HCST Gene
protein-coding GIFtS: 52
GCID: GC19P036393
|
|
hematopoietic cell signal transducer(Previous name: phosphoinositide-3-kinase adaptor protein )
(Previous symbol: PIK3AP)
| |
Aliases
for HCST gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hematopoietic Cell Signal Transducer1 2 | | Transmembrane Adapter Protein KAP102 3 | | DAP101 2 3 5 | | DNAX-Activation Protein 102 3 | | KAP101 2 3 | | DKFZP586C15221 | | PIK3AP1 2 3 | | Kinase Assoc Pro Of ~10kDa2 | | Phosphoinositide-3-Kinase Adaptor Protein1 2 | | Kinase Assoc Protein2 | | Membrane Protein DAP102 3 | | |
Export aliases for HCST gene to outside databasesPrevious GC identifers: GC00U912965 GC19P041085 GC19P032898 |
Summaries
for HCST gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HCST:
This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encodedprotein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As partof this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways throughits intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation byactivation of NK and T cell responses. Alternative splicing results in two transcript variants encoding differentisoforms. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: HCST_HUMAN, Q9UBK5Function: Transmembrane adapter protein which associates with NKG2D to form an activation receptor NKG2D-HCST inlymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cellsexpressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs);these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumortransformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with NKG2D-DAP10triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1and GRB2 are required for full NKG2D-HCST-mediated activation and ultimate killing of target cells. In NK cells,NKG2D-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated viaDAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. NKG2D-HCSTreceptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed,melanoma cells that do not express NKG2D ligands escape from immune surveillance mediated by NK cells
Gene Wiki entry for HCST
|
Genomic Views
for HCST gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HCST gene promoter:
AML1a Tal-1 HSF1 (long) Gfi-1 C/EBPalpha E47 c-Ets-1 SEF-1 (1) HSF1short Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for HCST
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HCST |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.1HCST Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P036393: view genomic region
(about GC identifiers)
Start:
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36,393,382 bp from pter |
End:
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36,395,279 bp from pter |
Size:
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1,898 bases |
Orientation:
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plus strand |
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Proteins
for HCST gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HCST_HUMAN, Q9UBK5 (See
protein sequence)Recommended Name: Hematopoietic cell signal transducer precursor Size: 93 amino acids; 9489 Da
Subunit: Interacts with CLEC5A (By similarity). Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almostsolely on TYROBP (By similarity). Homodimer; Disulfide-linked. Interacts with NKG2D to form a stable complex, whichresults in surface expression of both proteins, whereas alone, it is minimally expressed. Interacts with PIK3R1 andGRB2
Subcellular location: Membrane; Single-pass type I membrane protein
Miscellaneous: Silencing of HCST suppresses cytolytic activity of T-cells and NK cells
Secondary accessions: Q9UBS1 Q9Y3Y0Alternative splicing: 2 isoforms: Q9UBK5-1 Q9UBK5-2 Explore the universe of human proteins at neXtProt for HCST: NX_Q9UBK5
Post-translational modifications:
Phosphorylated; PIK3R1 and GRB2 associate specifically with tyrosine-phosphorylated HCST1
O-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBK5
HCST Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001007470.1 NP_055081.1
ENSEMBL proteins: ENSP00000246551 ENSP00000400516 Reactome Protein details: Q9UBK5
Human Recombinant Protein Products for HCST:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
HCST for ontologies About GeneDecksing
HCST Antibody Products:
Assay Products for HCST: |
Protein
Domains /
Families
for HCST gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HCST for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UBK5ProtoNet protein and cluster: Q9UBK5 UniProtKB/Swiss-Prot: HCST_HUMAN, Q9UBK5Similarity: Belongs to the DAP10 family |
Function
for HCST gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: HCST_HUMAN, Q9UBK5Function: Transmembrane adapter protein which associates with NKG2D to form an activation receptor NKG2D-HCST inlymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cellsexpressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs);these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumortransformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with NKG2D-DAP10triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1and GRB2 are required for full NKG2D-HCST-mediated activation and ultimate killing of target cells. In NK cells,NKG2D-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated viaDAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. NKG2D-HCSTreceptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed,melanoma cells that do not express NKG2D ligands escape from immune surveillance mediated by NK cellsInduction: By T-cell receptor (TCR) ligation, which leads to enhanced NKG2D-HCST cell surface expression.Down-regulated by IL21/interleukin-21 in T-cells and NK cells Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
HCST for ontologies About GeneDecksing
Phenotypes:
10 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Hcst):
HCST for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for HCST: Hcst/TyrobpHcst/tm1Ttk Hcsttm1.1Cln Hcsttm1.1Dnax Hcsttm1Cln
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HCST (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HCST (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): HCST (NM_014266) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HCST | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCST |
|
Pathways & Interactions
for HCST gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | Natural killer cell mediated cytotoxicity | | | 3 | Cleavage of Alpha-1-Microglobulin | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for HCST
1 
Kegg Pathway (Kegg details for HCST):
