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Aliases for HDDC3 Gene

Aliases for HDDC3 Gene

  • HD Domain Containing 3 2 3 5
  • Penta-Phosphate Guanosine-3-Pyrophosphohydrolase 3 4
  • HD Domain-Containing Protein 3 3 4
  • Metazoan SpoT Homolog 1 3 4
  • (PpGpp)Ase 3 4
  • MESH1 3 4
  • EC 3.1.7.2 4

External Ids for HDDC3 Gene

Previous GeneCards Identifiers for HDDC3 Gene

  • GC15M089276
  • GC15M091474
  • GC15M067585

Summaries for HDDC3 Gene

GeneCards Summary for HDDC3 Gene

HDDC3 (HD Domain Containing 3) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG). GO annotations related to this gene include guanosine-3,5-bis(diphosphate) 3-diphosphatase activity.

UniProtKB/Swiss-Prot for HDDC3 Gene

  • ppGpp hydrolyzing enzyme involved in starvation response.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDDC3 Gene

Genomics for HDDC3 Gene

Regulatory Elements for HDDC3 Gene

Enhancers for HDDC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HDDC3 on UCSC Golden Path with GeneCards custom track

Promoters for HDDC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HDDC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HDDC3 Gene

Chromosome:
15
Start:
90,929,964 bp from pter
End:
90,932,569 bp from pter
Size:
2,606 bases
Orientation:
Minus strand

Genomic View for HDDC3 Gene

Genes around HDDC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDDC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDDC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDDC3 Gene

Proteins for HDDC3 Gene

  • Protein details for HDDC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4P3-MESH1_HUMAN
    Recommended name:
    Guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase MESH1
    Protein Accession:
    Q8N4P3

    Protein attributes for HDDC3 Gene

    Size:
    179 amino acids
    Molecular mass:
    20329 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HDDC3 Gene

    Alternative splice isoforms for HDDC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDDC3 Gene

Proteomics data for HDDC3 Gene at MOPED

Post-translational modifications for HDDC3 Gene

  • Ubiquitination at Lys 123
  • Modification sites at PhosphoSitePlus

Other Protein References for HDDC3 Gene

No data available for DME Specific Peptides for HDDC3 Gene

Domains & Families for HDDC3 Gene

Protein Domains for HDDC3 Gene

Suggested Antigen Peptide Sequences for HDDC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4P3

UniProtKB/Swiss-Prot:

MESH1_HUMAN :
  • Contains 1 HD domain.
  • Belongs to the MESH1 family.
Domain:
  • Contains 1 HD domain.
Family:
  • Belongs to the MESH1 family.
genes like me logo Genes that share domains with HDDC3: view

No data available for Gene Families for HDDC3 Gene

Function for HDDC3 Gene

Molecular function for HDDC3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Guanosine 3,5-bis(diphosphate) + H(2)O = guanosine 5-diphosphate + diphosphate.
UniProtKB/Swiss-Prot Function:
ppGpp hydrolyzing enzyme involved in starvation response.

Enzyme Numbers (IUBMB) for HDDC3 Gene

Gene Ontology (GO) - Molecular Function for HDDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008728 GTP diphosphokinase activity IBA --
GO:0008893 guanosine-3,5-bis(diphosphate) 3-diphosphatase activity IBA --
genes like me logo Genes that share ontologies with HDDC3: view
genes like me logo Genes that share phenotypes with HDDC3: view

Animal Model Products

miRNA for HDDC3 Gene

miRTarBase miRNAs that target HDDC3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HDDC3 Gene

Localization for HDDC3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HDDC3 Gene COMPARTMENTS Subcellular localization image for HDDC3 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HDDC3 Gene

Pathways & Interactions for HDDC3 Gene

SuperPathways for HDDC3 Gene

Superpath Contained pathways
1 Pyrimidine metabolism (KEGG)
genes like me logo Genes that share pathways with HDDC3: view

Pathways by source for HDDC3 Gene

1 KEGG pathway for HDDC3 Gene

Gene Ontology (GO) - Biological Process for HDDC3 Gene

None

No data available for SIGNOR curated interactions for HDDC3 Gene

Drugs & Compounds for HDDC3 Gene

(2) Drugs for HDDC3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphosphate Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0

(2) Additional Compounds for HDDC3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Guanosine 3',5'-bis(diphosphate)
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with HDDC3: view

Transcripts for HDDC3 Gene

Unigene Clusters for HDDC3 Gene

HD domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HDDC3 Gene

No ASD Table

Relevant External Links for HDDC3 Gene

GeneLoc Exon Structure for
HDDC3
ECgene alternative splicing isoforms for
HDDC3

Expression for HDDC3 Gene

mRNA expression in normal human tissues for HDDC3 Gene

Protein differential expression in normal tissues from HIPED for HDDC3 Gene

This gene is overexpressed in Skin (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HDDC3 Gene



SOURCE GeneReport for Unigene cluster for HDDC3 Gene Hs.349979

genes like me logo Genes that share expression patterns with HDDC3: view

Protein tissue co-expression partners for HDDC3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HDDC3 Gene

Orthologs for HDDC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HDDC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HDDC3 35
  • 91.99 (n)
  • 93.85 (a)
HDDC3 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HDDC3 35
  • 91.06 (n)
  • 93.85 (a)
HDDC3 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hddc3 35
  • 87.71 (n)
  • 95.53 (a)
Hddc3 16
Hddc3 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HDDC3 35
  • 99.44 (n)
  • 98.88 (a)
HDDC3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hddc3 35
  • 86.78 (n)
  • 94.97 (a)
oppossum
(Monodelphis domestica)
Mammalia HDDC3 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves HDDC3 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HDDC3 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hddc3 35
  • 68.9 (n)
  • 74.86 (a)
zebrafish
(Danio rerio)
Actinopterygii hddc3 35
  • 66.29 (n)
  • 72.88 (a)
hddc3 36
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10177 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012646 35
  • 62.59 (n)
  • 70.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mesh1 35
  • 59.92 (n)
  • 59.54 (a)
Mesh1 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK909.3 35
  • 57.92 (n)
  • 58.75 (a)
ZK909.3 36
  • 34 (a)
OneToOne
Species with no ortholog for HDDC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDDC3 Gene

ENSEMBL:
Gene Tree for HDDC3 (if available)
TreeFam:
Gene Tree for HDDC3 (if available)

Paralogs for HDDC3 Gene

No data available for Paralogs for HDDC3 Gene

Variants for HDDC3 Gene

Structural Variations from Database of Genomic Variants (DGV) for HDDC3 Gene

Variant ID Type Subtype PubMed ID
nsv833089 CNV Loss 17160897
nsv515661 CNV Loss 19592680
nsv833090 CNV Loss 17160897

Variation tolerance for HDDC3 Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HDDC3 Gene

HapMap Linkage Disequilibrium report
HDDC3
Human Gene Mutation Database (HGMD)
HDDC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HDDC3 Gene

Disorders for HDDC3 Gene

Relevant External Links for HDDC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HDDC3

No disorders were found for HDDC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDDC3 Gene

Publications for HDDC3 Gene

  1. A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. (PMID: 20818390) Sun D. … Chung J. (Nat. Struct. Mol. Biol. 2010) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for HDDC3 Gene

Sources for HDDC3 Gene

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