Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HDGF Gene

protein-coding   GIFtS: 62
GCID: GC01M156711

Hepatoma-Derived Growth Factor

(Previous name: hepatoma-derived growth factor (high-mobility group protein...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hepatoma-Derived Growth Factor1 2
High Mobility Group Protein 1-Like 22 3
HMG-1L22 3
HMG1L22 3
Hepatoma-Derived Growth Factor (High-Mobility Group Protein 1-Like)1
High-Mobility Group Protein 1-Like1

External Ids:    HGNC: 48561   Entrez Gene: 30682   Ensembl: ENSG000001433217   OMIM: 6003395   UniProtKB: P518583   

Export aliases for HDGF gene to outside databases

Previous GC identifers: GC01M154581 GC01M152477 GC01M153489 GC01M153928 GC01M153524 GC01M154978 GC01M128069


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HDGF Gene:
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and
DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought
initially to be located on chromosome X, however, that location has been determined to correspond to a related
pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. (provided
by RefSeq, Jul 2008)

GeneCards Summary for HDGF Gene: 
HDGF (hepatoma-derived growth factor) is a protein-coding gene. Diseases associated with HDGF include gastrointestinal stromal tumor, and keloids, and among its related super-pathways are Rac1 Pathway and Ras Pathway. GO annotations related to this gene include heparin binding and nucleotide binding. An important paralog of this gene is PSIP1.

UniProtKB/Swiss-Prot: HDGF_HUMAN, P51858
Function: Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor

Gene Wiki entry for HDGF (Hepatoma-derived growth factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HDGF gene promoter:
         E2F-3a   E2F   E2F-1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHDGF promoter sequence
   Search SABiosciences Chromatin IP Primers for HDGF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDGF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q23   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q21-q23

HDGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDGF gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156711:  view genomic region     (about GC identifiers)

Start:
156,711,899 bp from pter      End:
156,736,717 bp from pter
Size:
24,819 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HDGF_HUMAN, P51858 (See protein sequence)
Recommended Name: Hepatoma-derived growth factor  
Size: 240 amino acids; 26788 Da
Subunit: Monomer, and domain-swapped homodimer
Subcellular location: Cytoplasm. Nucleus
2 PDB 3D structures from and Proteopedia for HDGF:
1RI0 (3D)        2NLU (3D)    
Secondary accessions: B3KU21 D3DVC9 Q5SZ07 Q5SZ08 Q5SZ09
Alternative splicing: 3 isoforms:  P51858-1   P51858-2   P51858-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for HDGF: NX_P51858

Explore proteomics data for HDGF at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylated with SUMO1. Sumoylation prevents binding to chromatin
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51858

  • HDGF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HDGF Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001119522.1  NP_001119523.1  NP_004485.1  

    ENSEMBL proteins: 
     ENSP00000349878   ENSP00000357192   ENSP00000357189   ENSP00000443120   ENSP00000416752  
    Reactome Protein details: P51858
    Human Recombinant Protein Products for HDGF: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HDGF
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HDGF
    GenScript Custom Purified and Recombinant Proteins Services for HDGF
    Novus Biologicals HDGF Proteins
    Novus Biologicals HDGF Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HDGF 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0017053transcriptional repressor complex IDA19162039

    HDGF for ontologies           About GeneDecksing



    HDGF Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HDGF
    OriGene Antibodies for HDGF
    OriGene Custom Antibody Services for HDGF
    GenScript Custom Superior Antibodies Services for HDGF
    Novus Biologicals HDGF Antibodies
    Abcam antibodies for HDGF
    Cloud-Clone Corp. Antibodies for HDGF 
    ThermoFisher Antibodies for HDGF
    LSBio Antibodies in human, mouse, rat for HDGF 

    Assay Products for HDGF: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HDGF
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HDGF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HDGF 
    Cloud-Clone Corp. CLIAs for HDGF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000313 PWWP

    Graphical View of Domain Structure for InterPro Entry P51858

    ProtoNet protein and cluster: P51858

    1 Blocks protein domain: IPB000313 PWWP domain

    UniProtKB/Swiss-Prot: HDGF_HUMAN, P51858
    Domain: The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal
    region is essentially unstructured
    Similarity: Belongs to the HDGF family
    Similarity: Contains 1 PWWP domain


    HDGF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HDGF_HUMAN, P51858
    Function: Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor

         Genatlas biochemistry entry for HDGF:
    hepatoma-derived growth factor,with mitogenic activity for fibroblasts,expressed (in mice) predominantly in testis
    and skeletal muscle,to intermediate extents in heart,brain,lung,liver,kidney

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0001106RNA polymerase II transcription corepressor activity IDA19162039
    GO:0001222transcription corepressor binding IPI19162039
    GO:0003677DNA binding IEA--
    GO:0008083growth factor activity IEA--
         
    HDGF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HDGF:
     Decreased homologous recombina 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Hdgf):
     behavior/neurological 

    HDGF for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HDGF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HDGF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HDGF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HDGF 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HDGF
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate HDGF (see all 53):
    hsa-miR-3685 hsa-miR-15a hsa-miR-139-5p hsa-miR-29a hsa-miR-424 hsa-miR-3909 hsa-miR-761 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidHDGF 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HDGF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDGF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HDGF
    Sirion Biotech Customized adenovirus for overexpression of HDGF

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HDGF (see all 18)
    OriGene ORF clones in mouse, rat for HDGF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): HDGF (NM_004494)
    Sino Biological Human cDNA Clone for HDGF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDGF
    Sirion Biotech Customized lentivirus for stable overexpression of HDGF 
                         Customized lentivirus expression plasmids for stable overexpression of HDGF 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HDGF
    Search LifeMap BioReagents cell lines for HDGF
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDGF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HDGF About   (see all 14)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HDGF (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


    4        Reactome Pathways for HDGF
        Activation of Chaperone Genes by XBP1(S)
    Metabolism of proteins
    Activation of Chaperones by IRE1alpha
    Unfolded Protein Response



    HDGF for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HDGF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/213 Interacting proteins for HDGF (P518583 ENSP000003571894) via UniProtKB, MINT, STRING, and/or I2D (see all 213)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XBP1P178613, ENSP000002160374I2D: score=1 STRING: ENSP00000216037
    KAT5Q929933, ENSP000003403304I2D: score=3 STRING: ENSP00000340330
    KAT2AQ928303, ENSP000002259164I2D: score=3 STRING: ENSP00000225916
    EMDP504023, ENSP000003588574I2D: score=1 STRING: ENSP00000358857
    SMAD4Q134853, ENSP000003415514I2D: score=4 STRING: ENSP00000341551
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA19162039
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0007165signal transduction NAS7929202
    GO:0008283cell proliferation TAS7929202
    GO:0009987cellular process ----

    HDGF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HDGF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HDGF

    1 HMDB Compound for HDGF    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    3 Novoseek inferred chemical compound relationships for HDGF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    agar 26.6 3 19710540 (1), 14985104 (1), 14662017 (1)
    vegf 22.7 8 14751852 (2), 18478933 (2), 14662017 (1), 14635185 (1)
    bromodeoxyuridine 15.8 5 14751852 (2), 11481329 (1)

    Search CenterWatch for drugs/clinical trials and news about HDGF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HDGF gene (3 alternative transcripts): 
    NM_001126050.1  NM_001126051.1  NM_004494.2  

    Unigene Cluster for HDGF:

    Hepatoma-derived growth factor
    Hs.743948  [show with all ESTs]
    Unigene Representative Sequence: NM_004494
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357325(uc009wsd.3 uc001fpy.4) ENST00000368209(uc001fpz.4 uc009wse.3 uc010phr.2)
    ENST00000465180(uc009wsf.3) ENST00000482651 ENST00000477306 ENST00000368206
    ENST00000469145 ENST00000471377 ENST00000495212 ENST00000537739 ENST00000416666

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HDGF
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate HDGF (see all 53):
    hsa-miR-3685 hsa-miR-15a hsa-miR-139-5p hsa-miR-29a hsa-miR-424 hsa-miR-3909 hsa-miR-761 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidHDGF 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HDGF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDGF
    Clone
    Products:
         
    OriGene clones in human, mouse for HDGF (see all 18)
    OriGene ORF clones in mouse, rat for HDGF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): HDGF (NM_004494)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDGF
    Sirion Biotech Customized lentivirus for stable overexpression of HDGF 
                         Customized lentivirus expression plasmids for stable overexpression of HDGF 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HDGF
    OriGene qSTAR qPCR primer pairs in human, mouse for HDGF
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HDGF
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDGF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDGF

    Additional mRNA sequence: 

    AK096411.1 AK292325.1 AK298342.1 AK304468.1 AK315514.1 AL833592.1 BC018991.1 D16431.1 

    24/42 DOTS entries (see all 42):

    DT.91918260  DT.100683812  DT.450176  DT.100683801  DT.100683784  DT.100654016  DT.92071669  DT.91666907 
    DT.95118639  DT.121434813  DT.91881659  DT.121434780  DT.100709116  DT.91913812  DT.91752341  DT.92054608 
    DT.92071813  DT.100683786  DT.100683800  DT.100683806  DT.121434788  DT.91688246  DT.91850734  DT.95118634 

    24/890 AceView cDNA sequences (see all 890):

    BE791425 BM975710 BX475960 CB133166 BQ223205 BG741400 AA190963 AA310463 
    N58696 AA195390 AA973704 BU553410 AA102218 BQ427659 BE255888 BQ220033 
    BQ940269 W79612 CD365116 AI571387 CB136470 Z43004 AA205098 AA617945 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HDGF    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7
    SP1:                          -           -                           
    SP2:                          -           -                           
    SP3:                                                                  
    SP4:        -                                                         
    SP5:                                      -                           


    ECgene alternative splicing isoforms for HDGF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HDGF expression in normal human tissues (normalized intensities)      HDGF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTCTCCCT
    HDGF Expression
    About this image


    HDGF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Hepatocytes Liver Lobule
             Liver Lobule
             liver ; bile duct cells   

    See HDGF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HDGF

    SOURCE GeneReport for Unigene cluster: Hs.743948

    UniProtKB/Swiss-Prot: HDGF_HUMAN, P51858
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for HDGF
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HDGF
    OriGene qSTAR qPCR primer pairs in human, mouse for HDGF
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HDGF
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDGF
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDGF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDGF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HDGF gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hdgf1 , 5 hepatoma-derived growth factor1, 5 89.03(n)1
    89.45(a)1
      3 (38.78 cM)5
    151911  NM_008231.41  NP_032257.31 
     879063215 
    chicken
    (Gallus gallus)
    Aves HDGF1 hepatoma-derived growth factor 75.96(n)
    74.34(a)
      776936  XM_001236426.2  XP_001236427.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    58(a)
    1 → many
    GL343637.1(52194-61439)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ386538.12   -- 80.57(n)    BQ386538.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79466
    --
    10(a)
    1 → many
    3R(25878236-25880419)


    ENSEMBL Gene Tree for HDGF (if available)
    TreeFam Gene Tree for HDGF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HDGF gene
    PSIP12  HDGFL12  HDGFRP32  HDGFRP22  
    4 SIMAP similar genes for HDGF using alignment to 4 protein entries:     HDGF_HUMAN (see all proteins):
    HDGFRP3    HDGFRP2    HDGFL1    PSIP1

    HDGF for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HDGF
    PGOHUM00000242017


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/247 SNPs in HDGF are shown (see all 247)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107138131,2
    C--156719596(+) TCCCC-/AAGGGC 3 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs1125223681,2
    C--156719596(+) TCCCCC/AAGGGC 3 -- int11Minor allele frequency- A:0.00CSA 1
    rs38064171,2
    C,F,H--163210615(+) CGATAC/ATCGCA 2 -- ds500120Minor allele frequency- A:0.16NS EA NA WA CSA 2346
    rs38064181,2
    C,F,A,H--163210617(+) ATACTG/CGCATC 2 -- ds500115Minor allele frequency- C:0.31NA EA WA CSA 738
    rs1140928321,2
    C,F--163210657(+) TTTTTT/AAAAAA 2 -- ds50011Minor allele frequency- A:0.04WA 118
    rs727121501,2
    C--163210659(+) TTTTAA/TAAAAA 2 -- ds50010--------
    rs1847756041,2
    --163210709(+) GAATGA/GATGGT 2 -- ds50010--------
    rs1380256961,2
    --163210827(+) TGCATC/TCCATT 2 -- ds50010--------
    rs1134615001,2
    C--163210902(+) AATCAA/GCGGGT 2 -- ut310--------
    rs1425158611,2
    C--163211038(+) GCATAA/GAGAGA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HDGF (156711899 - 156736717 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HDGF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv819403CNV Loss19587683
    nsv831648CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HDGF
    DNA2.0 Custom Variant and Variant Library Synthesis for HDGF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600339    OMIM disorders: --

    20/24 diseases for HDGF (see all 24):    About MalaCards
    gastrointestinal stromal tumor    keloids    chronic myeloid leukemia    ulcerative colitis
    hepatocellular carcinoma    esophageal cancer    lung adenocarcinoma    esophagitis
    nasopharyngitis    oral cancer    cholangiocarcinoma    lung cancer
    myeloid leukemia    pancreatic cancer    endotheliitis    sarcoma
    adenocarcinoma    glioblastoma    pancreatitis    melanoma


    HDGF for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for HDGF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 42.7 6 14508832 (1), 19710540 (1), 14535987 (1), 18651222 (1) (see all 6)
    nsclc 40.7 13 16397209 (4), 15310766 (3), 20043047 (2), 15870924 (2)
    tumors 27 35 15310766 (4), 19279430 (3), 20193688 (2), 14535987 (2) (see all 17)
    cancer 18.8 21 19710540 (3), 18651222 (3), 20193688 (2), 17487837 (1) (see all 9)
    colitis 16.6 2 12572860 (1)
    cancer lung 13.7 7 15870924 (3), 15310766 (1), 18478933 (1), 20193688 (1)
    colitis ulcerative 10.3 3 15086185 (2), 12572860 (1)
    metastasis 0 4 18823380 (2), 16397209 (1)
    carcinoma 0 2 16397032 (1), 17473954 (1)


    Export disorders for HDGF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HDGF gene, integrated from 9 sources (see all 112):
    (articles sorted by number of sources associating them with HDGF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hepatoma-derived growth factor binds DNA through the N-terminal PWWP domain. (PubMed id 17974029)1, 2, 9 Yang J. and Everett A.D. (2007)
    2. Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals. (PubMed id 11751870)1, 2, 9 Kishima Y.... Nakamura H. (2002)
    3. Mapping of the gene encoding the human hepatoma-derived growth factor (HDGF) with homology to the high-mobility group (HMG)-1 protein to Xq25. (PubMed id 8833162)1, 3, 9 Wanschura S....Bullerdiek J. (1996)
    4. Molecular cloning of complementary DNA for a novel human hepatoma- derived growth factor. Its homology with high mobility group-1 protein. (PubMed id 7929202)1, 2, 9 Nakamura H.... Kishimoto T. (1994)
    5. SUMOylation of the hepatoma-derived growth factor negatively influences its binding to chromatin. (PubMed id 18331345)1, 2 Thakar K.... Dietz F. (2008)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. [Expression of HDGF and its implication in stage I non-small cell lung cancer] (PubMed id 18478933)1, 9 Zhou S.J....Liu Z.D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3068 HGNC: 4856 AceView: HDGF Ensembl:ENSG00000143321 euGenes: HUgn3068
    ECgene: HDGF H-InvDB: HDGF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HDGF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HDGF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HDGF gene:
    Search GeneIP for patents involving HDGF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for HDGF (HDGF)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HDGF   OriGene RNAi products in human, mouse, rat for HDGF  
     OriGene qPCR primer pairs and template standards for HDGF   OriGene Protein Over-expression Lysate for HDGF  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HDGF  
     OriGene qSTAR qPCR primer pairs in human, mouse for HDGF   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HDGF   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HDGF   OriGene Custom Protein Services for HDGF  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HDGF
     QIAGEN SeqTarget long-range PCR primers for resequencing HDGF
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDGF
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDGF
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDGF
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDGF
     GenScript Custom Purified and Recombinant Proteins Services for HDGF GenScript cDNA clones with any tag delivered in your preferred vector for HDGF
     GenScript Custom Assay Services for HDGF GenScript Custom Superior Antibodies Services for HDGF
     GenScript Custom overexpressing Cell Line Services for HDGF CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HDGF promoter
     Search Chromatin IP Primers for HDGF
     RT2 qPCR Primer Assay in human, mouse, rat HDGF
     Search GNC Networks for HDGF
     SABiosciences PCR Arrays including human, mouse, rat HDGF
     Search Tocris compounds for HDGF
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for HDGF
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HDGF antibodies
     HDGF proteins
     HDGF lysates
     Antibodies for HDGF
     See all of Abcam's Antibodies, Kits and Proteins for HDGF
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for HDGF
     Antibodies for HDGF
     ELISAs for HDGF
     CLIAs for HDGF
     Search LifeMap BioReagents cell lines for HDGF
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDGF
     SwitchGear 3'UTR luciferase reporter plasmids for HDGF
     SwitchGear Promoter luciferase reporter plasmids for HDGF
     ThermoFisher Antibodies for HDGF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDGF
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HDGF
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HDGF
    Customized:
     lentivirus for stable overexpression of HDGF
     lentivirus expression plasmids for stable overexpression of HDGF
     adenovirus for overexpression of HDGF
     LSBio Antibodies in human, mouse, rat for HDGF
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HDGF gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4