEATR5B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HEATR5B 37
  • 97 (a)
OneToOne
LOC540503 36
  • 92.51 (n)
  • 97.39 (a)
dog
(Canis familiaris)
Mammalia HEATR5B 36
  • 92.58 (n)
  • 97.63 (a)
HEATR5B 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Heatr5b 36
  • 86.97 (n)
  • 95.89 (a)
Heatr5b 16
Heatr5b 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HEATR5B 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HEATR5B 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Heatr5b 36
  • 86.56 (n)
  • 95.67 (a)
chicken
(Gallus gallus)
Aves HEATR5B 36
  • 81.26 (n)
  • 93.14 (a)
HEATR5B 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HEATR5B 37
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19754 36
tropical clawed frog
(Silurana tropicalis)
Amphibia heatr5b 36
  • 75.98 (n)
  • 88.44 (a)
Str.14 36
zebrafish
(Danio rerio)
Actinopterygii CABZ01061567.1 37
  • 64 (a)
OneToMany
heatr5b 36
  • 71.47 (n)
  • 86.47 (a)
HEATR5B (1 of 2) 37
  • 85 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002215 36
  • 53.04 (n)
  • 54.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2747 36
  • 53.49 (n)
  • 52.81 (a)
CG2747 37
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C13F10.4 36
  • 48.25 (n)
  • 40.07 (a)
C13F10.4 37
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAA1 37
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToMany
Species with no ortholog for HEATR5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HEATR5B Gene

ENSEMBL:
Gene Tree for HEATR5B (if available)
TreeFam:
Gene Tree for HEATR5B (if available)

Paralogs for HEATR5B Gene

Paralogs for HEATR5B Gene

Selected SIMAP similar genes for HEATR5B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HEATR5B: view

Variants for HEATR5B Gene

Sequence variations from dbSNP and Humsavar for HEATR5B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs868465 -- 37,067,691(+) aattt(A/G)aacct intron-variant
rs1007823 -- 37,003,585(+) GCTCT(A/C/G/T)ACTAT reference, synonymous-codon
rs1008838 -- 37,025,092(-) AAATG(C/T)GCTAT intron-variant
rs1008839 -- 37,025,053(-) TTCAT(C/T)TTCCT intron-variant
rs1105014 -- 37,038,584(+) TTATC(C/G)TCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HEATR5B Gene

Variant ID Type Subtype PubMed ID
nsv428395 CNV Gain 18775914
nsv456363 CNV Gain 19166990
nsv873879 CNV Loss 21882294
esv2719926 CNV Deletion 23290073
esv2719927 CNV Deletion 23290073
esv2719928 CNV Deletion 23290073
esv2719930 CNV Deletion 23290073

Relevant External Links for HEATR5B Gene

HapMap Linkage Disequilibrium report
HEATR5B

Disorders for HEATR5B Gene

Relevant External Links for HEATR5B

Genetic Association Database (GAD)
HEATR5B
Human Genome Epidemiology (HuGE) Navigator
HEATR5B
genes like me logo Genes that share disorders with HEATR5B: view

No data available for UniProtKB/Swiss-Prot for HEATR5B Gene

Publications for HEATR5B Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 49
  4. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 49
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for HEATR5B Gene

Sources for HEATR5B Gene

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