Aliases for HDGFL3 Gene
Aliases for HDGFL3 Gene
External Ids for HDGFL3 Gene
- HGNC: 24937
- Entrez Gene: 50810
- Ensembl: ENSG00000166503
- OMIM: 616643
- UniProtKB: Q9Y3E1
Summaries for HDGFL3 Gene
GeneCards Summary for HDGFL3 Gene
HDGFL3 (HDGF Like 3) is a Protein Coding gene. An important paralog of this gene is PSIP1.
UniProtKB/Swiss-Prot for HDGFL3 Gene
-
Enhances DNA synthesis and may play a role in cell proliferation.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDGFL3 Gene
Genomics for HDGFL3 Gene
Regulatory Elements for HDGFL3 Gene
Enhancers for HDGFL3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HDGFL3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HDGFL3 Gene
- Chromosome:
- 15
- Start:
- 83,112,738 bp from pter
- End:
- 83,208,018 bp from pter
- Size:
- 95,281 bases
- Orientation:
- Minus strand
Genomic View for HDGFL3 Gene
Genes around HDGFL3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q25.2 by Ensembl
- 15q25.2 by Entrez Gene
- 15q25.2 by HGNC
HDGFL3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HDGFL3 Gene
Proteins for HDGFL3 Gene
-
Protein details for HDGFL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y3E1-HDGR3_HUMAN
- Recommended name:
- Hepatoma-derived growth factor-related protein 3
- Protein Accession:
- Q9Y3E1
Protein attributes for HDGFL3 Gene
- Size:
- 203 amino acids
- Molecular mass:
- 22620 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for HDGFL3 Gene
Other Protein References for HDGFL3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HDGFL3
- Novus Biologicals Antibodies for HDGFL3
- Invitrogen Antibodies for HDGFL3
- antibodies-online Antibodies for HDGFL3: See all 35
- GeneTex HDGFRP3 antibody for HDGFL3
Protein Products
-
OriGene Purified Proteins for HDGFL3
- Search Origene for MassSpec and Protein Over-expression Lysates for HDGFL3
- Origene Custom Protein Services for HDGFL3
- antibodies-online Proteins for HDGFL3: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HDGFL3
-
ProSci Proteins for HDGFL3
Assay Products
No data available for DME Specific Peptides for HDGFL3 Gene
Domains & Families for HDGFL3 Gene
Protein Domains for HDGFL3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HDGFL3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y3E1- Family:
-
- Belongs to the HDGF family.
No data available for Gene Families for HDGFL3 Gene
Function for HDGFL3 Gene
Molecular function for HDGFL3 Gene
- UniProtKB/Swiss-Prot Function:
- Enhances DNA synthesis and may play a role in cell proliferation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008017 | microtubule binding | ISS | -- |
| GO:0008083 | growth factor activity | IEA | -- |
| GO:0015631 | tubulin binding | ISS | -- |
Phenotypes for HDGFL3 Gene
- GenomeRNAi human phenotypes for HDGFL3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HDGFL3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HDGFL3 gene
- Search ViGene Biosciences for HDGFL3
CRISPR Products
-
OriGene CRISPR knockouts for HDGFL3
- GenScript: Design CRISPR guide RNA sequences for HDGFL3
miRNA for HDGFL3 Gene
- miRTarBase miRNAs that target HDGFL3
-
- hsa-mir-7856-5p (MIRT545089)
- hsa-mir-4477b (MIRT545090)
- hsa-mir-466 (MIRT545091)
- hsa-mir-299-5p (MIRT545092)
- hsa-mir-4789-3p (MIRT545093)
- hsa-mir-4643 (MIRT545094)
- hsa-mir-541-5p (MIRT545095)
- hsa-mir-6859-5p (MIRT718910)
- hsa-mir-3916 (MIRT718911)
- hsa-mir-3125 (MIRT718912)
- hsa-mir-6856-5p (MIRT718913)
- hsa-mir-6758-5p (MIRT718914)
miRNA Products
- Search ViGene Biosciences for HDGFL3
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for HDGFL3
- Browse OriGene Inhibitory RNA Products For HDGFL3
-
ViGene Biosciences ready-to-package AAV shRNAs for HDGFL3 gene
Clone Products
-
OriGene ORF clones in human for HDGFL3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HDGFL3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HDGFL3
-
ViGene Biosciences adenoviral particle packaged cDNA for HDGFL3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HDGFL3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HDGFL3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HDGFL3 Gene
Localization for HDGFL3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HDGFL3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 10581169 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | ISS | -- |
Pathways & Interactions for HDGFL3 Gene
No Data Available
Interacting Proteins for HDGFL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007026 | negative regulation of microtubule depolymerization | ISS | -- |
| GO:0008283 | cell proliferation | NAS | 10581169 |
| GO:0031175 | neuron projection development | ISS | -- |
| GO:0046785 | microtubule polymerization | ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for HDGFL3 Gene
Transcripts for HDGFL3 Gene
mRNA/cDNA for HDGFL3 Gene
- (2) REFSEQ mRNAs :
- (185) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HDGFL3
- GenScript: Design CRISPR guide RNA sequences for HDGFL3
miRNA Products
- Search ViGene Biosciences for HDGFL3
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for HDGFL3
- Browse OriGene Inhibitory RNA Products For HDGFL3
-
ViGene Biosciences ready-to-package AAV shRNAs for HDGFL3 gene
Clone Products
-
OriGene ORF clones in human for HDGFL3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HDGFL3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HDGFL3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
mRNA Expression by UniProt/SwissProt for HDGFL3 Gene:
Q9Y3E1-HDGR3_HUMAN
Tissue specificity:
Detected in testis, heart, spinal cord and brain.
