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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HDC Gene

protein-coding   GIFtS: 65
GCID: GC15M050534

Histidine Decarboxylase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histidine Decarboxylase1 2
EC 4.1.1.223 8
EC 4.1.18

External Ids:    HGNC: 48551   Entrez Gene: 30672   Ensembl: ENSG000001402877   OMIM: 1427045   UniProtKB: P191133   

Export aliases for HDC gene to outside databases

Previous GC identifers: GC15M046091 GC15M043580 GC15M048113 GC15M048250 GC15M048321 GC15M027365


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HDC Gene:
This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to
histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including
neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.(provided by RefSeq, Aug 2010)

GeneCards Summary for HDC Gene: 
HDC (histidine decarboxylase) is a protein-coding gene. Diseases associated with HDC include mast cell neoplasm, and mastocytosis, and among its related super-pathways are Metabolic pathways and histidine degradation VI. GO annotations related to this gene include histidine decarboxylase activity and pyridoxal phosphate binding. An important paralog of this gene is DDC.

UniProtKB/Swiss-Prot: DCHS_HUMAN, P19113
Function: Catalyzes the biosynthesis of histamine from histidine

Gene Wiki entry for HDC (Histidine decarboxylase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HDC gene promoter:
         GR   Sp1   FOXD3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   FOXO4   FOXJ2 (long isoform)   GR-alpha   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHDC promoter sequence
   Search SABiosciences Chromatin IP Primers for HDC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

HDC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDC gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M050534:  view genomic region     (about GC identifiers)

Start:
50,534,144 bp from pter      End:
50,558,223 bp from pter
Size:
24,080 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DCHS_HUMAN, P19113 (See protein sequence)
Recommended Name: Histidine decarboxylase  
Size: 662 amino acids; 74141 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for HDC:
4E1O (3D)    
Secondary accessions: A1L4G0

Explore the universe of human proteins at neXtProt for HDC: NX_P19113

Explore proteomics data for HDC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P19113

  • 4/7 DME Specific Peptides for HDC (P19113) (see all 7)
     QLPCCPL  SPACTELE  SDQAHSSVE  HWQSPHMHAY 

    HDC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HDC Protein Expression
    REFSEQ proteins: NP_002103.2  
    ENSEMBL proteins: 
     ENSP00000267845   ENSP00000440252   ENSP00000453183  
    Reactome Protein details: P19113
    Human Recombinant Protein Products for HDC: 
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    Novus Biologicals HDC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HDC 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    HDC for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Histidine decarboxylase 
    Decarboxylases

    5/6 InterPro protein domains (see all 6):
     IPR002129 PyrdxlP-dep_de-COase
     IPR021115 Pyridoxal-P_BS
     IPR010977 Aromatic_deC
     IPR015422 PyrdxlP-dep_Trfase_major_sub2
     IPR015424 PyrdxlP-dep_Trfase

    Graphical View of Domain Structure for InterPro Entry P19113

    ProtoNet protein and cluster: P19113

    2 Blocks protein domains:
    IPB002129 Pyridoxal-dependent decarboxylase
    IPB010977 Aromatic-L-amino-acid decarboxylase


    UniProtKB/Swiss-Prot: DCHS_HUMAN, P19113
    Similarity: Belongs to the group II decarboxylase family


    HDC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCHS_HUMAN, P19113
    Function: Catalyzes the biosynthesis of histamine from histidine
    Catalytic activity: L-histidine = histamine + CO(2)
    Biophysicochemical properties: Kinetic parameters: KM=0.1 mM for histidine; Vmax=1880 nmol/min/mg enzyme;

         Genatlas biochemistry entry for HDC:
    histidine decarboxylase,brain,catalyzing the histidine synthesis

         Enzyme Numbers (IUBMB): EC 4.1.1.221 2 EC 4.1.12

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004398histidine decarboxylase activity TAS--
    GO:0016831carboxy-lyase activity ----
    GO:0030170pyridoxal phosphate binding IEA--
         
    HDC for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hdc):
     adipose tissue  behavior/neurological  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  nervous system  no phenotypic analysis 

    HDC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hdctm1Nagy for HDC

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HDC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HDC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HDC 
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    SwitchGear 3'UTR luciferase reporter plasmidHDC 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of HDC 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HDC About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2Histidine catabolism
    Histidine catabolism0.60
    3Regulation of thyroid hormone activity
    Biogenic Amine Synthesis0.32
    4histamine biosynthesis
    histamine biosynthesis
    5Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for HDC
        Biogenic Amine Synthesis
    histamine biosynthesis

    3        Reactome Pathways for HDC
        Histidine catabolism
    Metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for HDC):
        Histidine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: DCHS_HUMAN, P19113
    Pathway: Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1


    HDC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HDC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/13 Interacting proteins for HDC (P191133 ENSP000002678454) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GL3Q999633I2D: score=5 
    AOC1ENSP000003541934STRING: ENSP00000354193
    CNDP1ENSP000003516824STRING: ENSP00000351682
    HALENSP000002612084STRING: ENSP00000261208
    HNMTENSP000002800974STRING: ENSP00000280097
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001694histamine biosynthetic process IEA--
    GO:0006520cellular amino acid metabolic process ----
    GO:0006547histidine metabolic process TAS1487235
    GO:0006548histidine catabolic process TAS--
    GO:0019752carboxylic acid metabolic process ----

    HDC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HDC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HDC (DCHS)

    10/11 HMDB Compounds for HDC (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CarnosineBeta-Alanyl-L-histidine (see all 14)305-84-03095942
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Histamine1H-Imidazole-4-ethanamine (see all 27)51-45-6--
    L-Histidine(S)-1H-Imidazole-4-alanine (see all 20)71-00-1--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    NorspermidineN-(3-aminopropyl)-1,3-Propanediamine (see all 28)56-18-8--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--
    Spermidine1,5,10-Triazadecane (see all 15)124-20-9--

    2 DrugBank Compounds for HDC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Histidine(S)-4-(2-Amino-2-carboxyethyl)imidazole (see all 7)71-00-1target--17191019 17227057 16790022 16960050 17075268
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor16547811 11980912 16790022 12679420 15070923

    3 IUPHAR Ligands for HDC (Histidine decarboxylase)    About this table 
    LigandTypeActionAffinityPubmed IDs
    SAM486A
    InhibitorInhibition88340919
    AMA
    InhibitorInhibition8--
    FMH
    InhibitorInhibition87452304

    10/41 Novoseek inferred chemical compound relationships for HDC gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    histidine 93.6 478 10951267 (8), 12527716 (6), 7698611 (4), 18450547 (4) (see all 99)
    histamine 90.1 422 9865502 (5), 12972479 (5), 9736639 (4), 9654597 (4) (see all 99)
    alpha-fluoromethylhistidine 85.7 14 9062867 (1), 2053513 (1), 1341077 (1), 11246041 (1) (see all 11)
    loxtidine 82.1 5 20144901 (1), 8097370 (1), 10461353 (1), 10651065 (1)
    n,n-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 79.7 1 11556524 (1)
    triprolidine 65.6 1 11306145 (1)
    alendronic acid 60.8 1 10193770 (1)
    pyridoxal 5-phosphate 54.6 10 2124279 (1), 18756395 (1), 1487235 (1), 16790022 (1)
    hydrazine 52.9 10 1588129 (1), 19899403 (1), 1960592 (1), 8448680 (1) (see all 7)
    toluene diisocyanate 50 14 19596986 (4), 1960592 (2), 8396495 (1)

    Search CenterWatch for drugs/clinical trials and news about HDC / DCHS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HDC gene: 
    NM_002112.3  

    Unigene Cluster for HDC:

    Histidine decarboxylase
    Hs.1481  [show with all ESTs]
    Unigene Representative Sequence: NM_002112
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559816(uc001zxy.3) ENST00000267845(uc001zxz.3 uc010uff.2)
    ENST00000543581 ENST00000558761(uc010bet.2) ENST00000559190 ENST00000558679(uc010beu.2)
    ENST00000559683
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate HDC:
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    SwitchGear 3'UTR luciferase reporter plasmidHDC 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK027221.1 AK308833.1 AK310479.1 AK311072.1 BC130527.1 BC144173.1 D10088.1 M60445.1 
    X54297.1 

    2 DOTS entries:

    DT.106248  DT.97792445 

    12 AceView cDNA sequences:

    D10088 BX107942 M60445 NM_002112 AI695885 X54297 AK027221 AL041199 
    CD703337 AW204882 CB266975 AW198195 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HDC expression in normal human tissues (normalized intensities)      HDC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATATAACA
    HDC Expression
    About this image


    HDC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             N2/LSB/S/F8-induced cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...
             Septum   
     
     Kidney (Urinary System)    fully expand to see all 11 entries
             Proximal Tubule Cells Proximal Tubule
             Proximal Tubule
             visceral organ/metanephros/renal medulla   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Umbilical cord blood-derived hematopoietic stem cells
             Fetal Liver CD36+ Cells   
             mouse/organ system/cardiovascular system   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 5 entries
             Ureter
             visceral organ   
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             heart/atrium   

    See HDC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HDC

    SOURCE GeneReport for Unigene cluster: Hs.1481
        SABiosciences Expression via Pathway-Focused PCR Array including HDC: 
              Amino Acid Metabolism II in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HDC gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hdc1 , 5 histidine decarboxylase1, 5 85.85(n)1
    87.79(a)1
      2 (61.76 cM)5
    151861  NM_008230.51  NP_032256.31 
     1265936675 
    chicken
    (Gallus gallus)
    Aves HDC1 histidine decarboxylase 72.88(n)
    77.71(a)
      415454  XM_413833.2  XP_413833.1 
    lizard
    (Anolis carolinensis)
    Reptilia HDC6
    Uncharacterized protein
    70(a)
    1 ↔ 1
    GL343747.1(20363-39389)
    zebrafish
    (Danio rerio)
    Actinopterygii hdc1 histidine decarboxylase 66.93(n)
    68.76(a)
      793609  NM_001102593.1  NP_001096063.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hdc1 , 3 eye photoreceptor development (sensu
    Drosophila) histidine decarboxylase less3
    Histidine decarboxylase1
    61(a)
    (best of 5)3
    60.99(n)1
    61.76(a)1
      2 46F73
    360761  NM_078955.21  NP_523679.21 
    worm
    (Caenorhabditis elegans)
    Secernentea tdc-13 aromatic-L-amino-acid decarboxylase 48(a)
    (best of 4)
      II(8270530-8273464)   --
    wheat
    (Triticum aestivum)
    Liliopsida BT009489.12   -- 72.11(n)    BT009489.1 


    ENSEMBL Gene Tree for HDC (if available)
    TreeFam Gene Tree for HDC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HDC gene
    DDC2  GAD12  GADL12  GAD22  CSAD2  
    2 SIMAP similar genes for HDC using alignment to 4 protein entries:     DCHS_HUMAN (see all proteins):
    DDC    CSAD

