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Aliases for HDAC10 Gene

Aliases for HDAC10 Gene

  • Histone Deacetylase 10 2 3 5
  • HD10 3 4
  • EC 3.5.1.98 4

External Ids for HDAC10 Gene

Previous GeneCards Identifiers for HDAC10 Gene

  • GC22M047235
  • GC22M048865
  • GC22M048986
  • GC22M049025
  • GC22M050683
  • GC22M033581

Summaries for HDAC10 Gene

Entrez Gene Summary for HDAC10 Gene

  • The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for HDAC10 Gene

HDAC10 (Histone Deacetylase 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include enzyme binding and histone deacetylase binding. An important paralog of this gene is HDAC4.

UniProtKB/Swiss-Prot for HDAC10 Gene

  • Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Tocris Summary for HDAC10 Gene

  • Histone deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze acetyl group removal from lysine residues in histones and non-histone proteins, causing transcriptional repression. HDACs are usually components of multiprotein complexes.

Gene Wiki entry for HDAC10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDAC10 Gene

Genomics for HDAC10 Gene

Regulatory Elements for HDAC10 Gene

Promoters for HDAC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HDAC10 on UCSC Golden Path with GeneCards custom track

Genomic Location for HDAC10 Gene

Chromosome:
22
Start:
50,245,183 bp from pter
End:
50,251,405 bp from pter
Size:
6,223 bases
Orientation:
Minus strand

Genomic View for HDAC10 Gene

Genes around HDAC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDAC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDAC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDAC10 Gene

Proteins for HDAC10 Gene

  • Protein details for HDAC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969S8-HDA10_HUMAN
    Recommended name:
    Histone deacetylase 10
    Protein Accession:
    Q969S8
    Secondary Accessions:
    • Q08AP4
    • Q6STF9
    • Q96P77
    • Q96P78
    • Q9H028
    • Q9UGX1
    • Q9UGX2

    Protein attributes for HDAC10 Gene

    Size:
    669 amino acids
    Molecular mass:
    71445 Da
    Quaternary structure:
    • Interacts with HDAC2, HDAC3 and NCOR2.

    Alternative splice isoforms for HDAC10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDAC10 Gene

Proteomics data for HDAC10 Gene at MOPED

Post-translational modifications for HDAC10 Gene

  • Ubiquitination at Lys 80
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HDAC10 Gene

Domains & Families for HDAC10 Gene

Gene Families for HDAC10 Gene

Protein Domains for HDAC10 Gene

Suggested Antigen Peptide Sequences for HDAC10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969S8

UniProtKB/Swiss-Prot:

HDA10_HUMAN :
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
Family:
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
genes like me logo Genes that share domains with HDAC10: view

Function for HDAC10 Gene

Molecular function for HDAC10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
UniProtKB/Swiss-Prot Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Enzyme Numbers (IUBMB) for HDAC10 Gene

Gene Ontology (GO) - Molecular Function for HDAC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA --
genes like me logo Genes that share ontologies with HDAC10: view
genes like me logo Genes that share phenotypes with HDAC10: view

Animal Models for HDAC10 Gene

MGI Knock Outs for HDAC10:

Animal Model Products

miRNA for HDAC10 Gene

miRTarBase miRNAs that target HDAC10

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HDAC10 Gene

Localization for HDAC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDAC10 Gene

Cytoplasm. Nucleus. Note=Excluded from the nucleoli.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HDAC10 Gene COMPARTMENTS Subcellular localization image for HDAC10 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HDAC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11726666
genes like me logo Genes that share ontologies with HDAC10: view

Pathways & Interactions for HDAC10 Gene

genes like me logo Genes that share pathways with HDAC10: view

Pathways by source for HDAC10 Gene

Gene Ontology (GO) - Biological Process for HDAC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11726666
GO:0006351 transcription, DNA-templated IEA --
GO:0006476 protein deacetylation IDA 17172643
GO:0007219 Notch signaling pathway TAS --
GO:0014003 oligodendrocyte development IEA --
genes like me logo Genes that share ontologies with HDAC10: view

No data available for SIGNOR curated interactions for HDAC10 Gene

Drugs & Compounds for HDAC10 Gene

(24) Drugs for HDAC10 Gene - From: Tocris, DGIdb, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Belinostat Approved, Investigational Pharma Inhibitor Histone deacetylase (HDAC)inhibitors 41
Vorinostat Approved, Investigational Pharma inhibitor HDAC inhibitor, Histone deacetylase (HDAC)inhibitors 238
CRA-024781 Investigational Pharma 0
MGCD-0103 Investigational Pharma inhibitor 0
CUDC-907 Pharma Potent PI3K/HDAC inhibitor 0

(2) Additional Compounds for HDAC10 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NSC 3852
3565-26-2
Sodium 4-Phenylbutyrate
1716-12-7
genes like me logo Genes that share compounds with HDAC10: view

Transcripts for HDAC10 Gene

Unigene Clusters for HDAC10 Gene

Histone deacetylase 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HDAC10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - - -
SP14: -
SP15: - - - - - -
SP16: - - - - - - - -
SP17: - - -
SP18:
SP19:
SP20: - - -
SP21: - - - - - -
SP22:
SP23: -
SP24:
SP25:
SP26:
SP27:

