HDX Gene
protein-coding GIFtS: 46
GCID: GC0XM083572
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highly divergent homeobox(Previous name: chromosome X open reading frame 43 )
(Previous symbol: CXorf43)
| |
Aliases
for HDX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Highly Divergent Homeobox1 2 | | D030011N01Rik2 | | CXorf431 2 3 | | GPHPX5 | | FLJ306781 | | PHP5 | | Chromosome X Open Reading Frame 431 | | |
Export aliases for HDX gene to outside databasesPrevious GC identifers: GC0XM083459 GC0XM077147 |
Summaries
for HDX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HDX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HDX gene promoter:
Pbx1a AML1a Egr-1 Pax-2 RelA CUTL1 NF-kappaB MEF-2A aMEF-2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HDX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq21.1 Ensembl cytogenetic band: Xq21.1 HGNC cytogenetic band: Xq21.1HDX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM083572: view genomic region
(about GC identifiers)
Start:
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83,572,882 bp from pter |
End:
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83,757,487 bp from pter |
Size:
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184,606 bases |
Orientation:
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minus strand |
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Proteins
for HDX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HDX_HUMAN, Q7Z353 (See
protein sequence)Recommended Name: Highly divergent homeobox Size: 690 amino acids; 77206 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=CAI42095.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from  and Proteopedia  for HDX:2DA4 (3D)
Secondary accessions: A8K1Y5 B7ZL18 Q5JZB4 Q96NK7Alternative splicing: 2 isoforms: Q7Z353-1 Q7Z353-2 Explore the universe of human proteins at neXtProt for HDX: NX_Q7Z353
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z353
HDX Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001170949.1 NP_001170950.1 NP_653258.2
ENSEMBL proteins: ENSP00000297977 ENSP00000362272 ENSP00000423670 ENSP00000387790
Human Recombinant Protein Products for HDX:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
HDX for ontologies About GeneDecksing
HDX Antibody Products:
Assay Products for HDX: |
Protein
Domains /
Families
for HDX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HDX for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z353ProtoNet protein and cluster: Q7Z353 UniProtKB/Swiss-Prot: HDX_HUMAN, Q7Z353Similarity: Contains 2 homeobox DNA-binding domains |
Function
for HDX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
HDX for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for HDX:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Hdx):
HDX for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDX (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDX (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): HDX (NM_144657) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HDX | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDX |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDX |
|
Pathways & Interactions
for HDX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HDX
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for HDX (Q7Z3533 ENSP000002979774) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for HDX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HDX
Search CenterWatch for drugs/clinical trials and news about HDX
|
Transcripts
for HDX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HDX gene (3 alternative transcripts): NM_001177478.1 NM_001177479.1 NM_144657.4 Unigene Cluster for HDX: Highly divergent homeobox Hs.559546 [show with all ESTs]Unigene Representative Sequence: NM_0011774795 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000297977(uc011mqv.2 uc004eel.2 uc004eek.2) ENST00000373177
ENST00000506585 ENST00000472135 ENST00000449553
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDX (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDX (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): HDX (NM_144657) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HDX | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDX |
Additional cDNA sequence: AK055240.1 AK290050.1 BC101720.1 BC101722.1 BC143522.1 BX538112.1 BX649166.1 6 DOTS entries: DT.40299958 DT.121312066 DT.101963862 DT.40282730 DT.121312067 DT.40127193 23 AceView cDNA sequences: BX649166 BX538112 CN482942 NM_144657 CB160004 AK055240 AL707138 BI497112 BX102212 AI564135 CA844238 CA866462 BG460132 BU686266 AI263178 AA927183 BX489268 BE157560 AA969889 W25547 AA625538 W19337 BE157489
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HDX (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|
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| SP1: | | | | | | | - | | - | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HDX
|
Expression
for HDX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HDX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTTCACCA
About this image
See HDX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HDX
SOURCE GeneReport for Unigene cluster: Hs.559546
SABiosciences Custom PCR Arrays for HDX
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HDX
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HDX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDX | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDX |
Orthologs
for HDX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HDX gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for HDX (if available)
TreeFam Gene Tree for HDX (if available) |
Paralogs
for HDX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HDX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HDX (83572882 - 83757487 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HDX: --
Human Gene Mutation Database (HGMD): HDX
Locus Specific Mutation Databases (LSDB): HDX
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HDX |
|
Disorders
/ Diseases
for HDX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HDX for disorders About GeneDecksing
OMIM gene information: 312000
OMIM disorders: --
2  diseases for HDX: About MalaCardspanhypopituitarism x-linked panhypopituitarism
Export disorders for HDX gene to outside databases
|
Publications
for HDX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HDX gene integrated from 9 sources:
(articles sorted by number of sources associating them with HDX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for HDX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HDX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HDX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HDX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HDX | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HDX gene:
Search GeneIP for patents involving HDX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HDX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HDX | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDX | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HDX | | | OriGene Protein Over-expression Lysate for HDX | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HDX | | OriGene 3'-UTR Clone for HDX | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDX | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDX | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HDX | | OriGene Custom Protein Services for HDX | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HDX | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HDX | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDX | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDX |
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| | | | Search Tocris compounds for HDX |
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 | | | HDX Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDX |
|  |  |  |  | | | | Search ThermoFisher Antibodies for HDX |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDX |
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