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Aliases for HCRTR2 Gene

Aliases for HCRTR2 Gene

  • Hypocretin Receptor 2 2 3
  • Hypocretin (Orexin) Receptor 2 2 3 5
  • Hypocretin Receptor Type 2 3 4
  • Ox-2-R 3 4
  • Ox2-R 3 4
  • OX2R 3 4
  • Orexin Type-2 Receptor 3
  • Orexin Receptor 2 2

External Ids for HCRTR2 Gene

Previous GeneCards Identifiers for HCRTR2 Gene

  • GC06P055041
  • GC06P055085
  • GC06P055147
  • GC06P054873

Summaries for HCRTR2 Gene

Entrez Gene Summary for HCRTR2 Gene

  • The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

GeneCards Summary for HCRTR2 Gene

HCRTR2 (Hypocretin Receptor 2) is a Protein Coding gene. Diseases associated with HCRTR2 include Cluster Headache and Narcolepsy. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and peptide hormone binding. An important paralog of this gene is NPY1R.

UniProtKB/Swiss-Prot for HCRTR2 Gene

  • Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.

Tocris Summary for HCRTR2 Gene

  • The OX2 receptors, also known as hypocretin receptor 2, are located primarily in the cerebral cortex, paraventricular hypothalamus, nucleus accumbens, subthalamic and paraventricular thalamus where they are thought to regulate sleep-wakefulness.

Gene Wiki entry for HCRTR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCRTR2 Gene

Genomics for HCRTR2 Gene

Regulatory Elements for HCRTR2 Gene

Enhancers for HCRTR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HCRTR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HCRTR2 Gene

55,106,460 bp from pter
55,282,620 bp from pter
176,161 bases
Plus strand

Genomic View for HCRTR2 Gene

Genes around HCRTR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCRTR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCRTR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCRTR2 Gene

Proteins for HCRTR2 Gene

  • Protein details for HCRTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Orexin receptor type 2
    Protein Accession:
    Secondary Accessions:
    • Q5VTM0

    Protein attributes for HCRTR2 Gene

    444 amino acids
    Molecular mass:
    50694 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HCRTR2 Gene

neXtProt entry for HCRTR2 Gene

Proteomics data for HCRTR2 Gene at MOPED

Post-translational modifications for HCRTR2 Gene

  • Glycosylation at Asn 14, Asn 22, and Asn 202
  • Modification sites at PhosphoSitePlus

Other Protein References for HCRTR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HCRTR2 (Orexin R2/HCRTR2)

No data available for DME Specific Peptides for HCRTR2 Gene

Domains & Families for HCRTR2 Gene

Gene Families for HCRTR2 Gene

Protein Domains for HCRTR2 Gene

Suggested Antigen Peptide Sequences for HCRTR2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HCRTR2: view

Function for HCRTR2 Gene

Molecular function for HCRTR2 Gene

GENATLAS Biochemistry:
hypocretin receptor 2,G protein coupled receptor superfamily binding both HCRT isoforms A and B
UniProtKB/Swiss-Prot Function:
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.
genes like me logo Genes that share phenotypes with HCRTR2: view

Animal Models for HCRTR2 Gene

MGI Knock Outs for HCRTR2:

Animal Model Products

miRNA for HCRTR2 Gene

miRTarBase miRNAs that target HCRTR2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HCRTR2 Gene

Localization for HCRTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCRTR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for HCRTR2 Gene COMPARTMENTS Subcellular localization image for HCRTR2 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for HCRTR2 Gene

Pathways & Interactions for HCRTR2 Gene

genes like me logo Genes that share pathways with HCRTR2: view

SIGNOR curated interactions for HCRTR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HCRTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0022410 circadian sleep/wake cycle process IEA --
GO:0032870 cellular response to hormone stimulus IBA --
GO:0045187 regulation of circadian sleep/wake cycle, sleep IBA --
genes like me logo Genes that share ontologies with HCRTR2: view

Drugs & Compounds for HCRTR2 Gene

(25) Drugs for HCRTR2 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Suvorexant Approved Pharma Antagonist 18
Allopurinol Approved Pharma 132
SB-649868 Experimental Pharma Antagonist, antagonist 0
EMPA Pharma Highly potent and selective OX2 antagonist; brain penetrant 0
JNJ 10397049 Pharma Selective OX2 receptor antagonist 0

(8) Additional Compounds for HCRTR2 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Ala11,D-Leu15]-Orexin B

(4) Tocris Compounds for HCRTR2 Gene

Compound Action Cas Number
[Ala11,D-Leu15]-Orexin B Potent, selective OX2 receptor agonist 532932-99-3
EMPA Highly potent and selective OX2 antagonist; brain penetrant 680590-49-2
JNJ 10397049 Selective OX2 receptor antagonist 708275-58-5
TCS OX2 29 Potent and selective OX2 antagonist 372523-75-6

