Aliases for HDGFL1 Gene
Aliases for HDGFL1 Gene
External Ids for HDGFL1 Gene
- HGNC: 21095
- Entrez Gene: 154150
- Ensembl: ENSG00000112273
- UniProtKB: Q5TGJ6
Previous HGNC Symbols for HDGFL1 Gene
- PWWP1
Previous GeneCards Identifiers for HDGFL1 Gene
- GC06P022678
Summaries for HDGFL1 Gene
GeneCards Summary for HDGFL1 Gene
HDGFL1 (HDGF Like 1) is a Protein Coding gene. An important paralog of this gene is HDGF.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDGFL1 Gene
Genomics for HDGFL1 Gene
Regulatory Elements for HDGFL1 Gene
Enhancers for HDGFL1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G022612 | 1 | Ensembl ENCODE | 11.5 | +44.2 | 44238 | 2.2 | ZBTB21 JUN ZSCAN4 INSM2 ZEB1 HIC1 FOS MAFK BHLHE40 ZEB2 | HDGFL1 GC06M022498 ENSG00000228772 |
| GH06G022655 | 0.7 | ENCODE | 10.7 | +88.2 | 88169 | 3.3 | PKNOX1 TBL1XR1 MTA2 NR2F1 BHLHE40 TRIM22 DPF2 TBX21 EP300 ARID3A | HDGFL1 LOC102724736 LOC105374973 |
| GH06G022631 | 0.2 | ENCODE | 10.8 | +61.9 | 61898 | 0.3 | HDGFL1 GC06M022498 ENSG00000228772 | |
| GH06G022654 | 0.2 | ENCODE | 10.7 | +85.0 | 84998 | 0.2 | HDGFL1 LOC102724736 LOC105374973 | |
| GH06G022470 | 1 | Ensembl ENCODE | 0.1 | -98.1 | -98149 | 1.4 | CTCF FOXA2 NFIB JUN MAX FEZF1 RAD21 YY1 ZNF335 GATA2 | PIR44029 HDGFL1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HDGFL1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HDGFL1 gene promoter:
Regulatory Element Products
Genomic Location for HDGFL1 Gene
- Chromosome:
- 6
- Start:
- 22,569,449 bp from pter
- End:
- 22,571,666 bp from pter
- Size:
- 2,218 bases
- Orientation:
- Plus strand
Genomic View for HDGFL1 Gene
Genes around HDGFL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.3 by Ensembl
- 6p22.3 by Entrez Gene
- 6p22.3 by HGNC
HDGFL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HDGFL1 Gene
Proteins for HDGFL1 Gene
-
Protein details for HDGFL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5TGJ6-HDGL1_HUMAN
- Recommended name:
- Hepatoma-derived growth factor-like protein 1
- Protein Accession:
- Q5TGJ6
- Q96MJ6
Protein attributes for HDGFL1 Gene
- Size:
- 251 amino acids
- Molecular mass:
- 27234 Da
- Quaternary structure:
- No Data Available
Protein Expression for HDGFL1 Gene
Post-translational modifications for HDGFL1 Gene
Other Protein References for HDGFL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HDGFL1
- Invitrogen Antibodies for HDGFL1
- Search GeneTex for Antibodies for HDGFL1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HDGFL1
- Origene Custom Protein Services for HDGFL1
- Novus Biologicals proteins for HDGFL1
- ProSpec Recombinant Proteins for HDGFL1
- Search GeneTex for Proteins for HDGFL1
Assay Products
No data available for DME Specific Peptides for HDGFL1 Gene
Domains & Families for HDGFL1 Gene
Gene Families for HDGFL1 Gene
Protein Domains for HDGFL1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HDGFL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5TGJ6- Family:
-
- Belongs to the HDGF family.
