Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HCRTR1 Gene

protein-coding   GIFtS: 67
GCID: GC01P032083

Hypocretin (Orexin) Receptor 1

  See HCRTR1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Hypocretin (Orexin) Receptor 11 2     Orexin Receptor-12
Hypocretin Receptor Type 12 3     ox-1-R2
OX1R2 5     ox1-R2
Hypocretin Receptor 12     Ox-1-R3
Hypocretin Receptor-12     Ox1-R3
Orexin Receptor 12     Ox1R3
Orexin Receptor Type 12     

External Ids:    HGNC: 48481   Entrez Gene: 30612   Ensembl: ENSG000001217647   OMIM: 6023925   UniProtKB: O436133   

Export aliases for HCRTR1 gene to outside databases

Previous GC identifers: GC01M031859 GC01P031069 GC01P031509 GC01P031587 GC01P031753 GC01P031857 GC01P030200


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HCRTR1 Gene:
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior.
The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a
G-protein coupled receptor that binds orexin A and orexin B. (provided by RefSeq, Jan 2009)

GeneCards Summary for HCRTR1 Gene:
HCRTR1 (hypocretin (orexin) receptor 1) is a protein-coding gene. Diseases associated with HCRTR1 include pertussis, and sleep disorder. GO annotations related to this gene include orexin receptor activity and G-protein coupled receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: OX1R_HUMAN, O43613
Function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B
neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the
phospholipase C mediated signaling cascade (By similarity)

summary for HCRTR1 Gene:
The OX1 receptors, also known as hypocretin receptor 1, are located primarily in the ventromedial
hypothalamus, locus coeruleus, median raphe, hippocampus and taenia tecta where they are thought to regulate
sleep-wakefulness and energy homeostasis. The OX1 receptor displays higher affinity for Orexin A over Orexin
B. The human OX1 receptor gene has been localized to chromosome 1 (1p33).

Gene Wiki entry for HCRTR1 (Hypocretin receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HCRTR1 gene promoter:
         c-Fos   NF-1   AP-1   HOXA3   C/EBPalpha   ZIC2/Zic2   c-Jun   LyF-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHCRTR1 promoter sequence
   Search Chromatin IP Primers for HCRTR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HCRTR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33   Ensembl cytogenetic band:  1p35.2   HGNC cytogenetic band: 1p33

HCRTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HCRTR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P032083:  view genomic region     (about GC identifiers)

Start:
32,083,287 bp from pter      End:
32,098,119 bp from pter
Size:
14,833 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: OX1R_HUMAN, O43613 (See protein sequence)
Recommended Name: Orexin receptor type 1  
Size: 425 amino acids; 47536 Da
Secondary accessions: A8K3A6 Q9HBV6

Explore the universe of human proteins at neXtProt for HCRTR1: NX_O43613

Explore proteomics data for HCRTR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn194
  • Modification sites at PhosphoSitePlus

  • See HCRTR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001516.2  
    ENSEMBL proteins: 
     ENSP00000362810   ENSP00000362809   ENSP00000384387  
    Reactome Protein details: O43613

    HCRTR1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HCRTR1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HCRTR1
    GenScript Custom Purified and Recombinant Proteins Services for HCRTR1
    Novus Biologicals HCRTR1 Proteins
    Novus Biologicals HCRTR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HCRTR1

     
    Search eBioscience for Proteins for HCRTR1 

     
    antibodies-online proteins for HCRTR1 (4 products) 

     
    antibodies-online peptides for HCRTR1

    HCRTR1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HCRTR1
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HCRTR1
    OriGene Custom Antibody Services for HCRTR1
    Novus Biologicals HCRTR1 Antibodies
    Abcam antibodies for HCRTR1
    Cloud-Clone Corp. Antibodies for HCRTR1
    ThermoFisher Antibodies for HCRTR1
    antibodies-online antibodies for HCRTR1 (60 products) 

    HCRTR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HCRTR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HCRTR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HCRTR1
    Cloud-Clone Corp. CLIAs for HCRTR1
    Search eBioscience for ELISAs for HCRTR1 
    antibodies-online kits for HCRTR1 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HCRTR: GPCR / Class A : Hypocretin (orexin) receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: OX1 receptor
    Orexin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004059 Orexin_rcpt_1
     IPR000204 Orexin_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O43613

    ProtoNet protein and cluster: O43613

    2 Blocks protein domains:
    IPB000204 Orexin receptor signature
    IPB004059 Orexin receptor type 1 signature


    UniProtKB/Swiss-Prot: OX1R_HUMAN, O43613
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with HCRTR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OX1R_HUMAN, O43613
    Function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B
    neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the
    phospholipase C mediated signaling cascade (By similarity)

