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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HDGF Gene

protein-coding GIFtS: 61
GCID: GC01M156711

hepatoma-derived growth factor

(Previous name: hepatoma-derived growth factor (high-mobility group protein...)

Explore 23 diseases affiliated with
HDGF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Hepatoma-Derived Growth Factor¹ ²
HMG1L2¹ ² ³
High Mobility Group Protein 1-Like 2² ³
HMG-1L2² ³
Hepatoma-Derived Growth Factor (High-Mobility Group Protein 1-Like)¹

External Ids:	HGNC: 4856¹	Entrez Gene: 3068²	Ensembl: ENSG00000143321⁷	OMIM: 600339⁵	UniProtKB: P51858³

Export aliases for HDGF gene to outside databases

Previous GC identifers: GC01M154581 GC01M152477 GC01M153489 GC01M153928 GC01M153524 GC01M154978 GC01M128069

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HDGF:

This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and

DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought

initially to be located on chromosome X, however, that location has been determined to correspond to a related

pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HDGF_HUMAN, P51858

Function: Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor

Gene Wiki entry for HDGF (Hepatoma-derived growth factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HDGF gene promoter:
E2F-3a E2F E2F-1 E2F-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HDGF promoter sequence

Search SABiosciences Chromatin IP Primers for HDGF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDGF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q23 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q21-q23

HDGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDGF gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M156711: view genomic region (about GC identifiers)

Start:	156,711,899 bp from pter	End:	156,736,717 bp from pter
Size:	24,819 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HDGF_HUMAN, P51858 (See protein sequence)

Recommended Name: Hepatoma-derived growth factor

Size: 240 amino acids; 26788 Da

Subunit: Monomer, and domain-swapped homodimer

Subcellular location: Cytoplasm. Nucleus

2 PDB 3D structures from and Proteopedia for HDGF:

1RI0 (3D)

2NLU (3D)

Secondary accessions: B3KU21 D3DVC9 Q5SZ08 Q5SZ09

Alternative splicing: 2 isoforms: P51858-1 P51858-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HDGF: NX_P51858

Post-translational modifications:

Sumoylated with SUMO1. Sumoylation prevents binding to chromatin¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P51858

HDGF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001119522.1 NP_001119523.1 NP_004485.1

ENSEMBL proteins:

ENSP00000349878 ENSP00000357192 ENSP00000357189 ENSP00000443120 ENSP00000416752

Reactome Protein details: P51858
Human Recombinant Protein Products:

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	Novus Biologicals HDGF Proteins Novus Biologicals HDGF Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HDGF

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IEA	--
GO:0017053	transcriptional repressor complex	IDA	19162039

HDGF for ontologies About GeneDecksing

HDGF Antibody Products:

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	Novus Biologicals HDGF Antibodies
	Abcam antibodies for HDGF
	Uscn Antibodies for HDGF
	ThermoFisher Antibodies for HDGF

Assay Products for HDGF:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for HDGF
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HDGF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HDGF for domains About GeneDecksing

1 InterPro domain/family:

IPR000313 PWWP

Graphical View of Domain Structure for InterPro Entry P51858

ProtoNet protein and cluster: P51858

1 Blocks protein family: IPB000313 PWWP domain

UniProtKB/Swiss-Prot: HDGF_HUMAN, P51858

Domain: The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal

region is essentially unstructured

Similarity: Belongs to the HDGF family

Similarity: Contains 1 PWWP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HDGF_HUMAN, P51858

Function: Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor

Genatlas biochemistry entry for HDGF:

hepatoma-derived growth factor,with mitogenic activity for fibroblasts,expressed (in mice) predominantly in testis and

skeletal muscle,to intermediate extents in heart,brain,lung,liver,kidney

miRNA Products:		OriGene 3'-UTR Clone (see all 3): HDGF Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HDGF
		8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate HDGF (see all 53):
		hsa-miR-3685 hsa-miR-15a hsa-miR-139-5p hsa-miR-29a hsa-miR-424 hsa-miR-3909 hsa-miR-761 hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: HDGF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDGF (see all 7) OriGene shRNA RFP: HDGF OriGene siRNA: HDGF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDGF

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HDGF

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 3): HDGF (NM_004494)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HDGF
		Search LifeMap BioReagents cell lines for HDGF

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDGF

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0001106	RNA polymerase II transcription corepressor activity	IDA	19162039
GO:0001222	transcription corepressor binding	IPI	19162039
GO:0003677	DNA binding	IEA	--
GO:0008083	growth factor activity	IEA	--

HDGF for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for HDGF:

Decreased homologous recombina

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Hdgf):

behavior/neurological

HDGF for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			JNK Pathway	0.50

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HDGF (see all 54)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

5 Reactome Pathways for HDGF

	Activation of Chaperone Genes by XBP1(S)
	Metabolism of proteins
	Activation of Chaperones by IRE1alpha
	Expression of HDGF
	Unfolded Protein Response

