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Aliases for HDGFRP3 Gene

Aliases for HDGFRP3 Gene

  • Hepatoma-Derived Growth Factor, Related Protein 3 3
  • Hepatoma-Derived Growth Factor-Related Protein 3 3 5
  • Hepatoma-Derived Growth Factor 2 3 4
  • HDGF-2 3 4
  • HDGF2 3 4
  • HRP-3 3 4
  • RP11-382A20.3 5
  • CGI-142 3

External Ids for HDGFRP3 Gene

Previous GeneCards Identifiers for HDGFRP3 Gene

  • GC15M079733
  • GC15M076838
  • GC15M081385
  • GC15M081526
  • GC15M081597
  • GC15M083806
  • GC15M060070
  • GC15M083784

Summaries for HDGFRP3 Gene

GeneCards Summary for HDGFRP3 Gene

HDGFRP3 (Hepatoma-Derived Growth Factor, Related Protein 3) is a Protein Coding gene. GO annotations related to this gene include growth factor activity. An important paralog of this gene is PSIP1.

UniProtKB/Swiss-Prot for HDGFRP3 Gene

  • Enhances DNA synthesis and may play a role in cell proliferation.

Gene Wiki entry for HDGFRP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDGFRP3 Gene

Genomics for HDGFRP3 Gene

Regulatory Elements for HDGFRP3 Gene

Enhancers for HDGFRP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F082260 0.6 ENCODE 14.2 +945.7 945665 3.1 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF207 FOS KLF13 SP3 SAXO2 CSPG4P10 HDGFRP3 CPEB1 AP3B2 EFL1 GC15M082251
GH15F082803 1.4 FANTOM5 Ensembl ENCODE 11 +399.4 399407 9.8 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 WHAMM AP3B2 FAM103A1 CPEB1-AS1 CPEB1 SCARNA15 EFL1 HDGFRP3 GOLGA6L9 C15orf40
GH15F083277 1.1 FANTOM5 Ensembl ENCODE 8.2 -75.8 -75751 12.4 HDGF PKNOX1 CBX5 SCRT2 RCOR1 FOS CREM EGR2 CBFB CEBPB BNC1 BTBD1 HDGFRP3 GOLGA6L9 AP3B2 FAM103A1 HOMER2 UBE2Q2P2 LOC105370932
GH15F082763 0.6 ENCODE 6.4 +444.2 444181 1.3 SOX13 ELF3 DRAP1 PKNOX1 SAP130 MLX ARID4B DMAP1 RAD21 ZNF644 WHAMM HDGFRP3 ENSG00000277864 FSD2
GH15F082743 0.4 FANTOM5 6 +464.6 464588 0.1 AP3B2 FSD2 HDGFRP3 ACTG1P17 ENSG00000259442
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HDGFRP3 on UCSC Golden Path with GeneCards custom track

Promoters for HDGFRP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001454508 918 3401 SIN3A GLI4 ZNF2 GTF3C2 GLIS2 GATA2 KLF7 KLF13 SP3 YY2

Genomic Location for HDGFRP3 Gene

Chromosome:
15
Start:
83,112,738 bp from pter
End:
83,208,018 bp from pter
Size:
95,281 bases
Orientation:
Minus strand

Genomic View for HDGFRP3 Gene

Genes around HDGFRP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDGFRP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDGFRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDGFRP3 Gene

Proteins for HDGFRP3 Gene

  • Protein details for HDGFRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3E1-HDGR3_HUMAN
    Recommended name:
    Hepatoma-derived growth factor-related protein 3
    Protein Accession:
    Q9Y3E1

    Protein attributes for HDGFRP3 Gene

    Size:
    203 amino acids
    Molecular mass:
    22620 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HDGFRP3 Gene

Post-translational modifications for HDGFRP3 Gene

  • Ubiquitination at Lys 66
  • Modification sites at PhosphoSitePlus

Other Protein References for HDGFRP3 Gene

No data available for DME Specific Peptides for HDGFRP3 Gene

Domains & Families for HDGFRP3 Gene

Protein Domains for HDGFRP3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HDGFRP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3E1

UniProtKB/Swiss-Prot:

HDGR3_HUMAN :
  • Contains 1 PWWP domain.
  • Belongs to the HDGF family.
Domain:
  • Contains 1 PWWP domain.
Family:
  • Belongs to the HDGF family.
genes like me logo Genes that share domains with HDGFRP3: view

No data available for Gene Families for HDGFRP3 Gene

Function for HDGFRP3 Gene

Molecular function for HDGFRP3 Gene

UniProtKB/Swiss-Prot Function:
Enhances DNA synthesis and may play a role in cell proliferation.

Gene Ontology (GO) - Molecular Function for HDGFRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding ISS --
GO:0008083 growth factor activity IEA --
GO:0015631 tubulin binding ISS --
genes like me logo Genes that share ontologies with HDGFRP3: view

Phenotypes for HDGFRP3 Gene

genes like me logo Genes that share phenotypes with HDGFRP3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HDGFRP3 Gene

Localization for HDGFRP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDGFRP3 Gene

Gene Ontology (GO) - Cellular Components for HDGFRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10581169
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with HDGFRP3: view

No data available for Subcellular locations from COMPARTMENTS for HDGFRP3 Gene

Pathways & Interactions for HDGFRP3 Gene

SuperPathways for HDGFRP3 Gene

No Data Available

Interacting Proteins for HDGFRP3 Gene

Gene Ontology (GO) - Biological Process for HDGFRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007026 negative regulation of microtubule depolymerization ISS --
GO:0008283 cell proliferation NAS 10581169
GO:0031175 neuron projection development ISS --
GO:0046785 microtubule polymerization ISS --
genes like me logo Genes that share ontologies with HDGFRP3: view

No data available for Pathways by source and SIGNOR curated interactions for HDGFRP3 Gene

Transcripts for HDGFRP3 Gene

Unigene Clusters for HDGFRP3 Gene

Hepatoma-derived growth factor, related protein 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDGFRP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2:
SP3:

Relevant External Links for HDGFRP3 Gene

GeneLoc Exon Structure for
HDGFRP3

Expression for HDGFRP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HDGFRP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HDGFRP3 Gene

This gene is overexpressed in Retina (11.9) and Fetal Brain (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HDGFRP3 Gene



Protein tissue co-expression partners for HDGFRP3 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for HDGFRP3 Gene:

Hs.513954

mRNA Expression by UniProt/SwissProt for HDGFRP3 Gene:

Q9Y3E1-HDGR3_HUMAN
Tissue specificity: Detected in testis, heart, spinal cord and brain.
genes like me logo Genes that share expression patterns with HDGFRP3: view

Primer Products

No data available for mRNA differential expression in normal tissues for HDGFRP3 Gene

Orthologs for HDGFRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HDGFRP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDGFRP3 34
  • 100 (n)
-- 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 99 (a)
OneToOne
HDGFRP3 34
  • 94.54 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hdgfrp3 34 16 35
  • 94.39 (n)
rat
(Rattus norvegicus)
Mammalia Hdgfrp3 34
  • 94.22 (n)
cow
(Bos Taurus)
Mammalia HDGFRP3 34 35
  • 93.92 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves HDGFRP3 34
  • 87.5 (n)
-- 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdgfrp3 34
  • 81.02 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01088864.1 35
  • 100 (a)
OneToOne
hdgfrp3 34
  • 68.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7946 35
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06A5.3 35
  • 6 (a)
OneToMany
Species where no ortholog for HDGFRP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDGFRP3 Gene

ENSEMBL:
Gene Tree for HDGFRP3 (if available)
TreeFam:
Gene Tree for HDGFRP3 (if available)

Paralogs for HDGFRP3 Gene

Paralogs for HDGFRP3 Gene

(4) SIMAP similar genes for HDGFRP3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for HDGFRP3 Gene

genes like me logo Genes that share paralogs with HDGFRP3: view

Variants for HDGFRP3 Gene

Sequence variations from dbSNP and Humsavar for HDGFRP3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10520576 -- 83,149,520(+) AACCT(A/G)GAGGA intron-variant
rs1075619 -- 83,112,722(+) ATGCA(C/T)TCAAT intron-variant, downstream-variant-500B
rs1112404 -- 83,173,728(+) CTCAA(A/C)TTTTC intron-variant
rs111280017 -- 83,209,024(+) CCCCC(-/T)CTCTG upstream-variant-2KB
rs111313714 -- 83,145,871(+) TTTTT(C/T)TTCTC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HDGFRP3 Gene

Variant ID Type Subtype PubMed ID
esv2478815 CNV deletion 19546169
esv3420115 CNV insertion 20981092
esv3569787 CNV gain 25503493
nsv1113726 CNV deletion 24896259
nsv1120052 OTHER inversion 24896259
nsv479714 CNV novel sequence insertion 20440878
nsv94888 CNV insertion 16902084
nsv984103 CNV duplication 23825009

Variation tolerance for HDGFRP3 Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HDGFRP3 Gene

Disorders for HDGFRP3 Gene

Relevant External Links for HDGFRP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HDGFRP3

No disorders were found for HDGFRP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDGFRP3 Gene

Publications for HDGFRP3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4 64
  4. A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus. (PMID: 10581169) Ikegame K. … Nakamura H. (Biochem. Biophys. Res. Commun. 1999) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for HDGFRP3 Gene

Sources for HDGFRP3 Gene

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