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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HDAC7 Gene

protein-coding   GIFtS: 61
GCID: GC12M048176

histone deacetylase 7

(Previous name: histone deacetylase 7A )
(Previous symbol: HDAC7A)
 Explore 13 diseases affiliated with
HDAC7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HDAC7    

Aliases
for HDAC7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Deacetylase 71 2     EC 3.5.1.983 8
HDAC7A1 2 3 5     DKFZP586J09171
Histone Deacetylase 7A1 2 3     HD7A2
HD72 3     HD7a3

External Ids:    HGNC: 140671   Entrez Gene: 515642   Ensembl: ENSG000000612737   OMIM: 6065425   UniProtKB: Q8WUI43   

Export aliases for HDAC7 gene to outside databases

Previous GC identifers: GC12M046463 GC12M045207


Summaries
for HDAC7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HDAC7:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone
acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein
encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to
mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively
spliced transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HDAC7_HUMAN, Q8WUI4
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B,
H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional
regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large
multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as
MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of
myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing
the viral BZLF1 gene

summary for HDAC7:
Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal
of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional
repression. In general, they do not act autonomously but as components of large multiprotein complexes, such
as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of
HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously
expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by
protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the
class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the
nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to
substantial interest in HDAC inhibitors as possible antineoplastic agents.

Gene Wiki entry for HDAC7


Genomic Views
for HDAC7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HDAC7 gene promoter:
         Nkx2-5   c-Ets-1   E47   FAC1   PPAR-gamma1   SEF-1 (1)   PPAR-gamma2   Pax-4a   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): HDAC7 promoter sequence
   Search SABiosciences Chromatin IP Primers for HDAC7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDAC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.1   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13.1

HDAC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDAC7 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M048176:  view genomic region     (about GC identifiers)

Start:
 48,176,505 bp from pter      End:
 48,226,915 bp from pter
Size:
 50,411 bases      Orientation:
 minus strand

Proteins
for HDAC7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HDAC7_HUMAN, Q8WUI4 (See protein sequence)
Recommended Name: Histone deacetylase 7  
Size: 952 amino acids; 102927 Da
Subunit: Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and
MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C (By similarity). Interacts with KAT5 and EDNRA.
Interacts with KDM5B. Interacts with ZMYND15 (By similarity)
Subcellular location: Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like
structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus
to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due
to its phosphorylation
Miscellaneous: Its activity is inhibited by Trichostatin A (TSA), a known histone deacetylase inhibitor (By similarity)
Sequence caution: Sequence=AAF63491.1; Type=Frameshift; Positions=877; Sequence=BAA91474.1; Type=Erroneous initiation;
Sequence=BAA91545.1; Type=Erroneous initiation; Sequence=BAB15759.1; Type=Erroneous initiation; Sequence=BAB55363.1;
Type=Erroneous initiation; Sequence=BAC56929.1; Type=Miscellaneous discrepancy; Note=Intron retention;
3 PDB 3D structures from and Proteopedia for HDAC7:
3C0Y (3D)        3C0Z (3D)        3C10 (3D)    
Secondary accessions: B3KY08 B4DWI0 B4E0Q5 Q6P1W9 Q6W9G7 Q7Z4K2 Q7Z5I1 Q96K01 Q9BR73 Q9H7L0 Q9NW41
Q9NWA9 Q9NYK9 Q9UFU7
Alternative splicing: 10 isoforms:  Q8WUI4-1   Q8WUI4-2   Q8WUI4-3   Q8WUI4-4   Q8WUI4-5   Q8WUI4-6   Q8WUI4-7   Q8WUI4-8   
Q8WUI4-9   Q8WUI4-10   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HDAC7: NX_Q8WUI4

Post-translational modifications:

  • May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import.
    • Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the
    nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-1811
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WUI4

    • 4/11 DME Specific Peptides for HDAC7 (Q8WUI4) (see all 11)
     EYLAAFR  HHGNGTQ  SKILIVD  SAKCFGY 

    HDAC7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091886.1  NP_056216.2  

    ENSEMBL proteins: 
     ENSP00000080059   ENSP00000351326   ENSP00000448305   ENSP00000446538   ENSP00000449193  
     ENSP00000448532   ENSP00000449171   ENSP00000369984   ENSP00000447191   ENSP00000404394  
     ENSP00000448448   ENSP00000401872   ENSP00000396159   ENSP00000410068   ENSP00000411058  
     ENSP00000389501   ENSP00000388561   ENSP00000412155   ENSP00000397236   ENSP00000400811  
     ENSP00000403149   ENSP00000387792   ENSP00000390415  
    Reactome Protein details: Q8WUI4
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant HDAC7 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HDAC7
    OriGene Protein Over-expression Lysate: HDAC7
    OriGene Custom Protein Services for HDAC7 
    GenScript Custom Purified and Recombinant Proteins Services for HDAC7
    Novus Biologicals HDAC7 Protein
    Novus Biologicals HDAC7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HDAC7

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex IEA--
    GO:0005634nucleus IDA16980613
    GO:0005737cytoplasm IDA--


    HDAC7 for ontologies           About GeneDecksing



    HDAC7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HDAC7
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for HDAC7 
    OriGene Antibodies (see all 2): HDAC7
    OriGene Custom Antibody Services for HDAC7 
    GenScript Custom Superior Antibodies Services for HDAC7
    Novus Biologicals HDAC7 Antibodies
    Abcam antibodies for HDAC7 
    Uscn Antibodies for HDAC7
    ThermoFisher Antibodies for HDAC7

    Assay Products for HDAC7: 
    EMD Millipore Kits and Assays for the Analysis of HDAC7
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HDAC7
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HDAC7

    Protein Domains /
    Families
    for HDAC7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HDAC7 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017320 Histone_deAcase_II_euk
     IPR000286 His_deacetylse
     IPR023801 His_deacetylse_dom

    Graphical View of Domain Structure for InterPro Entry Q8WUI4

    ProtoNet protein and cluster: Q8WUI4

    1 Blocks protein family: IPB000286 Histone deacetylase superfamily signature

    UniProtKB/Swiss-Prot: HDAC7_HUMAN, Q8WUI4
    Domain: The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm (By similarity)
    Similarity: Belongs to the histone deacetylase family. HD type 2 subfamily


    Function
    for HDAC7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HDAC7_HUMAN, Q8WUI4
    Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B,
    H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional
    regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large
    multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as
    MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of
    myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing
    the viral BZLF1 gene
    Catalytic activity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone

    Enzyme Number (IUBMB): EC 3.5.1.981 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): HDAC7
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HDAC7
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate HDAC7 (see all 28):
    hsa-miR-140-5p hsa-miR-520d-5p hsa-miR-1271 hsa-miR-767-5p hsa-miR-520a-5p hsa-miR-3667-5p hsa-miR-23a hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmid: HDAC7 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDAC7
    OriGene shRNA RFP: HDAC7
    OriGene siRNA: HDAC7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDAC7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HDAC7

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDAC7 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDAC7 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HDAC7 (NM_015401)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDAC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDAC7 

    Cell Line
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    Search LifeMap BioReagents cell lines for HDAC7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDAC7

    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005080protein kinase C binding IPI--
    GO:0005515protein binding ----
    GO:0019901protein kinase binding IPI16980613


    HDAC7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HDAC7:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Hdac7tm1Eno for HDAC7
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hdac7):
     cardiovascular system  craniofacial  embryogenesis  homeostasis/metabolism  mortality/aging 
     muscle 

    HDAC7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HDAC7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    8/11 pathways (see all 11)
    		Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    		Signaling by NOTCH11.00
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    		Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    		Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH0.77
    		Signaling by NOTCH1 in Cancer1.00
    		Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.71
    2Immune response_Function of MEF2 in T lymphocytes
    		Immune response_Function of MEF2 in T lymphocytes1.00
    		Immune response Function of MEF2 in T lymphocytes0.90
    3Signal transduction_Activation of PKC via G-Protein coupled receptor
    		Signal transduction_Activation of PKC via G-Protein coupled receptor1.00
    		Signal transduction Activation of PKC via G-Protein coupled receptor0.98
    4Signal transduction Calcium signaling
    		Signal transduction Calcium signaling1.00
    		Signal transduction_Calcium signaling0.97
    5Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    		Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis1.00
    		Development_Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis0.97

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for HDAC7
        Signal transduction Calcium signaling
    Immune response Function of MEF2 in T lymphocytes
    Histone modification
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Signal transduction Activation of PKC via G-Protein coupled receptor


    1 Cell Signaling Technology (CST) Pathway for HDAC7
        Chromatin Regulation / Acetylation

    4 GeneGo (Thomson Reuters) Pathways for HDAC7
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Signal transduction Calcium signaling

    5/8 BioSystems Pathways for HDAC7 (see all 8) 
        Cell cycle
    Neural Crest Differentiation
    MicroRNAs in cardiomyocyte hypertrophy
    B Cell Receptor Signaling Pathway
    Signaling events mediated by HDAC Class II

    5/13        Reactome Pathways for HDAC7 (see all 13)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    Signaling by NOTCH
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer



    HDAC7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HDAC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/156 Interacting proteins for HDAC7 (Q8WUI42, 3 ENSP000000800594) via UniProtKB, MINT, STRING, and/or I2D (see all 156)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3, ENSP000003409894MINT-3975829 MINT-8008298 I2D: score=2 STRING: ENSP00000340989
    PRKD2Q9BZL62, 3, ENSP000002912814MINT-6177460 MINT-6177495 MINT-6177477 MINT-6177512 MINT-6177440 MINT-6177417 I2D: score=3 STRING: ENSP00000291281
    YWHAZP631042, 3, ENSP000003095034MINT-3296507 MINT-8009847 I2D: score=2 STRING: ENSP00000309503
    YWHAGP619812, 3, ENSP000003063304MINT-50889 I2D: score=4 STRING: ENSP00000306330
    CASP8Q147903, ENSP000003512734I2D: score=2 STRING: ENSP00000351273
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001570vasculogenesis IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007043cell-cell junction assembly IEA--
    GO:0007219Notch signaling pathway TAS--


    HDAC7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HDAC7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HDAC7 for compounds           About GeneDecksing

    EMD Millipore small molecules for HDAC7:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HDAC7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NCH 51Histone deacetylase inhibitor[848354-66-5]
    MC 1568Selectively inhibits HDAC class II (Iia)[852475-26-4]
    Trichostatin AHistone deacetylase inhibitor[58880-19-6]
    KD 5170Histone deacetylase inhibitor[940943-37-3]
    Sodium 4-PhenylbutyrateHistone deacetylase inhibitor[1716-12-7]

    1 DrugBank Compound for HDAC7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide-- --target--10592235

    2 Novoseek chemical compound relationships for HDAC7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 40.9 5 15738054 (1), 11585834 (1), 18509061 (1), 17369396 (1)
    threonine 38.6 1 17369396 (1)

    Search CenterWatch for drugs/clinical trials and news about HDAC7 

    Transcripts
    for HDAC7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HDAC7 gene (3 alternative transcripts): 
    NM_001098416.2  NM_015401.3  NM_016596.3  

    Unigene Cluster for HDAC7:

    Histone deacetylase 7
    Hs.200063  [show with all ESTs]
    Unigene Representative Sequence: AK024387
    18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000080059(uc010slo.2 uc001rqk.4) ENST00000354334(uc001rqj.4)
    ENST00000459625 ENST00000548938 ENST00000470668(uc001rqe.3) ENST00000548080
    ENST00000551602 ENST00000549883 ENST00000552960 ENST00000477203(uc009zkv.1)
    ENST00000380610 ENST00000547259 ENST00000427332 ENST00000471235(uc010slp.2)
    ENST00000488927 ENST00000477937 ENST00000491464 ENST00000463732

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HDAC7
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate HDAC7 (see all 28):
    hsa-miR-140-5p hsa-miR-520d-5p hsa-miR-1271 hsa-miR-767-5p hsa-miR-520a-5p hsa-miR-3667-5p hsa-miR-23a hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmid: HDAC7 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDAC7
    OriGene shRNA RFP: HDAC7
    OriGene siRNA: HDAC7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDAC7
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDAC7 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDAC7 (see all 4)
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    GenScript: all cDNA clones in your preferred vector (see all 2): HDAC7 (NM_015401)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDAC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDAC7 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HDAC7
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDAC7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDAC7

    Additional cDNA sequence: 

    AF239243.1 AK001032.1 AK001190.1 AK024387.1 AK024469.1 AK026767.1 AK027781.1 AK128383.1 
    AK225910.1 AK299292.1 AK301545.1 AK303481.1 AL117455.1 AY302468.1 AY321367.1 BC006453.1 
    BC020505.2 BC064840.1 BT009771.1 

    24/27 DOTS entries (see all 27):

    DT.448891  DT.99970821  DT.100030327  DT.101968383  DT.100786379  DT.101942  DT.100786380  DT.105986 
    DT.121171782  DT.121171818  DT.121171793  DT.100030324  DT.101984697  DT.425691  DT.95116197  DT.121171896 
    DT.121171918  DT.75195228  DT.86847362  DT.91763871  DT.91763874  DT.100030325  DT.100699144  DT.121171922 

    24/345 AceView cDNA sequences (see all 345):

    BP369139 AL040933 AI097401 T82325 BE612861 BG546711 AI220029 BM553240 
    NM_016596 AY302468 BU623531 BE887728 BQ932051 BM836794 AW572297 BI041919 
    AA910294 BE315413 BQ953576 BM553308 BC020505 BQ955966 BM678911 BU148447 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for HDAC7 (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a ·
    SP1:                                                                                                                                                        -   
    SP2:                                                  -     -     -     -                                                                             -     -   
    SP3:                                                  -     -     -     -                                   -     -                                             
    SP4:                                                                                                                                                            
    SP5:                    -     -     -     -     -     -     -     -     -                                                                                       

    ExUns: 16b · 16c ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32 ^ 33a ·
    SP1:                                                  -     -                                                                             -           -     -   
    SP2:                                                  -     -                                                                             -           -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 33b ^ 34a · 34b · 34c · 34d
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for HDAC7

    Expression
    for HDAC7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HDAC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTTGTAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HDAC7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HDAC7

    SOURCE GeneReport for Unigene cluster: Hs.200063
        SABiosciences Expression via Pathway-Focused PCR Arrays including HDAC7: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for HDAC7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HDAC7 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HDAC71 histone deacetylase 7 70.89(n)
    69.93(a)    		   426885  NM_001031402.1  NP_001026573.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HDAC76
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL343252.1(1501540-1561299)
    zebrafish
    (Danio rerio)    		 Actinopterygii hdac9b6
    CABZ01074076.16
    (see all 3)    		 --
    		 8(a)
    72(a)
    (see all 3)    		 possible ortholog
    1 ↔ many
    (see all 3)    		 16(21928132-22060093)
    23(85116-91275)
    fruit fly
    (Drosophila melanogaster)    		 Insecta HDAC46
    		 HDAC4
    		 28(a)
    		 1 → many
    		 X(13156720-13179354)
    worm
    (Caenorhabditis elegans)    		 Secernentea hda-46
    		 Histone deacetylase 4
    		 28(a)
    		 1 → many
    		 X(16729486-16743726)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons hda146
    HDA086
    		 histone deacetylase 8
    		 24(a)
    21(a)
    		 possible ortholog
    possible ortholog
    		 4(16102595-16105493)
    1(2672451-2674628)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 histone deacetylase, putative, expressed
    (see all 3)    		 23(a)
    17(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 12(4192936-4197866)
    5(21504723-21509253)


    ENSEMBL Gene Tree for HDAC7 (if available)
    TreeFam Gene Tree for HDAC7 (if available) 

    Paralogs
    for HDAC7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HDAC7 gene
    HDAC92  HDAC62  HDAC52  HDAC42  HDAC102  
    8 SIMAP similar genes for HDAC7 using alignment to 20 protein entries:     HDAC7_HUMAN (see all proteins):
    KIAA0600    MGC16025    HDAC4    HDAC5    HDAC9    DKFZp566E044
    HDAC6    DKFZp779K1053

    HDAC7 for paralogs           About GeneDecksing



    Genomic Variants
    for HDAC7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/722 NCBI SNPs in HDAC7 are shown (see all 722)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs116088041,2
    		C,H,--48176102(+) CAGAAG/AACGAT 3 -- ut31 ds50014Minor allele frequency- A:0.10NA WA EA 360
    rs1883397321,2
    		--48176105(+) AAGACA/GATTTG 3 -- ut31 ds50010--------
    rs1489027711,2
    		--48176117(+) CTTACC/TTGAGC 3 -- ds5001 ut310--------
    rs1932010571,2
    		--48176130(+) CCAGCG/TGGGAC 3 -- ut31 ds50010--------
    rs1852086701,2
    		--48176141(+) TTAAAC/TCCAGG 3 -- ds5001 ut310--------
    rs1877592031,2
    		--48176169(+) TCTTCA/GGGGAT 3 -- ut31 ds50010--------
    rs1925899681,2
    		--48176178(+) ATGCCA/GTGGTG 3 -- ds5001 ut310--------
    rs1142164341,2
    		F,--48176321(+) CCAGGG/TTGTGT 3 -- ut31 ds50011Minor allele frequency- T:0.03WA 118
    rs1435667381,2
    		--48176406(+) TCCTCC/TGGCAG 3 -- ut31 ds50010--------
    rs1171932881,2
    		F,--48176454(+) CTGCAC/TACCCG 3 -- ut31 ds50011Minor allele frequency- T:0.02EA 120

    HapMap Linkage Disequilibrium report for HDAC7 (48176505 - 48226915 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HDAC7: --

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    Disorders / Diseases
    for HDAC7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HDAC7 for disorders           About GeneDecksing

    OMIM gene information: 606542    OMIM disorders: --

    13 diseases for HDAC7:    About MalaCards
    chronic lymphocytic leukemia    lymphocytic leukemia    cutaneous t cell lymphoma    cystic fibrosis
    fibrosis    osteoarthritis    leukemia    breast cancer
    hypoxia    adenocarcinoma    malaria    neuronitis
    carcinoma

    1 Novoseek disease relationship for HDAC7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiac hypertrophy 29.6 1 17038545 (1)

    Human Genome Epidemiology (HuGE) Navigator: HDAC7 (12 documents)

    Export disorders for HDAC7 gene to outside databases

    Publications
    for HDAC7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HDAC7 gene, integrated from 9 sources (see all 98):
    (articles sorted by number of sources associating them with HDAC7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. (PubMed id 11466315)1, 2, 9 Fischle W....Verdin E. (2001)
    2. Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. (PubMed id 17962809)1, 2, 9 von Blume J....Seufferlein T. (2007)
    3. Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. (PubMed id 18285338)1, 2 Schuetz A....Arrowsmith C.H. (2008)
    4. Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. (PubMed id 17373667)1, 2 Barrett A.... Taylor-Papadimitriou J. (2007)
    5. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. (PubMed id 16980613)1, 2 Dequiedt F....Kettmann R. (2006)
    6. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Tip60 is a co-repressor for STAT3. (PubMed id 12551922)1, 2 Xiao H.... Yang Y.-C. (2003)
    10. Signal transduction and transcription factor modification during reactivation of Epstein-Barr virus from latency. (PubMed id 12239305)1, 2 Bryant H. and Farrell P.J. (2002)

    External Searches for HDAC7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HDAC7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51564 HGNC: 14067 AceView: HDAC7A Ensembl:ENSG00000061273 euGenes: HUgn51564
    ECgene: HDAC7 H-InvDB: HDAC7

    Other Databases showing HDAC7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HDAC7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HDAC7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HDAC7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HDAC7 gene:
    Search GeneIP for patents involving HDAC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HDAC7 gene

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    About This Section

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