HDHD3 Gene
protein-coding GIFtS: 46
GCID: GC09M116135
|
|
haloacid dehalogenase-like hydrolase domain containing 3(Previous name: chromosome 9 open reading frame 158 )
(Previous symbol: C9orf158)
| |
Aliases
for HDHD3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Haloacid Dehalogenase-Like Hydrolase Domain Containing 31 2 | | C9orf1581 2 3 | | MGC129041 | | Chromosome 9 Open Reading Frame 1581 | | 2810435D12Rik2 | | Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 32 |
Export aliases for HDHD3 gene to outside databasesPrevious GC identifers: GC09M113215 GC09M115175 GC09M085742 |
Summaries
for HDHD3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HDHD3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HDHD3 gene promoter:
GR SRF SRF (504 AA) HEN1 PPAR-gamma1 deltaCREB GR-alpha PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HDHD3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDHD3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q32 Ensembl cytogenetic band: 9q32 HGNC cytogenetic band: 9q33.1HDHD3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M116135: view genomic region
(about GC identifiers)
Start:
|
116,135,698 bp from pter |
End:
|
116,139,279 bp from pter |
Size:
|
3,582 bases |
Orientation:
|
minus strand |
|
Proteins
for HDHD3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HDHD3_HUMAN, Q9BSH5 (See
protein sequence)Recommended Name: Haloacid dehalogenase-like hydrolase domain-containing protein 3 Size: 251 amino acids; 28000 Da
1 PDB 3D structure from  and Proteopedia  for HDHD3:3K1Z (3D)
Secondary accessions: B2RD47Explore the universe of human proteins at neXtProt for HDHD3: NX_Q9BSH5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BSH5
HDHD3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_112496.1
ENSEMBL proteins: ENSP00000238379 ENSP00000363295
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
HDHD3 for ontologies About GeneDecksing
HDHD3 Antibody Products:
Assay Products for HDHD3: |
Protein
Domains /
Families
for HDHD3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HDHD3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BSH5ProtoNet protein and cluster: Q9BSH5 1 Blocks protein family: IPB005833 Haloacid dehalogenase/epoxide hydrolase family signature
UniProtKB/Swiss-Prot: HDHD3_HUMAN, Q9BSH5Similarity: Belongs to the HAD-like hydrolase superfamily |
Function
for HDHD3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDHD3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDHD3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HDHD3 (NM_031219) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HDHD3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDHD3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDHD3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
HDHD3 for ontologies About GeneDecksing
|
Pathways & Interactions
for HDHD3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HDHD3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for HDHD3 (Q9BSH51, 2, 3 ENSP000002383794) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for HDHD3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HDHD3
Search CenterWatch for drugs/clinical trials and news about HDHD3
|
Transcripts
for HDHD3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HDHD3 gene: NM_031219.2 Unigene Cluster for HDHD3: Haloacid dehalogenase-like hydrolase domain containing 3 Hs.7739 [show with all ESTs]Unigene Representative Sequence: AK0970673 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000238379(uc004bhi.1) ENST00000374180(uc004bhk.3) ENST00000485934
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDHD3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDHD3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HDHD3 (NM_031219) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HDHD3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDHD3 |
Additional cDNA sequence: AJ420424.1 AK097067.1 AK315401.1 BC005048.2 BC031878.1 9 DOTS entries: DT.416838 DT.100818346 DT.100818342 DT.92429808 DT.100736816 DT.100818349 DT.100818351 DT.95226408 DT.97817840 24/241 AceView cDNA sequences (see all 241): BX509211 BQ675804 AI028089 AI022037 AI241059 CR609038 BC031878 BX509199 AI983942 NM_031219 AL558589 BX342569 BM550395 CB069935 AA341598 BG315225 BI907316 CD675664 BM555357 BM793186 BI755573 AI251738 AI625809 BC005048
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for HDHD3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b |
|---|
|
| SP1: | | | | | - | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HDHD3
|
Expression
for HDHD3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HDHD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAAAACCT
About this image
See HDHD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HDHD3
SOURCE GeneReport for Unigene cluster: Hs.7739
SABiosciences Custom PCR Arrays for HDHD3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HDHD3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HDHD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDHD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDHD3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDHD3 |
Orthologs
for HDHD3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HDHD3 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for HDHD3 (if available)
TreeFam Gene Tree for HDHD3 (if available) |
Paralogs
for HDHD3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HDHD3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HDHD3 (116135698 - 116139279 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HDHD3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HDHD3 |
|
Disorders
/ Diseases
for HDHD3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for HDHD3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HDHD3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HDHD3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
|
External Searches for HDHD3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HDHD3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HDHD3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HDHD3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HDHD3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HDHD3 gene:
Search GeneIP for patents involving HDHD3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HDHD3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HDHD3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDHD3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HDHD3 | | | OriGene Protein Over-expression Lysate for HDHD3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HDHD3 | | OriGene 3'-UTR Clone for HDHD3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDHD3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDHD3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HDHD3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HDHD3 | | OriGene Custom Protein Services for HDHD3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HDHD3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HDHD3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDHD3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDHD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDHD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDHD3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for HDHD3 |
| |  |  |  |  | | | | | | Recombinant Protein for HDHD3 |
|
 |
 |
 |
 | | | HDHD3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDHD3 |
|  |  |  | | | | ThermoFisher Antibody for HDHD3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDHD3 |
|
|
|
|
