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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HDLBP Gene

protein-coding GIFtS: 59
GCID: GC02M242166

high density lipoprotein binding protein

(Previous name: vigilin )
(Previous symbol: VGL)

Explore 10 diseases affiliated with
HDLBP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
High Density Lipoprotein Binding Protein¹ ²		High Density Lipoprotein-Binding Protein² ³
VGL¹ ² ³ ⁵		HDL-Binding Protein² ³
HBP¹ ² ³		PRO2900²
Vigilin¹

External Ids:	HGNC: 4857¹	Entrez Gene: 3069²	Ensembl: ENSG00000115677⁷	OMIM: 142695⁵	UniProtKB: Q00341³

Export aliases for HDLBP gene to outside databases

Previous GC identifers: GC02P239181 GC02P240038 GC02M242188 GC02M242489 GC02M242488 GC02M241888 GC02M233922

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HDLBP:

The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol

levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. Three transcript

variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: VIGLN_HUMAN, Q00341

Function: Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of

cholesterol

Gene Wiki entry for HDLBP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005416.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HDLBP gene promoter:
Max1 Nkx3-1 Nkx3-1 v4 Nkx3-1 v1 Nkx3-1 v2 Max Nkx3-1 v3 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HDLBP promoter sequence

Search SABiosciences Chromatin IP Primers for HDLBP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDLBP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.3

HDLBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDLBP gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M242166: view genomic region (about GC identifiers)

Start:	242,166,679 bp from pter	End:	242,256,476 bp from pter
Size:	89,798 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VIGLN_HUMAN, Q00341 (See protein sequence)

Recommended Name: Vigilin

Size: 1268 amino acids; 141456 Da

Subcellular location: Cytoplasm. Nucleus

6/8 PDB 3D structures from and Proteopedia for HDLBP (see all 8):

1VIG (3D)

1VIH (3D)

2CTE (3D)

2CTF (3D)

2CTJ (3D)

2CTK (3D)

Secondary accessions: B4DTQ2 E7EM71 Q53QU2 Q9UCY3

Alternative splicing: 2 isoforms: Q00341-1 Q00341-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HDLBP: NX_Q00341

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q00341

HDLBP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001230829.1 NP_005327.1 NP_976221.1

ENSEMBL proteins:

ENSP00000375836 ENSP00000375837 ENSP00000312042 ENSP00000362389 ENSP00000411211

ENSP00000405180 ENSP00000388876 ENSP00000393766 ENSP00000403807 ENSP00000405109

ENSP00000413891 ENSP00000387782 ENSP00000416559 ENSP00000403913 ENSP00000396964

ENSP00000394205 ENSP00000390290 ENSP00000413805 ENSP00000390942 ENSP00000396202

ENSP00000403693 ENSP00000409868 ENSP00000408582 ENSP00000397799 ENSP00000396959

ENSP00000391773 ENSP00000399139

Human Recombinant Protein Products for HDLBP:

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	GenScript Custom Purified and Recombinant Proteins Services for HDLBP
	Novus Biologicals HDLBP Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HDLBP

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	TAS	1318310
GO:0034364	high-density lipoprotein particle	IEA	--

HDLBP for ontologies About GeneDecksing

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Assay Products for HDLBP:

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	Uscn ELISAs and CLIAs for HDLBP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HDLBP for domains About GeneDecksing

2 InterPro domains/families:

IPR004087 KH_dom

IPR004088 KH_dom_type_1

Graphical View of Domain Structure for InterPro Entry Q00341

ProtoNet protein and cluster: Q00341

2 Blocks protein families:

IPB004087 KH domain

IPB004088 KH

UniProtKB/Swiss-Prot: VIGLN_HUMAN, Q00341

Similarity: Contains 14 KH domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: VIGLN_HUMAN, Q00341

Function: Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of

cholesterol

Genatlas biochemistry entry for HDLBP:

vigilin,high density lipoprotein binding protein

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0008289	lipid binding	TAS	1318310