    HDC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/624 SNPs in HDC are shown (see all 624)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364714
    A colorectal cancer sample4--see VAR_0364712 E K mis40--------
    VAR_0364704
    A colorectal cancer sample4--see VAR_0364702 E V mis40--------
    rs354370831,2
    C--27383157(+) CATTC-/TTTTTTT 1 -- int11Minor allele frequency- TT:0.00NA 2
    rs1810838351,2
    C--30599983(+) ATACTC/TTTTAC 1 -- int10--------
    rs1866602581,2
    --30600057(+) TTGGCC/GTCTGA 1 -- int10--------
    rs1903761771,2
    --30600130(+) AAGGGA/GAAAAT 1 -- int10--------
    rs1437181881,2
    --30600180(+) CTGGAG/TGACCA 1 -- int10--------
    rs1159552111,2
    C,F--30600238(+) AGTACT/AGCATG 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1830118421,2
    --30600244(+) GCATGG/TTGGAA 1 -- int10--------
    rs743836511,2
    F--30600332(+) CATTTA/CTGAAC 1 -- int11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for HDC (50534144 - 50558223 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HDC:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1531CNV Insertion18451855
    nsv483038CNV Gain15286789


    Human Gene Mutation Database (HGMD): HDC
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for HDC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142704    OMIM disorders: --

    20/45 diseases for HDC (see all 45):    About MalaCards
    mast cell neoplasm    mastocytosis    peptic ulcer    systemic mastocytosis
    duodenal ulcer    duodenitis    pyloric stenosis    intestinal obstruction
    neuroendocrine tumor    t cell deficiency    urticaria    arteriosclerosis
    pheochromocytoma    scleroderma    allergic rhinitis    prader-willi syndrome
    rhinitis    bronchiolitis    encephalomyelitis    brain injury

    2 diseases from the University of Copenhagen DISEASES database for HDC:
    Mastocytosis     Hypersensitivity reaction type I disease

    HDC for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/32 Novoseek inferred disease relationships for HDC gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia basophilic 56.6 5 8569054 (1), 9192736 (1), 2117926 (1)
    carcinoid 52.4 8 16517981 (2), 9516403 (2), 10651065 (2), 15144399 (1) (see all 5)
    mastocytoma 47.5 12 1310051 (3), 7853145 (3), 17360717 (2), 9561410 (1)
    gastric disorder 46.5 3 11790728 (1)
    mastocytosis systemic 43.6 2 16564918 (2)
    nasal polyps 26.3 3 8448680 (2), 1960592 (1)
    carcinoma medullary 26.1 2 15144399 (1), 12527716 (1)
    mastocytosis 25 1 16564918 (1)
    neuroendocrine tumors 24.1 5 16517981 (2), 15144399 (2)
    allergy 24.1 3 20232648 (1), 16776680 (1)

    Genetic Association Database (GAD): HDC
    Human Genome Epidemiology (HuGE) Navigator: HDC (12 documents)

    Export disorders for HDC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HDC gene, integrated from 9 sources (see all 243):
    (articles sorted by number of sources associating them with HDC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the cDNA encoding human histidine decarboxylase from an erythroleukemia cell line and mapping of the gene locus to chromosome 15. (PubMed id 1768863)1, 2, 9 Zahnow C.A.... Joseph D.R. (1991)
    2. Structure of the L-histidine decarboxylase gene. (PubMed id 8288622)1, 2, 9 Yatsunami K.... Ichikawa A. (1994)
    3. HDC gene polymorphisms are associated with age at natural menopause in Caucasian women. (PubMed id 16919600)1, 4, 9 Zhang F....Deng H.W. (2006)
    4. Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. (PubMed id 1487235)1, 3, 9 Bruneau G....Thibault J. (1992)
    5. Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells. (PubMed id 12679420)1, 7, 9 Skoldberg F....Kampe O. (2003)
    6. Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase. (PubMed id 22767596)1, 2 Komori H.... Higuchi Y. (2012)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    8. Variability of the L-Histidine decarboxylase gene in allergic rhinitis. (PubMed id 20608921)1, 4 Gervasini G....GarcA-a-MartA-n E. (2010)
    9. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    10. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3067 HGNC: 4855 AceView: HDC Ensembl:ENSG00000140287 euGenes: HUgn3067
    ECgene: HDC Kegg: 3067 H-InvDB: HDC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HDC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HDC gene:
    Search GeneIP for patents involving HDC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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