Aliases for HCRT Gene
External Ids for HCRT Gene
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]
GeneCards Summary for HCRT Gene
HCRT (Hypocretin (Orexin) Neuropeptide Precursor) is a Protein Coding gene. Diseases associated with HCRT include recurrent hypersomnia and narcolepsy 1. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include type 1 hypocretin receptor binding and type 2 hypocretin receptor binding.
UniProtKB/Swiss-Prot for HCRT Gene
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity