HCRTR1 Gene
protein-coding GIFtS: 63
GCID: GC01P032083
|
|
hypocretin (orexin) receptor 1
| |
Aliases
for HCRTR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hypocretin (Orexin) Receptor 11 2 | | Orexin Receptor-12 | | OX1R1 2 | | Ox-1-R3 | | Hypocretin Receptor Type 12 3 | | Ox1-R3 | | Hypocretin Receptor 12 | | Ox-1-R3 | | Hypocretin Receptor-12 | | Ox1-R3 | | Orexin Receptor 12 | | Ox1R3 | | Orexin Receptor Type 12 | | |
Export aliases for HCRTR1 gene to outside databasesPrevious GC identifers: GC01M031859 GC01P031069 GC01P031509 GC01P031587 GC01P031753 GC01P031857 GC01P030200 |
Summaries
for HCRTR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HCRTR1:
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. Theencoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-proteincoupled receptor that binds orexin A and orexin B. (provided by RefSeq, Jan 2009)
UniProtKB/Swiss-Prot: OX1R_HUMAN, O43613Function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide.Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase Cmediated signaling cascade (By similarity)
 summary
for HCRTR1: The OX1 receptors, also known as hypocretin receptor 1, are located primarily in the ventromedial
hypothalamus, locus coeruleus, median raphe, hippocampus and taenia tecta where they are thought to regulate
sleep-wakefulness and energy homeostasis. The OX1 receptor displays higher affinity for Orexin A over Orexin
B. The human OX1 receptor gene has been localized to chromosome 1 (1p33).
Gene Wiki entry for HCRTR1 (Hypocretin receptor 1)
|
Genomic Views
for HCRTR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HCRTR1 gene promoter:
c-Fos NF-1 AP-1 HOXA3 C/EBPalpha ZIC2/Zic2 c-Jun LyF-1 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for HCRTR1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HCRTR1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p33 Ensembl cytogenetic band: 1p35.2 HGNC cytogenetic band: 1p33HCRTR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P032083: view genomic region
(about GC identifiers)
Start:
|
32,083,287 bp from pter |
End:
|
32,098,119 bp from pter |
Size:
|
14,833 bases |
Orientation:
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plus strand |
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Proteins
for HCRTR1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OX1R_HUMAN, O43613 (See
protein sequence)Recommended Name: Orexin receptor type 1 Size: 425 amino acids; 47536 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A8K3A6 Q9HBV6Explore the universe of human proteins at neXtProt for HCRTR1: NX_O43613
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43613
HCRTR1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001516.2
ENSEMBL proteins: ENSP00000362810 ENSP00000362809 ENSP00000384387 Reactome Protein details: O43613
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
HCRTR1 for ontologies About GeneDecksing
HCRTR1 Antibody Products:
Assay Products for HCRTR1: |
Protein
Domains /
Families
for HCRTR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HCRTR1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43613ProtoNet protein and cluster: O43613 2 Blocks protein families: IPB000204 Orexin receptor signature IPB004059 Orexin receptor type 1 signature
UniProtKB/Swiss-Prot: OX1R_HUMAN, O43613Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for HCRTR1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OX1R_HUMAN, O43613Function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide.Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase Cmediated signaling cascade (By similarity) Genatlas biochemistry entry for HCRTR1:hypocretin receptor 1,G protein coupled receptor superfamily,selective for HCRT,isoform A
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HCRTR1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCRTR1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
HCRTR1 for ontologies About GeneDecksing
Animal Models:
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Hcrtr1):
HCRTR1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HCRTR1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | G alpha (q) signalling events | | | 4 | Orexin and neuropeptides FF and QRFP bind to their respective receptors | | | 5 | Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for HCRTR1
1  BioSystems Pathway for HCRTR1
5/9 
Reactome Pathways for HCRTR1 (see all 9)
1 
Kegg Pathway (Kegg details for HCRTR1):
HCRTR1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HCRTR1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/125 Interacting proteins for HCRTR1 (O436133 ENSP000003628104) via UniProtKB, MINT, STRING, and/or I2D (see all 125)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
HCRTR1 for ontologies About GeneDecksing
|
Drugs & Compounds
for HCRTR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HCRTR1 for compounds About GeneDecksing
Compounds for HCRTR1 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| SB 408124 | Selective non-peptide OX1 antagonist | [288150-92-5] | | SB 334867 | Selective non-peptide OX1 antagonist | [249889-64-3] |
10/13 Novoseek chemical compound relationships for HCRTR1 gene (see all 13) About this table
Search CenterWatch for drugs/clinical trials and news about HCRTR1 / OX1R
|
Transcripts
for HCRTR1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HCRTR1 gene: NM_001525.2 Unigene Cluster for HCRTR1: Hypocretin (orexin) receptor 1 Hs.388226 [show with all ESTs]Unigene Representative Sequence: AK2905215 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000485464 ENST00000468521(uc001btc.4) ENST00000373706(uc010ogl.2)
ENST00000373705 ENST00000403528(uc009vtx.2 uc001btd.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HCRTR1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HCRTR1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HCRTR1 (NM_001525) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HCRTR1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCRTR1 |
Additional cDNA sequence: AF041243.1 AK290521.1 BC035686.1 BC074796.2 3 DOTS entries: DT.92014038 DT.97798848 DT.100647816 16 AceView cDNA sequences: BQ269289 BC035686 BX409735 CR605321 BM920548 AF041243 NM_001525 BC074796 BX119589 BQ285933 AL535838 CF147830 R55704 R40951 R55705 AL535837
GeneLoc Exon Structure
|
Expression
for HCRTR1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HCRTR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAAGCAAG
About this image
See HCRTR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HCRTR1
SOURCE GeneReport for Unigene cluster: Hs.388226
SABiosciences Expression via Pathway-Focused PCR Arrays including HCRTR1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HCRTR1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HCRTR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HCRTR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HCRTR1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCRTR1 |
Orthologs
for HCRTR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HCRTR1 gene from 2/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
37(a) |
1 → many |
Group4.4(791524-802384) |
worm
(Caenorhabditis elegans) |
Secernentea |
npr-141 |
Protein NPR-14 |
43.88(n)
29.25(a) |
|
189211 NM_060882.3 NP_493283.3 |
ENSEMBL Gene Tree for HCRTR1 (if available)
TreeFam Gene Tree for HCRTR1 (if available) |
Paralogs
for HCRTR1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HCRTR1 gene
- GPR832 HCRTR22 PRLHR2 NPFFR22 PPYR12 NPY5R2 TACR12 TACR32
- NPY1R2 QRFPR2 NPFFR12 NPY2R2 TACR22
10 SIMAP similar genes for HCRTR1 using alignment to 2 protein entries: OX1R_HUMAN (see all proteins):HCRTR2 GHSR hA2aR DRD2 GIR TACR1
QRFPR PRLHR NPFFR2 NPFFR1
HCRTR1 for paralogs About GeneDecksing
|
Genomic Variants
for HCRTR1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HCRTR1 (32083287 - 32098119 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for HCRTR1
4 CNVs: 30382 2304 3287 31617
Human Gene Mutation Database (HGMD): HCRTR1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HCRTR1 |
|
Disorders
/ Diseases
for HCRTR1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HCRTR1 for disorders About GeneDecksing
OMIM gene information: 602392
OMIM disorders: --
20/24  diseases for HCRTR1 (see all 24): About MalaCardsmyotonic dystrophy type 1 myotonic dystrophy eating disorder autism spectrum disorder
multiple system atrophy anorexia nervosa differentiating neuroblastoma insomnia
panic disorder mood disorder sleep disorder narcolepsy
pheochromocytoma albinism obesity, resistance to ischemia
duodenitis adenoma obesity pertussis
1 disease from the University of Copenhagen DISEASES database for HCRTR1:Sleep disorder 6 Novoseek disease relationships for HCRTR1 gene About this table
Genetic Association Database (GAD): HCRTR1
Human Genome Epidemiology (HuGE) Navigator: HCRTR1 (8 documents)
Export disorders for HCRTR1 gene to outside databases
|
Publications
for HCRTR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HCRTR1 gene, integrated from 9 sources (see all 157):
(articles sorted by number of sources associating them with HCRTR1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. (PubMed id 9491897)1, 2, 3 Sakurai T....Yanagisawa M. (1998)
- Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. (PubMed id 15978554)1, 4, 9 Meerabux J....Yoshikawa T. (2005)
- Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. (PubMed id 11723285)1, 2, 9 Olafsdottir B.R.... Gulcher J.R. (2001)
- Hypocretin/orexin, sleep and narcolepsy. (PubMed id 11340621)1, 2, 9 Hungs M. and Mignot E. (2001)
- A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. (PubMed id 10973318)1, 2, 9 Peyron C.... Mignot E. (2000)
- To eat or to sleep? Orexin in the regulation of feeding and wakefulness. (PubMed id 11283317)1, 2 Willie J.T.... Yanagisawa M. (2001)
- Cellular localization of orexin receptors in human pituitary. (PubMed id 11443222)1, 9 Blanco M....Beiras A. (2001)
- The orexin 1 receptor (HCRTR1) gene as a susceptibility gene contributing to polydipsia-hyponatremia in schizophrenia. (PubMed id 17999203)1, 9 Fukunaka Y....Nakamura J. (2007)
- Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells. (PubMed id 15797953)1, 9 Spinazzi R....Nussdorfer G.G. (2005)
- Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716. (PubMed id 12690115)1, 9 Hilairet S....Casellas P. (2003)
|
External Searches for HCRTR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HCRTR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HCRTR1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HCRTR1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HCRTR1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HCRTR1 gene:
Search GeneIP for patents involving HCRTR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HCRTR1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | HCRTR1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCRTR1 |
|  |  |  | | | | ThermoFisher Antibodies for HCRTR1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCRTR1 |
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