HEATR4 Gene
protein-coding GIFtS: 41
GCID: GC14M073946
|
|
HEAT repeat containing 4
| |
Aliases
for HEATR4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HEAT Repeat Containing 41 2 | | MGC485951 | | HEAT Repeat-Containing Protein 42 |
Export aliases for HEATR4 gene to outside databasesPrevious GC identifers: GC14M073015 GC14M054111 |
Summaries
for HEATR4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HEATR4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HEATR4 gene promoter:
GR STAT5B AML1a Pax-5 FOXD1 Arnt AREB6 HFH-1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for HEATR4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEATR4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3HEATR4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M073946: view genomic region
(about GC identifiers)
Start:
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73,945,189 bp from pter |
End:
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74,025,651 bp from pter |
Size:
|
80,463 bases |
Orientation:
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minus strand |
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Proteins
for HEATR4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HEAT4_HUMAN, Q86WZ0 (See
protein sequence)Recommended Name: HEAT repeat-containing protein 4 Size: 1026 amino acids; 117175 Da
Sequence caution: Sequence=AAH47590.1; Type=Erroneous termination; Positions=39; Note=Translated as Glu;
Secondary accessions: B7Z7V9 E9KL41Explore the universe of human proteins at neXtProt for HEATR4: NX_Q86WZ0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86WZ0
HEATR4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001207413.1 NP_976054.2
ENSEMBL proteins: ENSP00000450444 ENSP00000335447 ENSP00000452407 ENSP00000451367 ENSP00000456792 ENSP00000453597
Human Recombinant Protein Products:
HEATR4 Antibody Products:
Assay Products for HEATR4: |
Protein
Domains /
Families
for HEATR4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HEATR4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86WZ0ProtoNet protein and cluster: Q86WZ0 1 Blocks protein family: IPB000357 HEAT repeat
UniProtKB/Swiss-Prot: HEAT4_HUMAN, Q86WZ0Similarity: Contains 3 HEAT repeats |
Function
for HEATR4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HEATR4 (NM_203309) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HEATR4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEATR4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEATR4 |
|
Pathways & Interactions
for HEATR4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HEATR4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for HEATR4 (Q86WZ03 ENSP000003354474) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for HEATR4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HEATR4
Search CenterWatch for drugs/clinical trials and news about HEATR4 / HEAT4
|
Transcripts
for HEATR4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HEATR4 gene (2 alternative transcripts): NM_001220484.1 NM_203309.2 Unigene Cluster for HEATR4: HEAT repeat containing 4 Hs.660774 [show with all ESTs]Unigene Representative Sequence: NM_0012204848 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000565094 ENST00000553558(uc010tub.1 uc021rwe.1) ENST00000334988(uc021rwf.1)
ENST00000566478 ENST00000556455 ENST00000557603 ENST00000563329 ENST00000560393
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HEATR4 (NM_203309) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HEATR4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEATR4 |
Additional cDNA sequence: AK093515.1 AK302564.1 BC047590.1 GU727638.1 6 DOTS entries: DT.100746813 DT.97834940 DT.120758251 DT.120758425 DT.408891 DT.75200026 21 AceView cDNA sequences: BE674505 BF447872 AL704027 AX748177 AK093515 AA100496 CD243990 CD358661 AW341239 NM_203309 BC047590 AW291522 AI796246 BQ376264 BG772808 AW449497 AW444473 BQ375952 BF985317 BX375913 BQ953182
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for HEATR4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 | ^ | 21 |
|---|
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| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for HEATR4
|
Expression
for HEATR4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HEATR4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HEATR4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HEATR4
SOURCE GeneReport for Unigene cluster: Hs.660774
SABiosciences Custom PCR Arrays for HEATR4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEATR4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HEATR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEATR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEATR4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEATR4 |
Orthologs
for HEATR4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HEATR4 gene from 2/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
HEATR46 |
-- |
41(a) |
1 ↔ 1 |
1(39185378-39202164) |
zebrafish
(Danio rerio) |
Actinopterygii |
CT027705.36 |
-- |
42(a) |
1 ↔ 1 |
17(31655998-31664237) |
Species with no ortholog for HEATR4
ENSEMBL Gene Tree for HEATR4 (if available)
TreeFam Gene Tree for HEATR4 (if available) |
Paralogs
for HEATR4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HEATR4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HEATR4 (73945189 - 74025651 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 30 variations for HEATR4
15/29 CNVs (see all 29): 71917 76672 37822 35265 23304 7039 71916 87267 3942 35269 101979 101980 87266 58686 31973
1 Indel: 33273 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEATR4 |
|
Disorders
/ Diseases
for HEATR4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HEATR4 for disorders About GeneDecksing
1  disease for HEATR4: About MalaCardsepididymitis
Export disorders for HEATR4 gene to outside databases
|
Publications
for HEATR4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HEATR4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HEATR4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2, 3 Gerhard D.S....Malek J. (2004)
- Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for HEATR4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HEATR4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HEATR4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HEATR4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HEATR4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HEATR4 gene:
Search GeneIP for patents involving HEATR4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HEATR4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEATR4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEATR4 | | | OriGene Protein Over-expression Lysate for HEATR4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HEATR4 | | OriGene 3'-UTR Clone for HEATR4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEATR4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HEATR4 | | OriGene Custom Protein Services for HEATR4 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HEATR4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEATR4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEATR4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEATR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEATR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEATR4 |
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| | | | Search Tocris compounds for HEATR4 |
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 | | | HEATR4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEATR4 |
|  |  |  | | | | Search ThermoFisher Antibodies for HEATR4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEATR4 |
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