HEATR5B Gene
protein-coding GIFtS: 43
GCID: GC02M037195
|
|
HEAT repeat containing 5B
| |
Aliases
for HEATR5B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HEAT Repeat Containing 5B1 2 | | KIAA14141 3 | | DKFZp686P151841 | | HEAT Repeat-Containing Protein 5B2 |
Export aliases for HEATR5B gene to outside databasesPrevious GC identifers: GC02M037061 GC02M036949 |
Summaries
for HEATR5B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HEATR5B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HEATR5B gene promoter:
HOXA9B HOXA9 FOXO3 Ik-3 Egr-4 Meis-1b GATA-2 HSF2 IRF-7A Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HEATR5B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEATR5B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p22.2 Ensembl cytogenetic band: 2p22.2 HGNC cytogenetic band: 2p22.2HEATR5B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M037195: view genomic region
(about GC identifiers)
Start:
|
37,195,526 bp from pter |
End:
|
37,311,485 bp from pter |
Size:
|
115,960 bases |
Orientation:
|
minus strand |
|
Proteins
for HEATR5B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HTR5B_HUMAN, Q9P2D3 (See
protein sequence)Recommended Name: HEAT repeat-containing protein 5B Size: 2071 amino acids; 224302 Da
Sequence caution: Sequence=BAA91733.1; Type=Erroneous initiation;
Secondary accessions: B5MDU8 Q7Z3B2 Q9NVL7Alternative splicing: 3 isoforms: Q9P2D3-1 Q9P2D3-2 Q9P2D3-3 Explore the universe of human proteins at neXtProt for HEATR5B: NX_Q9P2D3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P2D3
HEATR5B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061897.1
ENSEMBL proteins: ENSP00000408222 ENSP00000233099 ENSP00000346531
Human Recombinant Protein Products:
HEATR5B Antibody Products:
Assay Products for HEATR5B: |
Protein
Domains /
Families
for HEATR5B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HEATR5B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P2D3ProtoNet protein and cluster: Q9P2D3 1 Blocks protein family: IPB000357 HEAT repeat
UniProtKB/Swiss-Prot: HTR5B_HUMAN, Q9P2D3Similarity: Belongs to the HEATR5 familySimilarity: Contains 3 HEAT repeats |
Function
for HEATR5B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR5B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR5B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HEATR5B (NM_019024) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HEATR5B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEATR5B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEATR5B |
1 GenomeRNAi human phenotype for HEATR5B:
|
Pathways & Interactions
for HEATR5B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HEATR5B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for HEATR5B (ENSP000002330994) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for HEATR5B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HEATR5B
Search CenterWatch for drugs/clinical trials and news about HEATR5B / HTR5B
|
Transcripts
for HEATR5B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HEATR5B gene: NM_019024.1 Unigene Cluster for HEATR5B: HEAT repeat containing 5B Hs.744084 [show with all ESTs]Unigene Representative Sequence: NM_0190246 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000425467 ENST00000233099(uc002rpp.1) ENST00000471051(uc002rpq.4)
ENST00000467978 ENST00000478810 ENST00000354531(uc010ezy.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR5B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR5B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HEATR5B (NM_019024) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HEATR5B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEATR5B |
Additional cDNA sequence: AB037835.1 AK001513.1 AK022179.1 AK026928.1 AK093937.1 AK096637.1 AL832880.1 BC031035.1 BC085607.1 BC150605.1 BX538008.1 BX648805.1 12 DOTS entries: DT.95090339 DT.92427288 DT.445133 DT.99927813 DT.99934593 DT.100738250 DT.92005225 DT.91841263 DT.95325766 DT.75148173 DT.75163930 DT.99966318 24/134 AceView cDNA sequences (see all 134): AB037835 AL832880 CR618236 BX280418 BQ086364 CD654038 BM474864 F09207 F11545 AK026928 AW338205 CA432330 AA236640 Z45504 AA779076 BQ101046 C18350 BX503920 AI432311 N39252 AW752588 Z41197 AW847728 F11546
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for HEATR5B (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33a | · | 33b | ^ | 34 | ^ | 35 | ^ | 36a | · | 36b | ^ | 37 |
|---|
|
| SP1: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HEATR5B
|
Expression
for HEATR5B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HEATR5B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HEATR5B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HEATR5B
SOURCE GeneReport for Unigene cluster: Hs.744084
SABiosciences Custom PCR Arrays for HEATR5B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEATR5B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HEATR5B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEATR5B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEATR5B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEATR5B |
Orthologs
for HEATR5B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HEATR5B gene from 8/27 species (see all 27) About this table
ENSEMBL Gene Tree for HEATR5B (if available)
TreeFam Gene Tree for HEATR5B (if available) |
Paralogs
for HEATR5B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HEATR5B gene
- HEATR5A2
1 SIMAP similar gene for HEATR5B using alignment to 3 protein entries: HTR5B_HUMAN (see all proteins):HEATR5A
HEATR5B for paralogs About GeneDecksing
|
Genomic Variants
for HEATR5B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HEATR5B (37195526 - 37311485 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HEATR5B: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for HEATR5B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 HEATR5B for disorders About MalaCards
HEATR5B for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: HEATR5B (3 documents)
Export disorders for HEATR5B gene to outside databases
|
Publications
for HEATR5B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HEATR5B gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with HEATR5B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Common variants in 22 loci are associated with QRS du ration and cardiac ventricular conduction. (PubMed id 21076409)1 Sotoodehnia N....Arking D.E. (2010)
- Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1 Luke M.M....Psaty B.M. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
|
External Searches for HEATR5B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HEATR5B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HEATR5B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing HEATR5B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HEATR5B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HEATR5B gene:
Search GeneIP for patents involving HEATR5B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HEATR5B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HEATR5B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEATR5B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEATR5B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HEATR5B | | OriGene 3'-UTR Clone for HEATR5B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR5B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR5B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HEATR5B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEATR5B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEATR5B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEATR5B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEATR5B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEATR5B |
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 |  |  |  | |
| | | | Search Tocris compounds for HEATR5B |
| |  |  |  |  | | | | |
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 | | | HEATR5B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEATR5B |
|  |  |  | | | | Search ThermoFisher Antibodies for HEATR5B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEATR5B |
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