Aliases for HDX Gene
Aliases for HDX Gene
External Ids for HDX Gene
- HGNC: 26411
- Entrez Gene: 139324
- Ensembl: ENSG00000165259
- UniProtKB: Q7Z353
Previous HGNC Symbols for HDX Gene
- CXorf43
Previous GeneCards Identifiers for HDX Gene
- GC0XM083459
- GC0XM083572
- GC0XM077147
Summaries for HDX Gene
GeneCards Summary for HDX Gene
HDX (Highly Divergent Homeobox) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDX Gene
Genomics for HDX Gene
Regulatory Elements for HDX Gene
Enhancers for HDX Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH0XG084501 | 0.6 | ENCODE | 0.7 | +0.5 | 487 | 1.8 | L3MBTL2 ZBTB21 TAF1 NRF1 RAD21 ATF2 YY1 POLR2A CREB1 CREM | HDX ENSG00000233484 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HDX on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HDX gene promoter:
Regulatory Element Products
Genomic Location for HDX Gene
- Chromosome:
- X
- Start:
- 84,317,874 bp from pter
- End:
- 84,502,584 bp from pter
- Size:
- 184,711 bases
- Orientation:
- Minus strand
Genomic View for HDX Gene
Genes around HDX on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq21.1 by Ensembl
- Xq21.1 by Entrez Gene
- Xq21.1 by HGNC
HDX Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HDX Gene
Proteins for HDX Gene
-
Protein details for HDX Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z353-HDX_HUMAN
- Recommended name:
- Highly divergent homeobox
- Protein Accession:
- Q7Z353
- A8K1Y5
- B7ZL18
- Q5JZB4
- Q96NK7
Protein attributes for HDX Gene
- Size:
- 690 amino acids
- Molecular mass:
- 77206 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=CAI42095.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for HDX Gene
Post-translational modifications for HDX Gene
Other Protein References for HDX Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HDX
- Invitrogen Antibodies for HDX
- GeneTex HDX antibody for HDX
Protein Products
-
OriGene Purified Proteins for HDX
- Search Origene for MassSpec and Protein Over-expression Lysates for HDX
- Origene Custom Protein Services for HDX
- Search GeneTex for Proteins for HDX
Assay Products
No data available for DME Specific Peptides for HDX Gene
Domains & Families for HDX Gene
Gene Families for HDX Gene
Protein Domains for HDX Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HDX Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HDX Gene
Function for HDX Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for HDX Gene
- MGI mutant phenotypes for HDX:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HDX:
-
- Increased viability
- Decreased viability
- Decreased viability in esophageal squamous lineage
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Decreased POU5F1-GFP protein expression
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Effect on mitosis
- Decreased IL-8 secretion
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HDX gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HDX gene
- Search ViGene Biosciences for HDX
CRISPR Products
-
OriGene CRISPR knockouts for HDX
-
Santa Cruz Biotechnology (SCBT) CRISPR for HDX
- GenScript: Design CRISPR guide RNA sequences for HDX
miRNA for HDX Gene
- miRTarBase miRNAs that target HDX
miRNA Products
- Search ViGene Biosciences for HDX
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HDX
- Browse OriGene Inhibitory RNA Products For HDX
-
ViGene Biosciences ready-to-package AAV shRNAs for HDX gene
Cell Line Products
-
Horizon Cell Lines for HDX
-
ViGene Biosciences adenoviral particle packaged cDNA for HDX gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HDX gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HDX gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HDX Gene
Localization for HDX Gene
Subcellular locations from UniProtKB/Swiss-Prot for HDX Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Transcripts for HDX Gene
mRNA/cDNA for HDX Gene
- (8) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (23) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HDX Gene
- Highly divergent homeobox:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for HDX
-
Santa Cruz Biotechnology (SCBT) CRISPR for HDX
- GenScript: Design CRISPR guide RNA sequences for HDX
miRNA Products
- Search ViGene Biosciences for HDX
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HDX
- Browse OriGene Inhibitory RNA Products For HDX
-
ViGene Biosciences ready-to-package AAV shRNAs for HDX gene
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP6: |
Expression for HDX Gene
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HDX Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HDX Gene:
HDXSOURCE GeneReport for Unigene cluster for HDX Gene:
Hs.559546Evidence on tissue expression from TISSUES for HDX Gene
- Intestine(4.2)
- Heart(4.1)
- Lung(4.1)
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for HDX
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDX Gene
Orthologs for HDX Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HDX 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HDX 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hdx 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | RGD1563666 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HDX 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HDX 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HDX 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HDX 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hdx 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC797948 34 |
|
||
| HDX 35 |
|
OneToOne |
- Species where no ortholog for HDX was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HDX Gene
No data available for Paralogs for HDX Gene
Variants for HDX Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004518 | -- | 84,466,642(+) | GTAAA(A/C)TCACA | intron-variant | |
| rs1000012299 | -- | 84,400,672(+) | TACCA(C/T)TGACA | intron-variant | |
| rs1000046092 | -- | 84,473,446(+) | ATAAA(A/G)AAGAC | intron-variant | |
| rs1000047111 | -- | 84,405,844(+) | GCAAT(A/G)TATAA | intron-variant | |
| rs1000067807 | -- | 84,459,230(+) | GAGAT(C/T)AGGAG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2740264 | CNV | deletion | 23290073 |
| nsv519860 | CNV | gain | 19592680 |
Residual Variation Intolerance Score:
23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.25;
70.13% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HDX Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDX Gene
Disorders for HDX Gene
Relevant External Links for HDX
No disorders were found for HDX Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDX Gene
Publications for HDX Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G. … Cagney G. (Sci. Rep. 2015) 3 64
- An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3 64
- 14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity. (PMID: 20462248) Zuo S. … Chen X. (J. Proteome Res. 2010) 3 64
- The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
Products for HDX Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HDX
- Search Origene for MassSpec and Protein Over-expression Lysates for HDX
- Origene Custom Protein Services for HDX
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HDX
- Browse OriGene Inhibitory RNA Products For HDX
- OriGene qPCR primer pairs for HDX
- OriGene CRISPR knockouts for HDX
- OriGene ORF clones in human for HDX
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HDX
- GenScript: Next-day shipping cDNA ORF clone for HDX in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HDX
- GenScript Custom Assay Services for HDX
- GenScript Custom overexpressing Cell Line Services for HDX
- GenScript: Design CRISPR guide RNA sequences for HDX
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HDX
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HDX
- Novus Biologicals proteins and lysates for HDX
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for HDX gene
- ViGene Biosciences lentiviral particle packaged cDNA for HDX gene
- ViGene Biosciences ready-to-package AAV shRNAs for HDX gene
- Search ViGene Biosciences for HDX
- Horizon Cell Lines for HDX
- Cyagen custom Knockout/knockin (KOKI) mouse models for HDX
- VectorBuilder custom plasmid, inducible vectors for HDX
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HDX
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HDX Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer