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Aliases for HDGFRP2 Gene

Aliases for HDGFRP2 Gene

  • Hepatoma-Derived Growth Factor-Related Protein 2 3 5
  • HDGF-2 3 4
  • HDGF2 3 4
  • HRP-2 3 4
  • Hepatoma-Derived Growth Factor 2 4
  • CTB-50L17.10 5

External Ids for HDGFRP2 Gene

Previous GeneCards Identifiers for HDGFRP2 Gene

  • GC19P004234

Summaries for HDGFRP2 Gene

Entrez Gene Summary for HDGFRP2 Gene

  • This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for HDGFRP2 Gene

HDGFRP2 (Hepatoma-Derived Growth Factor-Related Protein 2) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is PSIP1.

UniProtKB/Swiss-Prot for HDGFRP2 Gene

  • Involved in cellular growth control, through the regulation of cyclin D1 expression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDGFRP2 Gene

Genomics for HDGFRP2 Gene

Regulatory Elements for HDGFRP2 Gene

Enhancers for HDGFRP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F004470 0.7 ENCODE 8.5 +0.6 630 5.0 HDGF PKNOX1 ARNT SIN3A ARID4B DMAP1 YY1 ZNF143 FOS KLF13 HDGFRP2 ENSG00000267769 GC19P004486
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HDGFRP2 on UCSC Golden Path with GeneCards custom track

Promoters for HDGFRP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001014772 804 4401 HDGF PKNOX1 ARNT SIN3A ARID4B DMAP1 YY1 ZNF143 FOS KLF13

Genomic Location for HDGFRP2 Gene

Chromosome:
19
Start:
4,472,196 bp from pter
End:
4,502,220 bp from pter
Size:
30,025 bases
Orientation:
Plus strand

Genomic View for HDGFRP2 Gene

Genes around HDGFRP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDGFRP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDGFRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDGFRP2 Gene

Proteins for HDGFRP2 Gene

  • Protein details for HDGFRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4V5-HDGR2_HUMAN
    Recommended name:
    Hepatoma-derived growth factor-related protein 2
    Protein Accession:
    Q7Z4V5
    Secondary Accessions:
    • I3L080
    • K7EQZ6
    • Q96GI5
    • Q9BW08

    Protein attributes for HDGFRP2 Gene

    Size:
    671 amino acids
    Molecular mass:
    74317 Da
    Quaternary structure:
    • Interacts with HDGF (By similarity). Interacts with trimethylated Lys-36 of histone H3 (H3K36me3). Interacts with trimethylated Lys-79 of histone H3 (H3K79me3), but has higher affinity for H3K36me3. Interacts with IWS1 (PubMed:25689719).

    Three dimensional structures from OCA and Proteopedia for HDGFRP2 Gene

    Alternative splice isoforms for HDGFRP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDGFRP2 Gene

Post-translational modifications for HDGFRP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HDGFRP2 Gene

Domains & Families for HDGFRP2 Gene

Protein Domains for HDGFRP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HDGFRP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z4V5

UniProtKB/Swiss-Prot:

HDGR2_HUMAN :
  • Contains 1 PWWP domain.
  • Belongs to the HDGF family.
Domain:
  • Contains 1 PWWP domain.
Family:
  • Belongs to the HDGF family.
genes like me logo Genes that share domains with HDGFRP2: view

No data available for Gene Families for HDGFRP2 Gene

Function for HDGFRP2 Gene

Molecular function for HDGFRP2 Gene

UniProtKB/Swiss-Prot Function:
Involved in cellular growth control, through the regulation of cyclin D1 expression.

Gene Ontology (GO) - Molecular Function for HDGFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with HDGFRP2: view

Phenotypes for HDGFRP2 Gene

genes like me logo Genes that share phenotypes with HDGFRP2: view

Animal Models for HDGFRP2 Gene

MGI Knock Outs for HDGFRP2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HDGFRP2 Gene

Localization for HDGFRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDGFRP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HDGFRP2 Gene COMPARTMENTS Subcellular localization image for HDGFRP2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for HDGFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HDGFRP2: view

