Aliases for HDGF Gene
External Ids for HDGF Gene
Previous GeneCards Identifiers for HDGF Gene
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]
GeneCards Summary for HDGF Gene
HDGF (Hepatoma-Derived Growth Factor) is a Protein Coding gene. Diseases associated with HDGF include Lung Cancer and Hepatocellular Carcinoma. Among its related pathways are Activation of cAMP-Dependent PKA and GPCR Pathway. GO annotations related to this gene include poly(A) RNA binding and growth factor activity. An important paralog of this gene is HDGFL1.
UniProtKB/Swiss-Prot for HDGF Gene
Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor.