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HDGFRP2 Gene

protein-coding   GIFtS: 45
GCID: GC19P004472

Hepatoma-Derived Growth Factor-Related Protein 2


  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hepatoma-Derived Growth Factor 22 3
HDGF-22 3
HDGF22 3
HRP-22 3
Hepatoma-Derived Growth Factor-Related Protein 22

External Ids:    Entrez Gene: 847172   Ensembl: ENSG000001676747   UniProtKB: Q7Z4V53   

Export aliases for HDGFRP2 gene to outside databases

Previous GC identifer: GC19P004234


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HDGFRP2 Gene:
This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. Two alternatively spliced
transcript variants encoding slightly different isoforms have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for HDGFRP2 Gene:
HDGFRP2 is a protein-coding gene. Diseases associated with HDGFRP2 include tonsillitis, and hiv-1. An important paralog of this gene is HDGF.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Search for regulatory transcription factor binding sites for HDGFRP2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHDGFRP2 promoter sequence
   Search Chromatin IP Primers for HDGFRP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HDGFRP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   

HDGFRP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDGFRP2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P004472:  view genomic region     (about GC identifiers)

Start:
4,472,255 bp from pter      End:
4,502,223 bp from pter
Size:
29,969 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HDGR2_HUMAN, Q7Z4V5 (See protein sequence)
Recommended Name: Hepatoma-derived growth factor-related protein 2  
Size: 671 amino acids; 74317 Da
Subunit: Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of
histone H3 (H3K79me3), but has higher affinity for H3K36me3
3 PDB 3D structures from and Proteopedia for HDGFRP2:
3EAE (3D)        3QBY (3D)        3QJ6 (3D)    
Secondary accessions: I3L080 Q96GI5 Q9BW08
Alternative splicing: 3 isoforms:  Q7Z4V5-1   Q7Z4V5-2   Q7Z4V5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HDGFRP2: NX_Q7Z4V5

Explore proteomics data for HDGFRP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys487, Lys494
  • Modification sites at PhosphoSitePlus

  • See HDGFRP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001001520.1  NP_116020.1  

    ENSEMBL proteins: 
     ENSP00000301284   ENSP00000468044   ENSP00000471276   ENSP00000465267   ENSP00000467617  
     ENSP00000467966   ENSP00000468175   ENSP00000467513   ENSP00000468340   ENSP00000465276  
     ENSP00000464738  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR017923 TFIIS_N
     IPR000313 PWWP_dom
     IPR021567 LEDGF

    Graphical View of Domain Structure for InterPro Entry Q7Z4V5

    ProtoNet protein and cluster: Q7Z4V5

    1 Blocks protein domain: IPB000313 PWWP domain

    UniProtKB/Swiss-Prot: HDGR2_HUMAN, Q7Z4V5
    Similarity: Belongs to the HDGF family
    Similarity: Contains 1 PWWP domain


    HDGFRP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding ----
         
    HDGFRP2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hdgfrp2):
     cellular  homeostasis/metabolism 

    HDGFRP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hdgfrp2tm1Lex for HDGFRP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HDGFRP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HDGFRP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HDGFRP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HDGFRP2

    miRNA
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    Block miRNA regulation of human, mouse, rat HDGFRP2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HDGFRP2:
    hsa-miR-548d-3p
    SwitchGear 3'UTR luciferase reporter plasmidHDGFRP2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat HDGFRP2

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    GenScript: all cDNA clones in your preferred vector (see all 2): HDGFRP2 (NM_032631)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDGFRP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HDGFRP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HDGFRP2
    Interactions:

        Search GeneGlobe Interaction Network for HDGFRP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for HDGFRP2 (Q7Z4V53 ENSP000003012844) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB1P494073, ENSP000003771414I2D: score=2 STRING: ENSP00000377141
    SIAH1Q8IUQ43I2D: score=5 
    RAD54LQ926983I2D: score=4 
    PIH1D1Q9NWS03I2D: score=3 
    ARRB2P321213I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--

    HDGFRP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HDGFRP2 (HDGR2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HDGFRP2 gene (2 alternative transcripts): 
    NM_001001520.1  NM_032631.2  

    Unigene Cluster for HDGFRP2:

    Hepatoma-derived growth factor-related protein 2
    Hs.43071  [show with all ESTs]
    Unigene Representative Sequence: AB208892
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301284(uc002map.3 uc002mao.3 uc010dtz.1 uc002maq.1 uc010dua.3)
    ENST00000586684 ENST00000601353 ENST00000589486 ENST00000592691 ENST00000590872
    ENST00000587016 ENST00000592417 ENST00000586428 ENST00000591328 ENST00000588271

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HDGFRP2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HDGFRP2:
    hsa-miR-548d-3p
    SwitchGear 3'UTR luciferase reporter plasmidHDGFRP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HDGFRP2
    Predesigned siRNA for gene silencing in human, mouse, rat HDGFRP2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HDGFRP2 (NM_032631)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDGFRP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDGFRP2
    Primer
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    OriGene qPCR primer pairs and template standards for HDGFRP2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HDGFRP2
      QuantiTect SYBR Green Assays in human, mouse, rat HDGFRP2
      QuantiFast Probe-based Assays in human, mouse, rat HDGFRP2

    Additional mRNA sequence: 

    AB208892.1 AF294267.1 AK027353.1 AY358600.1 BC000755.2 BC009449.1 BC126984.1 BC126985.1 

    10 DOTS entries:

    DT.211031  DT.95297177  DT.75103068  DT.99961788  DT.100754253  DT.121499827  DT.100026594  DT.100726578 
    DT.100777763  DT.97825722 

