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Aliases for HEATR5B Gene

Aliases for HEATR5B Gene

  • HEAT Repeat Containing 5B 2 3
  • KIAA1414 4

External Ids for HEATR5B Gene

Previous GeneCards Identifiers for HEATR5B Gene

  • GC02M037061
  • GC02M037195

Summaries for HEATR5B Gene

GeneCards Summary for HEATR5B Gene

HEATR5B (HEAT Repeat Containing 5B) is a Protein Coding gene. An important paralog of this gene is HEATR5A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEATR5B Gene

Genomics for HEATR5B Gene

Regulatory Elements for HEATR5B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HEATR5B Gene

36,968,383 bp from pter
37,084,345 bp from pter
115,963 bases
Minus strand

Genomic View for HEATR5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HEATR5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEATR5B Gene

Proteins for HEATR5B Gene

  • Protein details for HEATR5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    HEAT repeat-containing protein 5B
    Protein Accession:
    Secondary Accessions:
    • B5MDU8
    • Q7Z3B2
    • Q9NVL7

    Protein attributes for HEATR5B Gene

    2071 amino acids
    Molecular mass:
    224302 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91733.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HEATR5B Gene


neXtProt entry for HEATR5B Gene

Proteomics data for HEATR5B Gene at MOPED

Post-translational modifications for HEATR5B Gene

  • Ubiquitination at Lys1829
  • Modification sites at PhosphoSitePlus

Other Protein References for HEATR5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HEATR5B Gene

Domains for HEATR5B Gene

Protein Domains for HEATR5B Gene


Suggested Antigen Peptide Sequences for HEATR5B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HEATR5 family.
  • Contains 3 HEAT repeats.
  • Belongs to the HEATR5 family.
  • Contains 3 HEAT repeats.
genes like me logo Genes that share domains with HEATR5B: view

No data available for Gene Families for HEATR5B Gene

Function for HEATR5B Gene

Gene Ontology (GO) - Molecular Function for HEATR5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with HEATR5B: view

Phenotypes for HEATR5B Gene

GenomeRNAi human phenotypes for HEATR5B:
genes like me logo Genes that share phenotypes with HEATR5B: view

Animal Model Products

CRISPR Products

miRNA for HEATR5B Gene

miRTarBase miRNAs that target HEATR5B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEATR5B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HEATR5B Gene

Localization for HEATR5B Gene

Subcellular locations from

Jensen Localization Image for HEATR5B Gene COMPARTMENTS Subcellular localization image for HEATR5B gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HEATR5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HEATR5B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HEATR5B Gene

Pathways for HEATR5B Gene

SuperPathways for HEATR5B Gene

No Data Available

Interacting Proteins for HEATR5B Gene

Gene Ontology (GO) - Biological Process for HEATR5B Gene


No data available for Pathways by source for HEATR5B Gene

Transcripts for HEATR5B Gene

Unigene Clusters for HEATR5B Gene

HEAT repeat containing 5B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEATR5B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HEATR5B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^
SP1: - -
SP2: - -
SP3: -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36a · 36b ^ 37
SP1: -
SP2: -
SP3: -
SP4: - -

Relevant External Links for HEATR5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HEATR5B Gene

mRNA expression in normal human tissues for HEATR5B Gene

Protein differential expression in normal tissues for HEATR5B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.1), Adipocyte (8.9), and Lymph node (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HEATR5B Gene

SOURCE GeneReport for Unigene cluster for HEATR5B Gene Hs.744084

genes like me logo Genes that share expressions with HEATR5B: view

Expression partners for HEATR5B Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HEATR5B Gene

Orthologs for HEATR5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HEATR5B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC540503 35
  • 92.51 (n)
  • 97.39 (a)
  • 97 (a)
(Canis familiaris)
Mammalia HEATR5B 35
  • 92.58 (n)
  • 97.63 (a)
  • 98 (a)
(Mus musculus)
Mammalia Heatr5b 35
  • 86.97 (n)
  • 95.89 (a)
Heatr5b 16
Heatr5b 36
  • 96 (a)
(Pan troglodytes)
Mammalia HEATR5B 35
  • 99.47 (n)
  • 99.95 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Heatr5b 35
  • 86.56 (n)
  • 95.67 (a)
(Monodelphis domestica)
Mammalia HEATR5B 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia HEATR5B 36
  • 91 (a)
(Gallus gallus)
Aves HEATR5B 35
  • 81.26 (n)
  • 93.14 (a)
  • 93 (a)
(Anolis carolinensis)
Reptilia HEATR5B 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia heatr5b 35
  • 75.98 (n)
  • 88.44 (a)
Str.14 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19754 35
(Danio rerio)
Actinopterygii heatr5b 35
  • 71.47 (n)
  • 86.47 (a)
CABZ01061567.1 36
  • 64 (a)
HEATR5B (1 of 2) 36
  • 85 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002215 35
  • 53.04 (n)
  • 54.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2747 35
  • 53.49 (n)
  • 52.81 (a)
CG2747 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea C13F10.4 35
  • 48.25 (n)
  • 40.07 (a)
C13F10.4 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAA1 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for HEATR5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HEATR5B Gene

Gene Tree for HEATR5B (if available)
Gene Tree for HEATR5B (if available)

Paralogs for HEATR5B Gene

Paralogs for HEATR5B Gene

(1) SIMAP similar genes for HEATR5B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HEATR5B: view

Variants for HEATR5B Gene

Sequence variations from dbSNP and Humsavar for HEATR5B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs868465 -- 37,067,691(+) aattt(A/G)aacct intron-variant
rs1007823 -- 37,003,585(+) GCTCT(A/C/G/T)ACTAT reference, synonymous-codon
rs1008838 -- 37,025,092(-) AAATG(C/T)GCTAT intron-variant
rs1008839 -- 37,025,053(-) TTCAT(C/T)TTCCT intron-variant
rs1123648 -- 37,005,187(-) CATGA(A/G)AGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HEATR5B Gene

Variant ID Type Subtype PubMed ID
nsv428395 CNV Gain 18775914
nsv456363 CNV Gain 19166990
nsv873879 CNV Loss 21882294
esv2719926 CNV Deletion 23290073
esv2719927 CNV Deletion 23290073
esv2719928 CNV Deletion 23290073
esv2719930 CNV Deletion 23290073

Relevant External Links for HEATR5B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEATR5B Gene

Disorders for HEATR5B Gene

Relevant External Links for HEATR5B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for HEATR5B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HEATR5B Gene

Publications for HEATR5B Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 48
  4. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for HEATR5B Gene

Sources for HEATR5B Gene

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