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HCRTR2 Gene

protein-coding   GIFtS: 65
GCID: GC06P055085

Hypocretin (Orexin) Receptor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hypocretin (Orexin) Receptor 21 2     ox-2-R2
Hypocretin Receptor Type 22 3     ox2-R2
OX2R2     Ox-2-R3
Orexin Receptor Type 22     Ox2-R3
Orexin Type-2 Receptor2     Ox2R3

External Ids:    HGNC: 48491   Entrez Gene: 30622   Ensembl: ENSG000001372527   OMIM: 6023935   UniProtKB: O436143   

Export aliases for HCRTR2 gene to outside databases

Previous GC identifers: GC06P055041 GC06P055147 GC06P054873


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HCRTR2 Gene:
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior.
The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a
G-protein coupled receptor that selectively binds orexin A. (provided by RefSeq, Jan 2009)

GeneCards Summary for HCRTR2 Gene:
HCRTR2 (hypocretin (orexin) receptor 2) is a protein-coding gene. Diseases associated with HCRTR2 include cluster headache, and headache. GO annotations related to this gene include orexin receptor activity and peptide hormone binding. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: OX2R_HUMAN, O43614
Function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides

summary for HCRTR2 Gene:
The OX2 receptors, also known as hypocretin receptor 2, are located primarily in the cerebral cortex,
paraventricular hypothalamus, nucleus accumbens, subthalamic and paraventricular thalamus where they are
thought to regulate sleep-wakefulness. The OX2 receptor displays equal affinity for Orexin A and Orexin B.
The human OX2 receptor gene has been localized to chromosome 6 (6p11-q11).

Gene Wiki entry for HCRTR2 (Hypocretin receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HCRTR2 gene promoter:
         SRF   HFH-3   MEF-2   SRF (504 AA)   FOXI1   SRY   SEF-1 (1)   c-Myb   Cart-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHCRTR2 promoter sequence
   Search Chromatin IP Primers for HCRTR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HCRTR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12   Ensembl cytogenetic band:  6p12.1   HGNC cytogenetic band: 6p12.1

HCRTR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HCRTR2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P055085:  view genomic region     (about GC identifiers)

Start:
55,039,050 bp from pter      End:
55,147,418 bp from pter
Size:
108,369 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OX2R_HUMAN, O43614 (See protein sequence)
Recommended Name: Orexin receptor type 2  
Size: 444 amino acids; 50694 Da
Secondary accessions: Q5VTM0

Explore the universe of human proteins at neXtProt for HCRTR2: NX_O43614

Explore proteomics data for HCRTR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn14, Asn22, Asn202

  • See HCRTR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001517.2  
    ENSEMBL proteins: 
     ENSP00000359899  
    Reactome Protein details: O43614

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HCRTR: GPCR / Class A : Hypocretin (orexin) receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: OX2 receptor
    Orexin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004060 Orexin_rcpt_2
     IPR000204 Orexin_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O43614

    ProtoNet protein and cluster: O43614

    1 Blocks protein domain: IPB000204 Orexin receptor signature

    UniProtKB/Swiss-Prot: OX2R_HUMAN, O43614
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HCRTR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OX2R_HUMAN, O43614
    Function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides

         Genatlas biochemistry entry for HCRTR2:
    hypocretin receptor 2,G protein coupled receptor superfamily binding both HCRT isoforms A and B

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0008188neuropeptide receptor activity TAS9491897
    GO:0016499orexin receptor activity IEA--
    GO:0017046peptide hormone binding IEA--
         
    HCRTR2 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hcrtr2):
     behavior/neurological  muscle  nervous system 

    HCRTR2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HCRTR2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HCRTR2
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    miRNA
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    1 qRT-PCR Assays for microRNA that regulate HCRTR2:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidHCRTR2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OX2R_HUMAN, O43614: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9491897
    GO:0016021integral component of membrane ----

    HCRTR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HCRTR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    Orexin and neuropeptides FF and QRFP bind to their respective receptors0.00
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    5Adenylate cyclase activating neuropeptides
    Adenylate cyclase activating neuropeptides

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HCRTR2
        GPCRs, Class A Rhodopsin-like


    2 Reactome Pathways for HCRTR2
        Orexin and neuropeptides FF and QRFP bind to their respective receptors
    G alpha (q) signalling events


    1 Kegg Pathway  (Kegg details for HCRTR2):
        Neuroactive ligand-receptor interaction


    HCRTR2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HCRTR2: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HCRTR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for HCRTR2 (O436143 ENSP000003598994) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD200P412173, ENSP000004202984I2D: score=2 STRING: ENSP00000420298
    HCRTO436123, ENSP000002933304I2D: score=2 STRING: ENSP00000293330
    NMUENSP000002642184STRING: ENSP00000264218
    NMSENSP000003660614STRING: ENSP00000366061
    MX1ENSP000003815994STRING: ENSP00000381599
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007218neuropeptide signaling pathway TAS9491897
    GO:0007268synaptic transmission TAS9491897
    GO:0007631feeding behavior IEA--

