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HDAC10 Gene

protein-coding   GIFtS: 65
GCID: GC22M050683

Histone Deacetylase 10

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Deacetylase 101 2
HD102 3
EC 3.5.1.983

External Ids:    HGNC: 181281   Entrez Gene: 839332   Ensembl: ENSG000001004297   OMIM: 6085445   UniProtKB: Q969S83   

Export aliases for HDAC10 gene to outside databases

Previous GC identifers: GC22M047235 GC22M048865 GC22M048986 GC22M049025 GC22M033581


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HDAC10 Gene:
The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine
residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and
plays an important role in transcriptional regulation, cell cycle progression, and developmental events.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Aug 2011)

GeneCards Summary for HDAC10 Gene:
HDAC10 (histone deacetylase 10) is a protein-coding gene. GO annotations related to this gene include histone deacetylase activity and enzyme binding. An important paralog of this gene is HDAC9.

UniProtKB/Swiss-Prot: HDA10_HUMAN, Q969S8
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A,
H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in
transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the
formation of large multiprotein complexes

summary for HDAC10 Gene:
Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal
of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional
repression. In general, they do not act autonomously but as components of large multiprotein complexes, such
as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of
HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously
expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by
protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the
class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the
nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to
substantial interest in HDAC inhibitors as possible antineoplastic agents.

Gene Wiki entry for HDAC10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011526.8  
Regulatory elements:
   Regulatory transcription factor binding sites in the HDAC10 gene promoter:
         Pax-2   USF2   STAT3   CUTL1   Pax-4a   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HDAC10 promoter sequence
   Search Chromatin IP Primers for HDAC10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HDAC10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.31

HDAC10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDAC10 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M050683:  view genomic region     (about GC identifiers)

Start:
50,683,612 bp from pter      End:
50,689,834 bp from pter
Size:
6,223 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HDA10_HUMAN, Q969S8 (See protein sequence)
Recommended Name: Histone deacetylase 10  
Size: 669 amino acids; 71445 Da
Subunit: Interacts with HDAC2, HDAC3 and NCOR2
Secondary accessions: Q08AP4 Q6STF9 Q96P77 Q96P78 Q9H028 Q9UGX1 Q9UGX2
Alternative splicing: 4 isoforms:  Q969S8-1   Q969S8-2   Q969S8-4   Q969S8-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for HDAC10: NX_Q969S8

Explore proteomics data for HDAC10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys80
  • Modification sites at PhosphoSitePlus

  • See HDAC10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001152758.1  NP_114408.3  

    ENSEMBL proteins: 
     ENSP00000397517   ENSP00000216271   ENSP00000407640   ENSP00000406150   ENSP00000397542  
     ENSP00000343540  
    Reactome Protein details: Q969S8

    HDAC10 Human Recombinant Protein Products:

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    Novus Biologicals HDAC10 Protein
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    Cloud-Clone Corp. Proteins for HDAC10

     
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    antibodies-online proteins for HDAC10 (2 products) 

     
    antibodies-online peptides for HDAC10

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    antibodies-online antibodies for HDAC10 (76 products) 

    HDAC10 Assay Products:

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    Cloud-Clone Corp. ELISAs for HDAC10
    Cloud-Clone Corp. CLIAs for HDAC10
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    antibodies-online kits for HDAC10 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000286 His_deacetylse
     IPR023801 His_deacetylse_dom

    Graphical View of Domain Structure for InterPro Entry Q969S8

    ProtoNet protein and cluster: Q969S8

    1 Blocks protein domain: IPB000286 Histone deacetylase superfamily signature

    UniProtKB/Swiss-Prot: HDA10_HUMAN, Q969S8
    Similarity: Belongs to the histone deacetylase family. HD type 2 subfamily


    Find genes that share domains with HDAC10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HDA10_HUMAN, Q969S8
    Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A,
    H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in
    transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the
    formation of large multiprotein complexes
    Catalytic activity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone

         Enzyme Number (IUBMB): EC 3.5.1.981

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004407histone deacetylase activity IDA11739383
    GO:0005515protein binding IPI17172643
    GO:0016787hydrolase activity ----
    GO:0019899enzyme binding IPI11861901
    GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific) IEA--
         
    Find genes that share ontologies with HDAC10           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for HDAC10:
     Decreased nuclei size in G2M  Decreased viability with cispl  Synthetic lethal with cisplati 

         1 MGI phenotypic allele for Hdac10 (no phenotypes)

    Find genes that share phenotypes with HDAC10           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HDAC10

    miRNA
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    miRTarBase miRNAs that target HDAC10:
    hsa-mir-17-5p (MIRT050881)

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    GenScript: all cDNA clones in your preferred vector (see all 2): HDAC10 (NM_032019)
    Sino Biological Human cDNA Clone for HDAC10
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HDAC10

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDAC10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HDA10_HUMAN, Q969S8: Cytoplasm. Nucleus. Note=Excluded from the nucleoli
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex IDA11861901
    GO:0005634nucleus IDA11739383
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA11726666

    Find genes that share ontologies with HDAC10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HDAC10 About   (see all 23)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1p53 Signaling
    p53 Signaling0.38
    p53 Pathway0.38
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    3Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1-S Phase Transition0.67
    4Macrophage Differentiation and Growth Inhibition by METS
    Macrophage Differentiation and Growth Inhibition by METS0.30
    DNA Methylation and Transcriptional Repression0.30
    5Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with HDAC10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HDAC10 (see all 15)
        DNA Methylation and Transcriptional Repression
    Protein Acetylation and Deacetylation
    BRCA1 Pathway
    Glucocorticoid Receptor Signaling
    Intracellular Calcium Signaling

    3 BioSystems Pathways for HDAC10
        Neural Crest Differentiation
    Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class II

    2 Sino Biological Pathways for HDAC10
        Notch Signaling Pathway
    p53 Pathway

    3 Reactome Pathways for HDAC10
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    Constitutive Signaling by NOTCH1 PEST Domain Mutants


    2 Kegg Pathways  (Kegg details for HDAC10):
        Alcoholism
    Viral carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Array including HDAC10: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HDAC10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HDAC10 (Q969S83 ENSP000002162714) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206481Q146763, ENSP000003730604I2D: score=1 STRING: ENSP00000373060
    ENSG00000224587Q146763I2D: score=1 
    ENSG00000225589Q146763I2D: score=1 
    ENSG00000228575Q146763I2D: score=1 
    ENSG00000231135Q146763I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA11726666
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA11861901
    GO:0006476protein deacetylation IDA17172643
    GO:0007219Notch signaling pathway TAS--

    Find genes that share ontologies with HDAC10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for HDAC10 (see all 29)     About this table
    CompoundAction CAS #
    AR-42 (OSU-HDAC42)Pan-HDAC inhibitor[935881-37-1]
    Belinostat (PXD101)Novel and potent hydroxamate-type HDAC inhibitor[414864-00-9]
    CI994 (Tacedinaline)HDAC1 and 3 inhibitor[112522-64-2]
    CUDC-101Multitargeted HDAC inhibitor[1012054-59-9]
    CUDC-907PI3K and HDAC inhibitor[1339928-25-4]
    DroxinostatSelective HDAC inhibitor[99873-43-5]
    Entinostat (MS-275,SNDX-275)Entinostat inhibits HDAC1 and HDAC3 but not HDAC8[209783-80-2]
    ITF2357 (Givinostat)HDAC inhibitor, inhibits class I and class II HDACs[732302-99-7]
    JNJ-26481585Potent pan-HDAC inhibitor[875320-29-9]
    LAQ824 (NVP-LAQ824,Dacinostat)Novel and potent HDAC inhibitor[404951-53-7]

    Compounds for HDAC10 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TCS HDAC6 20bSelective HDAC6 inhibitor[956154-63-5]
    LMK 235Selective HDAC4/HDAC5 inhibitor[1418033-25-6]
    Trichostatin AHistone deacetylase inhibitor[58880-19-6]
    TubacinHDAC6 inhibitor; inhibits alpha-tubulin deacetylation[1350555-93-9]
    Sodium 4-PhenylbutyrateHistone deacetylase inhibitor[1716-12-7]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HDAC10 gene (2 alternative transcripts): 
    NM_001159286.1  NM_032019.5  

    Unigene Cluster for HDAC10:

    Histone deacetylase 10
    Hs.26593  [show with all ESTs]
    Unigene Representative Sequence: NM_032019
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000415993 ENST00000216271(uc003bkg.3 uc010hav.3 uc003bkh.3 uc003bkj.3)
    ENST00000429374 ENST00000454936 ENST00000448072 ENST00000483222 ENST00000498366
    ENST00000477814 ENST00000349505 ENST00000497952 ENST00000496235 ENST00000471375
    ENST00000475965(uc003bkk.1) ENST00000476310 ENST00000470378 ENST00000496909
    ENST00000488270 ENST00000489424
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    Additional mRNA sequence: 

    AF393962.1 AF407272.1 AF407273.1 AF426160.1 AL512711.1 BC032049.1 BC032423.1 BC094734.1 
    BC125082.1 BC125083.1 CR456465.1 

    23 DOTS entries:

    DT.305807  DT.100844440  DT.101985134  DT.99951089  DT.120663398  DT.91662288  DT.75150891  DT.100825333 
    DT.91756562  DT.99949407  DT.100029495  DT.100825330  DT.97848214  DT.100825329  DT.100839039  DT.95254673 
    DT.97848217  DT.100724402  DT.100800287  DT.100809772  DT.100825332  DT.100836348  DT.101985135 

    Selected AceView cDNA sequences (see all 240):

    AA744814 AA485381 BU585029 AA419610 BC032049 CR625146 BM717754 AW473244 
    BI916349 AF393962 CR456465 AF426160 BM923562 AI205079 NM_032019 BQ644708 
    BE792832 AA808484 AI871004 CR607842 BM821943 AI339683 BQ671006 AL512711 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HDAC10 (see all 27)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a ·
    SP1:                                                        -                             -     -                 -                 -     -                 -   
    SP2:                                                        -                 -     -     -     -                                   -     -                 -   
    SP3:                                                        -                             -     -                 -                 -     -                 -   
    SP4:                                                        -                             -     -                 -                 -     -                 -   
    SP5:                                                  -     -                 -     -     -     -                 -                 -     -                 -   

    ExUns: 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
    SP1:              -                                                                                                                           
    SP2:              -                             -     -                                                                                       
    SP3:              -     -     -                                                                                                               
    SP4:              -     -     -     -     -                                                     -                                             
    SP5:              -                                                                                                                           


    ECgene alternative splicing isoforms for HDAC10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HDAC10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACCCACGC
    HDAC10 Expression
    About this image

    HDAC10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HDAC10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.26593

    UniProtKB/Swiss-Prot: HDA10_HUMAN, Q969S8
    Tissue specificity: Ubiquitous. High expression in liver, spleen, pancreas and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including HDAC10: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HDAC10 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hdac101 , 5 histone deacetylase 101, 5 78.03(n)1
    76.21(a)1
      15 (44.64 cM)5
    1707871  NM_199198.21  NP_954668.21 
     891233075 
    chicken
    (Gallus gallus)
    Aves HDAC101 histone deacetylase 10 53.53(n)
    50.77(a)
      417742  XM_415986.4  XP_415986.4 
    lizard
    (Anolis carolinensis)
    Reptilia HDAC106
    histone deacetylase 10
    51(a)
    1 ↔ 1
    5(64086542-64122204)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL847883.22   -- 74.63(n)    AL847883.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd19e102 wufd19e10 74.17(n)   327253  BC044446.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta HDAC66
    HDAC6
    22(a)
    1 ↔ 1
    X(15227343-15234393)
    worm
    (Caenorhabditis elegans)
    Secernentea Y51H1A.53 Histone deacetylase family 41(a)
    (best of 2)
      II(13882603-13887835)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HDA16
    Putative catalytic subunit of a class II histone d...
    22(a)
    1 → many
    XIV(593227-595347) YNL021W


    ENSEMBL Gene Tree for HDAC10 (if available)
    TreeFam Gene Tree for HDAC10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HDAC10 gene
    HDAC92  HDAC62  HDAC52  HDAC72  HDAC42  
    3 SIMAP similar genes for HDAC10 using alignment to 3 protein entries:     HDA10_HUMAN (see all proteins):
    HDAC9    HDAC6    DKFZp566E044

    Find genes that share paralogs with HDAC10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HDAC10 (see all 285)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2020836271,2
    C--33583125(+) TGTGGG/TATGAA 2 -- int10--------
    rs1116570731,2
    F--33583200(+) CATTCG/AGTGTG 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1469101861,2
    --33583201(+) ATTCGA/GTGTGT 2 -- int10--------
    rs48388661,2
    C,F,A,H--33583231(+) CACACG/ATCTTC 2 -- int129Minor allele frequency- A:0.12NS EA NA WA CSA 2774
    rs664620641,2
    C--33583291(+) ATAATT/-TTTTT 2 -- int11Minor allele frequency- -:0.00NA 2
    rs1833066631,2
    --33583424(+) GTAACA/TACAGG 2 -- int10--------
    rs1889196531,2
    --33583472(+) GTGAAG/TACAGG 2 -- int10--------
    rs772501101,2
    F--33583620(+) CCTCTC/GTGCCA 2 -- int11Minor allele frequency- G:0.02WA 118
    rs1501003481,2
    C--33583645(+) GAAGAA/GGCTGA 2 -- int10--------
    rs581935461,2
    C,F--33583669(+) ACACAC/TTAGTG 2 -- int12Minor allele frequency- T:0.03WA 120

    HapMap Linkage Disequilibrium report for HDAC10 (50683612 - 50689834 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for HDAC10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471223CNV Loss18288195
    nsv915495CNV Loss21882294
    nsv914517CNV Loss21882294
    dgv5055n71CNV Loss21882294
    nsv914518CNV Loss21882294
    dgv5051n71CNV Loss21882294
    dgv5054n71CNV Loss21882294
    dgv5056n71CNV Loss21882294
    dgv781n67CNV Gain20364138
    nsv914515CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608544    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for HDAC10:
    Hodgkin's lymphoma

    Find genes that share disorders with HDAC10           About GenesLikeMe

    Genetic Association Database (GAD): HDAC10
    Human Genome Epidemiology (HuGE) Navigator: HDAC10 (5 documents)

    Export disorders for HDAC10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HDAC10 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with HDAC10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel histone deacetylase HDAC10. (PubMed id 11726666)1, 2, 3, 9 Guardiola A.R. and Yao T.-P. (J. Biol. Chem. 2002)
    2. Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. (PubMed id 11677242)1, 2, 3, 9 Kao H.-Y.... Evans R.M. (J. Biol. Chem. 2002)
    3. Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. (PubMed id 11861901)1, 2, 9 Tong J.J.... Yang X.-J. (Nucleic Acids Res. 2002)
    4. Association of histone deacetylase genes with schizophrenia in Korean population. (PubMed id 20471694)1, 4 Kim T....Kim J.W. (Psychiatry Res 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. HDAC10 promoter polymorphism associated with development of HCC among chronic HBV patients. (PubMed id 17892858)1, 4 Park B.L....Shin H.D. (Biochem. Biophys. Res. Commun. 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    9. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    10. Isolation and characterization of a novel class II histone deacetylase, HDAC10. (PubMed id 11739383)1, 2 Fischer D.D.... Cohen D. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83933 HGNC: 18128 AceView: HDAC10 Ensembl:ENSG00000100429 euGenes: HUgn83933
    ECgene: HDAC10 Kegg: 83933 H-InvDB: HDAC10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HDAC10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HDAC10 gene:
    Search GeneIP for patents involving HDAC10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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