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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HDAC6 Gene

protein-coding GIFtS: 69
GCID: GC0XP048659

histone deacetylase 6

Explore 41 diseases affiliated with
HDAC6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Histone Deacetylase 6¹ ²
HD6¹ ² ³
KIAA0901¹ ³
EC 3.5.1.98³ ⁸
FLJ16239¹
JM21¹

External Ids:	HGNC: 14064¹	Entrez Gene: 10013²	Ensembl: ENSG00000094631⁷	OMIM: 300272⁵	UniProtKB: Q9UBN7³

Export aliases for HDAC6 gene to outside databases

Previous GC identifers: GC0XP047463 GC0XP046921 GC0XP047706 GC0XP048416 GC0XP048545 GC0XP046319

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HDAC6:

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone

acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein

encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal

duplication of two catalytic domains which appear to function independently of each other. This protein possesses

histone deacetylase activity and represses transcription. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HDAC6_HUMAN, Q9UBN7

Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B,

H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional

regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large

multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation

of tubulin

Function: In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins:

when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the

ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called

aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the

aggresome, facilitating their clearance by autophagy

summary for HDAC6:

Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal

of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional

repression. In general, they do not act autonomously but as components of large multiprotein complexes, such

as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of

HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously

expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by

protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the

class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the

nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to

substantial interest in HDAC inhibitors as possible antineoplastic agents.

Gene Wiki entry for HDAC6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_079573.4

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HDAC6 gene promoter:
AML1a p300
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): HDAC6 promoter sequence

Search SABiosciences Chromatin IP Primers for HDAC6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDAC6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23

HDAC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDAC6 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP048659: view genomic region (about GC identifiers)

Start:	48,659,784 bp from pter	End:	48,683,392 bp from pter
Size:	23,609 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HDAC6_HUMAN, Q9UBN7 (See protein sequence)

Recommended Name: Histone deacetylase 6

Size: 1215 amino acids; 131419 Da

Cofactor: Binds 3 zinc ions per subunit

Subunit: Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome

impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts

with CYLD. Interacts with ZMYND15 (By similarity). Interacts with DDIT3/CHOP

Subcellular location: Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules

Sequence caution: Sequence=BAA74924.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

3 PDB 3D structures from and Proteopedia for HDAC6:

3C5K (3D)

3GV4 (3D)

3PHD (3D)

Secondary accessions: O94975 Q6NT75 Q7L3E5 Q96CY0

Alternative splicing: 2 isoforms: Q9UBN7-1 Q9UBN7-2 (Required for TGF-beta1-activated gene expression associated with epithelial-mesenchymal transition (EMT) in A549 cells)

Explore the universe of human proteins at neXtProt for HDAC6: NX_Q9UBN7

Post-translational modifications:

Phosphorylated by AURKA¹

Ubiquitinated. Its polyubiquitination however does not lead to its degradation¹

Sumoylated in vitro¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UBN7

4/5 DME Specific Peptides for HDAC6 (Q9UBN7) (see all 5)

LEGGYNL

LMGLAGG

HHGNGTQ

VDWDVHHG

HDAC6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006035.2

ENSEMBL proteins:

ENSP00000392815 ENSP00000403370 ENSP00000365831 ENSP00000365795 ENSP00000334061

ENSP00000365804 ENSP00000393916 ENSP00000402189 ENSP00000402751 ENSP00000394377

ENSP00000397697 ENSP00000398566 ENSP00000398801

Reactome Protein details: Q9UBN7
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for HDAC6
	OriGene Purified Protein: HDAC6 OriGene Protein Over-expression Lysate: HDAC6 OriGene Custom Protein Services for HDAC6
	GenScript Custom Purified and Recombinant Proteins Services for HDAC6
	Novus Biologicals HDAC6 Proteins Novus Biologicals HDAC6 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HDAC6

Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000118	histone deacetylase complex	IDA	11948178
GO:0005622	intracellular	--	--
GO:0005634	nucleus	ISS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	ISS	11861901

HDAC6 for ontologies About GeneDecksing

HDAC6 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HDAC6
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for HDAC6
	OriGene Antibodies (see all 10): HDAC6 OriGene Custom Antibody Services for HDAC6
	GenScript Custom Superior Antibodies Services for HDAC6
	Novus Biologicals HDAC6 Antibodies
	Abcam antibodies for HDAC6
	Uscn Antibodies for HDAC6
	ThermoFisher Antibodies for HDAC6

Assay Products for HDAC6:

	EMD Millipore Kits and Assays for the Analysis of HDAC6
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HDAC6
	Enzo Life Sciences assays for HDAC6
	Uscn ELISAs and CLIAs for HDAC6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HDAC6 for domains About GeneDecksing

4 InterPro domains/families:

IPR013083 Znf_RING/FYVE/PHD

IPR000286 His_deacetylse

IPR001607 Znf_UBP

IPR023801 His_deacetylse_dom

Graphical View of Domain Structure for InterPro Entry Q9UBN7

ProtoNet protein and cluster: Q9UBN7

2 Blocks protein families:

IPB000286 Histone deacetylase superfamily signature

IPB001607 Zn-finger in ubiquitin thiolesterase

UniProtKB/Swiss-Prot: HDAC6_HUMAN, Q9UBN7

Similarity: Belongs to the histone deacetylase family. HD type 2 subfamily

Similarity: Contains 1 UBP-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HDAC6_HUMAN, Q9UBN7

Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B,

H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional

regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large

multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation

of tubulin

Function: In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins:

when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the

ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called

aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the

aggresome, facilitating their clearance by autophagy

Catalytic activity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone

Enzyme Number (IUBMB): EC 3.5.1.98¹ ²

miRNA Products:		OriGene 3'-UTR Clone: HDAC6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HDAC6
		1 QIAGEN miScript miRNA Assays for microRNA that regulate HDAC6:
		hsa-miR-1207-5p
		SwitchGear 3'UTR luciferase reporter plasmid: HDAC6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDAC6 (see all 4) OriGene shRNA RFP: HDAC6 OriGene siRNA: HDAC6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDAC6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HDAC6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDAC6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDAC6 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HDAC6 (NM_006044)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDAC6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDAC6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HDAC6
		Search LifeMap BioReagents cell lines for HDAC6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDAC6

Gene Ontology (GO): 5/21 molecular function terms (GO ID links to tree view) (see all 21): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0004407	histone deacetylase activity	IDA	10220385
GO:0005515	protein binding	IPI	--
GO:0008013	beta-catenin binding	IPI	18356165
GO:0008017	microtubule binding	ISS	--

HDAC6 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for HDAC6:

Cell division defect

Increased G2M DNA content

Increased number of mitotic ce

Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-out Hdac6^tm1.1Pmt for HDAC6
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hdac6):

growth/size	immune system	nervous system	normal	reproductive system
skeleton

HDAC6 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant

8/12 pathways (see all 12)
Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant	1.00	Signaling by NOTCH1	1.00
Signaling by NOTCH1 PEST Domain Mutants in Cancer	1.00	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.79
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	1.00	Signaling by NOTCH	0.77
Signaling by NOTCH1 in Cancer	1.00	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.71

DNA Methylation and Transcriptional Repression

DNA Methylation and Transcriptional Repression

1.00

Macrophage Differentiation and Growth Inhibition by METS

0.30

Cyclins and Cell Cycle Regulation

Cyclins and Cell Cycle Regulation

1.00

G1-S Phase Transition

0.67

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Disease

Disease

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for HDAC6

Histone modification

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HDAC6 (see all 15)

	DNA Methylation and Transcriptional Repression
	Protein Acetylation and Deacetylation
	BRCA1 Pathway
	Glucocorticoid Receptor Signaling
	Intracellular Calcium Signaling

1 Cell Signaling Technology (CST) Pathway for HDAC6

Chromatin Regulation / Acetylation

1 GeneGo (Thomson Reuters) Pathway for HDAC6

Regulation of degradation of deltaF508 CFTR in CF

5 BioSystems Pathways for HDAC6

	Cell cycle
	Neural Crest Differentiation
	TNF-alpha/NF-kB Signaling Pathway
	Signaling events mediated by HDAC Class I
	Signaling events mediated by HDAC Class II

5/13 Reactome Pathways for HDAC6 (see all 13)

	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	NOTCH1 Intracellular Domain Regulates Transcription
	Signaling by NOTCH
	FBXW7 Mutants and NOTCH1 in Cancer
	Signaling by NOTCH1 HD Domain Mutants in Cancer

HDAC6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HDAC6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/235 Interacting proteins for HDAC6 (Q9UBN7^{1, 2, 3} ENSP00000334061⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 235)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST4H4	P62805³, ENSP00000350767⁴	I2D: score=1 STRING: ENSP00000350767
HIST1H4L	P62805³, ENSP00000348258⁴	I2D: score=1 STRING: ENSP00000348258
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/37 biological process terms (GO ID links to tree view) (see all 37): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000209	protein polyubiquitination	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006476	protein deacetylation	IMP	15916966
GO:0006511	ubiquitin-dependent protein catabolic process	--	--
GO:0006515	misfolded or incompletely synthesized protein catabolic process	IMP	14675537

HDAC6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HDAC6 for compounds About GeneDecksing

EMD Millipore small molecules for HDAC6:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for HDAC6

Compounds for HDAC6 available from Tocris Bioscience About this table

Compound	Action	CAS #
NCH 51	Histone deacetylase inhibitor	[848354-66-5]
Splitomicin	Sir2p inhibitor	[5690-03-9]
Trichostatin A	Histone deacetylase inhibitor	[58880-19-6]
KD 5170	Histone deacetylase inhibitor	[940943-37-3]
Sodium 4-Phenylbutyrate	Histone deacetylase inhibitor	[1716-12-7]

1 DrugBank Compound for HDAC6 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Vorinostat	MK0683 (see all 7)	149647-78-9	target	inhibitor	17694093

10/14 Novoseek chemical compound relationships for HDAC6 gene (see all 14) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
trapoxin b	92.3	3	14670976 (1), 12391164 (1)
trapoxin	84.4	8	12486003 (2), 11134513 (2)
hydroxamate	71.5	4	15018907 (2), 15937340 (1)
leptomycin b	44.4	4	15347674 (3)
paclitaxel	34.4	5	15867388 (2), 17914112 (1)
taxane	32.6	4	15867388 (2), 16951201 (1)
lysine	31.7	3	19084395 (1), 19272776 (1)
estrogen	17.9	18	15806142 (4), 15501975 (2), 19744931 (2), 19318565 (1)
zinc	8.2	2	15347674 (1)
atp	0	2	15937340 (1), 18591380 (1)

Search CenterWatch for drugs/clinical trials and news about HDAC6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HDAC6 gene:

NM_006044.2

Unigene Cluster for HDAC6:

Histone deacetylase 6

Hs.6764 [show with all ESTs]

Unigene Representative Sequence: BC069243

18/38 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 38):

ENST00000423941 ENST00000438518 ENST00000376643 ENST00000469223 ENST00000376610

ENST00000483656 ENST00000334136(uc004dks.1) ENST00000462730(uc004dkr.1 uc004dku.4)

ENST00000376619(uc011mmi.1 uc004dkt.1 uc011mmk.1) ENST00000477528(uc010nig.1)

ENST00000465269 ENST00000476625 ENST00000477561 ENST00000481929 ENST00000441703

ENST00000426196 ENST00000489352 ENST00000443563

miRNA Products:		OriGene 3'-UTR Clone: HDAC6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HDAC6
		1 QIAGEN miScript miRNA Assays for microRNA that regulate HDAC6:
		hsa-miR-1207-5p
		SwitchGear 3'UTR luciferase reporter plasmid: HDAC6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDAC6 (see all 4) OriGene shRNA RFP: HDAC6 OriGene siRNA: HDAC6
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		GenScript: all cDNA clones in your preferred vector: HDAC6 (NM_006044)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDAC6

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDAC6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDAC6

Additional cDNA sequence:

AB020708.1 AF132609.1 AF174499.1 AJ011972.1 AK001543.1 AK024083.1 AK095124.1 AK131286.1

AK295884.1 AK302926.1 AK303012.1 AK309058.1 BC005872.1 BC011498.1 BC013219.1 BC013737.1

BC069243.1 BT006649.1

24/26 DOTS entries (see all 26):

DT.454536 DT.100641905 DT.95284368 DT.100667519 DT.92440000 DT.91944356 DT.92439998 DT.75128370

DT.91987075 DT.95108077 DT.100730371 DT.101984370 DT.121324034 DT.121324096 DT.121324102 DT.92439999

DT.95140549 DT.97812734 DT.100791506 DT.121324015 DT.99939658 DT.100791521 DT.100791522 DT.121324058

24/236 AceView cDNA sequences (see all 236):

AA228073 AV649284 AL041491 CF264944 CD675745 AK127118 BE326986 CB216350

AU142216 AW028077 AU117930 AB020708 AF132609 BM711014 AW184022 AI031785

CA307689 AA765717 BU956553 BX103526 AA722411 AA227968 AK095124 AA861455

GeneLoc Exon Structure

5/22 Alternative Splicing Database (ASD) splice patterns (SP) for HDAC6 (see all 22) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13	^
SP1:							-		-		-		-		-																-		-		-
SP2:									-		-		-		-																-		-		-
SP3:															-								-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP4:
SP5:

ExUns:	14a	·	14b	^	15a	·	15b	^	16a	·	16b	·	16c	^	17	^	18	^	19	^	20	^	21	^	22a	·	22b	·	22c	^	23a	·	23b	^	24a	·	24b	·	24c	^	25	^	26	^	27a	·	27b	·	27c	·	27d	·
SP1:	-						-		-								-																		-
SP2:	-						-		-								-																		-
SP3:	-		-		-		-		-		-						-																		-
SP4:																	-																		-
SP5:

ExUns:	27e	^	28	^	29a	·	29b	·	29c	^	30a	·	30b	·	30c	^	31	^	32	^	33a	·	33b	^	34
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for HDAC6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HDAC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAAGGTTGC

About this image
See HDAC6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HDAC6

SOURCE GeneReport for Unigene cluster: Hs.6764

SABiosciences Expression via Pathway-Focused PCR Arrays including HDAC6:

Epigenetic Chromatin Modification Enzymes in human mouse rat

Cancer Drug Targets in human mouse rat

Autophagy in human mouse rat

Nuclear Receptors & Coregulators in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HDAC6 gene from 7/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	HDAC6⁶	--	50(a)	1 ↔ 1	2(86353464-86414567)
African clawed frog (Xenopus laevis)	Amphibia	hdac6-prov²	histone deacetylase 6	75.99(n)		BC043813.1
zebrafish (Danio rerio)	Actinopterygii	hdac6¹	histone deacetylase 6	58.17(n) 52.61(a)		565482 XM_688766.5 XP_693858.4
fruit fly (Drosophila melanogaster)	Insecta	HDAC6^{1 , 3}	histone deacetylase³ CG6170-PA¹	45(a)³ 52(n)¹ 45.76(a)¹		13B6³ 32461¹ NM_167436.3¹ NP_727842.1¹
worm (Caenorhabditis elegans)	Secernentea	Y51H1A.5³ hda-6¹	Histone deacetylase family³ Protein HDA-6¹	40(a) (best of 4)³ 48.3(n)¹ 42.44(a)¹		II(13882603-13887835)³ 177316¹ NM_068386.3¹ NP_500787.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	HDA15⁶ hda14⁶ (see all 5)	histone deacetylase 14 (see all 5)	27(a) 23(a) (see all 5)	many ↔ many possible ortholog (see all 5)	3(6361176-6365615) 4(16102595-16105493)
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	histone deacetylase, putative, expressed (see all 5)	24(a) 24(a) (see all 5)	many ↔ many many ↔ many (see all 5)	7(3434934-3443792) 7(24591010-24597360)

ENSEMBL Gene Tree for HDAC6 (if available)
TreeFam Gene Tree for HDAC6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HDAC6 gene

HDAC9² HDAC5² HDAC4² HDAC7² HDAC10²

8 SIMAP similar genes for HDAC6 using alignment to 11 protein entries: HDAC6_HUMAN (see all proteins):

DKFZp566E044 HDAC9 USP44 HDAC10 HDAC7 USP3

KIAA0600 HDAC4

HDAC6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188815681^1,2		--	48658515(+)	`CCCATA/GAATCC`	1	--	us2k¹		0	--	--	--	--
rs137925626^1,2		--	48658520(+)	`GAATCC/TCTGTC`	1	--	us2k¹		0	--	--	--	--
rs34955786^1,2	C	--	48658587(-)	`TTGCAG/AGATTG`	1	--	us2k¹		2		NA	4
rs191952249^1,2		--	48658660(+)	`ATTCAA/GGCCAA`	1	--	us2k¹		0	--	--	--	--
rs35189789^1,2	C	--	48658753(-)	`TTGCAG/AGCCAC`	1	--	us2k¹		2		NA	4
rs143480781^1,2		--	48659110(+)	`GATGCA/GGAACC`	1	--	us2k¹		0	--	--	--	--
rs150537073^1,2		--	48659154(+)	`AGCCCA/GGTAGG`	1	--	us2k¹		0	--	--	--	--
rs17281209^1,2	C,F,H,	--	48659228(+)	`TAGACA/GTGGAG`	1	--	us2k¹		11		NA NS	1506
rs184188843^1,2		--	48659615(+)	`CACTCA/GGAATA`	1	--	us2k¹		0	--	--	--	--
rs186664222^1,2		--	48659621(+)	`GAATAC/TTGCGG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HDAC6 (48659784 - 48683392 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HDAC6
1 CNV: 7789
Locus Specific Mutation Databases (LSDB): HDAC6

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HDAC6 for disorders           About GeneDecksing

OMIM gene information: 300272    OMIM disorders: --

20/41 diseases for HDAC6 (see all 41):    About MalaCards

estrogen-receptor positive breast cancer clostridium difficile amyotrophic lateral sclerosis b-cell lymphomas

oral squamous cell carcinoma lateral sclerosis squamous cell carcinoma acute lymphoblastic leukemia

neurodegenerative disease lymphoblastic leukemia acute myeloid leukemia myeloid leukemia

cutaneous t cell lymphoma chondrodysplasia multiple myeloma breast cancer

huntington's disease leukemia parkinson's disease acute leukemia

7 Novoseek disease relationships for HDAC6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	32	10	19329208 (2), 19228685 (1), 19888759 (1), 15501975 (1) (see all 8)
neurodegenerative diseases	23.5	4	19036992 (1), 18606987 (1), 20520769 (1), 17912024 (1)
shock	20.5	5	17938201 (1), 18591380 (1), 18660379 (1)
breast cancer	19	13	15501975 (5), 15806142 (3), 19372552 (1), 19744931 (1) (see all 6)
virus infection	0	2	18472263 (1)
primary tumor	0	1	16773191 (1)
tumors	0	9	16773191 (3), 19318486 (2), 15501975 (1), 18499657 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: HDAC6 (4 documents)

Export disorders for HDAC6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HDAC6 gene, integrated from 9 sources (see all 240):
(articles sorted by number of sources associating them with HDAC6)

Utopia: connect your pdf to the dynamic
world of online information

Three proteins define a class of human histone deacetylases related to yeast Hda1p. (PubMed id 10220385)^{1, 2, 3, 9} Grozinger C.M....Schreiber S.L. (1999)
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2, 3} Nagase T....Ohara O. (1998)
HDAC6 is a microtubule-associated deacetylase. (PubMed id 12024216)^{1, 2, 9} Hubbert C.... Yao T.-P. (2002)
The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition. (PubMed id 19033385)^{1, 2, 9} Kalveram B....Groettrup M. (2008)
Requirement of a novel splicing variant of human hist one deacetylase 6 for TGF-beta1-mediated gene activation. (PubMed id 20102703)^{1, 2, 9} Zhuang Y....Shan B. (2010)
CYLD negatively regulates cell-cycle progression by i nactivating HDAC6 and increasing the levels of acetylated tubulin. (PubMed id 19893491)^{1, 2, 9} WickstrAPm S.A....Massoumi R. (2010)
HEF1-dependent Aurora A activation induces disassembly of the primary cilium. (PubMed id 17604723)^{1, 2, 9} Pugacheva E.N....Golemis E.A. (2007)
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. (PubMed id 12620231)^{1, 2, 9} North B.J.... Verdin E. (2003)
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. (PubMed id 17846173)^{1, 2} Olzmann J.A....Chin L.S. (2007)
Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. (PubMed id 12354939)^{1, 2} Hook S.S.... Eisenman R.N. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10013	HGNC: 14064	AceView: HDAC6	Ensembl:ENSG00000094631	euGenes: HUgn10013
ECgene: HDAC6	H-InvDB: HDAC6

(According to HUGE)
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HUGE: KIAA0901

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HDAC6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HDAC6	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for HDAC6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HDAC6 gene:
Search GeneIP for patents involving HDAC6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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histone deacetylase 6

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HDAC6 Gene

histone deacetylase 6

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