    HCRTR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HCRTR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [Ala11,D-Leu15]-Orexin B Potent, selective OX2 receptor agonist [532932-99-3]
    EMPAHighly potent and selective OX2 antagonist; brain penetrant[680590-49-2]
    TCS OX2 29Potent and selective OX2 antagonist[372523-75-6]
    JNJ 10397049Selective OX2 receptor antagonist[708275-58-5]

    Selected IUPHAR Ligands for HCRTR2 (OX2 receptor) (see all 14)    About this table
    LigandTypeActionAffinityPubmed IDs
    orexin-B
    AgonistFull agonist6.5 - 1012702704 18599270 9491897 12208495 11162621
    orexin-A
    AgonistFull agonist6.5 - 1012702704 18599270 9491897 12208495 11162621
    [Ala11, D-Leu15]orexin-B
    AgonistFull agonist9.912467628
    MK-6096
    AntagonistAntagonist9.522019562
    suvorexant
    AntagonistAntagonist9.4620565075
    N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulphonyl)-amino]-N-pyridin-3-ylmethyl-acetamide
    AntagonistAntagonist919751316
    SB-649868
    AntagonistAntagonist8.921831639
    1-(2,4-dibromo-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea
    AntagonistAntagonist7.9 - 8.615261275
    ACT-078573
    AntagonistAntagonist8.117259994
    TCS-OX2-29
    AntagonistAntagonist7.414643355

    8 Novoseek inferred chemical compound relationships for HCRTR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acth 27.4 2 11443222 (1), 11297593 (1)
    ribonucleic acid 22.3 2 11158046 (1)
    calcium 16.2 2 14691055 (1), 18815029 (1)
    acetylcholine 14.8 3 16352704 (2)
    catecholamine 7.45 1 11600547 (1)
    alanine 3.27 1 12467628 (1)
    histamine 0 1 11682143 (1)
    norepinephrine 0 2 11830291 (2)



    HCRTR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HCRTR2 gene: 
    NM_001526.3  

    Unigene Cluster for HCRTR2:

    Hypocretin (orexin) receptor 2
    Hs.151624  [show with all ESTs]
    Unigene Representative Sequence: AF041245
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000370862(uc003pcl.3 uc010jzv.3 uc010jzw.1)
    miRNA
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    Additional mRNA sequence: 

    AF041245.1 AK307819.1 AK314279.1 BC035858.1 

    2 DOTS entries:

    DT.406703  DT.92021265 

    11 AceView cDNA sequences:

    BM926746 BU680891 BX109847 BC035858 NM_001526 D81887 AF041245 W86471 
    CF147829 W86548 BG204832 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HCRTR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCAGGCGG
    HCRTR2 Expression
    About this image


    HCRTR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 7
    HCRTR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HCRTR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.151624
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HCRTR2: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HCRTR2
    OriGene qSTAR qPCR primer pairs in human, mouse for HCRTR2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCRTR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HCRTR2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hcrtr21 , 5 hypocretin (orexin) receptor 21, 5 87.96(n)1
    94.58(a)1
      9 (42.48 cM)5
    3872851  NM_198962.31  NP_945200.11 
     762258805 
    chicken
    (Gallus gallus)
    Aves HCRTR21 hypocretin (orexin) receptor 2 80.2(n)
    86.93(a)
      428644  NM_001024584.1  NP_001019755.1 
    lizard
    (Anolis carolinensis)
    Reptilia HCRTR26
    hypocretin (orexin) receptor 2
    81(a)
    1 ↔ 1
    GL343342.1(485979-517327)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hcrtr21 hypocretin (orexin) receptor 2 75.09(n)
    84.05(a)
      100495420  XM_002934850.2  XP_002934896.2 
    zebrafish
    (Danio rerio)
    Actinopterygii hcrtr21 hypocretin (orexin) receptor 2 68.88(n)
    71.56(a)
      561260  NM_001079868.1  NP_001073337.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NepYr3 G-protein coupled receptor protein
    signaling pathway more
    31(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea npr-21 npr-2 42.7(n)
    29.43(a)
      177790  NM_069300.4  NP_501701.2 


    ENSEMBL Gene Tree for HCRTR2 (if available)
    TreeFam Gene Tree for HCRTR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HCRTR2 gene
    GPR832  PRLHR2  NPFFR22  NPY5R2  NPY4R2  TACR12  TACR32  NPY1R2  
    NPY2R2  NPFFR12  QRFPR2  HCRTR12  TACR22  
    16 SIMAP similar genes for HCRTR2 using alignment to 4 protein entries:     OX2R_HUMAN (see all proteins):
    HCRTR1    DRD3    CCKBR    ADORA2A    CXCR2    DRD2
    GIR    QRFPR    TACR1    hA2aR    FPR2    GPR85
    GPR18    CHRM1    NPFFR2    PRLHR

