Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HDHD2 Gene

Aliases for HDHD2 Gene

  • Haloacid Dehalogenase-Like Hydrolase Domain Containing 2 2 3
  • Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 2 3
  • Epididymis Secretory Protein Li 301 3
  • 3110052N05Rik 3
  • HEL-S-301 3

External Ids for HDHD2 Gene

Previous GeneCards Identifiers for HDHD2 Gene

  • GC18M042887
  • GC18M044633
  • GC18M041481

Summaries for HDHD2 Gene

GeneCards Summary for HDHD2 Gene

HDHD2 (Haloacid Dehalogenase-Like Hydrolase Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is LHPP.

Gene Wiki entry for HDHD2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDHD2 Gene

Genomics for HDHD2 Gene

Regulatory Elements for HDHD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HDHD2 Gene

47,107,403 bp from pter
47,150,520 bp from pter
43,118 bases
Minus strand

Genomic View for HDHD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HDHD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDHD2 Gene

Proteins for HDHD2 Gene

  • Protein details for HDHD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Haloacid dehalogenase-like hydrolase domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K7T3
    • Q96NV4

    Protein attributes for HDHD2 Gene

    259 amino acids
    Molecular mass:
    28536 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HDHD2 Gene

    Alternative splice isoforms for HDHD2 Gene


neXtProt entry for HDHD2 Gene

Proteomics data for HDHD2 Gene at MOPED

Post-translational modifications for HDHD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HDHD2 Gene

Domains for HDHD2 Gene

Protein Domains for HDHD2 Gene

Suggested Antigen Peptide Sequences for HDHD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H0R4
  • Belongs to the HAD-like hydrolase superfamily.
genes like me logo Genes that share domains with HDHD2: view

No data available for Gene Families for HDHD2 Gene

Function for HDHD2 Gene

Gene Ontology (GO) - Molecular Function for HDHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019899 enzyme binding IPI 22939629
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HDHD2: view

Phenotypes for HDHD2 Gene

MGI mutant phenotypes for HDHD2:
inferred from 1 alleles
GenomeRNAi human phenotypes for HDHD2:
genes like me logo Genes that share phenotypes with HDHD2: view

Animal Model Products

CRISPR Products

miRNA for HDHD2 Gene

miRTarBase miRNAs that target HDHD2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HDHD2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HDHD2 Gene

Localization for HDHD2 Gene

Subcellular locations from

Jensen Localization Image for HDHD2 Gene COMPARTMENTS Subcellular localization image for HDHD2 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HDHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with HDHD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HDHD2 Gene

Pathways for HDHD2 Gene

SuperPathways for HDHD2 Gene

No Data Available

Interacting Proteins for HDHD2 Gene

Gene Ontology (GO) - Biological Process for HDHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HDHD2: view

No data available for Pathways by source for HDHD2 Gene

Transcripts for HDHD2 Gene

Unigene Clusters for HDHD2 Gene

Haloacid dehalogenase-like hydrolase domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HDHD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDHD2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: -
SP6: - - - -
SP7: - -
SP8: - - - -

Relevant External Links for HDHD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HDHD2 Gene

mRNA expression in normal human tissues for HDHD2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HDHD2 Gene

SOURCE GeneReport for Unigene cluster for HDHD2 Gene Hs.465041

genes like me logo Genes that share expressions with HDHD2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HDHD2 Gene

Orthologs for HDHD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HDHD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HDHD2 35
  • 99.61 (n)
  • 99.23 (a)
HDHD2 36
  • 99 (a)
(Bos Taurus)
Mammalia HDHD2 35
  • 92.02 (n)
  • 93.05 (a)
HDHD2 36
  • 92 (a)
(Canis familiaris)
Mammalia HDHD2 35
  • 93.95 (n)
  • 94.98 (a)
HDHD2 36
  • 57 (a)
(Mus musculus)
Mammalia Hdhd2 35
  • 86.36 (n)
  • 89.19 (a)
Hdhd2 16
Hdhd2 36
  • 88 (a)
(Monodelphis domestica)
Mammalia HDHD2 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia HDHD2 36
  • 88 (a)
(Rattus norvegicus)
Mammalia Hdhd2 35
  • 84.59 (n)
  • 89.33 (a)
(Gallus gallus)
Aves HDHD2 35
  • 76.83 (n)
  • 83.01 (a)
HDHD2 36
  • 82 (a)
(Anolis carolinensis)
Reptilia HDHD2 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hdhd2 35
  • 66.8 (n)
  • 79.54 (a)
(Danio rerio)
Actinopterygii Dr.15003 35
hdhd2 35
  • 67.57 (n)
  • 77.22 (a)
hdhd2 36
  • 77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012227 35
  • 52.23 (n)
  • 49.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17294 35
  • 51.96 (n)
  • 51.01 (a)
CG17294 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea CELE_K08B12.3 35
  • 55.15 (n)
  • 53.66 (a)
K08B12.3 36
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
Species with no ortholog for HDHD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDHD2 Gene

Gene Tree for HDHD2 (if available)
Gene Tree for HDHD2 (if available)

Paralogs for HDHD2 Gene

Paralogs for HDHD2 Gene

Selected SIMAP similar genes for HDHD2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HDHD2: view

Variants for HDHD2 Gene

Sequence variations from dbSNP and Humsavar for HDHD2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs13547 -- 47,108,385(-) GCTAC(C/T)ACAGG utr-variant-3-prime
rs1061752 -- 47,107,659(-) AACCC(A/C)CCAAA utr-variant-3-prime
rs1065170 -- 47,115,175(-) ATTGC(A/G)GGGCA missense, reference
rs1512237 -- 47,151,471(-) TTTTC(C/T)TTCAA upstream-variant-2KB
rs2117373 -- 47,145,463(+) AAAAG(A/G)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDHD2 Gene

Variant ID Type Subtype PubMed ID
nsv9629 CNV Gain+Loss 18304495
nsv833640 CNV Loss 17160897
nsv909612 CNV Gain 21882294
esv271855 CNV Insertion 20981092
nsv909613 CNV Loss 21882294

Relevant External Links for HDHD2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDHD2 Gene

Disorders for HDHD2 Gene

No disorders were found for HDHD2 Gene.

No data available for UniProtKB/Swiss-Prot for HDHD2 Gene

Publications for HDHD2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for HDHD2 Gene

Sources for HDHD2 Gene

Back to Top