HDAC2 Gene
protein-coding GIFtS: 72
GCID: GC06M114254
|
|
histone deacetylase 2
| |
Aliases
for HDAC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Histone Deacetylase 21 2 | | EC 3.5.1.983 8 | | RPD31 2 | | Transcriptional Regulator Homolog RPD32 | | YAF11 2 | | YY1-Associated Factor 12 | | HD22 3 | | |
Export aliases for HDAC2 gene to outside databasesPrevious GC identifers: GC06M114097 GC06M114284 GC06M114307 GC06M114368 GC06M111834 |
Summaries
for HDAC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HDAC2:
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of largemultiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of corehistones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with manydifferent proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role intranscriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multipletranscript variants. (provided by RefSeq, Apr 2010)
UniProtKB/Swiss-Prot: HDAC2_HUMAN, Q92769Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B,H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptionalregulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of largemultiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR.Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed ofDNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of aRCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicatedin multilineage blood cell development
 summary
for HDAC2: Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal
of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional
repression. In general, they do not act autonomously but as components of large multiprotein complexes, such
as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of
HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously
expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by
protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the
class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the
nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to
substantial interest in HDAC inhibitors as possible antineoplastic agents.
Gene Wiki entry for HDAC2 (Histone deacetylase 2)
|
Genomic Views
for HDAC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HDAC2 gene promoter:
TBP AP-1 ATF-2 TFIID c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for HDAC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDAC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21HDAC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M114254: view genomic region
(about GC identifiers)
Start:
|
114,254,192 bp from pter |
End:
|
114,332,472 bp from pter |
Size:
|
78,281 bases |
Orientation:
|
minus strand |
|
Proteins
for HDAC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HDAC2_HUMAN, Q92769 (See
protein sequence)Recommended Name: Histone deacetylase 2 Size: 488 amino acids; 55364 Da
Subunit: Component of a RCOR/GFI/KDM1A/HDAC complex. Interacts directly with GFI1 and GFI1B. Interacts with SNW1,HDAC7, PRDM6, SAP30, SETDB1 and SUV39H1. Interacts with the H2AFY (via the non-histone region) (By similarity). Partof the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associateswith MTA2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, orwith SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that containsHDAC1, HDAC2, HMG20B, KDM1A, RCOR1 and PHF21A. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.Part of a complex containing the core histones H2A, H2B, H3 and H4, DEK and unphosphorylated DAXX. Part of a complexcontaining ATR and CHD4. Forms a heterologous complex at least with YY1. Interacts with ATR, CBFA2T3, DNMT1, MINT,HDAC10, HCFC1, NRIP1, KDM4A and PELP1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3,ARID4B, HDAC1 and HDAC2. Interacts with CHFR and SAP30L. Interacts (CK2 phosphorylated form) with SP3. Interacts withTSHZ3 (via its N-terminus). Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1.Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2
Subcellular location: Nucleus
Sequence caution: Sequence=AAH31055.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BAG59420.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAI14206.1;Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction;
1 PDB 3D structure from  and Proteopedia  for HDAC2:3MAX (3D)
Secondary accessions: B4DL58 E1P561 Q5SRI8 Q5SZ86 Q8NEH4Explore the universe of human proteins at neXtProt for HDAC2: NX_Q92769
Post-translational modifications:
S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys-262 and Cys-274 does not affect the enzyme activity butabolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated withneuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching (Bysimilarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92769
