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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HCRTR1 Gene

protein-coding   GIFtS: 66
GCID: GC01P032083

Hypocretin (Orexin) Receptor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hypocretin (Orexin) Receptor 11 2     Orexin Receptor-12
Hypocretin Receptor Type 12 3     ox-1-R2
OX1R2     ox1-R2
Hypocretin Receptor 12     Ox-1-R3
Hypocretin Receptor-12     Ox1-R3
Orexin Receptor 12     Ox1R3
Orexin Receptor Type 12     

External Ids:    HGNC: 48481   Entrez Gene: 30612   Ensembl: ENSG000001217647   OMIM: 6023925   UniProtKB: O436133   

Export aliases for HCRTR1 gene to outside databases

Previous GC identifers: GC01M031859 GC01P031069 GC01P031509 GC01P031587 GC01P031753 GC01P031857 GC01P030200


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HCRTR1 Gene:
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior.
The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a
G-protein coupled receptor that binds orexin A and orexin B. (provided by RefSeq, Jan 2009)

GeneCards Summary for HCRTR1 Gene: 
HCRTR1 (hypocretin (orexin) receptor 1) is a protein-coding gene. Diseases associated with HCRTR1 include differentiating neuroblastoma, and narcolepsy, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include orexin receptor activity and G-protein coupled receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: OX1R_HUMAN, O43613
Function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B
neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the
phospholipase C mediated signaling cascade (By similarity)

summary for HCRTR1 Gene:
The OX1 receptors, also known as hypocretin receptor 1, are located primarily in the ventromedial
hypothalamus, locus coeruleus, median raphe, hippocampus and taenia tecta where they are thought to regulate
sleep-wakefulness and energy homeostasis. The OX1 receptor displays higher affinity for Orexin A over Orexin
B. The human OX1 receptor gene has been localized to chromosome 1 (1p33).

Gene Wiki entry for HCRTR1 (Hypocretin receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HCRTR1 gene promoter:
         c-Fos   NF-1   AP-1   HOXA3   C/EBPalpha   ZIC2/Zic2   c-Jun   LyF-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHCRTR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HCRTR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HCRTR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33   Ensembl cytogenetic band:  1p35.2   HGNC cytogenetic band: 1p33

HCRTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HCRTR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P032083:  view genomic region     (about GC identifiers)

Start:
32,083,287 bp from pter      End:
32,098,119 bp from pter
Size:
14,833 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OX1R_HUMAN, O43613 (See protein sequence)
Recommended Name: Orexin receptor type 1  
Size: 425 amino acids; 47536 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A8K3A6 Q9HBV6

Explore the universe of human proteins at neXtProt for HCRTR1: NX_O43613

Explore proteomics data for HCRTR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43613

  • HCRTR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HCRTR1 Protein Expression
    REFSEQ proteins: NP_001516.2  
    ENSEMBL proteins: 
     ENSP00000362810   ENSP00000362809   ENSP00000384387  
    Reactome Protein details: O43613
    Human Recombinant Protein Products for HCRTR1: 
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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9491897
    GO:0016021integral to membrane ----

    HCRTR1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HCRTR: GPCR / Class A : Hypocretin (orexin) receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: OX1 receptor 
    Orexin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004059 Orexin_rcpt_1
     IPR000204 Orexin_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O43613

    ProtoNet protein and cluster: O43613

    2 Blocks protein domains:
    IPB000204 Orexin receptor signature
    IPB004059 Orexin receptor type 1 signature


    UniProtKB/Swiss-Prot: OX1R_HUMAN, O43613
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HCRTR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OX1R_HUMAN, O43613
    Function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B
    neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the
    phospholipase C mediated signaling cascade (By similarity)

         Genatlas biochemistry entry for HCRTR1:
    hypocretin receptor 1,G protein coupled receptor superfamily,selective for HCRT,isoform A

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS9491897
    GO:0016499orexin receptor activity IEA--
    GO:0017046peptide hormone binding IEA--
         
    HCRTR1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hcrtr1):
     behavior/neurological  nervous system 

    HCRTR1 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HCRTR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    5Orexin and neuropeptides FF and QRFP bind to their respective receptors
    Orexin and neuropeptides FF and QRFP bind to their respective receptors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for HCRTR1
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    1 BioSystems Pathway for HCRTR1
        GPCRs, Class A Rhodopsin-like

    5/9        Reactome Pathways for HCRTR1 (see all 9)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Orexin and neuropeptides FF and QRFP bind to their respective receptors
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for HCRTR1):
        Neuroactive ligand-receptor interaction


