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HDDC2 Gene

protein-coding   GIFtS: 50
GCID: GC06M125596

HD Domain Containing 2

(Previous name: chromosome 6 open reading frame 74)
(Previous symbol: C6orf74)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HD Domain Containing 21 2     HCV NS5A-Transactivated Protein 22 3
C6orf741 2 3     Chromosome 6 Open Reading Frame 741
Hepatitis C Virus NS5A-Transactivated Protein 22 3     dJ167O5.22
NS5ATP22 3     HD Domain-Containing Protein 22

External Ids:    HGNC: 210781   Entrez Gene: 510202   Ensembl: ENSG000001119067   UniProtKB: Q7Z4H33   

Export aliases for HDDC2 gene to outside databases

Previous GC identifers: GC06M125639 GC06M123173


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HDDC2 Gene:
HDDC2 (HD domain containing 2) is a protein-coding gene. Diseases associated with HDDC2 include hepatitis c, and hepatitis c virus. GO annotations related to this gene include phosphoric diester hydrolase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HDDC2 gene promoter:
         SRF   SRF (504 AA)   FOXD1   Cdc5   Meis-1b   RORalpha2   Meis-1a   LyF-1   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HDDC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HDDC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13-q24.3   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q13-q24.3

HDDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDDC2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M125596:  view genomic region     (about GC identifiers)

Start:
125,541,108 bp from pter      End:
125,623,282 bp from pter
Size:
82,175 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HDDC2_HUMAN, Q7Z4H3 (See protein sequence)
Recommended Name: HD domain-containing protein 2  
Size: 204 amino acids; 23390 Da
Sequence caution: Sequence=AAD34125.1; Type=Miscellaneous discrepancy; Note=Correction of a non-canonical splice
junction; Sequence=AAH03357.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for HDDC2:
4DMB (3D)        4L1J (3D)        4L7E (3D)        4L7W (3D)    
Secondary accessions: Q5TDQ4 Q6NZ49 Q9BTT2 Q9BV31 Q9Y3D1
Alternative splicing: 3 isoforms:  Q7Z4H3-1   Q7Z4H3-2   Q7Z4H3-3   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for HDDC2: NX_Q7Z4H3

Explore proteomics data for HDDC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HDDC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057147.2  
    ENSEMBL proteins: 
     ENSP00000476969   ENSP00000316242   ENSP00000477277   ENSP00000381220   ENSP00000477042  
     ENSP00000357361  

    HDDC2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for HDDC2
    OriGene Protein Over-expression Lysate for HDDC2
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    Novus Biologicals HDDC2 Protein
    Novus Biologicals HDDC2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HDDC2

    HDDC2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals HDDC2 Antibody
    Abcam antibodies for HDDC2
    Cloud-Clone Corp. Antibodies for HDDC2
    ThermoFisher Antibody for HDDC2
    LSBio Antibodies in human, mouse, rat for HDDC2

    HDDC2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HDDC2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HDDC2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HDDC2
    Cloud-Clone Corp. CLIAs for HDDC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR006674 HD_domain
     IPR003607 HD/PDEase_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z4H3

    ProtoNet protein and cluster: Q7Z4H3

    1 Blocks protein domain: IPB006674 Metal-dependent phosphohydrolase

    UniProtKB/Swiss-Prot: HDDC2_HUMAN, Q7Z4H3
    Similarity: Belongs to the HDDC2 family
    Similarity: Contains 1 HD domain


    HDDC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005515protein binding IPI--
    GO:0008081phosphoric diester hydrolase activity IEA--
    GO:0046872metal ion binding IEA--
         
    HDDC2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HDDC2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HDDC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HDDC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HDDC2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HDDC2:
    hsa-mir-93-5p (MIRT048783), hsa-mir-877-3p (MIRT036945)

    Block miRNA regulation of human, mouse, rat HDDC2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate HDDC2:
    hsa-miR-149 hsa-miR-185 hsa-miR-1324 hsa-miR-4306 hsa-miR-551b* hsa-miR-103a-2* hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidHDDC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HDDC2
    Predesigned siRNA for gene silencing in human, mouse, rat HDDC2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HDDC2

    Clone
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    OriGene clones in human, mouse for HDDC2 (see all 8)
    OriGene ORF clones in mouse, rat for HDDC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HDDC2 (NM_016063)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDDC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDDC2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HDDC2
    Browse ESI BIO Cell Lines and PureStem Progenitors for HDDC2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDDC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    peroxisome2
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    HDDC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HDDC2
    Interactions:

        Search GeneGlobe Interaction Network for HDDC2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for HDDC2 (Q7Z4H31, 3 ENSP000003812204) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WDR12Q9GZL73, ENSP000002610154I2D: score=3 STRING: ENSP00000261015
    CHMP2AO436333I2D: score=5 
    ATG101Q9BSB43I2D: score=1 
    BOP1Q141373I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HDDC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HDDC2 gene: 
    NM_016063.2  

    Unigene Cluster for HDDC2:

    HD domain containing 2
    Hs.32826  [show with all ESTs]
    Unigene Representative Sequence: AK128067
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000608456 ENST00000609477 ENST00000318787 ENST00000608295 ENST00000609021
    ENST00000398153(uc003qaa.1) ENST00000608461 ENST00000608532 ENST00000608284
    ENST00000609574 ENST00000368377(uc003qab.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HDDC2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate HDDC2:
    hsa-miR-149 hsa-miR-185 hsa-miR-1324 hsa-miR-4306 hsa-miR-551b* hsa-miR-103a-2* hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidHDDC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HDDC2
    Predesigned siRNA for gene silencing in human, mouse, rat HDDC2
    Clone
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    OriGene clones in human, mouse for HDDC2 (see all 8)
    OriGene ORF clones in mouse, rat for HDDC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HDDC2 (NM_016063)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDDC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDDC2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HDDC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HDDC2
      QuantiTect SYBR Green Assays in human, mouse, rat HDDC2
      QuantiFast Probe-based Assays in human, mouse, rat HDDC2

