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Aliases for HDDC2 Gene

Aliases for HDDC2 Gene

  • HD Domain Containing 2 2 3 5
  • Hepatitis C Virus NS5A-Transactivated Protein 2 3 4
  • HCV NS5A-Transactivated Protein 2 3 4
  • C6orf74 3 4
  • NS5ATP2 3 4
  • Chromosome 6 Open Reading Frame 74 2
  • Testicular Tissue Protein Li 83 3
  • HD Domain-Containing Protein 2 3
  • DJ167O5.2 3
  • CGI-130 3

External Ids for HDDC2 Gene

Previous HGNC Symbols for HDDC2 Gene

  • C6orf74

Previous GeneCards Identifiers for HDDC2 Gene

  • GC06M125639
  • GC06M123173
  • GC06M125596

Summaries for HDDC2 Gene

GeneCards Summary for HDDC2 Gene

HDDC2 (HD Domain Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDDC2 Gene

Genomics for HDDC2 Gene

Regulatory Elements for HDDC2 Gene

Enhancers for HDDC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G125299 1.5 FANTOM5 ENCODE 32.3 +0.5 506 4.7 HDGF HNRNPUL1 PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 HDDC2 LOC100126584
GH06G125200 1.3 Ensembl ENCODE 21.4 +100.2 100189 2.8 HDGF SIN3A ZNF2 YY1 ZNF766 FOS REST ZNF592 SMARCA4 NBN HDDC2 TPD52L1 LOC100126584
GH06G125203 1.1 Ensembl ENCODE 24.5 +98.5 98488 0.3 TBP CBX3 NFRKB SMAD5 USF2 ELF1 ZNF592 CREB3 TFDP1 RAD51 HDDC2 LOC100126584
GH06G125153 1.1 ENCODE 20.8 +147.8 147771 2.4 HDGF CREB3L1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143 FOS HDDC2 TPD52L1 LOC100126584
GH06G125187 1 Ensembl ENCODE 16.3 +113.5 113517 1.7 HDAC1 CTCF ATF1 GTF2E2 BACH1 RAD21 FOSL1 ZNF766 ZNF316 GATA2 HDDC2 LOC100126584 TPD52L1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HDDC2 on UCSC Golden Path with GeneCards custom track

Promoters for HDDC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000202209 541 1601 HDGF HNRNPUL1 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF207

Genomic Location for HDDC2 Gene

Chromosome:
6
Start:
125,219,962 bp from pter
End:
125,302,141 bp from pter
Size:
82,180 bases
Orientation:
Minus strand

Genomic View for HDDC2 Gene

Genes around HDDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDDC2 Gene

Proteins for HDDC2 Gene

  • Protein details for HDDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4H3-HDDC2_HUMAN
    Recommended name:
    HD domain-containing protein 2
    Protein Accession:
    Q7Z4H3
    Secondary Accessions:
    • Q5TDQ4
    • Q6NZ49
    • Q9BTT2
    • Q9BV31
    • Q9Y3D1

    Protein attributes for HDDC2 Gene

    Size:
    204 amino acids
    Molecular mass:
    23390 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34125.1; Type=Miscellaneous discrepancy; Note=Correction of a non-canonical splice junction.; Evidence={ECO:0000305}; Sequence=AAH03357.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HDDC2 Gene

    Alternative splice isoforms for HDDC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDDC2 Gene

Post-translational modifications for HDDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HDDC2 Gene

No data available for DME Specific Peptides for HDDC2 Gene

Domains & Families for HDDC2 Gene

Protein Domains for HDDC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4H3

UniProtKB/Swiss-Prot:

HDDC2_HUMAN :
  • Belongs to the HDDC2 family.
Family:
  • Belongs to the HDDC2 family.
genes like me logo Genes that share domains with HDDC2: view

No data available for Gene Families for HDDC2 Gene

Function for HDDC2 Gene

Gene Ontology (GO) - Molecular Function for HDDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
genes like me logo Genes that share ontologies with HDDC2: view
genes like me logo Genes that share phenotypes with HDDC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HDDC2 Gene

Localization for HDDC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDDC2 gene
Compartment Confidence
extracellular 5
mitochondrion 4
peroxisome 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for HDDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HDDC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HDDC2 Gene

Pathways & Interactions for HDDC2 Gene

SuperPathways for HDDC2 Gene

No Data Available

Interacting Proteins for HDDC2 Gene

Gene Ontology (GO) - Biological Process for HDDC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HDDC2 Gene

Drugs & Compounds for HDDC2 Gene

No Compound Related Data Available

Transcripts for HDDC2 Gene

Unigene Clusters for HDDC2 Gene

HD domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDDC2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - - - - - -
SP10: - -
SP11: - -
SP12: -

Relevant External Links for HDDC2 Gene

GeneLoc Exon Structure for
HDDC2
ECgene alternative splicing isoforms for
HDDC2

Expression for HDDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HDDC2 Gene

Protein differential expression in normal tissues from HIPED for HDDC2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1) and Skin (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HDDC2 Gene



Protein tissue co-expression partners for HDDC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HDDC2 Gene:

HDDC2

SOURCE GeneReport for Unigene cluster for HDDC2 Gene:

Hs.32826

Evidence on tissue expression from TISSUES for HDDC2 Gene

  • Nervous system(4.5)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with HDDC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDDC2 Gene

Orthologs for HDDC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HDDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDDC2 34 35
  • 99.18 (n)
cow
(Bos Taurus)
Mammalia HDDC2 34 35
  • 91.01 (n)
dog
(Canis familiaris)
Mammalia HDDC2 34 35
  • 86.93 (n)
mouse
(Mus musculus)
Mammalia Hddc2 16 35 34
  • 85.4 (n)
rat
(Rattus norvegicus)
Mammalia Hddc2 34
  • 83.58 (n)
oppossum
(Monodelphis domestica)
Mammalia HDDC2 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HDDC2 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves HDDC2 35 34
  • 74.91 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HDDC2 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hddc2 34
  • 69.05 (n)
Str.10992 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23921 34
zebrafish
(Danio rerio)
Actinopterygii hddc2 34 35
  • 64.13 (n)
wufb71h08 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14203 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012582 34
  • 50.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11050 34 35
  • 48.85 (n)
worm
(Caenorhabditis elegans)
Secernentea F45F2.9 34 35
  • 49.53 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YBR242W 34
  • 51.02 (n)
-- 35
  • 34 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
-- 37
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL036C 34
  • 50.67 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06798g 34
  • 45.93 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G23820 34
  • 59.3 (n)
rice
(Oryza sativa)
Liliopsida Os02g0179100 34
  • 53.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 60 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC4G3.17 34
  • 52.85 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04470 34
  • 46.71 (n)
Species where no ortholog for HDDC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDDC2 Gene

ENSEMBL:
Gene Tree for HDDC2 (if available)
TreeFam:
Gene Tree for HDDC2 (if available)

Paralogs for HDDC2 Gene

No data available for Paralogs for HDDC2 Gene

Variants for HDDC2 Gene

Sequence variations from dbSNP and Humsavar for HDDC2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000135485 -- 125,288,666(+) GTGGG(C/T)GAAGG intron-variant
rs1000177464 -- 125,295,010(+) ATAGC(A/G)TTTTT intron-variant
rs1000356610 -- 125,292,112(+) TGAGA(C/G)TGGGA intron-variant
rs1000424650 -- 125,285,582(+) CAGAA(A/G)AGTCC intron-variant
rs1000437611 -- 125,282,688(+) AATGG(A/G)CTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDDC2 Gene

Variant ID Type Subtype PubMed ID
nsv604601 CNV loss 21841781
nsv820070 CNV gain 19587683

Variation tolerance for HDDC2 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HDDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HDDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDDC2 Gene

Disorders for HDDC2 Gene

Relevant External Links for HDDC2

Genetic Association Database (GAD)
HDDC2
Human Genome Epidemiology (HuGE) Navigator
HDDC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HDDC2

No disorders were found for HDDC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDDC2 Gene

Publications for HDDC2 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for HDDC2 Gene

Sources for HDDC2 Gene

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