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Aliases for HDC Gene

Aliases for HDC Gene

  • Histidine Decarboxylase 2 3 5
  • EC 4 63
  • EC 4.1.1 63

External Ids for HDC Gene

Previous GeneCards Identifiers for HDC Gene

  • GC15M046091
  • GC15M043580
  • GC15M048113
  • GC15M048250
  • GC15M048321
  • GC15M050534
  • GC15M027365

Summaries for HDC Gene

Entrez Gene Summary for HDC Gene

  • This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]

GeneCards Summary for HDC Gene

HDC (Histidine Decarboxylase) is a Protein Coding gene. Diseases associated with HDC include Gilles De La Tourette Syndrome and Mast Cell Neoplasm. Among its related pathways are Histidine metabolism and Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism. GO annotations related to this gene include pyridoxal phosphate binding and histidine decarboxylase activity. An important paralog of this gene is DDC.

UniProtKB/Swiss-Prot for HDC Gene

  • Catalyzes the biosynthesis of histamine from histidine.

Gene Wiki entry for HDC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDC Gene

Genomics for HDC Gene

Regulatory Elements for HDC Gene

Enhancers for HDC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HDC on UCSC Golden Path with GeneCards custom track

Genomic Location for HDC Gene

50,241,945 bp from pter
50,266,091 bp from pter
24,147 bases
Minus strand

Genomic View for HDC Gene

Genes around HDC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDC Gene

Proteins for HDC Gene

  • Protein details for HDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histidine decarboxylase
    Protein Accession:
    Secondary Accessions:
    • A1L4G0
    • B7ZM01

    Protein attributes for HDC Gene

    662 amino acids
    Molecular mass:
    74141 Da
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for HDC Gene

    Alternative splice isoforms for HDC Gene


neXtProt entry for HDC Gene

Proteomics data for HDC Gene at MOPED

Post-translational modifications for HDC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HDC Gene

Antibody Products

Domains & Families for HDC Gene

Gene Families for HDC Gene

Suggested Antigen Peptide Sequences for HDC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the group II decarboxylase family.
  • Belongs to the group II decarboxylase family.
genes like me logo Genes that share domains with HDC: view

Function for HDC Gene

Molecular function for HDC Gene

GENATLAS Biochemistry:
histidine decarboxylase,brain,catalyzing the histidine synthesis
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.1 mM for histidine {ECO:0000269 PubMed:22767596}; Vmax=1880 nmol/min/mg enzyme {ECO:0000269 PubMed:22767596};
UniProtKB/Swiss-Prot CatalyticActivity:
L-histidine = histamine + CO(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the biosynthesis of histamine from histidine.

Enzyme Numbers (IUBMB) for HDC Gene

genes like me logo Genes that share phenotypes with HDC: view

Animal Models for HDC Gene

MGI Knock Outs for HDC:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HDC Gene

Localization for HDC Gene

Subcellular locations from

Jensen Localization Image for HDC Gene COMPARTMENTS Subcellular localization image for HDC gene
Compartment Confidence
cytosol 5
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HDC Gene

Pathways & Interactions for HDC Gene

genes like me logo Genes that share pathways with HDC: view

UniProtKB/Swiss-Prot P19113-DCHS_HUMAN

  • Pathway: Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1.

Gene Ontology (GO) - Biological Process for HDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006548 histidine catabolic process IDA,TAS 22767596
GO:0042423 catecholamine biosynthetic process IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with HDC: view

No data available for SIGNOR curated interactions for HDC Gene

Drugs & Compounds for HDC Gene

(24) Drugs for HDC Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Histidine Approved Nutra Target 0
spermine Approved Nutra Full agonist, Agonist 0
Pyruvic acid Approved Nutra 0
spermidine Experimental Pharma Antagonist, Pore Blocker 0
putrescine Experimental Pharma Antagonist, Pore Blocker 0

(29) Additional Compounds for HDC Gene - From: Novoseek, HMDB, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Inhibition, Inhibitor
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
  • b-Alanyl-L-histidine
  • b-Alanylhistidine
  • beta-Alanyl-L-histidine
  • beta-Alanylhistidine
  • Carnosine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
  • -1,3-propanediamine
  • 1,7-Diamino-4-azaheptane
  • 3, 3'-Diaminodipropylamine
  • 3, {3'-Iminobis[propylamine]}
  • 3,3'-Diamino-Dipropylamine
genes like me logo Genes that share compounds with HDC: view

Transcripts for HDC Gene

mRNA/cDNA for HDC Gene

Unigene Clusters for HDC Gene

Histidine decarboxylase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HDC Gene

No ASD Table

Relevant External Links for HDC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HDC Gene

mRNA expression in normal human tissues for HDC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HDC Gene

This gene is overexpressed in Brain - Hypothalamus (x28.0).

Protein differential expression in normal tissues from HIPED for HDC Gene

This gene is overexpressed in Urine (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HDC Gene

SOURCE GeneReport for Unigene cluster for HDC Gene Hs.1481

genes like me logo Genes that share expression patterns with HDC: view

Protein tissue co-expression partners for HDC Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HDC Gene

Orthologs for HDC Gene

This gene was present in the common ancestor of animals.

Orthologs for HDC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HDC 35
  • 89.87 (n)
  • 91.49 (a)
HDC 36
  • 91 (a)
(Canis familiaris)
Mammalia HDC 35
  • 91.39 (n)
  • 92.6 (a)
HDC 36
  • 92 (a)
(Mus musculus)
Mammalia Hdc 35
  • 85.9 (n)
  • 87.79 (a)
Hdc 16
Hdc 36
  • 87 (a)
(Pan troglodytes)
Mammalia HDC 35
  • 99.7 (n)
  • 99.55 (a)
HDC 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hdc 35
  • 86.15 (n)
  • 87.69 (a)
(Monodelphis domestica)
Mammalia HDC 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia HDC 36
  • 57 (a)
(Gallus gallus)
Aves HDC 35
  • 73.03 (n)
  • 77.71 (a)
HDC 36
  • 77 (a)
(Anolis carolinensis)
Reptilia HDC 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hdc 35
  • 70.24 (n)
  • 74.07 (a)
(Danio rerio)
Actinopterygii hdc 35
  • 66.86 (n)
  • 68.76 (a)
hdc 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta amd 37
  • 38 (a)
CG30445 37
  • 49 (a)
CG30446 37
  • 49 (a)
Ddc 37
  • 51 (a)
Hdc 37
  • 61 (a)
Hdc 35
  • 60.99 (n)
  • 61.76 (a)
Hdc 36
  • 40 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009001 35
  • 61.66 (n)
  • 62.88 (a)
(Caenorhabditis elegans)
Secernentea C05D2.3 37
  • 33 (a)
F12A10.3 37
  • 30 (a)
tdc-1 37
  • 48 (a)
ZK829.2 37
  • 39 (a)
hdl-1 36
  • 22 (a)
tdc-1 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
-- 36
  • 22 (a)
Species with no ortholog for HDC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDC Gene

Gene Tree for HDC (if available)
Gene Tree for HDC (if available)

Paralogs for HDC Gene

Paralogs for HDC Gene

(2) SIMAP similar genes for HDC Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HDC: view

Variants for HDC Gene

Sequence variations from dbSNP and Humsavar for HDC Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2073440 - 50,242,317(-) CCTGA(A/C)TGCAG reference, missense
VAR_036470 A colorectal cancer sample
VAR_036471 A colorectal cancer sample
rs17740607 - 50,263,347(+) CTGGC(A/G)TCACA reference, missense
rs16963486 - 50,242,592(+) TGAAA(A/G)GCAGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HDC Gene

Variant ID Type Subtype PubMed ID
nsv483038 CNV Gain 15286789
nsv1531 CNV Insertion 18451855

Variation tolerance for HDC Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.65; 72.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HDC Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDC Gene

Disorders for HDC Gene

MalaCards: The human disease database

(8) MalaCards diseases for HDC Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gilles de la tourette syndrome
  • tourette syndrome
mast cell neoplasm
  • mast cell proliferative disease
systemic mastocytosis
  • smcd
stomach disease
  • gastric disease
pyloric stenosis
- elite association - COSMIC cancer census association via MalaCards
Search HDC in MalaCards View complete list of genes associated with diseases

Relevant External Links for HDC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HDC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HDC Gene

Publications for HDC Gene

  1. Cloning of the cDNA encoding human histidine decarboxylase from an erythroleukemia cell line and mapping of the gene locus to chromosome 15. (PMID: 1768863) Zahnow C.A. … Joseph D.R. (DNA Seq. 1991) 3 4 23 67
  2. Food components inhibiting recombinant human histidine decarboxylase activity. (PMID: 17227057) Nitta Y. … Ueno H. (J. Agric. Food Chem. 2007) 23 25 26
  3. Histamine, histidine, and growth-phase mediated regulation of the histidine decarboxylase gene in lactic acid bacteria isolated from wine. (PMID: 16790022) Landete J.M. … Ferrer S. (FEMS Microbiol. Lett. 2006) 23 25 26
  4. Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line. (PMID: 17191019) Castellani M.L. … Vecchiet J. (Neuroimmunomodulation 2006) 23 25 26
  5. Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells. (PMID: 12679420) SkAPldberg F. … KAompe O. (J. Clin. Endocrinol. Metab. 2003) 3 23 25

Products for HDC Gene

Sources for HDC Gene