Aliases for HDDC3 Gene
Aliases for HDDC3 Gene
External Ids for HDDC3 Gene
- HGNC: 30522
- Entrez Gene: 374659
- Ensembl: ENSG00000184508
- UniProtKB: Q8N4P3
Previous GeneCards Identifiers for HDDC3 Gene
- GC15M089276
- GC15M091474
- GC15M067585
Summaries for HDDC3 Gene
GeneCards Summary for HDDC3 Gene
HDDC3 (HD Domain Containing 3) is a Protein Coding gene. Among its related pathways are Purine metabolism (KEGG). GO annotations related to this gene include guanosine-3,5-bis(diphosphate) 3-diphosphatase activity.
UniProtKB/Swiss-Prot for HDDC3 Gene
-
ppGpp hydrolyzing enzyme involved in starvation response.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDDC3 Gene
Genomics for HDDC3 Gene
Regulatory Elements for HDDC3 Gene
Enhancers for HDDC3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HDDC3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HDDC3 Gene
- Chromosome:
- 15
- Start:
- 90,929,964 bp from pter
- End:
- 90,932,569 bp from pter
- Size:
- 2,606 bases
- Orientation:
- Minus strand
Genomic View for HDDC3 Gene
Genes around HDDC3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q26.1 by Ensembl
- 15q26.1 by Entrez Gene
- 15q26.1 by HGNC
HDDC3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HDDC3 Gene
Proteins for HDDC3 Gene
-
Protein details for HDDC3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N4P3-MESH1_HUMAN
- Recommended name:
- Guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase MESH1
- Protein Accession:
- Q8N4P3
Protein attributes for HDDC3 Gene
- Size:
- 179 amino acids
- Molecular mass:
- 20329 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
- No Data Available
Protein Expression for HDDC3 Gene
Post-translational modifications for HDDC3 Gene
Other Protein References for HDDC3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HDDC3
- Novus Biologicals Antibodies for HDDC3
- Invitrogen Antibodies for HDDC3
- antibodies-online Antibodies for HDDC3: See all 27
- GeneTex HDDC3 antibody for HDDC3
Protein Products
-
OriGene Purified Proteins for HDDC3
- Search Origene for MassSpec and Protein Over-expression Lysates for HDDC3
- Origene Custom Protein Services for HDDC3
- Novus Biologicals proteins for HDDC3
- ProSpec Recombinant Proteins for HDDC3
- antibodies-online Proteins for HDDC3: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HDDC3
Assay Products
No data available for DME Specific Peptides for HDDC3 Gene
Domains & Families for HDDC3 Gene
Protein Domains for HDDC3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HDDC3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N4P3- Family:
-
- Belongs to the MESH1 family.
No data available for Gene Families for HDDC3 Gene
Function for HDDC3 Gene
Molecular function for HDDC3 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Guanosine 3,5-bis(diphosphate) + H(2)O = guanosine 5-diphosphate + diphosphate.
- UniProtKB/Swiss-Prot Function:
- ppGpp hydrolyzing enzyme involved in starvation response.
Enzyme Numbers (IUBMB) for HDDC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008893 | guanosine-3,5-bis(diphosphate) 3-diphosphatase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for HDDC3 Gene
- MGI mutant phenotypes for HDDC3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HDDC3:
Animal Models for HDDC3 Gene
- MGI Knock Outs for HDDC3:
-
- Hddc3 tm1.1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HDDC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HDDC3 gene
- Search ViGene Biosciences for HDDC3
CRISPR Products
-
OriGene CRISPR knockouts for HDDC3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HDDC3
- GenScript: Design CRISPR guide RNA sequences for HDDC3
miRNA for HDDC3 Gene
- miRTarBase miRNAs that target HDDC3
miRNA Products
- Search ViGene Biosciences for HDDC3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HDDC3
- Browse OriGene Inhibitory RNA Products For HDDC3
-
ViGene Biosciences ready-to-package AAV shRNAs for HDDC3 gene
Clone Products
- Sino Biological Human cDNA Clone for HDDC3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HDDC3
-
ViGene Biosciences adenoviral particle packaged cDNA for HDDC3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HDDC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HDDC3 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HDDC3 Gene
Localization for HDDC3 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 3 |
| mitochondrion | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HDDC3 Gene
Pathways & Interactions for HDDC3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Purine metabolism (KEGG) | ||
Pathways by source for HDDC3 Gene
1 KEGG pathway for HDDC3 Gene
Interacting Proteins for HDDC3 Gene
Selected Interacting proteins:
ENSP00000330721
Q8N4P3-MESH1_HUMAN
for HDDC3 Gene via
STRING
IID
UniProtKB
No data available for SIGNOR curated interactions for HDDC3 Gene
Drugs & Compounds for HDDC3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Guanosine 3',5'-bis(diphosphate) |
|
|
||||
| pyrophosphate |
|
14000-31-8 |
|
Transcripts for HDDC3 Gene
mRNA/cDNA for HDDC3 Gene
- (2) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (92) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HDDC3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HDDC3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HDDC3
- GenScript: Design CRISPR guide RNA sequences for HDDC3
miRNA Products
- Search ViGene Biosciences for HDDC3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HDDC3
- Browse OriGene Inhibitory RNA Products For HDDC3
-
ViGene Biosciences ready-to-package AAV shRNAs for HDDC3 gene
Clone Products
- Sino Biological Human cDNA Clone for HDDC3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HDDC3 Gene
This gene is overexpressed in Skin (12.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HDDC3 Gene
NURSA nuclear receptor signaling pathways regulating expression of HDDC3 Gene:
HDDC3SOURCE GeneReport for Unigene cluster for HDDC3 Gene:
Hs.349979Primer Products
-
OriGene qPCR primer pairs for HDDC3
-
OriGene qPCR primer pairs and template standards for HDDC3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDDC3 Gene
Orthologs for HDDC3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HDDC3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HDDC3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HDDC3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hddc3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hddc3 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HDDC3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HDDC3 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HDDC3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hddc3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hddc3 34 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10177 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012646 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Mesh1 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | ZK909.3 34 35 |
|
- Species where no ortholog for HDDC3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HDDC3 Gene
No data available for Paralogs for HDDC3 Gene
Variants for HDDC3 Gene
| SNP ID | Clin | Chr 15 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1001590636 | -- | 90,930,458(+) | CTCCC(A/G)GGTTC | intron-variant | |
| rs1002812608 | -- | 90,932,598(+) | CAGCG(-/C)CCCCT | intron-variant, upstream-variant-2KB | |
| rs1002885222 | -- | 90,931,142(+) | AAAAA(A/T)GCAAG | intron-variant, nc-transcript-variant, utr-variant-3-prime | |
| rs1003083414 | -- | 90,933,276(+) | TGTGG(A/G)CCCCT | intron-variant, upstream-variant-2KB | |
| rs1004029773 | -- | 90,932,900(+) | GAGCG(G/T)GAAGA | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.52;
29.53% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HDDC3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDDC3 Gene
Disorders for HDDC3 Gene
Relevant External Links for HDDC3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HDDC3
No disorders were found for HDDC3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDDC3 Gene
Publications for HDDC3 Gene
- A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. (PMID: 20818390) Sun D. … Chung J. (Nat. Struct. Mol. Biol. 2010) 3 4 64
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
Products for HDDC3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HDDC3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HDDC3
- Search Origene for MassSpec and Protein Over-expression Lysates for HDDC3
- Origene Custom Protein Services for HDDC3
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HDDC3
- Browse OriGene Inhibitory RNA Products For HDDC3
- OriGene qPCR primer pairs and template standards for HDDC3
- OriGene qPCR primer pairs for HDDC3
- OriGene CRISPR knockouts for HDDC3
- OriGene ORF clones in human for HDDC3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HDDC3
- GenScript: Next-day shipping cDNA ORF clone for HDDC3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HDDC3
- GenScript Custom Assay Services for HDDC3
- GenScript Custom overexpressing Cell Line Services for HDDC3
- GenScript: Design CRISPR guide RNA sequences for HDDC3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HDDC3
- Sino Biological Human cDNA Clone for HDDC3
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HDDC3
- Novus Biologicals proteins for HDDC3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for HDDC3
- antibodies-online Antibodies for HDDC3: See all 27
- Search antibodies-online for kits
- antibodies-online Proteins for HDDC3: See all 6
- Search antibodies-online for peptides
- GeneTex HDDC3 antibody for HDDC3
- Search GeneTex for Proteins for HDDC3
- ViGene Biosciences adenoviral particle packaged cDNA for HDDC3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HDDC3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HDDC3 gene
- Search ViGene Biosciences for HDDC3
- Horizon Cell Lines for HDDC3
- Cyagen custom Knockout/knockin (KOKI) mouse models for HDDC3
- VectorBuilder custom plasmid, inducible vectors for HDDC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HDDC3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HDDC3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer