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Aliases for HDAC2 Gene

Aliases for HDAC2 Gene

  • Histone Deacetylase 2 2 3
  • EC 3.5.1.98 4 64
  • HD2 3 4
  • Transcriptional Regulator Homolog RPD3 3
  • YY1-Associated Factor 1 3
  • RPD3 3
  • YAF1 3

External Ids for HDAC2 Gene

Summaries for HDAC2 Gene

Entrez Gene Summary for HDAC2 Gene

  • This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

GeneCards Summary for HDAC2 Gene

HDAC2 (Histone Deacetylase 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is HDAC8.

UniProtKB/Swiss-Prot for HDAC2 Gene

  • Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Tocris Summary for HDAC2 Gene

  • Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.

Gene Wiki entry for HDAC2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDAC2 Gene

Genomics for HDAC2 Gene

Genomic Location for HDAC2 Gene

Start:
113,933,028 bp from pter
End:
114,011,308 bp from pter
Size:
78,281 bases
Orientation:
Minus strand

Genomic View for HDAC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HDAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDAC2 Gene

Regulatory Elements for HDAC2 Gene

Proteins for HDAC2 Gene

  • Protein details for HDAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92769-HDAC2_HUMAN
    Recommended name:
    Histone deacetylase 2
    Protein Accession:
    Q92769
    Secondary Accessions:
    • B3KRS5
    • B4DL58
    • E1P561
    • Q5SRI8
    • Q5SZ86
    • Q8NEH4

    Protein attributes for HDAC2 Gene

    Size:
    488 amino acids
    Molecular mass:
    55364 Da
    Quaternary structure:
    • Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a RCOR/GFI/KDM1A/HDAC complex. Interacts directly with GFI1 and GFI1B. Interacts with SNW1, HDAC7, PRDM6, SAP30, SETDB1 and SUV39H1. Interacts with the H2AFY (via the non-histone region). Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B, KDM1A, RCOR1 and PHF21A. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Part of a complex containing the core histones H2A, H2B, H3 and H4, DEK and unphosphorylated DAXX. Part of a complex containing ATR and CHD4. Forms a heterologous complex at least with YY1. Interacts with ATR, CBFA2T3, DNMT1, MINT, HDAC10, HCFC1, NRIP1, KDM4A and PELP1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3, ARID4B, HDAC1 and HDAC2. Interacts with CHFR and SAP30L. Interacts (CK2 phosphorylated form) with SP3. Interacts with TSHZ3 (via its N-terminus). Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. Interacts with FAM64A. Interacts with BCL6 (non-acetylated form). Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2. Interacts with CRY1, INSM1 and ZNF431. Interacts with NACC2. Interacts with MTA1, with a preference for sumoylated MTA1. Interacts with SIX3 (By similarity).
    SequenceCaution:
    • Sequence=AAH31055.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG59420.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HDAC2 Gene

    Alternative splice isoforms for HDAC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDAC2 Gene

Proteomics data for HDAC2 Gene at MOPED

Post-translational modifications for HDAC2 Gene

  • S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys-262 and Cys-274 does not affect the enzyme activity but abolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated with neuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching. S-Nitrosylation interferes with its interaction with MTA1 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys11, Lys67, Lys75, Lys90, Lys201, Lys243, Lys284, and Lys362

Domains for HDAC2 Gene

UniProtKB/Swiss-Prot:

HDAC2_HUMAN
Family:
  • Belongs to the histone deacetylase family. HD type 1 subfamily.:
    • Q92769
genes like me logo Genes that share domains with HDAC2: view

No data available for Gene Families for HDAC2 Gene

Function for HDAC2 Gene

Molecular function for HDAC2 Gene

GENATLAS Biochemistry: histone deacetyltransferase 2,ubiquitously expressed,binding to YY1 for negative regulation of transcription,modulator of chromatin structure
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
UniProtKB/Swiss-Prot Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Enzyme Numbers (IUBMB) for HDAC2 Gene

Gene Ontology (GO) - Molecular Function for HDAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16217013
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA 16217013
GO:0001047 core promoter binding IEA --
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 22926524
GO:0003682 chromatin binding ISS --
genes like me logo Genes that share ontologies with HDAC2: view
genes like me logo Genes that share phenotypes with HDAC2: view

Animal Models for HDAC2 Gene

MGI Knock Outs for HDAC2:

miRNA for HDAC2 Gene

miRTarBase miRNAs that target HDAC2

No data available for Transcription Factor Targeting and HOMER Transcription for HDAC2 Gene

Localization for HDAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDAC2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HDAC2 Gene COMPARTMENTS Subcellular localization image for HDAC2 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2
endoplasmic reticulum 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HDAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin --
GO:0000790 nuclear chromatin IDA 16217013
GO:0000792 heterochromatin IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HDAC2: view

Pathways for HDAC2 Gene

genes like me logo Genes that share pathways with HDAC2: view

Gene Ontology (GO) - Biological Process for HDAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19041327
GO:0006325 chromatin organization TAS --
GO:0006338 chromatin remodeling IC 17827154
GO:0006344 maintenance of chromatin silencing IMP 19372552
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HDAC2: view

Compounds for HDAC2 Gene

(29) ApexBio Compounds for HDAC2 Gene

Compound Action Cas Number
AR-42 (OSU-HDAC42) Pan-HDAC inhibitor [935881-37-1]
Belinostat (PXD101) Novel and potent hydroxamate-type HDAC inhibitor [414864-00-9]
CI994 (Tacedinaline) HDAC1 and 3 inhibitor [112522-64-2]
CUDC-101 Multitargeted HDAC inhibitor [1012054-59-9]
CUDC-907 dual PI3K and HDAC inhibitor [1339928-25-4]
Droxinostat Selective HDAC inhibitor [99873-43-5]
Entinostat (MS-275,SNDX-275) Entinostat inhibits HDAC1 and HDAC3 but not HDAC8 [209783-80-2]
ITF2357 (Givinostat) HDAC inhibitor, inhibits class I and class II HDACs [732302-99-7]
JNJ-26481585 Potent pan-HDAC inhibitor [875320-29-9]
LAQ824 (NVP-LAQ824,Dacinostat) Novel and potent HDAC inhibitor [404951-53-7]
M344 Cell-permeable HDAC inhibitor [251456-60-7]
MC1568 Selective class IIa HDAC inhibitor [852475-26-4]
Mocetinostat (MGCD0103, MG0103) Class I selective HDAC inhibitor [726169-73-9]
Panobinostat (LBH589) Broad spectrum HDAC inhibitor, inhibits HDAC1-11 [404950-80-7]
PCI-24781 (CRA-024781) Novel pan-HDAC inhibitor [783355-60-2]
PCI-34051 Potent, specific HDAC8 inhibitor [950762-95-5]
Pracinostat (SB939) Pan-HDAC inhibitor, inhibits all HDAC isozymes except HDAC6 and HDAC7 [929016-96-6]
Resminostat (RAS2410) Potent inhibitor of HDAC classes I and II [864814-88-0]
RG2833 Brain-penetrant HDAC inhibitor [1215493-56-3]
RGFP966 Specific HDAC3 inhibitor [1396841-57-8]
Rocilinostat (ACY-1215) Selective HDAC6 inhibitor [1316214-52-4]
Romidepsin (FK228, depsipeptide) Potent HDAC1 and HDAC2 inhibitor [128517-07-7]
Scriptaid Cell-permeable HDAC inhibitor [287383-59-9]
Trichostatin A (TSA) Cell-permeable, non-competitive, and reversible HDAC inhibitor [58880-19-6]
Tubacin Selective HDAC6 inhibitor [1350555-93-9]
Tubastatin A Potent and selective HDAC6 inhibitor [1252003-15-8]
Tubastatin A HCl Potent and selective HDAC6 inhibitor [1310693-92-5]
Valproic acid sodium salt HDAC inhibitor [1069-66-5]
Vorinostat (SAHA, MK0683) Class I and II HDAC inhibitor [149647-78-9]

(5) Tocris Compounds for HDAC2 Gene

Compound Action Cas Number
LMK 235 Selective HDAC4/HDAC5 inhibitor [1418033-25-6]
Sodium 4-Phenylbutyrate Histone deacetylase inhibitor [1716-12-7]
TCS HDAC6 20b Selective HDAC6 inhibitor [956154-63-5]
Trichostatin A Histone deacetylase inhibitor [58880-19-6]
Tubacin HDAC6 inhibitor; inhibits alpha-tubulin deacetylation [1350555-93-9]

(1) HMDB Compounds for HDAC2 Gene

Compound Synonyms Cas Number PubMed IDs
Butyric acid
  • 1-Butyrate
107-92-6

(5) Drugbank Compounds for HDAC2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aminophylline
  • Aminophyllin
317-34-0 target activator
Lovastatin
  • 6 alpha-Methylcompactin
75330-75-5 target other
Oxtriphylline
  • Choline theophyllinate
4499-40-5 target activator
Theophylline
  • Dimethylxanthine
58-55-9 target activator
Vorinostat
  • MK0683
149647-78-9 target inhibitor

(25) Novoseek inferred chemical compound relationships for HDAC2 Gene

Compound -log(P) Hits PubMed IDs
suberoylanilide hydroxamic acid 71.4 2
valproic acid 57.3 7
butyrate 52.9 1
depsipeptide 48.8 1
theophylline 48.6 3
genes like me logo Genes that share compounds with HDAC2: view

Transcripts for HDAC2 Gene

Unigene Clusters for HDAC2 Gene

Histone deacetylase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HDAC2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - -
SP5: - -
SP6: -
SP7: - - -
SP8: - - - - - - -

Relevant External Links for HDAC2 Gene

GeneLoc Exon Structure for
HDAC2
ECgene alternative splicing isoforms for
HDAC2

Expression for HDAC2 Gene

mRNA expression in normal human tissues for HDAC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HDAC2 Gene

SOURCE GeneReport for Unigene cluster for HDAC2 Gene Hs.3352

mRNA Expression by UniProt/SwissProt for HDAC2 Gene

Q92769-HDAC2_HUMAN
Tissue specificity: Widely expressed; lower levels in brain and lung
genes like me logo Genes that share expressions with HDAC2: view

Orthologs for HDAC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HDAC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDAC2 36
  • 99.86 (n)
  • 100 (a)
HDAC2 37
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HDAC2 36
  • 93.99 (n)
  • 99.39 (a)
HDAC2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HDAC2 36
  • 94.39 (n)
  • 98.95 (a)
HDAC2 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hdac2 36
  • 91.6 (n)
  • 99.59 (a)
Hdac2 16
Hdac2 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HDAC2 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HDAC2 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hdac2 36
  • 89.69 (n)
  • 98.98 (a)
chicken
(Gallus gallus)
Aves HDAC2 36
  • 85.66 (n)
  • 98.16 (a)
HDAC2 37
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HDAC2 37
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25023 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hdac2 36
  • 82.65 (n)
  • 97.34 (a)
zebrafish
(Danio rerio)
Actinopterygii hdac1 36
  • 75.49 (n)
  • 89.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rpd3 37
  • 71 (a)
OneToMany
HDAC3 38
  • 57 (a)
Rpd3 38
  • 79 (a)
worm
(Caenorhabditis elegans)
Secernentea hda-1 36
  • 62.86 (n)
  • 65.32 (a)
hda-1 37
  • 64 (a)
ManyToMany
hda-3 37
  • 60 (a)
ManyToMany
hda-1 38
  • 64 (a)
hda-2 38
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPD3 37
  • 60 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11399 36
thale cress
(Arabidopsis thaliana)
eudicotyledons HDA6 36
  • 61.5 (n)
  • 65.75 (a)
rice
(Oryza sativa)
Liliopsida Os08g0344100 36
  • 58.87 (n)
  • 60.34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3554 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10476 37
  • 82 (a)
OneToMany
Species with no ortholog for HDAC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDAC2 Gene

ENSEMBL:
Gene Tree for HDAC2 (if available)
TreeFam:
Gene Tree for HDAC2 (if available)

Paralogs for HDAC2 Gene

Paralogs for HDAC2 Gene

Pseudogenes.org Pseudogenes for HDAC2 Gene

genes like me logo Genes that share paralogs with HDAC2: view

Variants for HDAC2 Gene

Sequence variations from dbSNP and Humsavar for HDAC2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs11391 -- 113,940,851(-) CACCA(G/T)GCTTT utr-variant-3-prime, nc-transcript-variant
rs352061 -- 113,942,321(-) TCCCA(A/G)TGTAT intron-variant
rs352062 -- 113,944,590(-) GAGTT(C/T)GAGGC intron-variant
rs352063 -- 113,951,963(-) GTGAT(C/G)CTAGT intron-variant
rs352068 -- 113,940,688(-) ACAAT(A/G)TGAAG utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for HDAC2 Gene

Variant ID Type Subtype PubMed ID
esv2732596 CNV Deletion 23290073
nsv520419 CNV Loss 19592680

Relevant External Links for HDAC2 Gene

HapMap Linkage Disequilibrium report
HDAC2

Disorders for HDAC2 Gene

(3) University of Copenhagen DISEASES for HDAC2 Gene

(22) Novoseek inferred disease relationships for HDAC2 Gene

Disease -log(P) Hits PubMed IDs
pulmonary disease chronic obstructive 60.8 12
colon cancer 40.4 11
asthma 39.2 16
cancer 32.2 16
inflammation 32.1 20

Relevant External Links for HDAC2

Genetic Association Database (GAD)
HDAC2
Human Genome Epidemiology (HuGE) Navigator
HDAC2
genes like me logo Genes that share disorders with HDAC2: view

No data available for UniProtKB/Swiss-Prot for HDAC2 Gene

Publications for HDAC2 Gene

  1. Human histone deacetylase 2, HDAC2 (Human RPD3), is localized to 6q21 by radiation hybrid mapping. (PMID: 9782097) Betz R. … EkstrAPm T.J. (Genomics 1998) 2 3 23
  2. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. (PMID: 10888872) Rountree M.R. … Baylin S.B. (Nat. Genet. 2000) 3 4 23
  3. Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. (PMID: 10545197) Schmidt D.R. … Schreiber S.L. (Biochemistry 1999) 3 4 23
  4. The transcriptional repressor Sp3 is associated with CK2- phosphorylated histone deacetylase 2. (PMID: 12176973) Sun J.M. … Davie J.R. (J. Biol. Chem. 2002) 3 4 23
  5. The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. (PMID: 11564889) Ashburner B.P. … Baldwin A.S. (Mol. Cell. Biol. 2001) 3 23

Products for HDAC2 Gene

Sources for HDAC2 Gene

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