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HDAC11 Gene

protein-coding   GIFtS: 59
GCID: GC03P013496

Histone Deacetylase 11

  Search for HDAC11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Deacetylase 111 2
HD112 3
EC 3.5.1.983 8

External Ids:    HGNC: 190861   Entrez Gene: 798852   Ensembl: ENSG000001635177   OMIM: 6072265   UniProtKB: Q96DB23   

Export aliases for HDAC11 gene to outside databases

Previous GC identifer: GC03P013451


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HDAC11 Gene:
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be
involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript
variants.(provided by RefSeq, Apr 2009)

GeneCards Summary for HDAC11 Gene:
HDAC11 (histone deacetylase 11) is a protein-coding gene. GO annotations related to this gene include NAD-dependent histone deacetylase activity (H3-K9 specific) and transcription factor binding.

UniProtKB/Swiss-Prot: HDA11_HUMAN, Q96DB2
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A,
H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in
transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the
formation of large multiprotein complexes

summary for HDAC11 Gene:
Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal
of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional
repression. In general, they do not act autonomously but as components of large multiprotein complexes, such
as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of
HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously
expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by
protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the
class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the
nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to
substantial interest in HDAC inhibitors as possible antineoplastic agents.

Gene Wiki entry for HDAC11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HDAC11 gene promoter:
         SREBP-1a   SREBP-1c   Lmo2   CUTL1   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHDAC11 promoter sequence
   Search Chromatin IP Primers for HDAC11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HDAC11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25.1

HDAC11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDAC11 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P013496:  view genomic region     (about GC identifiers)

Start:
13,521,224 bp from pter      End:
13,547,924 bp from pter
Size:
26,701 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HDA11_HUMAN, Q96DB2 (See protein sequence)
Recommended Name: Histone deacetylase 11  
Size: 347 amino acids; 39183 Da
Subunit: Interacts with HDAC6
Miscellaneous: Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor
Sequence caution: Sequence=BAB15127.1; Type=Erroneous termination; Positions=107; Note=Translated as Gln;
Sequence=CAB70712.1; Type=Frameshift; Positions=177, 198, 200;
Secondary accessions: B4DDK1 Q9H6I7 Q9H6X3 Q9NTC9
Alternative splicing: 2 isoforms:  Q96DB2-1   Q96DB2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HDAC11: NX_Q96DB2

Explore proteomics data for HDAC11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for HDAC11 (Q96DB2)
     EKLHPFD  RGGGFCA  IIDLDAHQGNGHE 


    See HDAC11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129513.1  NP_079103.2  

    ENSEMBL proteins: 
     ENSP00000412514   ENSP00000295757   ENSP00000384706   ENSP00000384123   ENSP00000399792  
     ENSP00000385528   ENSP00000385475   ENSP00000405403   ENSP00000385252   ENSP00000384019  
     ENSP00000429794   ENSP00000411792   ENSP00000398651   ENSP00000402298   ENSP00000396122  
     ENSP00000395188   ENSP00000401487  
    Reactome Protein details: Q96DB2

    HDAC11 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for HDAC11

     
    Search eBioscience for Proteins for HDAC11 

    HDAC11 Antibody Products:

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    HDAC11 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HDAC11
    Cloud-Clone Corp. CLIAs for HDAC11
    Search eBioscience for ELISAs for HDAC11 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000286 His_deacetylse
     IPR023801 His_deacetylse_dom

    Graphical View of Domain Structure for InterPro Entry Q96DB2

    ProtoNet protein and cluster: Q96DB2

    1 Blocks protein domain: IPB000286 Histone deacetylase superfamily signature

    UniProtKB/Swiss-Prot: HDA11_HUMAN, Q96DB2
    Similarity: Belongs to the histone deacetylase family


    Find genes that share domains with HDAC11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HDA11_HUMAN, Q96DB2
    Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A,
    H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in
    transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the
    formation of large multiprotein complexes
    Catalytic activity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone

         Enzyme Number (IUBMB): EC 3.5.1.981 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004407histone deacetylase activity IDA11948178
    GO:0005515protein binding ----
    GO:0008134transcription factor binding TAS12711221
    GO:0016787hydrolase activity ----
    GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific) IEA--
         
    Find genes that share ontologies with HDAC11           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for HDAC11:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HDAC11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HDAC11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HDAC11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HDAC11

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    1 qRT-PCR Assays for microRNA that regulate HDAC11:
    hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidHDAC11 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HDAC11
    Predesigned siRNA for gene silencing in human, mouse, rat HDAC11

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): HDAC11 (NM_001136041)
    Sino Biological Human cDNA Clone for HDAC11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HDAC11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDAC11

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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HDA11_HUMAN, Q96DB2: Nucleus. Note=Predominantly nuclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane4
    cytosol2
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex IDA11948178
    GO:0005634nucleus IDA11948178
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with HDAC11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HDAC11 About   (see all 24)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1p53 Signaling
    p53 Signaling0.38
    p53 Pathway0.38
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    3Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1-S Phase Transition0.67
    4Macrophage Differentiation and Growth Inhibition by METS
    Macrophage Differentiation and Growth Inhibition by METS0.30
    DNA Methylation and Transcriptional Repression0.30
    5Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with HDAC11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HDAC11 (see all 15)
        DNA Methylation and Transcriptional Repression
    Protein Acetylation and Deacetylation
    BRCA1 Pathway
    Glucocorticoid Receptor Signaling
    Intracellular Calcium Signaling

    3 BioSystems Pathways for HDAC11
        Neural Crest Differentiation
    Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class II

    2 Sino Biological Pathways for HDAC11
        Notch Signaling Pathway
    p53 Pathway

    3 Reactome Pathways for HDAC11
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    Constitutive Signaling by NOTCH1 PEST Domain Mutants

    1 PharmGKB Pathway for HDAC11
        Valproic Acid Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for HDAC11):
        Alcoholism
    Viral carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HDAC11: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HDAC11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HDAC11 (Q96DB22, 3 ENSP000002957574) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NELFCDQ8IXH72, 3MINT-64861 I2D: score=5 
    MAPK6Q166592, 3MINT-8261230 I2D: score=2 
    HDAC6Q9UBN73, ENSP000003340614I2D: score=3 STRING: ENSP00000334061
    GSCP569153, ENSP000002385584I2D: score=1 STRING: ENSP00000238558
    CDT1Q9H2113, ENSP000003010194I2D: score=1 STRING: ENSP00000301019
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0014003oligodendrocyte development IEA--
    GO:0016568chromatin modification TAS12711221
    GO:0016575histone deacetylation IDA11948178

    Find genes that share ontologies with HDAC11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for HDAC11 (see all 29)     About this table
    CompoundAction CAS #
    AR-42 (OSU-HDAC42)Pan-HDAC inhibitor[935881-37-1]
    Belinostat (PXD101)Novel and potent hydroxamate-type HDAC inhibitor[414864-00-9]
    CI994 (Tacedinaline)HDAC1 and 3 inhibitor[112522-64-2]
    CUDC-101Multitargeted HDAC inhibitor[1012054-59-9]
    CUDC-907PI3K and HDAC inhibitor[1339928-25-4]
    DroxinostatSelective HDAC inhibitor[99873-43-5]
    Entinostat (MS-275,SNDX-275)Entinostat inhibits HDAC1 and HDAC3 but not HDAC8[209783-80-2]
    ITF2357 (Givinostat)HDAC inhibitor, inhibits class I and class II HDACs[732302-99-7]
    JNJ-26481585Potent pan-HDAC inhibitor[875320-29-9]
    LAQ824 (NVP-LAQ824,Dacinostat)Novel and potent HDAC inhibitor[404951-53-7]

    Compounds for HDAC11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TCS HDAC6 20bSelective HDAC6 inhibitor[956154-63-5]
    LMK 235Selective HDAC4/HDAC5 inhibitor[1418033-25-6]
    Trichostatin AHistone deacetylase inhibitor[58880-19-6]
    TubacinHDAC6 inhibitor; inhibits alpha-tubulin deacetylation[1350555-93-9]
    Sodium 4-PhenylbutyrateHistone deacetylase inhibitor[1716-12-7]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HDAC11 gene (2 alternative transcripts): 
    NM_001136041.2  NM_024827.3  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000433119 ENST00000295757(uc010heb.3 uc003bxy.3 uc011aux.2 uc011auy.2)
    ENST00000402259 ENST00000402271 ENST00000425430 ENST00000404548 ENST00000404040
    ENST00000458642 ENST00000405478 ENST00000405025 ENST00000475818 ENST00000522202
    ENST00000418189 ENST00000434848 ENST00000416248 ENST00000455904 ENST00000437379
    ENST00000487585
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate HDAC11:
    hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidHDAC11 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HDAC11
      QuantiTect SYBR Green Assays in human, mouse, rat HDAC11
      QuantiFast Probe-based Assays in human, mouse, rat HDAC11

    Selected AceView cDNA sequences (see all 135):

    AL551256 BQ928115 BP375242 BF365978 AI360857 BM671310 AI889025 AI359398 
    BM710130 BC009676 AK025890 BF739861 CB152774 BF194759 CD515668 AK025426 
    BE856419 CR612266 BP374691 BI520504 AI204273 CR603019 AL134619 BF195399 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HDAC11 (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d
    SP1:                                                        -                                   -           -           -                                 
    SP2:                          -     -     -                 -                                   -           -                                             
    SP3:                                      -                 -                                   -           -                                             
    SP4:                          -     -     -                 -     -     -     -     -     -     -           -           -                                 
    SP5:                                      -                 -                                   -                                                         


    ECgene alternative splicing isoforms for HDAC11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HDAC11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATTTGCTG
    HDAC11 Expression
    About this image


    HDAC11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
    HDAC11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HDAC11 Protein Expression

    UniProtKB/Swiss-Prot: HDA11_HUMAN, Q96DB2
    Tissue specificity: Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney
    and testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HDAC11: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat HDAC11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDAC11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HDAC11 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hdac111 , 5 histone deacetylase 111, 5 87.42(n)1
    92.22(a)1
      6 (40.38 cM)5
    2322321  NM_144919.21  NP_659168.11 
     911566655 
    chicken
    (Gallus gallus)
    Aves HDAC111 histone deacetylase 11 69.25(n)
    79.76(a)
      415978  NM_001277141.1  NP_001264070.1 
    lizard
    (Anolis carolinensis)
    Reptilia HDAC116
    histone deacetylase 11
    75(a)
    1 ↔ 1
    2(189308830-189326936)
    zebrafish
    (Danio rerio)
    Actinopterygii hdac111 histone deacetylase 11 69.09(n)
    74.71(a)
      431718  NM_001002171.1  NP_001002171.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta HdacX1 Histone deacetylase X 56.06(n)
    52.41(a)
      326120  NM_001260367.1  NP_001247296.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hda-111 hda-11 50.92(n)
    49.84(a)
      183226  NM_073298.3  NP_505699.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HOS26
    HOS16
    Histone deacetylase required for gene activation v...
    Class I histone deacetylase (HDAC) family member t...
    18(a)
    14(a)
    many → 1
    many → 1
    VII(140368-141726) YGL194C
    XVI(682941-684353) YPR068C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HDA21 HDA2 56.59(n)
    58.88(a)
      832673  NM_122505.3  NP_568480.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g05711001 Os06g0571100 58.98(n)
    57.94(a)
      4341352  NM_001064449.1  NP_001057914.1 


    ENSEMBL Gene Tree for HDAC11 (if available)
    TreeFam Gene Tree for HDAC11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HDAC11 gene
    1 SIMAP similar gene for HDAC11 using alignment to 16 protein entries:     HDA11_HUMAN (see all proteins):
    DKFZp434L0312

    Find genes that share paralogs with HDAC11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for HDAC11 (see all 593)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115165021,2
    C,F--13519838(+) AGGATA/C/TGCTTG 1 -- us2k12CSA 4
    rs1882213981,2
    --13519846(+) TTGAGC/GCCAGG 2 -- us2k10--------
    rs26552171,2
    C,F,A,H--13519938(+) CTTATC/TCAGAC 2 -- us2k133Minor allele frequency- T:0.24NS EA NA WA CSA 3200
    rs1381326371,2
    --13519969(+) TCAGCC/TTCAGG 2 -- us2k10--------
    rs747223011,2
    --13519974(+) TTCAGA/GTCCAG 2 -- us2k10--------
    rs1438816071,2
    --13520270(+) AAAAGC/TATTTG 2 -- us2k10--------
    rs748949441,2
    F--13520273(+) AGCATT/CTGGAC 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1482030071,2
    --13520306(+) GGTCTC/GTGAAT 2 -- us2k10--------
    rs1918631571,2
    --13520314(+) AATAAC/TAATCA 2 -- us2k10--------
    rs783750981,2
    F--13520375(+) AAGTGC/TAACCA 2 -- us2k11Minor allele frequency- T:0.07NA 120

    HapMap Linkage Disequilibrium report for HDAC11 (13521224 - 13547924 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HDAC11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876550CNV Loss21882294
    nsv876552CNV Loss21882294
    nsv470416CNV Loss18288195
    nsv876551CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HDAC11
    DNA2.0 Custom Variant and Variant Library Synthesis for HDAC11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607226    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for HDAC11:
    Hodgkin's lymphoma

    Find genes that share disorders with HDAC11           About GenesLikeMe

    Genetic Association Database (GAD): HDAC11

    Export disorders for HDAC11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HDAC11 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with HDAC11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. (PubMed id 11948178)1, 2, 3 Gao L.... Atadja P. (J. Biol. Chem. 2002)
    2. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours. (PubMed id 17201809)1, 9 Lindberg D....Westin G. (Clin. Endocrinol. (Oxf) 2007)
    6. HDAC11 is a novel drug target in carcinomas. (PubMed id 23024001)1 Deubzer H.E....Witt O. (Int. J. Cancer 2013)
    7. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    8. Increased gene expression of histone deacetylases in patients with Philadelphia-negative chronic myeloproliferative neoplasms. (PubMed id 21806350)1 Skov V....Hasselbalch H.C. (amp 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79885 HGNC: 19086 AceView: HDAC11 Ensembl:ENSG00000163517 euGenes: HUgn79885
    ECgene: HDAC11 Kegg: 79885 H-InvDB: HDAC11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HDAC11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HDAC11 gene:
    Search GeneIP for patents involving HDAC11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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