Aliases for HEATR5A Gene
Aliases for HEATR5A Gene
External Ids for HEATR5A Gene
- HGNC: 20276
- Entrez Gene: 25938
- Ensembl: ENSG00000129493
- UniProtKB: Q86XA9
Previous HGNC Symbols for HEATR5A Gene
- C14orf125
Previous GeneCards Identifiers for HEATR5A Gene
- GC14M030833
- GC14M031760
- GC14M011878
Summaries for HEATR5A Gene
GeneCards Summary for HEATR5A Gene
HEATR5A (HEAT Repeat Containing 5A) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is HEATR5B.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEATR5A Gene
Genomics for HEATR5A Gene
Regulatory Elements for HEATR5A Gene
Enhancers for HEATR5A Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HEATR5A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HEATR5A Gene
- Chromosome:
- 14
- Start:
- 31,291,788 bp from pter
- End:
- 31,420,582 bp from pter
- Size:
- 128,795 bases
- Orientation:
- Minus strand
Genomic View for HEATR5A Gene
Genes around HEATR5A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q12 by Ensembl
- 14q12 by Entrez Gene
- 14q12 by HGNC
HEATR5A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HEATR5A Gene
Proteins for HEATR5A Gene
-
Protein details for HEATR5A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86XA9-HTR5A_HUMAN
- Recommended name:
- HEAT repeat-containing protein 5A
- Protein Accession:
- Q86XA9
- Q68DD8
- Q6P3S5
- Q6P5R9
- Q9H8D7
- Q9NXB7
- Q9P2N0
- Q9UFQ3
Protein attributes for HEATR5A Gene
- Size:
- 2040 amino acids
- Molecular mass:
- 222004 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA91098.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for HEATR5A Gene
Post-translational modifications for HEATR5A Gene
Other Protein References for HEATR5A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HEATR5A
- Invitrogen Antibodies for HEATR5A
- Search GeneTex for Antibodies for HEATR5A
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HEATR5A
- Origene Custom Protein Services for HEATR5A
- Novus Biologicals proteins for HEATR5A
- Search GeneTex for Proteins for HEATR5A
Assay Products
No data available for DME Specific Peptides for HEATR5A Gene
Domains & Families for HEATR5A Gene
Protein Domains for HEATR5A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HEATR5A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86XA9- Family:
-
- Belongs to the HEATR5 family.
No data available for Gene Families for HEATR5A Gene
Function for HEATR5A Gene
Phenotypes for HEATR5A Gene
- GenomeRNAi human phenotypes for HEATR5A:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HEATR5A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HEATR5A gene
- Search ViGene Biosciences for HEATR5A
CRISPR Products
-
OriGene CRISPR knockouts for HEATR5A
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEATR5A
miRNA for HEATR5A Gene
- miRTarBase miRNAs that target HEATR5A
-
- hsa-mir-124-3p (MIRT022304)
- hsa-mir-153-5p (MIRT233157)
- hsa-mir-1250-3p (MIRT233162)
- hsa-mir-1303 (MIRT703007)
- hsa-mir-5096 (MIRT703008)
- hsa-mir-6848-3p (MIRT703009)
- hsa-mir-6843-3p (MIRT703010)
- hsa-mir-5587-5p (MIRT703011)
- hsa-mir-197-3p (MIRT703012)
- hsa-mir-411-5p (MIRT703013)
- hsa-mir-6832-5p (MIRT703014)
- hsa-mir-6801-5p (MIRT703015)
- hsa-mir-193b-5p (MIRT703016)
- hsa-mir-6131 (MIRT703017)
- hsa-mir-3663-5p (MIRT703018)
- hsa-mir-372-5p (MIRT703019)
- hsa-mir-371a-5p (MIRT703020)
- hsa-mir-616-5p (MIRT703021)
- hsa-mir-373-5p (MIRT703022)
- hsa-mir-371b-5p (MIRT703023)
- hsa-mir-4716-5p (MIRT703024)
- hsa-mir-484 (MIRT703025)
- hsa-mir-3155b (MIRT703026)
- hsa-mir-3155a (MIRT703027)
- hsa-mir-4781-3p (MIRT703028)
- hsa-mir-483-5p (MIRT703029)
- hsa-mir-620 (MIRT721813)
- hsa-mir-1270 (MIRT721814)
- hsa-mir-4531 (MIRT721815)
- hsa-mir-519e-5p (MIRT721816)
- hsa-mir-515-5p (MIRT721817)
- hsa-mir-432-5p (MIRT721818)
- hsa-mir-4778-3p (MIRT721819)
- hsa-mir-5695 (MIRT721820)
- hsa-mir-519d-5p (MIRT721821)
- hsa-mir-141-5p (MIRT721822)
miRNA Products
- Search ViGene Biosciences for HEATR5A
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HEATR5A
- Browse OriGene Inhibitory RNA Products For HEATR5A
-
ViGene Biosciences ready-to-package AAV shRNAs for HEATR5A gene
Cell Line Products
-
Horizon Cell Lines for HEATR5A
-
ViGene Biosciences adenoviral particle packaged cDNA for HEATR5A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HEATR5A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HEATR5A gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HEATR5A Gene
Localization for HEATR5A Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| peroxisome | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HEATR5A Gene
Pathways & Interactions for HEATR5A Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for HEATR5A Gene
Transcripts for HEATR5A Gene
mRNA/cDNA for HEATR5A Gene
- (1) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (79) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HEATR5A Gene
CRISPR Products
-
OriGene CRISPR knockouts for HEATR5A
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEATR5A
miRNA Products
- Search ViGene Biosciences for HEATR5A