(5) ApexBio Compounds for HCRTR2 Gene

Compound Action Cas Number
Allopurinol 315-30-0
Almorexant hydrochloride OX1R/OX2R antagonist 913358-93-7
MK-4305 OX1/OX2 atagonist,potent and selective 1030377-33-3
SB-334867 free base 792173-99-0
SB408124 OX(1)receptor antagonist 288150-92-5
genes like me logo Genes that share compounds with HCRTR2: view

Transcripts for HCRTR2 Gene

mRNA/cDNA for HCRTR2 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HCRTR2 Gene

Hypocretin (orexin) receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HCRTR2 Gene

No ASD Table

Relevant External Links for HCRTR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HCRTR2 Gene

mRNA expression in normal human tissues for HCRTR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HCRTR2 Gene

This gene is overexpressed in Brain - Hypothalamus (x9.4), Brain - Substantia nigra (x5.6), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HCRTR2 Gene

SOURCE GeneReport for Unigene cluster for HCRTR2 Gene Hs.151624

genes like me logo Genes that share expression patterns with HCRTR2: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HCRTR2 Gene

Orthologs for HCRTR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HCRTR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HCRTR2 35
  • 89.86 (n)
  • 96.85 (a)
  • 97 (a)
(Canis familiaris)
Mammalia HCRTR2 35
  • 93.09 (n)
  • 97.75 (a)
  • 98 (a)
(Mus musculus)
Mammalia Hcrtr2 35
  • 87.96 (n)
  • 94.58 (a)
Hcrtr2 16
Hcrtr2 36
  • 91 (a)
(Pan troglodytes)
Mammalia HCRTR2 35
  • 99.55 (n)
  • 99.1 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Hcrtr2 35
  • 88.04 (n)
  • 94.58 (a)
(Monodelphis domestica)
Mammalia HCRTR2 36
  • 84 (a)
(Gallus gallus)
Aves HCRTR2 35
  • 80.2 (n)
  • 86.93 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia HCRTR2 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hcrtr2 35
  • 75.09 (n)
  • 84.05 (a)
(Danio rerio)
Actinopterygii hcrtr2 35
  • 68.88 (n)
  • 71.56 (a)
hcrtr2 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta NepYr 37
  • 31 (a)
  • 17 (a)
(Caenorhabditis elegans)
Secernentea npr-2 35
  • 42.7 (n)
  • 29.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for HCRTR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HCRTR2 Gene

Gene Tree for HCRTR2 (if available)
Gene Tree for HCRTR2 (if available)

Paralogs for HCRTR2 Gene

(16) SIMAP similar genes for HCRTR2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HCRTR2: view

Variants for HCRTR2 Gene

Sequence variations from dbSNP and Humsavar for HCRTR2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs41271310 - 55,174,615(+) ACTCC(C/T)CCCCT reference, missense
rs41271312 - 55,174,618(+) CCCCC(A/C/G)CTTGT reference, missense
VAR_044509 -
rs2653349 - 55,277,539(+) TGATG(A/G/T)TTGTG reference, missense
rs1013624 -- 55,269,804(-) ttttt(A/G)tgttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HCRTR2 Gene

Variant ID Type Subtype PubMed ID
dgv6849n71 CNV Gain 21882294

Variation tolerance for HCRTR2 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HCRTR2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCRTR2 Gene

Disorders for HCRTR2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for HCRTR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cluster headache
  • narcolepsy, without cataplexy
sleep disorder
  • non-organic sleep disorder
hallucinogen dependence
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HCRTR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HCRTR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HCRTR2 Gene

Publications for HCRTR2 Gene

  1. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. (PMID: 9491897) Sakurai T. … Yanagisawa M. (Cell 1998) 2 3 4 67
  2. Genomic organization and regulation of the human orexin (hypocretin) receptor 2 gene: identification of alternative promoters. (PMID: 20156195) Chen J. … Randeva H.S. (Biochem. J. 2010) 3 23
  3. Haplotype analysis confirms the association between the HCRTR2 gene and cluster headache. (PMID: 18399985) Rainero I. … Pinessi L. (Headache 2008) 3 23
  4. The signalling profile of recombinant human orexin-2 receptor. (PMID: 18599270) Tang J. … Randeva H.S. (Cell. Signal. 2008) 3 23
  5. Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy. (PMID: 18714784) Mishima K. … Nishino S. (Sleep 2008) 3 23

Products for HCRTR2 Gene

Sources for HCRTR2 Gene