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Aliases for HDAC2 Gene

Aliases for HDAC2 Gene

  • Histone Deacetylase 2 2 3 5
  • EC 3.5.1.98 4 61
  • HD2 3 4
  • Transcriptional Regulator Homolog RPD3 3
  • YY1-Associated Factor 1 3
  • RPD3 3
  • YAF1 3

External Ids for HDAC2 Gene

Previous GeneCards Identifiers for HDAC2 Gene

  • GC06M114097
  • GC06M114284
  • GC06M114307
  • GC06M114368
  • GC06M111834
  • GC06M114254

Summaries for HDAC2 Gene

Entrez Gene Summary for HDAC2 Gene

  • This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

GeneCards Summary for HDAC2 Gene

HDAC2 (Histone Deacetylase 2) is a Protein Coding gene. Diseases associated with HDAC2 include Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant and Rett Syndrome. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and PEDF Induced Signaling. GO annotations related to this gene include poly(A) RNA binding and sequence-specific DNA binding. An important paralog of this gene is HDAC1.

UniProtKB/Swiss-Prot for HDAC2 Gene

  • Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Tocris Summary for HDAC2 Gene

  • Histone deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze acetyl group removal from lysine residues in histones and non-histone proteins, causing transcriptional repression. HDACs are usually components of multiprotein complexes.

Gene Wiki entry for HDAC2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDAC2 Gene

Genomics for HDAC2 Gene

Regulatory Elements for HDAC2 Gene

Enhancers for HDAC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G113646 1.7 Ensembl ENCODE dbSUPER 22.7 +362.4 362437 4.3 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF263 SP3 HDAC2 RPS27AP11 LOC101927686 GC06P113618
GH06G113854 2.8 FANTOM5 ENCODE dbSUPER 10.5 +153.5 153488 7.5 HDGF PKNOX1 FOXA2 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YBX1 FLJ34503 RPS27AP11 HDAC2 MARCKS GC06P113861
GH06G113495 1.1 Ensembl ENCODE 26.4 +515.3 515303 2.3 ZFP64 RAD21 ZEB1 GATA2 FOS ZNF202 ZBTB11 ZNF426 TSHZ1 ZEB2 HDAC2 RPS27AP11 GC06P113526 LINC02518
GH06G113629 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +378.8 378808 7.0 HDGF PKNOX1 FOXA2 WRNIP1 SIN3A GATA2 ZNF143 ZNF207 FOS JUNB LOC101927686 HDAC2 MARCKS GC06P113618
GH06G113446 1.4 FANTOM5 Ensembl ENCODE 14.8 +562.3 562322 4.8 FOXA2 JUN CEBPG RAD21 FOSL1 ZSCAN5C SCRT2 FOSL2 FOS MAFK HDAC2 RPS27AP11 MARCKS LINC02518 GC06P113526
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HDAC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HDAC2 Gene

Chromosome:
6
Start:
113,933,028 bp from pter
End:
114,011,308 bp from pter
Size:
78,281 bases
Orientation:
Minus strand

Genomic View for HDAC2 Gene

Genes around HDAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDAC2 Gene

Proteins for HDAC2 Gene

  • Protein details for HDAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92769-HDAC2_HUMAN
    Recommended name:
    Histone deacetylase 2
    Protein Accession:
    Q92769
    Secondary Accessions:
    • B3KRS5
    • B4DL58
    • E1P561
    • Q5SRI8
    • Q5SZ86
    • Q8NEH4

    Protein attributes for HDAC2 Gene

    Size:
    488 amino acids
    Molecular mass:
    55364 Da
    Quaternary structure:
    • Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a RCOR/GFI/KDM1A/HDAC complex. Interacts directly with GFI1 and GFI1B. Interacts with SNW1, HDAC7, PRDM6, SAP30, SETDB1 and SUV39H1. Interacts with the H2AFY (via the non-histone region). Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B, KDM1A, RCOR1 and PHF21A. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Part of a complex containing the core histones H2A, H2B, H3 and H4, DEK and unphosphorylated DAXX. Part of a complex containing ATR and CHD4. Forms a heterologous complex at least with YY1. Interacts with ATR, CBFA2T3, DNMT1, MINT, HDAC10, HCFC1, NRIP1, KDM4A and PELP1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3, ARID4B, HDAC1 and HDAC2. Interacts with CHFR and SAP30L. Interacts (CK2 phosphorylated form) with SP3. Interacts with TSHZ3 (via its N-terminus). Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. Interacts with FAM64A. Interacts with BCL6 (non-acetylated form). Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2. Interacts with CRY1, INSM1 and ZNF431. Interacts with NACC2. Interacts with MTA1, with a preference for sumoylated MTA1. Interacts with SIX3 (By similarity). Interacts with BEND3. Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2 (PubMed:21573134).
    SequenceCaution:
    • Sequence=AAH31055.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG59420.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HDAC2 Gene

    Alternative splice isoforms for HDAC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDAC2 Gene

Selected DME Specific Peptides for HDAC2 Gene

Q92769:
  • AVVLQCG
  • RLFENLRMLPHAPGVQ
  • HHGDGVEEAFY
  • DIGAGKGK
  • KVMEMYQPSA
  • HPMKPHR
  • DIDIHHGDGV
  • LNYGLYR
  • GGLHHAKK
  • GGSVAGAVKLN
  • IRPDNMSEY
  • KVCYYYDGD
  • DRLGCFNL
  • RCWTYET
  • NELPYNDYFEYFGPDFKLHISPSNMTNQNT
  • QCGADSL
  • PDKRISI
  • DGIDDESY
  • KGHAKCVE
  • LELLKYH
  • AVKLNRQ
  • SDKRIAC
  • GGGGYTIRNV
  • DRVMTVSFH
  • FNVGEDCP
  • VSFHKYG
  • RVLYIDID
  • GEYFPGTG

Post-translational modifications for HDAC2 Gene

  • S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys-262 and Cys-274 does not affect the enzyme activity but abolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated with neuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching. S-Nitrosylation interferes with its interaction with MTA1 (By similarity).
  • Ubiquitination at posLast=1111, isoforms=375, isoforms=3243, and posLast=284284
  • Modification sites at PhosphoSitePlus

Domains & Families for HDAC2 Gene

Suggested Antigen Peptide Sequences for HDAC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92769

UniProtKB/Swiss-Prot:

HDAC2_HUMAN :
  • Belongs to the histone deacetylase family. HD type 1 subfamily.
Family:
  • Belongs to the histone deacetylase family. HD type 1 subfamily.
genes like me logo Genes that share domains with HDAC2: view

Function for HDAC2 Gene

Molecular function for HDAC2 Gene

GENATLAS Biochemistry:
histone deacetyltransferase 2,ubiquitously expressed,binding to YY1 for negative regulation of transcription,modulator of chromatin structure
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
UniProtKB/Swiss-Prot Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Enzyme Numbers (IUBMB) for HDAC2 Gene

Gene Ontology (GO) - Molecular Function for HDAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16217013
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA 16217013
GO:0001047 core promoter binding IEA --
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 22926524
GO:0003682 chromatin binding ISS --
genes like me logo Genes that share ontologies with HDAC2: view
genes like me logo Genes that share phenotypes with HDAC2: view

Animal Models for HDAC2 Gene

MGI Knock Outs for HDAC2:

Animal Model Products

  • Taconic Biosciences Mouse Models for HDAC2

CRISPR Products

miRNA for HDAC2 Gene

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HDAC2 Gene

Localization for HDAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDAC2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDAC2 gene
Compartment Confidence
nucleus 5
mitochondrion 3
endoplasmic reticulum 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HDAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0000790 nuclear chromatin IDA 16217013
GO:0005634 nucleus IEA,IDA 18347167
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 12711221
genes like me logo Genes that share ontologies with HDAC2: view

Pathways & Interactions for HDAC2 Gene

SuperPathways for HDAC2 Gene

genes like me logo Genes that share pathways with HDAC2: view

SIGNOR curated interactions for HDAC2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for HDAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19041327
GO:0001975 response to amphetamine IEA --
GO:0003300 cardiac muscle hypertrophy IEA --
GO:0006338 chromatin remodeling IC 17827154
GO:0006344 maintenance of chromatin silencing IMP 19372552
genes like me logo Genes that share ontologies with HDAC2: view

Drugs & Compounds for HDAC2 Gene

(75) Drugs for HDAC2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vorinostat Approved, Investigational Pharma inhibitor, Target HDAC inhibitor, Histone deacetylase (HDAC)inhibitors 247
Romidepsin Approved, Investigational Pharma inhibitor, Target, antagonist Histone deacetylase (HDAC)inhibitors 87
Valproic Acid Approved, Investigational Pharma inhibitor, Target HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 327
Lovastatin Approved, Investigational Pharma Competitive, Inhibitor, Target, other HMG-CoA reductase inhibitor, Potent HMG-CoA reductase inhibitor 63
Sodium phenylbutyrate Approved Pharma Inhibitor Histone deacetylase inhibitor, Histone deacetylase (HDAC)inhibitors 0

(12) Additional Compounds for HDAC2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FK 228
128517-07-7
MC 1742
1776116-74-5
SAHA
149647-78-9

(5) Tocris Compounds for HDAC2 Gene

Compound Action Cas Number
FK 228 Potent and selective class I histone deacetylase inhibitor; antitumor 128517-07-7
MC 1568 Selective HDAC class II (IIa) inhibitor 852475-26-4
MC 1742 Potent class I and IIb HDAC inhibitor 1776116-74-5
SAHA Class I and II HDAC inhibitor 149647-78-9
Trichostatin A Potent histone deacetylase inhibitor 58880-19-6

(31) ApexBio Compounds for HDAC2 Gene

Compound Action Cas Number
2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor 96017-59-3
4SC-202 Class I HDAC inhibitor 1186222-89-8
AR-42 (OSU-HDAC42) HDAC inhibitor,novel and potent 935881-37-1
Belinostat (PXD101) Hydroxamate-type HDAC inhibitor 414864-00-9
BML-210(CAY10433) Novel HDAC inhibitor 537034-17-6
BMS-345541(free base) IKK-1/IKK-2 inhibitor,potent and selective 445430-58-0
Chidamide Novel HDAC inhibitor 743420-02-2
CUDC-907 Potent PI3K/HDAC inhibitor 1339928-25-4
Droxinostat Selective HDAC inhibitor 99873-43-5
HDAC Set I
HPOB HDAC6 inhibitor, potent and selective 1429651-50-2
ITF2357 (Givinostat) HDAC inhibitor 732302-99-7
JNJ-26481585 Potent HDAC inhibitor 875320-29-9
LAQ824 (NVP-LAQ824,Dacinostat) HDAC inhibitor,potent and novel 404951-53-7
M344 HDAC inhibitor,potent and cell-permeable 251456-60-7
Mocetinostat (MGCD0103, MG0103) HDAC inhibitor,isotype-selective and potent 726169-73-9
NCH 51 Histone deacetylase (HDAC) inhibitor 848354-66-5
NSC 3852 HDAC inhibitor 3565-26-2
Panobinostat (LBH589) HDAC inhibitor 404950-80-7
Parthenolide 20554-84-1
PCI-24781 (CRA-024781) Pan-HDAC inhibitor 783355-60-2
Romidepsin (FK228, depsipeptide) HDAC1/HDAC2 inhibitor,potent and selective 128517-07-7
Santacruzamate A (CAY10683) 1477949-42-0
Sodium Phenylbutyrate Histone deacetylase inhibitor 1716-12-7
Suberohydroxamic Acid HDAC inhibitor 38937-66-5
TC-H 106 HDAC inhibitor 937039-45-7
Trichostatin A (TSA) HDAC inhibitor 58880-19-6
Tubacin HDAC6 inhibitor,potent,selective,reversible,cell-permeable 1350555-93-9
UF 010 Novel and selective class I HDAC inhibitor 537672-41-6
Valproic acid sodium salt (Sodium valproate) HDAC inhibitor 1069-66-5
Vorinostat (SAHA, MK0683) HDAC inhibitor 149647-78-9
genes like me logo Genes that share compounds with HDAC2: view

Drug Products

Transcripts for HDAC2 Gene

Unigene Clusters for HDAC2 Gene

Histone deacetylase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HDAC2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - -
SP5: - -
SP6: -
SP7: - - -
SP8: - - - - - - -

Relevant External Links for HDAC2 Gene

GeneLoc Exon Structure for
HDAC2
ECgene alternative splicing isoforms for
HDAC2

Expression for HDAC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HDAC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HDAC2 Gene

This gene is overexpressed in Lavage (10.6) and Fetal ovary (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HDAC2 Gene



Protein tissue co-expression partners for HDAC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HDAC2 Gene:

HDAC2

SOURCE GeneReport for Unigene cluster for HDAC2 Gene:

Hs.3352

mRNA Expression by UniProt/SwissProt for HDAC2 Gene:

Q92769-HDAC2_HUMAN
Tissue specificity: Widely expressed; lower levels in brain and lung.

Evidence on tissue expression from TISSUES for HDAC2 Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Lung(3.3)
  • Intestine(3.1)
  • Muscle(3.1)
  • Heart(3)
  • Skin(2.8)
  • Kidney(2.7)
  • Lymph node(2.7)
  • Bone marrow(2.6)
  • Blood(2.4)
  • Adrenal gland(2.3)
  • Pancreas(2.3)
  • Spleen(2.3)
  • Stomach(2.3)
  • Thyroid gland(2.3)
genes like me logo Genes that share expression patterns with HDAC2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDAC2 Gene

Orthologs for HDAC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HDAC2 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia HDAC2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HDAC2 34 35
  • 99.86 (n)
oppossum
(Monodelphis domestica)
Mammalia HDAC2 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HDAC2 34 35
  • 94.39 (n)
cow
(Bos Taurus)
Mammalia HDAC2 34 35
  • 93.99 (n)
mouse
(Mus musculus)
Mammalia Hdac2 34 16 35
  • 91.6 (n)
rat
(Rattus norvegicus)
Mammalia Hdac2 34
  • 89.69 (n)
chicken
(Gallus gallus)
Aves HDAC2 34 35
  • 85.66 (n)
lizard
(Anolis carolinensis)
Reptilia HDAC2 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdac2 34
  • 82.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25023 34
zebrafish
(Danio rerio)
Actinopterygii hdac1 34
  • 75.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rpd3 36 35
  • 79 (a)
HDAC3 36
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea hda-1 36 34 35
  • 62.86 (n)
hda-3 35
  • 60 (a)
ManyToMany
hda-2 36
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPD3 35
  • 60 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons HDA6 34
  • 61.5 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11399 34
rice
(Oryza sativa)
Liliopsida Os08g0344100 34
  • 58.87 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10476 35
  • 82 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3554 34
Species where no ortholog for HDAC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDAC2 Gene

ENSEMBL:
Gene Tree for HDAC2 (if available)
TreeFam:
Gene Tree for HDAC2 (if available)

Paralogs for HDAC2 Gene

Paralogs for HDAC2 Gene

Pseudogenes.org Pseudogenes for HDAC2 Gene

genes like me logo Genes that share paralogs with HDAC2: view

Variants for HDAC2 Gene

Sequence variations from dbSNP and Humsavar for HDAC2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000022111 -- 113,958,305(+) TACAT(A/G)CCAAG intron-variant
rs1000053525 -- 113,946,405(+) ACAAC(-/T)TATAT intron-variant
rs1000074788 -- 113,947,052(+) TTCTT(C/T)AATAG intron-variant
rs1000120100 -- 113,941,583(+) CAGAG(A/C)ACCTC intron-variant
rs1000191206 -- 113,936,445(+) TTTTC(C/T)TGAGA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HDAC2 Gene

Variant ID Type Subtype PubMed ID
esv2732596 CNV deletion 23290073
nsv474109 CNV novel sequence insertion 20440878
nsv520419 CNV loss 19592680

Variation tolerance for HDAC2 Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HDAC2 Gene

Human Gene Mutation Database (HGMD)
HDAC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HDAC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDAC2 Gene

Disorders for HDAC2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HDAC2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cerebellar ataxia, deafness, and narcolepsy, autosomal dominant
  • autosomal dominant cerebellar ataxia, deafness and narcolepsy
rett syndrome
  • rett syndrome, preserved speech variant
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
- elite association - COSMIC cancer census association via MalaCards
Search HDAC2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HDAC2

Genetic Association Database (GAD)
HDAC2
Human Genome Epidemiology (HuGE) Navigator
HDAC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HDAC2
genes like me logo Genes that share disorders with HDAC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HDAC2 Gene

Publications for HDAC2 Gene

  1. The transcriptional repressor Sp3 is associated with CK2- phosphorylated histone deacetylase 2. (PMID: 12176973) Sun J.M. … Davie J.R. (J. Biol. Chem. 2002) 3 4 22 64
  2. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. (PMID: 10888872) Rountree M.R. … Baylin S.B. (Nat. Genet. 2000) 3 4 22 64
  3. Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. (PMID: 10545197) Schmidt D.R. … Schreiber S.L. (Biochemistry 1999) 3 4 22 64
  4. Human histone deacetylase 2, HDAC2 (Human RPD3), is localized to 6q21 by radiation hybrid mapping. (PMID: 9782097) Betz R. … EkstrAPm T.J. (Genomics 1998) 2 3 22 64
  5. The subcellular distribution and function of MTA1 in cancer differentiation. (PMID: 24970816) Liu J. … Qian H. (Oncotarget 2014) 3 4 64

Products for HDAC2 Gene

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