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Aliases for HDGFRP2 Gene

Aliases for HDGFRP2 Gene

  • Hepatoma-Derived Growth Factor-Related Protein 2 3 5
  • HDGF-2 3 4
  • HDGF2 3 4
  • HRP-2 3 4
  • Hepatoma-Derived Growth Factor 2 4
  • CTB-50L17.10 5

External Ids for HDGFRP2 Gene

Previous GeneCards Identifiers for HDGFRP2 Gene

  • GC19P004234

Summaries for HDGFRP2 Gene

Entrez Gene Summary for HDGFRP2 Gene

  • This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for HDGFRP2 Gene

HDGFRP2 (Hepatoma-Derived Growth Factor-Related Protein 2) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is PSIP1.

UniProtKB/Swiss-Prot for HDGFRP2 Gene

  • Involved in cellular growth control, through the regulation of cyclin D1 expression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDGFRP2 Gene

Genomics for HDGFRP2 Gene

Regulatory Elements for HDGFRP2 Gene

Enhancers for HDGFRP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HDGFRP2 on UCSC Golden Path with GeneCards custom track

Promoters for HDGFRP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HDGFRP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HDGFRP2 Gene

4,472,196 bp from pter
4,502,220 bp from pter
30,025 bases
Plus strand

Genomic View for HDGFRP2 Gene

Genes around HDGFRP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDGFRP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDGFRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDGFRP2 Gene

Proteins for HDGFRP2 Gene

  • Protein details for HDGFRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatoma-derived growth factor-related protein 2
    Protein Accession:
    Secondary Accessions:
    • I3L080
    • K7EQZ6
    • Q96GI5
    • Q9BW08

    Protein attributes for HDGFRP2 Gene

    671 amino acids
    Molecular mass:
    74317 Da
    Quaternary structure:
    • Interacts with HDGF (By similarity). Interacts with trimethylated Lys-36 of histone H3 (H3K36me3). Interacts with trimethylated Lys-79 of histone H3 (H3K79me3), but has higher affinity for H3K36me3. Interacts with IWS1 (PubMed:25689719).

    Three dimensional structures from OCA and Proteopedia for HDGFRP2 Gene

    Alternative splice isoforms for HDGFRP2 Gene


neXtProt entry for HDGFRP2 Gene

Proteomics data for HDGFRP2 Gene at MOPED

Post-translational modifications for HDGFRP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for HRP2
  • Santa Cruz Biotechnology (SCBT) Antibodies for HDGFRP2

No data available for DME Specific Peptides for HDGFRP2 Gene

Domains & Families for HDGFRP2 Gene

Protein Domains for HDGFRP2 Gene


Suggested Antigen Peptide Sequences for HDGFRP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PWWP domain.
  • Belongs to the HDGF family.
  • Contains 1 PWWP domain.
  • Belongs to the HDGF family.
genes like me logo Genes that share domains with HDGFRP2: view

No data available for Gene Families for HDGFRP2 Gene

Function for HDGFRP2 Gene

Molecular function for HDGFRP2 Gene

UniProtKB/Swiss-Prot Function:
Involved in cellular growth control, through the regulation of cyclin D1 expression.

Gene Ontology (GO) - Molecular Function for HDGFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 21044950
genes like me logo Genes that share ontologies with HDGFRP2: view

Phenotypes for HDGFRP2 Gene

genes like me logo Genes that share phenotypes with HDGFRP2: view

Animal Models for HDGFRP2 Gene

MGI Knock Outs for HDGFRP2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HDGFRP2 Gene

Localization for HDGFRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDGFRP2 Gene

Subcellular locations from

Jensen Localization Image for HDGFRP2 Gene COMPARTMENTS Subcellular localization image for HDGFRP2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for HDGFRP2 Gene

Pathways & Interactions for HDGFRP2 Gene

SuperPathways for HDGFRP2 Gene

No Data Available

Interacting Proteins for HDGFRP2 Gene

Gene Ontology (GO) - Biological Process for HDGFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030307 positive regulation of cell growth IMP 25689719
genes like me logo Genes that share ontologies with HDGFRP2: view

No data available for Pathways by source and SIGNOR curated interactions for HDGFRP2 Gene

