Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HDAC10 Gene

Aliases for HDAC10 Gene

  • Histone Deacetylase 10 2 3
  • HD10 3 4
  • EC 3.5.1.98 4

External Ids for HDAC10 Gene

Summaries for HDAC10 Gene

Entrez Gene Summary for HDAC10 Gene

  • The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for HDAC10 Gene

HDAC10 (Histone Deacetylase 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include enzyme binding and histone deacetylase activity. An important paralog of this gene is HDAC4.

UniProtKB/Swiss-Prot for HDAC10 Gene

  • Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes

Tocris Summary for HDAC10 Gene

  • Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.

Gene Wiki entry for HDAC10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDAC10 Gene

Genomics for HDAC10 Gene

Genomic Location for HDAC10 Gene

Start:
50,245,183 bp from pter
End:
50,251,405 bp from pter
Size:
6,223 bases
Orientation:
Minus strand

Genomic View for HDAC10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HDAC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDAC10 Gene

Regulatory Elements for HDAC10 Gene

Proteins for HDAC10 Gene

  • Protein details for HDAC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969S8-HDA10_HUMAN
    Recommended name:
    Histone deacetylase 10
    Protein Accession:
    Q969S8
    Secondary Accessions:
    • Q08AP4
    • Q6STF9
    • Q96P77
    • Q96P78
    • Q9H028
    • Q9UGX1
    • Q9UGX2

    Protein attributes for HDAC10 Gene

    Size:
    669 amino acids
    Molecular mass:
    71445 Da
    Quaternary structure:
    • Interacts with HDAC2, HDAC3 and NCOR2.

    Alternative splice isoforms for HDAC10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDAC10 Gene

Proteomics data for HDAC10 Gene at MOPED

Post-translational modifications for HDAC10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys80

Other Protein References for HDAC10 Gene

No data available for DME Specific Peptides for HDAC10 Gene

Domains for HDAC10 Gene

Protein Domains for HDAC10 Gene

UniProtKB/Swiss-Prot:

HDA10_HUMAN
Family:
  • Belongs to the histone deacetylase family. HD type 2 subfamily.:
    • Q969S8
genes like me logo Genes that share domains with HDAC10: view

No data available for Gene Families for HDAC10 Gene

Function for HDAC10 Gene

Molecular function for HDAC10 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
UniProtKB/Swiss-Prot Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes

Enzyme Numbers (IUBMB) for HDAC10 Gene

Gene Ontology (GO) - Molecular Function for HDAC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004407 histone deacetylase activity IDA 11739383
GO:0005515 protein binding IPI 17172643
GO:0016787 hydrolase activity --
GO:0019899 enzyme binding IPI 11861901
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA --
genes like me logo Genes that share ontologies with HDAC10: view

Phenotypes for HDAC10 Gene

genes like me logo Genes that share phenotypes with HDAC10: view

miRNA for HDAC10 Gene

miRTarBase miRNAs that target HDAC10

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for HDAC10 Gene

Localization for HDAC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDAC10 Gene

Cytoplasm. Nucleus. Note=Excluded from the nucleoli.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HDAC10 Gene COMPARTMENTS Subcellular localization image for HDAC10 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HDAC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IDA 11861901
GO:0005634 nucleus IDA 11739383
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 11726666
genes like me logo Genes that share ontologies with HDAC10: view

Pathways for HDAC10 Gene

genes like me logo Genes that share pathways with HDAC10: view

Gene Ontology (GO) - Biological Process for HDAC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11726666
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 11861901
GO:0006476 protein deacetylation IDA 17172643
genes like me logo Genes that share ontologies with HDAC10: view

Compounds for HDAC10 Gene

(29) ApexBio Compounds for HDAC10 Gene

Compound Action Cas Number
AR-42 (OSU-HDAC42) Pan-HDAC inhibitor [935881-37-1]
Belinostat (PXD101) Novel and potent hydroxamate-type HDAC inhibitor [414864-00-9]
CI994 (Tacedinaline) HDAC1 and 3 inhibitor [112522-64-2]
CUDC-101 Multitargeted HDAC inhibitor [1012054-59-9]
CUDC-907 dual PI3K and HDAC inhibitor [1339928-25-4]
Droxinostat Selective HDAC inhibitor [99873-43-5]
Entinostat (MS-275,SNDX-275) Entinostat inhibits HDAC1 and HDAC3 but not HDAC8 [209783-80-2]
ITF2357 (Givinostat) HDAC inhibitor, inhibits class I and class II HDACs [732302-99-7]
JNJ-26481585 Potent pan-HDAC inhibitor [875320-29-9]
LAQ824 (NVP-LAQ824,Dacinostat) Novel and potent HDAC inhibitor [404951-53-7]
M344 Cell-permeable HDAC inhibitor [251456-60-7]
MC1568 Selective class IIa HDAC inhibitor [852475-26-4]
Mocetinostat (MGCD0103, MG0103) Class I selective HDAC inhibitor [726169-73-9]
Panobinostat (LBH589) Broad spectrum HDAC inhibitor, inhibits HDAC1-11 [404950-80-7]
PCI-24781 (CRA-024781) Novel pan-HDAC inhibitor [783355-60-2]
PCI-34051 Potent, specific HDAC8 inhibitor [950762-95-5]
Pracinostat (SB939) Pan-HDAC inhibitor, inhibits all HDAC isozymes except HDAC6 and HDAC7 [929016-96-6]
Resminostat (RAS2410) Potent inhibitor of HDAC classes I and II [864814-88-0]
RG2833 Brain-penetrant HDAC inhibitor [1215493-56-3]
RGFP966 Specific HDAC3 inhibitor [1396841-57-8]
Rocilinostat (ACY-1215) Selective HDAC6 inhibitor [1316214-52-4]
Romidepsin (FK228, depsipeptide) Potent HDAC1 and HDAC2 inhibitor [128517-07-7]
Scriptaid Cell-permeable HDAC inhibitor [287383-59-9]
Trichostatin A (TSA) Cell-permeable, non-competitive, and reversible HDAC inhibitor [58880-19-6]
Tubacin Selective HDAC6 inhibitor [1350555-93-9]
Tubastatin A Potent and selective HDAC6 inhibitor [1252003-15-8]
Tubastatin A HCl Potent and selective HDAC6 inhibitor [1310693-92-5]
Valproic acid sodium salt HDAC inhibitor [1069-66-5]
Vorinostat (SAHA, MK0683) Class I and II HDAC inhibitor [149647-78-9]

(5) Tocris Compounds for HDAC10 Gene

Compound Action Cas Number
LMK 235 Selective HDAC4/HDAC5 inhibitor [1418033-25-6]
Sodium 4-Phenylbutyrate Histone deacetylase inhibitor [1716-12-7]
TCS HDAC6 20b Selective HDAC6 inhibitor [956154-63-5]
Trichostatin A Histone deacetylase inhibitor [58880-19-6]
Tubacin HDAC6 inhibitor; inhibits alpha-tubulin deacetylation [1350555-93-9]
genes like me logo Genes that share compounds with HDAC10: view

Transcripts for HDAC10 Gene

Unigene Clusters for HDAC10 Gene

Histone deacetylase 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HDAC10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - - -
SP14: -
SP15: - - - - - -
SP16: - - - - - - - -
SP17: - - -
SP18:
SP19:
SP20: - - -
SP21: - - - - - -
SP22:
SP23: -
SP24:
SP25:
SP26:
SP27:

ExUns: 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6: -
SP7: - - - -
SP8: - -
SP9: - -
SP10:
SP11: -
SP12: - - - -
SP13: - - - - -
SP14: - - - - -
SP15:
SP16:
SP17: - - - - -
SP18: - -
SP19: -
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

Relevant External Links for HDAC10 Gene

GeneLoc Exon Structure for
HDAC10
ECgene alternative splicing isoforms for
HDAC10

Expression for HDAC10 Gene

mRNA expression in normal human tissues for HDAC10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HDAC10 Gene

SOURCE GeneReport for Unigene cluster for HDAC10 Gene Hs.26593

mRNA Expression by UniProt/SwissProt for HDAC10 Gene

Q969S8-HDA10_HUMAN
Tissue specificity: Ubiquitous. High expression in liver, spleen, pancreas and kidney
genes like me logo Genes that share expressions with HDAC10: view

Orthologs for HDAC10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HDAC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDAC10 36
  • 99.35 (n)
  • 99.1 (a)
HDAC10 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HDAC10 36
  • 82.75 (n)
  • 80.33 (a)
HDAC10 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HDAC10 36
  • 82.04 (n)
  • 79.06 (a)
HDAC10 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hdac10 36
  • 78.03 (n)
  • 76.21 (a)
Hdac10 16
Hdac10 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HDAC10 37
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 68 (a)
OneToMany
-- 37
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hdac10 36
  • 76.99 (n)
  • 75.04 (a)
chicken
(Gallus gallus)
Aves HDAC10 36
  • 53.53 (n)
  • 50.77 (a)
HDAC10 37
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HDAC10 37
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdac10 36
  • 52.5 (n)
  • 50.15 (a)
zebrafish
(Danio rerio)
Actinopterygii hdac10 36
  • 54.96 (n)
  • 47.46 (a)
hdac10 37
  • 45 (a)
OneToOne
wufd19e10 36
fruit fly
(Drosophila melanogaster)
Insecta HDAC6 37
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F43G6.17 37
  • 23 (a)
OneToMany
hda-10 37
  • 29 (a)
OneToMany
hda-5 37
  • 27 (a)
OneToMany
hda-6 37
  • 20 (a)
OneToMany
Y51H1A.5 38
  • 41 (a)
F43G6.4 38
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HDA1 37
  • 22 (a)
OneToMany
Species with no ortholog for HDAC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDAC10 Gene

ENSEMBL:
Gene Tree for HDAC10 (if available)
TreeFam:
Gene Tree for HDAC10 (if available)

Paralogs for HDAC10 Gene

Paralogs for HDAC10 Gene

Selected SIMAP similar genes for HDAC10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HDAC10: view

Variants for HDAC10 Gene

Sequence variations from dbSNP and Humsavar for HDAC10 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs738334 -- 50,249,806(+) TGCGC(C/T)GCCCC intron-variant
rs742182 -- 50,249,807(-) AGGGG(C/T)GGCGC intron-variant
rs909688 -- 50,250,601(+) GATTC(A/G)TGGTG intron-variant
rs1555048 -- 50,249,919(+) AACAC(A/G)CAGAA synonymous-codon, reference
rs2341111 -- 50,251,893(+) CGGAG(C/G)AAGAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HDAC10 Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
dgv5051n71 CNV Loss 21882294
dgv5054n71 CNV Loss 21882294
dgv781n67 CNV Gain 20364138
dgv5055n71 CNV Loss 21882294
dgv5056n71 CNV Loss 21882294
nsv914515 CNV Gain 21882294
nsv471223 CNV Loss 18288195
nsv914517 CNV Loss 21882294
nsv914518 CNV Loss 21882294

Relevant External Links for HDAC10 Gene

HapMap Linkage Disequilibrium report
HDAC10

Disorders for HDAC10 Gene

(1) University of Copenhagen DISEASES for HDAC10 Gene

Relevant External Links for HDAC10

Genetic Association Database (GAD)
HDAC10
Human Genome Epidemiology (HuGE) Navigator
HDAC10
genes like me logo Genes that share disorders with HDAC10: view

No data available for UniProtKB/Swiss-Prot for HDAC10 Gene

Publications for HDAC10 Gene

  1. Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. (PMID: 11677242) Kao H.-Y. … Evans R.M. (J. Biol. Chem. 2002) 2 3 4 23
  2. Molecular cloning and characterization of a novel histone deacetylase HDAC10. (PMID: 11726666) Guardiola A.R. … Yao T.-P. (J. Biol. Chem. 2002) 2 3 4 23
  3. Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. (PMID: 11861901) Tong J.J. … Yang X.-J. (Nucleic Acids Res. 2002) 3 4 23
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  5. Isolation and characterization of a novel class II histone deacetylase, HDAC10. (PMID: 11739383) Fischer D.D. … Cohen D. (J. Biol. Chem. 2002) 3 4

Products for HDAC10 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HDAC10
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HDAC10
    • Block miRNA regulation of HDAC10 using miScript Target Protectors

    Sources for HDAC10 Gene

    Back to Top

    Content