External Ids for HDC Gene
Previous GeneCards Identifiers for HDC Gene
This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]
GeneCards Summary for HDC Gene
HDC (Histidine Decarboxylase) is a Protein Coding gene. Diseases associated with HDC include gilles de la tourette syndrome and mast cell neoplasm. Among its related pathways are Metabolism and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include pyridoxal phosphate binding and histidine decarboxylase activity. An important paralog of this gene is DDC.
UniProtKB/Swiss-Prot for HDC Gene
Catalyzes the biosynthesis of histamine from histidine.