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Aliases for HDHD3 Gene

Aliases for HDHD3 Gene

  • Haloacid Dehalogenase-Like Hydrolase Domain Containing 3 2 3
  • C9orf158 3 4
  • Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 3 3
  • Chromosome 9 Open Reading Frame 158 2
  • 2810435D12Rik 3

External Ids for HDHD3 Gene

Previous HGNC Symbols for HDHD3 Gene

  • C9orf158

Previous GeneCards Identifiers for HDHD3 Gene

  • GC09M113215
  • GC09M115175
  • GC09M116135
  • GC09M085742

Summaries for HDHD3 Gene

GeneCards Summary for HDHD3 Gene

HDHD3 (Haloacid Dehalogenase-Like Hydrolase Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDHD3 Gene

Genomics for HDHD3 Gene

Regulatory Elements for HDHD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HDHD3 Gene

113,373,418 bp from pter
113,377,009 bp from pter
3,592 bases
Minus strand

Genomic View for HDHD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HDHD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDHD3 Gene

Proteins for HDHD3 Gene

  • Protein details for HDHD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Haloacid dehalogenase-like hydrolase domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B2RD47

    Protein attributes for HDHD3 Gene

    251 amino acids
    Molecular mass:
    28000 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HDHD3 Gene

neXtProt entry for HDHD3 Gene

Proteomics data for HDHD3 Gene at MOPED

Post-translational modifications for HDHD3 Gene

  • Ubiquitination at Lys15
  • Modification sites at PhosphoSitePlus

Other Protein References for HDHD3 Gene

No data available for DME Specific Peptides for HDHD3 Gene

Domains for HDHD3 Gene

Suggested Antigen Peptide Sequences for HDHD3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9BSH5
  • Belongs to the HAD-like hydrolase superfamily.
genes like me logo Genes that share domains with HDHD3: view

No data available for Gene Families for HDHD3 Gene

Function for HDHD3 Gene

Gene Ontology (GO) - Molecular Function for HDHD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with HDHD3: view

Animal Model Products

CRISPR Products

miRNA for HDHD3 Gene

miRTarBase miRNAs that target HDHD3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HDHD3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HDHD3 Gene

Localization for HDHD3 Gene

Subcellular locations from

Jensen Localization Image for HDHD3 Gene COMPARTMENTS Subcellular localization image for HDHD3 gene
Compartment Confidence
mitochondrion 2
cytosol 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HDHD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with HDHD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HDHD3 Gene

Pathways for HDHD3 Gene

SuperPathways for HDHD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HDHD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with HDHD3: view

No data available for Pathways by source for HDHD3 Gene

Transcripts for HDHD3 Gene

Unigene Clusters for HDHD3 Gene

Haloacid dehalogenase-like hydrolase domain containing 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HDHD3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDHD3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b
SP1: -
SP2: - -

Relevant External Links for HDHD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HDHD3 Gene

mRNA expression in normal human tissues for HDHD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HDHD3 Gene

This gene is overexpressed in Adrenal Gland (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HDHD3 Gene

SOURCE GeneReport for Unigene cluster for HDHD3 Gene Hs.7739

genes like me logo Genes that share expressions with HDHD3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HDHD3 Gene

Orthologs for HDHD3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HDHD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HDHD3 35
  • 98.8 (n)
  • 99.6 (a)
HDHD3 36
  • 100 (a)
(Bos Taurus)
Mammalia HDHD3 35
  • 85.39 (n)
  • 79.28 (a)
HDHD3 36
  • 79 (a)
(Canis familiaris)
Mammalia HDHD3 35
  • 84.68 (n)
  • 79.44 (a)
HDHD3 36
  • 79 (a)
(Mus musculus)
Mammalia Hdhd3 35
  • 80.72 (n)
  • 77.11 (a)
Hdhd3 16
Hdhd3 36
  • 76 (a)
(Monodelphis domestica)
Mammalia HDHD3 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia HDHD3 36
  • 57 (a)
(Rattus norvegicus)
Mammalia Hdhd3 35
  • 79.38 (n)
  • 76.31 (a)
(Gallus gallus)
Aves HDHD3 36
  • 55 (a)
LOC101747936 35
  • 64.96 (n)
  • 56.84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hdhd3 35
  • 60.74 (n)
  • 54.81 (a)
(Danio rerio)
Actinopterygii hdhd3 35
  • 52.16 (n)
  • 42.24 (a)
hdhd3 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15912 35
  • 47.39 (n)
  • 36.96 (a)
CG15912 36
  • 33 (a)
Reg-2 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea K01G5.10 35
  • 42.41 (n)
  • 31.68 (a)
K01G5.10 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 19 (a)
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G44730 35
  • 39.97 (n)
  • 30.1 (a)
(Oryza sativa)
Liliopsida Os06g0665100 35
  • 43.69 (n)
  • 31.07 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for HDHD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDHD3 Gene

Gene Tree for HDHD3 (if available)
Gene Tree for HDHD3 (if available)

Paralogs for HDHD3 Gene

No data available for Paralogs for HDHD3 Gene

Variants for HDHD3 Gene

Sequence variations from dbSNP and Humsavar for HDHD3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1040989 -- 113,374,713(+) GGCAT(A/T)TACAG intron-variant
rs1040990 -- 113,375,068(+) GGGGC(A/G)GGGTG intron-variant
rs1043836 - 113,373,918(+) GGCCC(C/T)CCAGG missense, reference
rs1746137 -- 113,378,387(+) AACCC(C/T)GTCTC upstream-variant-2KB
rs1746138 -- 113,378,942(+) cttgc(C/T)gcata upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HDHD3 Gene

Variant ID Type Subtype PubMed ID
nsv893744 CNV Gain 21882294
nsv519849 CNV Gain 19592680

Relevant External Links for HDHD3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDHD3 Gene

Disorders for HDHD3 Gene

No disorders were found for HDHD3 Gene.

No data available for UniProtKB/Swiss-Prot for HDHD3 Gene

Publications for HDHD3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K. … Vidal M. (Nat. Methods 2009) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for HDHD3 Gene

  • Addgene plasmids for HDHD3

Sources for HDHD3 Gene

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