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Aliases for HDAC10 Gene

Aliases for HDAC10 Gene

  • Histone Deacetylase 10 2 3 5
  • HD10 3 4
  • EC 3.5.1.98 4

External Ids for HDAC10 Gene

Previous GeneCards Identifiers for HDAC10 Gene

  • GC22M047235
  • GC22M048865
  • GC22M048986
  • GC22M049025
  • GC22M050683
  • GC22M033581

Summaries for HDAC10 Gene

Entrez Gene Summary for HDAC10 Gene

  • The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for HDAC10 Gene

HDAC10 (Histone Deacetylase 10) is a Protein Coding gene. Among its related pathways are Phospholipase-C Pathway and HIV Life Cycle. GO annotations related to this gene include enzyme binding and histone deacetylase binding. An important paralog of this gene is HDAC6.

UniProtKB/Swiss-Prot for HDAC10 Gene

  • Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Tocris Summary for HDAC10 Gene

  • Histone deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze acetyl group removal from lysine residues in histones and non-histone proteins, causing transcriptional repression. HDACs are usually components of multiprotein complexes.

Gene Wiki entry for HDAC10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDAC10 Gene

Genomics for HDAC10 Gene

Regulatory Elements for HDAC10 Gene

Enhancers for HDAC10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F050188 1.5 FANTOM5 ENCODE 18.7 +60.3 60326 5.6 HDGF PKNOX1 ARID4B SIN3A YBX1 ZNF2 ZNF143 ZNF263 MCM3 SP3 TUBGCP6 MAPK12 ALG12 ZBED4 ENSG00000272836 HDAC10 LOC105373095 LOC101928719 MAPK11 PLXNB2
GH22F050145 1.2 Ensembl ENCODE 12.5 +104.6 104572 2.7 ELF3 ARID4B THRB ZNF48 RAD21 RARA GLIS2 ZNF143 CREM MIXL1 MLC1 MOV10L1 MAPK12 PANX2 TUBGCP6 HDAC10 SELENOO MAPK11 PLXNB2 ENSG00000280395
GH22F050148 1.1 Ensembl ENCODE 12.5 +102.3 102295 1.0 DRAP1 CTCF HDAC1 SAP130 TAL1 ARID4B MAX SIN3A ZNF48 ZIC2 MLC1 MOV10L1 PANX2 TUBGCP6 HDAC10 SELENOO MAPK12 MAPK11 PLXNB2 TRABD
GH22F050199 1 ENCODE 12.1 +50.4 50376 2.9 ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 FOS SP3 LOC101928719 SELENOO TUBGCP6 HDAC10 MAPK12 MAPK11 PLXNB2 MLC1 TRABD ALG12
GH22F049851 1.4 FANTOM5 ENCODE 7.4 +397.6 397613 5.1 HDGF MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LOC105377205 DENND6B HDAC10 CRELD2 TUBGCP6 ZBED4 BRD1 PIM3 SELENOO TRABD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HDAC10 on UCSC Golden Path with GeneCards custom track

Promoters for HDAC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000620195 205 1201 ARID4B SIN3A ZNF48 BRCA1 DNMT3B ZNF2 ZNF121 SLC30A9 GLIS2 SP3

Genomic Location for HDAC10 Gene

Chromosome:
22
Start:
50,245,183 bp from pter
End:
50,251,405 bp from pter
Size:
6,223 bases
Orientation:
Minus strand

Genomic View for HDAC10 Gene

Genes around HDAC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDAC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDAC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDAC10 Gene

Proteins for HDAC10 Gene

  • Protein details for HDAC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969S8-HDA10_HUMAN
    Recommended name:
    Histone deacetylase 10
    Protein Accession:
    Q969S8
    Secondary Accessions:
    • Q08AP4
    • Q6STF9
    • Q96P77
    • Q96P78
    • Q9H028
    • Q9UGX1
    • Q9UGX2

    Protein attributes for HDAC10 Gene

    Size:
    669 amino acids
    Molecular mass:
    71445 Da
    Quaternary structure:
    • Interacts with HDAC2, HDAC3 and NCOR2.

    Alternative splice isoforms for HDAC10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDAC10 Gene

Post-translational modifications for HDAC10 Gene

  • Ubiquitination at Lys 80
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HDAC10 Gene

Domains & Families for HDAC10 Gene

Gene Families for HDAC10 Gene

Protein Domains for HDAC10 Gene

Suggested Antigen Peptide Sequences for HDAC10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969S8

UniProtKB/Swiss-Prot:

HDA10_HUMAN :
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
Family:
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
genes like me logo Genes that share domains with HDAC10: view

Function for HDAC10 Gene

Molecular function for HDAC10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
UniProtKB/Swiss-Prot Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Enzyme Numbers (IUBMB) for HDAC10 Gene

Gene Ontology (GO) - Molecular Function for HDAC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004407 histone deacetylase activity TAS --
GO:0005515 protein binding IPI 17172643
GO:0016787 hydrolase activity IEA --
GO:0019899 enzyme binding IPI 11861901
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA --
genes like me logo Genes that share ontologies with HDAC10: view
genes like me logo Genes that share phenotypes with HDAC10: view

Animal Models for HDAC10 Gene

MGI Knock Outs for HDAC10:

Animal Model Products

  • Taconic Biosciences Mouse Models for HDAC10

miRNA for HDAC10 Gene

miRTarBase miRNAs that target HDAC10

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HDAC10 Gene

Localization for HDAC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDAC10 Gene

Cytoplasm. Nucleus. Note=Excluded from the nucleoli.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDAC10 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HDAC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IDA 11861901
GO:0005634 nucleus IEA,IDA 11861901
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 11726666
genes like me logo Genes that share ontologies with HDAC10: view

Pathways & Interactions for HDAC10 Gene

genes like me logo Genes that share pathways with HDAC10: view

Gene Ontology (GO) - Biological Process for HDAC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11726666
GO:0006325 chromatin organization NAS 11861901
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 11861901
GO:0006476 protein deacetylation IDA 17172643
genes like me logo Genes that share ontologies with HDAC10: view

No data available for SIGNOR curated interactions for HDAC10 Gene

Drugs & Compounds for HDAC10 Gene

(22) Drugs for HDAC10 Gene - From: DrugBank, ApexBio, DGIdb, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Belinostat Approved, Investigational Pharma Inhibitor, Target Histone deacetylase (HDAC)inhibitors 42
Panobinostat Approved, Investigational Pharma Inhibition, inhibitor, Target Histone deacetylase (HDAC)inhibitors 136
Romidepsin Approved, Investigational Pharma inhibitor Histone deacetylase (HDAC)inhibitors 84
Vorinostat Approved, Investigational Pharma inhibitor HDAC inhibitor, Histone deacetylase (HDAC)inhibitors 242
CRA-024781 Investigational Pharma 0

(3) Additional Compounds for HDAC10 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FK 228
128517-07-7
MC 1742
1776116-74-5
SAHA
149647-78-9

(5) Tocris Compounds for HDAC10 Gene

Compound Action Cas Number
FK 228 Potent and selective class I histone deacetylase inhibitor; antitumor 128517-07-7
MC 1568 Selective HDAC class II (IIa) inhibitor 852475-26-4
MC 1742 Potent class I and IIb HDAC inhibitor 1776116-74-5
SAHA Class I and II HDAC inhibitor 149647-78-9
Trichostatin A Potent histone deacetylase inhibitor 58880-19-6

(6) ApexBio Compounds for HDAC10 Gene

Compound Action Cas Number
Chidamide Novel HDAC inhibitor 743420-02-2
CUDC-907 Potent PI3K/HDAC inhibitor 1339928-25-4
JNJ-26481585 Potent HDAC inhibitor 875320-29-9
MC1568 Class II HDAC inhibitor,potent and 852475-26-4
PCI-24781 (CRA-024781) Pan-HDAC inhibitor 783355-60-2
Pracinostat (SB939) Pan-HDAC inhibitor 929016-96-6
genes like me logo Genes that share compounds with HDAC10: view

Transcripts for HDAC10 Gene

Unigene Clusters for HDAC10 Gene

Histone deacetylase 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDAC10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - - -
SP14: -
SP15: - - - - - -
SP16: - - - - - - - -
SP17: - - -
SP18:
SP19:
SP20: - - -
SP21: - - - - - -
SP22:
SP23: -
SP24:
SP25:
SP26:
SP27:

ExUns: 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6: -
SP7: - - - -
SP8: - -
SP9: - -
SP10:
SP11: -
SP12: - - - -
SP13: - - - - -
SP14: - - - - -
SP15:
SP16:
SP17: - - - - -
SP18: - -
SP19: -
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

Relevant External Links for HDAC10 Gene

GeneLoc Exon Structure for
HDAC10
ECgene alternative splicing isoforms for
HDAC10

