HCRTR2 Gene
protein-coding GIFtS: 63
GCID: GC06P055085
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hypocretin (orexin) receptor 2
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Aliases
for HCRTR2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hypocretin (Orexin) Receptor 21 2 | | Ox2-R3 | | OX2R1 2 | | Ox-2-R3 | | Hypocretin Receptor Type 22 3 | | Ox2-R3 | | Orexin Receptor Type 22 | | Ox2R3 | | Ox-2-R3 | | |
Export aliases for HCRTR2 gene to outside databasesPrevious GC identifers: GC06P055041 GC06P055147 GC06P054873 |
Summaries
for HCRTR2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HCRTR2:
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. Theencoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes aG-protein coupled receptor that selectively binds orexin A. (provided by RefSeq, Jan 2009)
UniProtKB/Swiss-Prot: OX2R_HUMAN, O43614Function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides
 summary
for HCRTR2: The OX2 receptors, also known as hypocretin receptor 2, are located primarily in the cerebral cortex,
paraventricular hypothalamus, nucleus accumbens, subthalamic and paraventricular thalamus where they are
thought to regulate sleep-wakefulness. The OX2 receptor displays equal affinity for Orexin A and Orexin B.
The human OX2 receptor gene has been localized to chromosome 6 (6p11-q11).
Gene Wiki entry for HCRTR2 (Hypocretin receptor 2)
|
Genomic Views
for HCRTR2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HCRTR2 gene promoter:
SRF HFH-3 MEF-2 SRF (504 AA) FOXI1 SRY SEF-1 (1) c-Myb Cart-1 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HCRTR2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HCRTR2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p12 Ensembl cytogenetic band: 6p12.1 HGNC cytogenetic band: 6p12.1HCRTR2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P055085: view genomic region
(about GC identifiers)
Start:
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55,039,050 bp from pter |
End:
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55,147,418 bp from pter |
Size:
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108,369 bases |
Orientation:
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plus strand |
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Proteins
for HCRTR2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OX2R_HUMAN, O43614 (See
protein sequence)Recommended Name: Orexin receptor type 2 Size: 444 amino acids; 50694 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q5VTM0Explore the universe of human proteins at neXtProt for HCRTR2: NX_O43614
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43614
HCRTR2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001517.2
ENSEMBL proteins: ENSP00000359899 Reactome Protein details: O43614
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HCRTR2 for ontologies About GeneDecksing
HCRTR2 Antibody Products:
Assay Products for HCRTR2: |
Protein
Domains /
Families
for HCRTR2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HCRTR2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43614ProtoNet protein and cluster: O43614 1 Blocks protein family: IPB000204 Orexin receptor signature
UniProtKB/Swiss-Prot: OX2R_HUMAN, O43614Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for HCRTR2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OX2R_HUMAN, O43614Function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides Genatlas biochemistry entry for HCRTR2:hypocretin receptor 2,G protein coupled receptor superfamily binding both HCRT isoforms A and B
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HCRTR2
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCRTR2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
HCRTR2 for ontologies About GeneDecksing
Animal Models:
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Hcrtr2):
HCRTR2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HCRTR2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | G alpha (q) signalling events | | | 4 | Orexin and neuropeptides FF and QRFP bind to their respective receptors | | | 5 | Adenylate cyclase-activating neuropeptides | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for HCRTR2
1  BioSystems Pathway for HCRTR2
5/9 
Reactome Pathways for HCRTR2 (see all 9)
1 
Kegg Pathway (Kegg details for HCRTR2):
HCRTR2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HCRTR2
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for HCRTR2 (O436143 ENSP000003598994) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
HCRTR2 for ontologies About GeneDecksing
|
Drugs & Compounds
for HCRTR2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HCRTR2 for compounds About GeneDecksing
Compounds for HCRTR2 available from Tocris Bioscience About this table
8 Novoseek chemical compound relationships for HCRTR2 gene About this table
Search CenterWatch for drugs/clinical trials and news about HCRTR2 / OX2R
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Transcripts
for HCRTR2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HCRTR2 gene: NM_001526.3 Unigene Clusters for HCRTR2: Hypocretin (orexin) receptor 2 Hs.151624 [show with all ESTs], Hs.699147 [show with all ESTs]Unigene Representative Sequences: AF041245, EF6331101 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000370862(uc003pcl.3 uc010jzv.3 uc010jzw.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HCRTR2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HCRTR2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HCRTR2 (NM_001526) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HCRTR2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCRTR2 |