         Genatlas biochemistry entry for HCRTR1:
    hypocretin receptor 1,G protein coupled receptor superfamily,selective for HCRT,isoform A

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS9491897
    GO:0016499orexin receptor activity IEA--
    GO:0017046peptide hormone binding IEA--
         
    Find genes that share ontologies with HCRTR1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hcrtr1):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with HCRTR1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HCRTR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HCRTR1:
    hsa-mir-335-5p (MIRT018468)

    Block miRNA regulation of human, mouse, rat HCRTR1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HCRTR1:
    hsa-miR-548s
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HCRTR1
    Predesigned siRNA for gene silencing in human, mouse, rat HCRTR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HCRTR1

    Clone
    Products:
         
    OriGene clones in human, mouse for HCRTR1 (see all 6)
    OriGene ORF clones in mouse, rat for HCRTR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HCRTR1 (NM_001525)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HCRTR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCRTR1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HCRTR1
    Browse ESI BIO Cell Lines and PureStem Progenitors for HCRTR1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCRTR1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11073) for HCRTR1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    OX1R_HUMAN, O43613: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9491897
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with HCRTR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HCRTR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    Orexin and neuropeptides FF and QRFP bind to their respective receptors0.00
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46


    Find genes that share SuperPaths with HCRTR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HCRTR1
        GPCRs, Class A Rhodopsin-like

    2 Reactome Pathways for HCRTR1
        Orexin and neuropeptides FF and QRFP bind to their respective receptors
    G alpha (q) signalling events


    1 Kegg Pathway  (Kegg details for HCRTR1):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HCRTR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HCRTR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HCRTR1 (O436133 ENSP000003628104) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNR1P215543, ENSP000003585114I2D: score=1 STRING: ENSP00000358511
    HCRTO436123, ENSP000002933304I2D: score=2 STRING: ENSP00000293330
    NPYP013033I2D: score=1 
    APPENSP000002849814STRING: ENSP00000284981
    AVPR1AENSP000002991784STRING: ENSP00000299178
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0007268synaptic transmission TAS9491897
    GO:0007631feeding behavior IEA--

    Find genes that share ontologies with HCRTR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HCRTR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SB 408124Selective non-peptide OX1 antagonist[288150-92-5]
    SB 334867Selective non-peptide OX1 antagonist[249889-64-3]

    Selected IUPHAR Ligands for HCRTR1 (OX1 receptor) (see all 13)    About this table
    LigandTypeActionAffinityPubmed IDs
    orexin-A
    AgonistFull agonist6.5 - 10.210498827 12702704 12606634 11403934 11266181 11162621 11250867 9491897 14691055 12208495 18599270
    suvorexant
    AntagonistAntagonist9.320565075
    [3H]SB-674042
    AntagonistAntagonist8.3 - 9.219542319 20404073 14691055
    orexin-B
    AgonistFull agonist5.8 - 9.210498827 12606634 11403934 11162621 21362456 9491897 14691055 12208495
    SB-649868
    AntagonistAntagonist9.121831639
    MK-6096
    AntagonistAntagonist8.622019562
    ACT-078573
    AntagonistAntagonist7.917259994
    SB-410220
    AntagonistAntagonist7.714691055
    SB-408124
    AntagonistAntagonist7.2 - 7.614691055 19542319
    SB-334867
    AntagonistAntagonist7.4 - 7.511459658 19542319

    Selected Novoseek inferred chemical compound relationships for HCRTR1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bisindolylmaleimide 40.9 1 16006563 (1)
    thapsigargin 31.3 1 17050705 (1)
    acth 30.8 1 11557621 (1)
    calcium 27.4 15 17188243 (3), 11435939 (1), 12446588 (1), 19118115 (1) (see all 9)
    isoflurane 19.6 1 17243642 (1)
    inositol 1,4,5 trisphosphate 18.1 2 19583704 (1), 17188243 (1)
    alanine 16.2 1 12467628 (1)
    adenylate 14.2 1 11158046 (1)
    ribonucleic acid 13.1 2 11158046 (1)
    acetylcholine 4.58 7 16352704 (3), 17243642 (2), 19699722 (1)



    Find genes that share compounds with HCRTR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HCRTR1 gene: 
    NM_001525.2  

    Unigene Cluster for HCRTR1:

    Hypocretin (orexin) receptor 1
    Hs.388226  [show with all ESTs]
    Unigene Representative Sequence: AK290521
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485464 ENST00000468521(uc001btc.4) ENST00000373706(uc010ogl.2)
    ENST00000373705 ENST00000403528(uc009vtx.2 uc001btd.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HCRTR1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HCRTR1:
    hsa-miR-548s
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HCRTR1
    Predesigned siRNA for gene silencing in human, mouse, rat HCRTR1
    Clone
    Products:
         
    OriGene clones in human, mouse for HCRTR1 (see all 6)
    OriGene ORF clones in mouse, rat for HCRTR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HCRTR1 (NM_001525)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HCRTR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCRTR1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HCRTR1
    OriGene qSTAR qPCR primer pairs in human, mouse for HCRTR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HCRTR1
      QuantiTect SYBR Green Assays in human, mouse, rat HCRTR1
      QuantiFast Probe-based Assays in human, mouse, rat HCRTR1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11073) for HCRTR1 

    Additional mRNA sequence: 

    AF041243.1 AK290521.1 BC035686.1 BC074796.2 

    3 DOTS entries:

    DT.92014038  DT.97798848  DT.100647816 

    16 AceView cDNA sequences:

    BQ269289 BC035686 BX409735 CR605321 BQ285933 AF041243 BC074796 BM920548 
    NM_001525 BX119589 CF147830 AL535838 R55704 R40951 R55705 AL535837 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HCRTR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAAGCAAG
    HCRTR1 Expression
    About this image


    HCRTR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Septum   
    HCRTR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HCRTR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.388226
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HCRTR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HCRTR1
    OriGene qSTAR qPCR primer pairs in human, mouse for HCRTR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HCRTR1
    QuantiTect SYBR Green Assays in human, mouse, rat HCRTR1
    QuantiFast Probe-based Assays in human, mouse, rat HCRTR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCRTR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for HCRTR1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hcrtr11 , 5 hypocretin (orexin) receptor 11, 5 89.32(n)1
    93.98(a)1
      4 (63.43 cM)5
    2307771  NM_001163027.11  NP_001156499.11 
     1301302175 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    25(a)
    many ↔ many
    GL343406.1(591195-608254)
    zebrafish
    (Danio rerio)
    Actinopterygii npffr1l36
    neuropeptide FF receptor 1 like 3
    26(a)
    many ↔ many
    10(520128-534210) ENSDARG00000010712
    fruit fly
    (Drosophila melanogaster)
    Insecta NepYr3 G-protein coupled receptor protein
    signaling pathway more
    29(a)     --


    ENSEMBL Gene Tree for HCRTR1 (if available)
    TreeFam Gene Tree for HCRTR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HCRTR1 gene
    GPR832  HCRTR22  PRLHR2  NPFFR22  NPY5R2  NPY4R2  TACR12  TACR32  
    NPY1R2  NPY2R2  NPFFR12  QRFPR2  TACR22  
    9 SIMAP similar genes for HCRTR1 using alignment to 2 protein entries:     OX1R_HUMAN (see all proteins):
    HCRTR2    GHSR    hA2aR    DRD2    GIR    TACR1
    QRFPR    PRLHR    NPFFR2

    Find genes that share paralogs with HCRTR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HCRTR1 (see all 428)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs794082461,2
    F--32081457(+) TCTCCT/CCACAC 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1912646441,2
    --32081487(+) ACAAAC/TGCCAA 1 -- us2k10--------
    rs1837701221,2
    --32081504(+) GGGACA/GGATCA 1 -- us2k10--------
    rs1421526841,2
    --32081567(+) GCCCAA/CCCCCT 1 -- us2k10--------
    rs720090731,2
    C--32081717(+) GCACA-/CACG  
            
    CACAC
    1 -- us2k10--------
    rs350475431,2
    C--32081720(+) CACACGC/-ACACA 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs598536841,2
    C--32081720(+) CACAC-/GCAC  
            
    ACACA
    1 -- us2k10--------
    rs2005263851,2
    C--32081720(+) CACACA/GCACAC 1 -- us2k10--------
    rs105632171,2
    C--32081721(+) acacgCA/-cacac 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1138498181,2
    C,F--32081757(+) CTTCTG/AAGTCC 1 -- us2k12Minor allele frequency- A:0.18WA 120

    HapMap Linkage Disequilibrium report for HCRTR1 (32083287 - 32098119 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HCRTR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv209n71CNV Loss21882294
    nsv470708CNV Loss18288195
    nsv10062CNV Gain+Loss18304495
    dgv46e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): HCRTR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HCRTR1
    DNA2.0 Custom Variant and Variant Library Synthesis for HCRTR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602392    OMIM disorders: --

    8 diseases for HCRTR1:    
    About MalaCards
    pertussis    sleep disorder    myotonic dystrophy type 1    eating disorder
    insomnia    narcolepsy    pheochromocytoma    neuroblastoma

