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Aliases for HCRTR2 Gene

Aliases for HCRTR2 Gene

  • Hypocretin (Orexin) Receptor 2 2 3
  • Hypocretin Receptor Type 2 3 4
  • Ox-2-R 3 4
  • Ox2-R 3 4
  • OX2R 3 4
  • Orexin Receptor Type 2 3
  • Orexin Type-2 Receptor 3

External Ids for HCRTR2 Gene

Previous GeneCards Identifiers for HCRTR2 Gene

  • GC06P055041
  • GC06P055085
  • GC06P055147
  • GC06P054873

Summaries for HCRTR2 Gene

Entrez Gene Summary for HCRTR2 Gene

  • The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

GeneCards Summary for HCRTR2 Gene

HCRTR2 (Hypocretin (Orexin) Receptor 2) is a Protein Coding gene. Diseases associated with HCRTR2 include cluster headache and headache. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include peptide hormone binding and orexin receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for HCRTR2 Gene

  • Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides

Tocris Summary for HCRTR2 Gene

  • The OX2 receptors, also known as hypocretin receptor 2, are located primarily in the cerebral cortex, paraventricular hypothalamus, nucleus accumbens, subthalamic and paraventricular thalamus where they are thought to regulate sleep-wakefulness. The OX2 receptor displays equal affinity for Orexin A and Orexin B. The human OX2 receptor gene has been localized to chromosome 6 (6p11-q11).

Gene Wiki entry for HCRTR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCRTR2 Gene

Genomics for HCRTR2 Gene

Regulatory Elements for HCRTR2 Gene

Genomic Location for HCRTR2 Gene

55,106,460 bp from pter
55,282,620 bp from pter
176,161 bases
Plus strand

Genomic View for HCRTR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HCRTR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCRTR2 Gene

Proteins for HCRTR2 Gene

  • Protein details for HCRTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Orexin receptor type 2
    Protein Accession:
    Secondary Accessions:
    • Q5VTM0

    Protein attributes for HCRTR2 Gene

    444 amino acids
    Molecular mass:
    50694 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HCRTR2 Gene

neXtProt entry for HCRTR2 Gene

Proteomics data for HCRTR2 Gene at MOPED

Post-translational modifications for HCRTR2 Gene

  • Glycosylation at Asn14, Asn22, and Asn202
  • Modification sites at PhosphoSitePlus

Other Protein References for HCRTR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HCRTR2 (Orexin R2/HCRTR2)

No data available for DME Specific Peptides for HCRTR2 Gene

Domains for HCRTR2 Gene

Gene Families for HCRTR2 Gene

Protein Domains for HCRTR2 Gene

Suggested Antigen Peptide Sequences for HCRTR2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HCRTR2: view

Function for HCRTR2 Gene

Molecular function for HCRTR2 Gene

GENATLAS Biochemistry:
hypocretin receptor 2,G protein coupled receptor superfamily binding both HCRT isoforms A and B
UniProtKB/Swiss-Prot Function:
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides

Gene Ontology (GO) - Molecular Function for HCRTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008188 neuropeptide receptor activity TAS 9491897
GO:0016499 orexin receptor activity IBA --
GO:0017046 peptide hormone binding IEA --
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with HCRTR2: view

Phenotypes for HCRTR2 Gene

genes like me logo Genes that share phenotypes with HCRTR2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCRTR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HCRTR2 Gene

Localization for HCRTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCRTR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for HCRTR2 Gene COMPARTMENTS Subcellular localization image for HCRTR2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for HCRTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9491897
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HCRTR2: view

Pathways for HCRTR2 Gene

genes like me logo Genes that share pathways with HCRTR2: view

Pathways by source for HCRTR2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HCRTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007268 synaptic transmission TAS 9491897
GO:0007631 feeding behavior IEA --
genes like me logo Genes that share ontologies with HCRTR2: view

Drugs for HCRTR2 Gene

(4) Tocris Compounds for HCRTR2 Gene

Compound Action Cas Number
[Ala11,D-Leu15]-Orexin B Potent, selective OX2 receptor agonist [532932-99-3]
EMPA Highly potent and selective OX2 antagonist; brain penetrant [680590-49-2]
JNJ 10397049 Selective OX2 receptor antagonist [708275-58-5]
TCS OX2 29 Potent and selective OX2 antagonist [372523-75-6]

(5) ApexBio Compounds for HCRTR2 Gene

Compound Action Cas Number
Allopurinol [315-30-0]
Almorexant hydrochloride OX1R/OX2R antagonist [913358-93-7]
MK-4305 OX1/OX2 atagonist,potent and selective [1030377-33-3]
SB-334867 free base [792173-99-0]
SB408124 OX(1)receptor antagonist [288150-92-5]

(14) IUPHAR Ligand for HCRTR2 Gene

Ligand Type Action Affinity Pubmed IDs
orexin-A Agonist Full agonist 10.2
suvorexant Antagonist Antagonist 9.3
[3H]SB-674042 Antagonist Antagonist 9.2
orexin-B Agonist Full agonist 9.2
SB-649868 Antagonist Antagonist 9.1
N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulphonyl)-amino]-N-pyridin-3-ylmethyl-acetamide Antagonist Antagonist 9
MK-6096 Antagonist Antagonist 8.6
ACT-078573 Antagonist Antagonist 7.9
SB-408124 Antagonist Antagonist 7.6
SB-334867 Antagonist Antagonist 7.5
TCS-OX2-29 Antagonist Antagonist 7.4
[Ala11, D-Leu15]orexin-B Agonist Full agonist 7.3
1-(2-bromo-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea Antagonist Antagonist 6.1
1-(2,4-dibromo-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea Antagonist Antagonist 5.8

(8) Novoseek inferred chemical compound relationships for HCRTR2 Gene

Compound -log(P) Hits PubMed IDs
acth 27.4 2
ribonucleic acid 22.3 1
calcium 16.2 2
acetylcholine 14.8 2
catecholamine 7.45 1
genes like me logo Genes that share compounds with HCRTR2: view

Transcripts for HCRTR2 Gene

mRNA/cDNA for HCRTR2 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HCRTR2 Gene

Hypocretin (orexin) receptor 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCRTR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCRTR2 Gene

No ASD Table

Relevant External Links for HCRTR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HCRTR2 Gene

mRNA expression in normal human tissues for HCRTR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HCRTR2 Gene

This gene is overexpressed in Brain - Hypothalamus (9.4), Brain - Substantia nigra (5.6), and Brain - Anterior cingulate cortex (BA24) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HCRTR2 Gene

SOURCE GeneReport for Unigene cluster for HCRTR2 Gene Hs.151624

genes like me logo Genes that share expressions with HCRTR2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for HCRTR2 Gene

Orthologs for HCRTR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HCRTR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HCRTR2 35
  • 89.86 (n)
  • 96.85 (a)
  • 97 (a)
(Canis familiaris)
Mammalia HCRTR2 35
  • 93.09 (n)
  • 97.75 (a)
  • 98 (a)
(Mus musculus)
Mammalia Hcrtr2 35
  • 87.96 (n)
  • 94.58 (a)
Hcrtr2 16
Hcrtr2 36
  • 91 (a)
(Pan troglodytes)
Mammalia HCRTR2 35
  • 99.55 (n)
  • 99.1 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Hcrtr2 35
  • 88.04 (n)
  • 94.58 (a)
(Monodelphis domestica)
Mammalia HCRTR2 36
  • 84 (a)
(Gallus gallus)
Aves HCRTR2 35
  • 80.2 (n)
  • 86.93 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia HCRTR2 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hcrtr2 35
  • 75.09 (n)
  • 84.05 (a)
(Danio rerio)
Actinopterygii hcrtr2 35
  • 68.88 (n)
  • 71.56 (a)
hcrtr2 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta NepYr 37
  • 31 (a)
  • 17 (a)
(Caenorhabditis elegans)
Secernentea npr-2 35
  • 42.7 (n)
  • 29.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for HCRTR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HCRTR2 Gene

Gene Tree for HCRTR2 (if available)
Gene Tree for HCRTR2 (if available)

Paralogs for HCRTR2 Gene

(16) SIMAP similar genes for HCRTR2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HCRTR2: view

Variants for HCRTR2 Gene

Sequence variations from dbSNP and Humsavar for HCRTR2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9370402 -- 55,216,198(+) catct(C/T)ttaat intron-variant
rs9370400 -- 55,192,537(+) TGAGC(A/C)GTGAT intron-variant
rs9370399 -- 55,180,227(+) TCAAA(A/C)GTTTA intron-variant
rs9370398 -- 55,176,225(+) TTTGA(A/G)GAGAC intron-variant
rs9370397 -- 55,174,157(+) CCCCA(C/T)CCCCC upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HCRTR2 Gene

Variant ID Type Subtype PubMed ID
dgv6849n71 CNV Gain 21882294

Relevant External Links for HCRTR2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCRTR2 Gene

Disorders for HCRTR2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HCRTR2 Gene in MalaCards »

(3) Diseases for HCRTR2 Gene

(1) University of Copenhagen DISEASES for HCRTR2 Gene

(5) Novoseek inferred disease relationships for HCRTR2 Gene

Disease -log(P) Hits PubMed IDs
narcolepsy 89.6 17
cluster headache 66.6 6
adenoma adrenocortical 49.6 1
pheochromocytoma 13 3
obesity 0 1

Relevant External Links for HCRTR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HCRTR2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for HCRTR2 Gene

Publications for HCRTR2 Gene

  1. Hypocretin/orexin, sleep and narcolepsy. (PMID: 11340621) Hungs M. … Mignot E. (Bioessays 2001) 3 4 23
  2. Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. (PMID: 11723285) Olafsdottir B.R. … Gulcher J.R. (Neurology 2001) 3 4 23
  3. Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity. (PMID: 15274044) Thompson M.D. … Moldofsky H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004) 3 23 48
  4. A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache. (PMID: 15477554) Rainero I. … Pinessi L. (Neurology 2004) 3 23 48
  5. Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. (PMID: 15978554) Meerabux J. … Yoshikawa T. (Biol. Psychiatry 2005) 3 23 48

Products for HCRTR2 Gene

Sources for HCRTR2 Gene

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