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HDC Gene

protein-coding   GIFtS: 63
GCID: GC15M050534

Histidine Decarboxylase

  See HDC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histidine Decarboxylase1 2
EC 4.1.1.223 8
EC 4.1.18

External Ids:    HGNC: 48551   Entrez Gene: 30672   Ensembl: ENSG000001402877   OMIM: 1427045   UniProtKB: P191133   

Export aliases for HDC gene to outside databases

Previous GC identifers: GC15M046091 GC15M043580 GC15M048113 GC15M048250 GC15M048321 GC15M027365


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HDC Gene:
This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to
histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including
neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.(provided by RefSeq, Aug 2010)

GeneCards Summary for HDC Gene:
HDC (histidine decarboxylase) is a protein-coding gene. Diseases associated with HDC include gilles de la tourette syndrome, and mastocytosis. GO annotations related to this gene include histidine decarboxylase activity and pyridoxal phosphate binding. An important paralog of this gene is DDC.

UniProtKB/Swiss-Prot: DCHS_HUMAN, P19113
Function: Catalyzes the biosynthesis of histamine from histidine

Gene Wiki entry for HDC (Histidine decarboxylase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the HDC gene promoter:
         GR   Sp1   FOXD3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   FOXO4   FOXJ2 (long isoform)   GR-alpha   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHDC promoter sequence
   Search Chromatin IP Primers for HDC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HDC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

HDC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDC gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M050534:  view genomic region     (about GC identifiers)

Start:
50,534,144 bp from pter      End:
50,558,223 bp from pter
Size:
24,080 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DCHS_HUMAN, P19113 (See protein sequence)
Recommended Name: Histidine decarboxylase  
Size: 662 amino acids; 74141 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for HDC:
4E1O (3D)    
Secondary accessions: A1L4G0

Explore the universe of human proteins at neXtProt for HDC: NX_P19113

Explore proteomics data for HDC at MOPED

Selected DME Specific Peptides for HDC (P19113) (see all 7)
 QLPCCPL  SPACTELE  SDQAHSSVE  HWQSPHMHAY 


See HDC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002103.2  
ENSEMBL proteins: 
 ENSP00000267845   ENSP00000440252   ENSP00000453183  
Reactome Protein details: P19113

HDC Human Recombinant Protein Products:

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Novus Biologicals HDC Lysate
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Browse Sino Biological Cell Lysates
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Cloud-Clone Corp. Proteins for HDC

 
Search eBioscience for Proteins for HDC 

 
antibodies-online proteins for HDC (6 products) 

 
antibodies-online peptides for HDC

HDC Antibody Products:

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HDC Assay Products:

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Cloud-Clone Corp. ELISAs for HDC
Cloud-Clone Corp. CLIAs for HDC
Search eBioscience for ELISAs for HDC 
antibodies-online kits for HDC (10 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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IUPHAR Guide to PHARMACOLOGY protein family classification: Histidine decarboxylase
Decarboxylases

Selected InterPro protein domains (see all 6):
 IPR002129 PyrdxlP-dep_de-COase
 IPR021115 Pyridoxal-P_BS
 IPR010977 Aromatic_deC
 IPR015422 PyrdxlP-dep_Trfase_major_sub2
 IPR015424 PyrdxlP-dep_Trfase

Graphical View of Domain Structure for InterPro Entry P19113

ProtoNet protein and cluster: P19113

2 Blocks protein domains:
IPB002129 Pyridoxal-dependent decarboxylase
IPB010977 Aromatic-L-amino-acid decarboxylase


UniProtKB/Swiss-Prot: DCHS_HUMAN, P19113
Similarity: Belongs to the group II decarboxylase family


Find genes that share domains with HDC           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DCHS_HUMAN, P19113
Function: Catalyzes the biosynthesis of histamine from histidine
Catalytic activity: L-histidine = histamine + CO(2)
Biophysicochemical properties: Kinetic parameters: KM=0.1 mM for histidine; Vmax=1880 nmol/min/mg enzyme;

     Genatlas biochemistry entry for HDC:
histidine decarboxylase,brain,catalyzing the histidine synthesis

     Enzyme Numbers (IUBMB): EC 4.1.1.221 2 EC 4.1.12

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004398histidine decarboxylase activity TAS--
GO:0016831carboxy-lyase activity ----
GO:0030170pyridoxal phosphate binding IEA--
     
Find genes that share ontologies with HDC           About GenesLikeMe


Phenotypes:
     9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hdc):
 adipose tissue  behavior/neurological  growth/size/body  hematopoietic system  homeostasis/metabolism 
 immune system  integument  nervous system  no phenotypic analysis 

Find genes that share phenotypes with HDC           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Hdctm1Nagy for HDC

   genOway: Develop your customized and physiologically relevant rodent model for HDC

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat HDC using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate HDC:
hsa-miR-140-3p hsa-miR-513b hsa-miR-1914*
SwitchGear 3'UTR luciferase reporter plasmidHDC 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for HDC
Predesigned siRNA for gene silencing in human, mouse, rat HDC

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for HDC

Clone
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OriGene clones in human, mouse for HDC (see all 7)
OriGene ORF clones in mouse, rat for HDC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HDC (NM_002112)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDC

Cell Line
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GenScript Custom overexpressing Cell Line Services for HDC
Browse ESI BIO Cell Lines and PureStem Progenitors for HDC 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDC


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
nucleus2
endoplasmic reticulum1
extracellular1
mitochondrion1
peroxisome1
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005829cytosol TAS--

Find genes that share ontologies with HDC           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for HDC About    
See pathways by source

SuperPathContained pathways About
1Histidine metabolism
Histidine metabolism
histamine biosynthesis0.00
Histidine catabolism0.00
2Metabolism
Metabolism0.38
Metabolic pathways0.38
3Metabolism of amino acids and derivatives
Metabolism of amino acids and derivatives
4Biogenic Amine Synthesis
Biogenic Amine Synthesis


Find genes that share SuperPaths with HDC           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 BioSystems Pathways for HDC
    Biogenic Amine Synthesis
histamine biosynthesis

1 Reactome Pathway for HDC
    Histidine catabolism


2 Kegg Pathways  (Kegg details for HDC):
    Histidine metabolism
Metabolic pathways

UniProtKB/Swiss-Prot: DCHS_HUMAN, P19113
Pathway: Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1

    Pathway & Disease-focused RT2 Profiler PCR Array including HDC: 

          Amino Acid Metabolism II in human mouse rat

Interactions:

    GeneGlobe Interaction Network for HDC

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

Selected Interacting proteins for HDC (P191133 ENSP000002678454) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
InteractantInteraction Details
GeneCardExternal ID(s)
SH3GL3Q999633I2D: score=5 
AOC1ENSP000003541934STRING: ENSP00000354193
CNDP1ENSP000003516824STRING: ENSP00000351682
HALENSP000002612084STRING: ENSP00000261208
HNMTENSP000002800974STRING: ENSP00000280097
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Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001694histamine biosynthetic process IEA--
GO:0006520cellular amino acid metabolic process ----
GO:0006547histidine metabolic process TAS1487235
GO:0006548histidine catabolic process TAS--
GO:0019752carboxylic acid metabolic process ----

Find genes that share ontologies with HDC           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HDC (DCHS)

Selected HMDB Compounds for HDC (see all 11)    About this table
CompoundSynonyms CAS #PubMed Ids
CarnosineBeta-Alanyl-L-histidine (see all 14)305-84-03095942
Carbon dioxideCarbon oxide (see all 5)124-38-9--
Histamine1H-Imidazole-4-ethanamine (see all 27)51-45-6--
L-Histidine(S)-1H-Imidazole-4-alanine (see all 20)71-00-1--
N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
NorspermidineN-(3-aminopropyl)-1,3-Propanediamine (see all 28)56-18-8--
Putrescine1,4-Butanediamine (see all 8)110-60-1--
Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--
Spermidine1,5,10-Triazadecane (see all 15)124-20-9--

2 DrugBank Compounds for HDC    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
L-Histidine(S)-4-(2-Amino-2-carboxyethyl)imidazole (see all 7)71-00-1target--17191019 17227057 16790022 16960050 17075268
Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor16547811 11980912 16790022 12679420 15070923

3 IUPHAR Ligands for HDC (Histidine decarboxylase)    About this table
LigandTypeActionAffinityPubmed IDs
SAM486A
InhibitorInhibition88340919
AMA
InhibitorInhibition8--
FMH
InhibitorInhibition87452304

Selected Novoseek inferred chemical compound relationships for HDC gene (see all 41)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
histidine 93.6 478 10951267 (8), 12527716 (6), 7698611 (4), 18450547 (4) (see all 99)
histamine 90.1 422 9865502 (5), 12972479 (5), 9736639 (4), 9654597 (4) (see all 99)
alpha-fluoromethylhistidine 85.7 14 9062867 (1), 2053513 (1), 1341077 (1), 11246041 (1) (see all 11)
loxtidine 82.1 5 20144901 (1), 8097370 (1), 10461353 (1), 10651065 (1)
n,n-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 79.7 1 11556524 (1)
triprolidine 65.6 1 11306145 (1)
alendronic acid 60.8 1 10193770 (1)
pyridoxal 5-phosphate 54.6 10 2124279 (1), 18756395 (1), 1487235 (1), 16790022 (1)
hydrazine 52.9 10 1588129 (1), 19899403 (1), 1960592 (1), 8448680 (1) (see all 7)
toluene diisocyanate 50 14 19596986 (4), 1960592 (2), 8396495 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for HDC gene: 
NM_002112.3  

Unigene Cluster for HDC:

Histidine decarboxylase
Hs.1481  [show with all ESTs]
Unigene Representative Sequence: NM_002112
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000559816(uc001zxy.3) ENST00000267845(uc001zxz.3 uc010uff.2)
ENST00000543581 ENST00000558761(uc010bet.2) ENST00000559190 ENST00000558679(uc010beu.2)
ENST00000559683
miRNA
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3 qRT-PCR Assays for microRNAs that regulate HDC:
hsa-miR-140-3p hsa-miR-513b hsa-miR-1914*
SwitchGear 3'UTR luciferase reporter plasmidHDC 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat HDC
Clone
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OriGene ORF clones in mouse, rat for HDC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HDC (NM_002112)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDC
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for HDC
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HDC
  QuantiTect SYBR Green Assays in human, mouse, rat HDC
  QuantiFast Probe-based Assays in human, mouse, rat HDC

Additional mRNA sequence: 

AK027221.1 AK308833.1 AK310479.1 AK311072.1 BC130527.1 BC144173.1 D10088.1 M60445.1 
X54297.1 

2 DOTS entries:

DT.106248  DT.97792445 

12 AceView cDNA sequences:

BX107942 M60445 D10088 AK027221 NM_002112 AI695885 X54297 AL041199 
AW204882 CD703337 CB266975 AW198195 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HDC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATATATAACA
HDC Expression
About this image


HDC expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 9) fully expand
 
 Kidney (Urinary System)    fully expand to see all 9 entries
         Loop of Henle Cells Loop of Henle
         Metanephros
 
 Epithelial Cells
         Loop of Henle Cells Loop of Henle
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Cerebellum
         N2/LSB/S/F8-induced cells
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Neural Tube (Nervous System)
         Floor plate-like cells
HDC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HDC Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.1481
    Pathway & Disease-focused RT2 Profiler PCR Array including HDC: 
          Amino Acid Metabolism II in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for HDC
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HDC
QuantiTect SYBR Green Assays in human, mouse, rat HDC
QuantiFast Probe-based Assays in human, mouse, rat HDC
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDC

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for HDC gene from Selected species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hdc1 , 5 histidine decarboxylase1, 5 85.9(n)1
87.79(a)1
  2 (61.76 cM)5
151861  NM_008230.61  NP_032256.31 
 1265936675 
chicken
(Gallus gallus)
Aves HDC1 histidine decarboxylase 73.03(n)
77.71(a)
  415454  XM_413833.3  XP_413833.1 
lizard
(Anolis carolinensis)
Reptilia HDC6
histidine decarboxylase
70(a)
1 ↔ 1
GL343747.1(20363-39389)
tropical clawed frog
(Xenopus tropicalis)
Amphibia hdc1 histidine decarboxylase 70.24(n)
74.07(a)
  100497702  XM_002939626.2  XP_002939672.2 
zebrafish
(Danio rerio)
Actinopterygii hdc1 histidine decarboxylase 66.86(n)
68.76(a)
  793609  NM_001102593.1  NP_001096063.1 
fruit fly
(Drosophila melanogaster)
Insecta Hdc1 , 3 eye photoreceptor development (sensu
Drosophila) histidine decarboxylase less3
Histidine decarboxylase1
61(a)
(best of 5)3
60.99(n)1
61.76(a)1
  2 46F73
360761  NM_001273926.11  NP_001260855.11 
worm
(Caenorhabditis elegans)
Secernentea tdc-13 aromatic-L-amino-acid decarboxylase 48(a)
(best of 4)
  II(8270530-8273464)   --
wheat
(Triticum aestivum)
Liliopsida BT009489.12   -- 72.11(n)    BT009489.1 


ENSEMBL Gene Tree for HDC (if available)
TreeFam Gene Tree for HDC (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HDC gene
DDC2  GAD12  GADL12  GAD22  CSAD2  
2 SIMAP similar genes for HDC using alignment to 3 protein entries:     DCHS_HUMAN (see all proteins):
DDC    CSAD

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HDC (see all 624)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0364714
A colorectal cancer sample4--see VAR_0364712 E K mis40--------
VAR_0364704
A colorectal cancer sample4--see VAR_0364702 E V mis40--------
rs354370831,2
C--27383157(+) CATTC-/TTTTTTT 1 -- int11Minor allele frequency- TT:0.00NA 2
rs1810838351,2
C--30599983(+) ATACTC/TTTTAC 1 -- int10--------
rs1866602581,2
--30600057(+) TTGGCC/GTCTGA 1 -- int10--------
rs1903761771,2
--30600130(+) AAGGGA/GAAAAT 1 -- int10--------
rs1437181881,2
--30600180(+) CTGGAG/TGACCA 1 -- int10--------
rs1159552111,2
C,F--30600238(+) AGTACT/AGCATG 1 -- int11Minor allele frequency- A:0.01WA 118
rs1830118421,2
--30600244(+) GCATGG/TTGGAA 1 -- int10--------
rs743836511,2
F--30600332(+) CATTTA/CTGAAC 1 -- int11Minor allele frequency- C:0.02WA 118

HapMap Linkage Disequilibrium report for HDC (50534144 - 50558223 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for HDC:    About this table    
Variant IDTypeSubtypePubMed ID
nsv1531CNV Insertion18451855
nsv483038CNV Gain15286789

Human Gene Mutation Database (HGMD): HDC
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HDC
DNA2.0 Custom Variant and Variant Library Synthesis for HDC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 142704   
OMIM disorders: 137580  
6 diseases for HDC:    
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gilles de la tourette syndrome    mastocytosis    intestinal obstruction    lymphoid leukemia
duodenal ulcer    colorectal cancer

2 diseases from the University of Copenhagen DISEASES database for HDC:
Mastocytosis     Hypersensitivity reaction type I disease

Find genes that share disorders with HDC           About GenesLikeMe

Selected Novoseek inferred disease relationships for HDC gene (see all 32)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia basophilic 56.6 5 8569054 (1), 9192736 (1), 2117926 (1)
carcinoid 52.4 8 16517981 (2), 9516403 (2), 10651065 (2), 15144399 (1) (see all 5)
mastocytoma 47.5 12 1310051 (3), 7853145 (3), 17360717 (2), 9561410 (1)
gastric disorder 46.5 3 11790728 (1)
mastocytosis systemic 43.6 2 16564918 (2)
nasal polyps 26.3 3 8448680 (2), 1960592 (1)
carcinoma medullary 26.1 2 15144399 (1), 12527716 (1)
mastocytosis 25 1 16564918 (1)
neuroendocrine tumors 24.1 5 16517981 (2), 15144399 (2)
allergy 24.1 3 20232648 (1), 16776680 (1)

Genetic Association Database (GAD): HDC
Human Genome Epidemiology (HuGE) Navigator: HDC (12 documents)

Export disorders for HDC gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HDC gene, integrated from 10 sources (see all 244):
(articles sorted by number of sources associating them with HDC)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of the cDNA encoding human histidine decarboxylase from an erythroleukemia cell line and mapping of the gene locus to chromosome 15. (PubMed id 1768863)1, 2, 9 Zahnow C.A.... Joseph D.R. (DNA Seq. 1991)
  2. Structure of the L-histidine decarboxylase gene. (PubMed id 8288622)1, 2, 9 Yatsunami K.... Ichikawa A. (J. Biol. Chem. 1994)
  3. HDC gene polymorphisms are associated with age at natural menopause in Caucasian women. (PubMed id 16919600)1, 4, 9 Zhang F....Deng H.W. (Biochem. Biophys. Res. Commun. 2006)
  4. Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. (PubMed id 1487235)1, 3, 9 Bruneau G....Thibault J. (Hum. Genet. 1992)
  5. Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells. (PubMed id 12679420)1, 7, 9 SkAPldberg F....KAompe O. (J. Clin. Endocrinol. Metab. 2003)
  6. Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase. (PubMed id 22767596)1, 2 Komori H.... Higuchi Y. (J. Biol. Chem. 2012)
  7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  8. Variability of the L-Histidine decarboxylase gene in allergic rhinitis. (PubMed id 20608921)1, 4 Gervasini G....GarcA-a-MartA-n E. (Allergy 2010)
  9. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  10. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3067 HGNC: 4855 AceView: HDC Ensembl:ENSG00000140287 euGenes: HUgn3067
ECgene: HDC Kegg: 3067 H-InvDB: HDC

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HDC Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HDC gene:
Search GeneIP for patents involving HDC

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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