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Aliases for HDGFRP3 Gene

Aliases for HDGFRP3 Gene

  • Hepatoma-Derived Growth Factor, Related Protein 3 3
  • Hepatoma-Derived Growth Factor 2 3 4
  • HDGF-2 3 4
  • HDGF2 3 4
  • HRP-3 3 4
  • Hepatoma-Derived Growth Factor-Related Protein 3 3
  • CGI-142 3

External Ids for HDGFRP3 Gene

Previous GeneCards Identifiers for HDGFRP3 Gene

  • GC15M079733
  • GC15M076838
  • GC15M081385
  • GC15M081526
  • GC15M081597
  • GC15M083806
  • GC15M060070
  • GC15M083784

Summaries for HDGFRP3 Gene

GeneCards Summary for HDGFRP3 Gene

HDGFRP3 (Hepatoma-Derived Growth Factor, Related Protein 3) is a Protein Coding gene. GO annotations related to this gene include growth factor activity. An important paralog of this gene is HDGFL1.

UniProtKB/Swiss-Prot for HDGFRP3 Gene

  • Enhances DNA synthesis and may play a role in cell proliferation.

Gene Wiki entry for HDGFRP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDGFRP3 Gene

Genomics for HDGFRP3 Gene

Regulatory Elements for HDGFRP3 Gene

Genomic Location for HDGFRP3 Gene

83,112,738 bp from pter
83,208,018 bp from pter
95,281 bases
Minus strand

Genomic View for HDGFRP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HDGFRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDGFRP3 Gene

Proteins for HDGFRP3 Gene

  • Protein details for HDGFRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatoma-derived growth factor-related protein 3
    Protein Accession:
    Secondary Accessions:

    Protein attributes for HDGFRP3 Gene

    203 amino acids
    Molecular mass:
    22620 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HDGFRP3 Gene

Proteomics data for HDGFRP3 Gene at MOPED

Post-translational modifications for HDGFRP3 Gene

  • Ubiquitination at Lys66
  • Modification sites at PhosphoSitePlus

Other Protein References for HDGFRP3 Gene

No data available for DME Specific Peptides for HDGFRP3 Gene

Domains for HDGFRP3 Gene

Protein Domains for HDGFRP3 Gene


Suggested Antigen Peptide Sequences for HDGFRP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y3E1
  • Contains 1 PWWP domain.
  • Belongs to the HDGF family.
genes like me logo Genes that share domains with HDGFRP3: view

No data available for Gene Families for HDGFRP3 Gene

Function for HDGFRP3 Gene

Molecular function for HDGFRP3 Gene

UniProtKB/Swiss-Prot Function: Enhances DNA synthesis and may play a role in cell proliferation.

Gene Ontology (GO) - Molecular Function for HDGFRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with HDGFRP3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HDGFRP3 Gene

Localization for HDGFRP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDGFRP3 Gene

Subcellular locations from

Jensen Localization Image for HDGFRP3 Gene COMPARTMENTS Subcellular localization image for HDGFRP3 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HDGFRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10581169
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HDGFRP3: view

Pathways for HDGFRP3 Gene

SuperPathways for HDGFRP3 Gene

No Data Available

Interacting Proteins for HDGFRP3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000299633 Q9Y3E1-HDGR3_HUMAN for HDGFRP3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for HDGFRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation NAS 10581169
genes like me logo Genes that share ontologies with HDGFRP3: view

No data available for Pathways by source for HDGFRP3 Gene

Transcripts for HDGFRP3 Gene

Unigene Clusters for HDGFRP3 Gene

Hepatoma-derived growth factor, related protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HDGFRP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDGFRP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -

Relevant External Links for HDGFRP3 Gene

GeneLoc Exon Structure for

Expression for HDGFRP3 Gene

mRNA expression in normal human tissues for HDGFRP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HDGFRP3 Gene

SOURCE GeneReport for Unigene cluster for HDGFRP3 Gene Hs.513954

mRNA Expression by UniProt/SwissProt for HDGFRP3 Gene

Tissue specificity: Detected in testis, heart, spinal cord and brain.
genes like me logo Genes that share expressions with HDGFRP3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HDGFRP3 Gene

Orthologs for HDGFRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HDGFRP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
  • 100 (n)
  • 100 (a)
(Bos Taurus)
Mammalia HDGFRP3 35
  • 93.92 (n)
  • 99.51 (a)
  • 99 (a)
(Canis familiaris)
Mammalia -- 36
  • 99 (a)
  • 94.54 (n)
  • 98.87 (a)
(Mus musculus)
Mammalia Hdgfrp3 35
  • 94.39 (n)
  • 97.52 (a)
Hdgfrp3 16
Hdgfrp3 36
  • 98 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
(Rattus norvegicus)
Mammalia Hdgfrp3 35
  • 94.22 (n)
  • 98.02 (a)
(Gallus gallus)
Aves -- 36
  • 82 (a)
  • 87.5 (n)
  • 97.16 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hdgfrp3 35
  • 81.02 (n)
  • 87.62 (a)
(Danio rerio)
Actinopterygii CABZ01088864.1 36
  • 100 (a)
hdgfrp3 35
  • 68.03 (n)
  • 76.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7946 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea C06A5.3 36
  • 6 (a)
Species with no ortholog for HDGFRP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDGFRP3 Gene

Gene Tree for HDGFRP3 (if available)
Gene Tree for HDGFRP3 (if available)

Paralogs for HDGFRP3 Gene

Paralogs for HDGFRP3 Gene

Selected SIMAP similar genes for HDGFRP3 Gene using alignment to 4 proteins: Pseudogenes for HDGFRP3 Gene

genes like me logo Genes that share paralogs with HDGFRP3: view

Variants for HDGFRP3 Gene

Sequence variations from dbSNP and Humsavar for HDGFRP3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1903 -- 83,138,221(+) TTTNT(G/T)TTTTT utr-variant-3-prime, intron-variant
rs965263 -- 83,165,179(-) ggttc(A/C)ccact intron-variant
rs965264 -- 83,164,829(-) CTTGA(A/G)ACATT intron-variant
rs1112404 -- 83,173,728(+) CTCAA(A/C)TTTTC intron-variant
rs1533907 -- 83,178,536(+) gtgca(C/T)gcctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDGFRP3 Gene

Variant ID Type Subtype PubMed ID
nsv94888 CNV Insertion 16902084
esv2478815 CNV Deletion 19546169

Relevant External Links for HDGFRP3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDGFRP3 Gene

Disorders for HDGFRP3 Gene

(1) University of Copenhagen DISEASES for HDGFRP3 Gene

genes like me logo Genes that share disorders with HDGFRP3: view

No data available for UniProtKB/Swiss-Prot for HDGFRP3 Gene

Publications for HDGFRP3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus. (PMID: 10581169) Ikegame K. … Nakamura H. (Biochem. Biophys. Res. Commun. 1999) 3 4
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase. (PMID: 15371438) Cherepanov P. … Engelman A. (J. Biol. Chem. 2004) 3

Products for HDGFRP3 Gene

Sources for HDGFRP3 Gene

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