Additional cDNA sequence: EF633107.1 EF633108.1 EF633109.1 EF633110.1 2 DOTS entries: DT.406703 DT.92021265 11 AceView cDNA sequences: BU680891 BM926746 NM_001526 BX109847 W86471 BC035858 AF041245 D81887 CF147829 W86548 BG204832
GeneLoc Exon Structure
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Expression
for HCRTR2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HCRTR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCAGGCGG
About this image
See HCRTR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HCRTR2
SOURCE GeneReport for Unigene clusters: Hs.151624 Hs.699147
SABiosciences Expression via Pathway-Focused PCR Arrays including HCRTR2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HCRTR2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCRTR2 |
Orthologs
for HCRTR2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HCRTR2 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for HCRTR2 (if available)
TreeFam Gene Tree for HCRTR2 (if available) |
Paralogs
for HCRTR2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HCRTR2 gene
- GPR832 PRLHR2 NPFFR22 PPYR12 NPY5R2 TACR12 TACR32 NPY1R2
- QRFPR2 NPFFR12 NPY2R2 HCRTR12 TACR22
5 SIMAP similar genes for HCRTR2 using alignment to 2 protein entries: OX2R_HUMAN (see all proteins):HCRTR1 DRD3 NPFFR2 PRLHR NPY2R
HCRTR2 for paralogs About GeneDecksing
|
Genomic Variants
for HCRTR2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HCRTR2 (55039050 - 55147418 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HCRTR2: --
Human Gene Mutation Database (HGMD): HCRTR2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HCRTR2 |
|
Disorders
/ Diseases
for HCRTR2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HCRTR2 for disorders About GeneDecksing
OMIM gene information: 602393
OMIM disorders: --
20/26  diseases for HCRTR2 (see all 26): About MalaCardscluster headache cerebritis myotonic dystrophy type 1 myotonic dystrophy
autism spectrum disorder infectious mononucleosis sleep apnea headache
anorexia nervosa panic disorder apnea tourette syndrome
mood disorder sleep disorder narcolepsy gliosis
pheochromocytoma albinism obesity migraine
1 disease from the University of Copenhagen DISEASES database for HCRTR2:Sleep disorder 5 Novoseek disease relationships for HCRTR2 gene About this table
Genetic Association Database (GAD): HCRTR2
Human Genome Epidemiology (HuGE) Navigator: HCRTR2 (18 documents)
Export disorders for HCRTR2 gene to outside databases
|
Publications
for HCRTR2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HCRTR2 gene, integrated from 9 sources (see all 104):
(articles sorted by number of sources associating them with HCRTR2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. (PubMed id 9491897)1, 2, 3 Sakurai T....Yanagisawa M. (1998)
- Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. (PubMed id 15978554)1, 4, 9 Meerabux J....Yoshikawa T. (2005)
- Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity. (PubMed id 15274044)1, 4, 9 Thompson M.D....Moldofsky H. (2004)
- A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache. (PubMed id 15477554)1, 4, 9 Rainero I....Pinessi L. (2004)
- Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. (PubMed id 11723285)1, 2, 9 Olafsdottir B.R.... Gulcher J.R. (2001)
- Hypocretin/orexin, sleep and narcolepsy. (PubMed id 11340621)1, 2, 9 Hungs M. and Mignot E. (2001)
- To eat or to sleep? Orexin in the regulation of feeding and wakefulness. (PubMed id 11283317)1, 2 Willie J.T.... Yanagisawa M. (2001)
- Haplotype Analysis Confirms the Association Between the HCRTR2 Gene and Cluster Headache. (PubMed id 18399985)1, 9 Rainero I....Pinessi L. (2008)
- The signalling profile of recombinant human orexin-2 receptor. (PubMed id 18599270)1, 9 Tang J....Randeva H.S. (2008)
- Cellular localization of orexin receptors in human pituitary. (PubMed id 11443222)1, 9 Blanco M....Beiras A. (2001)
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External Searches for HCRTR2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HCRTR2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HCRTR2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HCRTR2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HCRTR2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HCRTR2 gene:
Search GeneIP for patents involving HCRTR2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HCRTR2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HCRTR2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HCRTR2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HCRTR2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HCRTR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HCRTR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HCRTR2 |
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 | | | HCRTR2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCRTR2 |
|  |  |  | | | | ThermoFisher Antibodies for HCRTR2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCRTR2 |
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