    HCRTR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HCRTR2 (see all 2516)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1996485601,2
    --54899872(+) GTGTG-/TTTTTGA 1 -- int10--------
    rs1418413231,2
    C--54924048(+) CCACT-/ATAAAA 1 -- int10--------
    rs1125070381,2
    C--54924222(+) CAGTT-/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1995890171,2
    C--54930440(+) AAAGA-/TTTTTTT 1 -- int10--------
    rs766833511,2
    C--54941983(+) GGGGGA/GAAAAA 1 -- int10--------
    rs94642031,2
    C,F,H--54942310(+) GTTTGG/ATTTGC 1 -- us2k1 tfbs320Minor allele frequency- A:0.10NS EA NA WA 2340
    rs93824601,2
    C,F,H--54942670(+) TAAATC/AATCTA 1 -- us2k120Minor allele frequency- A:0.20NS EA CSA WA NA 2758
    rs93824611,2
    C,F,H--54942884(+) TACATA/GTAAAA 1 -- us2k18Minor allele frequency- G:0.06NS EA NA CSA WA 661
    rs558666391,2
    C,F--54942951(+) TATTGC/TTACTT 1 -- us2k17Minor allele frequency- T:0.49WA NA CSA EA 365
    rs93824621,2
    C,F,H--54943017(+) AGATGT/AAGGTG 1 -- us2k17Minor allele frequency- A:0.09NS EA NA CSA WA 539

    HapMap Linkage Disequilibrium report for HCRTR2 (55039050 - 55147418 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HCRTR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6849n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): HCRTR2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HCRTR2
    DNA2.0 Custom Variant and Variant Library Synthesis for HCRTR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602393    OMIM disorders: --

    Selected diseases for HCRTR2 (see all 22):    
    About MalaCards
    cluster headache    headache    narcolepsy    myotonic dystrophy type 1
    sleep disorder    cerebritis    myotonic dystrophy    sleep apnea
    panic disorder    pheochromocytoma    albinism    mood disorder
    migraine    autism spectrum disorder    pertussis    anorexia nervosa
    duodenitis    obesity    adenoma    hiv-1

    1 disease from the University of Copenhagen DISEASES database for HCRTR2:
    Sleep disorder

    HCRTR2 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for HCRTR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    narcolepsy 89.6 25 15246829 (2), 14580598 (2), 11282968 (2), 10973318 (1) (see all 14)
    cluster headache 66.6 8 17883525 (1), 15477554 (1), 17376114 (1), 18399985 (1) (see all 6)
    adenoma adrenocortical 49.6 2 11830291 (1)
    pheochromocytoma 13 4 11600547 (2), 11830291 (1)
    obesity 0 1 19489767 (1)

    Genetic Association Database (GAD): HCRTR2
    Human Genome Epidemiology (HuGE) Navigator: HCRTR2 (18 documents)

    Export disorders for HCRTR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HCRTR2 gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with HCRTR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. (PubMed id 9491897)1, 2, 3 Sakurai T....Yanagisawa M. (Cell 1998)
    2. Haplotype analysis confirms the association between the HCRTR2 gene and cluster headache. (PubMed id 18399985)1, 4, 9 Rainero I....Pinessi L. (Headache 2008)
    3. The 1246G--&gt;A polymorphism of the HCRTR2 gene is not associated with migraine. (PubMed id 17645762)1, 4, 9 Pinessi L....Vaula G. (Cephalalgia 2007)
    4. Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis. (PubMed id 17563843)1, 4, 9 Rainero I....Pinessi L. (J Headache Pain 2007)
    5. The G1246A polymorphism in the hypocretin receptor 2 gene is not associated with treatment response in cluster headache. (PubMed id 17376114)1, 4, 9 SchA1rks M....Rosskopf D. (Cephalalgia 2007)
    6. Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene. (PubMed id 16554494)1, 4, 9 SchA1rks M....Rosskopf D. (Neurology 2006)
    7. Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. (PubMed id 15978554)1, 4, 9 Meerabux J....Yoshikawa T. (Biol. Psychiatry 2005)
    8. Association between migraine and the G1246A polymorphism in the hypocretin receptor 2 gene. (PubMed id 17883525)1, 4, 9 SchA1rks M....Rosskopf D. (Headache 2007)
    9. Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity. (PubMed id 15274044)1, 4, 9 Thompson M.D....Moldofsky H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004)
    10. A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache. (PubMed id 15477554)1, 4, 9 Rainero I....Pinessi L. (Neurology 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3062 HGNC: 4849 AceView: HCRTR2 Ensembl:ENSG00000137252 euGenes: HUgn3062
    ECgene: HCRTR2 Kegg: 3062 H-InvDB: HCRTR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HCRTR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HCRTR2 gene:
    Search GeneIP for patents involving HCRTR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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