Pathways & Interactions for HDGFRP2 Gene

SuperPathways for HDGFRP2 Gene

No Data Available

Interacting Proteins for HDGFRP2 Gene

Gene Ontology (GO) - Biological Process for HDGFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0030307 positive regulation of cell growth IMP 25689719
genes like me logo Genes that share ontologies with HDGFRP2: view

No data available for Pathways by source and SIGNOR curated interactions for HDGFRP2 Gene

Transcripts for HDGFRP2 Gene

Unigene Clusters for HDGFRP2 Gene

Hepatoma-derived growth factor-related protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDGFRP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d
SP1:
SP2: - - -
SP3: -
SP4:
SP5: -
SP6: -

Relevant External Links for HDGFRP2 Gene

GeneLoc Exon Structure for
HDGFRP2

Expression for HDGFRP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HDGFRP2 Gene

Protein differential expression in normal tissues from HIPED for HDGFRP2 Gene

This gene is overexpressed in Adrenal (29.2) and Nasal epithelium (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HDGFRP2 Gene



Protein tissue co-expression partners for HDGFRP2 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for HDGFRP2 Gene:

Hs.43071

mRNA Expression by UniProt/SwissProt for HDGFRP2 Gene:

Q7Z4V5-HDGR2_HUMAN
Tissue specificity: Widely expressed. High expression is found in heart, skeletal muscle, ovary and testis. Overexpression is frequently observed in hepatocellular carcinoma samples.
genes like me logo Genes that share expression patterns with HDGFRP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HDGFRP2 Gene

Orthologs for HDGFRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HDGFRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC738335 34
  • 98.73 (n)
-- 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 85 (a)
OneToOne
HDGFRP2 34
  • 82.13 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 84 (a)
OneToOne
HDGFRP2 34
  • 81.8 (n)
mouse
(Mus musculus)
Mammalia Hdgfrp2 34 16 35
  • 79.75 (n)
rat
(Rattus norvegicus)
Mammalia Hdgfrp2 34
  • 79.67 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 70 (a)
OneToOne
LOC772302 34
  • 69.62 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75972 34
zebrafish
(Danio rerio)
Actinopterygii hdgfrp2 35
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7946 35
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06A5.3 35
  • 16 (a)
OneToMany
Species where no ortholog for HDGFRP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDGFRP2 Gene

ENSEMBL:
Gene Tree for HDGFRP2 (if available)
TreeFam:
Gene Tree for HDGFRP2 (if available)

Paralogs for HDGFRP2 Gene

Variants for HDGFRP2 Gene

Sequence variations from dbSNP and Humsavar for HDGFRP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401202 -- 4,489,134(+) ttttt(G/T)ttaga intron-variant
rs10405224 -- 4,482,666(+) TGGCT(A/G)TGACC intron-variant
rs10406139 -- 4,498,703(+) CAGAT(A/T)CAGCT intron-variant
rs10406517 -- 4,470,388(+) cctga(C/T)cttaa upstream-variant-2KB
rs10406524 -- 4,486,047(+) gaccc(C/T)gtctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDGFRP2 Gene

Variant ID Type Subtype PubMed ID
dgv1979e59 CNV duplication 20981092
nsv1116293 CNV deletion 24896259
nsv470116 CNV loss 18288195
nsv578444 CNV gain 21841781
nsv833718 CNV loss 17160897
nsv833720 CNV loss 17160897

Variation tolerance for HDGFRP2 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HDGFRP2 Gene

Human Gene Mutation Database (HGMD)
HDGFRP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDGFRP2 Gene

Disorders for HDGFRP2 Gene

Relevant External Links for HDGFRP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HDGFRP2

No disorders were found for HDGFRP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDGFRP2 Gene

Publications for HDGFRP2 Gene

  1. HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma. (PMID: 25689719) Gao K. … Zhang P. (Biochem. Biophys. Res. Commun. 2015) 3 4 64
  2. Structural and histone binding ability characterizations of human PWWP domains. (PMID: 21720545) Wu H. … Min J. (PLoS ONE 2011) 3 4 64
  3. Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. (PMID: 16337983) Vandegraaff N. … Engelman A. (Virology 2006) 3 22 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination. (PMID: 26721387) Baude A. … JAoAottelAo M. (Nucleic Acids Res. 2016) 3 64

Products for HDGFRP2 Gene

Sources for HDGFRP2 Gene

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