Evidence on tissue expression from TISSUES for HDGFL3 Gene
- Blood(4.2)
- Lung(4.2)
- Nervous system(3.6)
Primer Products
-
OriGene qPCR primer pairs for HDGFL3
-
OriGene qPCR primer pairs and template standards for HDGFL3
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDGFL3 Gene
Orthologs for HDGFL3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 35 |
|
OneToOne | |
| HDGFRP3 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToOne | |
| HDGFRP3 34 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hdgfrp3 34 35 |
|
||
| Hdgfl3 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Hdgfrp3 34 |
|
||
| cow (Bos Taurus) |
Mammalia | HDGFRP3 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HDGFRP3 34 |
|
||
| -- 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hdgfrp3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CABZ01088864.1 35 |
|
OneToOne | |
| hdgfrp3 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7946 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | C06A5.3 35 |
|
OneToMany |
- Species where no ortholog for HDGFL3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HDGFL3 Gene
Variants for HDGFL3 Gene
| SNP ID | Clin | Chr 15 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000053900 | -- | 83,178,093(+) | GGAAA(A/G)GAAAA | intron-variant | |
| rs1000095506 | -- | 83,132,257(+) | AGATA(C/T)GCCTT | intron-variant, downstream-variant-500B | |
| rs1000125578 | -- | 83,135,458(+) | TTACA(C/T)TTAGA | intron-variant | |
| rs1000150718 | -- | 83,195,942(+) | TACTA(C/T)AACTT | intron-variant | |
| rs1000166847 | -- | 83,146,154(+) | ATCGG(C/T)CCACC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2478815 | CNV | deletion | 19546169 |
| esv3420115 | CNV | insertion | 20981092 |
| esv3569787 | CNV | gain | 25503493 |
| nsv1113726 | CNV | deletion | 24896259 |
| nsv1120052 | OTHER | inversion | 24896259 |
| nsv479714 | CNV | novel sequence insertion | 20440878 |
| nsv94888 | CNV | insertion | 16902084 |
| nsv984103 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.17;
3.85% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HDGFL3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HDGFL3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDGFL3 Gene
Disorders for HDGFL3 Gene
Relevant External Links for HDGFL3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HDGFL3
No disorders were found for HDGFL3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDGFL3 Gene
Publications for HDGFL3 Gene
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
- A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus. (PMID: 10581169) Ikegame K. … Nakamura H. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA. (PMID: 26582913) Cui H. … Sperling S.R. (Nucleic Acids Res. 2016) 3 64
Products for HDGFL3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HDGFL3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HDGFL3
- Search Origene for MassSpec and Protein Over-expression Lysates for HDGFL3
- Origene Custom Protein Services for HDGFL3
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HDGFL3
- Browse OriGene Inhibitory RNA Products For HDGFL3
- OriGene qPCR primer pairs and template standards for HDGFL3
- OriGene qPCR primer pairs for HDGFL3
- OriGene CRISPR knockouts for HDGFL3
- OriGene ORF clones in human for HDGFL3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HDGFL3
- GenScript: Next-day shipping cDNA ORF clone for HDGFL3 in any vector
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- GenScript: Design CRISPR guide RNA sequences for HDGFL3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HDGFL3
- Novus Biologicals proteins and lysates for HDGFL3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for HDGFL3: See all 35
- Search antibodies-online for kits
- antibodies-online Proteins for HDGFL3: See all 8
- Search antibodies-online for peptides
- GeneTex HDGFRP3 antibody for HDGFL3
- Search GeneTex for Proteins for HDGFL3
- ViGene Biosciences adenoviral particle packaged cDNA for HDGFL3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HDGFL3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HDGFL3 gene
- Search ViGene Biosciences for HDGFL3
- Horizon Cell Lines for HDGFL3
- Cyagen custom Knockout/knockin (KOKI) mouse models for HDGFL3
- VectorBuilder custom plasmid, inducible vectors for HDGFL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HDGFL3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HDGFL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (122) diseasecard
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer