Aliases for HDGFL2 Gene
Aliases for HDGFL2 Gene
External Ids for HDGFL2 Gene
- HGNC: 14680
- Entrez Gene: 84717
- Ensembl: ENSG00000167674
- UniProtKB: Q7Z4V5
Summaries for HDGFL2 Gene
-
This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
GeneCards Summary for HDGFL2 Gene
HDGFL2 (HDGF Like 2) is a Protein Coding gene. An important paralog of this gene is PSIP1.
UniProtKB/Swiss-Prot for HDGFL2 Gene
-
Involved in cellular growth control, through the regulation of cyclin D1 expression.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDGFL2 Gene
Genomics for HDGFL2 Gene
Regulatory Elements for HDGFL2 Gene
Enhancers for HDGFL2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HDGFL2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HDGFL2 Gene
- Chromosome:
- 19
- Start:
- 4,472,196 bp from pter
- End:
- 4,502,220 bp from pter
- Size:
- 30,025 bases
- Orientation:
- Plus strand
Genomic View for HDGFL2 Gene
Genes around HDGFL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by Ensembl
- 19p13.3 by Entrez Gene
- 19p13.3 by HGNC
HDGFL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HDGFL2 Gene
Proteins for HDGFL2 Gene
-
Protein details for HDGFL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z4V5-HDGR2_HUMAN
- Recommended name:
- Hepatoma-derived growth factor-related protein 2
- Protein Accession:
- Q7Z4V5
- I3L080
- K7EQZ6
- Q96GI5
- Q9BW08
Protein attributes for HDGFL2 Gene
- Size:
- 671 amino acids
- Molecular mass:
- 74317 Da
- Quaternary structure:
-
- Interacts with HDGF (By similarity). Interacts with trimethylated Lys-36 of histone H3 (H3K36me3). Interacts with trimethylated Lys-79 of histone H3 (H3K79me3), but has higher affinity for H3K36me3. Interacts with IWS1 (PubMed:25689719).
Post-translational modifications for HDGFL2 Gene
Other Protein References for HDGFL2 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HDGFL2
- Novus Biologicals Antibodies for HDGFL2
-
Abcam antibodies for HDGFL2
- Invitrogen Antibodies for HDGFL2
- antibodies-online Antibodies for HDGFL2: See all 42
- GeneTex HDGFRP2 antibody for HDGFL2
-
Custom Antibody ServicesProSci Antibodies for HDGFL2
Protein Products
- R&D Systems Proteins and Enzymes for HDGFL2 (HRP-2)
-
OriGene Purified Proteins for HDGFL2
- Search Origene for MassSpec and Protein Over-expression Lysates for HDGFL2
- Origene Custom Protein Services for HDGFL2
- antibodies-online Proteins for HDGFL2: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HDGFL2
Assay Products
No data available for DME Specific Peptides for HDGFL2 Gene
Domains & Families for HDGFL2 Gene
Protein Domains for HDGFL2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HDGFL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7Z4V5- Family:
-
- Belongs to the HDGF family.
No data available for Gene Families for HDGFL2 Gene
Function for HDGFL2 Gene
Molecular function for HDGFL2 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in cellular growth control, through the regulation of cyclin D1 expression.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 21044950 |
Phenotypes for HDGFL2 Gene
- MGI mutant phenotypes for HDGFL2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HDGFL2:
Animal Models for HDGFL2 Gene
- MGI Knock Outs for HDGFL2:
-
- Hdgfl2 tm1Lex
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HDGFL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HDGFL2 gene
- Search ViGene Biosciences for HDGFL2
CRISPR Products
-
OriGene CRISPR knockouts for HDGFL2
- GenScript: Design CRISPR guide RNA sequences for HDGFL2
miRNA for HDGFL2 Gene
- miRTarBase miRNAs that target HDGFL2
-
- hsa-mir-4423-3p (MIRT551586)
- hsa-mir-3148 (MIRT551587)
- hsa-mir-873-5p (MIRT551588)
- hsa-mir-449c-5p (MIRT551589)
- hsa-mir-34b-5p (MIRT551590)
- hsa-mir-2682-5p (MIRT551591)
- hsa-mir-940 (MIRT551592)
- hsa-mir-6893-5p (MIRT551593)
- hsa-mir-6808-5p (MIRT551594)
- hsa-mir-6511a-5p (MIRT551595)
- hsa-mir-1910-3p (MIRT551596)
- hsa-mir-548as-3p (MIRT551597)
- hsa-mir-548z (MIRT551598)
- hsa-mir-548h-3p (MIRT551599)
- hsa-mir-548d-3p (MIRT551600)
- hsa-mir-548bb-3p (MIRT551601)
- hsa-mir-548ac (MIRT551602)
miRNA Products
- Search ViGene Biosciences for HDGFL2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HDGFL2
- Browse OriGene Inhibitory RNA Products For HDGFL2
-
ViGene Biosciences ready-to-package AAV shRNAs for HDGFL2 gene
Cell Line Products
-
Horizon Cell Lines for HDGFL2
-
ViGene Biosciences adenoviral particle packaged cDNA for HDGFL2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HDGFL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HDGFL2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HDGFL2 Gene
Localization for HDGFL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HDGFL2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 2 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for HDGFL2 Gene
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030307 | positive regulation of cell growth | IMP | 25689719 |
No data available for Pathways by source and SIGNOR curated interactions for HDGFL2 Gene
Transcripts for HDGFL2 Gene
mRNA/cDNA for HDGFL2 Gene
- (6) REFSEQ mRNAs :
- (177) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HDGFL2
- GenScript: Design CRISPR guide RNA sequences for HDGFL2
miRNA Products
- Search ViGene Biosciences for HDGFL2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HDGFL2
- Browse OriGene Inhibitory RNA Products For HDGFL2
-
ViGene Biosciences ready-to-package AAV shRNAs for HDGFL2 gene
Flow Cytometry Products
Expression for HDGFL2 Gene
mRNA Expression by UniProt/SwissProt for HDGFL2 Gene:
Q7Z4V5-HDGR2_HUMAN
Tissue specificity:
Widely expressed. High expression is found in heart, skeletal muscle, ovary and testis. Overexpression is frequently observed in hepatocellular carcinoma samples.
