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HCRT Gene

protein-coding   GIFtS: 59
GCID: GC17M040337

Hypocretin (Orexin) Neuropeptide Precursor

  See HCRT-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hypocretin (Orexin) Neuropeptide Precursor1 2     orexin2
OX2 3 5     Hcrt3
prepro-orexin1 2     Hypocretin3
PPOX2 3     PPORX3
NRCLP12 5     

External Ids:    HGNC: 48471   Entrez Gene: 30602   Ensembl: ENSG000001616107   OMIM: 6023585   UniProtKB: O436123   

Export aliases for HCRT gene to outside databases

Previous GC identifers: GC17M039901 GC17M042492 GC17M040244 GC17M040709 GC17M037589 GC17M036101


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HCRT Gene:
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides,
orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled
receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may
also play a role in feeding behavior, metabolism, and homeostasis. (provided by RefSeq, Jan 2010)

GeneCards Summary for HCRT Gene:
HCRT (hypocretin (orexin) neuropeptide precursor) is a protein-coding gene. Diseases associated with HCRT include narcolepsy, and sleep apnea. GO annotations related to this gene include type 1 hypocretin receptor binding and type 2 hypocretin receptor binding.

UniProtKB/Swiss-Prot: OREX_HUMAN, O43612
Function: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness,
possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic
functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal
balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high
affinity, whereas orexin-B binds only to OX2R with a similar high affinity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HCRT gene promoter:
         NRSF form 1   Tal-1beta   NRSF form 2   CREB   HOXA5   deltaCREB   STAT3   ARP-1   FOXJ2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHCRT promoter sequence
   Search Chromatin IP Primers for HCRT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HCRT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21

HCRT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HCRT gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040337:  view genomic region     (about GC identifiers)

Start:
40,336,078 bp from pter      End:
40,337,470 bp from pter
Size:
1,393 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OREX_HUMAN, O43612 (See protein sequence)
Recommended Name: Orexin precursor  
Size: 131 amino acids; 13363 Da
4 PDB 3D structures from and Proteopedia for HCRT:
1CQ0 (3D)        1R02 (3D)        1UVQ (3D)        1WSO (3D)    

Explore the universe of human proteins at neXtProt for HCRT: NX_O43612

Explore proteomics data for HCRT at MOPED

Post-translational modifications: 

  • Specific enzymatic cleavages at paired basic residues yield the different active peptides1
  • Modification sites at neXtProt

  • See HCRT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001515.1  
    ENSEMBL proteins: 
     ENSP00000293330  
    Reactome Protein details: O43612

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online peptides for HCRT

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    antibodies-online kits for HCRT (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR001704 Orexin

    Graphical View of Domain Structure for InterPro Entry O43612

    ProtoNet protein and cluster: O43612

    1 Blocks protein domain: IPB001704 Prepro-orexin signature

    UniProtKB/Swiss-Prot: OREX_HUMAN, O43612
    Similarity: Belongs to the orexin family


    Find genes that share domains with HCRT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OREX_HUMAN, O43612
    Function: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness,
    possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic
    functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal
    balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high
    affinity, whereas orexin-B binds only to OX2R with a similar high affinity

         Genatlas biochemistry entry for HCRT:
    hypocretin neuropeptide precursor of isoforms A and B,expressed in lateral hypothalamus and adjacent
    areas,potential mediator in the central feedback mechanism,that regulates feeding behavior,homolog to
    secretin,susceptibility gene for narcolepsy

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031771type 1 hypocretin receptor binding IEA--
    GO:0031772type 2 hypocretin receptor binding IEA--
         
    Find genes that share ontologies with HCRT           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HCRT:
     Increased homologous recombina 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hcrt):
     behavior/neurological  cardiovascular system  growth/size/body  homeostasis/metabolism  muscle 
     nervous system  respiratory system 

    Find genes that share phenotypes with HCRT           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HCRT

    miRNA
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    miRTarBase miRNAs that target HCRT:
    hsa-mir-30a-5p (MIRT028501)

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    1 qRT-PCR Assays for microRNA that regulate HCRT:
    hsa-miR-137
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OREX_HUMAN, O43612: Rough endoplasmic reticulum (By similarity). Cytoplasmic vesicle (By similarity). Cell
    junction, synapse (By similarity). Note=Associated with perikaryal rough endoplasmic reticulum as well as
    cytoplasmic large granular vesicles at synapses (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    nucleus3
    endoplasmic reticulum2
    cytosol1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005737cytoplasm ----
    GO:0005791rough endoplasmic reticulum IEA--
    GO:0008021synaptic vesicle TAS9419374
    GO:0030054cell junction IEA--

    Find genes that share ontologies with HCRT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HCRT About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    Orexin and neuropeptides FF and QRFP bind to their respective receptors0.00
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46


    Find genes that share SuperPaths with HCRT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for HCRT
        Orexin and neuropeptides FF and QRFP bind to their respective receptors
    G alpha (q) signalling events


        Pathway & Disease-focused RT2 Profiler PCR Arrays including HCRT: 
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HCRT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HCRT (O436123 ENSP000002933304) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206305P019093I2D: score=1 
    ENSG00000232062P019093I2D: score=1 
    HLA-DQA1P019093I2D: score=1 
    HCRTR1O436133, ENSP000003628104I2D: score=2 STRING: ENSP00000362810
    HCRTR2O436143, ENSP000003598994I2D: score=2 STRING: ENSP00000359899
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007204positive regulation of cytosolic calcium ion concentration IEA--
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0007268synaptic transmission TAS9419374

    Find genes that share ontologies with HCRT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HCRT (OREX)

    1 DrugBank Compound for HCRT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyroglutamic Acid-- 98-79-3target--10592235

    Selected Novoseek inferred chemical compound relationships for HCRT gene (see all 61)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    modafinil 75.4 15 15652995 (3), 15532213 (1), 19630720 (1), 17712350 (1) (see all 7)
    gamma-hydroxybutyrate 73.3 1 15989524 (1)
    enterostatin 67.5 2 11732637 (1), 10857385 (1)
    oxyntomodulin 53.8 2 16340035 (1), 16949016 (1)
    cocaine 52.9 37 15330675 (2), 16326123 (2), 10929926 (1), 11872319 (1) (see all 28)
    octadecaneuropeptide 48.6 4 15146610 (1), 15107726 (1)
    amphetamine 48.5 18 12151553 (3), 10657511 (1), 15777192 (1), 15146610 (1) (see all 13)
    histamine 46.1 47 19238805 (4), 12388591 (3), 18295497 (2), 11682143 (2) (see all 21)
    npff 45 6 12609745 (4), 12714592 (1)
    dopamine 44 40 15532213 (2), 19891960 (2), 12403989 (1), 16476667 (1) (see all 27)



    Find genes that share compounds with HCRT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HCRT gene: 
    NM_001524.1  

    Unigene Cluster for HCRT:

    Hypocretin (orexin) neuropeptide precursor
    Hs.158348  [show with all ESTs]
    Unigene Representative Sequence: AW163686
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000293330(uc002hzc.1)
    miRNA
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    Additional mRNA sequence: AF041240.1 

    1 DOTS entry:

    DT.40127958 

    6 AceView cDNA sequences:

    AF041240 NM_001524 AW163686 AW163085 BG194545 BX284083 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HCRT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCTTCCTT
    HCRT Expression
    About this image


    HCRT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Thalamus
     
     Neural Tube (Nervous System)
             Diencephalon
    HCRT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HCRT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158348

    UniProtKB/Swiss-Prot: OREX_HUMAN, O43612
    Tissue specificity: Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested
    (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HCRT: 
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCRT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HCRT gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hcrt1 , 5 hypocretin1, 5 80(n)1
    80(a)1
      11 (63.60 cM)5
    151711  NM_010410.21  NP_034540.11 
     1007610695 
    chicken
    (Gallus gallus)
    Aves HCRT6
    Gallus gallus hypocretin (orexin) neuropeptide pre...
    48(a)
    1 ↔ 1
    27(4857256-4858313)
    lizard
    (Anolis carolinensis)
    Reptilia HCRT6
    hypocretin (orexin) neuropeptide precursor
    43(a)
    1 ↔ 1
    6(72761703-72767864)
    zebrafish
    (Danio rerio)
    Actinopterygii hcrt6
    hypocretin (orexin) neuropeptide precursor
    34(a)
    1 ↔ 1
    3(17181219-17185315) ENSDARG00000070932


    ENSEMBL Gene Tree for HCRT (if available)
    TreeFam Gene Tree for HCRT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HCRT (see all 76)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0116334
    Narcolepsy 1 (NRCLP1)4--see VAR_0116332 L R mis40--------
    rs1048945741,2
    Cpathogenic141125593(-) GCTACG/TGCTGC 2 R L mis10--------
    rs346401311,2
    F--40338843(+) TCTTTC/TTTTTT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs288791961,2
    C,F--40338928(+) CGCCTT/CCCGGG 1 -- us2k11Minor allele frequency- C:0.00WA 2
    rs288635521,2
    C,F--40338931(+) CTCCCT/GGGTTC 1 -- us2k11Minor allele frequency- G:0.00WA 2
    rs129531101,2
    C,F--40338997(+) acgccC/Tagcta 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs286960121,2
    C,F--40339099(+) CCAAAA/GTGCTG 1 -- us2k11Minor allele frequency- G:0.00WA 2
    rs37603911,2
    C,F--41124652(+) AATTAT/CGGCTC 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs587557791,2
    C,F--41124706(+) CCCCGC/TTAATT 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1458718321,2
    --41124922(+) GCATCC/GTAGGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HCRT (40336078 - 40337470 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HCRT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908244CNV Loss21882294
    dgv3169n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): HCRT
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HCRT
    DNA2.0 Custom Variant and Variant Library Synthesis for HCRT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602358   
    OMIM disorders: 161400  
    UniProtKB/Swiss-Prot: OREX_HUMAN, O43612
  • Narcolepsy 1 (NRCLP1) [MIM:161400]: Neurological disabling sleep disorder, characterized by excessive
    daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy,
    hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions,
    which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a
    sporadically occurring disorder but familial clustering has been observed. Note=The disease is caused by
    mutations affecting the gene represented in this entry. Human narcolepsy is associated with a deficient orexin
    system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most
    narcoleptic patients

  • Selected diseases for HCRT (see all 33):    
    About MalaCards
    narcolepsy    sleep apnea    obstructive sleep apnea    narcolepsy 1
    kleine-levin syndrome    sleep disorder    hypersomnia    acute disseminated encephalomyelitis
    recurrent hypersomnia    restless legs syndrome    guillain-barre syndrome    corticobasal degeneration
    drug addiction    cannabis dependence    craniopharyngioma    autonomic dysfunction
    phenylketonuria    complex regional pain syndrome    progressive supranuclear palsy    eating disorder

    3 diseases from the University of Copenhagen DISEASES database for HCRT:
    Sleep disorder     Neurodegenerative disease     Brain disease

    Find genes that share disorders with HCRT           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HCRT gene (see all 61)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    narcolepsy 97.7 645 20129934 (8), 19725250 (6), 19158946 (6), 19555382 (6) (see all 99)
    cataplexy 96.9 160 19725250 (7), 12405608 (6), 20129934 (6), 16006155 (3) (see all 71)
    sleep paralysis 90.2 3 17702265 (1), 15729517 (1)
    idiopathic hypersomnia 80.3 18 19238805 (3), 19928388 (2), 11869432 (2), 14638887 (1) (see all 6)
    hypersomnia recurrent 75.5 6 18226957 (2)
    hypersomnia posttraumatic 71.8 1 14638887 (1)
    obesity 55.4 28 15862893 (4), 18595438 (2), 16188908 (2), 16054072 (2) (see all 14)
    hypothalamic tumors 48 2 15645360 (1), 16986734 (1)
    apnea sleep 47.5 2 15627867 (1), 18812827 (1)
    neurological disorders 47.3 16 18819824 (3), 17245312 (1), 11756606 (1), 16006155 (1) (see all 12)

    Genetic Association Database (GAD): HCRT
    Human Genome Epidemiology (HuGE) Navigator: HCRT (11 documents)

    Export disorders for HCRT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HCRT gene, integrated from 10 sources (see all 609):
    (articles sorted by number of sources associating them with HCRT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. (PubMed id 9491897)1, 2, 3 Sakurai T....Yanagisawa M. (Cell 1998)
    2. Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. (PubMed id 15978554)1, 4, 9 Meerabux J....Yoshikawa T. (Biol. Psychiatry 2005)
    3. A prepro-orexin gene polymorphism is associated with narcolepsy. (PubMed id 11148249)1, 4, 9 Gencik M....Epplen J.T. (Neurology 2001)
    4. Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor. (PubMed id 16429482)1, 2, 9 Takai T.... Ikegami T. (J. Pept. Sci. 2006)
    5. Hypocretin/orexin, sleep and narcolepsy. (PubMed id 11340621)1, 2, 9 Hungs M. and Mignot E. (Bioessays 2001)
    6. Polymorphisms in the vicinity of the hypocretin/orexin are not associated with human narcolepsy. (PubMed id 11723284)1, 4, 9 Hungs M....Mignot E. (Neurology 2001)
    7. To eat or to sleep? Orexin in the regulation of feeding and wakefulness. (PubMed id 11283317)1, 2, 9 Willie J.T.... Yanagisawa M. (Annu. Rev. Neurosci. 2001)
    8. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. (PubMed id 10973318)1, 2, 9 Peyron C.... Mignot E. (Nat. Med. 2000)
    9. Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B. (PubMed id 10583376)1, 2, 9 Lee J.-H.... Lee W. (Eur. J. Biochem. 1999)
    10. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3060 HGNC: 4847 AceView: HCRT Ensembl:ENSG00000161610 euGenes: HUgn3060
    ECgene: HCRT H-InvDB: HCRT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HCRT Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/015

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HCRT gene:
    Search GeneIP for patents involving HCRT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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