ExUns: 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6: -
SP7: - - - -
SP8: - -
SP9: - -
SP10:
SP11: -
SP12: - - - -
SP13: - - - - -
SP14: - - - - -
SP15:
SP16:
SP17: - - - - -
SP18: - -
SP19: -
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

Relevant External Links for HDAC10 Gene

GeneLoc Exon Structure for
HDAC10
ECgene alternative splicing isoforms for
HDAC10

Expression for HDAC10 Gene

mRNA expression in normal human tissues for HDAC10 Gene

Protein differential expression in normal tissues from HIPED for HDAC10 Gene

This gene is overexpressed in Lung (39.5), Heart (13.1), and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HDAC10 Gene



SOURCE GeneReport for Unigene cluster for HDAC10 Gene Hs.26593

mRNA Expression by UniProt/SwissProt for HDAC10 Gene

Q969S8-HDA10_HUMAN
Tissue specificity: Ubiquitous. High expression in liver, spleen, pancreas and kidney.
genes like me logo Genes that share expression patterns with HDAC10: view

Protein tissue co-expression partners for HDAC10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HDAC10 Gene

Orthologs for HDAC10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HDAC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDAC10 35
  • 99.35 (n)
  • 99.1 (a)
HDAC10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HDAC10 36
  • 79 (a)
OneToOne
HDAC10 35
  • 82.75 (n)
  • 80.33 (a)
dog
(Canis familiaris)
Mammalia HDAC10 35
  • 82.04 (n)
  • 79.06 (a)
HDAC10 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hdac10 16
Hdac10 35
  • 78.03 (n)
  • 76.21 (a)
Hdac10 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HDAC10 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hdac10 35
  • 76.99 (n)
  • 75.04 (a)
chicken
(Gallus gallus)
Aves HDAC10 36
  • 48 (a)
OneToOne
HDAC10 35
  • 53.53 (n)
  • 50.77 (a)
lizard
(Anolis carolinensis)
Reptilia HDAC10 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdac10 35
  • 52.5 (n)
  • 50.15 (a)
zebrafish
(Danio rerio)
Actinopterygii hdac10 35
  • 54.96 (n)
  • 47.46 (a)
wufd19e10 35
hdac10 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HDAC6 36
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F43G6.4 37
  • 33 (a)
Y51H1A.5 37
  • 41 (a)
F43G6.17 36
  • 23 (a)
OneToMany
hda-10 36
  • 29 (a)
OneToMany
hda-5 36
  • 27 (a)
OneToMany
hda-6 36
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HDA1 36
  • 22 (a)
OneToMany
Species with no ortholog for HDAC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDAC10 Gene

ENSEMBL:
Gene Tree for HDAC10 (if available)
TreeFam:
Gene Tree for HDAC10 (if available)

Paralogs for HDAC10 Gene

Paralogs for HDAC10 Gene

(3) SIMAP similar genes for HDAC10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HDAC10: view

Variants for HDAC10 Gene

Sequence variations from dbSNP and Humsavar for HDAC10 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_015067 -
rs34402301 - 50,247,942(+) GATGA(C/T)GTCAG reference, missense
rs738334 -- 50,249,806(+) TGCGC(C/T)GCCCC intron-variant
rs4838866 -- 50,247,079(+) CACAC(A/G)TCTTC intron-variant
rs11553698 -- 50,248,881(-) ACCCT(G/T)AGCTG intron-variant, reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for HDAC10 Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
dgv5051n71 CNV Loss 21882294
dgv5054n71 CNV Loss 21882294
dgv781n67 CNV Gain 20364138
dgv5055n71 CNV Loss 21882294
dgv5056n71 CNV Loss 21882294
nsv914515 CNV Gain 21882294
nsv471223 CNV Loss 18288195
nsv914517 CNV Loss 21882294
nsv914518 CNV Loss 21882294

Variation tolerance for HDAC10 Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HDAC10 Gene

HapMap Linkage Disequilibrium report
HDAC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDAC10 Gene

Disorders for HDAC10 Gene

Relevant External Links for HDAC10

Genetic Association Database (GAD)
HDAC10
Human Genome Epidemiology (HuGE) Navigator
HDAC10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HDAC10

No disorders were found for HDAC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDAC10 Gene

Publications for HDAC10 Gene

  1. Molecular cloning and characterization of a novel histone deacetylase HDAC10. (PMID: 11726666) Guardiola A.R. … Yao T.-P. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. (PMID: 11677242) Kao H.-Y. … Evans R.M. (J. Biol. Chem. 2002) 2 3 23
  3. Histone deacetylase 10 relieves repression on the melanogenic program by maintaining the deacetylation status of repressors. (PMID: 20032463) Lai I.L. … Yang W.M. (J. Biol. Chem. 2010) 3 23
  4. Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. (PMID: 17172643) Shimazu T. … Yoshida M. (J. Biol. Chem. 2007) 3 23
  5. Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. (PMID: 11861901) Tong J.J. … Yang X.-J. (Nucleic Acids Res. 2002) 3 23

Products for HDAC10 Gene

Sources for HDAC10 Gene

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