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Aliases for HDGFL1 Gene

Aliases for HDGFL1 Gene

  • Hepatoma Derived Growth Factor-Like 1 2 3
  • PWWP Domain-Containing Protein 1 3 4
  • PWWP Domain Containing 1 2 3
  • PWWP1 3 4
  • Hepatoma-Derived Growth Factor-Like Protein 1 3
  • HDGF (Hepatoma-Derived Growth Factor) Like 3
  • DJ309H15.1 3

External Ids for HDGFL1 Gene

Previous Symbols for HDGFL1 Gene

  • PWWP1

Summaries for HDGFL1 Gene

GeneCards Summary for HDGFL1 Gene

HDGFL1 (Hepatoma Derived Growth Factor-Like 1) is a Protein Coding gene. An important paralog of this gene is PSIP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDGFL1 Gene

Genomics for HDGFL1 Gene

Genomic Location for HDGFL1 Gene

Start:
22,569,449 bp from pter
End:
22,571,666 bp from pter
Size:
2,218 bases
Orientation:
Plus strand

Genomic View for HDGFL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HDGFL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDGFL1 Gene

Regulatory Elements for HDGFL1 Gene

Proteins for HDGFL1 Gene

  • Protein details for HDGFL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TGJ6-HDGL1_HUMAN
    Recommended name:
    Hepatoma-derived growth factor-like protein 1
    Protein Accession:
    Q5TGJ6
    Secondary Accessions:
    • Q96MJ6

    Protein attributes for HDGFL1 Gene

    Size:
    251 amino acids
    Molecular mass:
    27234 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HDGFL1 Gene

Proteomics data for HDGFL1 Gene at MOPED

Post-translational modifications for HDGFL1 Gene

No Post-translational modifications

Other Protein References for HDGFL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HDGFL1 Gene

Domains for HDGFL1 Gene

Protein Domains for HDGFL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HDGFL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TGJ6

UniProtKB/Swiss-Prot:

HDGL1_HUMAN
Domain:
  • Contains 1 PWWP domain.:
    • Q5TGJ6
Family:
  • Belongs to the HDGF family.:
    • Q5TGJ6
genes like me logo Genes that share domains with HDGFL1: view

No data available for Gene Families for HDGFL1 Gene

Function for HDGFL1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HDGFL1 Gene

Localization for HDGFL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HDGFL1 Gene COMPARTMENTS Subcellular localization image for HDGFL1 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for HDGFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HDGFL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HDGFL1 Gene

Pathways for HDGFL1 Gene

SuperPathways for HDGFL1 Gene

No Data Available

Interacting Proteins for HDGFL1 Gene

Gene Ontology (GO) - Biological Process for HDGFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0034504 protein localization to nucleus IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with HDGFL1: view

No data available for Pathways by source for HDGFL1 Gene

Transcripts for HDGFL1 Gene

mRNA/cDNA for HDGFL1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HDGFL1 Gene

Hepatoma derived growth factor-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HDGFL1 Gene

No ASD Table

Relevant External Links for HDGFL1 Gene

GeneLoc Exon Structure for
HDGFL1
ECgene alternative splicing isoforms for
HDGFL1

Expression for HDGFL1 Gene

mRNA expression in normal human tissues for HDGFL1 Gene

mRNA differential expression in normal tissues according to GTEx for HDGFL1 Gene

This gene is overexpressed in Testis (52.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HDGFL1 Gene

SOURCE GeneReport for Unigene cluster for HDGFL1 Gene Hs.629246

genes like me logo Genes that share expressions with HDGFL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HDGFL1 Gene

Orthologs for HDGFL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HDGFL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDGFL1 35
  • 95.31 (n)
  • 90.76 (a)
HDGFL1 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HDGFL1 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hdgfl1 16
Hdgfl1 36
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 41 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii WU:FC32F04 36
  • 8 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7946 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06A5.3 36
  • 7 (a)
OneToMany
Species with no ortholog for HDGFL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HDGFL1 Gene

ENSEMBL:
Gene Tree for HDGFL1 (if available)
TreeFam:
Gene Tree for HDGFL1 (if available)

Paralogs for HDGFL1 Gene

Paralogs for HDGFL1 Gene

Selected SIMAP similar genes for HDGFL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HDGFL1: view

Variants for HDGFL1 Gene

Sequence variations from dbSNP and Humsavar for HDGFL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1361697 -- 22,568,305(-) CAGTA(A/C)AACTC upstream-variant-2KB
rs2073030 -- 22,569,405(+) TGCAC(A/T)CTTCG upstream-variant-2KB
rs2076506 - 22,569,835(+) CCCCA(C/T)GGTCC reference, missense
rs2328734 -- 22,568,702(+) AAACA(C/T)GTGTC upstream-variant-2KB
rs3065042 -- 22,568,700(+) GAAAA(-/CA)TGTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HDGFL1 Gene

Variant ID Type Subtype PubMed ID
nsv830605 CNV Gain 17160897

Relevant External Links for HDGFL1 Gene

HapMap Linkage Disequilibrium report
HDGFL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDGFL1 Gene

Disorders for HDGFL1 Gene

Relevant External Links for HDGFL1

Genetic Association Database (GAD)
HDGFL1
genes like me logo Genes that share disorders with HDGFL1: view

No data available for UniProtKB/Swiss-Prot for HDGFL1 Gene

Publications for HDGFL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Mild intellectual disability associated with a progeny of father-daughter incest: genetic and environmental considerations. (PMID: 20509080) Ansermet F. … Paoloni-Giacobino A. (J Child Sex Abus 2010) 3
  4. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin E.J. … Vasan R.S. (BMC Med. Genet. 2007) 48
  5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 48

Products for HDGFL1 Gene

Sources for HDGFL1 Gene

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