    Selected AceView cDNA sequences (see all 177):

    BM681995 BQ962664 AI760417 AA236672 AL134555 CR611041 CR590767 BQ064366 
    AF294267 AY358600 AL520441 BQ898864 BM729060 BC000755 AK027353 BM544712 
    NM_032631 BX384122 BE907713 BF984461 BQ685764 AI268485 BM713639 BU165411 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HDGFRP2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d
    SP1:                                                                                                                                    
    SP2:                                                                                            -     -     -                           
    SP3:        -                                                                                                                           
    SP4:                                                                                                                                    
    SP5:                                                                                                              -                     



    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HDGFRP2 expression in normal human tissues (normalized intensities)      HDGFRP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGACTAT
    HDGFRP2 Expression
    About this image


    HDGFRP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    HDGFRP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HDGFRP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.43071
        Custom PCR Arrays for HDGFRP2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDGFRP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HDGFRP2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hdgfrp21 , 5 hepatoma-derived growth factor, related protein 21, 5 79.75(n)1
    83.03(a)1
      17 (29.15 cM)5
    151931  NM_008233.21  NP_032259.11 
     560796575 
    chicken
    (Gallus gallus)
    Aves LOC7723021 hepatoma-derived growth factor-related protein 2-like 69.62(n)
    70.57(a)
      772302  XM_004948799.1  XP_004948856.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    57(a)
    1 ↔ 1
    GL343757.1(128214-151457)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480209182   -- 75.98(n)    48020918 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055551.12   -- 78.58(n)    BC055551.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79466
    --
    20(a)
    1 → many
    3R(25878236-25880419)
    worm
    (Caenorhabditis elegans)
    Secernentea C06A5.36
    Protein C06A5.3, isoform b (C06A5.3) mRNA, complet...
    16(a)
    1 → many
    I(5986492-5990581) WBGene00015501


    ENSEMBL Gene Tree for HDGFRP2 (if available)
    TreeFam Gene Tree for HDGFRP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HDGFRP2 gene
    HDGF2  PSIP12  HDGFL12  HDGFRP32  
    Selected SIMAP similar genes for HDGFRP2 using alignment to 11 protein entries:     HDGR2_HUMAN (see all proteins) (see all similar genes):
    TNNT1    ARL6IP5    CALCOCO2    SMYD4    ZNF257    ZNF799
    C1orf143    COQ5    COPS7B    EEF1E1    NDUFA7    PARK2
    RAD51    SEC14L3    ZNF564    HDGFRP3    TBC1D22A    PSIP1

    HDGFRP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HDGFRP2 (see all 790)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs766148701,2
    C--4232138(+) TCCTGC/TCTCAG 2 -- us2k10--------
    rs800928171,2
    C,F--4232165(+) GAGTAT/CAGGCG 2 -- us2k11Minor allele frequency- C:0.09NA 120
    rs1483982021,2
    --4232185(+) ACGCCC/TGGCTA 2 -- us2k10--------
    rs678435791,2
    C,F--4232186(+) CGCCCG/CGCTAA 2 -- us2k12Minor allele frequency- C:0.50NA 4
    rs104065171,2
    C,F,H--4232255(+) cctgaC/Tcttaa 2 -- us2k115Minor allele frequency- T:0.09NS EA NA WA 1890
    rs1880446631,2
    --4232364(+) GTCTGC/GTTAAA 2 -- us2k10--------
    rs1809109231,2
    --4232402(+) TCCCCC/TAGGAG 2 -- us2k10--------
    rs1509032141,2
    C--4232420(+) GTCGTC/TTCCAT 2 -- us2k10--------
    rs1845225521,2
    --4232465(+) TTTTAC/GTTCTT 2 -- us2k10--------
    rs1393782821,2
    --4232473(+) CTTACC/GATGGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for HDGFRP2 (4472255 - 4502223 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HDGFRP2 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3677n71CNV Loss21882294
    nsv910839CNV Loss21882294
    dgv3674n71CNV Loss21882294
    nsv910837CNV Loss21882294
    nsv910843CNV Loss21882294
    dgv3678n71CNV Loss21882294
    nsv470116CNV Loss18288195
    nsv910842CNV Loss21882294
    nsv910836CNV Loss21882294
    nsv833718CNV Loss17160897

    Human Gene Mutation Database (HGMD): HDGFRP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HDGFRP2
    DNA2.0 Custom Variant and Variant Library Synthesis for HDGFRP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    7 diseases for HDGFRP2:    About MalaCards
    tonsillitis    hiv-1    retinitis    thyroiditis
    cerebritis    endotheliitis    prostatitis


    HDGFRP2 for disorders           About GeneDecksing


    Export disorders for HDGFRP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HDGFRP2 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with HDGFRP2)
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    1. Structural and histone binding ability characterizations of human PWWP domains. (PubMed id 21720545)1, 2 Wu H.... Min J. (PLoS ONE 2011)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. (PubMed id 16337983)1, 9 Vandegraaff N....Engelman A. (Virology 2006)
    4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells. (PubMed id 23046603)1 Schrijvers R....Gijsbers R. (Retrovirology 2012)
    7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    8. A bead-based approach for large-scale identification of in vitro kinase substrates. (PubMed id 22113938)1 Zhang M....Zou H. (Proteomics 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84717 AceView: HDGF2 Ensembl:ENSG00000167674 euGenes: HUgn84717

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HDGFRP2 gene:
    Search GeneIP for patents involving HDGFRP2

    GeneCards and IP:
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