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Aliases for HEATR3 Gene

Aliases for HEATR3 Gene

  • HEAT Repeat Containing 3 2 3
  • SYO1 3 6
  • HEAT Repeat-Containing Protein 3 3

External Ids for HEATR3 Gene

Summaries for HEATR3 Gene

GeneCards Summary for HEATR3 Gene

HEATR3 (HEAT Repeat Containing 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEATR3 Gene

Genomics for HEATR3 Gene

Genomic Location for HEATR3 Gene

Start:
50,065,941 bp from pter
End:
50,106,387 bp from pter
Size:
40,447 bases
Orientation:
Plus strand

Genomic View for HEATR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HEATR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEATR3 Gene

Regulatory Elements for HEATR3 Gene

Proteins for HEATR3 Gene

  • Protein details for HEATR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4Q2-HEAT3_HUMAN
    Recommended name:
    HEAT repeat-containing protein 3
    Protein Accession:
    Q7Z4Q2
    Secondary Accessions:
    • A8K1N4
    • Q8N525
    • Q8WV56
    • Q96CC9
    • Q9NWN7

    Protein attributes for HEATR3 Gene

    Size:
    680 amino acids
    Molecular mass:
    74583 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14415.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HEATR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HEATR3 Gene

Proteomics data for HEATR3 Gene at MOPED

Post-translational modifications for HEATR3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys631

Other Protein References for HEATR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HEATR3 Gene

Domains for HEATR3 Gene

Protein Domains for HEATR3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

HEAT3_HUMAN
Similarity:
  • Contains 2 HEAT repeats.:
    • Q7Z4Q2
genes like me logo Genes that share domains with HEATR3: view

No data available for Gene Families for HEATR3 Gene

Function for HEATR3 Gene

Gene Ontology (GO) - Molecular Function for HEATR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with HEATR3: view

Phenotypes for HEATR3 Gene

GenomeRNAi human phenotypes for HEATR3:
genes like me logo Genes that share phenotypes with HEATR3: view

miRNA for HEATR3 Gene

miRTarBase miRNAs that target HEATR3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HEATR3 Gene

Localization for HEATR3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEATR3 Gene COMPARTMENTS Subcellular localization image for HEATR3 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for HEATR3 Gene

Pathways for HEATR3 Gene

SuperPathways for HEATR3 Gene

No Data Available

Interacting Proteins for HEATR3 Gene

Gene Ontology (GO) - Biological Process for HEATR3 Gene

None

No data available for Pathways by source for HEATR3 Gene

Transcripts for HEATR3 Gene

Unigene Clusters for HEATR3 Gene

HEAT repeat containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HEATR3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5: -
SP6: - - -
SP7: - - -
SP8:

Relevant External Links for HEATR3 Gene

GeneLoc Exon Structure for
HEATR3
ECgene alternative splicing isoforms for
HEATR3

Expression for HEATR3 Gene

mRNA expression in normal human tissues for HEATR3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HEATR3 Gene

SOURCE GeneReport for Unigene cluster for HEATR3 Gene Hs.733027

genes like me logo Genes that share expressions with HEATR3: view

Orthologs for HEATR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HEATR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HEATR3 36
  • 99.66 (n)
  • 99.85 (a)
HEATR3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HEATR3 36
  • 89.35 (n)
  • 89.84 (a)
HEATR3 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HEATR3 36
  • 90.39 (n)
  • 91.32 (a)
HEATR3 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Heatr3 36
  • 84.29 (n)
  • 86.3 (a)
Heatr3 16
Heatr3 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HEATR3 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HEATR3 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Heatr3 36
  • 84.36 (n)
  • 86.62 (a)
chicken
(Gallus gallus)
Aves HEATR3 36
  • 72.17 (n)
  • 68.6 (a)
HEATR3 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HEATR3 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia heatr3 36
  • 63.48 (n)
  • 58.59 (a)
Str.15308 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4214 36
zebrafish
(Danio rerio)
Actinopterygii heatr3 36
  • 57.65 (n)
  • 54.26 (a)
heatr3 37
  • 52 (a)
OneToOne
zgc77793 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010051 36
  • 43.7 (n)
  • 30.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10286 36
  • 40.49 (n)
  • 28.29 (a)
CG10286 37
  • 26 (a)
OneToOne
Species with no ortholog for HEATR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HEATR3 Gene

ENSEMBL:
Gene Tree for HEATR3 (if available)
TreeFam:
Gene Tree for HEATR3 (if available)

Paralogs for HEATR3 Gene

No data available for Paralogs for HEATR3 Gene

Variants for HEATR3 Gene

Sequence variations from dbSNP and Humsavar for HEATR3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs877639 -- 50,084,334(+) GGAAA(A/G)GCTTA intron-variant
rs1008815 -- 50,068,309(+) TTATT(G/T)TATTT intron-variant, upstream-variant-2KB
rs1477127 -- 50,091,472(-) attat(G/T)ttttt intron-variant
rs1547478 -- 50,067,104(-) AGCAA(G/T)GGGAT intron-variant
rs1861662 -- 50,073,472(-) CAAGA(A/G)AAACA intron-variant

Relevant External Links for HEATR3 Gene

HapMap Linkage Disequilibrium report
HEATR3
Human Gene Mutation Database (HGMD)
HEATR3

No data available for Structural Variations from Database of Genomic Variants (DGV) for HEATR3 Gene

Disorders for HEATR3 Gene

No disorders were found for HEATR3 Gene.

No data available for UniProtKB/Swiss-Prot for HEATR3 Gene

Publications for HEATR3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. System-wide changes to SUMO modifications in response to heat shock. (PMID: 19471022) Golebiowski F. … Hay R.T. (Sci Signal 2009) 3

Products for HEATR3 Gene

Sources for HEATR3 Gene

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