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Aliases for HCRTR1 Gene

Aliases for HCRTR1 Gene

  • Hypocretin (Orexin) Receptor 1 2 3
  • OX1R 3 4 6
  • Hypocretin Receptor Type 1 3 4
  • Ox-1-R 3 4
  • Ox1-R 3 4
  • Orexin Receptor Type 1 3
  • Hypocretin Receptor 1 3
  • Hypocretin Receptor-1 3
  • Orexin Receptor 1 3
  • Orexin Receptor-1 3

External Ids for HCRTR1 Gene

Previous GeneCards Identifiers for HCRTR1 Gene

  • GC01M031859
  • GC01P031069
  • GC01P031509
  • GC01P031753
  • GC01P031857
  • GC01P032083
  • GC01P030200

Summaries for HCRTR1 Gene

Entrez Gene Summary for HCRTR1 Gene

  • The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]

GeneCards Summary for HCRTR1 Gene

HCRTR1 (Hypocretin (Orexin) Receptor 1) is a Protein Coding gene. Diseases associated with HCRTR1 include pertussis and sleep disorder. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and orexin receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for HCRTR1 Gene

  • Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).

Tocris Summary for HCRTR1 Gene

  • The OX1 receptors, also known as hypocretin receptor 1, are located primarily in the ventromedial hypothalamus, locus coeruleus, median raphe, hippocampus and taenia tecta where they are thought to regulate sleep-wakefulness and energy homeostasis. The OX1 receptor displays higher affinity for Orexin A over Orexin B. The human OX1 receptor gene has been localized to chromosome 1 (1p33).

Gene Wiki entry for HCRTR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCRTR1 Gene

Genomics for HCRTR1 Gene

Regulatory Elements for HCRTR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HCRTR1 Gene

31,617,686 bp from pter
31,632,518 bp from pter
14,833 bases
Plus strand

Genomic View for HCRTR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HCRTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCRTR1 Gene

Proteins for HCRTR1 Gene

  • Protein details for HCRTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Orexin receptor type 1
    Protein Accession:
    Secondary Accessions:
    • A8K3A6
    • Q9HBV6

    Protein attributes for HCRTR1 Gene

    425 amino acids
    Molecular mass:
    47536 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HCRTR1 Gene

Proteomics data for HCRTR1 Gene at MOPED

Post-translational modifications for HCRTR1 Gene

  • Glycosylation at Asn194
  • Modification sites at PhosphoSitePlus

Other Protein References for HCRTR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HCRTR1 Gene

Domains for HCRTR1 Gene

Gene Families for HCRTR1 Gene

  • HCRTR :GPCR / Class A : Hypocretin (orexin) receptors

Suggested Antigen Peptide Sequences for HCRTR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O43613
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HCRTR1: view

Function for HCRTR1 Gene

Molecular function for HCRTR1 Gene

GENATLAS Biochemistry: hypocretin receptor 1,G protein coupled receptor superfamily,selective for HCRT,isoform A
UniProtKB/Swiss-Prot Function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).

Gene Ontology (GO) - Molecular Function for HCRTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 9491897
GO:0008188 neuropeptide receptor activity IBA --
GO:0016499 orexin receptor activity IBA --
GO:0017046 peptide hormone binding IEA --
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with HCRTR1: view

Phenotypes for HCRTR1 Gene

genes like me logo Genes that share phenotypes with HCRTR1: view

Animal Model Products

CRISPR Products

miRNA for HCRTR1 Gene

miRTarBase miRNAs that target HCRTR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCRTR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HCRTR1 Gene

Localization for HCRTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCRTR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for HCRTR1 Gene COMPARTMENTS Subcellular localization image for HCRTR1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HCRTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9491897
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HCRTR1: view

Pathways for HCRTR1 Gene

genes like me logo Genes that share pathways with HCRTR1: view

Pathways by source for HCRTR1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HCRTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007268 synaptic transmission TAS 9491897
GO:0007631 feeding behavior IEA --
GO:0032870 cellular response to hormone stimulus IBA --
genes like me logo Genes that share ontologies with HCRTR1: view

Compounds for HCRTR1 Gene

(5) Tocris Compounds for HCRTR1 Gene

Compound Action Cas Number
ACT 335827 Potent and selective OX1 antagonist [1354039-86-3]
OXA (17-33) Potent and selective peptide OX1 antagonist [343268-91-7]
SB 334867 Selective non-peptide OX1 antagonist [792173-99-0]
SB 408124 Selective non-peptide OX1 antagonist [288150-92-5]
SB 674042 Potent and selective non-peptide OX1 antagonist [483313-22-0]

(13) IUPHAR Ligand for HCRTR1 Gene

Ligand Type Action Affinity Pubmed IDs
orexin-A Agonist Full agonist 10.2
suvorexant Antagonist Antagonist 9.3
[3H]SB-674042 Antagonist Antagonist 9.2
orexin-B Agonist Full agonist 9.2
SB-649868 Antagonist Antagonist 9.1
MK-6096 Antagonist Antagonist 8.6
ACT-078573 Antagonist Antagonist 7.9
SB-410220 Antagonist Antagonist 7.7
SB-408124 Antagonist Antagonist 7.6
SB-334867 Antagonist Antagonist 7.5
[Ala11, D-Leu15]orexin-B Agonist Full agonist 7.3
1-(2-bromo-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea Antagonist Antagonist 6.1
1-(2,4-dibromo-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea Antagonist Antagonist 5.8

(13) Novoseek inferred chemical compound relationships for HCRTR1 Gene

Compound -log(P) Hits PubMed IDs
bisindolylmaleimide 40.9 1
thapsigargin 31.3 1
acth 30.8 1
calcium 27.4 11
isoflurane 19.6 1
genes like me logo Genes that share compounds with HCRTR1: view

Transcripts for HCRTR1 Gene

mRNA/cDNA for HCRTR1 Gene

Unigene Clusters for HCRTR1 Gene

Hypocretin (orexin) receptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCRTR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCRTR1 Gene

No ASD Table

Relevant External Links for HCRTR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HCRTR1 Gene

mRNA expression in normal human tissues for HCRTR1 Gene

mRNA differential expression in normal tissues according to GTEx for HCRTR1 Gene

This gene is overexpressed in Brain - Hypothalamus (5.9) and Thyroid (4.1).

SOURCE GeneReport for Unigene cluster for HCRTR1 Gene Hs.388226

genes like me logo Genes that share expressions with HCRTR1: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for HCRTR1 Gene

Orthologs for HCRTR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HCRTR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HCRTR1 35
  • 98.51 (n)
  • 97.65 (a)
  • 98 (a)
(Bos Taurus)
Mammalia HCRTR1 35
  • 91.76 (n)
  • 95.29 (a)
  • 95 (a)
(Canis familiaris)
Mammalia HCRTR1 35
  • 91.29 (n)
  • 94.12 (a)
  • 94 (a)
(Mus musculus)
Mammalia Hcrtr1 35
  • 89.32 (n)
  • 93.98 (a)
Hcrtr1 16
Hcrtr1 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia HCRTR1 36
  • 84 (a)
(Rattus norvegicus)
Mammalia Hcrtr1 35
  • 88.92 (n)
  • 93.73 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
(Danio rerio)
Actinopterygii npffr1l3 36
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta SIFR 36
  • 16 (a)
NepYr 37
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for HCRTR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HCRTR1 Gene

Gene Tree for HCRTR1 (if available)
Gene Tree for HCRTR1 (if available)

Paralogs for HCRTR1 Gene

Selected SIMAP similar genes for HCRTR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HCRTR1: view

Variants for HCRTR1 Gene

Sequence variations from dbSNP and Humsavar for HCRTR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs871634 -- 31,627,566(+) TGGCA(C/G)AGAGG downstream-variant-500B, utr-variant-3-prime
rs950872 -- 31,621,694(-) ATGGC(A/C)TGTGC intron-variant
rs968335 -- 31,620,175(+) AGTGG(A/G)GTGGA intron-variant
rs1056526 -- 31,619,303(+) TGGCG(C/T)GATTA reference, synonymous-codon, missense
rs1056527 -- 31,627,004(+) GCTCC(A/G)GCTCG utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HCRTR1 Gene

Variant ID Type Subtype PubMed ID
dgv46e1 CNV Complex 17122850
nsv10062 CNV Gain+Loss 18304495
dgv209n71 CNV Loss 21882294
nsv470708 CNV Loss 18288195

Relevant External Links for HCRTR1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCRTR1 Gene

Disorders for HCRTR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (6) Diseases for HCRTR1 Gene including...

Search for HCRTR1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for HCRTR1 Gene

(6) Novoseek inferred disease relationships for HCRTR1 Gene

Disease -log(P) Hits PubMed IDs
narcolepsy 82.8 4
adenoma adrenocortical 42 3
pheochromocytoma 25.4 4
eating disorders 5.27 2
tumors 0.853 1

Relevant External Links for HCRTR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HCRTR1: view

No data available for UniProtKB/Swiss-Prot for HCRTR1 Gene

Publications for HCRTR1 Gene

  1. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. (PMID: 10973318) Peyron C. … Mignot E. (Nat. Med. 2000) 3 4 23
  2. Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. (PMID: 11723285) Olafsdottir B.R. … Gulcher J.R. (Neurology 2001) 3 4 23
  3. Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. (PMID: 15978554) Meerabux J. … Yoshikawa T. (Biol. Psychiatry 2005) 3 23 48
  4. The orexin 1 receptor (HCRTR1) gene as a susceptibility gene contributing to polydipsia-hyponatremia in schizophrenia. (PMID: 17999203) Fukunaka Y. … Nakamura J. (Neuromolecular Med. 2007) 3 23 48
  5. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. (PMID: 9491897) Sakurai T. … Yanagisawa M. (Cell 1998) 2 3 4

Products for HCRTR1 Gene

Sources for HCRTR1 Gene

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