    1 disease from the University of Copenhagen DISEASES database for HCRTR1:
    Sleep disorder

    Find genes that share disorders with HCRTR1           About GenesLikeMe

    6 Novoseek inferred disease relationships for HCRTR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    narcolepsy 82.8 6 10973318 (1), 11723285 (1), 18714784 (1), 15070772 (1)
    adenoma adrenocortical 42 3 11830291 (2), 15797953 (1)
    pheochromocytoma 25.4 4 11830291 (2), 12208495 (1), 11600547 (1)
    eating disorders 5.27 2 17002215 (1), 16634704 (1)
    tumors 0.853 1 15797953 (1)
    ischemia 0 3 15620413 (2), 15893406 (1)

    Genetic Association Database (GAD): HCRTR1
    Human Genome Epidemiology (HuGE) Navigator: HCRTR1 (8 documents)

    Export disorders for HCRTR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HCRTR1 gene, integrated from 10 sources (see all 158):
    (articles sorted by number of sources associating them with HCRTR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. (PubMed id 9491897)1, 2, 3 Sakurai T....Yanagisawa M. (Cell 1998)
    2. The orexin 1 receptor (HCRTR1) gene as a susceptibility gene contributing to polydipsia-hyponatremia in schizophrenia. (PubMed id 17999203)1, 4, 9 Fukunaka Y....Nakamura J. (Neuromolecular Med. 2007)
    3. Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. (PubMed id 15978554)1, 4, 9 Meerabux J....Yoshikawa T. (Biol. Psychiatry 2005)
    4. Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. (PubMed id 11723285)1, 2, 9 Olafsdottir B.R.... Gulcher J.R. (Neurology 2001)
    5. Hypocretin/orexin, sleep and narcolepsy. (PubMed id 11340621)1, 2, 9 Hungs M. and Mignot E. (Bioessays 2001)
    6. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. (PubMed id 10973318)1, 2, 9 Peyron C.... Mignot E. (Nat. Med. 2000)
    7. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    8. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    9. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3061 HGNC: 4848 AceView: HCRTR1 Ensembl:ENSG00000121764 euGenes: HUgn3061
    ECgene: HCRTR1 Kegg: 3061 H-InvDB: HCRTR1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HCRTR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HCRTR1 gene:
    Search GeneIP for patents involving HCRTR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HCRTR1
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for HCRTR1 (Orexin R1/HCRTR1)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HCRTR1   OriGene RNAi products in human, mouse, rat for HCRTR1  
     OriGene qPCR primer pairs and template standards for HCRTR1   OriGene Protein Over-expression Lysate for HCRTR1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HCRTR1  
     OriGene qSTAR qPCR primer pairs in human, mouse for HCRTR1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HCRTR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HCRTR1   OriGene Custom Protein Services for HCRTR1  

     
     
     Block miRNA regulation of human, mouse, rat HCRTR1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HCRTR1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HCRTR1 Predesigned siRNA for gene silencing in human, mouse, rat HCRTR1
     QuantiFast Probe-based Assays in human, mouse, rat HCRTR1 QuantiTect SYBR Green Assays in human, mouse, rat HCRTR1
     PCR Arrays including human, mouse, rat HCRTR1 Search Chromatin IP Primers for HCRTR1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HCRTR1  Search GeneGlobe Interaction Network for HCRTR1
     Regulatory tfbs in HCRTR1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HCRTR1 GenScript cDNA clones with any tag delivered in your preferred vector for HCRTR1
     GenScript Custom Assay Services for HCRTR1 GenScript Custom overexpressing Cell Line Services for HCRTR1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for HCRTR1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HCRTR1 antibodies
     HCRTR1 proteins
     HCRTR1 lysates
     Antibodies for HCRTR1
     See all of Abcam's Antibodies, Kits and Proteins for HCRTR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HCRTR1
     Antibodies for HCRTR1
     ELISAs for HCRTR1
     CLIAs for HCRTR1



     Browse ESI BIO Cell Lines and PureStem Progenitors for HCRTR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCRTR1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HCRTR1
     SwitchGear Promoter luciferase reporter plasmids for HCRTR1
     ThermoFisher Antibodies for HCRTR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCRTR1
     Browse compounds at ApexBio
     Search Addgene for plasmids for HCRTR1
      Search eBioscience for proteins for HCRTR1
      Search eBioscience for elisas for HCRTR1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HCRTR1
     antibodies-online antibodies for HCRTR1 (60 products)
     antibodies-online kits for HCRTR1 (7 products)
     antibodies-online peptides for HCRTR1
     antibodies-online proteins for HCRTR1 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HCRTR1 gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4