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Aliases for HDGFL1 Gene

Aliases for HDGFL1 Gene

  • HDGF Like 1 2 3
  • Hepatoma Derived Growth Factor-Like 1 2 3 5
  • PWWP Domain-Containing Protein 1 3 4
  • PWWP Domain Containing 1 2 3
  • PWWP1 3 4
  • Hepatoma-Derived Growth Factor-Like Protein 1 3
  • HDGF (Hepatoma-Derived Growth Factor) Like 3
  • Testicular Tissue Protein Li 84 3
  • DJ309H15.1 3
  • Hdgfrp1 3
  • HRP-1 3

External Ids for HDGFL1 Gene

Previous HGNC Symbols for HDGFL1 Gene

  • PWWP1

Previous GeneCards Identifiers for HDGFL1 Gene

  • GC06P022678

Summaries for HDGFL1 Gene

GeneCards Summary for HDGFL1 Gene

HDGFL1 (HDGF Like 1) is a Protein Coding gene. An important paralog of this gene is HDGF.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDGFL1 Gene

Genomics for HDGFL1 Gene

Regulatory Elements for HDGFL1 Gene

Enhancers for HDGFL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G022612 1 Ensembl ENCODE 11.5 +44.2 44238 2.2 ZBTB21 JUN ZSCAN4 INSM2 ZEB1 HIC1 FOS MAFK BHLHE40 ZEB2 HDGFL1 GC06M022498 ENSG00000228772
GH06G022655 0.7 ENCODE 10.7 +88.2 88169 3.3 PKNOX1 TBL1XR1 MTA2 NR2F1 BHLHE40 TRIM22 DPF2 TBX21 EP300 ARID3A HDGFL1 LOC102724736 LOC105374973
GH06G022631 0.2 ENCODE 10.8 +61.9 61898 0.3 HDGFL1 GC06M022498 ENSG00000228772
GH06G022654 0.2 ENCODE 10.7 +85.0 84998 0.2 HDGFL1 LOC102724736 LOC105374973
GH06G022446 1 Ensembl ENCODE 0.1 -121.4 -121419 2.6 JUN MAX MAFG REST NR2F2 MAFF JUND ZNF316 GATA2 SMARCA4 PIR44029 HDGFL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HDGFL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HDGFL1 Gene

Chromosome:
6
Start:
22,569,449 bp from pter
End:
22,571,666 bp from pter
Size:
2,218 bases
Orientation:
Plus strand

Genomic View for HDGFL1 Gene

Genes around HDGFL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDGFL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDGFL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDGFL1 Gene

Proteins for HDGFL1 Gene

  • Protein details for HDGFL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TGJ6-HDGL1_HUMAN
    Recommended name:
    Hepatoma-derived growth factor-like protein 1
    Protein Accession:
    Q5TGJ6
    Secondary Accessions:
    • Q96MJ6

    Protein attributes for HDGFL1 Gene

    Size:
    251 amino acids
    Molecular mass:
    27234 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HDGFL1 Gene

Post-translational modifications for HDGFL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HDGFL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HDGFL1 Gene

Domains & Families for HDGFL1 Gene

Protein Domains for HDGFL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HDGFL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TGJ6

UniProtKB/Swiss-Prot:

HDGL1_HUMAN :
  • Belongs to the HDGF family.
Family:
  • Belongs to the HDGF family.
genes like me logo Genes that share domains with HDGFL1: view

Function for HDGFL1 Gene

genes like me logo Genes that share phenotypes with HDGFL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HDGFL1 Gene

Localization for HDGFL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDGFL1 gene
Compartment Confidence
nucleus 3
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HDGFL1 Gene

Pathways & Interactions for HDGFL1 Gene

SuperPathways for HDGFL1 Gene

No Data Available

Interacting Proteins for HDGFL1 Gene

Selected Interacting proteins: Q5TGJ6-HDGL1_HUMAN for HDGFL1 Gene via IID

Gene Ontology (GO) - Biological Process for HDGFL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HDGFL1 Gene

Drugs & Compounds for HDGFL1 Gene

No Compound Related Data Available

Transcripts for HDGFL1 Gene

mRNA/cDNA for HDGFL1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HDGFL1 Gene

Hepatoma derived growth factor-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDGFL1 Gene

No ASD Table

Relevant External Links for HDGFL1 Gene

GeneLoc Exon Structure for
HDGFL1
ECgene alternative splicing isoforms for
HDGFL1

Expression for HDGFL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HDGFL1 Gene

mRNA differential expression in normal tissues according to GTEx for HDGFL1 Gene

This gene is overexpressed in Testis (x52.2).

Protein differential expression in normal tissues from HIPED for HDGFL1 Gene

This gene is overexpressed in Testis (36.9) and Ovary (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HDGFL1 Gene



Protein tissue co-expression partners for HDGFL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HDGFL1 Gene:

HDGFL1

SOURCE GeneReport for Unigene cluster for HDGFL1 Gene:

Hs.629246
genes like me logo Genes that share expression patterns with HDGFL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDGFL1 Gene

Orthologs for HDGFL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HDGFL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDGFL1 35 34
  • 95.31 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HDGFL1 35
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hdgfl1 35
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 41 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii WU:FC32F04 35
  • 8 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7946 35
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06A5.3 35
  • 7 (a)
OneToMany
Species where no ortholog for HDGFL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HDGFL1 Gene

ENSEMBL:
Gene Tree for HDGFL1 (if available)
TreeFam:
Gene Tree for HDGFL1 (if available)

Paralogs for HDGFL1 Gene

Paralogs for HDGFL1 Gene

(4) SIMAP similar genes for HDGFL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HDGFL1: view

Variants for HDGFL1 Gene

Sequence variations from dbSNP and Humsavar for HDGFL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000464669 -- 22,570,748(+) AACCT(C/G)TGCTT intron-variant, utr-variant-3-prime
rs1000502278 -- 22,569,112(+) TCGGG(A/G)CCTAC intron-variant, upstream-variant-2KB
rs1001535947 -- 22,568,167(+) TTAGA(A/G)TTTTA intron-variant, upstream-variant-2KB
rs1002135267 -- 22,571,746(+) CTTGT(A/G)TTAAA intron-variant, downstream-variant-500B
rs1002470459 -- 22,570,476(+) CTGCC(A/G)GGCCC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HDGFL1 Gene

Variant ID Type Subtype PubMed ID
nsv830605 CNV gain 17160897

Variation tolerance for HDGFL1 Gene

Gene Damage Index Score: 6.99; 80.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HDGFL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HDGFL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDGFL1 Gene

Disorders for HDGFL1 Gene

Relevant External Links for HDGFL1

Genetic Association Database (GAD)
HDGFL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HDGFL1

No disorders were found for HDGFL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDGFL1 Gene

Publications for HDGFL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Genome-wide admixture and association study of serum iron, ferritin, transferrin saturation and total iron binding capacity in African Americans. (PMID: 25224454) Li J. … Lange E.M. (Hum. Mol. Genet. 2015) 3 64
  3. Genome-wide association study of parity in Bangladeshi women. (PMID: 25742292) Aschebrook-Kilfoy B. … Ahsan H. (PLoS ONE 2015) 3 64
  4. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PMID: 19875614) Paterson A.D. … Bull S.B. (Diabetes 2010) 46 64
  5. Mild intellectual disability associated with a progeny of father-daughter incest: genetic and environmental considerations. (PMID: 20509080) Ansermet F. … Paoloni-Giacobino A. (J Child Sex Abus 2010) 3 64

Products for HDGFL1 Gene

Sources for HDGFL1 Gene

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