External Ids for HDAC10 Gene
Previous GeneCards Identifiers for HDAC10 Gene
The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for HDAC10 Gene
HDAC10 (Histone Deacetylase 10) is a Protein Coding gene. Among its related pathways are SMAD Signaling Network and Signaling by NOTCH1. GO annotations related to this gene include enzyme binding and histone deacetylase binding. An important paralog of this gene is HDAC6.
UniProtKB/Swiss-Prot for HDAC10 Gene
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Histone deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze acetyl group removal from lysine residues in histones and non-histone proteins, causing transcriptional repression. HDACs are usually components of multiprotein complexes.