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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HDC Gene

protein-coding   GIFtS: 64
GCID: GC15M050534

histidine decarboxylase
 Explore 51 diseases affiliated with
HDC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HDC    

Aliases
for HDC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histidine Decarboxylase1 2
EC 4.1.1.223 8
EC 4.1.18

External Ids:    HGNC: 48551   Entrez Gene: 30672   Ensembl: ENSG000001402877   OMIM: 1427045   UniProtKB: P191133   

Export aliases for HDC gene to outside databases

Previous GC identifers: GC15M046091 GC15M043580 GC15M048113 GC15M048250 GC15M048321 GC15M027365


Summaries
for HDC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HDC:
This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to
histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including
neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.(provided by RefSeq, Aug 2010)

UniProtKB/Swiss-Prot: DCHS_HUMAN, P19113
Function: Catalyzes the biosynthesis of histamine from histidine

Gene Wiki entry for HDC (Histidine decarboxylase)


Genomic Views
for HDC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HDC gene promoter:
         GR   Sp1   FOXD3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   FOXO4   FOXJ2 (long isoform)   GR-alpha   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HDC promoter sequence
   Search SABiosciences Chromatin IP Primers for HDC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21-q22   Ensembl cytogenetic band:  15q21.2   HGNC chromosome: 15

HDC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDC gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M050534:  view genomic region     (about GC identifiers)

Start:
 50,534,144 bp from pter      End:
 50,558,259 bp from pter
Size:
 24,116 bases      Orientation:
 minus strand

Proteins
for HDC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DCHS_HUMAN, P19113 (See protein sequence)
Recommended Name: Histidine decarboxylase  
Size: 662 amino acids; 74141 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for HDC:
4E1O (3D)    
Secondary accessions: A1L4G0

Explore the universe of human proteins at neXtProt for HDC: NX_P19113

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P19113

    • 4/7 DME Specific Peptides for HDC (P19113) (see all 7)
     QLPCCPL  SPACTELE  SDQAHSSVE  HWQSPHMHAY 

    HDC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002103.2  
    ENSEMBL proteins: 
     ENSP00000267845   ENSP00000440252   ENSP00000453183   ENSP00000453165  
    Reactome Protein details: P19113
    Human Recombinant Protein Products: 
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    Novus Biologicals HDC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HDC

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005626insoluble fraction ----
    GO:0005829cytosol TAS--
    GO:0030425dendrite ----
    GO:0043025neuronal cell body ----


    HDC for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HDC

    Protein Domains /
    Families
    for HDC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HDC for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR002129 PyrdxlP-dep_de-COase
     IPR021115 Pyridoxal-P_BS
     IPR010977 Aromatic_deC
     IPR015422 PyrdxlP-dep_Trfase_major_sub2
     IPR015424 PyrdxlP-dep_Trfase

    Graphical View of Domain Structure for InterPro Entry P19113

    ProtoNet protein and cluster: P19113

    2 Blocks protein families:
    IPB002129 Pyridoxal-dependent decarboxylase
    IPB010977 Aromatic-L-amino-acid decarboxylase


    UniProtKB/Swiss-Prot: DCHS_HUMAN, P19113
    Similarity: Belongs to the group II decarboxylase family


    Function
    for HDC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DCHS_HUMAN, P19113
    Function: Catalyzes the biosynthesis of histamine from histidine
    Catalytic activity: L-histidine = histamine + CO(2)
    Biophysicochemical properties: Kinetic parameters: KM=0.1 mM for histidine; Vmax=1880 nmol/min/mg enzyme;

         Genatlas biochemistry entry for HDC:
    histidine decarboxylase,brain,catalyzing the histidine synthesis

    Enzyme Numbers (IUBMB): EC 4.1.1.221 2 EC 4.1.12

    miRNA
    Products:            		 OriGene 3'-UTR Clone: HDC
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HDC
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate HDC:
    hsa-miR-140-3p hsa-miR-513b hsa-miR-1914*
    SwitchGear 3'UTR luciferase reporter plasmid: HDC 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDC (see all 7)
    OriGene shRNA RFP: HDC
    OriGene siRNA: HDC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HDC

    Clone
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    GenScript: all cDNA clones in your preferred vector: HDC (NM_002112)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDC 

    Cell Line
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    Search LifeMap BioReagents cell lines for HDC

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDC

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004398histidine decarboxylase activity TAS--
    GO:0016597amino acid binding ----
    GO:0016831carboxy-lyase activity ----
    GO:0030170pyridoxal phosphate binding IEA--


    HDC for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Hdctm1Nagy for HDC
         9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Hdc):
     adipose tissue  behavior/neurological  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  nervous system  no phenotypic analysis 

    HDC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HDC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    2Metabolism of amino acids and derivatives
    		Metabolism of amino acids and derivatives1.00
    3Histidine catabolism
    		Histidine catabolism1.00
    4histamine biosynthesis
    		histamine biosynthesis1.00
    5Histidine metabolism
    		Histidine metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for HDC 
        Biogenic Amine Synthesis
    histamine biosynthesis

    3        Reactome Pathways for HDC
        Histidine catabolism
    Metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for HDC):
        Histidine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: DCHS_HUMAN, P19113
    Pathway: Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1


    HDC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HDC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/13 Interacting proteins for HDC (P191133 ENSP000002678454) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GL3Q999633I2D: score=5 
    ABP1ENSP000003541934STRING: ENSP00000354193
    CNDP1ENSP000003516824STRING: ENSP00000351682
    HALENSP000002612084STRING: ENSP00000261208
    HNMTENSP000002800974STRING: ENSP00000280097
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001692histamine metabolic process ----
    GO:0001694histamine biosynthetic process IEA--
    GO:0006520cellular amino acid metabolic process ----
    GO:0006547histidine metabolic process TAS1487235
    GO:0006548histidine catabolic process TAS--


    HDC for ontologies           About GeneDecksing



    Drugs & Compounds
    for HDC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HDC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HDC

    10/11 HMDB Compounds for HDC (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CarnosineBeta-Alanyl-L-histidine (see all 14)305-84-03095942
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Histamine1H-Imidazole-4-ethanamine (see all 27)51-45-6--
    L-Histidine(S)-1H-Imidazole-4-alanine (see all 20)71-00-1--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    NorspermidineN-(3-aminopropyl)-1,3-Propanediamine (see all 28)56-18-8--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--
    Spermidine1,5,10-Triazadecane (see all 15)124-20-9--

    2 DrugBank Compounds for HDC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Histidine(S)-4-(2-Amino-2-carboxyethyl)imidazole (see all 7)71-00-1target--17191019 17227057 16790022 16960050 17075268
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor16547811 11980912 16790022 12679420 15070923

    10/41 Novoseek chemical compound relationships for HDC gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    histidine 93.6 478 10951267 (8), 12527716 (6), 7698611 (4), 18450547 (4) (see all 99)
    histamine 90.1 422 9865502 (5), 12972479 (5), 9736639 (4), 9654597 (4) (see all 99)
    alpha-fluoromethylhistidine 85.7 14 9062867 (1), 2053513 (1), 1341077 (1), 11246041 (1) (see all 11)
    loxtidine 82.1 5 20144901 (1), 8097370 (1), 10461353 (1), 10651065 (1)
    n,n-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 79.7 1 11556524 (1)
    triprolidine 65.6 1 11306145 (1)
    alendronic acid 60.8 1 10193770 (1)
    pyridoxal 5-phosphate 54.6 10 2124279 (1), 18756395 (1), 1487235 (1), 16790022 (1)
    hydrazine 52.9 10 1588129 (1), 19899403 (1), 1960592 (1), 8448680 (1) (see all 7)
    toluene diisocyanate 50 14 19596986 (4), 1960592 (2), 8396495 (1)

    Search CenterWatch for drugs/clinical trials and news about HDC / DCHS 

    Transcripts
    for HDC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HDC gene: 
    NM_002112.3  

    Unigene Cluster for HDC:

    Histidine decarboxylase
    Hs.1481  [show with all ESTs]
    Unigene Representative Sequence: NM_002112
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559816(uc001zxy.3) ENST00000267845(uc001zxz.3 uc010uff.2)
    ENST00000543581 ENST00000558761(uc010bet.2) ENST00000559190 ENST00000558679(uc010beu.2)
    ENST00000559683 ENST00000559513

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HDC
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate HDC:
    hsa-miR-140-3p hsa-miR-513b hsa-miR-1914*
    SwitchGear 3'UTR luciferase reporter plasmid: HDC 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK027221.1 AK308833.1 AK310479.1 AK311072.1 BC130527.1 BC144173.1 D10088.1 M60445.1 
    X54297.1 

    2 DOTS entries:

    DT.106248  DT.97792445 

    12 AceView cDNA sequences:

    BX107942 M60445 D10088 NM_002112 AI695885 X54297 AL041199 AK027221 
    CD703337 AW204882 CB266975 AW198195 

    GeneLoc Exon Structure


    Expression
    for HDC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HDC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATATATAACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HDC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyDistal TubuleDistal Tubule CellsKidney
    KidneyLoop of HenleLoop of Henle CellsKidney
    KidneyProximal TubuleProximal Tubule CellsKidney
    OvaryAntral FollicleMature Granulosa CellsOvary
    HeartAtrioventricular CanalHeart
    KidneyDistal TubuleKidney
    KidneyEpithelial TubuleKidney
    KidneyLoop of HenleKidney
    KidneyMetanephrosKidney
    KidneyProximal TubuleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    N2/LSB/S/F8-induced cells (Generation of midbra...)

    See HDC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HDC

    SOURCE GeneReport for Unigene cluster: Hs.1481
        SABiosciences Expression via Pathway-Focused PCR Array including HDC: 
              Amino Acid Metabolism II in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for HDC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HDC gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HDC1 histidine decarboxylase 72.88(n)
    77.71(a)    		   415454  XM_413833.2  XP_413833.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HDC6
    		 --
    		 70(a)
    		 1 ↔ 1
    		 GL343747.1(20363-39389)
    zebrafish
    (Danio rerio)    		 Actinopterygii hdc1 histidine decarboxylase 66.93(n)
    68.76(a)    		   793609  NM_001102593.1  NP_001096063.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Hdc1 , 3 eye photoreceptor development (sensu
    Drosophila) histidine decarboxylase less3
    Histidine decarboxylase1    		 61(a)
    (best of 5)3
    60.99(n)1
    61.76(a)1    		   2 46F73
    360761  NM_078955.21  NP_523679.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea tdc-13 aromatic-L-amino-acid decarboxylase 48(a)
    (best of 4)    		   II(8270530-8273464)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G203406
    TYRDC6
    		 tyrosine decarboxylase
    		 40(a)
    37(a)
    		 many ↔ many
    many ↔ many
    		 2(8779735-8782772)
    4(14155120-14158716)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 7)    		 decarboxylase, putative
    (see all 7)    		 42(a)
    36(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 7(14666999-14675714)
    10(12189485-12191065)


    ENSEMBL Gene Tree for HDC (if available)
    TreeFam Gene Tree for HDC (if available) 

    Paralogs
    for HDC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HDC gene
    DDC2  GAD12  GADL12  GAD22  CSAD2  
    2 SIMAP similar genes for HDC using alignment to 4 protein entries:     DCHS_HUMAN (see all proteins):
    DDC    CSAD

    HDC for paralogs           About GeneDecksing



    Genomic Variants
    for HDC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/486 NCBI SNPs in HDC are shown (see all 486)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs743836511,2
    		F,--27364968(+) CATTTA/CTGAAC 1 -- int11Minor allele frequency- C:0.02WA 118
    rs10424471,2
    		C--27365194(-) GTTCAT/GCAGTC 1 -- ut31 ese33Minor allele frequency- G:0.03MN NA 188
    rs800178671,2
    		C,--27365980(+) GGCAGC/GATCTC 2 P A mis10--------
    rs15735941,2
    		H--27366403(-) GTTCTC/TTTTAT 1 -- int15Minor allele frequency- T:0.00EA NS 434
    rs1129230331,2
    		--27366728(+) AAGTGA/GGGGCC 1 -- int12Minor allele frequency- G:0.03CSA WA 120
    rs1127009861,2
    		--27366816(+) TTGTAA/GTGCAC 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs799730661,2
    		--27367094(+) TAATGC/TCACTG 1 -- int10--------
    rs169634961,2
    		C,F,H,--27367380(+) CATACT/CTACTG 1 -- int125Minor allele frequency- C:0.11NA NS EA WA CSA 2437
    rs22382951,2
    		C,--27367561(-) aggagA/Gtgaag 1 -- int10--------
    rs783010911,2
    		--27368553(+) ATGATG/AGTGAT 1 -- int11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for HDC (50534144 - 50558259 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HDC
         1 CNV: 0188
    Human Gene Mutation Database (HGMD): HDC

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HDC
    DNA2.0 Custom Variant and Variant Library Synthesis for HDC

    Disorders / Diseases
    for HDC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HDC for disorders           About GeneDecksing

    OMIM gene information: 142704    OMIM disorders: --

    20/51 diseases for HDC (see all 51):    About MalaCards
    prader-willi syndrome    peptic ulcer    mast cell neoplasm    mastocytosis
    pyloric stenosis    duodenal ulcer    systemic mastocytosis    neuroendocrine tumor
    esophageal squamous cell carcinoma    allergic rhinitis    squamous cell carcinoma    bronchial asthma
    brain injury    duodenitis    myeloproliferative disorder    tourette syndrome
    carcinoid tumors    adrenocortical tumor    rhinitis    bronchiolitis

    1 disease from the University of Copenhagen DISEASES database for HDC:
    Mastocytosis

    10/32 Novoseek disease relationships for HDC gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia basophilic 56.6 5 8569054 (1), 9192736 (1), 2117926 (1)
    carcinoid 52.4 8 16517981 (2), 9516403 (2), 10651065 (2), 15144399 (1) (see all 5)
    mastocytoma 47.5 12 1310051 (3), 7853145 (3), 17360717 (2), 9561410 (1)
    gastric disorder 46.5 3 11790728 (1)
    mastocytosis systemic 43.6 2 16564918 (2)
    nasal polyps 26.3 3 8448680 (2), 1960592 (1)
    carcinoma medullary 26.1 2 15144399 (1), 12527716 (1)
    mastocytosis 25 1 16564918 (1)
    neuroendocrine tumors 24.1 5 16517981 (2), 15144399 (2)
    allergy 24.1 3 20232648 (1), 16776680 (1)

    Human Genome Epidemiology (HuGE) Navigator: HDC (12 documents)

    Export disorders for HDC gene to outside databases

    Publications
    for HDC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HDC gene, integrated from 9 sources (see all 241):
    (articles sorted by number of sources associating them with HDC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the cDNA encoding human histidine decarboxylase from an erythroleukemia cell line and mapping of the gene locus to chromosome 15. (PubMed id 1768863)1, 2, 9 Zahnow C.A.... Joseph D.R. (1991)
    2. Structure of the L-histidine decarboxylase gene. (PubMed id 8288622)1, 2, 9 Yatsunami K.... Ichikawa A. (1994)
    3. Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. (PubMed id 1487235)1, 3, 9 Bruneau G....Thibault J. (1992)
    4. Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells. (PubMed id 12679420)1, 7, 9 Skoldberg F....Kampe O. (2003)
    5. Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase. (PubMed id 22767596)1, 2 Komori H.... Higuchi Y. (2012)
    6. Functional analysis of alternatively spliced transcripts of the human histidine decarboxylase gene and its expression in human tissues and basophilic leukemia cells. (PubMed id 1425659)1, 2 Mamune-Sato R.... Takishima T. (1992)
    7. Nucleotide sequence of the cDNA encoding L-histidine decarboxylase derived from human basophilic leukemia cell line, KU-812-F. (PubMed id 2216786)1, 2 Yamauchi K.... Takishima T. (1990)
    8. Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression. (PubMed id 19266161)1, 9 Jeong H.J....Hong S.H. (2009)
    9. Food components inhibiting recombinant human histidine decarboxylase activity. (PubMed id 17227057)7, 9 Nitta Y....Ueno H. (2007)
    10. Upregulation of histidine decarboxylase expression in superficial cortical nephrons during pregnancy in mice and women. (PubMed id 16760908)1, 9 Morgan T.K....Higgins J.P. (2006)

    External Searches for HDC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HDC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3067 HGNC: 4855 AceView: HDC Ensembl:ENSG00000140287 euGenes: HUgn3067
    ECgene: HDC Kegg: 3067 H-InvDB: HDC

    Other Databases showing HDC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HDC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HDC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HDC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HDC gene:
    Search GeneIP for patents involving HDC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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