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HEATR5B Gene

protein-coding   GIFtS: 46
GCID: GC02M037195

HEAT Repeat Containing 5B

  Search for HEATR5B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HEAT Repeat Containing 5B1 2
HEAT Repeat-Containing Protein 5B2
KIAA14143

External Ids:    HGNC: 292731   Entrez Gene: 544972   Ensembl: ENSG000000088697   UniProtKB: Q9P2D33   

Export aliases for HEATR5B gene to outside databases

Previous GC identifers: GC02M037061 GC02M036949


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HEATR5B Gene:
HEATR5B (HEAT repeat containing 5B) is a protein-coding gene. An important paralog of this gene is HEATR5A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HEATR5B gene promoter:
         HOXA9B   HOXA9   FOXO3   Ik-3   Egr-4   Meis-1b   GATA-2   HSF2   IRF-7A   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHEATR5B promoter sequence
   Search Chromatin IP Primers for HEATR5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HEATR5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.2   Ensembl cytogenetic band:  2p22.2   HGNC cytogenetic band: 2p22.2

HEATR5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HEATR5B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M037195:  view genomic region     (about GC identifiers)

Start:
37,195,526 bp from pter      End:
37,311,485 bp from pter
Size:
115,960 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HTR5B_HUMAN, Q9P2D3 (See protein sequence)
Recommended Name: HEAT repeat-containing protein 5B  
Size: 2071 amino acids; 224302 Da
Sequence caution: Sequence=BAA91733.1; Type=Erroneous initiation;
Secondary accessions: B5MDU8 Q7Z3B2 Q9NVL7
Alternative splicing: 3 isoforms:  Q9P2D3-1   Q9P2D3-2   Q9P2D3-3   

Explore the universe of human proteins at neXtProt for HEATR5B: NX_Q9P2D3

Explore proteomics data for HEATR5B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1829
  • Modification sites at PhosphoSitePlus

  • See HEATR5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061897.1  
    ENSEMBL proteins: 
     ENSP00000408222   ENSP00000233099   ENSP00000346531  

    HEATR5B Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for HEATR5B
    Search eBioscience for ELISAs for HEATR5B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9P2D3

    ProtoNet protein and cluster: Q9P2D3

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: HTR5B_HUMAN, Q9P2D3
    Similarity: Belongs to the HEATR5 family
    Similarity: Contains 3 HEAT repeats


    Find genes that share domains with HEATR5B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with HEATR5B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HEATR5B:
     Decreased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HEATR5B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HEATR5B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HEATR5B

    miRNA
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    miRTarBase miRNAs that target HEATR5B:
    hsa-mir-335-5p (MIRT017793), hsa-mir-140-3p (MIRT021676)

    Block miRNA regulation of human, mouse, rat HEATR5B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HEATR5B:
    hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidHEATR5B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HEATR5B
    Predesigned siRNA for gene silencing in human, mouse, rat HEATR5B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEATR5B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HEATR5B
    Interactions:

        Search GeneGlobe Interaction Network for HEATR5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for HEATR5B (ENSP000002330994) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP1G1ENSP000003771484STRING: ENSP00000377148
    PTPN11ENSP000003409444STRING: ENSP00000340944
    AP4B1ENSP000002566584STRING: ENSP00000256658
    SMARCB1ENSP000002631214STRING: ENSP00000263121
    CLTCENSP000002691224STRING: ENSP00000269122
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HEATR5B (HTR5B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HEATR5B gene: 
    NM_019024.1  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425467 ENST00000233099(uc002rpp.1) ENST00000471051(uc002rpq.4)
    ENST00000467978 ENST00000478810 ENST00000354531(uc010ezy.1)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate HEATR5B:
    hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidHEATR5B 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HEATR5B
    Predesigned siRNA for gene silencing in human, mouse, rat HEATR5B
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    OriGene ORF clones in mouse, rat for HEATR5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HEATR5B (NM_019024)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEATR5B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HEATR5B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HEATR5B
      QuantiTect SYBR Green Assays in human, mouse, rat HEATR5B
      QuantiFast Probe-based Assays in human, mouse, rat HEATR5B

    Selected AceView cDNA sequences (see all 134):

