HDGFL1 Gene
protein-coding GIFtS: 41
GCID: GC06P022569
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hepatoma derived growth factor-like 1(Previous name: PWWP domain containing 1 )
(Previous symbol: PWWP1)
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Aliases
for HDGFL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hepatoma Derived Growth Factor-Like 11 2 | | PWWP Domain-Containing Protein 12 3 | | PWWP11 2 3 | | HDGF (Hepatoma-Derived Growth Factor) Like2 | | DJ309H15.11 | | Hepatoma-Derived Growth Factor-Like Protein 12 | | PWWP Domain Containing 11 2 | | |
Export aliases for HDGFL1 gene to outside databasesPrevious GC identifer: GC06P022678 |
Summaries
for HDGFL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HDGFL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HDGFL1 gene promoter:
Max1 POU2F1 HFH-1 POU2F1a c-Myb c-Myc Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HDGFL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDGFL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.3 Ensembl cytogenetic band: 6p22.3 HGNC cytogenetic band: 6p22.2HDGFL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P022569: view genomic region
(about GC identifiers)
Start:
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22,569,678 bp from pter |
End:
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22,571,892 bp from pter |
Size:
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2,215 bases |
Orientation:
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plus strand |
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Proteins
for HDGFL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HDGL1_HUMAN, Q5TGJ6 (See
protein sequence)Recommended Name: Hepatoma-derived growth factor-like protein 1 Size: 251 amino acids; 27234 Da
Secondary accessions: Q96MJ6Explore the universe of human proteins at neXtProt for HDGFL1: NX_Q5TGJ6
HDGFL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612641.2
ENSEMBL proteins: ENSP00000230012 ENSP00000442129
Human Recombinant Protein Products:
HDGFL1 Antibody Products:
Assay Products for HDGFL1: |
Protein
Domains /
Families
for HDGFL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HDGFL1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5TGJ6ProtoNet protein and cluster: Q5TGJ6 1 Blocks protein family: IPB000313 PWWP domain
UniProtKB/Swiss-Prot: HDGL1_HUMAN, Q5TGJ6Similarity: Belongs to the HDGF familySimilarity: Contains 1 PWWP domain |
Function
for HDGFL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDGFL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDGFL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HDGFL1 (NM_138574) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HDGFL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDGFL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDGFL1 |
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Pathways & Interactions
for HDGFL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HDGFL1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for HDGFL1 (ENSP000002300124) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0034504 | protein localization to nucleus |
IEA | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IEA | -- |
HDGFL1 for ontologies About GeneDecksing
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Drugs & Compounds
for HDGFL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HDGFL1
Search CenterWatch for drugs/clinical trials and news about HDGFL1 / HDGL1
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Transcripts
for HDGFL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HDGFL1 gene: NM_138574.2 Unigene Cluster for HDGFL1: Hepatoma derived growth factor-like 1 Hs.629246 [show with all ESTs]Unigene Representative Sequence: AK0568242 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000230012(uc003nds.3) ENST00000510882
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDGFL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDGFL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HDGFL1 (NM_138574) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HDGFL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDGFL1 |
Additional cDNA sequence: AK056824.1 AK302110.1 1 DOTS entry: DT.306060 1 AceView cDNA sequence: CD359616
GeneLoc Exon Structure
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Expression
for HDGFL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HDGFL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGGAATGC
About this image
See HDGFL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HDGFL1
SOURCE GeneReport for Unigene cluster: Hs.629246
SABiosciences Custom PCR Arrays for HDGFL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HDGFL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HDGFL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDGFL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDGFL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDGFL1 |
Orthologs
for HDGFL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HDGFL1 gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for HDGFL1 (if available)
TreeFam Gene Tree for HDGFL1 (if available) |
Paralogs
for HDGFL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HDGFL1 gene
- HDGF2 PSIP12 HDGFRP32 HDGFRP22
4 SIMAP similar genes for HDGFL1 using alignment to 1 protein entry: HDGL1_HUMAN:HDGF HDGFRP2 HDGFRP3 PSIP1
HDGFL1 for paralogs About GeneDecksing
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Genomic Variants
for HDGFL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HDGFL1 (22569678 - 22571892 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HDGFL1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HDGFL1 |
|
Disorders
/ Diseases
for HDGFL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HDGFL1 for disorders About GeneDecksing
1  disease for HDGFL1: About MalaCardsintellectual disability
Export disorders for HDGFL1 gene to outside databases
|
Publications
for HDGFL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HDGFL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HDGFL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Mild intellectual disability associated with a progen y of father-daughter incest: genetic and environmental considerations. (PubMed id 20509080)1 Ansermet F....Paoloni-Giacobino A. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- The monomer-dimer equilibrium of stromal cell-derived factor-1 (CXCL 12) is altered by pH, phosphate, sulfate, and heparin. (PubMed id 15741341)9 Veldkamp C.T....Volkman B.F. (2005)
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External Searches for HDGFL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing HDGFL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing HDGFL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HDGFL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HDGFL1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for HDGFL1 gene:
Search GeneIP for patents involving HDGFL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HDGFL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HDGFL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDGFL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HDGFL1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HDGFL1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDGFL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDGFL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HDGFL1 | | OriGene Custom Protein Services for HDGFL1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HDGFL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HDGFL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDGFL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDGFL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDGFL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDGFL1 |
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| | | | Search Tocris compounds for HDGFL1 |
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 | | | HDGFL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDGFL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for HDGFL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDGFL1 |
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