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Aliases for HDC Gene

Aliases for HDC Gene

  • Histidine Decarboxylase 2 3
  • EC 4.1.1.22 4 63
  • EC 4.1.1 63

External Ids for HDC Gene

Previous GeneCards Identifiers for HDC Gene

  • GC15M046091
  • GC15M043580
  • GC15M048113
  • GC15M048250
  • GC15M048321
  • GC15M050534
  • GC15M027365

Summaries for HDC Gene

Entrez Gene Summary for HDC Gene

  • This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]

GeneCards Summary for HDC Gene

HDC (Histidine Decarboxylase) is a Protein Coding gene. Diseases associated with HDC include gilles de la tourette syndrome and mastocytosis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include pyridoxal phosphate binding and histidine decarboxylase activity. An important paralog of this gene is DDC.

UniProtKB/Swiss-Prot for HDC Gene

  • Catalyzes the biosynthesis of histamine from histidine.

Gene Wiki entry for HDC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDC Gene

Genomics for HDC Gene

Genomic Location for HDC Gene

Start:
50,241,947 bp from pter
End:
50,266,026 bp from pter
Size:
24,080 bases
Orientation:
Minus strand

Genomic View for HDC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDC Gene

Proteins for HDC Gene

  • Protein details for HDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19113-DCHS_HUMAN
    Recommended name:
    Histidine decarboxylase
    Protein Accession:
    P19113
    Secondary Accessions:
    • A1L4G0
    • B7ZM01

    Protein attributes for HDC Gene

    Size:
    662 amino acids
    Molecular mass:
    74141 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for HDC Gene

    Alternative splice isoforms for HDC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDC Gene

Proteomics data for HDC Gene at MOPED

Post-translational modifications for HDC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HDC Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for HDC Gene

Gene Families for HDC Gene

Suggested Antigen Peptide Sequences for HDC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19113

UniProtKB/Swiss-Prot:

DCHS_HUMAN :
  • P19113
Family:
  • Belongs to the group II decarboxylase family.
genes like me logo Genes that share domains with HDC: view

Function for HDC Gene

Molecular function for HDC Gene

GENATLAS Biochemistry: histidine decarboxylase,brain,catalyzing the histidine synthesis
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.1 mM for histidine {ECO:0000269 PubMed:22767596}; Vmax=1880 nmol/min/mg enzyme {ECO:0000269 PubMed:22767596};
UniProtKB/Swiss-Prot CatalyticActivity: L-histidine = histamine + CO(2).
UniProtKB/Swiss-Prot Function: Catalyzes the biosynthesis of histamine from histidine.

Enzyme Numbers (IUBMB) for HDC Gene

Gene Ontology (GO) - Molecular Function for HDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004398 histidine decarboxylase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016831 carboxy-lyase activity --
GO:0030170 pyridoxal phosphate binding IEA --
genes like me logo Genes that share ontologies with HDC: view
genes like me logo Genes that share phenotypes with HDC: view

Animal Models for HDC Gene

MGI Knock Outs for HDC:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for HDC Gene

Localization for HDC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HDC Gene COMPARTMENTS Subcellular localization image for HDC gene
Compartment Confidence
cytosol 4
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HDC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HDC Gene

Pathways for HDC Gene

genes like me logo Genes that share pathways with HDC: view

Pathways by source for HDC Gene

2 KEGG pathways for HDC Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P19113-DCHS_HUMAN

  • Pathway: Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1

Gene Ontology (GO) - Biological Process for HDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001694 histamine biosynthetic process IEA --
GO:0006520 cellular amino acid metabolic process --
GO:0006547 histidine metabolic process TAS 1487235
GO:0006548 histidine catabolic process TAS --
GO:0019752 carboxylic acid metabolic process --
genes like me logo Genes that share ontologies with HDC: view

Compounds for HDC Gene

(11) HMDB Compounds for HDC Gene

Compound Synonyms Cas Number PubMed IDs
Carbon dioxide
  • Carbon oxide
124-38-9
Carnosine
  • Beta-Alanyl-L-histidine
305-84-0
Histamine
  • 1H-Imidazole-4-ethanamine
51-45-6
L-Histidine
  • (S)-1H-Imidazole-4-alanine
71-00-1
N1-Acetylspermine
  • N'-Acetylspermine
25593-72-0

(2) Drugbank Compounds for HDC Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Histidine
  • (S)-4-(2-Amino-2-carboxyethyl)imidazole
71-00-1 target
Pyridoxal Phosphate
  • Codecarboxylase
54-47-7 target cofactor

(3) IUPHAR Ligand for HDC Gene

Ligand Type Action Affinity Pubmed IDs
SAM486A Inhibitor Inhibition 8
AMA Inhibitor Inhibition
FMH Inhibitor Inhibition

(41) Novoseek inferred chemical compound relationships for HDC Gene

Compound -log(P) Hits PubMed IDs
histidine 93.6 187
histamine 90.1 177
alpha-fluoromethylhistidine 85.7 11
loxtidine 82.1 4
n,n-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 79.7 1
genes like me logo Genes that share compounds with HDC: view

Transcripts for HDC Gene

mRNA/cDNA for HDC Gene

Unigene Clusters for HDC Gene

Histidine decarboxylase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HDC

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HDC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDC Gene

No ASD Table

Relevant External Links for HDC Gene

GeneLoc Exon Structure for
HDC
ECgene alternative splicing isoforms for
HDC

Expression for HDC Gene

mRNA expression in normal human tissues for HDC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HDC Gene

This gene is overexpressed in Brain - Hypothalamus (28.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HDC Gene

SOURCE GeneReport for Unigene cluster for HDC Gene Hs.1481

genes like me logo Genes that share expressions with HDC: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HDC Gene

Orthologs for HDC Gene

This gene was present in the common ancestor of animals.

Orthologs for HDC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDC 35
  • 99.7 (n)
  • 99.55 (a)
HDC 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HDC 35
  • 89.87 (n)
  • 91.49 (a)
HDC 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HDC 35
  • 91.39 (n)
  • 92.6 (a)
HDC 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hdc 35
  • 85.9 (n)
  • 87.79 (a)
Hdc 16
Hdc 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HDC 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HDC 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hdc 35
  • 86.15 (n)
  • 87.69 (a)
chicken
(Gallus gallus)
Aves HDC 35
  • 73.03 (n)
  • 77.71 (a)
HDC 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HDC 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdc 35
  • 70.24 (n)
  • 74.07 (a)
zebrafish
(Danio rerio)
Actinopterygii hdc 35
  • 66.86 (n)
  • 68.76 (a)
hdc 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009001 35
  • 61.66 (n)
  • 62.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hdc 35
  • 60.99 (n)
  • 61.76 (a)
Hdc 36
  • 40 (a)
OneToOne
Ddc 37
  • 51 (a)
CG30446 37
  • 49 (a)
Hdc 37
  • 61 (a)
CG30445 37
  • 49 (a)
amd 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea hdl-1 36
  • 22 (a)
ManyToMany
tdc-1 36
  • 36 (a)
ManyToMany
F12A10.3 37
  • 30 (a)
ZK829.2 37
  • 39 (a)
tdc-1 37
  • 48 (a)
C05D2.3 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
Species with no ortholog for HDC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDC Gene

ENSEMBL:
Gene Tree for HDC (if available)
TreeFam:
Gene Tree for HDC (if available)

Paralogs for HDC Gene

Paralogs for HDC Gene

Selected SIMAP similar genes for HDC Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HDC: view

Variants for HDC Gene

Sequence variations from dbSNP and Humsavar for HDC Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs552379 -- 50,248,700(+) AATCT(A/T)TATTC intron-variant
rs854150 -- 50,249,962(-) GTCAG(C/G)CTTTA intron-variant
rs854151 -- 50,250,522(+) CTCCA(A/G)ACTCC intron-variant
rs854152 -- 50,251,833(+) TCTCA(A/G)AAAAA intron-variant
rs854153 -- 50,258,886(+) CCGGG(C/T)GCGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDC Gene

Variant ID Type Subtype PubMed ID
nsv483038 CNV Gain 15286789
nsv1531 CNV Insertion 18451855

Relevant External Links for HDC Gene

HapMap Linkage Disequilibrium report
HDC
Human Gene Mutation Database (HGMD)
HDC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDC Gene

Disorders for HDC Gene

(1) OMIM Diseases for HDC Gene (142704)

(2) University of Copenhagen DISEASES for HDC Gene

(32) Novoseek inferred disease relationships for HDC Gene

Disease -log(P) Hits PubMed IDs
leukemia basophilic 56.6 3
carcinoid 52.4 8
mastocytoma 47.5 9
gastric disorder 46.5 1
mastocytosis systemic 43.6 2

Relevant External Links for HDC

Genetic Association Database (GAD)
HDC
Human Genome Epidemiology (HuGE) Navigator
HDC
genes like me logo Genes that share disorders with HDC: view

No data available for UniProtKB/Swiss-Prot for HDC Gene

Publications for HDC Gene

  1. Cloning of the cDNA encoding human histidine decarboxylase from an erythroleukemia cell line and mapping of the gene locus to chromosome 15. (PMID: 1768863) Zahnow C.A. … Joseph D.R. (DNA Seq. 1991) 3 4 23
  2. Structure of the L-histidine decarboxylase gene. (PMID: 8288622) Yatsunami K. … Ichikawa A. (J. Biol. Chem. 1994) 3 4 23
  3. Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. (PMID: 1487235) Bruneau G. … Thibault J. (Hum. Genet. 1992) 2 3 23
  4. HDC gene polymorphisms are associated with age at natural menopause in Caucasian women. (PMID: 16919600) Zhang F. … Deng H.W. (Biochem. Biophys. Res. Commun. 2006) 3 23 48
  5. Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells. (PMID: 12679420) SkAPldberg F. … KAompe O. (J. Clin. Endocrinol. Metab. 2003) 3 23 25

Products for HDC Gene

Sources for HDC Gene

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