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Aliases for HDX Gene

Aliases for HDX Gene

  • Highly Divergent Homeobox 2 3
  • CXorf43 3 4
  • Chromosome X Open Reading Frame 43 2
  • D030011N01Rik 3

External Ids for HDX Gene

Previous HGNC Symbols for HDX Gene

  • CXorf43

Previous GeneCards Identifiers for HDX Gene

  • GC0XM083459
  • GC0XM083572
  • GC0XM077147

Summaries for HDX Gene

GeneCards Summary for HDX Gene

HDX (Highly Divergent Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDX Gene

Genomics for HDX Gene

Regulatory Elements for HDX Gene

Genomic Location for HDX Gene

Start:
84,317,874 bp from pter
End:
84,502,479 bp from pter
Size:
184,606 bases
Orientation:
Minus strand

Genomic View for HDX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HDX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDX Gene

Proteins for HDX Gene

  • Protein details for HDX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z353-HDX_HUMAN
    Recommended name:
    Highly divergent homeobox
    Protein Accession:
    Q7Z353
    Secondary Accessions:
    • A8K1Y5
    • B7ZL18
    • Q5JZB4
    • Q96NK7

    Protein attributes for HDX Gene

    Size:
    690 amino acids
    Molecular mass:
    77206 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI42095.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HDX Gene

    Alternative splice isoforms for HDX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDX Gene

Proteomics data for HDX Gene at MOPED

Post-translational modifications for HDX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HDX Gene

No data available for DME Specific Peptides for HDX Gene

Domains for HDX Gene

Gene Families for HDX Gene

HGNC:
  • POU :Homeoboxes / POU class

Protein Domains for HDX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HDX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z353

UniProtKB/Swiss-Prot:

HDX_HUMAN :
  • Q7Z353
Domain:
  • Contains 2 homeobox DNA-binding domains.
genes like me logo Genes that share domains with HDX: view

Function for HDX Gene

Gene Ontology (GO) - Molecular Function for HDX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with HDX: view

Phenotypes for HDX Gene

MGI mutant phenotypes for HDX:
inferred from 1 alleles
GenomeRNAi human phenotypes for HDX:
genes like me logo Genes that share phenotypes with HDX: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HDX

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HDX Gene

Localization for HDX Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDX Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HDX Gene COMPARTMENTS Subcellular localization image for HDX gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for HDX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HDX: view

Pathways for HDX Gene

SuperPathways for HDX Gene

No Data Available

Interacting Proteins for HDX Gene

Gene Ontology (GO) - Biological Process for HDX Gene

None

No data available for Pathways by source for HDX Gene

Transcripts for HDX Gene

Unigene Clusters for HDX Gene

Highly divergent homeobox:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HDX

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HDX
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDX Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - - - -
SP6:

Relevant External Links for HDX Gene

GeneLoc Exon Structure for
HDX
ECgene alternative splicing isoforms for
HDX

Expression for HDX Gene

mRNA expression in normal human tissues for HDX Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HDX Gene

SOURCE GeneReport for Unigene cluster for HDX Gene Hs.559546

genes like me logo Genes that share expressions with HDX: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HDX Gene

Orthologs for HDX Gene

This gene was present in the common ancestor of chordates.

Orthologs for HDX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDX 35
  • 99.57 (n)
  • 99.71 (a)
HDX 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HDX 35
  • 92.55 (n)
  • 92.02 (a)
HDX 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hdx 35
  • 90.97 (n)
  • 90.87 (a)
Hdx 16
Hdx 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HDX 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HDX 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1563666 35
  • 90.58 (n)
  • 91.16 (a)
chicken
(Gallus gallus)
Aves HDX 35
  • 79.7 (n)
  • 77.03 (a)
HDX 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HDX 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdx 35
  • 64.7 (n)
  • 58.2 (a)
zebrafish
(Danio rerio)
Actinopterygii HDX 36
  • 39 (a)
OneToOne
LOC797948 35
  • 52.48 (n)
  • 45.67 (a)
Species with no ortholog for HDX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HDX Gene

ENSEMBL:
Gene Tree for HDX (if available)
TreeFam:
Gene Tree for HDX (if available)

Paralogs for HDX Gene

No data available for Paralogs for HDX Gene

Variants for HDX Gene

Sequence variations from dbSNP and Humsavar for HDX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs372117 -- 84,465,306(+) cccag(C/G)aatcc intron-variant
rs372610 -- 84,465,276(+) CAAGG(A/T)TCTAG intron-variant
rs736729 -- 84,336,006(+) AACAA(A/C)AAAAA intron-variant
rs742726 -- 84,358,228(+) AAATA(A/T)CTAAA intron-variant
rs761347 -- 84,373,338(+) TCTTG(A/G)CACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDX Gene

Variant ID Type Subtype PubMed ID
nsv519860 CNV Gain 19592680
esv2740264 CNV Deletion 23290073

Relevant External Links for HDX Gene

HapMap Linkage Disequilibrium report
HDX
Human Gene Mutation Database (HGMD)
HDX
Locus Specific Mutation Databases (LSDB)
HDX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDX Gene

Disorders for HDX Gene

Relevant External Links for HDX

Genetic Association Database (GAD)
HDX
genes like me logo Genes that share disorders with HDX: view

No data available for UniProtKB/Swiss-Prot for HDX Gene

Publications for HDX Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  4. 14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity. (PMID: 20462248) Zuo S. … Chen X. (J. Proteome Res. 2010) 3
  5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 48

Products for HDX Gene

Sources for HDX Gene

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