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Aliases for HDAC4 Gene

Aliases for HDAC4 Gene

  • Histone Deacetylase 4 2 3
  • EC 3.5.1.98 4 63
  • HDACA 3 6
  • AHO3 3 6
  • BDMR 3 6
  • HD4 3 4
  • Brachydactyly-Mental Retardation Syndrome 2
  • Histone Deacetylase A 3
  • KIAA0288 4
  • HA6116 3
  • HDAC-4 3
  • HDAC-A 3

External Ids for HDAC4 Gene

Previous HGNC Symbols for HDAC4 Gene

  • BDMR

Previous GeneCards Identifiers for HDAC4 Gene

  • GC02M237911
  • GC02M238543
  • GC02M239886
  • GC02M240182
  • GC02M239707
  • GC02M239634
  • GC02M239969
  • GC02M231741

Summaries for HDAC4 Gene

Entrez Gene Summary for HDAC4 Gene

  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]

GeneCards Summary for HDAC4 Gene

HDAC4 (Histone Deacetylase 4) is a Protein Coding gene. Diseases associated with HDAC4 include brachydactyly-mental retardation syndrome and 2q37 microdeletion syndrome. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is HDAC10.

UniProtKB/Swiss-Prot for HDAC4 Gene

  • Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Tocris Summary for HDAC4 Gene

  • Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.

Gene Wiki entry for HDAC4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDAC4 Gene

Genomics for HDAC4 Gene

Regulatory Elements for HDAC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HDAC4 Gene

Start:
239,048,168 bp from pter
End:
239,401,654 bp from pter
Size:
353,487 bases
Orientation:
Minus strand

Genomic View for HDAC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HDAC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDAC4 Gene

Proteins for HDAC4 Gene

  • Protein details for HDAC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56524-HDAC4_HUMAN
    Recommended name:
    Histone deacetylase 4
    Protein Accession:
    P56524
    Secondary Accessions:
    • E9PGB9
    • F5GX36
    • Q86YH7
    • Q9UND6

    Protein attributes for HDAC4 Gene

    Size:
    1084 amino acids
    Molecular mass:
    119040 Da
    Quaternary structure:
    • Interacts with HDAC7 (By similarity). Homodimer. Homodimerization via its N-terminal domain. Interacts with MEF2C, AHRR, and NR2C1. Interacts with a 14-3-3 chaperone protein in a phosphorylation dependent manner. Interacts with BTBD14B (By similarity). Interacts with KDM5B. Interacts with MYOCD (By similarity). Interacts with MORC2. Interacts with ANKRA2. Interacts with EP300 in the presence of TFAP2C.
    SequenceCaution:
    • Sequence=BAA22957.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HDAC4 Gene

    Alternative splice isoforms for HDAC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDAC4 Gene

Proteomics data for HDAC4 Gene at MOPED

Post-translational modifications for HDAC4 Gene

  • Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues by CaMK2D is required for the interaction with 14-3-3. Phosphorylation at Ser-350 impairs the binding of ANKRA2 but generates a high-affinity docking site for 14-3-3.
  • Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HDAC4 Gene

Antibody Products

  • R&D Systems Antibodies for HDAC4 (Histone Deacetylase 4/HDAC4)
  • Cell Signaling Technology (CST) Antibodies for HDAC4 (HDAC4)

Domains for HDAC4 Gene

Suggested Antigen Peptide Sequences for HDAC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56524

UniProtKB/Swiss-Prot:

HDAC4_HUMAN :
  • P56524
Domain:
  • The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm
Family:
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
genes like me logo Genes that share domains with HDAC4: view

No data available for Gene Families for HDAC4 Gene

Function for HDAC4 Gene

Molecular function for HDAC4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
UniProtKB/Swiss-Prot Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Enzyme Numbers (IUBMB) for HDAC4 Gene

Gene Ontology (GO) - Molecular Function for HDAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001025 RNA polymerase III transcription factor binding IPI 23867755
GO:0001047 core promoter binding IDA 24413532
GO:0003677 DNA binding --
GO:0003714 transcription corepressor activity IEA --
GO:0004407 histone deacetylase activity IDA 10220385
genes like me logo Genes that share ontologies with HDAC4: view
genes like me logo Genes that share phenotypes with HDAC4: view

Animal Models for HDAC4 Gene

MGI Knock Outs for HDAC4:

Animal Model Products

CRISPR Products

miRNA for HDAC4 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HDAC4

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for HDAC4 Gene

Localization for HDAC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDAC4 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HDAC4 Gene COMPARTMENTS Subcellular localization image for HDAC4 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HDAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IDA 11804585
GO:0005634 nucleus IDA 10869435
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with HDAC4: view

Pathways for HDAC4 Gene

genes like me logo Genes that share pathways with HDAC4: view

PCR Array Products

Gene Ontology (GO) - Biological Process for HDAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 18850004
GO:0001501 skeletal system development IEA --
GO:0002076 osteoblast development IEA --
GO:0006338 chromatin remodeling IDA 18850004
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HDAC4: view

Compounds for HDAC4 Gene

Compound Products

(5) Tocris Compounds for HDAC4 Gene

Compound Action Cas Number
FK 228 Potent and selective class I histone deacetylase inhibitor; antitumor [128517-07-7]
LMK 235 Selective HDAC4/HDAC5 inhibitor [1418033-25-6]
PCI 34051 Potent and selective histone deacetylase 8 (HDAC8) inhibitor; induces apoptosis in T cell-derived cell lines [950762-95-5]
SAHA Class I and II HDAC inhibitor [149647-78-9]
Trichostatin A Potent histone deacetylase inhibitor [58880-19-6]

(29) ApexBio Compounds for HDAC4 Gene

Compound Action Cas Number
AR-42 (OSU-HDAC42) Pan-HDAC inhibitor [935881-37-1]
Belinostat (PXD101) Novel and potent hydroxamate-type HDAC inhibitor [414864-00-9]
CI994 (Tacedinaline) HDAC1 and 3 inhibitor [112522-64-2]
CUDC-101 Multitargeted HDAC inhibitor [1012054-59-9]
CUDC-907 dual PI3K and HDAC inhibitor [1339928-25-4]
Droxinostat Selective HDAC inhibitor [99873-43-5]
Entinostat (MS-275,SNDX-275) Entinostat inhibits HDAC1 and HDAC3 but not HDAC8 [209783-80-2]
ITF2357 (Givinostat) HDAC inhibitor, inhibits class I and class II HDACs [732302-99-7]
JNJ-26481585 Potent pan-HDAC inhibitor [875320-29-9]
LAQ824 (NVP-LAQ824,Dacinostat) Novel and potent HDAC inhibitor [404951-53-7]
M344 Cell-permeable HDAC inhibitor [251456-60-7]
MC1568 Selective class IIa HDAC inhibitor [852475-26-4]
Mocetinostat (MGCD0103, MG0103) Class I selective HDAC inhibitor [726169-73-9]
Panobinostat (LBH589) Broad spectrum HDAC inhibitor, inhibits HDAC1-11 [404950-80-7]
PCI-24781 (CRA-024781) Novel pan-HDAC inhibitor [783355-60-2]
PCI-34051 Potent, specific HDAC8 inhibitor [950762-95-5]
Pracinostat (SB939) Pan-HDAC inhibitor, inhibits all HDAC isozymes except HDAC6 and HDAC7 [929016-96-6]
Resminostat (RAS2410) Potent inhibitor of HDAC classes I and II [864814-88-0]
RG2833 Brain-penetrant HDAC inhibitor [1215493-56-3]
RGFP966 Specific HDAC3 inhibitor [1396841-57-8]
Rocilinostat (ACY-1215) Selective HDAC6 inhibitor [1316214-52-4]
Romidepsin (FK228, depsipeptide) Potent HDAC1 and HDAC2 inhibitor [128517-07-7]
Scriptaid Cell-permeable HDAC inhibitor [287383-59-9]
Trichostatin A (TSA) Cell-permeable, non-competitive, and reversible HDAC inhibitor [58880-19-6]
Tubacin Selective HDAC6 inhibitor [1350555-93-9]
Tubastatin A Potent and selective HDAC6 inhibitor [1252003-15-8]
Tubastatin A HCl Potent and selective HDAC6 inhibitor [1310693-92-5]
Valproic acid sodium salt HDAC inhibitor [1069-66-5]
Vorinostat (SAHA, MK0683) Class I and II HDAC inhibitor [149647-78-9]

(1) HMDB Compounds for HDAC4 Gene

Compound Synonyms Cas Number PubMed IDs
Butyric acid
  • 1-Butyrate
107-92-6

(10) Novoseek inferred chemical compound relationships for HDAC4 Gene

Compound -log(P) Hits PubMed IDs
trapoxin 78 1
lysine 43.1 2
threonine 35.3 1
serine 29.1 3
butyrate 20 1
genes like me logo Genes that share compounds with HDAC4: view

Transcripts for HDAC4 Gene

Unigene Clusters for HDAC4 Gene

Histone deacetylase 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HDAC4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HDAC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDAC4 Gene

No ASD Table

Relevant External Links for HDAC4 Gene

GeneLoc Exon Structure for
HDAC4
ECgene alternative splicing isoforms for
HDAC4

Expression for HDAC4 Gene

mRNA expression in normal human tissues for HDAC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HDAC4 Gene

This gene is overexpressed in Muscle - Skeletal (7.1) and Colon - Sigmoid (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HDAC4 Gene

SOURCE GeneReport for Unigene cluster for HDAC4 Gene Hs.20516

mRNA Expression by UniProt/SwissProt for HDAC4 Gene

P56524-HDAC4_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with HDAC4: view

In Situ Assay Products

Orthologs for HDAC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HDAC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDAC4 35
  • 99.42 (n)
  • 99.54 (a)
HDAC4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HDAC4 35
  • 88.18 (n)
  • 92.54 (a)
HDAC4 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HDAC4 35
  • 88.96 (n)
  • 93.26 (a)
HDAC4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hdac4 35
  • 86.43 (n)
  • 94.45 (a)
Hdac4 16
Hdac4 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HDAC4 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HDAC4 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hdac4 35
  • 86.48 (n)
  • 94.18 (a)
chicken
(Gallus gallus)
Aves HDAC4 35
  • 81.51 (n)
  • 91.1 (a)
HDAC4 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HDAC4 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdac4 35
  • 71.46 (n)
  • 82.11 (a)
zebrafish
(Danio rerio)
Actinopterygii hdac4 35
  • 75.71 (n)
  • 81.01 (a)
hdac4 36
  • 81 (a)
OneToOne
wufc56f08 35
fruit fly
(Drosophila melanogaster)
Insecta HDAC4 36
  • 33 (a)
OneToMany
HDAC4 37
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea hda-4 36
  • 34 (a)
OneToMany
hda-4 37
  • 50 (a)
F43G6.4 37
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HDA1 36
  • 11 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.21399 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
ManyToMany
CSA.5129 36
  • 31 (a)
ManyToMany
Species with no ortholog for HDAC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDAC4 Gene

ENSEMBL:
Gene Tree for HDAC4 (if available)
TreeFam:
Gene Tree for HDAC4 (if available)

Paralogs for HDAC4 Gene

Paralogs for HDAC4 Gene

genes like me logo Genes that share paralogs with HDAC4: view

Variants for HDAC4 Gene

Sequence variations from dbSNP and Humsavar for HDAC4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3683 -- 239,048,749(+) AGAAC(A/C)CGCTC utr-variant-3-prime
rs169731 -- 239,230,401(+) GCAGG(C/T)GACAT intron-variant
rs172365 -- 239,230,446(+) TTGCC(C/T)GTGGC intron-variant
rs291329 -- 239,222,726(+) GCAAT(C/T)GAATA intron-variant
rs291330 -- 239,223,207(+) GGGCC(A/G)AAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDAC4 Gene

Variant ID Type Subtype PubMed ID
nsv876071 CNV Loss 21882294
nsv834578 CNV Loss 17160897
dgv4462n71 CNV Loss 21882294
nsv876074 CNV Loss 21882294
nsv876075 CNV Loss 21882294
nsv876077 CNV Loss 21882294
nsv876079 CNV Loss 21882294
nsv818118 CNV Gain 17921354
nsv834579 CNV Loss 17160897
nsv876080 CNV Loss 21882294
nsv508896 CNV Insertion 20534489
esv2721800 CNV Deletion 23290073
esv2721801 CNV Deletion 23290073
nsv834581 CNV Loss 17160897
nsv3234 CNV Insertion 18451855
esv2672769 CNV Deletion 23128226
esv2721802 CNV Deletion 23290073
nsv460148 CNV Loss 19166990
esv2721803 CNV Deletion 23290073
esv2721804 CNV Deletion 23290073
esv2721805 CNV Deletion 23290073
esv2721808 CNV Deletion 23290073
esv2721809 CNV Deletion 23290073
nsv876081 CNV Loss 21882294
nsv428409 CNV Gain 18775914
esv2721810 CNV Deletion 23290073
esv2721811 CNV Deletion 23290073
esv22351 CNV Loss 19812545
esv2721812 CNV Deletion 23290073
esv1680698 CNV Insertion 17803354
nsv214049 CNV Insertion 16902084
esv2721813 CNV Deletion 23290073
dgv4463n71 CNV Loss 21882294
esv1671397 CNV Insertion 17803354
esv2721814 CNV Deletion 23290073
esv2721815 CNV Deletion 23290073
nsv876085 CNV Loss 21882294
dgv4464n71 CNV Loss 21882294
dgv4465n71 CNV Loss 21882294
nsv876090 CNV Loss 21882294
esv2721816 CNV Deletion 23290073
esv2721817 CNV Deletion 23290073
nsv834582 CNV Loss 17160897
esv2721819 CNV Deletion 23290073
esv2721820 CNV Deletion 23290073
esv2721821 CNV Deletion 23290073
nsv876091 CNV Loss 21882294
dgv683e201 CNV Deletion 23290073
esv5174 CNV Deletion 18987735
esv1755219 CNV Deletion 17803354
dgv684e201 CNV Deletion 23290073
esv2721825 CNV Deletion 23290073
esv1007259 CNV Deletion 20482838
esv2721827 CNV Deletion 23290073
esv1561814 CNV Deletion 17803354
esv2721828 CNV Deletion 23290073
esv2721830 CNV Deletion 23290073
esv2721831 CNV Deletion 23290073
esv26350 CNV Loss 19812545
esv2105474 CNV Deletion 18987734
esv2667661 CNV Deletion 23128226
esv2721832 CNV Deletion 23290073
esv2673598 CNV Deletion 23128226
esv2674841 CNV Deletion 23128226
esv2659908 CNV Deletion 23128226
esv2721833 CNV Deletion 23290073
esv2668246 CNV Deletion 23128226
dgv689n67 CNV Gain 20364138
esv23834 CNV Loss 19812545

Relevant External Links for HDAC4 Gene

HapMap Linkage Disequilibrium report
HDAC4
Human Gene Mutation Database (HGMD)
HDAC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDAC4 Gene

Disorders for HDAC4 Gene

(1) OMIM Diseases for HDAC4 Gene (605314)

UniProtKB/Swiss-Prot

HDAC4_HUMAN
  • Brachydactyly-mental retardation syndrome (BDMR) [MIM:600430]: A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism. {ECO:0000269 PubMed:20691407}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for HDAC4 Gene

(5) Novoseek inferred disease relationships for HDAC4 Gene

Disease -log(P) Hits PubMed IDs
cardiac hypertrophy 34.8 3
hypertrophy 29.2 6
cancer 16.5 10
tumors 15.4 13
leukemia 13.2 2

Relevant External Links for HDAC4

Genetic Association Database (GAD)
HDAC4
Human Genome Epidemiology (HuGE) Navigator
HDAC4
genes like me logo Genes that share disorders with HDAC4: view

Publications for HDAC4 Gene

  1. Three proteins define a class of human histone deacetylases related to yeast Hda1p. (PMID: 10220385) Grozinger C.M. … Schreiber S.L. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23
  2. HDAC4 deacetylase associates with and represses the MEF2 transcription factor. (PMID: 10487761) Miska E.A. … Kouzarides T. (EMBO J. 1999) 3 4 23
  3. HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. (PMID: 10523670) Wang A.H. … Yang X.-J. (Mol. Cell. Biol. 1999) 3 4 23
  4. The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking. (PMID: 11470791) Zhao X. … Yao T.-P. (J. Biol. Chem. 2001) 3 4 23
  5. Regulation of histone deacetylase 4 by binding of 14-3-3 proteins. (PMID: 10958686) Wang A.H. … Yang X.-J. (Mol. Cell. Biol. 2000) 3 4 23

Products for HDAC4 Gene

  • Addgene plasmids for HDAC4

Sources for HDAC4 Gene

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