Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HDAC11 Gene

Aliases for HDAC11 Gene

  • Histone Deacetylase 11 2 3
  • EC 3.5.1.98 4 63
  • HD11 3 4

External Ids for HDAC11 Gene

Previous GeneCards Identifiers for HDAC11 Gene

  • GC03P013451

Summaries for HDAC11 Gene

Entrez Gene Summary for HDAC11 Gene

  • This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]

GeneCards Summary for HDAC11 Gene

HDAC11 (Histone Deacetylase 11) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include transcription factor binding and NAD-dependent histone deacetylase activity (H3-K9 specific).

UniProtKB/Swiss-Prot for HDAC11 Gene

  • Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Tocris Summary for HDAC11 Gene

  • Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.

Gene Wiki entry for HDAC11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDAC11 Gene

Genomics for HDAC11 Gene

Regulatory Elements for HDAC11 Gene

Genomic Location for HDAC11 Gene

Start:
13,479,724 bp from pter
End:
13,506,424 bp from pter
Size:
26,701 bases
Orientation:
Plus strand

Genomic View for HDAC11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HDAC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDAC11 Gene

Proteins for HDAC11 Gene

  • Protein details for HDAC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DB2-HDA11_HUMAN
    Recommended name:
    Histone deacetylase 11
    Protein Accession:
    Q96DB2
    Secondary Accessions:
    • B4DDK1
    • Q9H6I7
    • Q9H6X3
    • Q9NTC9

    Protein attributes for HDAC11 Gene

    Size:
    347 amino acids
    Molecular mass:
    39183 Da
    Quaternary structure:
    • Interacts with HDAC6.
    Miscellaneous:
    • Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor
    SequenceCaution:
    • Sequence=BAB15127.1; Type=Erroneous termination; Positions=107; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=CAB70712.1; Type=Frameshift; Positions=177, 198, 200; Evidence={ECO:0000305};

    Alternative splice isoforms for HDAC11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDAC11 Gene

Proteomics data for HDAC11 Gene at MOPED

Selected DME Specific Peptides for HDAC11 Gene

Post-translational modifications for HDAC11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for HDAC11 Gene

Protein Domains for HDAC11 Gene

Suggested Antigen Peptide Sequences for HDAC11 Gene

Graphical View of Domain Structure for InterPro Entry

Q96DB2

UniProtKB/Swiss-Prot:

HDA11_HUMAN :
  • Q96DB2
Family:
  • Belongs to the histone deacetylase family.
genes like me logo Genes that share domains with HDAC11: view

No data available for Gene Families for HDAC11 Gene

Function for HDAC11 Gene

Molecular function for HDAC11 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
UniProtKB/Swiss-Prot Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Enzyme Numbers (IUBMB) for HDAC11 Gene

Gene Ontology (GO) - Molecular Function for HDAC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004407 histone deacetylase activity IDA 11948178
GO:0005515 protein binding --
GO:0008134 transcription factor binding TAS 12711221
GO:0016787 hydrolase activity --
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA --
genes like me logo Genes that share ontologies with HDAC11: view

Phenotypes for HDAC11 Gene

GenomeRNAi human phenotypes for HDAC11:
genes like me logo Genes that share phenotypes with HDAC11: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HDAC11 Gene

Localization for HDAC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDAC11 Gene

Nucleus. Note=Predominantly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HDAC11 Gene COMPARTMENTS Subcellular localization image for HDAC11 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HDAC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IDA 11948178
GO:0005634 nucleus IDA 11948178
GO:0005886 plasma membrane IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HDAC11: view

Pathways for HDAC11 Gene

genes like me logo Genes that share pathways with HDAC11: view

Gene Ontology (GO) - Biological Process for HDAC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008152 metabolic process --
GO:0014003 oligodendrocyte development IEA --
GO:0016568 chromatin modification TAS 12711221
genes like me logo Genes that share ontologies with HDAC11: view

Compounds for HDAC11 Gene

(29) ApexBio Compounds for HDAC11 Gene

Compound Action Cas Number
AR-42 (OSU-HDAC42) Pan-HDAC inhibitor [935881-37-1]
Belinostat (PXD101) Novel and potent hydroxamate-type HDAC inhibitor [414864-00-9]
CI994 (Tacedinaline) HDAC1 and 3 inhibitor [112522-64-2]
CUDC-101 Multitargeted HDAC inhibitor [1012054-59-9]
CUDC-907 dual PI3K and HDAC inhibitor [1339928-25-4]
Droxinostat Selective HDAC inhibitor [99873-43-5]
Entinostat (MS-275,SNDX-275) Entinostat inhibits HDAC1 and HDAC3 but not HDAC8 [209783-80-2]
ITF2357 (Givinostat) HDAC inhibitor, inhibits class I and class II HDACs [732302-99-7]
JNJ-26481585 Potent pan-HDAC inhibitor [875320-29-9]
LAQ824 (NVP-LAQ824,Dacinostat) Novel and potent HDAC inhibitor [404951-53-7]
M344 Cell-permeable HDAC inhibitor [251456-60-7]
MC1568 Selective class IIa HDAC inhibitor [852475-26-4]
Mocetinostat (MGCD0103, MG0103) Class I selective HDAC inhibitor [726169-73-9]
Panobinostat (LBH589) Broad spectrum HDAC inhibitor, inhibits HDAC1-11 [404950-80-7]
PCI-24781 (CRA-024781) Novel pan-HDAC inhibitor [783355-60-2]
PCI-34051 Potent, specific HDAC8 inhibitor [950762-95-5]
Pracinostat (SB939) Pan-HDAC inhibitor, inhibits all HDAC isozymes except HDAC6 and HDAC7 [929016-96-6]
Resminostat (RAS2410) Potent inhibitor of HDAC classes I and II [864814-88-0]
RG2833 Brain-penetrant HDAC inhibitor [1215493-56-3]
RGFP966 Specific HDAC3 inhibitor [1396841-57-8]
Rocilinostat (ACY-1215) Selective HDAC6 inhibitor [1316214-52-4]
Romidepsin (FK228, depsipeptide) Potent HDAC1 and HDAC2 inhibitor [128517-07-7]
Scriptaid Cell-permeable HDAC inhibitor [287383-59-9]
Trichostatin A (TSA) Cell-permeable, non-competitive, and reversible HDAC inhibitor [58880-19-6]
Tubacin Selective HDAC6 inhibitor [1350555-93-9]
Tubastatin A Potent and selective HDAC6 inhibitor [1252003-15-8]
Tubastatin A HCl Potent and selective HDAC6 inhibitor [1310693-92-5]
Valproic acid sodium salt HDAC inhibitor [1069-66-5]
Vorinostat (SAHA, MK0683) Class I and II HDAC inhibitor [149647-78-9]

(5) Tocris Compounds for HDAC11 Gene

Compound Action Cas Number
FK 228 Potent and selective class I histone deacetylase inhibitor; antitumor [128517-07-7]
LMK 235 Selective HDAC4/HDAC5 inhibitor [1418033-25-6]
PCI 34051 Potent and selective histone deacetylase 8 (HDAC8) inhibitor; induces apoptosis in T cell-derived cell lines [950762-95-5]
SAHA Class I and II HDAC inhibitor [149647-78-9]
Trichostatin A Potent histone deacetylase inhibitor [58880-19-6]
genes like me logo Genes that share compounds with HDAC11: view

Transcripts for HDAC11 Gene

Unigene Clusters for HDAC11 Gene

Histone deacetylase 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HDAC11 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - - - - - - - - -
SP5: - - -
SP6: -
SP7: - - - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - - - - - - - - -
SP10: -
SP11: - - - - - - - - - -
SP12: - - - - - - -
SP13:

Relevant External Links for HDAC11 Gene

GeneLoc Exon Structure for
HDAC11
ECgene alternative splicing isoforms for
HDAC11

