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HDHD2 Gene(Protein Coding)

Haloacid Dehalogenase Like Hydrolase Domain Containing 2

GCID:
GC18M047107
GIFtS:
50
Genes Participants
UDN Logo

Aliases for HDHD2 Gene

Aliases for HDHD2 Gene

  • Haloacid Dehalogenase Like Hydrolase Domain Containing 2 2 3 5
  • Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 2 3
  • Haloacid Dehalogenase-Like Hydrolase Domain Containing 2 2
  • Epididymis Secretory Protein Li 301 3
  • 3110052N05Rik 3
  • HEL-S-301 3

External Ids for HDHD2 Gene

Previous GeneCards Identifiers for HDHD2 Gene

  • GC18M042887
  • GC18M044633
  • GC18M041481

Summaries for HDHD2 Gene

GeneCards Summary for HDHD2 Gene

HDHD2 (Haloacid Dehalogenase Like Hydrolase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include enzyme binding. An important paralog of this gene is LHPP.

Gene Wiki entry for HDHD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDHD2 Gene

Genomics for HDHD2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for HDHD2 Gene

Enhancers for HDHD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G047174 1.1 ENCODE 23.8 -25.3 -25305 2.4 FOXA2 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF143 ZNF207 HDHD2 IER3IP1 KATNAL2 ENSG00000267228
GH18G047184 0.9 ENCODE 21.4 -34.4 -34394 0.5 HDAC1 CBX3 RB1 CHAMP1 ZNF766 ZNF366 ELK1 GATA2 CBX5 SIRT6 HDHD2 IER3IP1 KATNAL2 GC18M047235 RNU6-1131P
GH18G048107 1.1 ENCODE dbSUPER 13.5 -957.2 -957212 0.9 NFIB ZNF473 KLF17 ZNF366 SCRT2 EGR2 ZNF263 SP3 ZNF680 YY2 HDHD2 CTIF GC18P048133 LOC105372101
GH18G047149 1.1 ENCODE 12.8 -0.1 -52 2.5 PKNOX1 FOXA2 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SP3 HDHD2 IER3IP1 KATNAL2 ENSG00000267228
GH18G047243 1.4 VISTA 9.3 -93.9 -93887 1.0 ZNF530 EP300 ENSG00000267724 HDHD2 PIAS2 GC18P047244 GC18M047235 RNU6-1131P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HDHD2 on UCSC Golden Path with GeneCards custom track

Promoters for HDHD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000102948 220 1801 PKNOX1 FOXA2 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SP3

Transcription factor binding sites by QIAGEN in the HDHD2 gene promoter:

Genomic Location for HDHD2 Gene

Chromosome:
18
Start:
47,107,403 bp from pter
End:
47,150,520 bp from pter
Size:
43,118 bases
Orientation:
Minus strand

Genomic View for HDHD2 Gene

Genes around HDHD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDHD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDHD2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HDHD2 Gene

Proteins for HDHD2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HDHD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0R4-HDHD2_HUMAN
    Recommended name:
    Haloacid dehalogenase-like hydrolase domain-containing protein 2
    Protein Accession:
    Q9H0R4
    Secondary Accessions:
    • A8K7T3
    • Q96NV4

    Protein attributes for HDHD2 Gene

    Size:
    259 amino acids
    Molecular mass:
    28536 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HDHD2 Gene

    Alternative splice isoforms for HDHD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDHD2 Gene

Protein Expression for HDHD2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HDHD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HDHD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HDHD2 Gene

Domains & Families for HDHD2 Gene

Gene Families for HDHD2 Gene

HGNC:

Protein Domains for HDHD2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HDHD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0R4

UniProtKB/Swiss-Prot:

HDHD2_HUMAN :
  • Belongs to the HAD-like hydrolase superfamily.
Family:
  • Belongs to the HAD-like hydrolase superfamily.
genes like me logo Genes that share domains with HDHD2: view

Function for HDHD2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Gene Ontology (GO) - Molecular Function for HDHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016791 phosphatase activity IBA --
GO:0019899 enzyme binding IPI 22939629
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HDHD2: view
genes like me logo Genes that share phenotypes with HDHD2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HDHD2

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HDHD2 Gene

Localization for HDHD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDHD2 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HDHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with HDHD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HDHD2 Gene

Pathways & Interactions for HDHD2 Gene

SuperPathways for HDHD2 Gene

PathCards logo More details on SuperPathways for HDHD2
No Data Available

Gene Ontology (GO) - Biological Process for HDHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016311 dephosphorylation IBA --
genes like me logo Genes that share ontologies with HDHD2: view

No data available for Pathways by source and SIGNOR curated interactions for HDHD2 Gene

Drugs & Compounds for HDHD2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for HDHD2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HDHD2 Gene

(8) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(521) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HDHD2 Gene

Haloacid dehalogenase-like hydrolase domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDHD2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: -
SP6: - - - -
SP7: - -
SP8: - - - -
SP9:

Relevant External Links for HDHD2 Gene

GeneLoc Exon Structure for
HDHD2
ECgene alternative splicing isoforms for
HDHD2

Expression for HDHD2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HDHD2 Gene

mRNA expression in normal human tissues for HDHD2 Gene
mRNA expression by BioGPS for HDHD2 GenemRNA expression by GTEx for HDHD2 Gene

Protein differential expression in normal tissues from HIPED for HDHD2 Gene

This gene is overexpressed in Brain (6.6) and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HDHD2 Gene



Protein tissue co-expression partners for HDHD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HDHD2 Gene:

HDHD2

SOURCE GeneReport for Unigene cluster for HDHD2 Gene:

Hs.465041

Evidence on tissue expression from TISSUES for HDHD2 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with HDHD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDHD2 Gene

Orthologs for HDHD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HDHD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia HDHD2 34 35
  • 99.61 (n)
dog
(Canis familiaris)
 Mammalia HDHD2 34 35
  • 93.95 (n)
cow
(Bos Taurus)
 Mammalia HDHD2 34 35
  • 92.02 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia HDHD2 35
  • 88 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Hdhd2 34 16 35
  • 86.36 (n)
rat
(Rattus norvegicus)
 Mammalia Hdhd2 34
  • 84.59 (n)
oppossum
(Monodelphis domestica)
 Mammalia HDHD2 35
  • 79 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves HDHD2 34 35
  • 76.83 (n)
lizard
(Anolis carolinensis)
 Reptilia HDHD2 35
  • 82 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia hdhd2 34
  • 66.8 (n)
zebrafish
(Danio rerio)
 Actinopterygii hdhd2 34 35
  • 67.57 (n)
Dr.15003 34
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP012227 34
  • 52.23 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG17294 34 35
  • 51.96 (n)
worm
(Caenorhabditis elegans)
 Secernentea CELE_K08B12.3 34
  • 55.15 (n)
K08B12.3 35
  • 51 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 48 (a)
 OneToOne
Species where no ortholog for HDHD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDHD2 Gene

ENSEMBL:
Gene Tree for HDHD2 (if available)
TreeFam:
Gene Tree for HDHD2 (if available)

Paralogs for HDHD2 Gene

Paralogs for HDHD2 Gene

(1) SIMAP similar genes for HDHD2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HDHD2: view

Variants for HDHD2 Gene

Sequence variations from dbSNP and Humsavar for HDHD2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000057365 -- 47,110,224(+) CATCA(G/T)GGTGG intron-variant, utr-variant-3-prime
rs1000079178 -- 47,120,108(+) ACCAG(C/T)TGCAT intron-variant
rs1000104515 -- 47,137,806(+) AAATT(A/G)CTCAA intron-variant
rs1000132873 -- 47,119,866(+) CAGAA(C/T)GGGTG intron-variant
rs1000185969 -- 47,113,644(+) ATGAT(G/T)AATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDHD2 Gene

Variant ID Type Subtype PubMed ID
esv3307581 CNV mobile element insertion 20981092
esv3419585 CNV insertion 20981092
esv3642451 CNV gain 21293372
esv3642452 CNV gain 21293372
nsv576819 CNV loss 21841781
nsv833640 CNV loss 17160897
nsv960277 CNV duplication 23825009
nsv9629 CNV gain+loss 18304495

Variation tolerance for HDHD2 Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HDHD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HDHD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDHD2 Gene

Disorders for HDHD2 Gene

Relevant External Links for HDHD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HDHD2

No disorders were found for HDHD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDHD2 Gene

Publications for HDHD2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64

Products for HDHD2 Gene

  • Addgene plasmids for HDHD2

Sources for HDHD2 Gene

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