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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HDAC10 Gene

protein-coding GIFtS: 62
GCID: GC22M050683

histone deacetylase 10

Explore 6 diseases affiliated with
HDAC10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Histone Deacetylase 10¹ ²
HD10² ³
DKFZP761B039¹
EC 3.5.1.98³

External Ids:	HGNC: 18128¹	Entrez Gene: 83933²	Ensembl: ENSG00000100429⁷	OMIM: 608544⁵	UniProtKB: Q969S8³

Export aliases for HDAC10 gene to outside databases

Previous GC identifers: GC22M047235 GC22M048865 GC22M048986 GC22M049025 GC22M033581

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HDAC10:

The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine

residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays

an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively

spliced transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: HDA10_HUMAN, Q969S8

Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B,

H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional

regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large

multiprotein complexes

summary for HDAC10:

Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal

of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional

repression. In general, they do not act autonomously but as components of large multiprotein complexes, such

as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of

HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously

expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by

protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the

class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the

nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to

substantial interest in HDAC inhibitors as possible antineoplastic agents.

Gene Wiki entry for HDAC10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011526.7

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HDAC10 gene promoter:
Pax-2 USF2 STAT3 CUTL1 Pax-4a NF-kappaB1 NF-kappaB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HDAC10 promoter sequence

Search SABiosciences Chromatin IP Primers for HDAC10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HDAC10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31 Ensembl cytogenetic band: 22q13.33 HGNC cytogenetic band: 22q13.31

HDAC10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDAC10 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M050683: view genomic region (about GC identifiers)

Start:	50,683,612 bp from pter	End:	50,689,834 bp from pter
Size:	6,223 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HDA10_HUMAN, Q969S8 (See protein sequence)

Recommended Name: Histone deacetylase 10

Size: 669 amino acids; 71445 Da

Subunit: Interacts with HDAC2, HDAC3 and NCOR2

Subcellular location: Cytoplasm. Nucleus. Note=Excluded from the nucleoli

Secondary accessions: Q08AP4 Q6STF9 Q96P77 Q96P78 Q9H028 Q9UGX1 Q9UGX2

Alternative splicing: 4 isoforms: Q969S8-1 Q969S8-2 Q969S8-4 Q969S8-5 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for HDAC10: NX_Q969S8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q969S8

HDAC10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001152758.1 NP_114408.3

ENSEMBL proteins:

ENSP00000397517 ENSP00000216271 ENSP00000407640 ENSP00000406150 ENSP00000397542

ENSP00000343540

Reactome Protein details: Q969S8
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Enzo Life Sciences proteins for HDAC10
	OriGene Purified Protein: HDAC10 OriGene Protein Over-expression Lysate (see all 2): HDAC10 OriGene Custom Protein Services for HDAC10
	GenScript Custom Purified and Recombinant Proteins Services for HDAC10
	Novus Biologicals HDAC10 Protein Novus Biologicals HDAC10 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HDAC10

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000118	histone deacetylase complex	IDA	11861901
GO:0005634	nucleus	IDA	11739383
GO:0005654	nucleoplasm	IDA	11726666
GO:0005737	cytoplasm	IDA	11726666

HDAC10 for ontologies About GeneDecksing

HDAC10 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HDAC10
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 12): HDAC10 OriGene Custom Antibody Services for HDAC10
	GenScript Custom Superior Antibodies Services for HDAC10
	Novus Biologicals HDAC10 Antibodies
	Abcam antibodies for HDAC10
	Uscn Antibodies for HDAC10
	ThermoFisher Antibodies for HDAC10

Assay Products for HDAC10:

	EMD Millipore Kits and Assays for the Analysis of HDAC10
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HDAC10
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HDAC10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HDAC10 for domains About GeneDecksing

2 InterPro domains/families:

IPR000286 His_deacetylse

IPR023801 His_deacetylse_dom

Graphical View of Domain Structure for InterPro Entry Q969S8

ProtoNet protein and cluster: Q969S8

1 Blocks protein family: IPB000286 Histone deacetylase superfamily signature

UniProtKB/Swiss-Prot: HDA10_HUMAN, Q969S8

Similarity: Belongs to the histone deacetylase family. HD type 2 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HDA10_HUMAN, Q969S8

Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B,

H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional

regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large

multiprotein complexes

Catalytic activity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone

Enzyme Number (IUBMB): EC 3.5.1.98¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HDAC10 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HDAC10
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for HDAC10

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HDAC10
		Search LifeMap BioReagents cell lines for HDAC10

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDAC10

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004407	histone deacetylase activity	IDA	11739383
GO:0005515	protein binding	IPI	17172643
GO:0016787	hydrolase activity	--	--
GO:0019899	enzyme binding	IPI	11861901
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	IEA	--

HDAC10 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for HDAC10:

Decreased nuclei size in G2M

Decreased viability with cispl

Synthetic lethal with cisplati

Animal Models:
1 MGI phenotypic allele

for Hdac10 (no phenotypes)

HDAC10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant

8/12 pathways (see all 12)
Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant	1.00	Signaling by NOTCH1	1.00
Signaling by NOTCH1 PEST Domain Mutants in Cancer	1.00	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.79
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	1.00	Signaling by NOTCH	0.77
Signaling by NOTCH1 in Cancer	1.00	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.71

DNA Methylation and Transcriptional Repression

DNA Methylation and Transcriptional Repression

1.00

Macrophage Differentiation and Growth Inhibition by METS

0.30

Cyclins and Cell Cycle Regulation

Cyclins and Cell Cycle Regulation

1.00

G1-S Phase Transition

0.67

Disease

Disease

1.00

BRCA1 Pathway

BRCA1 Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for HDAC10

Histone modification

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HDAC10 (see all 15)

	DNA Methylation and Transcriptional Repression
	Protein Acetylation and Deacetylation
	BRCA1 Pathway
	Glucocorticoid Receptor Signaling
	Intracellular Calcium Signaling

3 BioSystems Pathways for HDAC10

	Neural Crest Differentiation
	Signaling events mediated by HDAC Class II
	Signaling events mediated by HDAC Class I

5/13 Reactome Pathways for HDAC10 (see all 13)

	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	NOTCH1 Intracellular Domain Regulates Transcription
	Signaling by NOTCH
	FBXW7 Mutants and NOTCH1 in Cancer
	Signaling by NOTCH1 HD Domain Mutants in Cancer

HDAC10 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HDAC10

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/69 Interacting proteins for HDAC10 (Q969S8³ ENSP00000216271⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 69)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PAPOLA	P51003³, ENSP00000216277⁴	I2D: score=1 STRING: ENSP00000216277
PPP1CC	P36873³, ENSP00000335084⁴	I2D: score=1 STRING: ENSP00000335084
TRIM28	Q13263³, ENSP00000253024⁴	I2D: score=1 STRING: ENSP00000253024
HDAC3	O15379³, ENSP00000302967⁴	I2D: score=3 STRING: ENSP00000302967
HDAC2	Q92769³, ENSP00000381331⁴	I2D: score=2 STRING: ENSP00000381331

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	11726666
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IDA	11861901
GO:0006476	protein deacetylation	IDA	17172643
GO:0007219	Notch signaling pathway	TAS	--

HDAC10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for HDAC10:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for HDAC10 available from Tocris Bioscience About this table

Compound	Action	CAS #
NCH 51	Histone deacetylase inhibitor	[848354-66-5]
Splitomicin	Sir2p inhibitor	[5690-03-9]
Trichostatin A	Histone deacetylase inhibitor	[58880-19-6]
KD 5170	Histone deacetylase inhibitor	[940943-37-3]
Sodium 4-Phenylbutyrate	Histone deacetylase inhibitor	[1716-12-7]

Search CenterWatch for drugs/clinical trials and news about HDAC10 / HDA10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HDAC10 gene (2 alternative transcripts):

NM_001159286.1 NM_032019.5

Unigene Cluster for HDAC10:

Histone deacetylase 10

Hs.26593 [show with all ESTs]

Unigene Representative Sequence: NM_032019

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000415993 ENST00000216271(uc003bkg.3 uc010hav.3 uc003bkh.3 uc003bkj.3)

ENST00000429374 ENST00000454936 ENST00000448072 ENST00000483222 ENST00000498366

ENST00000477814 ENST00000349505 ENST00000497952 ENST00000496235 ENST00000471375

ENST00000475965(uc003bkk.1) ENST00000476310 ENST00000470378 ENST00000496909

ENST00000488270 ENST00000489424

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HDAC10 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HDAC10
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HDAC10
		SwitchGear 3'UTR luciferase reporter plasmid: HDAC10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HDAC10 (see all 7) OriGene shRNA RFP: HDAC10 OriGene siRNA: HDAC10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HDAC10

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HDAC10 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HDAC10 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HDAC10 (NM_032019)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HDAC10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDAC10

Additional cDNA sequence:

AF393962.1 AF407272.1 AF407273.1 AF426160.1 AL512711.1 BC032049.1 BC032423.1 BC094734.1

BC125082.1 BC125083.1 CR456465.1

23 DOTS entries:

DT.305807 DT.100844440 DT.101985134 DT.99951089 DT.120663398 DT.91662288 DT.75150891 DT.100825333

DT.91756562 DT.99949407 DT.100029495 DT.100825330 DT.97848214 DT.100825329 DT.100839039 DT.95254673

DT.97848217 DT.100724402 DT.100800287 DT.100809772 DT.100825332 DT.100836348 DT.101985135

24/240 AceView cDNA sequences (see all 240):

BQ654202 CR607842 CR456465 AI205079 AI339683 BE792832 BI759439 BQ643658

BI490004 BX328558 AF407272 BI438929 BQ049093 AI493404 AL512711 CR625146

AW473244 BQ064495 BI916349 BQ644708 BC032049 BM923562 AA419610 AF393962

GeneLoc Exon Structure

5/27 Alternative Splicing Database (ASD) splice patterns (SP) for HDAC10 (see all 27) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	·	1h	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	·	8c	^	9a	·
SP1:																			-										-		-						-						-		-						-
SP2:																			-						-		-		-		-												-		-						-
SP3:																			-										-		-						-						-		-						-
SP4:																			-										-		-						-						-		-						-
SP5:																	-		-						-		-		-		-						-						-		-						-

ExUns:	9b	·	9c	^	10a	·	10b	·	10c	^	11a	·	11b	^	12	^	13	^	14	^	15a	·	15b	·	15c	·	15d	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23a	·	23b
SP1:					-
SP2:					-										-		-
SP3:					-		-		-
SP4:					-		-		-		-		-																		-
SP5:					-

ECgene alternative splicing isoforms for HDAC10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HDAC10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAACCCACGC

About this image
See HDAC10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HDAC10

SOURCE GeneReport for Unigene cluster: Hs.26593

UniProtKB/Swiss-Prot: HDA10_HUMAN, Q969S8

Tissue specificity: Ubiquitous. High expression in liver, spleen, pancreas and kidney

SABiosciences Expression via Pathway-Focused PCR Array including HDAC10:

Epigenetic Chromatin Modification Enzymes in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HDAC10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HDAC10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HDAC10 gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HDAC10¹	histone deacetylase 10	53.7(n) 51.93(a)		417742 XM_415986.3 XP_415986.3
lizard (Anolis carolinensis)	Reptilia	HDAC10⁶	--	48(a)	1 ↔ 1	5(64086376-64122204)
tropical clawed frog (Xenopus tropicalis)	Amphibia	AL847883.2²	--	74.63(n)		AL847883.2
zebrafish (Danio rerio)	Actinopterygii	wufd19e10²	wufd19e10	74.17(n)		327253 BC044446.1
fruit fly (Drosophila melanogaster)	Insecta	HDAC6⁶	HDAC6	21(a)	1 → many	X(15227343-15234393)
worm (Caenorhabditis elegans)	Secernentea	Y51H1A.5³	Histone deacetylase family	41(a) (best of 2)		II(13882603-13887835) --
thale cress (Arabidopsis thaliana)	eudicotyledons	HDA15⁶ hda14⁶ (see all 5)	histone deacetylase 14 (see all 5)	26(a) 25(a) (see all 5)	many ↔ many possible ortholog (see all 5)	3(6361176-6365615) 4(16102595-16105493)
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	histone deacetylase, putative, expressed (see all 5)	24(a) 23(a) (see all 5)	possible ortholog many ↔ many (see all 5)	12(4192936-4197866) 7(24591010-24597360)