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HEATR5A
- Browse OriGene Inhibitory RNA Products For HEATR5A
-
ViGene Biosciences ready-to-package AAV shRNAs for HEATR5A gene
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · | 18c | ^ | 19 | ^ | 20 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | ^ | 27a | · | 27b | ^ | 28a | · | 28b | · | 28c | ^ | 29 | ^ | 30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||
| SP8: |
Expression for HEATR5A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
This gene is overexpressed in Testis (32.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HEATR5A Gene
NURSA nuclear receptor signaling pathways regulating expression of HEATR5A Gene:
HEATR5ASOURCE GeneReport for Unigene cluster for HEATR5A Gene:
Hs.744979Primer Products
-
OriGene qPCR primer pairs for HEATR5A
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HEATR5A Gene
Orthologs for HEATR5A Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HEATR5A 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HEATR5A 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HEATR5A 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Heatr5a 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Heatr5a 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HEATR5A 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HEATR5A 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HEATR5A 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HEATR5A 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | heatr5a 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | heatr5a 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG2747 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | C13F10.4 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | LAA1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HEATR5A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HEATR5A Gene
(1) SIMAP similar genes for HEATR5A Gene using alignment to 9 proteins:
Variants for HEATR5A Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004204 | -- | 31,390,146(+) | GATGC(C/T)AGGTG | intron-variant | |
| rs1000010828 | -- | 31,305,317(+) | GAGTG(C/T)AATGG | intron-variant | |
| rs1000034357 | -- | 31,396,427(+) | TGACA(A/G)AGCCA | intron-variant | |
| rs1000045138 | -- | 31,354,930(+) | ATTTA(A/T)CACAA | intron-variant | |
| rs1000071081 | -- | 31,304,180(+) | CTCCG(A/G)CCTAG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1064n106 | CNV | deletion | 24896259 |
| esv1624128 | CNV | deletion | 17803354 |
| esv2241940 | CNV | deletion | 18987734 |
| esv2491965 | CNV | deletion | 19546169 |
| esv2664691 | CNV | deletion | 23128226 |
| esv2748558 | CNV | deletion | 23290073 |
| esv2748559 | CNV | deletion | 23290073 |
| esv3181106 | CNV | deletion | 24192839 |
| esv33189 | CNV | loss | 17666407 |
| esv3551323 | CNV | deletion | 23714750 |
| esv3551324 | CNV | deletion | 23714750 |
| esv3615 | CNV | loss | 18987735 |
| esv3633966 | CNV | loss | 21293372 |
| esv991558 | CNV | deletion | 20482838 |
| nsv1134364 | CNV | deletion | 24896259 |
| nsv1138285 | CNV | deletion | 24896259 |
| nsv1138286 | CNV | deletion | 24896259 |
| nsv1148157 | CNV | deletion | 26484159 |
| nsv499776 | OTHER | inversion | 21111241 |
| nsv7250 | OTHER | inversion | 18451855 |
| nsv84542 | CNV | deletion | 16902084 |
| nsv958738 | CNV | deletion | 24416366 |
| nsv974471 | CNV | duplication | 23825009 |
| nsv983811 | CNV | duplication | 23825009 |
Gene Damage Index Score:
13.40;
95.43% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HEATR5A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HEATR5A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEATR5A Gene
Disorders for HEATR5A Gene
Relevant External Links for HEATR5A
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HEATR5A
No disorders were found for HEATR5A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HEATR5A Gene
Publications for HEATR5A Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
Products for HEATR5A Gene
- Browse R&D Systems for Antibodies
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- OriGene qPCR primer pairs for HEATR5A
- OriGene CRISPR knockouts for HEATR5A
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- Novus Biologicals Antibodies for HEATR5A
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for HEATR5A gene
- ViGene Biosciences lentiviral particle packaged cDNA for HEATR5A gene
- ViGene Biosciences ready-to-package AAV shRNAs for HEATR5A gene
- Search ViGene Biosciences for HEATR5A
- Horizon Cell Lines for HEATR5A
- Cyagen custom Knockout/knockin (KOKI) mouse models for HEATR5A
- VectorBuilder custom plasmid, inducible vectors for HEATR5A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HEATR5A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HEATR5A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
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- (127) Disease Ontology
- (128) Genetics Home Reference
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- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer