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Aliases for HEATR4 Gene

Aliases for HEATR4 Gene

  • HEAT Repeat Containing 4 2 3

External Ids for HEATR4 Gene

Previous GeneCards Identifiers for HEATR4 Gene

  • GC14M073015
  • GC14M073946
  • GC14M054111

Summaries for HEATR4 Gene

GeneCards Summary for HEATR4 Gene

HEATR4 (HEAT Repeat Containing 4) is a Protein Coding gene. GO annotations related to this gene include binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEATR4 Gene

Genomics for HEATR4 Gene

Regulatory Elements for HEATR4 Gene

Genomic Location for HEATR4 Gene

73,478,484 bp from pter
73,558,947 bp from pter
80,464 bases
Minus strand

Genomic View for HEATR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HEATR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEATR4 Gene

Proteins for HEATR4 Gene

  • Protein details for HEATR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    HEAT repeat-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B7Z7V9
    • E9KL41

    Protein attributes for HEATR4 Gene

    1026 amino acids
    Molecular mass:
    117175 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH47590.1; Type=Erroneous termination; Positions=39; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for HEATR4 Gene

Proteomics data for HEATR4 Gene at MOPED

Post-translational modifications for HEATR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HEATR4 Gene

No data available for DME Specific Peptides for HEATR4 Gene

Domains & Families for HEATR4 Gene

Protein Domains for HEATR4 Gene


Suggested Antigen Peptide Sequences for HEATR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 HEAT repeats.
  • Contains 3 HEAT repeats.
genes like me logo Genes that share domains with HEATR4: view

No data available for Gene Families for HEATR4 Gene

Function for HEATR4 Gene

Gene Ontology (GO) - Molecular Function for HEATR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with HEATR4: view

Phenotypes for HEATR4 Gene

genes like me logo Genes that share phenotypes with HEATR4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEATR4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HEATR4 Gene

Localization for HEATR4 Gene

Subcellular locations from

Jensen Localization Image for HEATR4 Gene COMPARTMENTS Subcellular localization image for HEATR4 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HEATR4 Gene

Pathways & Interactions for HEATR4 Gene

SuperPathways for HEATR4 Gene

No Data Available

Interacting Proteins for HEATR4 Gene

Selected Interacting proteins: Q86WZ0-HEAT4_HUMAN for HEATR4 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for HEATR4 Gene


No data available for Pathways by source and SIGNOR curated interactions for HEATR4 Gene

Drugs & Compounds for HEATR4 Gene

No Compound Related Data Available

Transcripts for HEATR4 Gene

Unigene Clusters for HEATR4 Gene

HEAT repeat containing 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEATR4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HEATR4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - - -

ExUns: 20 ^ 21

Relevant External Links for HEATR4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HEATR4 Gene

mRNA expression in normal human tissues for HEATR4 Gene

mRNA differential expression in normal tissues according to GTEx for HEATR4 Gene

This gene is overexpressed in Testis (x10.4).

Protein differential expression in normal tissues from HIPED for HEATR4 Gene

This gene is overexpressed in Adipocyte (60.4) and Heart (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HEATR4 Gene

SOURCE GeneReport for Unigene cluster for HEATR4 Gene Hs.660774

genes like me logo Genes that share expression patterns with HEATR4: view

Protein tissue co-expression partners for HEATR4 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HEATR4 Gene

Orthologs for HEATR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HEATR4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HEATR4 35
  • 83.9 (n)
  • 76.36 (a)
  • 76 (a)
(Canis familiaris)
Mammalia HEATR4 35
  • 83.74 (n)
  • 77.42 (a)
  • 76 (a)
(Mus musculus)
Mammalia LOC101055670 35
  • 73.58 (n)
  • 64.34 (a)
Gm17673 36
  • 64 (a)
(Pan troglodytes)
Mammalia HEATR4 35
  • 99.12 (n)
  • 98.73 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1566220 35
  • 74.17 (n)
  • 65.33 (a)
(Monodelphis domestica)
Mammalia HEATR4 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
-- 36
  • 41 (a)
(Anolis carolinensis)
Reptilia HEATR4 36
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia heatr4 35
  • 50.99 (n)
  • 39.68 (a)
(Danio rerio)
Actinopterygii LOC796278 35
  • 52.64 (n)
  • 43.23 (a)
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
CSA.7366 36
  • 20 (a)
Species with no ortholog for HEATR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HEATR4 Gene

Gene Tree for HEATR4 (if available)
Gene Tree for HEATR4 (if available)

Paralogs for HEATR4 Gene

No data available for Paralogs for HEATR4 Gene

Variants for HEATR4 Gene

Sequence variations from dbSNP and Humsavar for HEATR4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1968089 -- 73,545,826(-) CAGCC(C/T)GAATT intron-variant
rs2007313 -- 73,557,969(-) AGGCA(C/T)AGtcc intron-variant
rs2019553 -- 73,557,932(-) agatc(A/G)cttga intron-variant
rs2019554 -- 73,557,970(-) CAGGC(A/G)tagtc intron-variant
rs2019555 -- 73,557,985(-) TACCC(A/G)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HEATR4 Gene

Variant ID Type Subtype PubMed ID
dgv1958n71 CNV Gain 21882294
nsv510643 CNV Loss 20534489
esv2665379 CNV Deletion 23128226
dgv400e199 CNV Deletion 23128226
esv2748865 CNV Deletion 23290073
esv2748866 CNV Deletion 23290073
dgv641e1 CNV Complex 17122850
nsv428295 CNV Gain 18775914
nsv832828 CNV Gain+Loss 17160897
nsv9152 CNV Gain+Loss 18304495
esv2561778 CNV Deletion 19546169
nsv1349 CNV Insertion 18451855
nsv1350 CNV Loss 18451855
nsv9153 CNV Gain+Loss 18304495
nsv821106 CNV Deletion 20802225
nsv826976 CNV Loss 20364138
esv29080 CNV Gain+Loss 19812545
esv1006342 CNV Deletion 20482838
nsv514745 CNV Complex 21397061
dgv401e199 CNV Deletion 23128226
nsv819138 CNV Loss 19587683
dgv21n47 CNV Loss 21111241
esv2748867 CNV Deletion 23290073
nsv514746 CNV Complex 21397061
esv2518446 CNV Loss 19546169
esv2421969 OTHER Complex 20811451
nsv902088 CNV Gain 21882294
nsv442687 CNV CNV 18776908
dgv374n67 CNV Loss 20364138
nsv826978 CNV Loss 20364138
nsv826979 CNV Loss 20364138
esv990289 CNV Loss 20482838
esv29945 CNV Loss 18421352
esv33155 CNV Gain+Loss 17666407
nsv826981 CNV Loss 20364138
nsv514747 CNV Complex 21397061
nsv482172 CNV Gain 20164927
dgv375n67 CNV Loss 20364138
nsv436178 CNV Deletion 17901297
esv2672436 CNV Deletion 23128226
nsv514748 CNV Complex 21397061
nsv514749 CNV Complex 21397061
nsv826985 CNV Loss 20364138
esv30006 CNV Gain 17803354
nsv826987 CNV Loss 20364138
nsv514750 CNV Complex 21397061

Variation tolerance for HEATR4 Gene

Residual Variation Intolerance Score: 90.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.86; 74.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HEATR4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEATR4 Gene

Disorders for HEATR4 Gene

Relevant External Links for HEATR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HEATR4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HEATR4 Gene

Publications for HEATR4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 2 67
  2. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 67
  3. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J. … Liu Y. (Mol. Cell. Proteomics 2010) 67
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for HEATR4 Gene

Sources for HEATR4 Gene

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