    Additional mRNA sequence: 

    AF151888.1 AF529363.1 AK128067.1 BC001671.2 BC003357.1 BC061520.1 BC066332.1 

    12 DOTS entries:

    DT.92439299  DT.101984240  DT.86853114  DT.100818402  DT.100818399  DT.92439291  DT.95183747  DT.421178 
    DT.121377160  DT.97820709  DT.92439290  DT.97859897 

    Selected AceView cDNA sequences (see all 255):

    AA962145 BC061520 BE897396 BG032061 AA373842 CR595765 BM828335 AI335751 
    AA327589 W73305 BC001671 BQ574974 BE502119 CB161177 CA437612 BU681940 
    AK128067 BQ671076 BM713430 BM727533 CD367692 BQ020758 BE383845 BG319451 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HDDC2 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f
    SP1:        -     -     -     -                 -           -     -           -     -           -     -                                       
    SP2:                          -                 -           -     -           -     -           -     -                                       
    SP3:                                            -           -     -           -     -           -     -                                       
    SP4:        -     -     -     -                 -     -     -     -           -     -           -     -                                       
    SP5:                          -                 -     -     -     -           -     -           -     -                                       


    ECgene alternative splicing isoforms for HDDC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HDDC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGAACACT
    HDDC2 Expression
    About this image

    HDDC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HDDC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.32826
        Custom PCR Arrays for HDDC2
    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDDC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HDDC2 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hddc21 , 5 HD domain containing 21, 5 85.4(n)1
    89.69(a)1
      10 (17.34 cM)5
    696921  NM_027168.21  NP_081444.11 
     313133825 
    chicken
    (Gallus gallus)
    Aves HDDC21 HD domain containing 2 74.91(n)
    78.35(a)
      421719  NM_001277918.1  NP_001264847.1 
    lizard
    (Anolis carolinensis)
    Reptilia HDDC26
    HD domain containing 2
    81(a)
    1 ↔ 1
    1(180738607-180752671)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.239212 Xenopus laevis transcribed sequence with weak similarity more 77.21(n)    CB198244.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb71h082 wufb71h08 73.72(n)   322725  CK355860.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG110501 CG11050 48.85(n)
    42.86(a)
      33924  NM_135208.5  NP_609052.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F45F2.91 F45F2.9 49.53(n)
    39.66(a)
      185809  NM_001269169.1  NP_001256098.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YBR242W)4
    YBR242W1
    Putative protein of unknown function; green fluorescent more4
    YBR242W1
    51.02(n)1
    44.13(a)1
      2(704670-705386)4
    8525441, 4  NP_009801.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G238201 AT2G23820 59.3(n)
    52.33(a)
      816914  NM_201793.3  NP_973522.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01791001 Os02g0179100 53.56(n)
    51.45(a)
      4328498  NM_001052616.1  NP_001046081.1 


    ENSEMBL Gene Tree for HDDC2 (if available)
    TreeFam Gene Tree for HDDC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HDDC2 (see all 639)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1416896691,2
    --125596189(+) TAACCA/GTATAT 1 -- ds50010--------
    rs1863604411,2
    C--125596367(+) GCCTCA/GAAGGC 1 -- ds50010--------
    rs779564101,2
    C,F--125596478(+) TTCAAT/AGTAAA 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1921048021,2
    --125596570(+) AATGAC/TCCCAG 1 -- ut310--------
    rs1834752961,2
    --125596609(+) ACATGC/TTTTTA 1 -- ut310--------
    rs94913521,2
    C,F,A,H--125596750(+) GTAGGT/ATTACA 1 -- ut3124Minor allele frequency- A:0.23NA NS EA WA CSA 2650
    rs10408031,2
    C,F,A,H--125596957(+) ATGAAT/CCTAGC 1 -- ut31 ese326Minor allele frequency- C:0.27MN NA NS EA WA CSA 2664
    rs94913531,2
    C,A,H--125597023(+) TATTCT/CAATAT 1 -- ut316Minor allele frequency- C:0.27WA CSA NA EA 363
    rs737724171,2
    C,F--125597103(+) ACTTTC/TATGAC 1 -- ut313Minor allele frequency- T:0.13WA CSA 122
    rs1175226581,2
    C,F--125597150(+) TGTATC/TACATT 1 -- ut311Minor allele frequency- T:0.04EA 120

    HapMap Linkage Disequilibrium report for HDDC2 (125541108 - 125623282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HDDC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv886635CNV Loss21882294
    nsv820070CNV Gain19587683
    nsv886626CNV Gain21882294
    nsv886625CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HDDC2
    DNA2.0 Custom Variant and Variant Library Synthesis for HDDC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for HDDC2:    
    About MalaCards
    hepatitis c    hepatitis c virus    hepatitis    malaria


    HDDC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HDDC2
    Human Genome Epidemiology (HuGE) Navigator: HDDC2 (1 document)

    Export disorders for HDDC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HDDC2 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with HDDC2)
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    world of online information

    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    7. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)
    8. Cloning and identification of NS5ATP2 gene and its spliced variant transactivated by hepatitis C virus non-structural protein 5A. (PubMed id 15188496)2 Yang Q.... Zhang S.-L. (World J. Gastroenterol. 2004)
    9. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51020 HGNC: 21078 AceView: C6orf74 Ensembl:ENSG00000111906 euGenes: HUgn51020
    ECgene: HDDC2 H-InvDB: HDDC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HDDC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HDDC2 gene:
    Search GeneIP for patents involving HDDC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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