Aliases for HCRTR1 Gene
External Ids for HCRTR1 Gene
Previous GeneCards Identifiers for HCRTR1 Gene
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
GeneCards Summary for HCRTR1 Gene
HCRTR1 (Hypocretin (Orexin) Receptor 1) is a Protein Coding gene. Diseases associated with HCRTR1 include pertussis and sleep disorder. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and orexin receptor activity. An important paralog of this gene is NPFFR1.
UniProtKB/Swiss-Prot for HCRTR1 Gene
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
The OX1 receptors, also known as hypocretin receptor 1, are located primarily in the ventromedial hypothalamus, locus coeruleus, median raphe, hippocampus and taenia tecta where they are thought to regulate sleep-wakefulness and energy homeostasis. The OX1 receptor displays higher affinity for Orexin A over Orexin B. The human OX1 receptor gene has been localized to chromosome 1 (1p33).