Aliases for HEATR4 Gene
External Ids for HEATR4 Gene
- HGNC: 16761
- Entrez Gene: 399671
- Ensembl: ENSG00000187105
- UniProtKB: Q86WZ0
Previous GeneCards Identifiers for HEATR4 Gene
- GC14M073015
- GC14M073946
- GC14M054111
Summaries for HEATR4 Gene
GeneCards Summary for HEATR4 Gene
HEATR4 (HEAT Repeat Containing 4) is a Protein Coding gene. GO annotations related to this gene include binding.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEATR4 Gene
Genomics for HEATR4 Gene
Regulatory Elements for HEATR4 Gene
Enhancers for HEATR4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HEATR4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HEATR4 Gene
- Chromosome:
- 14
- Start:
- 73,478,484 bp from pter
- End:
- 73,558,947 bp from pter
- Size:
- 80,464 bases
- Orientation:
- Minus strand
Genomic View for HEATR4 Gene
Genes around HEATR4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q24.3 by Ensembl
- 14q24.3 by Entrez Gene
- 14q24.3 by HGNC
HEATR4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HEATR4 Gene
Proteins for HEATR4 Gene
-
Protein details for HEATR4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86WZ0-HEAT4_HUMAN
- Recommended name:
- HEAT repeat-containing protein 4
- Protein Accession:
- Q86WZ0
- B7Z7V9
- E9KL41
Protein attributes for HEATR4 Gene
- Size:
- 1026 amino acids
- Molecular mass:
- 117175 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH47590.1; Type=Erroneous termination; Positions=39; Note=Translated as Glu.; Evidence={ECO:0000305};
Protein Expression for HEATR4 Gene
Post-translational modifications for HEATR4 Gene
Other Protein References for HEATR4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HEATR4
- Novus Biologicals Antibodies for HEATR4
-
Abcam antibodies for HEATR4
- Invitrogen Antibodies for HEATR4
- GeneTex HEATR4 antibody for HEATR4
Protein Products
-
OriGene Purified Proteins for HEATR4
- Search Origene for MassSpec and Protein Over-expression Lysates for HEATR4
- Origene Custom Protein Services for HEATR4
- Novus Biologicals proteins for HEATR4
- Search GeneTex for Proteins for HEATR4
Assay Products
No data available for DME Specific Peptides for HEATR4 Gene
Domains & Families for HEATR4 Gene
Protein Domains for HEATR4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HEATR4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for HEATR4 Gene
Function for HEATR4 Gene
Phenotypes for HEATR4 Gene
- GenomeRNAi human phenotypes for HEATR4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HEATR4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HEATR4 gene
- Search ViGene Biosciences for HEATR4
CRISPR Products
-
OriGene CRISPR knockouts for HEATR4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEATR4
- GenScript: Design CRISPR guide RNA sequences for HEATR4
miRNA Products
- Search ViGene Biosciences for HEATR4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HEATR4
- Browse OriGene Inhibitory RNA Products For HEATR4
-
ViGene Biosciences ready-to-package AAV shRNAs for HEATR4 gene
Cell Line Products
-
Horizon Cell Lines for HEATR4
-
ViGene Biosciences adenoviral particle packaged cDNA for HEATR4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HEATR4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HEATR4 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HEATR4 Gene
Localization for HEATR4 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| mitochondrion | 1 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HEATR4 Gene
Pathways & Interactions for HEATR4 Gene
No data available for Pathways by source and SIGNOR curated interactions for HEATR4 Gene
Transcripts for HEATR4 Gene
mRNA/cDNA for HEATR4 Gene
- (6) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (21) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HEATR4 Gene
- HEAT repeat containing 4:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for HEATR4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEATR4
- GenScript: Design CRISPR guide RNA sequences for HEATR4
miRNA Products
- Search ViGene Biosciences for HEATR4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HEATR4
- Browse OriGene Inhibitory RNA Products For HEATR4
-
ViGene Biosciences ready-to-package AAV shRNAs for HEATR4 gene
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - |
| ExUns: | 20 | ^ | 21 |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: |
Expression for HEATR4 Gene
mRNA differential expression in normal tissues according to GTEx for HEATR4 Gene
This gene is overexpressed in Testis (x10.4).
This gene is overexpressed in Adipocyte (60.4) and Heart (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HEATR4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HEATR4 Gene:
HEATR4SOURCE GeneReport for Unigene cluster for HEATR4 Gene:
Hs.660774Primer Products
-
OriGene qPCR primer pairs for HEATR4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HEATR4 Gene
Orthologs for HEATR4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HEATR4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HEATR4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HEATR4 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | RGD1566220 34 |
|
||
| mouse (Mus musculus) |
Mammalia | LOC101055670 34 |
|
||
| Gm17673 35 |
|
OneToOne | |||
| Heatr4 16 |
|
|
|||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | HEATR4 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HEATR4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | heatr4 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC796278 34 |
|
||
| HEATR4 35 |
|
OneToOne | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| CSA.7366 35 |
|
OneToMany |
- Species where no ortholog for HEATR4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HEATR4 Gene
No data available for Paralogs for HEATR4 Gene
Variants for HEATR4 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1057519450 | Pathogenic | 73,537,831(+) | GCGCG(-/AGCCGGTGCGCGCG)GGCCG | intron-variant, reference, frameshift-variant | |
| rs1000028636 | -- | 73,517,976(+) | AGCTA(C/T)TCGTG | intron-variant | |
| rs1000042399 | -- | 73,496,632(+) | CTTGG(C/T)TTCCT | intron-variant, reference, missense | |
| rs1000117038 | -- | 73,602,837(+) | TACCT(C/T)TCTTT | intron-variant | |
| rs1000119696 | -- | 73,631,579(+) | AAGGG(C/T)ATGCT | intron-variant |
Residual Variation Intolerance Score:
90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.86;
74.04% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HEATR4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HEATR4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEATR4 Gene
Disorders for HEATR4 Gene
Relevant External Links for HEATR4
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HEATR4
No disorders were found for HEATR4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HEATR4 Gene
Publications for HEATR4 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 2 3 4 64
- Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J. … Liu Y. (Mol. Cell. Proteomics 2010) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3 64
- Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
Products for HEATR4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Culture Products
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- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HEATR4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HEATR4
- Search Origene for MassSpec and Protein Over-expression Lysates for HEATR4
- Origene Custom Protein Services for HEATR4
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HEATR4
- Browse OriGene Inhibitory RNA Products For HEATR4
- OriGene qPCR primer pairs for HEATR4
- OriGene CRISPR knockouts for HEATR4
- OriGene ORF clones in human for HEATR4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for HEATR4 in any vector
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- GenScript Custom overexpressing Cell Line Services for HEATR4
- GenScript: Design CRISPR guide RNA sequences for HEATR4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for HEATR4
- Novus Biologicals proteins for HEATR4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for HEATR4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HEATR4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HEATR4 gene
- Search ViGene Biosciences for HEATR4
- Horizon Cell Lines for HEATR4
- Cyagen custom Knockout/knockin (KOKI) mouse models for HEATR4
- VectorBuilder custom plasmid, inducible vectors for HEATR4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HEATR4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HEATR4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
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- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
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- (92) Vector BioLabs
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- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (122) diseasecard
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer