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Aliases for HDHD2 Gene

Aliases for HDHD2 Gene

  • Haloacid Dehalogenase Like Hydrolase Domain Containing 2 2 3 5
  • Haloacid Dehalogenase-Like Hydrolase Domain Containing 2 2
  • Epididymis Secretory Protein Li 301 3
  • 3110052N05Rik 3
  • HEL-S-301 3

External Ids for HDHD2 Gene

Previous GeneCards Identifiers for HDHD2 Gene

  • GC18M042887
  • GC18M044633
  • GC18M041481

Summaries for HDHD2 Gene

GeneCards Summary for HDHD2 Gene

HDHD2 (Haloacid Dehalogenase Like Hydrolase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include enzyme binding. An important paralog of this gene is LHPP.

Gene Wiki entry for HDHD2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDHD2 Gene

Genomics for HDHD2 Gene

Regulatory Elements for HDHD2 Gene

Enhancers for HDHD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HDHD2 on UCSC Golden Path with GeneCards custom track

Promoters for HDHD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HDHD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HDHD2 Gene

47,107,403 bp from pter
47,150,520 bp from pter
43,118 bases
Minus strand

Genomic View for HDHD2 Gene

Genes around HDHD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDHD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDHD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDHD2 Gene

Proteins for HDHD2 Gene

  • Protein details for HDHD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Haloacid dehalogenase-like hydrolase domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K7T3
    • Q96NV4

    Protein attributes for HDHD2 Gene

    259 amino acids
    Molecular mass:
    28536 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HDHD2 Gene

    Alternative splice isoforms for HDHD2 Gene


neXtProt entry for HDHD2 Gene

Proteomics data for HDHD2 Gene at MOPED

Post-translational modifications for HDHD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HDHD2 Gene

Domains & Families for HDHD2 Gene

Protein Domains for HDHD2 Gene

Suggested Antigen Peptide Sequences for HDHD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HAD-like hydrolase superfamily.
  • Belongs to the HAD-like hydrolase superfamily.
genes like me logo Genes that share domains with HDHD2: view

No data available for Gene Families for HDHD2 Gene

Function for HDHD2 Gene

Gene Ontology (GO) - Molecular Function for HDHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016791 phosphatase activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HDHD2: view
genes like me logo Genes that share phenotypes with HDHD2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HDHD2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HDHD2 Gene

Localization for HDHD2 Gene

Subcellular locations from

Jensen Localization Image for HDHD2 Gene COMPARTMENTS Subcellular localization image for HDHD2 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HDHD2 Gene

Pathways & Interactions for HDHD2 Gene

SuperPathways for HDHD2 Gene

No Data Available

Interacting Proteins for HDHD2 Gene

Gene Ontology (GO) - Biological Process for HDHD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for HDHD2 Gene

Drugs & Compounds for HDHD2 Gene

No Compound Related Data Available

Transcripts for HDHD2 Gene

Unigene Clusters for HDHD2 Gene

Haloacid dehalogenase-like hydrolase domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HDHD2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: -
SP6: - - - -
SP7: - -
SP8: - - - -

Relevant External Links for HDHD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HDHD2 Gene

mRNA expression in normal human tissues for HDHD2 Gene

Protein differential expression in normal tissues from HIPED for HDHD2 Gene

This gene is overexpressed in Brain (6.6) and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HDHD2 Gene

SOURCE GeneReport for Unigene cluster for HDHD2 Gene Hs.465041

genes like me logo Genes that share expression patterns with HDHD2: view

Protein tissue co-expression partners for HDHD2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HDHD2 Gene

Orthologs for HDHD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HDHD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HDHD2 35
  • 92.02 (n)
  • 93.05 (a)
HDHD2 36
  • 92 (a)
(Canis familiaris)
Mammalia HDHD2 35
  • 93.95 (n)
  • 94.98 (a)
HDHD2 36
  • 57 (a)
(Mus musculus)
Mammalia Hdhd2 35
  • 86.36 (n)
  • 89.19 (a)
Hdhd2 16
Hdhd2 36
  • 88 (a)
(Pan troglodytes)
Mammalia HDHD2 35
  • 99.61 (n)
  • 99.23 (a)
HDHD2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Hdhd2 35
  • 84.59 (n)
  • 89.33 (a)
(Monodelphis domestica)
Mammalia HDHD2 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia HDHD2 36
  • 88 (a)
(Gallus gallus)
Aves HDHD2 35
  • 76.83 (n)
  • 83.01 (a)
HDHD2 36
  • 82 (a)
(Anolis carolinensis)
Reptilia HDHD2 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hdhd2 35
  • 66.8 (n)
  • 79.54 (a)
(Danio rerio)
Actinopterygii Dr.15003 35
hdhd2 35
  • 67.57 (n)
  • 77.22 (a)
hdhd2 36
  • 77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012227 35
  • 52.23 (n)
  • 49.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17294 35
  • 51.96 (n)
  • 51.01 (a)
CG17294 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea CELE_K08B12.3 35
  • 55.15 (n)
  • 53.66 (a)
K08B12.3 36
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
Species with no ortholog for HDHD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDHD2 Gene

Gene Tree for HDHD2 (if available)
Gene Tree for HDHD2 (if available)

Paralogs for HDHD2 Gene

Paralogs for HDHD2 Gene

(1) SIMAP similar genes for HDHD2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HDHD2: view

Variants for HDHD2 Gene

Sequence variations from dbSNP and Humsavar for HDHD2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs7230131 - 47,134,552(+) GTTTC(C/T)GCTCT reference, missense, utr-variant-5-prime
rs13547 -- 47,108,385(-) GCTAC(C/T)ACAGG utr-variant-3-prime
rs7232484 -- 47,138,624(+) GCGAA(A/G)GAAGG intron-variant
rs9950969 -- 47,135,686(+) ATCCT(A/T)AATAT intron-variant
rs5824649 -- 47,108,713(+) CCACA(-/G)CATGA downstream-variant-500B, reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for HDHD2 Gene

Variant ID Type Subtype PubMed ID
nsv9629 CNV Gain+Loss 18304495
nsv833640 CNV Loss 17160897
nsv909612 CNV Gain 21882294
esv271855 CNV Insertion 20981092
nsv909613 CNV Loss 21882294

Variation tolerance for HDHD2 Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HDHD2 Gene

Disorders for HDHD2 Gene

Relevant External Links for HDHD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HDHD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDHD2 Gene

Publications for HDHD2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for HDHD2 Gene

Sources for HDHD2 Gene