Function for HDGFL1 Gene
Phenotypes for HDGFL1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HDGFL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HDGFL1 gene
- Search ViGene Biosciences for HDGFL1
CRISPR Products
-
OriGene CRISPR knockouts for HDGFL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HDGFL1
- GenScript: Design CRISPR guide RNA sequences for HDGFL1
miRNA Products
- Search ViGene Biosciences for HDGFL1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HDGFL1
- Browse OriGene Inhibitory RNA Products For HDGFL1
-
ViGene Biosciences ready-to-package AAV shRNAs for HDGFL1 gene
Clone Products
-
OriGene ORF clones in human for HDGFL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HDGFL1
-
ViGene Biosciences adenoviral particle packaged cDNA for HDGFL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HDGFL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HDGFL1 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HDGFL1 Gene
Localization for HDGFL1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 3 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HDGFL1 Gene
Transcripts for HDGFL1 Gene
mRNA/cDNA for HDGFL1 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HDGFL1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HDGFL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HDGFL1
- GenScript: Design CRISPR guide RNA sequences for HDGFL1
miRNA Products
- Search ViGene Biosciences for HDGFL1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HDGFL1
- Browse OriGene Inhibitory RNA Products For HDGFL1
-
ViGene Biosciences ready-to-package AAV shRNAs for HDGFL1 gene
Clone Products
-
OriGene ORF clones in human for HDGFL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HDGFL1 Gene
mRNA differential expression in normal tissues according to GTEx for HDGFL1 Gene
This gene is overexpressed in Testis (x52.2).
This gene is overexpressed in Testis (36.9) and Ovary (31.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HDGFL1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HDGFL1 Gene:
HDGFL1SOURCE GeneReport for Unigene cluster for HDGFL1 Gene:
Hs.629246Primer Products
-
OriGene qPCR primer pairs for HDGFL1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDGFL1 Gene
Orthologs for HDGFL1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HDGFL1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HDGFL1 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hdgfl1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | WU:FC32F04 35 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG7946 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | C06A5.3 35 |
|
OneToMany |
- Species where no ortholog for HDGFL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for HDGFL1 Gene
Variants for HDGFL1 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000464669 | -- | 22,570,748(+) | AACCT(C/G)TGCTT | intron-variant, utr-variant-3-prime | |
| rs1000502278 | -- | 22,569,112(+) | TCGGG(A/G)CCTAC | intron-variant, upstream-variant-2KB | |
| rs1001535947 | -- | 22,568,167(+) | TTAGA(A/G)TTTTA | intron-variant, upstream-variant-2KB | |
| rs1002135267 | -- | 22,571,746(+) | CTTGT(A/G)TTAAA | intron-variant, downstream-variant-500B | |
| rs1002470459 | -- | 22,570,476(+) | CTGCC(A/G)GGCCC | intron-variant, utr-variant-3-prime |
Gene Damage Index Score:
6.99;
80.00% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HDGFL1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HDGFL1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDGFL1 Gene
Disorders for HDGFL1 Gene
Relevant External Links for HDGFL1
No disorders were found for HDGFL1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDGFL1 Gene
Publications for HDGFL1 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Genome-wide admixture and association study of serum iron, ferritin, transferrin saturation and total iron binding capacity in African Americans. (PMID: 25224454) Li J. … Lange E.M. (Hum. Mol. Genet. 2015) 3 64
- Genome-wide association study of parity in Bangladeshi women. (PMID: 25742292) Aschebrook-Kilfoy B. … Ahsan H. (PLoS ONE 2015) 3 64
- Mild intellectual disability associated with a progeny of father-daughter incest: genetic and environmental considerations. (PMID: 20509080) Ansermet F. … Paoloni-Giacobino A. (J Child Sex Abus 2010) 3 64
- A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PMID: 19875614) Paterson A.D. … Bull S.B. (Diabetes 2010) 46 64
Products for HDGFL1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HDGFL1
- Origene Custom Protein Services for HDGFL1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HDGFL1
- Browse OriGene Inhibitory RNA Products For HDGFL1
- OriGene qPCR primer pairs for HDGFL1
- OriGene CRISPR knockouts for HDGFL1
- OriGene ORF clones in human for HDGFL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HDGFL1
- GenScript: Next-day shipping cDNA ORF clone for HDGFL1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HDGFL1
- GenScript Custom Assay Services for HDGFL1
- GenScript Custom overexpressing Cell Line Services for HDGFL1
- GenScript: Design CRISPR guide RNA sequences for HDGFL1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HDGFL1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HDGFL1
- Novus Biologicals proteins for HDGFL1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for HDGFL1
- ViGene Biosciences adenoviral particle packaged cDNA for HDGFL1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HDGFL1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HDGFL1 gene
- Search ViGene Biosciences for HDGFL1
- Horizon Cell Lines for HDGFL1
- Cyagen custom Knockout/knockin (KOKI) mouse models for HDGFL1
- VectorBuilder custom plasmid, inducible vectors for HDGFL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HDGFL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HDGFL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer