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HDAC6 Gene

protein-coding   GIFtS: 73
GCID: GC0XP048659

Histone Deacetylase 6

  See HDAC6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Deacetylase 61 2
HD62 3
EC 3.5.1.983 8
CPBHM2 5
KIAA09013

External Ids:    HGNC: 140641   Entrez Gene: 100132   Ensembl: ENSG000000946317   OMIM: 3002725   UniProtKB: Q9UBN73   

Export aliases for HDAC6 gene to outside databases

Previous GC identifers: GC0XP047463 GC0XP046921 GC0XP047706 GC0XP048416 GC0XP048545 GC0XP046319


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HDAC6 Gene:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.
Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The
protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an
internal duplication of two catalytic domains which appear to function independently of each other. This protein
possesses histone deacetylase activity and represses transcription. (provided by RefSeq, Jul 2008)

GeneCards Summary for HDAC6 Gene:
HDAC6 (histone deacetylase 6) is a protein-coding gene. Diseases associated with HDAC6 include chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia, and cohen syndrome. GO annotations related to this gene include microtubule binding and actin binding. An important paralog of this gene is HDAC9.

UniProtKB/Swiss-Prot: HDAC6_HUMAN, Q9UBN7
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A,
H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in
transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the
formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell
motility via deacetylation of tubulin
Function: In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded
proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the
ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called
aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to
the aggresome, facilitating their clearance by autophagy

summary for HDAC6 Gene:
Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal
of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional
repression. In general, they do not act autonomously but as components of large multiprotein complexes, such
as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of
HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously
expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by
protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the
class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the
nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to
substantial interest in HDAC inhibitors as possible antineoplastic agents.

Gene Wiki entry for HDAC6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_079573.5  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HDAC6 gene promoter:
         AML1a   p300   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): HDAC6 promoter sequence
   Search Chromatin IP Primers for HDAC6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HDAC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

HDAC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDAC6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP048659:  view genomic region     (about GC identifiers)

Start:
48,659,784 bp from pter      End:
48,683,392 bp from pter
Size:
23,609 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HDAC6_HUMAN, Q9UBN7 (See protein sequence)
Recommended Name: Histone deacetylase 6  
Size: 1215 amino acids; 131419 Da
Cofactor: Binds 3 zinc ions per subunit
Subunit: Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome
impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions.
Interacts with CYLD. Interacts with ZMYND15 (By similarity). Interacts with DDIT3/CHOP
Sequence caution: Sequence=BAA74924.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for HDAC6:
3C5K (3D)        3GV4 (3D)        3PHD (3D)    
Secondary accessions: O94975 Q6NT75 Q7L3E5 Q96CY0
Alternative splicing: 2 isoforms:  Q9UBN7-1   Q9UBN7-2   (Required for TGF-beta1-activated gene expression associated with epithelial-mesenchymal transition (EMT) in A549 cells)

Explore the universe of human proteins at neXtProt for HDAC6: NX_Q9UBN7

Explore proteomics data for HDAC6 at MOPED

Post-translational modifications: 

  • Phosphorylated by AURKA1
  • Ubiquitinated. Its polyubiquitination however does not lead to its degradation1
  • Sumoylated in vitro1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for HDAC6 (Q9UBN7) (see all 5)
     LEGGYNL  LMGLAGG  HHGNGTQ  VDWDVHHG 


    See HDAC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006035.2  
    ENSEMBL proteins: 
     ENSP00000392815   ENSP00000403370   ENSP00000365831   ENSP00000365795   ENSP00000334061  
     ENSP00000365804   ENSP00000393916   ENSP00000402189   ENSP00000402751   ENSP00000394377  
     ENSP00000397697   ENSP00000398566   ENSP00000398801  
    Reactome Protein details: Q9UBN7

    HDAC6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for HDAC6
    OriGene Purified Protein for HDAC6
    OriGene Protein Over-expression Lysate for HDAC6
    OriGene MassSpec for HDAC6
    OriGene Custom Protein Services for HDAC6
    GenScript Custom Purified and Recombinant Proteins Services for HDAC6
    Novus Biologicals HDAC6 Proteins
    Novus Biologicals HDAC6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HDAC6

     
    Search eBioscience for Proteins for HDAC6 

    HDAC6 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HDAC6
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for HDAC6 
    OriGene Antibodies for HDAC6
    OriGene Custom Antibody Services for HDAC6
    Novus Biologicals HDAC6 Antibodies
    Abcam antibodies for HDAC6
    Cloud-Clone Corp. Antibodies for HDAC6
    ThermoFisher Antibodies for HDAC6
    LSBio Antibodies in human, mouse, rat for HDAC6

    HDAC6 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of HDAC6
    OriGene Custom Assay Services for HDAC6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HDAC6
    Enzo Life Sciences assays for HDAC6
    Cloud-Clone Corp. ELISAs for HDAC6
    Cloud-Clone Corp. CLIAs for HDAC6
    Search eBioscience for ELISAs for HDAC6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013083 Znf_RING/FYVE/PHD
     IPR000286 His_deacetylse
     IPR001607 Znf_UBP
     IPR023801 His_deacetylse_dom

    Graphical View of Domain Structure for InterPro Entry Q9UBN7

    ProtoNet protein and cluster: Q9UBN7

    2 Blocks protein domains:
    IPB000286 Histone deacetylase superfamily signature
    IPB001607 Zn-finger in ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: HDAC6_HUMAN, Q9UBN7
    Similarity: Belongs to the histone deacetylase family. HD type 2 subfamily
    Similarity: Contains 1 UBP-type zinc finger


    Find genes that share domains with HDAC6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HDAC6_HUMAN, Q9UBN7
    Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A,
    H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in
    transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the
    formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell
    motility via deacetylation of tubulin
    Function: In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded
    proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the
    ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called
    aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to
    the aggresome, facilitating their clearance by autophagy
    Catalytic activity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone

         Enzyme Number (IUBMB): EC 3.5.1.981 2

         Gene Ontology (GO): Selected molecular function terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004407histone deacetylase activity IDA10220385
    GO:0005515protein binding IPI16919237
    GO:0008013beta-catenin binding IPI18356165
    GO:0008017microtubule binding ISS--
         
    Find genes that share ontologies with HDAC6           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for HDAC6:
     Cell division defect  Increased G2M DNA content  Increased number of mitotic ce  Upregulation of Wnt/beta-caten 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hdac6):
     behavior/neurological  growth/size/body  hematopoietic system  immune system  mortality/aging 
     nervous system  normal  reproductive system  skeleton 

    Find genes that share phenotypes with HDAC6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hdac6tm1.1Pmt for HDAC6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HDAC6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HDAC6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HDAC6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HDAC6

    miRNA
    Products:
        
    miRTarBase miRNAs that target HDAC6:
    hsa-mir-181a-5p (MIRT047316), hsa-mir-335-5p (MIRT017204)

    Block miRNA regulation of human, mouse, rat HDAC6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HDAC6:
    hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidHDAC6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HDAC6
    Predesigned siRNA for gene silencing in human, mouse, rat HDAC6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HDAC6

    Clone
    Products:
         
    OriGene clones in human, mouse for HDAC6 (see all 9)
    OriGene ORF clones in mouse, rat for HDAC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HDAC6 (NM_006044)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDAC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDAC6
    Addgene plasmids for HDAC6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HDAC6
    Browse ESI BIO Cell Lines and PureStem Progenitors for HDAC6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDAC6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HDAC6_HUMAN, Q9UBN7: Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4
    plasma membrane4
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex IDA11948178
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS11861901
    GO:0005829cytosol ISS--
    GO:0005874microtubule IDA12620231

    Find genes that share ontologies with HDAC6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HDAC6 About   (see all 26)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    2Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1-S Phase Transition0.67
    3Macrophage Differentiation and Growth Inhibition by METS
    Macrophage Differentiation and Growth Inhibition by METS0.30
    DNA Methylation and Transcriptional Repression0.30
    4Cell cycle
    Cell cycle0.59
    5Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of deltaF508 CFTR in CF0.59


    Find genes that share SuperPaths with HDAC6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HDAC6 (see all 15)
        DNA Methylation and Transcriptional Repression
    Protein Acetylation and Deacetylation
    BRCA1 Pathway
    Glucocorticoid Receptor Signaling
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for HDAC6
        Chromatin Regulation / Acetylation

    1 GeneGo (Thomson Reuters) Pathway for HDAC6
        Regulation of degradation of deltaF508 CFTR in CF

    5 BioSystems Pathways for HDAC6
        Cell cycle
    Neural Crest Differentiation
    TNF-alpha/NF-kB Signaling Pathway
    Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class II

    4 Reactome Pathways for HDAC6
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    HSF1 activation
    Constitutive Signaling by NOTCH1 PEST Domain Mutants


    2 Kegg Pathways  (Kegg details for HDAC6):
        Alcoholism
    Viral carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HDAC6: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat
              Autophagy in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HDAC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HDAC6 (Q9UBN71, 2, 3 ENSP000003340614) via UniProtKB, MINT, STRING, and/or I2D (see all 335)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST4H4P628053, ENSP000003507674I2D: score=1 STRING: ENSP00000350767
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006476protein deacetylation IMP15916966
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0006515misfolded or incompletely synthesized protein catabolic process IMP14675537

    Find genes that share ontologies with HDAC6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for HDAC6
    Selected ApexBio Compounds for HDAC6 (see all 29)     About this table
    CompoundAction CAS #
    AR-42 (OSU-HDAC42)Pan-HDAC inhibitor[935881-37-1]
    Belinostat (PXD101)Novel and potent hydroxamate-type HDAC inhibitor[414864-00-9]
    CI994 (Tacedinaline)HDAC1 and 3 inhibitor[112522-64-2]
    CUDC-101Multitargeted HDAC inhibitor[1012054-59-9]
    CUDC-907PI3K and HDAC inhibitor[1339928-25-4]
    DroxinostatSelective HDAC inhibitor[99873-43-5]
    Entinostat (MS-275,SNDX-275)Entinostat inhibits HDAC1 and HDAC3 but not HDAC8[209783-80-2]
    ITF2357 (Givinostat)HDAC inhibitor, inhibits class I and class II HDACs[732302-99-7]
    JNJ-26481585Potent pan-HDAC inhibitor[875320-29-9]
    LAQ824 (NVP-LAQ824,Dacinostat)Novel and potent HDAC inhibitor[404951-53-7]

    Compounds for HDAC6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TCS HDAC6 20bSelective HDAC6 inhibitor[956154-63-5]
    LMK 235Selective HDAC4/HDAC5 inhibitor[1418033-25-6]
    Trichostatin AHistone deacetylase inhibitor[58880-19-6]
    TubacinHDAC6 inhibitor; inhibits alpha-tubulin deacetylation[1350555-93-9]
    Sodium 4-PhenylbutyrateHistone deacetylase inhibitor[1716-12-7]

    1 DrugBank Compound for HDAC6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    VorinostatMK0683 (see all 7)149647-78-9targetinhibitor17694093

    Selected Novoseek inferred chemical compound relationships for HDAC6 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trapoxin b 92.3 3 14670976 (1), 12391164 (1)
    trapoxin 84.4 8 12486003 (2), 11134513 (2)
    hydroxamate 71.5 4 15018907 (2), 15937340 (1)
    leptomycin b 44.4 4 15347674 (3)
    paclitaxel 34.4 5 15867388 (2), 17914112 (1)
    taxane 32.6 4 15867388 (2), 16951201 (1)
    lysine 31.7 3 19084395 (1), 19272776 (1)
    estrogen 17.9 18 15806142 (4), 15501975 (2), 19744931 (2), 19318565 (1)
    zinc 8.2 2 15347674 (1)
    atp 0 2 15937340 (1), 18591380 (1)



    Find genes that share compounds with HDAC6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HDAC6 gene: 
    NM_006044.2  

    Unigene Cluster for HDAC6:

    Histone deacetylase 6
    Hs.6764  [show with all ESTs]
    Unigene Representative Sequence: BC069243
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 38):
    ENST00000423941 ENST00000438518 ENST00000376643 ENST00000469223 ENST00000376610
    ENST00000483656 ENST00000334136(uc004dks.1) ENST00000462730(uc004dkr.1 uc004dku.4)
    ENST00000376619(uc011mmi.1 uc004dkt.1 uc011mmk.1) ENST00000477528(uc010nig.1)
    ENST00000465269 ENST00000476625 ENST00000477561 ENST00000481929 ENST00000441703
    ENST00000426196 ENST00000489352 ENST00000443563
    miRNA
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    Block miRNA regulation of human, mouse, rat HDAC6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HDAC6:
    hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidHDAC6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HDAC6
    Predesigned siRNA for gene silencing in human, mouse, rat HDAC6
    Clone
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    OriGene clones in human, mouse for HDAC6 (see all 9)
    OriGene ORF clones in mouse, rat for HDAC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HDAC6 (NM_006044)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDAC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDAC6
    Addgene plasmids for HDAC6 
    Primer
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    OriGene qPCR primer pairs and template standards for HDAC6
    OriGene qSTAR qPCR primer pairs in human, mouse for HDAC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HDAC6
      QuantiTect SYBR Green Assays in human, mouse, rat HDAC6
      QuantiFast Probe-based Assays in human, mouse, rat HDAC6

    Additional mRNA sequence: 

    AB020708.1 AF132609.1 AF174499.1 AJ011972.1 AK001543.1 AK024083.1 AK095124.1 AK131286.1 
    AK295884.1 AK302926.1 AK303012.1 AK309058.1 BC005872.1 BC011498.1 BC013219.1 BC013737.1 
    BC069243.1 BT006649.1 

    Selected DOTS entries (see all 26):

    DT.454536  DT.100641905  DT.95284368  DT.100667519  DT.92440000  DT.91944356  DT.92439998  DT.75128370 
    DT.91987075  DT.95108077  DT.100730371  DT.101984370  DT.121324034  DT.121324096  DT.121324102  DT.92439999 
    DT.95140549  DT.97812734  DT.100791506  DT.121324015  DT.99939658  DT.100791521  DT.100791522  DT.121324058 

    Selected AceView cDNA sequences (see all 236):

    BX103526 BE326986 AI419296 AB020708 AI422038 BU956553 AF132609 BX644567 
    AW243758 BX448222 AK095124 AK122954 AJ011972 BC013219 CA307689 AL041491 
    BQ638151 AK127118 AW249578 BF528644 BM719977 BU943977 BF981688 BX505022 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HDAC6 (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
    SP1:                    -     -     -     -     -                                               -     -     -                                                   
    SP2:                          -     -     -     -                                               -     -     -                                                   
    SP3:                                            -                       -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b · 24c ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d ·
    SP1:  -                 -     -                       -                                                     -                                                   
    SP2:  -                 -     -                       -                                                     -                                                   
    SP3:  -     -     -     -     -     -                 -                                                     -                                                   
    SP4:                                                  -                                                     -                                                   
    SP5:                                                                                                                                                            

    ExUns: 27e ^ 28 ^ 29a · 29b · 29c ^ 30a · 30b · 30c ^ 31 ^ 32 ^ 33a · 33b ^ 34
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for HDAC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HDAC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAGGTTGC
    HDAC6 Expression
    About this image


    HDAC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
     
     Umbilical Cord (Extraembryonic Tissues)
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
    HDAC6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HDAC6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6764
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HDAC6: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat
              Autophagy in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HDAC6 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hdac61 , 5 histone deacetylase 61, 5 81.38(n)1
    79.03(a)1
      X (3.58 cM)5
    151851  NM_010413.31  NP_034543.31 
     79301205 
    lizard
    (Anolis carolinensis)
    Reptilia HDAC66
    histone deacetylase 6
    50(a)
    1 ↔ 1
    2(86353046-86417358)
    African clawed frog
    (Xenopus laevis)
    Amphibia hdac6-prov2 histone deacetylase 6 75.99(n)    BC043813.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hdac61 histone deacetylase 6 58.06(n)
    52.55(a)
      565482  XM_688766.6  XP_693858.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta HDAC61 , 3 histone deacetylase3
    HDAC61
    45(a)3
    52.45(n)1
    45.97(a)1
      13B63
    324611  NM_001272640.11  NP_001259569.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y51H1A.53
    hda-61
    Histone deacetylase family3
    hda-61
    40(a)
    (best of 4)3
    48.34(n)1
    42.44(a)1
      II(13882603-13887835)3
    1773161  NM_068386.31  NP_500787.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HDA1(YNL021W)4 Putative catalytic subunit of a class II histone deacetylase more   --   14(593227-595347) 855710  NP_014377.1 
    corn
    (Zea mays)
    Liliopsida Zm.24982 Zea mays CL14611_1 mRNA sequence 78.03(n)    AF322918.1 


    ENSEMBL Gene Tree for HDAC6 (if available)
    TreeFam Gene Tree for HDAC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HDAC6 gene
    HDAC92  HDAC52  HDAC72  HDAC42  HDAC102  
    8 SIMAP similar genes for HDAC6 using alignment to 11 protein entries:     HDAC6_HUMAN (see all proteins):
    DKFZp566E044    HDAC9    USP44    HDAC10    HDAC7    USP3
    KIAA0600    HDAC4

    Find genes that share paralogs with HDAC6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for HDAC6 (see all 359)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888156811,2
    --48578255(+) CCCATA/GAATCC 1 -- us2k10--------
    rs1379256261,2
    C--48578260(+) GAATCC/TCTGTC 1 -- us2k10--------
    rs349557861,2
    C--48578327(-) TTGCAG/AGATTG 1 -- us2k12Minor allele frequency- A:0.00NA 4
    rs1919522491,2
    --48578400(+) ATTCAA/GGCCAA 1 -- us2k10--------
    rs351897891,2
    C--48578493(-) TTGCAG/AGCCAC 1 -- us2k12Minor allele frequency- A:0.00NA 4
    rs1434807811,2
    --48578850(+) GATGCA/GGAACC 1 -- us2k10--------
    rs1505370731,2
    --48578894(+) AGCCCA/GGTAGG 1 -- us2k10--------
    rs172812091,2
    C,F,H--48578968(+) TAGACA/GTGGAG 1 -- us2k111Minor allele frequency- G:0.02NA NS 1506
    rs1841888431,2
    C--48579355(+) CACTCA/GGAATA 1 -- us2k10--------
    rs1866642221,2
    --48579361(+) GAATAC/TTGCGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HDAC6 (48659784 - 48683392 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HDAC6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6893CNV Insertion18451855
    nsv528292CNV Gain19592680
    esv32909CNV Gain+Loss17666407

    Human Gene Mutation Database (HGMD): HDAC6
    Locus Specific Mutation Databases (LSDB): HDAC6

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HDAC6
    DNA2.0 Custom Variant and Variant Library Synthesis for HDAC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 300272   
    OMIM disorders: 300863  
    UniProtKB/Swiss-Prot: HDAC6_HUMAN, Q9UBN7
  • Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia
    (CDP-PBHM) [MIM:300863]: A disease characterized by chondrodysplasia, severe platyspondyly, hydrocephaly, and
    facial features with microphthalmia. Bone abnormalities include a distinctive metaphyseal cupping of the
    metacarpals, metatarsals, and phalanges. Affected females show a milder phenotype with small stature, sometimes
    associated with body asymmetry and mild mental retardation. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 3 diseases for HDAC6:    
    About MalaCards
    chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia    cohen syndrome    alexander disease


    Find genes that share disorders with HDAC6           About GenesLikeMe

    7 Novoseek inferred disease relationships for HDAC6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 32 10 19329208 (2), 19228685 (1), 19888759 (1), 15501975 (1) (see all 8)
    neurodegenerative diseases 23.5 4 19036992 (1), 18606987 (1), 20520769 (1), 17912024 (1)
    shock 20.5 5 17938201 (1), 18591380 (1), 18660379 (1)
    breast cancer 19 13 15501975 (5), 15806142 (3), 19372552 (1), 19744931 (1) (see all 6)
    virus infection 0 2 18472263 (1)
    primary tumor 0 1 16773191 (1)
    tumors 0 9 16773191 (3), 19318486 (2), 15501975 (1), 18499657 (1) (see all 5)

    Genetic Association Database (GAD): HDAC6
    Human Genome Epidemiology (HuGE) Navigator: HDAC6 (4 documents)

    Export disorders for HDAC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HDAC6 gene, integrated from 10 sources (see all 277):
    (articles sorted by number of sources associating them with HDAC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three proteins define a class of human histone deacetylases related to yeast Hda1p. (PubMed id 10220385)1, 2, 3, 9 Grozinger C.M.... Schreiber S.L. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    3. HDAC6 is a microtubule-associated deacetylase. (PubMed id 12024216)1, 2, 9 Hubbert C.... Yao T.-P. (Nature 2002)
    4. The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition. (PubMed id 19033385)1, 2, 9 Kalveram B.... Groettrup M. (J. Cell Sci. 2008)
    5. Requirement of a novel splicing variant of human histone deacetylase 6 for TGF-beta1-mediated gene activation. (PubMed id 20102703)1, 2, 9 Zhuang Y.... Shan B. (Biochem. Biophys. Res. Commun. 2010)
    6. CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. (PubMed id 19893491)1, 2, 9 Wickstrom S.A.... Massoumi R. (EMBO J. 2010)
    7. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. (PubMed id 17604723)1, 2, 9 Pugacheva E.N....Golemis E.A. (Cell 2007)
    8. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. (PubMed id 12620231)1, 2, 9 North B.J.... Verdin E. (Mol. Cell 2003)
    9. A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia. (PubMed id 20181727)1, 2 Simon D....Arveiler B. (Hum. Mol. Genet. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10013 HGNC: 14064 AceView: HDAC6 Ensembl:ENSG00000094631 euGenes: HUgn10013
    ECgene: HDAC6 Kegg: 10013 H-InvDB: HDAC6

    (According to HUGE)
    About This Section

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    HUGE: KIAA0901

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HDAC6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HDAC6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HDAC6 gene:
    Search GeneIP for patents involving HDAC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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