Aliases for HDGF Gene
External Ids for HDGF Gene
Previous GeneCards Identifiers for HDGF Gene
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]
GeneCards Summary for HDGF Gene
HDGF (Hepatoma-Derived Growth Factor) is a Protein Coding gene. Diseases associated with HDGF include intrahepatic cholangiocarcinoma and lung cancer. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include poly(A) RNA binding and growth factor activity. An important paralog of this gene is PSIP1.
UniProtKB/Swiss-Prot for HDGF Gene
Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor.