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Aliases for HDC Gene

Aliases for HDC Gene

  • Histidine Decarboxylase 2 3 5
  • EC 4.1.1.22 4 61
  • EC 4.1.1 61

External Ids for HDC Gene

Previous GeneCards Identifiers for HDC Gene

  • GC15M046091
  • GC15M043580
  • GC15M048113
  • GC15M048250
  • GC15M048321
  • GC15M050534
  • GC15M027365

Summaries for HDC Gene

Entrez Gene Summary for HDC Gene

  • This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]

GeneCards Summary for HDC Gene

HDC (Histidine Decarboxylase) is a Protein Coding gene. Diseases associated with HDC include Gilles De La Tourette Syndrome and Mast Cell Neoplasm. Among its related pathways are Metabolism and Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism. GO annotations related to this gene include pyridoxal phosphate binding and histidine decarboxylase activity. An important paralog of this gene is DDC.

UniProtKB/Swiss-Prot for HDC Gene

  • Catalyzes the biosynthesis of histamine from histidine.

Gene Wiki entry for HDC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDC Gene

Genomics for HDC Gene

Regulatory Elements for HDC Gene

Enhancers for HDC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F050259 1.7 FANTOM5 Ensembl ENCODE 22 +5.0 4991 4.2 PKNOX1 ATF1 ARNT ELK1 GATA2 JUNB NCOA1 TBX21 CREB3 MBD2 HDC MIR4712 GABPB1-AS1 ENSG00000259715 SLC27A2 ATP8B4 GABPB1 TRPM7 USP8 GC15M050253
GH15F050349 1.2 ENCODE 10.4 -87.2 -87178 8.3 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 GABPB1-AS1 ENSG00000259715 USP8 AHCYP7 ENSG00000259701 DCAF13P3 MIR4712 ENSG00000259298 FGF7 ENSG00000259618
GH15F050316 0.7 ENCODE 11.8 -50.2 -50158 0.1 CTCF ZNF654 TRIM22 REST RAD21 RFX5 CHAMP1 POLR2H PBX2 SMC3 HDC MIR4712 GABPB1-AS1 SLC27A2 ATP8B4 GC15P050317 GC15P050311
GH15F050226 0.6 ENCODE 12.4 +40.0 40013 0.2 GATAD2A ATF3 CEBPA HNF4G CEBPB CEBPG HDC SLC27A2 ENSG00000200605 GC15P050236
GH15F050190 0.4 Ensembl 11.9 +75.6 75591 0.2 MIXL1 HDC GC15P050186 GC15P050222
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HDC on UCSC Golden Path with GeneCards custom track

Genomic Location for HDC Gene

Chromosome:
15
Start:
50,241,945 bp from pter
End:
50,266,091 bp from pter
Size:
24,147 bases
Orientation:
Minus strand

Genomic View for HDC Gene

Genes around HDC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDC Gene

Proteins for HDC Gene

  • Protein details for HDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19113-DCHS_HUMAN
    Recommended name:
    Histidine decarboxylase
    Protein Accession:
    P19113
    Secondary Accessions:
    • A1L4G0
    • B7ZM01

    Protein attributes for HDC Gene

    Size:
    662 amino acids
    Molecular mass:
    74141 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for HDC Gene

    Alternative splice isoforms for HDC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDC Gene

Selected DME Specific Peptides for HDC Gene

P19113:
  • SDQAHSSVE
  • PSLLGDMLADAINCLGFTWASSPACTELE
  • QLPCCPL
  • SPACTELE
  • HWQSPHMHAY
  • NFSLRGEALQKAI
  • DFMHWQIPLSRRFR

Post-translational modifications for HDC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for HDC Gene

Gene Families for HDC Gene

Suggested Antigen Peptide Sequences for HDC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19113

UniProtKB/Swiss-Prot:

DCHS_HUMAN :
  • Belongs to the group II decarboxylase family.
Family:
  • Belongs to the group II decarboxylase family.
genes like me logo Genes that share domains with HDC: view

Function for HDC Gene

Molecular function for HDC Gene

GENATLAS Biochemistry:
histidine decarboxylase,brain,catalyzing the histidine synthesis
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.1 mM for histidine {ECO:0000269 PubMed:22767596}; Vmax=1880 nmol/min/mg enzyme {ECO:0000269 PubMed:22767596};
UniProtKB/Swiss-Prot CatalyticActivity:
L-histidine = histamine + CO(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the biosynthesis of histamine from histidine.

Enzyme Numbers (IUBMB) for HDC Gene

Gene Ontology (GO) - Molecular Function for HDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004398 histidine decarboxylase activity IEA,TAS --
GO:0005515 protein binding IPI 25416956
GO:0016829 lyase activity IEA --
GO:0016831 carboxy-lyase activity IEA --
genes like me logo Genes that share ontologies with HDC: view
genes like me logo Genes that share phenotypes with HDC: view

Animal Models for HDC Gene

MGI Knock Outs for HDC:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HDC Gene

Localization for HDC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDC gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HDC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HDC Gene

Pathways & Interactions for HDC Gene

genes like me logo Genes that share pathways with HDC: view

UniProtKB/Swiss-Prot P19113-DCHS_HUMAN

  • Pathway: Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1.

Gene Ontology (GO) - Biological Process for HDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001694 histamine biosynthetic process TAS --
GO:0006520 cellular amino acid metabolic process IEA --
GO:0006547 histidine metabolic process TAS 1487235
GO:0006548 histidine catabolic process IDA 22767596
GO:0019752 carboxylic acid metabolic process IEA --
genes like me logo Genes that share ontologies with HDC: view

No data available for SIGNOR curated interactions for HDC Gene

Drugs & Compounds for HDC Gene

(27) Drugs for HDC Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Histidine Approved Nutra Target 0
Histamine Approved Pharma Full agonist, Agonist 1034
spermine Approved Nutra Full agonist, Agonist 0
Carbon dioxide Approved, Vet_approved Pharma 0
Pyruvic acid Approved Nutra 0

(26) Additional Compounds for HDC Gene - From: Novoseek, HMDB, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SAM486A
Inhibition, Inhibitor
Carnosine
  • b-Alanyl-L-histidine
  • b-Alanylhistidine
  • beta-Alanyl-L-histidine
  • beta-Alanylhistidine
  • Carnosine
305-84-0
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
25593-72-0
Norspermidine
  • -1,3-propanediamine
  • 1,7-Diamino-4-azaheptane
  • 3, 3'-Diaminodipropylamine
  • 3, {3'-Iminobis[propylamine]}
  • 3,3'-Diamino-Dipropylamine
56-18-8
genes like me logo Genes that share compounds with HDC: view

Transcripts for HDC Gene

mRNA/cDNA for HDC Gene

Unigene Clusters for HDC Gene

Histidine decarboxylase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDC Gene

No ASD Table

Relevant External Links for HDC Gene

GeneLoc Exon Structure for
HDC
ECgene alternative splicing isoforms for
HDC

Expression for HDC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HDC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HDC Gene

This gene is overexpressed in Brain - Hypothalamus (x28.0).

Protein differential expression in normal tissues from HIPED for HDC Gene

This gene is overexpressed in Urine (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HDC Gene



Protein tissue co-expression partners for HDC Gene

NURSA nuclear receptor signaling pathways regulating expression of HDC Gene:

HDC

SOURCE GeneReport for Unigene cluster for HDC Gene:

Hs.1481
genes like me logo Genes that share expression patterns with HDC: view

No data available for mRNA Expression by UniProt/SwissProt for HDC Gene

Orthologs for HDC Gene

This gene was present in the common ancestor of animals.

Orthologs for HDC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDC 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia HDC 34 35
  • 91.39 (n)
cow
(Bos Taurus)
Mammalia HDC 34 35
  • 89.87 (n)
rat
(Rattus norvegicus)
Mammalia Hdc 34
  • 86.15 (n)
mouse
(Mus musculus)
Mammalia Hdc 34 16 35
  • 85.9 (n)
oppossum
(Monodelphis domestica)
Mammalia HDC 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HDC 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves HDC 34 35
  • 73.03 (n)
lizard
(Anolis carolinensis)
Reptilia HDC 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdc 34
  • 70.24 (n)
zebrafish
(Danio rerio)
Actinopterygii hdc 34 35
  • 66.86 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009001 34
  • 61.66 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hdc 36 34 35
  • 60.99 (n)
Ddc 36
  • 51 (a)
CG30445 36
  • 49 (a)
CG30446 36
  • 49 (a)
amd 36
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea tdc-1 36 35
  • 48 (a)
ZK829.2 36
  • 39 (a)
C05D2.3 36
  • 33 (a)
F12A10.3 36
  • 30 (a)
hdl-1 35
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
Species where no ortholog for HDC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDC Gene

ENSEMBL:
Gene Tree for HDC (if available)
TreeFam:
Gene Tree for HDC (if available)

Paralogs for HDC Gene

Paralogs for HDC Gene

(2) SIMAP similar genes for HDC Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HDC: view

Variants for HDC Gene

Sequence variations from dbSNP and Humsavar for HDC Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_036470 A colorectal cancer sample
VAR_036471 A colorectal cancer sample
rs267606861 Pathogenic 50,252,520(-) CACAG(A/G)GTCAA reference, stop-gained
rs1042447 -- 50,242,055(-) GTTCA(G/T)CAGTC utr-variant-3-prime
rs10518836 -- 50,259,658(-) GCTTT(A/C)TAAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HDC Gene

Variant ID Type Subtype PubMed ID
nsv1531 CNV insertion 18451855

Variation tolerance for HDC Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.65; 72.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HDC Gene

Human Gene Mutation Database (HGMD)
HDC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HDC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDC Gene

Disorders for HDC Gene

MalaCards: The human disease database

(9) MalaCards diseases for HDC Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gilles de la tourette syndrome
  • tourette syndrome
mast cell neoplasm
  • mast cell proliferative disease
stomach disease
  • gastric disease
systemic mastocytosis
  • corneal dystrophy, subepithelial mucinous
indolent systemic mastocytosis
  • ism
- elite association - COSMIC cancer census association via MalaCards
Search HDC in MalaCards View complete list of genes associated with diseases

Relevant External Links for HDC

Genetic Association Database (GAD)
HDC
Human Genome Epidemiology (HuGE) Navigator
HDC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HDC
genes like me logo Genes that share disorders with HDC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HDC Gene

Publications for HDC Gene

  1. HDC gene polymorphisms are associated with age at natural menopause in Caucasian women. (PMID: 16919600) Zhang F. … Deng H.W. (Biochem. Biophys. Res. Commun. 2006) 3 22 46 64
  2. Structure of the L-histidine decarboxylase gene. (PMID: 8288622) Yatsunami K. … Ichikawa A. (J. Biol. Chem. 1994) 3 4 22 64
  3. Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. (PMID: 1487235) Bruneau G. … Thibault J. (Hum. Genet. 1992) 2 3 22 64
  4. Cloning of the cDNA encoding human histidine decarboxylase from an erythroleukemia cell line and mapping of the gene locus to chromosome 15. (PMID: 1768863) Zahnow C.A. … Joseph D.R. (DNA Seq. 1991) 3 4 22 64
  5. Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase. (PMID: 22767596) Komori H. … Higuchi Y. (J. Biol. Chem. 2012) 3 4 64

Products for HDC Gene

Sources for HDC Gene

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