Evidence on tissue expression from TISSUES for HDGFL2 Gene
- Kidney(4.4)
- Muscle(4.4)
- Liver(4.3)
- Nervous system(2.9)
Primer Products
-
OriGene qPCR primer pairs for HDGFL2
-
OriGene qPCR primer pairs and template standards for HDGFL2
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDGFL2 Gene
Orthologs for HDGFL2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC738335 34 |
|
||
| -- 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToOne | |
| HDGFRP2 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToOne | |
| HDGFRP2 34 |
|
||||
| mouse (Mus musculus) |
Mammalia | Hdgfrp2 34 35 |
|
||
| Hdgfl2 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Hdgfrp2 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToOne | |
| LOC772302 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | MGC75972 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hdgfrp2 35 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG7946 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | C06A5.3 35 |
|
OneToMany |
- Species where no ortholog for HDGFL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HDGFL2 Gene
Variants for HDGFL2 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000015291 | -- | 4,484,526(+) | CAGAG(G/T)CTTCG | intron-variant | |
| rs1000044027 | -- | 4,471,107(+) | CCCCG(C/T)TCCTG | upstream-variant-2KB | |
| rs1000184050 | -- | 4,478,798(+) | TTCTG(C/T)CTCAG | intron-variant | |
| rs1000243937 | -- | 4,472,246(+) | GGCGT(C/T)CCGCT | upstream-variant-2KB, utr-variant-5-prime | |
| rs1000265299 | -- | 4,495,145(+) | CACTC(C/T)GGGAG | intron-variant |
Residual Variation Intolerance Score:
30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.60;
45.05% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HDGFL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HDGFL2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDGFL2 Gene
Disorders for HDGFL2 Gene
Relevant External Links for HDGFL2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HDGFL2
No disorders were found for HDGFL2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDGFL2 Gene
Publications for HDGFL2 Gene
- Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. (PMID: 16337983) Vandegraaff N. … Engelman A. (Virology 2006) 2 3 22 64
- Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase. (PMID: 15371438) Cherepanov P. … Engelman A. (J. Biol. Chem. 2004) 2 3 22 64
- HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma. (PMID: 25689719) Gao K. … Zhang P. (Biochem. Biophys. Res. Commun. 2015) 3 4 64
- Structural and histone binding ability characterizations of human PWWP domains. (PMID: 21720545) Wu H. … Min J. (PLoS ONE 2011) 3 4 64
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
Products for HDGFL2 Gene
- Browse R&D Systems for Antibodies
- R&D Systems Proteins and Enzymes for HDGFL2 (HRP-2)
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HDGFL2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HDGFL2
- Search Origene for MassSpec and Protein Over-expression Lysates for HDGFL2
- Origene Custom Protein Services for HDGFL2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HDGFL2
- Browse OriGene Inhibitory RNA Products For HDGFL2
- OriGene qPCR primer pairs and template standards for HDGFL2
- OriGene qPCR primer pairs for HDGFL2
- OriGene CRISPR knockouts for HDGFL2
- OriGene ORF clones in human for HDGFL2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for HDGFL2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HDGFL2
- GenScript Custom Assay Services for HDGFL2
- GenScript Custom overexpressing Cell Line Services for HDGFL2
- GenScript: Design CRISPR guide RNA sequences for HDGFL2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HDGFL2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for HDGFL2: See all 42
- Search antibodies-online for kits
- antibodies-online Proteins for HDGFL2: See all 6
- Search antibodies-online for peptides
- GeneTex HDGFRP2 antibody for HDGFL2
- Search GeneTex for Proteins for HDGFL2
- ViGene Biosciences adenoviral particle packaged cDNA for HDGFL2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HDGFL2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HDGFL2 gene
- Search ViGene Biosciences for HDGFL2
- Custom Antibody ServicesProSci Antibodies for HDGFL2
- Search for HDGFL2 Proteins at ProSci
- Horizon Cell Lines for HDGFL2
- Cyagen custom Knockout/knockin (KOKI) mouse models for HDGFL2
- VectorBuilder custom plasmid, inducible vectors for HDGFL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HDGFL2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HDGFL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
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- (15) Blocks
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- (24) DrugBank
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- (28) RNAdb
- (29) ASD
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- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
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- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (100) COMPARTMENTS
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