Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HDGFRP2 Gene

Aliases for HDGFRP2 Gene

  • Hepatoma-Derived Growth Factor-Related Protein 2 3
  • HDGF-2 3 4
  • HDGF2 3 4
  • HRP-2 3 4
  • Hepatoma-Derived Growth Factor 2 4

External Ids for HDGFRP2 Gene

Previous GeneCards Identifiers for HDGFRP2 Gene

  • GC19P004234

Summaries for HDGFRP2 Gene

Entrez Gene Summary for HDGFRP2 Gene

  • This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for HDGFRP2 Gene

HDGFRP2 (Hepatoma-Derived Growth Factor-Related Protein 2) is a Protein Coding gene. An important paralog of this gene is HDGFL1.

UniProtKB/Swiss-Prot for HDGFRP2 Gene

  • Involved in cellular growth control, through the regulation of cyclin D1 expression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDGFRP2 Gene

Genomics for HDGFRP2 Gene

Genomic Location for HDGFRP2 Gene

4,472,258 bp from pter
4,502,211 bp from pter
29,954 bases
Plus strand

Genomic View for HDGFRP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HDGFRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDGFRP2 Gene

No data available for Regulatory Elements for HDGFRP2 Gene

Proteins for HDGFRP2 Gene

  • Protein details for HDGFRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatoma-derived growth factor-related protein 2
    Protein Accession:
    Secondary Accessions:
    • I3L080
    • K7EQZ6
    • Q96GI5
    • Q9BW08

    Protein attributes for HDGFRP2 Gene

    671 amino acids
    Molecular mass:
    74317 Da
    Quaternary structure:
    • Interacts with HDGF (By similarity). Interacts with trimethylated Lys-36 of histone H3 (H3K36me3). Interacts with trimethylated Lys-79 of histone H3 (H3K79me3), but has higher affinity for H3K36me3. Interacts with IWS1 (PubMed:25689719).

    Three dimensional structures from OCA and Proteopedia for HDGFRP2 Gene

    Alternative splice isoforms for HDGFRP2 Gene


neXtProt entry for HDGFRP2 Gene

Proteomics data for HDGFRP2 Gene at MOPED

Post-translational modifications for HDGFRP2 Gene

  • Ubiquitination at Lys487 and Lys494
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HDGFRP2 Gene

Domains for HDGFRP2 Gene

Protein Domains for HDGFRP2 Gene


Suggested Antigen Peptide Sequences for HDGFRP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q7Z4V5
  • Contains 1 PWWP domain.
  • Belongs to the HDGF family.
genes like me logo Genes that share domains with HDGFRP2: view

No data available for Gene Families for HDGFRP2 Gene

Function for HDGFRP2 Gene

Molecular function for HDGFRP2 Gene

UniProtKB/Swiss-Prot Function: Involved in cellular growth control, through the regulation of cyclin D1 expression.

Gene Ontology (GO) - Molecular Function for HDGFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 25689719
genes like me logo Genes that share ontologies with HDGFRP2: view

Phenotypes for HDGFRP2 Gene

genes like me logo Genes that share phenotypes with HDGFRP2: view

Animal Models for HDGFRP2 Gene

MGI Knock Outs for HDGFRP2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HDGFRP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HDGFRP2 Gene

Localization for HDGFRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDGFRP2 Gene

Subcellular locations from

Jensen Localization Image for HDGFRP2 Gene COMPARTMENTS Subcellular localization image for HDGFRP2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for HDGFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with HDGFRP2: view

Pathways for HDGFRP2 Gene

SuperPathways for HDGFRP2 Gene

No Data Available

Interacting Proteins for HDGFRP2 Gene

Selected Interacting proteins: Q7Z4V5-HDGR2_HUMAN for HDGFRP2 Gene via I2D

Gene Ontology (GO) - Biological Process for HDGFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0030307 positive regulation of cell growth IMP 25689719
genes like me logo Genes that share ontologies with HDGFRP2: view

No data available for Pathways by source for HDGFRP2 Gene

Transcripts for HDGFRP2 Gene

Unigene Clusters for HDGFRP2 Gene

Hepatoma-derived growth factor-related protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HDGFRP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDGFRP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d
SP2: - - -
SP3: -
SP5: -
SP6: -

Relevant External Links for HDGFRP2 Gene

GeneLoc Exon Structure for

Expression for HDGFRP2 Gene

mRNA expression in normal human tissues for HDGFRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HDGFRP2 Gene

SOURCE GeneReport for Unigene cluster for HDGFRP2 Gene Hs.43071

mRNA Expression by UniProt/SwissProt for HDGFRP2 Gene

Tissue specificity: Widely expressed. High expression is found in heart, skeletal muscle, ovary and testis. Overexpression is frequently observed in hepatocellular carcinoma samples.
genes like me logo Genes that share expressions with HDGFRP2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HDGFRP2 Gene

Orthologs for HDGFRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HDGFRP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
LOC738335 35
  • 98.73 (n)
  • 98.1 (a)
(Bos Taurus)
Mammalia -- 36
  • 84 (a)
  • 81.8 (n)
  • 83.68 (a)
(Canis familiaris)
Mammalia -- 36
  • 85 (a)
  • 82.13 (n)
  • 85.76 (a)
(Mus musculus)
Mammalia Hdgfrp2 35
  • 79.75 (n)
  • 83.03 (a)
Hdgfrp2 16
Hdgfrp2 36
  • 81 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
(Rattus norvegicus)
Mammalia Hdgfrp2 35
  • 79.67 (n)
  • 81.64 (a)
(Gallus gallus)
Aves -- 36
  • 70 (a)
LOC772302 35
  • 69.62 (n)
  • 70.57 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75972 35
(Danio rerio)
Actinopterygii hdgfrp2 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7946 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea C06A5.3 36
  • 16 (a)
Species with no ortholog for HDGFRP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDGFRP2 Gene

Gene Tree for HDGFRP2 (if available)
Gene Tree for HDGFRP2 (if available)

Paralogs for HDGFRP2 Gene

Paralogs for HDGFRP2 Gene

genes like me logo Genes that share paralogs with HDGFRP2: view

Variants for HDGFRP2 Gene

Sequence variations from dbSNP and Humsavar for HDGFRP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs892159 -- 4,500,812(-) CTGAG(C/T)AACAT intron-variant
rs892160 -- 4,499,927(-) AAGTT(A/G)CCTGC intron-variant
rs892161 -- 4,493,711(-) GCTGA(C/T)GGCGC reference, synonymous-codon
rs919797 -- 4,498,160(-) ACCGC(C/T)GGCCA intron-variant
rs919798 -- 4,498,157(-) GCCGG(C/T)CAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDGFRP2 Gene

Variant ID Type Subtype PubMed ID
nsv910817 CNV Loss 21882294
nsv833718 CNV Loss 17160897
nsv910820 CNV Gain 21882294
dgv3674n71 CNV Loss 21882294
nsv833720 CNV Loss 17160897
dgv3676n71 CNV Loss 21882294
dgv3677n71 CNV Loss 21882294
nsv910836 CNV Loss 21882294
nsv910837 CNV Loss 21882294
nsv470116 CNV Loss 18288195
nsv910839 CNV Loss 21882294
dgv3678n71 CNV Loss 21882294
nsv910842 CNV Loss 21882294
nsv910843 CNV Loss 21882294

Relevant External Links for HDGFRP2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDGFRP2 Gene

Disorders for HDGFRP2 Gene

No disorders were found for HDGFRP2 Gene.

No data available for UniProtKB/Swiss-Prot for HDGFRP2 Gene

Publications for HDGFRP2 Gene

  1. Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. (PMID: 16337983) Vandegraaff N. … Engelman A. (Virology 2006) 3 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Structural and histone binding ability characterizations of human PWWP domains. (PMID: 21720545) Wu H. … Min J. (PLoS ONE 2011) 3 4
  4. HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma. (PMID: 25689719) Gao K. … Zhang P. (Biochem. Biophys. Res. Commun. 2015) 3 4
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for HDGFRP2 Gene

Sources for HDGFRP2 Gene

Back to Top