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HEATR1 Gene

protein-coding   GIFtS: 54
GCID: GC01M236712

HEAT Repeat Containing 1

  Search for HEATR1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HEAT Repeat Containing 11 2     Small Subunit (SSU) Processome Component1
UTP101 2     HEAT Repeat-Containing Protein 12
Protein BAP282 3     UTP10, Small Subunit (SSU) Processome Component, Homolog2
BAP282 3     EC 4.1.1.318
Homolog (Yeast)1     EC 6.3.4.48

External Ids:    HGNC: 255171   Entrez Gene: 551272   Ensembl: ENSG000001192857   UniProtKB: Q9H5833   

Export aliases for HEATR1 gene to outside databases

Previous GC identifers: GC01M233039 GC01M234778 GC01M207169


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HEATR1 Gene:
HEATR1 (HEAT repeat containing 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: HEAT1_HUMAN, Q9H583
Function: Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By
similarity)

Gene Wiki entry for HEATR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HEATR1 gene promoter:
         Nkx3-1   GATA-3   ATF-2   STAT5A   Tal-1beta   Evi-1   E47   Nkx6-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHEATR1 promoter sequence
   Search Chromatin IP Primers for HEATR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HEATR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q43   Ensembl cytogenetic band:  1q43   HGNC cytogenetic band: 1q43

HEATR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HEATR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M236712:  view genomic region     (about GC identifiers)

Start:
236,712,305 bp from pter      End:
236,767,841 bp from pter
Size:
55,537 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HEAT1_HUMAN, Q9H583 (See protein sequence)
Recommended Name: HEAT repeat-containing protein 1  
Size: 2144 amino acids; 242370 Da
Sequence caution: Sequence=BAA91564.1; Type=Erroneous initiation;
Secondary accessions: Q5T3Q8 Q6P197 Q9NW23

Explore the universe of human proteins at neXtProt for HEATR1: NX_Q9H583

Explore proteomics data for HEATR1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1483, Lys1575, Lys1643
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for HEATR1 (Q9H583)
     FLAELME  ALQKVVE 


    See HEATR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060542.4  
    ENSEMBL proteins: 
     ENSP00000355541   ENSP00000355540   ENSP00000355538  

    HEATR1 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HEATR1

     
    Search eBioscience for Proteins for HEATR1 

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    Cloud-Clone Corp. ELISAs for HEATR1
    Cloud-Clone Corp. CLIAs for HEATR1
    Search eBioscience for ELISAs for HEATR1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR022125 U3snoRNP10
     IPR011989 ARM-like
     IPR012954 BP28_C_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9H583

    ProtoNet protein and cluster: Q9H583

    2 Blocks protein domains:
    IPB000357 HEAT repeat
    IPB012954 BP28


    UniProtKB/Swiss-Prot: HEAT1_HUMAN, Q9H583
    Similarity: Belongs to the HEATR1/UTP10 family
    Similarity: Contains 1 HEAT repeat


    Find genes that share domains with HEATR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HEAT1_HUMAN, Q9H583
    Function: Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By
    similarity)

         Enzyme Numbers (IUBMB): EC 6.3.4.42 EC 4.1.1.312

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with HEATR1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for HEATR1:
     Decreased p24 protein expressi  Decreased viability of wild-ty  Nuclear 40S maturation defects  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HEATR1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HEATR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HEATR1

    miRNA
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    miRTarBase miRNAs that target HEATR1:
    hsa-mir-92a-3p (MIRT049239), hsa-mir-16-5p (MIRT031828), hsa-mir-615-3p (MIRT039888), hsa-mir-106a-5p (MIRT048324)

    Block miRNA regulation of human, mouse, rat HEATR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HEATR1 (see all 25):
    hsa-miR-3910 hsa-miR-548j hsa-miR-4254 hsa-miR-548i hsa-miR-649 hsa-miR-124 hsa-miR-506 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidHEATR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HEATR1

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    GenScript: all cDNA clones in your preferred vector: HEATR1 (NM_018072)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEATR1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for HEATR1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEATR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HEAT1_HUMAN, Q9H583: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    plasma membrane3
    cytosol1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0030529ribonucleoprotein complex IEA--

    Find genes that share ontologies with HEATR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HEATR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes


    Find genes that share SuperPaths with HEATR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for HEATR1):
        Ribosome biogenesis in eukaryotes

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HEATR1
    Interactions:

        Search GeneGlobe Interaction Network for HEATR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HEATR1 (Q9H5831, 2, 3 ENSP000003555414) via UniProtKB, MINT, STRING, and/or I2D (see all 252)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--

    Find genes that share ontologies with HEATR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HEATR1 (HEAT1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HEATR1 gene: 
    NM_018072.5  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366582(uc009xgh.2 uc001hyd.2) ENST00000366581 ENST00000490339
    ENST00000483073 ENST00000366579(uc001hye.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat HEATR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HEATR1 (see all 25):
    hsa-miR-3910 hsa-miR-548j hsa-miR-4254 hsa-miR-548i hsa-miR-649 hsa-miR-124 hsa-miR-506 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidHEATR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HEATR1
    Predesigned siRNA for gene silencing in human, mouse, rat HEATR1
    Clone
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    OriGene clones in human, mouse for HEATR1 (see all 6)
    OriGene ORF clones in mouse, rat for HEATR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HEATR1 (NM_018072)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HEATR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEATR1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HEATR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HEATR1
      QuantiTect SYBR Green Assays in human, mouse, rat HEATR1
      QuantiFast Probe-based Assays in human, mouse, rat HEATR1