ENSEMBL Gene Tree for HDAC10 (if available)
TreeFam Gene Tree for HDAC10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HDAC10 gene

HDAC9² HDAC6² HDAC5² HDAC4² HDAC7²

3 SIMAP similar genes for HDAC10 using alignment to 3 protein entries: HDA10_HUMAN (see all proteins):

HDAC9 HDAC6 DKFZp566E044

HDAC10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs13054930^1,2	C	--	33582064(+)	`TACCTC/GCTCCA`	4	Q E	mis¹ ese³		0	--	--	--	--
rs182113508^1,2	C,	--	33582586(+)	`AAACCA/GCAGAG`	2	--	int¹		0	--	--	--	--
rs76980022^1,2	F,	--	33582691(+)	`CCCTTC/GTCCCA`	2	--	int¹		1		NA	120
rs111657073^1,2		--	33583200(+)	`CATTCG/AGTGTG`	2	--	int¹		1		CSA	2
rs66462064^1,2	C	--	33583291(+)	`ATAATT/-TTTTT`	2	--	int¹		1		NA	2
rs77250110^1,2	F,	--	33583620(+)	`CCTCTC/GTGCCA`	2	--	int¹		1		WA	118
rs58193546^1,2	C,	--	33583669(+)	`ACACAC/TTAGTG`	2	--	int¹		2		WA	120
rs115053950^1,2	C,F,	--	33583704(+)	`GGAACA/GGTTCC`	2	--	int¹		1		WA	118
rs742182^1,2		--	33586203(-)	`AGGGGC/TGGCGC`	2	--	int¹		0	--	--	--	--
rs73893147^1,2	C,	--	33586670(+)	`CCAGCC/TCCAGG`	2	--	int¹		2		WA	120

HapMap Linkage Disequilibrium report for HDAC10 (50683612 - 50689834 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HDAC10
1 CNV: 30166

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HDAC10

DNA2.0 Custom Variant and Variant Library Synthesis for HDAC10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HDAC10 for disorders           About GeneDecksing

OMIM gene information: 608544    OMIM disorders: --

6 diseases for HDAC10:    About MalaCards

lung giant cell carcinoma hodgkin's lymphoma gastric cancer lung cancer

carcinoma huntington's disease

1 disease from the University of Copenhagen DISEASES database for HDAC10:

Hodgkin's lymphoma

Human Genome Epidemiology (HuGE) Navigator: HDAC10 (5 documents)

Export disorders for HDAC10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HDAC10 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with HDAC10)

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Molecular cloning and characterization of a novel histone deacetylase HDAC10. (PubMed id 11726666)^{1, 2, 3, 9} Guardiola A.R. and Yao T.-P. (2002)
Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. (PubMed id 11677242)^{1, 2, 3, 9} Kao H.-Y.... Evans R.M. (2002)
Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. (PubMed id 11861901)^{1, 2, 9} Tong J.J.... Yang X.-J. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (2004)
Isolation and characterization of a novel class II histone deacetylase, HDAC10. (PubMed id 11739383)^{1, 2} Fischer D.D.... Cohen D. (2002)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Histone deacetylase 10 relieves repression on the mel anogenic program by maintaining the deacetylation status of repressors. (PubMed id 20032463)^{1, 9} Lai I.L....Yang W.M. (2010)
Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. (PubMed id 17172643)^{1, 9} Shimazu T.... Yoshida M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 83933	HGNC: 18128	AceView: HDAC10	Ensembl:ENSG00000100429	euGenes: HUgn83933
ECgene: HDAC10	H-InvDB: HDAC10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HDAC10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HDAC10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HDAC10 gene:
Search GeneIP for patents involving HDAC10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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histone deacetylase 10

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