HCST for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HCST
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/19 Interacting proteins for HCST (Q9UBK53 ENSP000002465514) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0050776 | regulation of immune response |
TAS | -- |
HCST for ontologies About GeneDecksing
|
Drugs & Compounds
for HCST gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HCST for compounds About GeneDecksing
 Browse Tocris compounds for HCST
1 HMDB Compound for HCST About this table
2 Novoseek chemical compound relationships for HCST gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| phosphatidylinositol |
50.2 |
3 |
15048706 (1), 12591902 (1) |
| lysine |
35.1 |
1 |
17483134 (1) |
Search CenterWatch for drugs/clinical trials and news about HCST
|
Transcripts
for HCST gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HCST gene (2 alternative transcripts): NM_001007469.1 NM_014266.3 Unigene Cluster for HCST: Hematopoietic cell signal transducer Hs.117339 [show with all ESTs]Unigene Representative Sequence: CD0494972 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000246551(uc002ocl.1) ENST00000437550(uc002ock.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HCST (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HCST (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): HCST (NM_014266) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HCST | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCST |
Additional cDNA sequence: AF072844.1 AF122904.1 AF172929.1 AF285447.1 AL050163.1 AY359058.1 BC035931.1 BC046348.1 BC065224.1 5 DOTS entries: DT.310625 DT.92417866 DT.95239707 DT.121425007 DT.92326850 24/39 AceView cDNA sequences (see all 39): AI148117 AJ714110 AI357959 NM_014266 BC065224 BP431547 BC035931 AI308984 AA903621 AA937996 AL050163 AA894359 BI753833 AF072844 AA699808 AI141733 AJ713188 BC046348 AI582746 AF285447 AY359058 AA973777 AA829607 AA309780
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for HCST About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | |
ECgene alternative splicing isoforms for HCST
|
Expression
for HCST gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HCST expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGGCAGGG
About this image
See HCST Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HCST
SOURCE GeneReport for Unigene cluster: Hs.117339
UniProtKB/Swiss-Prot: HCST_HUMAN, Q9UBK5Tissue specificity: Predominantly expressed in hemopoietic cells such as NK cells, subset of T-cells and monocytes.Detected in leukocytes, spleen, and thymus
SABiosciences Custom PCR Arrays for HCST
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HCST
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HCST | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HCST | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HCST |
Orthologs
for HCST gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for HCST gene from 1/5 species (see all 5) About this table
ENSEMBL Gene Tree for HCST (if available)
TreeFam Gene Tree for HCST (if available) |
Paralogs
for HCST gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HCST gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HCST (36393382 - 36395279 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HCST
1 CNV: 5097 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HCST |
|
Disorders
/ Diseases
for HCST gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HCST for disorders About GeneDecksing
OMIM gene information: 604089
OMIM disorders: --
6  diseases for HCST: About MalaCardslarge granular lymphocyte leukemia lymphocytic leukemia crohn's disease leukemia
tuberculosis melanoma
Human Genome Epidemiology (HuGE) Navigator: HCST (1 document)
Export disorders for HCST gene to outside databases
|
Publications
for HCST gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HCST gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with HCST) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An activating immunoreceptor complex formed by NKG2D and DAP10. (PubMed id 10426994)1, 2, 3 Wu J....Phillips J.H. (1999)
- Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D. (PubMed id 11398969)1, 2, 9 Yim D.... Kim Y.B. (2001)
- DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells. (PubMed id 11015446)1, 2, 9 Wu J....Lanier L.L. (2000)
- Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells. (PubMed id 16339517)1, 2 Karimi M....Negrin R.S. (2005)
- NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk- independent regulatory pathway. (PubMed id 12740575)1, 2 Billadeau D.D.... Leibson P.J. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. (PubMed id 10528161)1, 2 Chang C.... Wilson M.J. (1999)
- Regulation of human DAP10 gene expression in NK and T cells by Ap-1 transcription factors. (PubMed id 18097042)2, 9 Marusina A.I....Coligan J.E. (2008)
- A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia. (PubMed id 19075187)1, 9 Chen X....Wei S. (2009)
- NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. (PubMed id 16582911)2, 9 Upshaw J.L....Leibson P.J. (2006)
|
External Searches for HCST gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HCST gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HCST gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HCST gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HCST | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HCST gene:
Search GeneIP for patents involving HCST
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HCST gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for HCST | | OriGene shRNA RFP for HCST | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HCST | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HCST | | | OriGene Protein Over-expression Lysate for HCST | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HCST | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HCST | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HCST | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HCST | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HCST | | OriGene Custom Protein Services for HCST | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HCST | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HCST | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HCST | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HCST | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HCST | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HCST |
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| | | |  |  |  |  | | | | ThermoFisher Antibodies for HCST |
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