    AB037835 AW847728 BM474864 AI432311 AK096637 BX503920 AA779076 BQ101046 
    C18350 AL832880 AW338205 CD654038 F09206 F11545 AA236640 F09207 
    Z41197 CA432330 CR618236 Z45504 AK026928 N39252 AW752588 BX280418 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HEATR5B (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                            -                                         -                     
    SP2:                                                                                            -                                         -                     
    SP3:                                                                                                                                      -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36a · 36b ^ 37
    SP1:  -                                                                                                               
    SP2:  -                                                                                                               
    SP3:  -                                                                                                               
    SP4:                                                                          -     -                                 
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for HEATR5B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HEATR5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HEATR5B Expression
    About this image

    HEATR5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HEATR5B Protein Expression
        Custom PCR Arrays for HEATR5B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEATR5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HEATR5B gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Heatr5b1 , 5 HEAT repeat containing 5B1, 5 86.97(n)1
    95.89(a)1
      17 (49.54 cM)5
    3204731  NM_001081179.11  NP_001074648.11 
     787529065 
    chicken
    (Gallus gallus)
    Aves HEATR5B1 HEAT repeat containing 5B 81.26(n)
    93.14(a)
      421469  XM_419518.4  XP_419518.2 
    lizard
    (Anolis carolinensis)
    Reptilia HEATR5B6
    HEAT repeat containing 5B
    90(a)
    1 ↔ 1
    1(232599124-232656645)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.197542 Xenopus laevis transcribed sequence with weak similarity more 79.7(n)    BG486892.1 
    zebrafish
    (Danio rerio)
    Actinopterygii heatr5b1 HEAT repeat containing 5B 71.47(n)
    86.47(a)
      571772  XM_001920861.3  XP_001920896.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG27471 CG2747 53.49(n)
    52.81(a)
      40950  NM_001275434.1  NP_001262363.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C13F10.41 C13F10.4 48.25(n)
    40.07(a)
      179109  NM_072427.4  NP_504828.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LAA16
    AP-1 accessory protein; colocalizes with clathrin ...
    16(a)
    1 → many
    X(41389-47433) YJL207C


    ENSEMBL Gene Tree for HEATR5B (if available)
    TreeFam Gene Tree for HEATR5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HEATR5B gene
    HEATR5A2  
    1 SIMAP similar gene for HEATR5B using alignment to 3 protein entries:     HTR5B_HUMAN (see all proteins):
    HEATR5A

    Find genes that share paralogs with HEATR5B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HEATR5B (see all 2293)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30807951,2
    C--37104424(+) CAAAC-/TCAACAT 1 -- int10--------
    rs751932671,2
    F--37207692(+) GACTTG/ACTTTT 1 -- ds50011Minor allele frequency- A:0.10WA 118
    rs1855315251,2
    --37207796(+) TATTTC/TGTACG 1 -- ds50010--------
    rs1453612611,2
    --37207800(+) TCGTAC/TGGTAA 1 -- ds50010--------
    rs1904567111,2
    --37207801(+) CGTACA/GGTAAA 1 -- ds50010--------
    rs1814490401,2
    --37207815(+) CCCACC/TACATG 1 -- ds50010--------
    rs1154434481,2
    F--37207910(+) TTCAAT/CAAATA 1 -- ds50011Minor allele frequency- C:0.01NA 120
    rs793261091,2
    F--37208293(+) CCCATT/ATTTTT 1 -- ut311Minor allele frequency- A:0.01EA 120
    rs1859858151,2
    --37208324(+) CTGCCC/TGACTA 1 -- ut310--------
    rs1900561861,2
    --37208404(+) CAAAAC/GAGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HEATR5B (37195526 - 37311485 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HEATR5B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719928CNV Deletion23290073
    esv2719926CNV Deletion23290073
    esv2719930CNV Deletion23290073
    esv2719927CNV Deletion23290073
    nsv873879CNV Loss21882294
    nsv456363CNV Gain19166990
    nsv428395CNV Gain18775914

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HEATR5B
    DNA2.0 Custom Variant and Variant Library Synthesis for HEATR5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with HEATR5B           About GenesLikeMe

    Genetic Association Database (GAD): HEATR5B
    Human Genome Epidemiology (HuGE) Navigator: HEATR5B (3 documents)

    Export disorders for HEATR5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HEATR5B gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with HEATR5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. (PubMed id 21076409)1, 4 Sotoodehnia N....Arking D.E. (Nat. Genet. 2010)
    4. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54497 HGNC: 29273 AceView: KIAA1414 Ensembl:ENSG00000008869 euGenes: HUgn54497
    ECgene: HEATR5B H-InvDB: HEATR5B

    (According to HUGE)
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    HUGE: KIAA1414

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HEATR5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HEATR5B gene:
    Search GeneIP for patents involving HEATR5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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