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HEATR2 Gene

protein-coding   GIFtS: 50
GCID: GC07P000766

HEAT Repeat Containing 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HEAT Repeat Containing 21 2
CILD182 5
HEAT Repeat-Containing Protein 22

External Ids:    HGNC: 260131   Entrez Gene: 549192   Ensembl: ENSG000001648187   OMIM: 6148645   UniProtKB: Q86Y563   

Export aliases for HEATR2 gene to outside databases

Previous GC identifer: GC07P000732


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HEATR2 Gene:
The protein encoded by this gene is essential for the preassembly or stability of axonemal dynein arms, and is
found only in organisms with motile cilia and flagella. Mutations in this gene are associated with primary
ciliary dyskinesia-18, a disorder characterized by abnormalities of motile cilia. Alternatively spliced
transcript variants have been found for this gene. (provided by RefSeq, Feb 2013)

GeneCards Summary for HEATR2 Gene:
HEATR2 (HEAT repeat containing 2) is a protein-coding gene. Diseases associated with HEATR2 include primary ciliary dyskinesia18: heatr2-related primary ciliary dyskinesia, and ciliary dyskinesia, primary, 18.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the HEATR2 gene promoter:
         Pax-5   Egr-1   HSF1 (long)   Egr-4   Arnt   CREB   deltaCREB   HSF1short   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 9): HEATR2 promoter sequence
   Search Chromatin IP Primers for HEATR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HEATR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22.3

HEATR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HEATR2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P000766:  view genomic region     (about GC identifiers)

Start:
766,338 bp from pter      End:
829,190 bp from pter
Size:
62,853 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 827,519-884,476     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HEAT2_HUMAN, Q86Y56 (See protein sequence)
Recommended Name: HEAT repeat-containing protein 2  
Size: 855 amino acids; 93521 Da
Sequence caution: Sequence=AAH10850.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q69YL1 Q96FI9 Q9NX75
Alternative splicing: 3 isoforms:  Q86Y56-1   Q86Y56-2   Q86Y56-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HEATR2: NX_Q86Y56

Explore proteomics data for HEATR2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys43, Lys655
  • Modification sites at PhosphoSitePlus

  • See HEATR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060272.3  
    ENSEMBL proteins: 
     ENSP00000297440   ENSP00000410788   ENSP00000403165   ENSP00000384884   ENSP00000321451  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR021133 HEAT_type_2
     IPR000357 HEAT
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q86Y56

    ProtoNet protein and cluster: Q86Y56

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: HEAT2_HUMAN, Q86Y56
    Similarity: Contains 10 HEAT repeats


    HEATR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    HEATR2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for HEATR2:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased S DNA content  Increased cell size 

    Animal Models:
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HEATR2

    miRNA
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    miRTarBase miRNAs that target HEATR2:
    hsa-mir-615-3p (MIRT040032), hsa-mir-16-5p (MIRT031418), hsa-let-7b-5p (MIRT032214), hsa-mir-30a-5p (MIRT028437), hsa-mir-155-5p (MIRT020505), hsa-mir-31-5p (MIRT049865), hsa-mir-92b-3p (MIRT040582), hsa-mir-1 (MIRT023507), hsa-mir-1301-3p (MIRT035987), hsa-mir-149-5p (MIRT045453)

    Block miRNA regulation of human, mouse, rat HEATR2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HEATR2:
    hsa-miR-1305 hsa-miR-3622a-5p
    SwitchGear 3'UTR luciferase reporter plasmidHEATR2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HEATR2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEATR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HEAT2_HUMAN, Q86Y56: Cytoplasm. Note=Observed only in the cytoplasm of ciliated airway epithelial cells. Absent
    from cilia
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    HEATR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HEATR2
    Interactions:

        Search GeneGlobe Interaction Network for HEATR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for HEATR2 (Q86Y562, 3 ENSP000002974404) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBTB16Q055162, 3MINT-64841 I2D: score=5 
    FEZ1Q996892, 3, ENSP000002789194MINT-64842 I2D: score=5 STRING: ENSP00000278919
    SAP18O004223, ENSP000003719734I2D: score=1 STRING: ENSP00000371973
    PGRMC1O002643, ENSP000002179714I2D: score=2 STRING: ENSP00000217971
    PNKPQ96T603, ENSP000003235114I2D: score=2 STRING: ENSP00000323511
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HEATR2 (HEAT2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HEATR2 gene: 
    NM_017802.3  

    Unigene Cluster for HEATR2:

    HEAT repeat containing 2
    Hs.535896  [show with all ESTs]
    Unigene Representative Sequence: AK125479
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297440(uc010krz.1 uc003siz.2 uc003sjb.2) ENST00000437419
    ENST00000438961 ENST00000440747 ENST00000491496(uc003sja.3) ENST00000403952(uc003sjc.2)
    ENST00000486546 ENST00000461576 ENST00000313147
    miRNA
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    Block miRNA regulation of human, mouse, rat HEATR2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HEATR2:
    hsa-miR-1305 hsa-miR-3622a-5p
    SwitchGear 3'UTR luciferase reporter plasmidHEATR2 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HEATR2
      QuantiTect SYBR Green Assays in human, mouse, rat HEATR2
      QuantiFast Probe-based Assays in human, mouse, rat HEATR2

    Additional mRNA sequence: 

    AK000404.1 AK054595.1 AK056233.1 AK096700.1 AK098430.1 AK125479.1 AK127690.1 AK225507.1 
    AL832914.1 BC010850.1 BC047240.1 BC094840.1 NR_075098.1 

