External Ids for HDC Gene
Previous GeneCards Identifiers for HDC Gene
This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]
GeneCards Summary for HDC Gene
HDC (Histidine Decarboxylase) is a Protein Coding gene. Diseases associated with HDC include Gilles De La Tourette Syndrome and Mast Cell Neoplasm. Among its related pathways are Metabolism and Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism. GO annotations related to this gene include pyridoxal phosphate binding and histidine decarboxylase activity. An important paralog of this gene is DDC.
UniProtKB/Swiss-Prot for HDC Gene
Catalyzes the biosynthesis of histamine from histidine.