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HDHD2 Gene

protein-coding   GIFtS: 49
GCID: GC18M044633

Haloacid Dehalogenase-Like Hydrolase Domain Containing 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Haloacid Dehalogenase-Like Hydrolase Domain Containing 21 2
3110052N05Rik2
HEL-S-3012
Epididymis Secretory Protein Li 3012
Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 22

External Ids:    HGNC: 253641   Entrez Gene: 840642   Ensembl: ENSG000001672207   UniProtKB: Q9H0R43   

Export aliases for HDHD2 gene to outside databases

Previous GC identifers: GC18M042887 GC18M041481


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HDHD2 Gene:
HDHD2 (haloacid dehalogenase-like hydrolase domain containing 2) is a protein-coding gene. An important paralog of this gene is LHPP.

Gene Wiki entry for HDHD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HDHD2 gene promoter:
         TBP   SRF (504 AA)   POU3F2   Gfi-1   Meis-1b   Pax-3   HSF2   Meis-1a   TGIF   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHDHD2 promoter sequence
   Search Chromatin IP Primers for HDHD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HDHD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

HDHD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDHD2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M044633:  view genomic region     (about GC identifiers)

Start:
44,633,774 bp from pter      End:
44,676,891 bp from pter
Size:
43,118 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HDHD2_HUMAN, Q9H0R4 (See protein sequence)
Recommended Name: Haloacid dehalogenase-like hydrolase domain-containing protein 2  
Size: 259 amino acids; 28536 Da
Cofactor: Binds 1 magnesium ion per subunit (By similarity)
1 PDB 3D structure from and Proteopedia for HDHD2:
3HLT (3D)    
Secondary accessions: A8K7T3 Q96NV4
Alternative splicing: 2 isoforms:  Q9H0R4-1   Q9H0R4-2   

Explore the universe of human proteins at neXtProt for HDHD2: NX_Q9H0R4

Explore proteomics data for HDHD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HDHD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115500.1  
    ENSEMBL proteins: 
     ENSP00000300605   ENSP00000466602   ENSP00000468067   ENSP00000466710   ENSP00000467309  
     ENSP00000467998   ENSP00000467775   ENSP00000465829   ENSP00000466923   ENSP00000465282  

    HDHD2 Human Recombinant Protein Products:

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    Novus Biologicals HDHD2 Proteins
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    ProSpec Recombinant Protein for HDHD2
    Cloud-Clone Corp. Proteins for HDHD2

     
    Search eBioscience for Proteins for HDHD2 

     
    antibodies-online proteins for HDHD2 (18 products) 

     
    Search antibodies-online for peptides for HDHD2

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    antibodies-online antibodies for HDHD2 (30 products) 

    HDHD2 Assay Products:

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    Cloud-Clone Corp. ELISAs for HDHD2
    Cloud-Clone Corp. CLIAs for HDHD2
    Search eBioscience for ELISAs for HDHD2 
    antibodies-online kits for HDHD2 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR023214 HAD-like_dom
     IPR006355 HAD-SF_hydro_IIA_hyp2
     IPR006357 HAD-SF_hydro_IIA
     IPR023215 NPhePase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H0R4

    ProtoNet protein and cluster: Q9H0R4

    UniProtKB/Swiss-Prot: HDHD2_HUMAN, Q9H0R4
    Similarity: Belongs to the HAD-like hydrolase superfamily


    Find genes that share domains with HDHD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019899enzyme binding IPI--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with HDHD2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HDHD2:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Hdhd2):
     mortality/aging 

    Find genes that share phenotypes with HDHD2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HDHD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HDHD2:
    hsa-mir-15a-5p (MIRT000857), hsa-mir-16-5p (MIRT000856)

    Block miRNA regulation of human, mouse, rat HDHD2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate HDHD2:
    hsa-miR-3607-3p hsa-miR-154 hsa-miR-544 hsa-miR-590-3p hsa-miR-4282 hsa-miR-664* hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidHDHD2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HDHD2
    Predesigned siRNA for gene silencing in human, mouse, rat HDHD2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: HDHD2 (NM_032124)
    Sino Biological Human cDNA Clone for HDHD2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDHD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDHD2
    Addgene plasmids for HDHD2 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDHD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with HDHD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HDHD2
    Interactions:

        Search GeneGlobe Interaction Network for HDHD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for HDHD2 (Q9H0R43 ENSP000003006054) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf55-LUC7L2Q9Y3833I2D: score=1 
    LUC7L2Q9Y3833I2D: score=1 
    MGST2Q997353, ENSP000002654984I2D: score=1 STRING: ENSP00000265498
    BAI2O602413, ENSP000003627624I2D: score=1 STRING: ENSP00000362762
    CFDP007463, ENSP000003321394I2D: score=1 STRING: ENSP00000332139
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with HDHD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HDHD2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HDHD2 gene: 
    NM_032124.4  

    Unigene Cluster for HDHD2:

    Haloacid dehalogenase-like hydrolase domain containing 2
    Hs.465041  [show with all ESTs]
    Unigene Representative Sequence: BX537623
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300605(uc002lcs.3 uc002lct.3) ENST00000588183 ENST00000588861
    ENST00000587841 ENST00000590815 ENST00000591480 ENST00000586546 ENST00000590481
    ENST00000588940 ENST00000591268 ENST00000587388 ENST00000592591 ENST00000591671

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HDHD2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate HDHD2:
    hsa-miR-3607-3p hsa-miR-154 hsa-miR-544 hsa-miR-590-3p hsa-miR-4282 hsa-miR-664* hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidHDHD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HDHD2
    Predesigned siRNA for gene silencing in human, mouse, rat HDHD2
    Clone
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    OriGene clones in human, mouse for HDHD2 (see all 7)
    OriGene ORF clones in mouse, rat for HDHD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HDHD2 (NM_032124)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDHD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDHD2
    Addgene plasmids for HDHD2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HDHD2
    OriGene qSTAR qPCR primer pairs in human, mouse for HDHD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HDHD2
      QuantiTect SYBR Green Assays in human, mouse, rat HDHD2
      QuantiFast Probe-based Assays in human, mouse, rat HDHD2

    Additional mRNA sequence: 

    AK054590.1 AK090802.1 AK292098.1 AL136681.1 BC011894.2 BC033031.1 BC038100.2 BX537623.1 
    CR533487.1 

    16 DOTS entries:

    DT.315066  DT.100785596  DT.101983479  DT.121102310  DT.100722964  DT.100717155  DT.121102334  DT.100765033 
    DT.100657072  DT.121102295  DT.121102298  DT.121102354  DT.305982  DT.40312820  DT.95072365  DT.95077692 

    Selected AceView cDNA sequences (see all 521):

    AI271963 BX282014 BQ425962 BM670439 NM_032124 BM970485 AW130276 BX108615 
    CR626039 AW612301 BF447814 AW665087 CB215090 CD242373 AW058520 Z40188 
    AW189463 AK054590 BQ232756 CR596209 BU743002 BF244066 BM724496 AA953979 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HDHD2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8a · 8b
    SP1:                          -                       -                                               -               
    SP2:                                                  -                                               -               
    SP3:                          -                       -                                                               
    SP4:                                                  -                                                               
    SP5:                                                  -                                                               


    ECgene alternative splicing isoforms for HDHD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HDHD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAACCCAC
    HDHD2 Expression
    About this image

    HDHD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HDHD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465041
        Custom PCR Arrays for HDHD2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDHD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HDHD2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hdhd21 , 5 haloacid dehalogenase-like hydrolase domain containing more1, 5 86.36(n)1
    89.19(a)1
      18 (51.98 cM)5
    769871  NM_029826.21  NP_084102.11 
     769301265 
    chicken
    (Gallus gallus)
    Aves HDHD21 haloacid dehalogenase-like hydrolase domain containing more 76.83(n)
    83.01(a)
      416385  XM_414700.4  XP_414700.4 
    lizard
    (Anolis carolinensis)
    Reptilia HDHD26
    haloacid dehalogenase-like hydrolase domain contai...
    82(a)
    1 ↔ 1
    1(34345561-34359986)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hdhd21 haloacid dehalogenase-like hydrolase domain containing more 66.8(n)
    79.54(a)
      100145104  NM_001126620.1  NP_001120092.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.150032 Transcribed sequence with moderate similarity to protein more 76.17(n)    BU744180.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG172941 CG17294 51.96(n)
    51.01(a)
      34155  NM_135375.4  NP_609219.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_K08B12.31 CELE_K08B12.3 55.15(n)
    53.66(a)
      187136  NM_072196.1  NP_504597.1 


    ENSEMBL Gene Tree for HDHD2 (if available)
    TreeFam Gene Tree for HDHD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HDHD2 gene
    LHPP2  
    1 SIMAP similar gene for HDHD2 using alignment to 6 protein entries:     HDHD2_HUMAN (see all proteins):
    LHPP

    Find genes that share paralogs with HDHD2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HDHD2 (see all 860)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs72429781,2
    C,F,H--44629325(+) ACTGTG/TAAATG 1 -- int135Minor allele frequency- N:0.00NS EA NA WA 3402
    rs1469273211,2
    --44629411(+) CTTAAC/TATATA 1 -- int10--------
    rs1925825571,2
    --44629427(+) TGCACA/GTAATG 1 -- int10--------
    rs758006241,2
    C,F--44629506(+) GAGGTG/CAGGTG 1 -- int13Minor allele frequency- C:0.09WA NA EA 358
    rs1141085431,2
    C,F--44629925(+) CTTTAT/CTTTGG 1 -- ut311Minor allele frequency- C:0.07WA 118
    rs1164338031,2
    C,F--44629959(+) TCCATG/TCTACA 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs739542321,2
    C,F--44630001(+) CAAGTG/CCATAA 1 -- ut312Minor allele frequency- C:0.04WA 120
    rs1840384161,2
    --44630051(+) CCATAC/GTGTCA 1 -- ut310--------
    rs118723501,2
    C,F,H--44630192(+) AATGTC/TTAATT 1 -- ut312Minor allele frequency- T:0.50NA 4
    rs729054441,2
    C,F--44630215(+) AAATAC/TTGATA 1 -- ut311Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for HDHD2 (44633774 - 44676891 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HDHD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv271855CNV Insertion20981092
    nsv909613CNV Loss21882294
    nsv833640CNV Loss17160897
    nsv909612CNV Gain21882294
    nsv9629CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HDHD2
    DNA2.0 Custom Variant and Variant Library Synthesis for HDHD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HDHD2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with HDHD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84064 HGNC: 25364 AceView: IER3IP1andHDHD2 Ensembl:ENSG00000167220 euGenes: HUgn84064
    ECgene: HDHD2 H-InvDB: HDHD2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HDHD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HDHD2 gene:
    Search GeneIP for patents involving HDHD2

    GeneCards and IP:
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