    18 DOTS entries:

    DT.320263  DT.100644345  DT.100785152  DT.97796293  DT.441345  DT.100785149  DT.92424447  DT.100785153 
    DT.101960785  DT.97822201  DT.92042007  DT.95171644  DT.97854140  DT.100804218  DT.95171647  DT.40267483 
    DT.95171650  DT.97844926 

    Selected AceView cDNA sequences (see all 115):

    BM756077 BM703013 BQ272448 BM702962 BI762953 CB215545 CD245719 CA424295 
    CA392586 R99542 AI361872 BU194106 BF793636 AK098430 BM721726 BM714707 
    AA053037 BM721750 AA573508 BV179547 N63199 BG180585 BU737220 BU601412 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HEATR2 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^
    SP1:                                                                                      -     -     -           -                 -                           
    SP2:                                -                                                                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                              -                 -                           

    ExUns: 17a · 17b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for HEATR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HEATR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGAAAATT
    HEATR2 Expression
    About this image

    HEATR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HEATR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.535896
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HEATR2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Heatr21 , 5 HEAT repeat containing 21, 5 78.68(n)1
    77.82(a)1
      5 (78.02 cM)5
    4339561  NM_001081265.11  NP_001074734.11 
     1391502235 
    chicken
    (Gallus gallus)
    Aves HEATR21 HEAT repeat containing 2 63(n)
    60.08(a)
      416447  XM_414755.3  XP_414755.2 
    lizard
    (Anolis carolinensis)
    Reptilia HEATR26
    HEAT repeat containing 2
    58(a)
    1 ↔ 1
    GL343385.1(640741-651451)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480124432   -- 75.19(n)    48012443 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003336601 HEAT repeat-containing protein 2-like 59.97(n)
    55.83(a)
      100333660  XM_002667551.3  XP_002667597.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG313201 CG31320 43.65(n)
    31.29(a)
      318680  NM_169581.2  NP_731905.1 


    ENSEMBL Gene Tree for HEATR2 (if available)
    TreeFam Gene Tree for HEATR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HEATR2 gene

    HEATR2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HEATR2
    PGOHUM00000245552


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HEATR2 (see all 1959)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0689694
    Ciliary dyskinesia, primary, 18 (CILD18)4--see VAR_0689692 L P mis40--------
    rs1499809151,2
    C,F--769344(+) TGATGC/GAGACC 3 Q E int1 mis12Minor allele frequency- G:0.00NA EU 5863
    rs43988151,2
    C--769400(+) ACAGGC/TGCAGT 3 G syn1 ese32Minor allele frequency- T:0.00NA 4
    rs1491393471,2
    C,F--769401(+) CAGGCG/ACAGTG 3 /T /A nc-transcript-variantmis11Minor allele frequency- A:0.00NA 4548
    rs1150585791,2
    C--769411(+) GATCCA/TTTTTG 3 H L mis10--------
    rs1421416601,2
    C--769422(+) GCAACG/AGGAAG 3 /R /G mis11Minor allele frequency- A:0.00NA 4548
    rs1998543821,2
    C--769476(+) ATGACG/ATCCCG 3 /I /V nc-transcript-variantmis11Minor allele frequency- A:0.00EU 1319
    rs1460149161,2
    C--769481(+) GTCCCG/TCAGGT 3 P syn11Minor allele frequency- T:0.00NA 4548
    rs788442511,2
    C,F--769651(+) AAACTA/GGAAGA 2 -- int11Minor allele frequency- G:0.02NA 120
    rs800576501,2
    C,F--769719(+) CTTGTG/ATAGTT 2 -- int11Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for HEATR2 (766338 - 829190 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HEATR2 (see all 33):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv992419CNV Deletion20482838
    esv2733664CNV Deletion23290073
    esv2676392CNV Deletion23128226
    esv1277926CNV Deletion17803354
    esv2743076CNV Deletion23290073
    esv2733658CNV Deletion23290073
    esv2733663CNV Deletion23290073
    esv1364544CNV Deletion17803354
    esv2733667CNV Deletion23290073
    dgv1107e201CNV Deletion23290073

    Human Gene Mutation Database (HGMD): HEATR2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HEATR2
    DNA2.0 Custom Variant and Variant Library Synthesis for HEATR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614864   
    OMIM disorders: 614874  
    UniProtKB/Swiss-Prot: HEAT2_HUMAN, Q86Y56
  • Ciliary dyskinesia, primary, 18 (CILD18) [MIM:614874]: A disorder characterized by abnormalities of
    motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to
    defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of
    sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to
    dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is
    referred to as Kartagener syndrome. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 10 diseases for HEATR2:    About MalaCards
    primary ciliary dyskinesia18: heatr2-related primary ciliary dyskinesia    ciliary dyskinesia, primary, 18    primary ciliary dyskinesia    kartagener syndrome
    ciliary dyskinesia, primary, 19    bronchiectasis    situs inversus    multiple myeloma
    myeloma    malaria

    1 disease from the University of Copenhagen DISEASES database for HEATR2:
    Primary ciliary dyskinesia

    HEATR2 for disorders           About GeneDecksing


    Export disorders for HEATR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HEATR2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with HEATR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia. (PubMed id 23040496)1, 2, 3 Horani A.... Ferkol T.W. (Am. J. Hum. Genet. 2012)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    5. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    6. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54919 HGNC: 26013 AceView: FLJ20397.1 Ensembl:ENSG00000164818 euGenes: HUgn54919
    ECgene: HEATR2 H-InvDB: HEATR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HEATR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HEATR2 gene:
    Search GeneIP for patents involving HEATR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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