HDGF for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HDGF

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/213 Interacting proteins for HDGF (P51858³ ENSP00000357189⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 213)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
XBP1	P17861³, ENSP00000216037⁴	I2D: score=1 STRING: ENSP00000216037
KAT5	Q92993³, ENSP00000340330⁴	I2D: score=3 STRING: ENSP00000340330
KAT2A	Q92830³, ENSP00000225916⁴	I2D: score=3 STRING: ENSP00000225916
EMD	P50402³, ENSP00000358857⁴	I2D: score=1 STRING: ENSP00000358857
SMAD4	Q13485³, ENSP00000341551⁴	I2D: score=4 STRING: ENSP00000341551

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	19162039
GO:0006351	transcription, DNA-dependent	--	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006987	activation of signaling protein activity involved in unfolded protein response	TAS	--
GO:0007165	signal transduction	NAS	7929202

HDGF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HDGF for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HDGF

1 HMDB Compound for HDGF About this table

Compound	Synonyms	CAS #	PubMed Ids
Heparin	Arteven (see all 17)	9005-49-6	--

3 Novoseek chemical compound relationships for HDGF gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
agar	26.6	3	19710540 (1), 14985104 (1), 14662017 (1)
vegf	22.7	8	14751852 (2), 18478933 (2), 14662017 (1), 14635185 (1)
bromodeoxyuridine	15.8	5	14751852 (2), 11481329 (1)

Search CenterWatch for drugs/clinical trials and news about HDGF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HDGF gene (3 alternative transcripts):

NM_001126050.1 NM_001126051.1 NM_004494.2

Unigene Cluster for HDGF:

Hepatoma-derived growth factor

Hs.743948 [show with all ESTs]

Unigene Representative Sequence: NM_004494

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000357325(uc009wsd.3 uc001fpy.4) ENST00000368209(uc001fpz.4 uc009wse.3 uc010phr.2)

ENST00000465180(uc009wsf.3) ENST00000482651 ENST00000477306 ENST00000368206

ENST00000469145 ENST00000471377 ENST00000495212 ENST00000537739 ENST00000416666

miRNA Products:		OriGene 3'-UTR Clone (see all 3): HDGF Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HDGF
		8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate HDGF (see all 53):
		hsa-miR-3685 hsa-miR-15a hsa-miR-139-5p hsa-miR-29a hsa-miR-424 hsa-miR-3909 hsa-miR-761 hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: HDGF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDGF (see all 7) OriGene shRNA RFP: HDGF OriGene siRNA: HDGF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDGF

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDGF (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDGF (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): HDGF (NM_004494)
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Additional cDNA sequence:

AK096411.1 AK292325.1 AK298342.1 AK304468.1 AK315514.1 AL833592.1 BC018991.1 D16431.1

24/42 DOTS entries (see all 42):

DT.91918260 DT.100683812 DT.450176 DT.100683801 DT.100683784 DT.100654016 DT.92071669 DT.91666907

DT.95118639 DT.121434813 DT.91881659 DT.121434780 DT.100709116 DT.91913812 DT.91752341 DT.92054608

DT.92071813 DT.100683786 DT.100683800 DT.100683806 DT.121434788 DT.91688246 DT.91850734 DT.95118634

24/890 AceView cDNA sequences (see all 890):

BM548699 AW467460 BE266528 BQ959003 BU170931 AW404035 AI274580 BM474941

AA304055 BQ220033 AA315686 BM477909 BE208620 BP341376 AW951970 BM988502

AA297111 BM801047 AI244414 BU543649 AI571702 T31201 BM851584 BU845561

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for HDGF About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7
SP1:									-				-
SP2:									-				-
SP3:
SP4:			-
SP5:													-

ECgene alternative splicing isoforms for HDGF

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HDGF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTCTCCCT

About this image

HDGF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See HDGF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HDGF

SOURCE GeneReport for Unigene cluster: Hs.743948

UniProtKB/Swiss-Prot: HDGF_HUMAN, P51858

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for HDGF

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDGF

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDGF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HDGF gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HDGF¹	hepatoma-derived growth factor	75.96(n) 74.34(a)		776936 XM_001236426.2 XP_001236427.2
lizard (Anolis carolinensis)	Reptilia	HDGF⁶ --	--	53(a) 2(a)	1 ↔ many possible ortholog	GL343637.1(55672-61499) 2(105347723-105348226)
African clawed frog (Xenopus laevis)	Amphibia	BQ386538.1²	--	80.57(n)		BQ386538.1
fruit fly (Drosophila melanogaster)	Insecta	CG7946⁶	--	11(a)	1 → many	3R(25878236-25880419)
worm (Caenorhabditis elegans)	Secernentea	C06A5.3⁶	--	5(a)	possible ortholog	I(5986494-5990583)

ENSEMBL Gene Tree for HDGF (if available)
TreeFam Gene Tree for HDGF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HDGF gene