Drugs & Compounds for HDGFRP2 Gene

No Compound Related Data Available

Transcripts for HDGFRP2 Gene

Unigene Clusters for HDGFRP2 Gene

Hepatoma-derived growth factor-related protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HDGFRP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d
SP2: - - -
SP3: -
SP5: -
SP6: -

Relevant External Links for HDGFRP2 Gene

GeneLoc Exon Structure for

Expression for HDGFRP2 Gene

mRNA expression in normal human tissues for HDGFRP2 Gene

Protein differential expression in normal tissues from HIPED for HDGFRP2 Gene

This gene is overexpressed in Adrenal (29.2) and Nasal epithelium (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for HDGFRP2 Gene

SOURCE GeneReport for Unigene cluster for HDGFRP2 Gene Hs.43071

mRNA Expression by UniProt/SwissProt for HDGFRP2 Gene

Tissue specificity: Widely expressed. High expression is found in heart, skeletal muscle, ovary and testis. Overexpression is frequently observed in hepatocellular carcinoma samples.
genes like me logo Genes that share expression patterns with HDGFRP2: view

Protein tissue co-expression partners for HDGFRP2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HDGFRP2 Gene

Orthologs for HDGFRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HDGFRP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HDGFRP2 35
  • 81.8 (n)
  • 83.68 (a)
-- 36
  • 84 (a)
(Canis familiaris)
Mammalia HDGFRP2 35
  • 82.13 (n)
  • 85.76 (a)
-- 36
  • 85 (a)
(Mus musculus)
Mammalia Hdgfrp2 35
  • 79.75 (n)
  • 83.03 (a)
Hdgfrp2 16
Hdgfrp2 36
  • 81 (a)
(Pan troglodytes)
Mammalia LOC738335 35
  • 98.73 (n)
  • 98.1 (a)
-- 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Hdgfrp2 35
  • 79.67 (n)
  • 81.64 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
(Gallus gallus)
Aves LOC772302 35
  • 69.62 (n)
  • 70.57 (a)
-- 36
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75972 35
(Danio rerio)
Actinopterygii hdgfrp2 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7946 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea C06A5.3 36
  • 16 (a)
Species with no ortholog for HDGFRP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDGFRP2 Gene

Gene Tree for HDGFRP2 (if available)
Gene Tree for HDGFRP2 (if available)

Paralogs for HDGFRP2 Gene

Paralogs for HDGFRP2 Gene

genes like me logo Genes that share paralogs with HDGFRP2: view

Variants for HDGFRP2 Gene

Sequence variations from dbSNP and Humsavar for HDGFRP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256481 -- 4,481,286(+) ccttg(A/G)ttcat intron-variant
rs7260311 -- 4,489,111(+) accgc(A/G)cttgg intron-variant
rs7260358 -- 4,473,805(+) GTCCC(C/T)TGTGG intron-variant, upstream-variant-2KB
rs7260476 -- 4,489,280(+) gatgg(A/G)gttcc intron-variant
rs12975873 -- 4,490,877(+) cgcaa(C/T)ctcgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDGFRP2 Gene

Variant ID Type Subtype PubMed ID
nsv910817 CNV Loss 21882294
nsv833718 CNV Loss 17160897
nsv910820 CNV Gain 21882294
dgv3674n71 CNV Loss 21882294
nsv833720 CNV Loss 17160897
dgv3676n71 CNV Loss 21882294
dgv3677n71 CNV Loss 21882294
nsv910836 CNV Loss 21882294
nsv910837 CNV Loss 21882294
nsv470116 CNV Loss 18288195
nsv910839 CNV Loss 21882294
dgv3678n71 CNV Loss 21882294
nsv910842 CNV Loss 21882294
nsv910843 CNV Loss 21882294

Variation tolerance for HDGFRP2 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HDGFRP2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDGFRP2 Gene

Disorders for HDGFRP2 Gene

No disorders were found for HDGFRP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for HDGFRP2 Gene

Publications for HDGFRP2 Gene

  1. HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma. (PMID: 25689719) Gao K. … Zhang P. (Biochem. Biophys. Res. Commun. 2015) 3 4 67
  2. Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. (PMID: 16337983) Vandegraaff N. … Engelman A. (Virology 2006) 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for HDGFRP2 Gene

Sources for HDGFRP2 Gene