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Aliases for HDDC2 Gene

Aliases for HDDC2 Gene

  • HD Domain Containing 2 2 3
  • Hepatitis C Virus NS5A-Transactivated Protein 2 3 4
  • HCV NS5A-Transactivated Protein 2 3 4
  • C6orf74 3 4
  • NS5ATP2 3 4
  • Chromosome 6 Open Reading Frame 74 2
  • HD Domain-Containing Protein 2 3
  • DJ167O5.2 3
  • CGI-130 3

External Ids for HDDC2 Gene

Previous Symbols for HDDC2 Gene

  • C6orf74

Summaries for HDDC2 Gene

GeneCards Summary for HDDC2 Gene

HDDC2 (HD Domain Containing 2) is a Protein Coding gene. Diseases associated with HDDC2 include hepatitis c and hepatitis c virus. GO annotations related to this gene include phosphoric diester hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDDC2 Gene

Genomics for HDDC2 Gene

Genomic Location for HDDC2 Gene

Start:
125,219,962 bp from pter
End:
125,302,141 bp from pter
Size:
82,180 bases
Orientation:
Minus strand

Genomic View for HDDC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HDDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDDC2 Gene

Regulatory Elements for HDDC2 Gene

Proteins for HDDC2 Gene

  • Protein details for HDDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4H3-HDDC2_HUMAN
    Recommended name:
    HD domain-containing protein 2
    Protein Accession:
    Q7Z4H3
    Secondary Accessions:
    • Q5TDQ4
    • Q6NZ49
    • Q9BTT2
    • Q9BV31
    • Q9Y3D1

    Protein attributes for HDDC2 Gene

    Size:
    204 amino acids
    Molecular mass:
    23390 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34125.1; Type=Miscellaneous discrepancy; Note=Correction of a non-canonical splice junction.; Evidence={ECO:0000305}; Sequence=AAH03357.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HDDC2 Gene

    Alternative splice isoforms for HDDC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDDC2 Gene

Proteomics data for HDDC2 Gene at MOPED

Post-translational modifications for HDDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HDDC2 Gene

No data available for DME Specific Peptides for HDDC2 Gene

Domains for HDDC2 Gene

Protein Domains for HDDC2 Gene

UniProtKB/Swiss-Prot:

HDDC2_HUMAN
Domain:
  • Contains 1 HD domain.:
    • Q7Z4H3
Family:
  • Belongs to the HDDC2 family.:
    • Q7Z4H3
genes like me logo Genes that share domains with HDDC2: view

No data available for Gene Families for HDDC2 Gene

Function for HDDC2 Gene

Gene Ontology (GO) - Molecular Function for HDDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
genes like me logo Genes that share ontologies with HDDC2: view

miRNA for HDDC2 Gene

miRTarBase miRNAs that target HDDC2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HDDC2 Gene

Localization for HDDC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HDDC2 Gene COMPARTMENTS Subcellular localization image for HDDC2 gene
Compartment Confidence
mitochondrion 3
peroxisome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HDDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HDDC2: view

Pathways for HDDC2 Gene

SuperPathways for HDDC2 Gene

No Data Available

Interacting Proteins for HDDC2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381220%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000381220 Q7Z4H3-HDDC2_HUMAN for HDDC2 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for HDDC2 Gene

None

No data available for Pathways by source for HDDC2 Gene

Transcripts for HDDC2 Gene

mRNA/cDNA for HDDC2 Gene

Unigene Clusters for HDDC2 Gene

HD domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HDDC2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - - - - - -
SP10: - -
SP11: - -
SP12: -

Relevant External Links for HDDC2 Gene

GeneLoc Exon Structure for
HDDC2
ECgene alternative splicing isoforms for
HDDC2

Expression for HDDC2 Gene

mRNA expression in normal human tissues for HDDC2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HDDC2 Gene

SOURCE GeneReport for Unigene cluster for HDDC2 Gene Hs.32826

genes like me logo Genes that share expressions with HDDC2: view

Orthologs for HDDC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HDDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDDC2 36
  • 99.18 (n)
  • 99.02 (a)
HDDC2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HDDC2 36
  • 91.01 (n)
  • 90.2 (a)
HDDC2 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HDDC2 36
  • 86.93 (n)
  • 89.2 (a)
HDDC2 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hddc2 36
  • 85.4 (n)
  • 89.69 (a)
Hddc2 16
Hddc2 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HDDC2 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HDDC2 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hddc2 36
  • 83.58 (n)
  • 86.43 (a)
chicken
(Gallus gallus)
Aves HDDC2 36
  • 74.91 (n)
  • 78.35 (a)
HDDC2 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HDDC2 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23921 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hddc2 36
  • 69.05 (n)
  • 74.49 (a)
Str.10992 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14203 36
zebrafish
(Danio rerio)
Actinopterygii hddc2 36
  • 64.13 (n)
  • 67.93 (a)
hddc2 37
  • 63 (a)
OneToOne
wufb71h08 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012582 36
  • 50.45 (n)
  • 41.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11050 36
  • 48.85 (n)
  • 42.86 (a)
CG11050 37
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F45F2.9 36
  • 49.53 (n)
  • 39.66 (a)
F45F2.9 37
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL036C 36
  • 50.67 (n)
  • 40.57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 34 (a)
OneToMany
-- 37
  • 33 (a)
OneToMany
-- 39
YBR242W 36
  • 51.02 (n)
  • 44.13 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06798g 36
  • 45.93 (n)
  • 38.95 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G23820 36
  • 59.3 (n)
  • 52.33 (a)
rice
(Oryza sativa)
Liliopsida Os02g0179100 36
  • 53.56 (n)
  • 51.45 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04470 36
  • 46.71 (n)
  • 38.82 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC4G3.17 36
  • 52.85 (n)
  • 48.07 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 60 (a)
OneToOne
Species with no ortholog for HDDC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDDC2 Gene

ENSEMBL:
Gene Tree for HDDC2 (if available)
TreeFam:
Gene Tree for HDDC2 (if available)

Paralogs for HDDC2 Gene

No data available for Paralogs for HDDC2 Gene

Variants for HDDC2 Gene

Sequence variations from dbSNP and Humsavar for HDDC2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs14750 -- 125,276,095(+) ACAAT(A/G)AAATG utr-variant-3-prime, nc-transcript-variant
rs987166 -- 125,299,298(+) GAATC(A/G)TTTGA intron-variant
rs987167 -- 125,299,433(+) CATGT(C/G)AATCA intron-variant
rs987168 -- 125,299,732(+) CTGAG(C/T)AACAG intron-variant
rs1040803 -- 125,275,811(+) ATGAA(C/T)CTAGC utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HDDC2 Gene

Variant ID Type Subtype PubMed ID
nsv886625 CNV Gain 21882294
nsv886626 CNV Gain 21882294
nsv886635 CNV Loss 21882294
nsv820070 CNV Gain 19587683

Relevant External Links for HDDC2 Gene

HapMap Linkage Disequilibrium report
HDDC2

Disorders for HDDC2 Gene

Relevant External Links for HDDC2

Genetic Association Database (GAD)
HDDC2
Human Genome Epidemiology (HuGE) Navigator
HDDC2
genes like me logo Genes that share disorders with HDDC2: view

No data available for UniProtKB/Swiss-Prot for HDDC2 Gene

Publications for HDDC2 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for HDDC2 Gene

Sources for HDDC2 Gene

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