HDLBP for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for HDLBP:

Synthetic lethal with c-Myc af

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HDLBP

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HDLBP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HDLBP
		8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate HDLBP (see all 64):
		hsa-miR-759 hsa-miR-10b* hsa-miR-642b hsa-miR-92b hsa-miR-761 hsa-miR-4324 hsa-miR-3688-3p hsa-miR-425

		SwitchGear 3'UTR luciferase reporter plasmid: HDLBP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDLBP (see all 6) OriGene siRNA: HDLBP
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDLBP (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDLBP (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HDLBP (NM_203346)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDLBP

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		Sirion Biotech Customized stable knockdown cell line services for HDLBP Sirion Biotech Customized inducible knockdown cell line services for HDLBP Sirion Biotech Customized stable overexpressing cell line services for HDLBP Sirion Biotech Customized inducible overexpressing cell line services for HDLBP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDLBP

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HDLBP

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/932 Interacting proteins for HDLBP (Q00341^{2, 3} ENSP00000312042⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 932)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006869	lipid transport	IEA	--
GO:0008203	cholesterol metabolic process	IEA	--

HDLBP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HDLBP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HDLBP
4 Novoseek chemical compound relationships for HDLBP gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
trna	58.7	10	12792806 (2), 10657246 (2), 9445390 (2), 14618268 (1)
cholesterol	30.5	14	12941645 (2), 1318310 (2), 9409201 (2), 10638200 (1) (see all 6)
estrogen	5.77	4	9632784 (2), 11050168 (1)
lipid	0	2	12941645 (2)

Search CenterWatch for drugs/clinical trials and news about HDLBP / VIGLN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HDLBP gene (3 alternative transcripts):

NM_001243900.1 NM_005336.4 NM_203346.3

Unigene Cluster for HDLBP:

High density lipoprotein binding protein

Hs.471851 [show with all ESTs]

Unigene Representative Sequence: NM_005336

18/47 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 47):

ENST00000391975(uc021vzg.1 uc002waz.3 uc002wba.3) ENST00000391976(uc010fzn.1)

ENST00000310931 ENST00000487169 ENST00000373292 ENST00000484412 ENST00000442730

ENST00000494862 ENST00000488013 ENST00000470482 ENST00000479894 ENST00000483086

ENST00000479169 ENST00000427487 ENST00000459788 ENST00000471294 ENST00000452931

ENST00000460826

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HDLBP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HDLBP
		8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate HDLBP (see all 64):
		hsa-miR-759 hsa-miR-10b* hsa-miR-642b hsa-miR-92b hsa-miR-761 hsa-miR-4324 hsa-miR-3688-3p hsa-miR-425

		SwitchGear 3'UTR luciferase reporter plasmid: HDLBP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDLBP (see all 6) OriGene siRNA: HDLBP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDLBP
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		GenScript: all cDNA clones in your preferred vector (see all 2): HDLBP (NM_203346)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDLBP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDLBP

Additional cDNA sequence:

AF116718.1 AK026138.1 AK127833.1 AK296684.1 AK300312.1 AK309075.1 AK312335.1 BC001179.1

BC007961.2 BC009422.1 BC014305.2 BC021817.1 BC038965.1 BC058826.1 BC113120.1 BX647759.1

M64098.1

24/120 DOTS entries (see all 120):

DT.100060166 DT.100891495 DT.405195 DT.91777154 DT.100891477 DT.97861017 DT.95165709 DT.100891497

DT.95293553 DT.100891486 DT.120964777 DT.100891484 DT.120964528 DT.91777150 DT.91773953 DT.420593

DT.95165778 DT.100891501 DT.120964358 DT.120964485 DT.454461 DT.120964637 DT.100055634 DT.100891492

24/56 AceView cDNA sequences (see all 56):

BG254246 BF437213 BP335239 BX327995 BM803941 BM772516 BM091124 BM471172

BC001179 BM771003 BF062601 BF879833 F02903 CK430628 BC009422 NM_005336

BQ940873 AF116718 BM758212 BU147158 BF872528 CA429273 AI276755 NM_203346

GeneLoc Exon Structure

5/26 Alternative Splicing Database (ASD) splice patterns (SP) for HDLBP (see all 26) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	^	10a	·	10b	·	10c	·	10d	·	10e	^	11a	·	11b	·
SP1:			-		-		-		-		-		-		-		-		-		-
SP2:
SP3:
SP4:			-		-		-		-		-		-						-		-
SP5:					-		-		-		-		-		-		-		-		-

ExUns:	11c	·	11d	·	11e	^	12a	·	12b	^	13a	·	13b	^	14	^	15a	·	15b	^	16a	·	16b	^	17a	·	17b	^	18a	·	18b	·	18c	^	19	^	20	^	21a	·	21b	^	22a	·	22b	·	22c	^	23	^	24a	·
SP1:																													-										-								-		-
SP2:											-		-		-														-										-								-		-
SP3:																																							-								-		-
SP4:
SP5:

ExUns:	24b	^	25a	·	25b	·	25c	·	25d	^	26a	·	26b	^	27	^	28a	·	28b	^	29	^	30	^	31	^	32a	·	32b	^	33a	·	33b	^	34	^	35a	·	35b	·	35c	^	36a	·	36b	^	37
SP1:			-																-				-																		-
SP2:			-																-				-										-		-		-				-
SP3:			-																-				-
SP4:
SP5:

ECgene alternative splicing isoforms for HDLBP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HDLBP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTCAGGAA

About this image

HDLBP expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Cap Mesenchyme

Cap Mesenchyme Cells

Kidney

Kidney

S-shaped Body

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HDLBP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HDLBP

SOURCE GeneReport for Unigene cluster: Hs.471851

SABiosciences Expression via Pathway-Focused PCR Array including HDLBP:

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HDLBP Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDLBP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDLBP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for HDLBP gene from 8/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hdlbp^{1 , 5}	high density lipoprotein (HDL) binding protein^{1, 5}	89.67(n)¹ 97.95(a)¹		1 (47.24 cM)⁵ 110611¹ NM_133808.4¹ NP_598569.1¹ 93405940⁵
chicken (Gallus gallus)	Aves	HDLBP¹	high density lipoprotein binding protein	79.77(n) 87.53(a)		395984 NM_205096.1 NP_990427.1
lizard (Anolis carolinensis)	Reptilia	HDLBP⁶	--	89(a)	1 ↔ 1	3(30209683-30237770)
African clawed frog (Xenopus laevis)	Amphibia	hdlbp-prov²	high density lipoprotein binding protein (vigilin)	77.15(n)		BC044314.1
zebrafish (Danio rerio)	Actinopterygii	hdlbp²	high density lipoprotein-binding protein (vigilin)	76.84(n)		323312 BC051153.1
fruit fly (Drosophila melanogaster)	Insecta	Dp1^{1 , 3}	single-stranded DNA binding³ Dodeca-satellite-binding protein 1¹	39(a)³ 54.34(n)¹ 48.75(a)¹		55C8³ 37116¹ NM_079057.2¹ NP_523781.2¹
worm (Caenorhabditis elegans)	Secernentea	C08H9.2³ CELE_C08H9.2¹	high-density lipoprotein-binding protein³ Protein C08H9.2¹	38(a)³ 49.43(n)¹ 40.41(a)¹		II(9886952-9890851)³ 174543¹ NM_063735.5¹ NP_496136.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SCP160(YJL080C)⁴ SCP160¹	Essential RNA-binding G protein effector of mating more⁴ Scp160p¹	39.74(n)¹ 24.95(a)¹		10(289226-285558)⁴ 853365^{1, 4} NP_012455.1^{1, 4}

ENSEMBL Gene Tree for HDLBP (if available)
TreeFam Gene Tree for HDLBP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HDLBP gene

1 SIMAP similar gene for HDLBP using alignment to 27 protein entries: VIGLN_HUMAN (see all proteins):

DKFZp686L08115

HDLBP for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for HDLBP
PGOHUM00000244869

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs62186360^1,2	C	--	242166212(+)	`AGGAAC/TACCTA`	3	--	ds500¹		6		NA WA EA	364
rs114549516^1,2	F	--	242166283(+)	`CTCAAC/TGCCCC`	3	--	ds500¹		1		WA	118
rs1677^1,2	C,F,H	--	242166550(-)	`CCACAT/CTGAGG`	3	--	ds500¹		28		EA MN NS NA WA CSA	4388
rs6726226^1,2	C,F	--	242166568(+)	`GGGGCT/CGTTGA`	3	--	ds500¹		3		WA CSA	6
rs144586613^1,2	C	--	242166574(+)	`GTTGA-/ACACAGT`	3	--	ds500¹		0	--	--	--	--
rs181863202^1,2		--	242166577(+)	`GAACAC/GAGTGT`	3	--	ds500¹		0	--	--	--	--
rs140895923^1,2		--	242166613(+)	`AAAGAC/TGAACT`	3	--	ds500¹		0	--	--	--	--
rs186237513^1,2		--	242166669(+)	`ACACAA/GGCGGC`	3	--	ds500¹		0	--	--	--	--
rs189144149^1,2		--	242166705(+)	`GCTACA/GTCTGG`	3	--	ut3¹		0	--	--	--	--
rs181622884^1,2		--	242166743(+)	`AATTCC/TAGTGT`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HDLBP (242166679 - 242256476 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HDLBP: --
Human Gene Mutation Database (HGMD): HDLBP

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HDLBP for disorders           About GeneDecksing

OMIM gene information: 142695    OMIM disorders: --

10 diseases for HDLBP:    About MalaCards

cholesterol hdl deficiency graves' disease hepatocellular carcinoma

breast cancer atherosclerosis retinitis carcinoma

hepatitis familial hdl deficiency

Human Genome Epidemiology (HuGE) Navigator: HDLBP (5 documents)

Export disorders for HDLBP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HDLBP gene, integrated from 9 sources (see all 86):
(articles sorted by number of sources associating them with HDLBP)

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Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells. (PubMed id 1318310)^{1, 2, 3, 9} McKnight G.L.... Oram J.F. (1992)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Vigilin contains a functional nuclear localisation sequence and is present in both the cytoplasm and the nucleus. (PubMed id 8605996)^{1, 2} Kugler S....Kruse C. (1996)
Localization of the gene for high-density lipoprotein binding protein (HDLBP) to human chromosome 2q37. (PubMed id 8390966)^{1, 3} Xia Y.R....Lusis A.J. (1993)
High-density lipoprotein-binding protein (HBP)/vigilin is expressed in human atherosclerotic lesions and colocalizes with apolipoprotein E. (PubMed id 9409201)^{1, 9} Chiu D.S....O'Brien K.D. (1997)
Vigilin is co-localized with 80S ribosomes and binds to the ribosomal complex through its C-terminal domain. (PubMed id 15109574)^{1, 9} Vollbrandt T....Kruse C. (2004)
RNAi-mediated depletion of the 15 KH domain protein, vigilin, induces death of dividing and non-dividing human cells but does not initially inhibit protein synthesis. (PubMed id 14500828)^{1, 9} Goolsby K.M. and Shapiro D.J. (2003)
[VIGILIN involves in regulation of imprinting gene IG F2 and H19 in human hepatocellular carcinoma cell] (PubMed id 19950580)^{1, 9} Ge Y.J....Qin Y. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3069	HGNC: 4857	AceView: HDLBP	Ensembl:ENSG00000115677	euGenes: HUgn3069
ECgene: HDLBP	H-InvDB: HDLBP

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HDLBP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HDLBP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HDLBP gene:
Search GeneIP for patents involving HDLBP

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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high density lipoprotein binding protein

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high density lipoprotein binding protein

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