4/28 DME Specific Peptides for HDAC2 (Q92769) (see all 28)
HDAC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001518.3
ENSEMBL proteins: ENSP00000430432 ENSP00000430008 ENSP00000357621 ENSP00000417026 ENSP00000427861 ENSP00000429901 ENSP00000428599 ENSP00000428024 ENSP00000428653 ENSP00000429236 ENSP00000428861 ENSP00000428989 ENSP00000381331 Reactome Protein details: Q92769
Human Recombinant Protein Products:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
HDAC2 for ontologies About GeneDecksing
HDAC2 Antibody Products:
Assay Products for HDAC2: |
Protein
Domains /
Families
for HDAC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HDAC2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92769ProtoNet protein and cluster: Q92769 2 Blocks protein families: IPB000286 Histone deacetylase superfamily signature IPB003084 Histone deacetylase signature
UniProtKB/Swiss-Prot: HDAC2_HUMAN, Q92769Similarity: Belongs to the histone deacetylase family. HD type 1 subfamily |
Function
for HDAC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HDAC2_HUMAN, Q92769Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B,H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptionalregulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of largemultiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR.Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed ofDNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of aRCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicatedin multilineage blood cell developmentCatalytic activity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone Genatlas biochemistry entry for HDAC2:histone deacetyltransferase 2,ubiquitously expressed,binding to YY1 for negative regulation of transcription,modulatorof chromatin structure
Enzyme Number (IUBMB): EC 3.5.1.981 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDAC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDAC2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HDAC2 (NM_001527) | |  | Sino Biological Human cDNA Clone for HDAC2 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HDAC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDAC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDAC2 |
Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14): About this table
HDAC2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for HDAC2: Hdac2tm1.2Eno Hdac2tm1.2Pmt Hdac2tm1.2Rdp
15/17 MGI mutant phenotypes (inferred from 9 alleles ) (MGI details for Hdac2) (see all 17):
HDAC2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HDAC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/44 super-pathways (see all 44) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant | | | 2 | Notch Signaling Pathway | | | 3 | Transcription_Sin3 and NuRD in transcription regulation | | | 4 | Immune response_Function of MEF2 in T lymphocytes | | | 5 | Development_Notch Signaling Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 EMD Millipore Pathways for HDAC2 (see all 7)
5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HDAC2 (see all 17)
1 
Cell Signaling Technology (CST) Pathway for HDAC2
5/6  GeneGo (Thomson Reuters) Pathways for HDAC2 (see all 6)
5/12  BioSystems Pathways for HDAC2 (see all 12)
5/18 
Reactome Pathways for HDAC2 (see all 18)
5 
Kegg Pathways (Kegg details for HDAC2):
HDAC2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HDAC2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/1131 Interacting proteins for HDAC2 (Q927691, 2, 3 ENSP000003813314) via UniProtKB, MINT, STRING, and/or I2D (see all 1131)About this table
Gene Ontology (GO): 5/33 biological process terms (GO ID links to tree view) (see all 33): About this table
HDAC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for HDAC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HDAC2 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for HDAC2 |
Compounds for HDAC2 available from Tocris Bioscience About this table
1 HMDB Compound for HDAC2 About this table
2 DrugBank Compounds for HDAC2 About this table
10/25 Novoseek chemical compound relationships for HDAC2 gene (see all 25) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| suberoylanilide hydroxamic acid |
71.4 |
2 |
19738609 (1), 18834886 (1) |
| valproic acid |
57.3 |
8 |
15477762 (2), 19318486 (2), 16294345 (1), 16583461 (1) (see all 5) |
| butyrate |
52.9 |
1 |
16849648 (1) |
| depsipeptide |
48.8 |
1 |
12208741 (1) |
| theophylline |
48.6 |
3 |
19482216 (1), 19812111 (1), 20008877 (1) |
| 5-aza-2'deoxycytidine |
35.8 |
2 |
12646234 (1), 19557157 (1) |
| lysine |
31 |
8 |
20388487 (1), 19822520 (1), 19729656 (1), 19057998 (1) |
| estrogen |
20.8 |
3 |
16309230 (1), 19995069 (1), 17312152 (1) |
| steroid |
18.5 |
10 |
18927347 (2), 20388487 (2), 12727880 (1), 18421014 (1) (see all 7) |
| quinpirole |
16.8 |
1 |
10455328 (1) |
Search CenterWatch for drugs/clinical trials and news about HDAC2
|
Transcripts
for HDAC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HDAC2 gene: NM_001527.3 Unigene Cluster for HDAC2: Histone deacetylase 2 Hs.3352 [show with all ESTs]Unigene Representative Sequence: NR_03344118 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000519065 ENST00000523334 ENST00000519108 ENST00000368632 ENST00000520746
ENST00000518756 ENST00000425835 ENST00000523628 ENST00000521610 ENST00000522371
ENST00000521163 ENST00000518690 ENST00000523240 ENST00000521233 ENST00000520895
ENST00000524334 ENST00000520170 ENST00000398283(uc003pwc.2 uc003pwe.2 uc003pwd.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDAC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDAC2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HDAC2 (NM_001527) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HDAC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDAC2 |
Additional cDNA sequence: AK092156.1 AK097376.1 AK296856.1 BC013141.1 BC031055.1 NR_033441.1 NR_073443.1 U31814.1 18 DOTS entries: DT.40128904 DT.115844 DT.100028821 DT.100028822 DT.121381583 DT.100824032 DT.101985674 DT.40275841 DT.91770961 DT.100824031 DT.92044074 DT.99986284 DT.100716932 DT.100799477 DT.121381524 DT.121381586 DT.121381628 DT.91770959 24/267 AceView cDNA sequences (see all 267): AA372626 BC031055 BC013141 AV704505 BM697242 BU735923 AA125794 CR610322 Z40901 BU689125 AK092156 AA236462 CB159106 BG108040 AA704179 CA441013 CA389293 BM697462 BG259165 BQ675815 D12013 BQ005969 AA125908 CA431410
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for HDAC2 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HDAC2
|
Expression
for HDAC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HDAC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTATGTGA
About this image
See HDAC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HDAC2
SOURCE GeneReport for Unigene cluster: Hs.3352
UniProtKB/Swiss-Prot: HDAC2_HUMAN, Q92769Tissue specificity: Widely expressed; lower levels in brain and lung
SABiosciences Expression via Pathway-Focused PCR Arrays including HDAC2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HDAC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HDAC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDAC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDAC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDAC2 |
Orthologs
for HDAC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HDAC2 gene from 7/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HDAC21 |
histone deacetylase 2 |
85.66(n)
98.16(a) |
|
395635 NM_204831.1 NP_990162.1 |
lizard
(Anolis carolinensis) |
Reptilia |
HDAC26 |
-- |
98(a) |
1 ↔ 1 |
1(187660274-187687702) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.250232 |
Xenopus laevis cDNA clone IMAGE6878180, partial cds |
82.62(n) |
|
BC054208.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rpd33 |
chromatin silencing transcription
co-repressor |
79(a)
(best of 2) |
|
3 64B13 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
hda-13
hda-31 |
Yeast RPD3 protein like3
Protein HDA-31 |
64(a)
(best of 2)3
61.27(n)1
62.7(a)1 |
|
V(14528006-14529575)3
1730741 NM_060625.31 NP_493026.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
HDA61 |
histone deacetylase 6 |
58.78(n)
59.82(a) |
|
836431 NM_125705.3 NP_201116.1 |
rice
(Oryza sativa) |
Liliopsida |
Os08g03441001 |
hypothetical protein |
59.1(n)
60.85(a) |
|
4345332 NM_001068131.1 NP_001061596.1 |
ENSEMBL Gene Tree for HDAC2 (if available)
TreeFam Gene Tree for HDAC2 (if available) |
Paralogs
for HDAC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HDAC2 gene
- HDAC12 HDAC32 HDAC82
5 SIMAP similar genes for HDAC2 using alignment to 13 protein entries: HDAC2_HUMAN (see all proteins):HDAC1 DKFZp686H12203 HDAC3 HDAC8 HDAC9
HDAC2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for HDAC2
PGOHUM00000242903
|
Genomic Variants
for HDAC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HDAC2 (114254192 - 114332472 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for HDAC2
3 CNVs: 93967 93966 51789 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HDAC2 |
|
Disorders
/ Diseases
for HDAC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HDAC2 for disorders About GeneDecksing
OMIM gene information: 605164
OMIM disorders: --
20/54  diseases for HDAC2 (see all 54): About MalaCardsdna topoisomerase ii endometrial stromal sarcoma chronic obstructive pulmonary disease amyotrophic lateral sclerosis
b-cell lymphomas glucocorticoid resistance lateral sclerosis cystic fibrosis
myeloid leukemia sporadic breast cancer pulmonary disease chronic myeloid leukemia
acute myeloid leukemia epithelial ovarian cancer burkitt's lymphoma cutaneous t cell lymphoma
hodgkin's lymphoma pituitary tumor multiple myeloma hepatocellular carcinoma
3 diseases from the University of Copenhagen DISEASES database for HDAC2:Chronic obstructive pulmonary disease Asthma Cancer 10/22 Novoseek disease relationships for HDAC2 gene (see all 22) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pulmonary disease chronic obstructive |
60.8 |
13 |
16452600 (1), 18927347 (1), 19410558 (1), 20008877 (1) (see all 12) |
| colon cancer |
40.4 |
12 |
15477762 (2), 18314102 (2), 15144953 (2), 15981215 (1) (see all 8) |
| asthma |
39.2 |
23 |
19812111 (3), 16604091 (2), 15738302 (2), 17720468 (1) (see all 12) |
| cancer |
32.2 |
19 |
19471575 (4), 18264134 (2), 16642021 (2), 16638127 (1) (see all 11) |
| inflammation |
32.1 |
23 |
19880520 (3), 17147010 (2), 15738302 (2), 15013452 (1) (see all 16) |
| tumors |
29.1 |
30 |
15865607 (3), 18951835 (3), 19318486 (2), 18834886 (2) (see all 17) |
| retinoblastoma |
26.2 |
1 |
15240517 (1) |
| lung diseases |
23.4 |
2 |
19812111 (1) |
| adenoma |
21.5 |
6 |
19057998 (4), 17043312 (1), 15144953 (1) |
| breast cancer |
16.7 |
5 |
12176973 (1), 19372552 (1), 17827154 (1), 18059533 (1) |
Human Genome Epidemiology (HuGE) Navigator: HDAC2 (10 documents)
Export disorders for HDAC2 gene to outside databases
|
Publications
for HDAC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HDAC2 gene, integrated from 9 sources (see all 553):
(articles sorted by number of sources associating them with HDAC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The transcriptional repressor Sp3 is associated with CK2- phosphorylated histone deacetylase 2. (PubMed id 12176973)1, 2, 9 Sun J.M.... Davie J.R. (2002)
- Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. (PubMed id 10545197)1, 2, 9 Schmidt D.R. and Schreiber S.L. (1999)
- DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. (PubMed id 10888872)1, 2, 9 Rountree M.R.... Baylin S.B. (2000)
- Human histone deacetylase 2, HDAC2 (Human RPD3), is localized to 6q21 by radiation hybrid mapping. (PubMed id 9782097)1, 3, 9 Betz R....Ekstrom T.J. (1998)
- Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. (PubMed id 11331609)1, 2, 9 Shi Y....Evans R.M. (2001)
- Maintenance of silent chromatin through replication r equires SWI/SNF-like chromatin remodeler SMARCAD1. (PubMed id 21549307)1, 2 Rowbotham S.P....Mermoud J.E. (2011)
- Chfr is linked to tumour metastasis through the downregulation of HDAC1. (PubMed id 19182791)1, 2 Oh Y.M.... Seol J.H. (2009)
- SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. (PubMed id 16820529)1, 2 Viiri K.M.... Lohi O. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. (PubMed id 15927959)1, 2 Gray S.G.... Dangond F. (2005)
|
External Searches for HDAC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HDAC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HDAC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HDAC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HDAC2 gene:
Search GeneIP for patents involving HDAC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HDAC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for HDAC2 | | OriGene shRNA RFP for HDAC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDAC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HDAC2 | | | OriGene Protein Over-expression Lysate for HDAC2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HDAC2 | | OriGene 3'-UTR Clone for HDAC2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDAC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDAC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HDAC2 | | OriGene Custom Protein Services for HDAC2 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HDAC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HDAC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDAC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDAC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDAC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDAC2 |
| |
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| | Antibodies & Assays for HDAC2 |
| | | | Tocris compounds for HDAC2 |
| |  |  |  |  | | | | | | Recombinant Protein for HDAC2 |
|
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 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDAC2 |
|  |  |  | | | | ThermoFisher Antibody for HDAC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDAC2 |
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