Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HDAC7 Gene

protein-coding   GIFtS: 64
GCID: GC12M048176

Histone Deacetylase 7

(Previous name: histone deacetylase 7A)
(Previous symbol: HDAC7A)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Histone Deacetylase 71 2     EC 3.5.1.983 8
HDAC7A1 2 3 5     HD7A2
Histone Deacetylase 7A1 2 3     HD7a3
HD72 3     

External Ids:    HGNC: 140671   Entrez Gene: 515642   Ensembl: ENSG000000612737   OMIM: 6065425   UniProtKB: Q8WUI43   

Export aliases for HDAC7 gene to outside databases

Previous GC identifers: GC12M046463 GC12M045207


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HDAC7 Gene:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.
Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The
protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is
orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor
SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for HDAC7 Gene:
HDAC7 (histone deacetylase 7) is a protein-coding gene. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is HDAC9.

UniProtKB/Swiss-Prot: HDAC7_HUMAN, Q8WUI4
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A,
H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in
transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the
formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte
enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm,
allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV)
latency, possibly by repressing the viral BZLF1 gene

summary for HDAC7 Gene:
Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal
of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional
repression. In general, they do not act autonomously but as components of large multiprotein complexes, such
as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of
HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously
expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by
protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the
class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the
nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to
substantial interest in HDAC inhibitors as possible antineoplastic agents.

Gene Wiki entry for HDAC7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HDAC7 gene promoter:
         Nkx2-5   c-Ets-1   E47   FAC1   PPAR-gamma1   SEF-1 (1)   PPAR-gamma2   Pax-4a   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): HDAC7 promoter sequence
   Search Chromatin IP Primers for HDAC7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HDAC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.1   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13.1

HDAC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDAC7 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M048176:  view genomic region     (about GC identifiers)

Start:
48,176,505 bp from pter      End:
48,226,915 bp from pter
Size:
50,411 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HDAC7_HUMAN, Q8WUI4 (See protein sequence)
Recommended Name: Histone deacetylase 7  
Size: 952 amino acids; 102927 Da
Subunit: Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30
and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C (By similarity). Interacts with KAT5
and EDNRA. Interacts with KDM5B. Interacts with ZMYND15 (By similarity). Interacts with PML (isoform PML-4)
Miscellaneous: Its activity is inhibited by Trichostatin A (TSA), a known histone deacetylase inhibitor (By
similarity)
Sequence caution: Sequence=AAF63491.1; Type=Frameshift; Positions=877; Sequence=BAA91474.1; Type=Erroneous
initiation; Sequence=BAA91545.1; Type=Erroneous initiation; Sequence=BAB15759.1; Type=Erroneous initiation;
Sequence=BAB55363.1; Type=Erroneous initiation; Sequence=BAC56929.1; Type=Miscellaneous discrepancy; Note=Intron
retention;
5 PDB 3D structures from and Proteopedia for HDAC7:
3C0Y (3D)        3C0Z (3D)        3C10 (3D)        3ZNR (3D)        3ZNS (3D)    
Secondary accessions: B3KY08 B4DWI0 B4E0Q5 Q6P1W9 Q6W9G7 Q7Z4K2 Q7Z5I1 Q96K01 Q9BR73 Q9H7L0
Q9NW41 Q9NWA9 Q9NYK9 Q9UFU7
Alternative splicing: 10 isoforms:  Q8WUI4-1   Q8WUI4-2   Q8WUI4-3   Q8WUI4-4   Q8WUI4-5   Q8WUI4-6   Q8WUI4-7   Q8WUI4-8   
Q8WUI4-9   Q8WUI4-10   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HDAC7: NX_Q8WUI4

Explore proteomics data for HDAC7 at MOPED

Post-translational modifications: 

  • May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import.
    Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from
    the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-1811
  • Ubiquitination2 at Lys603
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for HDAC7 (Q8WUI4) (see all 11)
     EYLAAFR  HHGNGTQ  SKILIVD  SAKCFGY 


    See HDAC7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091886.1  NP_056216.2  

    ENSEMBL proteins: 
     ENSP00000080059   ENSP00000351326   ENSP00000448305   ENSP00000446538   ENSP00000448532  
     ENSP00000449171   ENSP00000369984   ENSP00000447191   ENSP00000404394   ENSP00000448448  
     ENSP00000401872   ENSP00000396159   ENSP00000410068   ENSP00000411058   ENSP00000389501  
     ENSP00000388561   ENSP00000412155   ENSP00000397236   ENSP00000400811   ENSP00000403149  
     ENSP00000387792   ENSP00000390415  
    Reactome Protein details: Q8WUI4

    HDAC7 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant HDAC7 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for HDAC7
    OriGene Protein Over-expression Lysate for HDAC7
    OriGene MassSpec for HDAC7
    OriGene Custom Protein Services for HDAC7
    GenScript Custom Purified and Recombinant Proteins Services for HDAC7
    Novus Biologicals HDAC7 Protein
    Novus Biologicals HDAC7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HDAC7

     
    Search eBioscience for Proteins for HDAC7 

     
    antibodies-online proteins for HDAC7 (2 products) 

     
    antibodies-online peptides for HDAC7

    HDAC7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HDAC7
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for HDAC7 
    OriGene Antibodies for HDAC7
    OriGene Custom Antibody Services for HDAC7
    Novus Biologicals HDAC7 Antibodies
    Search for Antibodies for HDAC7 at Abcam
    Cloud-Clone Corp. Antibodies for HDAC7
    ThermoFisher Antibody for HDAC7
    antibodies-online antibodies for HDAC7 (156 products) 

    HDAC7 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of HDAC7
    OriGene Custom Assay Services for HDAC7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HDAC7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HDAC7
    Cloud-Clone Corp. CLIAs for HDAC7
    Search eBioscience for ELISAs for HDAC7 
    antibodies-online kits for HDAC7 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR017320 Histone_deAcase_II_euk
     IPR000286 His_deacetylse
     IPR023801 His_deacetylse_dom

    Graphical View of Domain Structure for InterPro Entry Q8WUI4

    ProtoNet protein and cluster: Q8WUI4

    1 Blocks protein domain: IPB000286 Histone deacetylase superfamily signature

    UniProtKB/Swiss-Prot: HDAC7_HUMAN, Q8WUI4
    Domain: The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm (By similarity)
    Similarity: Belongs to the histone deacetylase family. HD type 2 subfamily


    Find genes that share domains with HDAC7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HDAC7_HUMAN, Q8WUI4
    Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A,
    H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in
    transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the
    formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte
    enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm,
    allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV)
    latency, possibly by repressing the viral BZLF1 gene
    Catalytic activity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone

         Enzyme Number (IUBMB): EC 3.5.1.981 2

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0004407histone deacetylase activity ----
    GO:0005080protein kinase C binding IPI--
    GO:0005515protein binding IPI15161933
         
    Find genes that share ontologies with HDAC7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HDAC7:
     Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hdac7):
     cardiovascular system  craniofacial  embryogenesis  homeostasis/metabolism  mortality/aging 
     muscle 

    Find genes that share phenotypes with HDAC7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hdac7tm1Eno for HDAC7

       genOway: Develop your customized and physiologically relevant rodent model for HDAC7

    miRNA
    Products:
        
    miRTarBase miRNAs that target HDAC7:
    hsa-mir-615-3p (MIRT040075), hsa-mir-149-5p (MIRT045413)

    Block miRNA regulation of human, mouse, rat HDAC7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HDAC7 (see all 28):
    hsa-miR-140-5p hsa-miR-520d-5p hsa-miR-1271 hsa-miR-767-5p hsa-miR-520a-5p hsa-miR-3667-5p hsa-miR-23a hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidHDAC7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HDAC7
    Predesigned siRNA for gene silencing in human, mouse, rat HDAC7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HDAC7

    Clone
    Products:
         
    OriGene clones in human, mouse for HDAC7 (see all 16)
    OriGene ORF clones in mouse, rat for HDAC7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HDAC7 (NM_015401)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDAC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDAC7
    Addgene plasmids for HDAC7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HDAC7
    Browse ESI BIO Cell Lines and PureStem Progenitors for HDAC7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDAC7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HDAC7_HUMAN, Q8WUI4: Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like
    structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the
    nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein
    YWHAE and is due to its phosphorylation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex IEA--
    GO:0005634nucleus IDA16980613
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with HDAC7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HDAC7 About   (see all 18)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    2Immune response Function of MEF2 in T lymphocytes
    Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis0.38
    Immune response Function of MEF2 in T lymphocytes0.38
    3Cell cycle
    Cell cycle0.59
    4Signaling by GPCR
    Signal Transduction0.58
    5fMLP Pathway
    Signal transduction Activation of PKC via G Protein coupled receptor0.42


    Find genes that share SuperPaths with HDAC7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HDAC7 (see all 15)
        DNA Methylation and Transcriptional Repression
    Protein Acetylation and Deacetylation
    BRCA1 Pathway
    Glucocorticoid Receptor Signaling
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for HDAC7
        Chromatin Regulation / Acetylation

    4 GeneGo (Thomson Reuters) Pathways for HDAC7
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Signal transduction Calcium signaling

    Selected BioSystems Pathways for HDAC7 (see all 8)
        MicroRNAs in cardiomyocyte hypertrophy
    Cell cycle
    Neural Crest Differentiation
    B Cell Receptor Signaling Pathway
    Signaling events mediated by HDAC Class I

    3 Reactome Pathways for HDAC7
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    Constitutive Signaling by NOTCH1 PEST Domain Mutants


    2 Kegg Pathways  (Kegg details for HDAC7):
        Alcoholism
    Viral carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HDAC7: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HDAC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HDAC7 (Q8WUI41, 2, 3 ENSP000000800594) via UniProtKB, MINT, STRING, and/or I2D (see all 214)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319471, 2, 3, ENSP000003409894EBI-1048378,EBI-476295 MINT-3975829 MINT-8008298 I2D: score=2 STRING: ENSP00000340989
    PRKD2Q9BZL61, 2, 3, ENSP000002912814EBI-1048378,EBI-1384325 MINT-6177460 MINT-6177495 MINT-6177477 MINT-6177512 MINT-6177440 MINT-6177417 I2D: score=3 STRING: ENSP00000291281
    YWHAZP631041, 2, 3, ENSP000003095034EBI-1048378,EBI-347088 MINT-3296507 MINT-8009847 I2D: score=2 STRING: ENSP00000309503
    YWHAGP619812, 3, ENSP000003063304MINT-50889 I2D: score=4 STRING: ENSP00000306330
    CASP8Q147903, ENSP000003512734I2D: score=2 STRING: ENSP00000351273
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001570vasculogenesis IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007043cell-cell junction assembly IEA--
    GO:0007219Notch signaling pathway TAS--

    Find genes that share ontologies with HDAC7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for HDAC7 (see all 29)     About this table
    CompoundAction CAS #
    AR-42 (OSU-HDAC42)Pan-HDAC inhibitor[935881-37-1]
    Belinostat (PXD101)Novel and potent hydroxamate-type HDAC inhibitor[414864-00-9]
    CI994 (Tacedinaline)HDAC1 and 3 inhibitor[112522-64-2]
    CUDC-101Multitargeted HDAC inhibitor[1012054-59-9]
    CUDC-907PI3K and HDAC inhibitor[1339928-25-4]
    DroxinostatSelective HDAC inhibitor[99873-43-5]
    Entinostat (MS-275,SNDX-275)Entinostat inhibits HDAC1 and HDAC3 but not HDAC8[209783-80-2]
    ITF2357 (Givinostat)HDAC inhibitor, inhibits class I and class II HDACs[732302-99-7]
    JNJ-26481585Potent pan-HDAC inhibitor[875320-29-9]
    LAQ824 (NVP-LAQ824,Dacinostat)Novel and potent HDAC inhibitor[404951-53-7]

    Compounds for HDAC7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TCS HDAC6 20bSelective HDAC6 inhibitor[956154-63-5]
    LMK 235Selective HDAC4/HDAC5 inhibitor[1418033-25-6]
    Trichostatin AHistone deacetylase inhibitor[58880-19-6]
    TubacinHDAC6 inhibitor; inhibits alpha-tubulin deacetylation[1350555-93-9]
    Sodium 4-PhenylbutyrateHistone deacetylase inhibitor[1716-12-7]

    1 DrugBank Compound for HDAC7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide-- --target--10592235

    2 Novoseek inferred chemical compound relationships for HDAC7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 40.9 5 15738054 (1), 11585834 (1), 18509061 (1), 17369396 (1)
    threonine 38.6 1 17369396 (1)



    Find genes that share compounds with HDAC7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HDAC7 gene (3 alternative transcripts): 
    NM_001098416.2  NM_015401.3  NM_016596.3  

    Unigene Cluster for HDAC7:

    Histone deacetylase 7
    Hs.200063  [show with all ESTs]
    Unigene Representative Sequence: AK024387
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000080059(uc010slo.2 uc001rqk.4) ENST00000354334(uc001rqj.4)
    ENST00000459625 ENST00000548938 ENST00000470668(uc001rqe.3) ENST00000548080
    ENST00000549883 ENST00000552960 ENST00000477203(uc009zkv.1) ENST00000380610
    ENST00000547259 ENST00000427332 ENST00000471235(uc010slp.2) ENST00000488927
    ENST00000477937 ENST00000491464 ENST00000463732 ENST00000485796
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HDAC7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HDAC7 (see all 28):
    hsa-miR-140-5p hsa-miR-520d-5p hsa-miR-1271 hsa-miR-767-5p hsa-miR-520a-5p hsa-miR-3667-5p hsa-miR-23a hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidHDAC7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HDAC7
    Predesigned siRNA for gene silencing in human, mouse, rat HDAC7
    Clone
    Products:
         
    OriGene clones in human, mouse for HDAC7 (see all 16)
    OriGene ORF clones in mouse, rat for HDAC7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HDAC7 (NM_015401)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDAC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDAC7
    Addgene plasmids for HDAC7 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HDAC7
    OriGene qSTAR qPCR primer pairs in human, mouse for HDAC7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HDAC7
      QuantiTect SYBR Green Assays in human, mouse, rat HDAC7
      QuantiFast Probe-based Assays in human, mouse, rat HDAC7

    Additional mRNA sequence: 

    AF239243.1 AK001032.1 AK001190.1 AK024387.1 AK024469.1 AK026767.1 AK027781.1 AK128383.1 
    AK225910.1 AK299292.1 AK301545.1 AK303481.1 AL117455.1 AY302468.1 AY321367.1 BC006453.1 
    BC020505.2 BC064840.1 BT009771.1 

    Selected DOTS entries (see all 27):

    DT.448891  DT.99970821  DT.100030327  DT.101968383  DT.100786379  DT.101942  DT.100786380  DT.105986 
    DT.121171782  DT.121171818  DT.121171793  DT.100030324  DT.101984697  DT.425691  DT.95116197  DT.121171896 
    DT.121171918  DT.75195228  DT.86847362  DT.91763871  DT.91763874  DT.100030325  DT.100699144  DT.121171922 

    Selected AceView cDNA sequences (see all 345):

    AK122588 BQ955966 BM836794 BX105995 AI220029 NM_016596 BP369139 BI491988 
    AY302468 CF141891 AA835730 T82325 BE612861 BE315413 AL040933 CB131336 
    BE887728 BM678911 BM553240 AA431174 BC020505 AI221200 CR615119 BI041919 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HDAC7 (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a ·
    SP1:                                                                                                                                                        -   
    SP2:                                                  -     -     -     -                                                                             -     -   
    SP3:                                                  -     -     -     -                                   -     -                                             
    SP4:                                                                                                                                                            
    SP5:                    -     -     -     -     -     -     -     -     -                                                                                       

    ExUns: 16b · 16c ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32 ^ 33a ·
    SP1:                                                  -     -                                                                             -           -     -   
    SP2:                                                  -     -                                                                             -           -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 33b ^ 34a · 34b · 34c · 34d
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for HDAC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HDAC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTGTAAA
    HDAC7 Expression
    About this image

    HDAC7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HDAC7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.200063
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HDAC7: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HDAC7
    OriGene qSTAR qPCR primer pairs in human, mouse for HDAC7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HDAC7
    QuantiTect SYBR Green Assays in human, mouse, rat HDAC7
    QuantiFast Probe-based Assays in human, mouse, rat HDAC7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDAC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HDAC7 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hdac71 , 5 histone deacetylase 71, 5 87.08(n)1
    90.31(a)1
      15 (53.79 cM)5
    562331  NM_001204277.11  NP_001191206.11 
     977926645 
    chicken
    (Gallus gallus)
    Aves HDAC71 histone deacetylase 7 70.04(n)
    69.16(a)
      426885  NM_001031402.1  NP_001026573.1 
    lizard
    (Anolis carolinensis)
    Reptilia HDAC76
    histone deacetylase 7
    65(a)
    1 ↔ 1
    GL343252.1(1497040-1770592)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hdac71 histone deacetylase 7 63.57(n)
    61.61(a)
      100158627  XM_002935655.2  XP_002935701.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7986031 histone deacetylase 4-like 67.94(n)
    66.51(a)
      798603  XM_001339008.5  XP_001339044.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta HDAC46
    HDAC4
    28(a)
    1 → many
    X(13156720-13179354)
    worm
    (Caenorhabditis elegans)
    Secernentea hda-46
    Protein HDA-4, isoform a
    31(a)
    1 → many
    X(16729559-16744698) WBGene00001837
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HDA16
    Putative catalytic subunit of a class II histone d...
    8(a)
    1 → many
    XIV(593227-595347) YNL021W


    ENSEMBL Gene Tree for HDAC7 (if available)
    TreeFam Gene Tree for HDAC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HDAC7 gene
    HDAC92  HDAC62  HDAC52  HDAC42  HDAC102  
    8 SIMAP similar genes for HDAC7 using alignment to 19 protein entries:     HDAC7_HUMAN (see all proteins):
    KIAA0600    HDAC4    MGC16025    HDAC9    HDAC5    DKFZp566E044
    HDAC6    DKFZp779K1053

    Find genes that share paralogs with HDAC7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HDAC7 (see all 917)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360434
    A breast cancer sample4--see VAR_0360432 V M mis40--------
    rs771903231,2
    C,F--48177043(+) AGTCTC/TGGCTG 2 -- ut311Minor allele frequency- T:0.03NA 120
    rs731079271,2
    C,F--48177046(+) CTCGGC/TTGTCA 2 -- ut311Minor allele frequency- T:0.05NA 120
    rs24088741,2
    C,F,A,H--48177073(+) TGCCCA/C/G/
            
    GTGGT
    6 -- ut31 ese316NA EA WA CSA 741
    rs1850817531,2
    --48177114(+) GCAGGC/TGAGAG 2 -- ut310--------
    rs7573421,2
    C,F,A--48177170(-) GCTAGG/CGGGGA 2 -- ut31 ese38Minor allele frequency- C:0.17MN NA WA EA 554
    rs570613631,2
    C--48177224(+) CATTTC/TTGTGT 2 -- ut312Minor allele frequency- T:0.04WA 120
    rs1388145371,2
    --48177228(+) TCTGTG/TTGGAG 2 -- ut310--------
    rs136321,2
    C,F,A,H--48177238(-) CAGCCC/TCAGGC 2 -- ut31 ese332Minor allele frequency- A:0.00MN EA NA NS WA CSA 4374
    rs1404688021,2
    --48177249(+) TGTGCA/CAAGTC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HDAC7 (48176505 - 48226915 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HDAC7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv999028CNV Deletion20482838
    dgv94n21CNV Loss19592680
    nsv899060CNV Loss21882294
    nsv899059CNV Loss21882294
    nsv470289CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HDAC7
    DNA2.0 Custom Variant and Variant Library Synthesis for HDAC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606542    OMIM disorders: --


    Find genes that share disorders with HDAC7           About GenesLikeMe

    1 Novoseek inferred disease relationship for HDAC7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiac hypertrophy 29.6 1 17038545 (1)

    Genetic Association Database (GAD): HDAC7
    Human Genome Epidemiology (HuGE) Navigator: HDAC7 (12 documents)

    Export disorders for HDAC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HDAC7 gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with HDAC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. (PubMed id 11466315)1, 2, 9 Fischle W....Verdin E. (J. Biol. Chem. 2001)
    2. Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. (PubMed id 17962809)1, 2, 9 von Blume J.... Seufferlein T. (EMBO J. 2007)
    3. Beta-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells. (PubMed id 22155184)1, 2 Satow R.... Yamada T. (Gastroenterology 2012)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    6. Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. (PubMed id 18285338)1, 2 Schuetz A....Arrowsmith C.H. (J. Biol. Chem. 2008)
    7. Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. (PubMed id 17373667)1, 2 Barrett A.... Taylor-Papadimitriou J. (Int. J. Cancer 2007)
    8. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. (PubMed id 16980613)1, 2 Dequiedt F.... Kettmann R. (Mol. Cell. Biol. 2006)
    9. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51564 HGNC: 14067 AceView: HDAC7A Ensembl:ENSG00000061273 euGenes: HUgn51564
    ECgene: HDAC7 Kegg: 51564 H-InvDB: HDAC7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HDAC7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HDAC7 gene:
    Search GeneIP for patents involving HDAC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Purified and/or Recombinant HDAC7 Protein
     Browse Small Molecules at EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of HDAC7
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HDAC7
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HDAC7   OriGene RNAi products in human, mouse, rat for HDAC7  
     OriGene qPCR primer pairs and template standards for HDAC7   OriGene Protein Over-expression Lysate for HDAC7  
     OriGene MassSpec for HDAC7   OriGene clones in human, mouse for HDAC7  
     OriGene qSTAR qPCR primer pairs in human, mouse for HDAC7   OriGene Purified Protein for HDAC7  
     OriGene ORF clones in mouse, rat for HDAC7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HDAC7   OriGene Custom Protein Services for HDAC7  

     
     
     Block miRNA regulation of human, mouse, rat HDAC7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HDAC7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HDAC7 Predesigned siRNA for gene silencing in human, mouse, rat HDAC7
     QuantiFast Probe-based Assays in human, mouse, rat HDAC7 QuantiTect SYBR Green Assays in human, mouse, rat HDAC7
     PCR Arrays including human, mouse, rat HDAC7 Search Chromatin IP Primers for HDAC7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HDAC7  GeneGlobe Interaction Network for HDAC7
     Regulatory tfbs in HDAC7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HDAC7 GenScript cDNA clones with any tag delivered in your preferred vector for HDAC7
     GenScript Custom Assay Services for HDAC7 GenScript Custom overexpressing Cell Line Services for HDAC7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for HDAC7 

     Tocris compounds for HDAC7
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HDAC7 antibodies
     HDAC7 proteins
     HDAC7 lysates
     Search for Antibodies for HDAC7 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HDAC7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HDAC7
     Antibodies for HDAC7
     ELISAs for HDAC7
     CLIAs for HDAC7



     Browse ESI BIO Cell Lines and PureStem Progenitors for HDAC7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDAC7
     SwitchGear 3'UTR luciferase reporter plasmids for HDAC7
     SwitchGear Promoter luciferase reporter plasmids for HDAC7
     ThermoFisher Antibody for HDAC7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDAC7
     ApexBio compounds for HDAC7
     Addgene plasmids for HDAC7
      Search eBioscience for proteins for HDAC7
      Search eBioscience for elisas for HDAC7
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HDAC7
     antibodies-online antibodies for HDAC7 (156 products)
     antibodies-online kits for HDAC7 (8 products)
     antibodies-online peptides for HDAC7
     antibodies-online proteins for HDAC7 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HDAC7 gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4