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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HCRTR2 Gene

protein-coding   GIFtS: 65
GCID: GC06P055085

Hypocretin (Orexin) Receptor 2

Pneumococci & Pneumococcal Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hypocretin (Orexin) Receptor 21 2     ox-2-R2
Hypocretin Receptor Type 22 3     ox2-R2
OX2R2     Ox-2-R3
Orexin Receptor Type 22     Ox2-R3
Orexin Type-2 Receptor2     Ox2R3

External Ids:    HGNC: 48491   Entrez Gene: 30622   Ensembl: ENSG000001372527   OMIM: 6023935   UniProtKB: O436143   

Export aliases for HCRTR2 gene to outside databases

Previous GC identifers: GC06P055041 GC06P055147 GC06P054873


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HCRTR2 Gene:
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior.
The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a
G-protein coupled receptor that selectively binds orexin A. (provided by RefSeq, Jan 2009)

GeneCards Summary for HCRTR2 Gene: 
HCRTR2 (hypocretin (orexin) receptor 2) is a protein-coding gene. Diseases associated with HCRTR2 include cluster headache, and narcolepsy, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include orexin receptor activity and peptide hormone binding. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: OX2R_HUMAN, O43614
Function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides

summary for HCRTR2 Gene:
The OX2 receptors, also known as hypocretin receptor 2, are located primarily in the cerebral cortex,
paraventricular hypothalamus, nucleus accumbens, subthalamic and paraventricular thalamus where they are
thought to regulate sleep-wakefulness. The OX2 receptor displays equal affinity for Orexin A and Orexin B.
The human OX2 receptor gene has been localized to chromosome 6 (6p11-q11).

Gene Wiki entry for HCRTR2 (Hypocretin receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HCRTR2 gene promoter:
         SRF   HFH-3   MEF-2   SRF (504 AA)   FOXI1   SRY   SEF-1 (1)   c-Myb   Cart-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHCRTR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HCRTR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HCRTR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12   Ensembl cytogenetic band:  6p12.1   HGNC cytogenetic band: 6p12.1

HCRTR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HCRTR2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P055085:  view genomic region     (about GC identifiers)

Start:
55,039,050 bp from pter      End:
55,147,418 bp from pter
Size:
108,369 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OX2R_HUMAN, O43614 (See protein sequence)
Recommended Name: Orexin receptor type 2  
Size: 444 amino acids; 50694 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q5VTM0

Explore the universe of human proteins at neXtProt for HCRTR2: NX_O43614

Explore proteomics data for HCRTR2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43614

  • HCRTR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HCRTR2 Protein Expression
    REFSEQ proteins: NP_001517.2  
    ENSEMBL proteins: 
     ENSP00000359899  
    Reactome Protein details: O43614
    Human Recombinant Protein Products for HCRTR2: 
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    Cloud-Clone Corp. Proteins for HCRTR2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9491897
    GO:0016021integral to membrane ----

    HCRTR2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HCRTR: GPCR / Class A : Hypocretin (orexin) receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: OX2 receptor 
    Orexin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004060 Orexin_rcpt_2
     IPR000204 Orexin_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O43614

    ProtoNet protein and cluster: O43614

    1 Blocks protein domain: IPB000204 Orexin receptor signature

    UniProtKB/Swiss-Prot: OX2R_HUMAN, O43614
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HCRTR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OX2R_HUMAN, O43614
    Function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides

         Genatlas biochemistry entry for HCRTR2:
    hypocretin receptor 2,G protein coupled receptor superfamily binding both HCRT isoforms A and B

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0008188neuropeptide receptor activity TAS9491897
    GO:0016499orexin receptor activity IEA--
    GO:0017046peptide hormone binding IEA--
         
    HCRTR2 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hcrtr2):
     behavior/neurological  muscle  nervous system 

    HCRTR2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HCRTR2 
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate HCRTR2:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidHCRTR2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HCRTR2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    5Orexin and neuropeptides FF and QRFP bind to their respective receptors
    Orexin and neuropeptides FF and QRFP bind to their respective receptors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for HCRTR2
        Adenylate cyclase-activating neuropeptides
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    1 BioSystems Pathway for HCRTR2
        GPCRs, Class A Rhodopsin-like


    5/9        Reactome Pathways for HCRTR2 (see all 9)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Orexin and neuropeptides FF and QRFP bind to their respective receptors
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for HCRTR2):
        Neuroactive ligand-receptor interaction


    HCRTR2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HCRTR2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for HCRTR2 (O436143 ENSP000003598994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD200P412173, ENSP000004202984I2D: score=2 STRING: ENSP00000420298
    HCRTO436123, ENSP000002933304I2D: score=2 STRING: ENSP00000293330
    NMSENSP000003660614STRING: ENSP00000366061
    NMUENSP000002642184STRING: ENSP00000264218
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007218neuropeptide signaling pathway TAS9491897
    GO:0007268synaptic transmission TAS9491897
    GO:0007631feeding behavior IEA--

    HCRTR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HCRTR2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HCRTR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [Ala11,D-Leu15]-Orexin B Potent, selective OX2 receptor agonist [532932-99-3]
    EMPAHighly potent and selective OX2 antagonist; brain penetrant[680590-49-2]
    TCS OX2 29Potent and selective OX2 antagonist[372523-75-6]
    JNJ 10397049Selective OX2 receptor antagonist[708275-58-5]

    10/14 IUPHAR Ligands for HCRTR2 (OX2 receptor) (see all 14)    About this table 
    LigandTypeActionAffinityPubmed IDs
    orexin-B
    AgonistFull agonist6.5 - 1012702704 18599270 9491897 12208495 11162621
    orexin-A
    AgonistFull agonist6.5 - 1012702704 18599270 9491897 12208495 11162621
    [Ala11, D-Leu15]orexin-B
    AgonistFull agonist9.912467628
    MK-6096
    AntagonistAntagonist9.522019562
    suvorexant
    AntagonistAntagonist9.4620565075
    N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulphonyl)-amino]-N-pyridin-3-ylmethyl-acetamide
    AntagonistAntagonist919751316
    SB-649868
    AntagonistAntagonist8.921831639
    1-(2,4-dibromo-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea
    AntagonistAntagonist7.9 - 8.615261275
    ACT-078573
    AntagonistAntagonist8.117259994
    TCS-OX2-29
    AntagonistAntagonist7.414643355

    8 Novoseek inferred chemical compound relationships for HCRTR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acth 27.4 2 11443222 (1), 11297593 (1)
    ribonucleic acid 22.3 2 11158046 (1)
    calcium 16.2 2 14691055 (1), 18815029 (1)
    acetylcholine 14.8 3 16352704 (2)
    catecholamine 7.45 1 11600547 (1)
    alanine 3.27 1 12467628 (1)
    histamine 0 1 11682143 (1)
    norepinephrine 0 2 11830291 (2)

    Search CenterWatch for drugs/clinical trials and news about HCRTR2 / OX2R

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HCRTR2 gene: 
    NM_001526.3  

    Unigene Clusters for HCRTR2:

    Hypocretin (orexin) receptor 2
    Hs.151624  [show with all ESTs], Hs.699147  [show with all ESTs]
    Unigene Representative Sequences: AF041245, EF633110
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000370862(uc003pcl.3 uc010jzv.3 uc010jzw.1)

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    Additional mRNA sequence: 

    EF633107.1 EF633108.1 EF633109.1 EF633110.1 

    2 DOTS entries:

    DT.406703  DT.92021265 

    11 AceView cDNA sequences:

    BU680891 BM926746 AF041245 BC035858 NM_001526 D81887 W86471 BX109847 
    CF147829 W86548 BG204832 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HCRTR2 expression in normal human tissues (normalized intensities)      HCRTR2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCAGGCGG
    HCRTR2 Expression
    About this image


    HCRTR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 7

    See HCRTR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HCRTR2

    SOURCE GeneReport for Unigene clusters: Hs.151624 Hs.699147
        SABiosciences Expression via Pathway-Focused PCR Arrays including HCRTR2: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCRTR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HCRTR2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hcrtr21 , 5 hypocretin (orexin) receptor 21, 5 87.96(n)1
    94.58(a)1
      9 (42.48 cM)5
    3872851  NM_198962.31  NP_945200.11 
     762259035 
    chicken
    (Gallus gallus)
    Aves HCRTR21 hypocretin (orexin) receptor 2 80.2(n)
    86.93(a)
      428644  NM_001024584.1  NP_001019755.1 
    lizard
    (Anolis carolinensis)
    Reptilia HCRTR26
    Uncharacterized protein
    81(a)
    1 ↔ 1
    GL343342.1(485979-517327)
    zebrafish
    (Danio rerio)
    Actinopterygii hcrtr21 hypocretin (orexin) receptor 2 68.88(n)
    71.56(a)
      561260  NM_001079868.1  NP_001073337.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NepYr3 G-protein coupled receptor protein
    signaling pathway more
    31(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea tkr-36
    Protein TKR-3, isoform b
    22(a)
    1 → many
    IV(5112929-5122019)


    ENSEMBL Gene Tree for HCRTR2 (if available)
    TreeFam Gene Tree for HCRTR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HCRTR2 gene
    GPR832  PRLHR2  NPFFR22  NPY5R2  NPY4R2  TACR12  TACR32  NPY1R2  
    NPY2R2  NPFFR12  QRFPR2  HCRTR12  TACR22  
    4 SIMAP similar genes for HCRTR2 using alignment to 2 protein entries:     OX2R_HUMAN (see all proteins):
    HCRTR1    DRD3    NPFFR2    PRLHR

    HCRTR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2516 SNPs in HCRTR2 are shown (see all 2516)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0445094
    ----see VAR_0445092 I V mis40--------
    rs1996485601,2
    --54899872(+) GTGTG-/TTTTTGA 1 -- int10--------
    rs1418413231,2
    C--54924048(+) CCACT-/ATAAAA 1 -- int10--------
    rs1125070381,2
    C--54924222(+) CAGTT-/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1995890171,2
    C--54930440(+) AAAGA-/TTTTTTT 1 -- int10--------
    rs766833511,2
    C--54941983(+) GGGGGA/GAAAAA 1 -- int10--------
    rs94642031,2
    C,F,H--54942310(+) GTTTGG/ATTTGC 1 -- us2k1 tfbs320Minor allele frequency- A:0.10NS EA NA WA 2340
    rs93824601,2
    C,F,H--54942670(+) TAAATC/AATCTA 1 -- us2k120Minor allele frequency- A:0.20NS EA CSA WA NA 2758
    rs93824611,2
    C,F,H--54942884(+) TACATA/GTAAAA 1 -- us2k18Minor allele frequency- G:0.06NS EA NA CSA WA 661
    rs558666391,2
    C,F--54942951(+) TATTGC/TTACTT 1 -- us2k17Minor allele frequency- T:0.49WA NA CSA EA 365

    HapMap Linkage Disequilibrium report for HCRTR2 (55039050 - 55147418 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HCRTR2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv6849n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): HCRTR2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HCRTR2
    DNA2.0 Custom Variant and Variant Library Synthesis for HCRTR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602393    OMIM disorders: --

    20/21 diseases for HCRTR2 (see all 21):    About MalaCards
    cluster headache    narcolepsy    headache    myotonic dystrophy type 1
    sleep disorder    cerebritis    myotonic dystrophy    sleep apnea
    pheochromocytoma    panic disorder    mood disorder    albinism
    autism spectrum disorder    migraine    pertussis    obesity
    anorexia nervosa    duodenitis    adenoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for HCRTR2:
    Sleep disorder

    HCRTR2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    5 Novoseek inferred disease relationships for HCRTR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    narcolepsy 89.6 25 15246829 (2), 14580598 (2), 11282968 (2), 10973318 (1) (see all 14)
    cluster headache 66.6 8 17883525 (1), 15477554 (1), 17376114 (1), 18399985 (1) (see all 6)
    adenoma adrenocortical 49.6 2 11830291 (1)
    pheochromocytoma 13 4 11600547 (2), 11830291 (1)
    obesity 0 1 19489767 (1)

    Genetic Association Database (GAD): HCRTR2
    Human Genome Epidemiology (HuGE) Navigator: HCRTR2 (18 documents)

    Export disorders for HCRTR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HCRTR2 gene, integrated from 9 sources (see all 107):
    (articles sorted by number of sources associating them with HCRTR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. (PubMed id 9491897)1, 2, 3 Sakurai T....Yanagisawa M. (1998)
    2. Haplotype Analysis Confirms the Association Between the HCRTR2 Gene and Cluster Headache. (PubMed id 18399985)1, 4, 9 Rainero I....Pinessi L. (2008)
    3. The 1246G-->A polymorphism of the HCRTR2 gene is not associated with migraine. (PubMed id 17645762)1, 4, 9 Pinessi L....Vaula G. (2007)
    4. Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis. (PubMed id 17563843)1, 4, 9 Rainero I....Pinessi L. (2007)
    5. The G1246A polymorphism in the hypocretin receptor 2 gene is not associated with treatment response in cluster headache. (PubMed id 17376114)1, 4, 9 Schurks M....Rosskopf D. (2007)
    6. Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene. (PubMed id 16554494)1, 4, 9 Schurks M....Rosskopf D. (2006)
    7. Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. (PubMed id 15978554)1, 4, 9 Meerabux J....Yoshikawa T. (2005)
    8. Association between migraine and the G1246A polymorphism in the hypocretin receptor 2 gene. (PubMed id 17883525)1, 4, 9 Schurks M....Rosskopf D. (2007)
    9. Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity. (PubMed id 15274044)1, 4, 9 Thompson M.D....Moldofsky H. (2004)
    10. A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache. (PubMed id 15477554)1, 4, 9 Rainero I....Pinessi L. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3062 HGNC: 4849 AceView: HCRTR2 Ensembl:ENSG00000137252 euGenes: HUgn3062
    ECgene: HCRTR2 Kegg: 3062 H-InvDB: HCRTR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HCRTR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HCRTR2 gene:
    Search GeneIP for patents involving HCRTR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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