HDGFRP3 Gene
protein-coding GIFtS: 41
GCID: GC15M083784
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HDGFRP3
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Aliases
for HDGFRP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hepatoma-Derived Growth Factor 22 3 | | HDGF-22 3 | | HDGF22 3 | | HRP-32 3 | | Hepatoma-Derived Growth Factor, Related Protein 32 | | Hepatoma-Derived Growth Factor-Related Protein 32 |
Export aliases for HDGFRP3 gene to outside databasesPrevious GC identifers: GC15M079733 GC15M076838 GC15M081385 GC15M081526 GC15M081597 GC15M083806 GC15M060070 |
Summaries
for HDGFRP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HDGR3_HUMAN, Q9Y3E1Function: Enhances DNA synthesis and may play a role in cell proliferation
Gene Wiki entry for HDGFRP3
|
Genomic Views
for HDGFRP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_077661.3
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HDGFRP3 gene promoter:
STAT5B RFX1 POU3F1 STAT6 RelA NF-kappaB NF-kappaB1 Pax-4a E47 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for HDGFRP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDGFRP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q25.2 Ensembl cytogenetic band: 15q25.2 HDGFRP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M083784: view genomic region
(about GC identifiers)
Start:
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83,784,320 bp from pter |
End:
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83,876,770 bp from pter |
Size:
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92,451 bases |
Orientation:
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minus strand |
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Proteins
for HDGFRP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HDGR3_HUMAN, Q9Y3E1 (See
protein sequence)Recommended Name: Hepatoma-derived growth factor-related protein 3 Size: 203 amino acids; 22620 Da
Subcellular location: NucleusExplore the universe of human proteins at neXtProt for HDGFRP3: NX_Q9Y3E1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3E1
HDGFRP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057157.1
ENSEMBL proteins: ENSP00000455388 ENSP00000299633 ENSP00000455425 ENSP00000457346 ENSP00000456699
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
HDGFRP3 for ontologies About GeneDecksing
HDGFRP3 Antibody Products:
Assay Products for HDGFRP3: |
Protein
Domains /
Families
for HDGFRP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HDGFRP3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y3E1ProtoNet protein and cluster: Q9Y3E1 1 Blocks protein family: IPB000313 PWWP domain
UniProtKB/Swiss-Prot: HDGR3_HUMAN, Q9Y3E1Similarity: Belongs to the HDGF familySimilarity: Contains 1 PWWP domain |
Function
for HDGFRP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HDGR3_HUMAN, Q9Y3E1Function: Enhances DNA synthesis and may play a role in cell proliferation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDGFRP3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDGFRP3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HDGFRP3 (NM_016073) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HDGFRP3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDGFRP3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDGFRP3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008083 | growth factor activity |
IEA | -- |
HDGFRP3 for ontologies About GeneDecksing
|
Pathways & Interactions
for HDGFRP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HDGFRP3
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/8 Interacting proteins for HDGFRP3 (Q9Y3E13 ENSP000002996334) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
HDGFRP3 for ontologies About GeneDecksing
|
Drugs & Compounds
for HDGFRP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HDGFRP3
Search CenterWatch for drugs/clinical trials and news about HDGFRP3 / HDGR3
|
Transcripts
for HDGFRP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HDGFRP3 gene: NM_016073.3 Unigene Cluster for HDGFRP3: Hepatoma-derived growth factor, related protein 3 Hs.513954 [show with all ESTs]Unigene Representative Sequence: AL1331026 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000568294 ENST00000299633(uc002bjs.1) ENST00000563790 ENST00000562702
ENST00000568129 ENST00000563404
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDGFRP3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDGFRP3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HDGFRP3 (NM_016073) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HDGFRP3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDGFRP3 |
Additional cDNA sequence: AB029156.1 AF110642.1 AF151900.1 AK001280.1 AL109689.1 AL109779.1 AL133102.1 BC015483.1 BC040554.1 HQ234314.1 13 DOTS entries: DT.99972920 DT.312973 DT.100886600 DT.92442881 DT.121066699 DT.92442891 DT.100886581 DT.100886586 DT.100886588 DT.92012097 DT.92442883 DT.95278051 DT.97783410 24/185 AceView cDNA sequences (see all 185): AL109689 CB215502 BX113376 BG259778 BM975396 AA446692 BC015483 CB135419 BE220848 BX283676 AL520469 AW864388 BQ188454 AA776034 BM464467 CR604509 AI027718 AL133102 AL520288 BM457409 CR598906 AL109779 H97413 BU179069
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for HDGFRP3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 |
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| SP1: | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | |
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Expression
for HDGFRP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HDGFRP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HDGFRP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HDGFRP3
SOURCE GeneReport for Unigene cluster: Hs.513954
UniProtKB/Swiss-Prot: HDGR3_HUMAN, Q9Y3E1Tissue specificity: Detected in testis, heart, spinal cord and brain
SABiosciences Custom PCR Arrays for HDGFRP3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HDGFRP3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HDGFRP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDGFRP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDGFRP3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDGFRP3 |
Orthologs
for HDGFRP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HDGFRP3 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for HDGFRP3 (if available)
TreeFam Gene Tree for HDGFRP3 (if available) |
Paralogs
for HDGFRP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HDGFRP3 gene
- HDGF2 PSIP12 HDGFL12 HDGFRP22
4 SIMAP similar genes for HDGFRP3 using alignment to 4 protein entries: HDGR3_HUMAN (see all proteins):PSIP1 HDGF HDGFRP2 HDGFL1
HDGFRP3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for HDGFRP3
PGOHUM00000262826
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Genomic Variants
for HDGFRP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HDGFRP3 (83784320 - 83876770 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HDGFRP3
1 CNV: 102147 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HDGFRP3 |
|
Disorders
/ Diseases
for HDGFRP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HDGFRP3 for disorders About GeneDecksing
5  diseases for HDGFRP3: About MalaCardscongenital diaphragmatic hernia mantle cell lymphoma cryptorchidism hernia
neuronitis
1 disease from the University of Copenhagen DISEASES database for HDGFRP3:Congenital diaphragmatic hernia Export disorders for HDGFRP3 gene to outside databases
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Publications
for HDGFRP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HDGFRP3 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with HDGFRP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus. (PubMed id 10581169)1, 2 Ikegame K.... Nakamura H. (1999)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Hepatoma-derived growth factor-related protein-3 inte racts with microtubules and promotes neurite outgrowth in mouse cortical neuron s. (PubMed id 19237540)1 El-Tahir H.M....Franken S. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. (PubMed id 16337983)1 Vandegraaff N....Engelman A. (2006)
- High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
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External Searches for HDGFRP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HDGFRP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HDGFRP3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HDGFRP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HDGFRP3 gene:
Search GeneIP for patents involving HDGFRP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HDGFRP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HDGFRP3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDGFRP3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HDGFRP3 | | | OriGene Protein Over-expression Lysate for HDGFRP3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HDGFRP3 | | OriGene 3'-UTR Clone for HDGFRP3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDGFRP3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDGFRP3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HDGFRP3 | | OriGene Custom Protein Services for HDGFRP3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HDGFRP3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HDGFRP3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDGFRP3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDGFRP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDGFRP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDGFRP3 |
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| | | | Search Tocris compounds for HDGFRP3 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDGFRP3 |
|  |  |  | | | | Search ThermoFisher Antibodies for HDGFRP3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDGFRP3 |
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