    Selected AceView cDNA sequences (see all 240):

    BP872835 BQ227149 AA909823 AI114709 CK825220 AW468736 BM789333 BE220019 
    AK001221 AW663571 AA436617 CA413253 CR626198 AK001857 AA477189 AA836949 
    BM792741 AI079533 AI417974 AI886585 AA479792 AA149823 AW613828 BG231504 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HEATR1 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a ·
    SP1:                                                                                                                                                            
    SP2:                          -                                               -                                                                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a ·
    SP1:                                -     -     -     -                                                                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                -                                                                                                                           
    SP5:                                -                                                                                                                           

    ExUns: 39b ^ 40 ^ 41a · 41b ^ 42 ^ 43 ^ 44 ^ 45
    SP1:                    -                           
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for HEATR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HEATR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACTTTTGG
    HEATR1 Expression
    About this image


    HEATR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Testis (Reproductive System)
    HEATR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HEATR1 Protein Expression
        Custom PCR Arrays for HEATR1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEATR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HEATR1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Heatr11 , 5 HEAT repeat containing 11, 5 83.17(n)1
    83.85(a)1
      13 (4.56 cM)5
    2179951  NM_144835.41  NP_659084.31 
     123953985 
    chicken
    (Gallus gallus)
    Aves HEATR11 HEAT repeat containing 1 69.17(n)
    65.97(a)
      425734  XM_004935466.1  XP_004935523.1 
    lizard
    (Anolis carolinensis)
    Reptilia HEATR16
    HEAT repeat containing 1
    52(a)
    1 ↔ 1
    1(218926082-218963453)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.35162 Xenopus laevis transcribed sequence with moderate similarity more 72.77(n)    BX850230.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi69e122 wufi69e12 72.37(n)   334446  BC055128.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)k090221 lethal (2) k09022 45.96(n)
    34.47(a)
      33960  NM_135235.2  NP_609079.2 
    worm
    (Caenorhabditis elegans)
    Secernentea toe-11 toe-1 41.57(n)
    27.59(a)
      173779  NM_062381.4  NP_494782.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UTP10(YJL109C)4 Nucleolar protein, component of the small subunit (SSU) more   --   10(217309-212000) 853335  NP_012426.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G065301 AT3G06530 41.78(n)
    27.37(a)
      819831  NM_001202900.1  NP_001189829.1 


    ENSEMBL Gene Tree for HEATR1 (if available)
    TreeFam Gene Tree for HEATR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HEATR1 (see all 1645)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1152370981,2
    C,F--236716833(+) TAGGCT/CATGCA 1 -- int12Minor allele frequency- C:0.03NA EA 240
    rs2022009351,2
    --236716887(+) TTAGGC/TGAGGA 2 S syn10--------
    rs66647301,2,,4
    C,F,H--236716888(+) TAGGCG/AAGGAG 2 /S /L mis1 ese311Minor allele frequency- A:0.04NS EA NA WA EU 6461
    rs2008541691,2
    C--236716900(+) CTCTCA/GTCTTT 2 T M mis10--------
    rs1491452081,2
    C,F--236716934(+) TTTCCA/GAAGAG 2 R W mis12Minor allele frequency- G:0.00NA EU 5873
    rs1875080751,2
    C--236716947(+) TCATCC/TGCCAT 2 A syn10--------
    rs22756851,2
    C,F,A,H--236716959(+) GCCACT/CGAAAA 2 /S syn127Minor allele frequency- C:0.44EA MN NS NA CSA WA EU 9973
    rs1413391611,2
    F--236716974(+) GCGATG/ACATGG 2 /C syn11Minor allele frequency- A:0.00NA 4550
    rs1390220591,2
    F--236716985(+) TATCAG/CGTGCT 2 /L /V mis11Minor allele frequency- C:0.00NA 4550
    rs2003550031,2
    --236717013(+) AATTTC/TTCTTC 2 E syn10--------

    HapMap Linkage Disequilibrium report for HEATR1 (236712305 - 236767841 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for HEATR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725451CNV Deletion23290073
    esv2002103CNV Deletion18987734
    dgv552n71CNV Loss21882294
    esv995705CNV Gain20482838
    dgv60n27CNV Gain19166990
    nsv516855CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with HEATR1           About GenesLikeMe

    Genetic Association Database (GAD): HEATR1
    Human Genome Epidemiology (HuGE) Navigator: HEATR1 (1 document)

    Export disorders for HEATR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HEATR1 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with HEATR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. (PubMed id 17699751)1, 3 Prieto J.L. and McStay B. (amp 2007)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    5. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55127 HGNC: 25517 AceView: FLJ10359 Ensembl:ENSG00000119285 euGenes: HUgn55127
    ECgene: HEATR1 Kegg: 55127 H-InvDB: HEATR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HEATR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HEATR1 gene:
    Search GeneIP for patents involving HEATR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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