PSIP1² HDGFL1² HDGFRP3² HDGFRP2²

4 SIMAP similar genes for HDGF using alignment to 5 protein entries: HDGF_HUMAN (see all proteins):

HDGFRP3 HDGFL1 HDGFRP2 PSIP1

HDGF for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for HDGF
PGOHUM00000242017

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72712150^1,2	C,	--	128069492(+)	`TTTTAA/TAAAAA`	2	--	ds500¹		0	--	--	--	--
rs9842^1,2	C,F,H,	--	128070028(-)	`CTTTCT/GTTTTG`	2	--	ut3¹ trp³		10		NS EA NA	1100
rs73002713^1,2	C,,	--	128070598(+)	`GTGCTG/ACCCCC`	2	--	ut3¹		2		WA	120
rs11556977^1,2	C,F,H,	--	128070882(-)	`CACCTG/TGCTCT`	2	--	ut3¹ ese³		5		NS NA	568
rs11556974^1,2	C	--	128071371(-)	`GCCCGG/ACTCTG`	4	/D /G	mis¹		2		NA	4
rs113137442^1,2	C,F	--	128071373(+)	`GAGCCG/AGGCTC`	4	/P	syn¹		2		WA NA	3524
rs6675747^1,2	C,H	--	128071797(+)	`CCCTGC/TTCTCC`	4	T A	mis¹ ese³ trp³		6		NS EA NA	528
rs112290026^1,2	C	--	128072624(+)	`GCTCAA/C/GCTGAT`	2	--	spd¹		1		CSA	1
rs113283548^1,2	C	--	128072911(+)	`CCACTG/CACGTC`	2	--	int¹		1		CSA	1
rs112880542^1,2	C	--	128072912(+)	`CACTCA/C/TCGTCT`	2	--	spd¹		1		CSA	1

HapMap Linkage Disequilibrium report for HDGF (156711899 - 156736717 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HDGF
1 Indel: 58335

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HDGF for disorders           About GeneDecksing

OMIM gene information: 600339    OMIM disorders: --

20/23 diseases for HDGF (see all 23):    About MalaCards

gastrointestinal stromal tumor chronic myeloid leukemia ulcerative colitis myeloid leukemia

hepatocellular carcinoma keloids esophagitis lung adenocarcinoma

esophageal carcinoma liver cancer colon carcinoma adenocarcinoma

esophageal cancer carcinoma nasopharyngitis pancreatic cancer

leukemia cholangiocarcinoma lung cancer pancreatitis

9 Novoseek disease relationships for HDGF gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatocellular carcinoma	42.7	6	14508832 (1), 19710540 (1), 14535987 (1), 18651222 (1) (see all 6)
nsclc	40.7	13	16397209 (4), 15310766 (3), 20043047 (2), 15870924 (2)
tumors	27	35	15310766 (4), 19279430 (3), 20193688 (2), 14535987 (2) (see all 17)
cancer	18.8	21	19710540 (3), 18651222 (3), 20193688 (2), 17487837 (1) (see all 9)
colitis	16.6	2	12572860 (1)
cancer lung	13.7	7	15870924 (3), 15310766 (1), 18478933 (1), 20193688 (1)
colitis ulcerative	10.3	3	15086185 (2), 12572860 (1)
metastasis	0	4	18823380 (2), 16397209 (1)
carcinoma	0	2	16397032 (1), 17473954 (1)

Export disorders for HDGF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HDGF gene, integrated from 9 sources (see all 107):
(articles sorted by number of sources associating them with HDGF)

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world of online information

Hepatoma-derived growth factor binds DNA through the N-terminal PWWP domain. (PubMed id 17974029)^{1, 2, 9} Yang J. and Everett A.D. (2007)
Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals. (PubMed id 11751870)^{1, 2, 9} Kishima Y.... Nakamura H. (2002)
Mapping of the gene encoding the human hepatoma-derived growth factor (HDGF) with homology to the high-mobility group (HMG)-1 protein to Xq25. (PubMed id 8833162)^{1, 3, 9} Wanschura S....Bullerdiek J. (1996)
Molecular cloning of complementary DNA for a novel human hepatoma- derived growth factor. Its homology with high mobility group-1 protein. (PubMed id 7929202)^{1, 2, 9} Nakamura H.... Kishimoto T. (1994)
SUMOylation of the hepatoma-derived growth factor negatively influences its binding to chromatin. (PubMed id 18331345)^{1, 2} Thakar K.... Dietz F. (2008)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
[Expression of HDGF and its implication in stage I non-small cell lung cancer] (PubMed id 18478933)^{1, 9} Zhou S.J....Liu Z.D. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3068	HGNC: 4856	AceView: HDGF	Ensembl:ENSG00000143321	euGenes: HUgn3068
ECgene: HDGF	H-InvDB: HDGF

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HDGF	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HDGF	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for HDGF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HDGF gene:
Search GeneIP for patents involving HDGF

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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