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Aliases for HDGFRP3 Gene

Aliases for HDGFRP3 Gene

  • Hepatoma-Derived Growth Factor, Related Protein 3 3
  • Hepatoma-Derived Growth Factor 2 3 4
  • HDGF-2 3 4
  • HDGF2 3 4
  • HRP-3 3 4
  • Hepatoma-Derived Growth Factor-Related Protein 3 5
  • RP11-382A20.3 5
  • CGI-142 3

External Ids for HDGFRP3 Gene

Previous GeneCards Identifiers for HDGFRP3 Gene

  • GC15M079733
  • GC15M076838
  • GC15M081385
  • GC15M081526
  • GC15M081597
  • GC15M083806
  • GC15M060070
  • GC15M083784

Summaries for HDGFRP3 Gene

GeneCards Summary for HDGFRP3 Gene

HDGFRP3 (Hepatoma-Derived Growth Factor, Related Protein 3) is a Protein Coding gene. GO annotations related to this gene include growth factor activity. An important paralog of this gene is PSIP1.

UniProtKB/Swiss-Prot for HDGFRP3 Gene

  • Enhances DNA synthesis and may play a role in cell proliferation.

Gene Wiki entry for HDGFRP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDGFRP3 Gene

Genomics for HDGFRP3 Gene

Regulatory Elements for HDGFRP3 Gene

Promoters for HDGFRP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HDGFRP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HDGFRP3 Gene

Chromosome:
15
Start:
83,112,738 bp from pter
End:
83,208,018 bp from pter
Size:
95,281 bases
Orientation:
Minus strand

Genomic View for HDGFRP3 Gene

Genes around HDGFRP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDGFRP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDGFRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDGFRP3 Gene

Proteins for HDGFRP3 Gene

  • Protein details for HDGFRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3E1-HDGR3_HUMAN
    Recommended name:
    Hepatoma-derived growth factor-related protein 3
    Protein Accession:
    Q9Y3E1

    Protein attributes for HDGFRP3 Gene

    Size:
    203 amino acids
    Molecular mass:
    22620 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HDGFRP3 Gene

Proteomics data for HDGFRP3 Gene at MOPED

Post-translational modifications for HDGFRP3 Gene

  • Ubiquitination at Lys 66
  • Modification sites at PhosphoSitePlus

Other Protein References for HDGFRP3 Gene

Antibody Products

No data available for DME Specific Peptides for HDGFRP3 Gene

Domains & Families for HDGFRP3 Gene

Protein Domains for HDGFRP3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HDGFRP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3E1

UniProtKB/Swiss-Prot:

HDGR3_HUMAN :
  • Contains 1 PWWP domain.
  • Belongs to the HDGF family.
Domain:
  • Contains 1 PWWP domain.
Family:
  • Belongs to the HDGF family.
genes like me logo Genes that share domains with HDGFRP3: view

No data available for Gene Families for HDGFRP3 Gene

Function for HDGFRP3 Gene

Molecular function for HDGFRP3 Gene

UniProtKB/Swiss-Prot Function:
Enhances DNA synthesis and may play a role in cell proliferation.

Phenotypes for HDGFRP3 Gene

genes like me logo Genes that share phenotypes with HDGFRP3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HDGFRP3 Gene

Localization for HDGFRP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDGFRP3 Gene

Gene Ontology (GO) - Cellular Components for HDGFRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with HDGFRP3: view

No data available for Subcellular locations from COMPARTMENTS for HDGFRP3 Gene

Pathways & Interactions for HDGFRP3 Gene

SuperPathways for HDGFRP3 Gene

No Data Available

Interacting Proteins for HDGFRP3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000299633%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000339007%0d%0a9606.ENSP00000300086%0d%0a
Selected Interacting proteins: Q9Y3E1-HDGR3_HUMAN ENSP00000299633 for HDGFRP3 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for HDGFRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031175 neuron projection development IEA,ISS --
GO:0046785 microtubule polymerization IEA,ISS --
genes like me logo Genes that share ontologies with HDGFRP3: view

No data available for Pathways by source and SIGNOR curated interactions for HDGFRP3 Gene

Drugs & Compounds for HDGFRP3 Gene

No Compound Related Data Available

Transcripts for HDGFRP3 Gene

Unigene Clusters for HDGFRP3 Gene

Hepatoma-derived growth factor, related protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDGFRP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2:
SP3:

Relevant External Links for HDGFRP3 Gene

GeneLoc Exon Structure for
HDGFRP3

Expression for HDGFRP3 Gene

mRNA expression in normal human tissues for HDGFRP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HDGFRP3 Gene

This gene is overexpressed in Retina (11.9) and Fetal Brain (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HDGFRP3 Gene



SOURCE GeneReport for Unigene cluster for HDGFRP3 Gene Hs.513954

mRNA Expression by UniProt/SwissProt for HDGFRP3 Gene

Q9Y3E1-HDGR3_HUMAN
Tissue specificity: Detected in testis, heart, spinal cord and brain.
genes like me logo Genes that share expression patterns with HDGFRP3: view

Protein tissue co-expression partners for HDGFRP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HDGFRP3 Gene

Orthologs for HDGFRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HDGFRP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HDGFRP3 35
  • 93.92 (n)
  • 99.51 (a)
HDGFRP3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HDGFRP3 35
  • 94.54 (n)
  • 98.87 (a)
-- 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hdgfrp3 35
  • 94.39 (n)
  • 97.52 (a)
Hdgfrp3 16
Hdgfrp3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HDGFRP3 35
  • 100 (n)
  • 100 (a)
-- 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hdgfrp3 35
  • 94.22 (n)
  • 98.02 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves HDGFRP3 35
  • 87.5 (n)
  • 97.16 (a)
-- 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdgfrp3 35
  • 81.02 (n)
  • 87.62 (a)
zebrafish
(Danio rerio)
Actinopterygii hdgfrp3 35
  • 68.03 (n)
  • 76.02 (a)
CABZ01088864.1 36
  • 100 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7946 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06A5.3 36
  • 6 (a)
OneToMany
Species with no ortholog for HDGFRP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDGFRP3 Gene

ENSEMBL:
Gene Tree for HDGFRP3 (if available)
TreeFam:
Gene Tree for HDGFRP3 (if available)

Paralogs for HDGFRP3 Gene

Paralogs for HDGFRP3 Gene

(4) SIMAP similar genes for HDGFRP3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for HDGFRP3 Gene

genes like me logo Genes that share paralogs with HDGFRP3: view

Variants for HDGFRP3 Gene

Sequence variations from dbSNP and Humsavar for HDGFRP3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs965263 -- 83,165,179(-) ggttc(A/C)ccact intron-variant
rs965264 -- 83,164,829(-) CTTGA(A/G)ACATT intron-variant
rs1112404 -- 83,173,728(+) CTCAA(A/C)TTTTC intron-variant
rs2385705 -- 83,194,415(+) GTAGA(C/G)TTATT intron-variant
rs2123160 -- 83,145,818(-) TCTTA(A/G)AAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDGFRP3 Gene

Variant ID Type Subtype PubMed ID
nsv94888 CNV Insertion 16902084
esv2478815 CNV Deletion 19546169

Variation tolerance for HDGFRP3 Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HDGFRP3 Gene

HapMap Linkage Disequilibrium report
HDGFRP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDGFRP3 Gene

Disorders for HDGFRP3 Gene

No disorders were found for HDGFRP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for HDGFRP3 Gene

Publications for HDGFRP3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J. … Elledge S.J. (Nat. Biotechnol. 2013) 3
  4. Depletion of hepatoma-derived growth factor-related protein-3 induces apoptotic sensitization of radioresistant A549 cells via reactive oxygen species-dependent p53 activation. (PMID: 24012673) Yun H.S. … Hwang S.G. (Biochem. Biophys. Res. Commun. 2013) 3
  5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3

Products for HDGFRP3 Gene

Sources for HDGFRP3 Gene

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