    HCRTR1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HCRTR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/125 Interacting proteins for HCRTR1 (O436133 ENSP000003628104) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNR1P215543, ENSP000003585114I2D: score=1 STRING: ENSP00000358511
    HCRTO436123, ENSP000002933304I2D: score=2 STRING: ENSP00000293330
    NPYP013033I2D: score=1 
    APPENSP000002849814STRING: ENSP00000284981
    CCKENSP000003356574STRING: ENSP00000335657
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0007268synaptic transmission TAS9491897
    GO:0007631feeding behavior IEA--

    HCRTR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HCRTR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HCRTR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SB 408124Selective non-peptide OX1 antagonist[288150-92-5]
    SB 334867Selective non-peptide OX1 antagonist[249889-64-3]

    10/13 IUPHAR Ligands for HCRTR1 (OX1 receptor) (see all 13)    About this table 
    LigandTypeActionAffinityPubmed IDs
    orexin-A
    AgonistFull agonist6.5 - 10.210498827 12702704 12606634 11403934 11266181 11162621 11250867 9491897 14691055 12208495 18599270
    suvorexant
    AntagonistAntagonist9.320565075
    [3H]SB-674042
    AntagonistAntagonist8.3 - 9.219542319 20404073 14691055
    orexin-B
    AgonistFull agonist5.8 - 9.210498827 12606634 11403934 11162621 21362456 9491897 14691055 12208495
    SB-649868
    AntagonistAntagonist9.121831639
    MK-6096
    AntagonistAntagonist8.622019562
    ACT-078573
    AntagonistAntagonist7.917259994
    SB-410220
    AntagonistAntagonist7.714691055
    SB-408124
    AntagonistAntagonist7.2 - 7.614691055 19542319
    SB-334867
    AntagonistAntagonist7.4 - 7.511459658 19542319

    10/13 Novoseek inferred chemical compound relationships for HCRTR1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bisindolylmaleimide 40.9 1 16006563 (1)
    thapsigargin 31.3 1 17050705 (1)
    acth 30.8 1 11557621 (1)
    calcium 27.4 15 17188243 (3), 11435939 (1), 12446588 (1), 19118115 (1) (see all 9)
    isoflurane 19.6 1 17243642 (1)
    inositol 1,4,5 trisphosphate 18.1 2 19583704 (1), 17188243 (1)
    alanine 16.2 1 12467628 (1)
    adenylate 14.2 1 11158046 (1)
    ribonucleic acid 13.1 2 11158046 (1)
    acetylcholine 4.58 7 16352704 (3), 17243642 (2), 19699722 (1)

    Search CenterWatch for drugs/clinical trials and news about HCRTR1 / OX1R

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for HCRTR1 gene: 
    NM_001525.2  

    Unigene Cluster for HCRTR1:

    Hypocretin (orexin) receptor 1
    Hs.388226  [show with all ESTs]
    Unigene Representative Sequence: AK290521
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485464 ENST00000468521(uc001btc.4) ENST00000373706(uc010ogl.2)
    ENST00000373705 ENST00000403528(uc009vtx.2 uc001btd.2)
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    Additional mRNA sequence: 

    AF041243.1 AK290521.1 BC035686.1 BC074796.2 

    3 DOTS entries:

    DT.92014038  DT.97798848  DT.100647816 

    16 AceView cDNA sequences:

    CR605321 BQ269289 BX409735 BC035686 BQ285933 NM_001525 AF041243 BX119589 
    BM920548 BC074796 CF147830 AL535838 R55704 R40951 R55705 AL535837 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HCRTR1 expression in normal human tissues (normalized intensities)      HCRTR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAAGCAAG
    HCRTR1 Expression
    About this image


    HCRTR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Septum   

    See HCRTR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HCRTR1

    SOURCE GeneReport for Unigene cluster: Hs.388226
        SABiosciences Expression via Pathway-Focused PCR Arrays including HCRTR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HCRTR1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hcrtr11 , 5 hypocretin (orexin) receptor 11, 5 89.32(n)1
    93.98(a)1
      4 (63.43 cM)5
    2307771  NM_001163027.11  NP_001156499.11 
     1301302175 
    fruit fly
    (Drosophila melanogaster)
    Insecta NepYr3 G-protein coupled receptor protein
    signaling pathway more
    29(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea npr-141 Protein NPR-14 43.88(n)
    29.25(a)
      189211  NM_060882.3  NP_493283.3 


    ENSEMBL Gene Tree for HCRTR1 (if available)
    TreeFam Gene Tree for HCRTR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HCRTR1 gene
    GPR832  HCRTR22  PRLHR2  NPFFR22  NPY5R2  NPY4R2  TACR12  TACR32  
    NPY1R2  NPY2R2  NPFFR12  QRFPR2  TACR22  
    9 SIMAP similar genes for HCRTR1 using alignment to 2 protein entries:     OX1R_HUMAN (see all proteins):
    HCRTR2    GHSR    hA2aR    DRD2    GIR    TACR1
    QRFPR    PRLHR    NPFFR2

    HCRTR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/428 SNPs in HCRTR1 are shown (see all 428)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs794082461,2
    F--32081457(+) TCTCCT/CCACAC 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1912646441,2
    --32081487(+) ACAAAC/TGCCAA 1 -- us2k10--------
    rs1837701221,2
    --32081504(+) GGGACA/GGATCA 1 -- us2k10--------
    rs1421526841,2
    --32081567(+) GCCCAA/CCCCCT 1 -- us2k10--------
    rs720090731,2
    C--32081717(+) GCACA-/CACG  
            
    CACAC
    1 -- us2k10--------
    rs350475431,2
    C--32081720(+) CACACGC/-ACACA 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs598536841,2
    C--32081720(+) CACAC-/GCAC  
            
    ACACA
    1 -- us2k10--------
    rs2005263851,2
    C--32081720(+) CACACA/GCACAC 1 -- us2k10--------
    rs105632171,2
    C--32081721(+) acacgCA/-cacac 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1138498181,2
    C,F--32081757(+) CTTCTG/AAGTCC 1 -- us2k12Minor allele frequency- A:0.18WA 120

    HapMap Linkage Disequilibrium report for HCRTR1 (32083287 - 32098119 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HCRTR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv209n71CNV Loss21882294
    nsv470708CNV Loss18288195
    nsv10062CNV Gain+Loss18304495
    dgv46e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): HCRTR1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HCRTR1
    DNA2.0 Custom Variant and Variant Library Synthesis for HCRTR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602392    OMIM disorders: --

    20/23 diseases for HCRTR1 (see all 23):    About MalaCards
    differentiating neuroblastoma    narcolepsy    myotonic dystrophy type 1    eating disorder
    sleep disorder    pheochromocytoma    myotonic dystrophy    multiple system atrophy
    pertussis    panic disorder    autism spectrum disorder    mood disorder
    albinism    anorexia nervosa    neuroblastoma    duodenitis
    ischemia    obesity    migraine    adenoma

    1 disease from the University of Copenhagen DISEASES database for HCRTR1:
    Sleep disorder

    HCRTR1 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for HCRTR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    narcolepsy 82.8 6 10973318 (1), 11723285 (1), 18714784 (1), 15070772 (1)
    adenoma adrenocortical 42 3 11830291 (2), 15797953 (1)
    pheochromocytoma 25.4 4 11830291 (2), 12208495 (1), 11600547 (1)
    eating disorders 5.27 2 17002215 (1), 16634704 (1)
    tumors 0.853 1 15797953 (1)
    ischemia 0 3 15620413 (2), 15893406 (1)

    Genetic Association Database (GAD): HCRTR1
    Human Genome Epidemiology (HuGE) Navigator: HCRTR1 (8 documents)

    Export disorders for HCRTR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HCRTR1 gene, integrated from 9 sources (see all 158):
    (articles sorted by number of sources associating them with HCRTR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. (PubMed id 9491897)1, 2, 3 Sakurai T....Yanagisawa M. (1998)
    2. The orexin 1 receptor (HCRTR1) gene as a susceptibility gene contributing to polydipsia-hyponatremia in schizophrenia. (PubMed id 17999203)1, 4, 9 Fukunaka Y....Nakamura J. (2007)
    3. Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. (PubMed id 15978554)1, 4, 9 Meerabux J....Yoshikawa T. (2005)
    4. Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. (PubMed id 11723285)1, 2, 9 Olafsdottir B.R.... Gulcher J.R. (2001)
    5. Hypocretin/orexin, sleep and narcolepsy. (PubMed id 11340621)1, 2, 9 Hungs M. and Mignot E. (2001)
    6. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. (PubMed id 10973318)1, 2, 9 Peyron C.... Mignot E. (2000)
    7. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    8. Comprehensive copy number variant (CNV) analysis of n euronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (2010)
    9. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3061 HGNC: 4848 AceView: HCRTR1 Ensembl:ENSG00000121764 euGenes: HUgn3061
    ECgene: HCRTR1 Kegg: 3061 H-InvDB: HCRTR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HCRTR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HCRTR1 gene:
    Search GeneIP for patents involving HCRTR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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