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Aliases for HDX Gene

Aliases for HDX Gene

  • Highly Divergent Homeobox 2 3
  • CXorf43 3 4
  • Chromosome X Open Reading Frame 43 2
  • D030011N01Rik 3

External Ids for HDX Gene

Previous HGNC Symbols for HDX Gene

  • CXorf43

Previous GeneCards Identifiers for HDX Gene

  • GC0XM083459
  • GC0XM083572
  • GC0XM077147

Summaries for HDX Gene

GeneCards Summary for HDX Gene

HDX (Highly Divergent Homeobox) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDX Gene

Genomics for HDX Gene

Regulatory Elements for HDX Gene

Genomic Location for HDX Gene

84,317,874 bp from pter
84,502,584 bp from pter
184,711 bases
Minus strand

Genomic View for HDX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HDX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDX Gene

Proteins for HDX Gene

  • Protein details for HDX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Highly divergent homeobox
    Protein Accession:
    Secondary Accessions:
    • A8K1Y5
    • B7ZL18
    • Q5JZB4
    • Q96NK7

    Protein attributes for HDX Gene

    690 amino acids
    Molecular mass:
    77206 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI42095.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HDX Gene

    Alternative splice isoforms for HDX Gene


neXtProt entry for HDX Gene

Proteomics data for HDX Gene at MOPED

Post-translational modifications for HDX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HDX Gene

No data available for DME Specific Peptides for HDX Gene

Domains & Families for HDX Gene

Gene Families for HDX Gene

Protein Domains for HDX Gene


Suggested Antigen Peptide Sequences for HDX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 homeobox DNA-binding domains.
  • Contains 2 homeobox DNA-binding domains.
genes like me logo Genes that share domains with HDX: view

Function for HDX Gene

Gene Ontology (GO) - Molecular Function for HDX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with HDX: view
genes like me logo Genes that share phenotypes with HDX: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HDX

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HDX Gene

Localization for HDX Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDX Gene


Subcellular locations from

Jensen Localization Image for HDX Gene COMPARTMENTS Subcellular localization image for HDX gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for HDX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HDX: view

Pathways & Interactions for HDX Gene

SuperPathways for HDX Gene

No Data Available

Interacting Proteins for HDX Gene

Gene Ontology (GO) - Biological Process for HDX Gene


No data available for Pathways by source and SIGNOR curated interactions for HDX Gene

Drugs & Compounds for HDX Gene

No Compound Related Data Available

Transcripts for HDX Gene

Unigene Clusters for HDX Gene

Highly divergent homeobox:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HDX

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDX Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - - -
SP3: - -
SP5: - - - -

Relevant External Links for HDX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HDX Gene

mRNA expression in normal human tissues for HDX Gene

Protein differential expression in normal tissues from HIPED for HDX Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HDX Gene

SOURCE GeneReport for Unigene cluster for HDX Gene Hs.559546

genes like me logo Genes that share expression patterns with HDX: view

Protein tissue co-expression partners for HDX Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HDX Gene

Orthologs for HDX Gene

This gene was present in the common ancestor of chordates.

Orthologs for HDX Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia HDX 35
  • 92.55 (n)
  • 92.02 (a)
HDX 36
  • 92 (a)
(Mus musculus)
Mammalia Hdx 35
  • 90.97 (n)
  • 90.87 (a)
Hdx 16
Hdx 36
  • 90 (a)
(Pan troglodytes)
Mammalia HDX 35
  • 99.57 (n)
  • 99.71 (a)
HDX 36
  • 100 (a)
(Rattus norvegicus)
Mammalia RGD1563666 35
  • 90.58 (n)
  • 91.16 (a)
(Monodelphis domestica)
Mammalia HDX 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia HDX 36
  • 48 (a)
(Gallus gallus)
Aves HDX 35
  • 79.7 (n)
  • 77.03 (a)
HDX 36
  • 76 (a)
(Anolis carolinensis)
Reptilia HDX 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hdx 35
  • 64.7 (n)
  • 58.2 (a)
(Danio rerio)
Actinopterygii LOC797948 35
  • 52.48 (n)
  • 45.67 (a)
HDX 36
  • 39 (a)
Species with no ortholog for HDX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HDX Gene

Gene Tree for HDX (if available)
Gene Tree for HDX (if available)

Paralogs for HDX Gene

No data available for Paralogs for HDX Gene

Variants for HDX Gene

Sequence variations from dbSNP and Humsavar for HDX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs12837911 -- 84,491,803(+) ttaaa(C/T)gcctc intron-variant
rs12837759 -- 84,337,020(+) CAATT(A/C)TACTT intron-variant
rs12836619 -- 84,452,910(+) tgtag(A/G)caaag intron-variant
rs12835865 -- 84,340,663(+) TAGCA(A/C)AATGA intron-variant
rs12835110 -- 84,466,486(+) aattg(G/T)taGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDX Gene

Variant ID Type Subtype PubMed ID
nsv519860 CNV Gain 19592680
esv2740264 CNV Deletion 23290073

Variation tolerance for HDX Gene

Residual Variation Intolerance Score: 23.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.25; 70.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HDX Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDX Gene

Disorders for HDX Gene

Relevant External Links for HDX

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HDX: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDX Gene

Publications for HDX Gene

  1. 14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity. (PMID: 20462248) Zuo S. … Chen X. (J. Proteome Res. 2010) 67
  2. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 67
  3. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 67
  4. Genome-wide association of sleep and circadian phenotypes. (PMID: 17903308) Gottlieb D.J. … Wilk J.B. (BMC Med. Genet. 2007) 67
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67

Products for HDX Gene

Sources for HDX Gene

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