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Aliases for HDHD3 Gene

Aliases for HDHD3 Gene

  • Haloacid Dehalogenase Like Hydrolase Domain Containing 3 2 3 5
  • Haloacid Dehalogenase-Like Hydrolase Domain Containing 3 2 3
  • C9orf158 3 4
  • Chromosome 9 Open Reading Frame 158 2
  • 2810435D12Rik 3

External Ids for HDHD3 Gene

Previous HGNC Symbols for HDHD3 Gene

  • C9orf158

Previous GeneCards Identifiers for HDHD3 Gene

  • GC09M113215
  • GC09M115175
  • GC09M116135
  • GC09M085742

Summaries for HDHD3 Gene

GeneCards Summary for HDHD3 Gene

HDHD3 (Haloacid Dehalogenase Like Hydrolase Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDHD3 Gene

Genomics for HDHD3 Gene

Regulatory Elements for HDHD3 Gene

Enhancers for HDHD3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HDHD3 on UCSC Golden Path with GeneCards custom track

Promoters for HDHD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HDHD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HDHD3 Gene

113,373,416 bp from pter
113,377,009 bp from pter
3,594 bases
Minus strand

Genomic View for HDHD3 Gene

Genes around HDHD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDHD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDHD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDHD3 Gene

Proteins for HDHD3 Gene

  • Protein details for HDHD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Haloacid dehalogenase-like hydrolase domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B2RD47

    Protein attributes for HDHD3 Gene

    251 amino acids
    Molecular mass:
    28000 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HDHD3 Gene

neXtProt entry for HDHD3 Gene

Proteomics data for HDHD3 Gene at MOPED

Post-translational modifications for HDHD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HDHD3 Gene

No data available for DME Specific Peptides for HDHD3 Gene

Domains & Families for HDHD3 Gene

Suggested Antigen Peptide Sequences for HDHD3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HAD-like hydrolase superfamily.
  • Belongs to the HAD-like hydrolase superfamily.
genes like me logo Genes that share domains with HDHD3: view

No data available for Gene Families for HDHD3 Gene

Function for HDHD3 Gene

Gene Ontology (GO) - Molecular Function for HDHD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with HDHD3: view
genes like me logo Genes that share phenotypes with HDHD3: view

Animal Model Products

miRNA for HDHD3 Gene

miRTarBase miRNAs that target HDHD3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HDHD3 Gene

Localization for HDHD3 Gene

Subcellular locations from

Jensen Localization Image for HDHD3 Gene COMPARTMENTS Subcellular localization image for HDHD3 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 1
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HDHD3 Gene

Pathways & Interactions for HDHD3 Gene

SuperPathways for HDHD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HDHD3 Gene


No data available for Pathways by source and SIGNOR curated interactions for HDHD3 Gene

Drugs & Compounds for HDHD3 Gene

No Compound Related Data Available

Transcripts for HDHD3 Gene

Unigene Clusters for HDHD3 Gene

Haloacid dehalogenase-like hydrolase domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HDHD3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b
SP1: -
SP2: - -

Relevant External Links for HDHD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HDHD3 Gene

mRNA expression in normal human tissues for HDHD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HDHD3 Gene

This gene is overexpressed in Adrenal Gland (x6.8).

Protein differential expression in normal tissues from HIPED for HDHD3 Gene

This gene is overexpressed in Adrenal (10.5), Salivary gland (9.0), and Skin (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HDHD3 Gene

SOURCE GeneReport for Unigene cluster for HDHD3 Gene Hs.7739

genes like me logo Genes that share expression patterns with HDHD3: view

Protein tissue co-expression partners for HDHD3 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HDHD3 Gene

Orthologs for HDHD3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HDHD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HDHD3 35
  • 85.39 (n)
  • 79.28 (a)
HDHD3 36
  • 79 (a)
(Canis familiaris)
Mammalia HDHD3 35
  • 84.68 (n)
  • 79.44 (a)
HDHD3 36
  • 79 (a)
(Mus musculus)
Mammalia Hdhd3 35
  • 80.72 (n)
  • 77.11 (a)
Hdhd3 16
Hdhd3 36
  • 76 (a)
(Pan troglodytes)
Mammalia HDHD3 35
  • 98.8 (n)
  • 99.6 (a)
HDHD3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hdhd3 35
  • 79.38 (n)
  • 76.31 (a)
(Monodelphis domestica)
Mammalia HDHD3 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia HDHD3 36
  • 57 (a)
(Gallus gallus)
Aves LOC101747936 35
  • 64.96 (n)
  • 56.84 (a)
HDHD3 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hdhd3 35
  • 60.74 (n)
  • 54.81 (a)
(Danio rerio)
Actinopterygii hdhd3 35
  • 52.16 (n)
  • 42.24 (a)
hdhd3 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15912 35
  • 47.39 (n)
  • 36.96 (a)
CG15912 36
  • 33 (a)
Reg-2 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea K01G5.10 35
  • 42.41 (n)
  • 31.68 (a)
K01G5.10 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 19 (a)
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G44730 35
  • 39.97 (n)
  • 30.1 (a)
(Oryza sativa)
Liliopsida Os06g0665100 35
  • 43.69 (n)
  • 31.07 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for HDHD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDHD3 Gene

Gene Tree for HDHD3 (if available)
Gene Tree for HDHD3 (if available)

Paralogs for HDHD3 Gene

No data available for Paralogs for HDHD3 Gene

Variants for HDHD3 Gene

Sequence variations from dbSNP and Humsavar for HDHD3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1043836 - 113,373,918(+) GGCCC(C/T)CCAGG reference, missense
rs1040989 -- 113,374,713(+) GGCAT(A/T)TACAG intron-variant
rs1040990 -- 113,375,068(+) GGGGC(A/G)GGGTG intron-variant
rs7859270 -- 113,372,981(+) AGGTA(A/C)CTCAG downstream-variant-500B
rs1746137 -- 113,378,387(+) AACCC(C/T)GTCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HDHD3 Gene

Variant ID Type Subtype PubMed ID
nsv893744 CNV Gain 21882294
nsv519849 CNV Gain 19592680

Variation tolerance for HDHD3 Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HDHD3 Gene

Disorders for HDHD3 Gene

Relevant External Links for HDHD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HDHD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDHD3 Gene

Publications for HDHD3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K. … Vidal M. (Nat. Methods 2009) 3

Products for HDHD3 Gene

Sources for HDHD3 Gene