Expression for HDAC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HDAC10 Gene

Protein differential expression in normal tissues from HIPED for HDAC10 Gene

This gene is overexpressed in Lung (39.5), Heart (13.1), and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HDAC10 Gene



Protein tissue co-expression partners for HDAC10 Gene

NURSA nuclear receptor signaling pathways regulating expression of HDAC10 Gene:

HDAC10

SOURCE GeneReport for Unigene cluster for HDAC10 Gene:

Hs.26593

mRNA Expression by UniProt/SwissProt for HDAC10 Gene:

Q969S8-HDA10_HUMAN
Tissue specificity: Ubiquitous. High expression in liver, spleen, pancreas and kidney.
genes like me logo Genes that share expression patterns with HDAC10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HDAC10 Gene

Orthologs for HDAC10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HDAC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDAC10 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia HDAC10 34 35
  • 82.75 (n)
dog
(Canis familiaris)
Mammalia HDAC10 34 35
  • 82.04 (n)
mouse
(Mus musculus)
Mammalia Hdac10 34 16 35
  • 78.03 (n)
rat
(Rattus norvegicus)
Mammalia Hdac10 34
  • 76.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia HDAC10 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves HDAC10 34 35
  • 53.53 (n)
lizard
(Anolis carolinensis)
Reptilia HDAC10 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdac10 34
  • 52.5 (n)
zebrafish
(Danio rerio)
Actinopterygii hdac10 34 35
  • 54.96 (n)
wufd19e10 34
fruit fly
(Drosophila melanogaster)
Insecta HDAC6 35
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y51H1A.5 36
  • 41 (a)
F43G6.4 36
  • 33 (a)
hda-10 35
  • 29 (a)
OneToMany
hda-5 35
  • 27 (a)
OneToMany
F43G6.17 35
  • 23 (a)
OneToMany
hda-6 35
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HDA1 35
  • 22 (a)
OneToMany
Species where no ortholog for HDAC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDAC10 Gene

ENSEMBL:
Gene Tree for HDAC10 (if available)
TreeFam:
Gene Tree for HDAC10 (if available)

Paralogs for HDAC10 Gene

Paralogs for HDAC10 Gene

(3) SIMAP similar genes for HDAC10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HDAC10: view

Variants for HDAC10 Gene

Sequence variations from dbSNP and Humsavar for HDAC10 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs111248040 -- 50,246,622(+) CACGT(C/T)CATCA intron-variant, upstream-variant-2KB
rs111345994 -- 50,248,782(+) GGGAC(C/T)TGGGC intron-variant
rs111440214 -- 50,248,618(+) CCCCA(A/G)GCCTC intron-variant
rs111554707 -- 50,245,319(+) CGGGG(C/G)CGAGG upstream-variant-2KB, utr-variant-3-prime
rs111657073 -- 50,247,048(+) CATTC(A/G)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDAC10 Gene

Variant ID Type Subtype PubMed ID
nsv955199 CNV deletion 24416366
nsv471223 CNV loss 18288195
nsv1066496 CNV loss 25217958
dgv781n67 CNV gain 20364138

Variation tolerance for HDAC10 Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HDAC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HDAC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDAC10 Gene

Disorders for HDAC10 Gene

Relevant External Links for HDAC10

Genetic Association Database (GAD)
HDAC10
Human Genome Epidemiology (HuGE) Navigator
HDAC10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HDAC10

No disorders were found for HDAC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDAC10 Gene

Publications for HDAC10 Gene

  1. Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. (PMID: 11677242) Kao H.-Y. … Evans R.M. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. Molecular cloning and characterization of a novel histone deacetylase HDAC10. (PMID: 11726666) Guardiola A.R. … Yao T.-P. (J. Biol. Chem. 2002) 2 3 4 22 64
  3. Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. (PMID: 11861901) Tong J.J. … Yang X.-J. (Nucleic Acids Res. 2002) 3 4 22 64
  4. Histone deacetylase 10 relieves repression on the melanogenic program by maintaining the deacetylation status of repressors. (PMID: 20032463) Lai I.L. … Yang W.M. (J. Biol. Chem. 2010) 3 22 64
  5. Association of histone deacetylase genes with schizophrenia in Korean population. (PMID: 20471694) Kim T. … Kim J.W. (Psychiatry Res 2010) 3 46 64

Products for HDAC10 Gene

Sources for HDAC10 Gene

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