Expression for HDAC11 Gene

mRNA expression in normal human tissues for HDAC11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HDAC11 Gene

SOURCE GeneReport for Unigene cluster for HDAC11 Gene Hs.744132

mRNA Expression by UniProt/SwissProt for HDAC11 Gene

Q96DB2-HDA11_HUMAN
Tissue specificity: Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis
genes like me logo Genes that share expressions with HDAC11: view

No data available for mRNA differential expression in normal tissues for HDAC11 Gene

Orthologs for HDAC11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HDAC11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDAC11 35
  • 99.89 (n)
  • 100 (a)
HDAC11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HDAC11 35
  • 87.99 (n)
  • 91.35 (a)
HDAC11 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HDAC11 35
  • 89.34 (n)
  • 94.04 (a)
HDAC11 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hdac11 35
  • 87.42 (n)
  • 92.22 (a)
Hdac11 16
Hdac11 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HDAC11 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HDAC11 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hdac11 35
  • 87.42 (n)
  • 91.64 (a)
chicken
(Gallus gallus)
Aves HDAC11 35
  • 69.25 (n)
  • 79.76 (a)
HDAC11 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HDAC11 36
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hdac11 35
  • 69.09 (n)
  • 74.71 (a)
hdac11 36
  • 77 (a)
OneToMany
HDAC11 (2 of 3) 36
  • 27 (a)
OneToMany
HDAC11 (3 of 3) 36
  • 60 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001736 35
  • 58.91 (n)
  • 56.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta HdacX 35
  • 56.06 (n)
  • 52.41 (a)
HdacX 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hda-11 35
  • 50.92 (n)
  • 49.84 (a)
hda-11 36
  • 46 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOS1 36
  • 14 (a)
OneToMany
HOS2 36
  • 18 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.12177 35
thale cress
(Arabidopsis thaliana)
eudicotyledons HDA2 35
  • 56.59 (n)
  • 58.88 (a)
rice
(Oryza sativa)
Liliopsida Os06g0571100 35
  • 58.98 (n)
  • 57.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for HDAC11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HDAC11 Gene

ENSEMBL:
Gene Tree for HDAC11 (if available)
TreeFam:
Gene Tree for HDAC11 (if available)

Paralogs for HDAC11 Gene

genes like me logo Genes that share paralogs with HDAC11: view

No data available for Paralogs for HDAC11 Gene

Variants for HDAC11 Gene

Sequence variations from dbSNP and Humsavar for HDAC11 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs468513 -- 13,486,998(-) GCCAC(A/G)ATGTT intron-variant
rs693291 -- 13,486,911(+) TTTCA(A/G)AATCC intron-variant
rs1116048 -- 13,495,836(+) TGCCA(C/T)CACCC intron-variant
rs1597474 -- 13,501,171(+) CAACC(C/T)GCGCT intron-variant
rs1812622 -- 13,496,095(+) TGGAT(A/G)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDAC11 Gene

Variant ID Type Subtype PubMed ID
nsv876550 CNV Loss 21882294
nsv876551 CNV Gain 21882294
nsv470416 CNV Loss 18288195
nsv876552 CNV Loss 21882294

Relevant External Links for HDAC11 Gene

HapMap Linkage Disequilibrium report
HDAC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDAC11 Gene

Disorders for HDAC11 Gene

(1) University of Copenhagen DISEASES for HDAC11 Gene

Relevant External Links for HDAC11

Genetic Association Database (GAD)
HDAC11
genes like me logo Genes that share disorders with HDAC11: view

No data available for UniProtKB/Swiss-Prot for HDAC11 Gene

Publications for HDAC11 Gene

  1. Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. (PMID: 11948178) Gao L. … Atadja P. (J. Biol. Chem. 2002) 2 3 4
  2. Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours. (PMID: 17201809) Lindberg D. … Westin G. (Clin. Endocrinol. (Oxf) 2007) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 48

Products for HDAC11 Gene

Sources for HDAC11 Gene

Back to Top

Content