Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HCP5 Gene

Subcategory (RNA class) for HCP5 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for HCP5 Gene

  • HLA Complex P5 (Non-Protein Coding) 2 3 5
  • HLA Complex Protein P5 3 4
  • HLA Class I Histocompatibility Antigen Protein P5 3
  • MHC Class I Region ORF 3
  • HLA Complex P5 2
  • Protein P5-1 4
  • D6S2650E 3
  • 6S2650E 3
  • P5-1 3

External Ids for HCP5 Gene

Previous GeneCards Identifiers for HCP5 Gene

  • GC06P031201
  • GC06P031535
  • GC06P031538
  • GC01M241088
  • GC06P031430
  • GC06Pj31419
  • GC06P031372
  • GC06P031375

Summaries for HCP5 Gene

GeneCards Summary for HCP5 Gene

HCP5 (HLA Complex P5 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with HCP5 include Herpes Zoster and Hypersensitivity Syndrome, Carbamazepine-Induced.

Additional gene information for HCP5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCP5 Gene

Genomics for HCP5 Gene

Regulatory Elements for HCP5 Gene

Enhancers for HCP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H031353 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7.2 -44.5 -44511 6 HDGF PKNOX1 ATF1 NSD2 ZNF2 GLIS2 ZNF143 ZNF207 FOS RUNX3 HLA-C HLA-B DDX39B ENSG00000271581 MICA LY6G5B ATF6B RPL7P4 MICA-AS1 SKIV2L
GH06H031567 2 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +177.7 177717 22 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B TNF DDX39B LY6G5B ATF6B LSM2 TCF19 MDC1 DHX16 NFKBIL1 C6orf47
GH06H031545 1.2 ENCODE 4.2 +146.8 146831 3 MLX YBX1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D DDX39B LSM2 LY6G5B ATF6B DHX16 MDC1 NRM TCF19 NFKBIL1 MICA
GH06H031398 1.4 ENCODE dbSUPER 0.7 +1.2 1210 5 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B MICA-AS1 HLA-C MICA MICB PSORS1C3 HLA-E ENSG00000271581 PSORS1C2 SKIV2L POU5F1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HCP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for HCP5 Gene

Chromosome:
6
Start:
31,400,702 bp from pter
End:
31,477,506 bp from pter
Size:
76,805 bases
Orientation:
Plus strand

Genomic View for HCP5 Gene

Genes around HCP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCP5 Gene

Proteins for HCP5 Gene

  • Protein details for HCP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6MZN7-HCP5_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen protein P5
    Protein Accession:
    Q6MZN7
    Secondary Accessions:
    • Q04490

    Protein attributes for HCP5 Gene

    Size:
    132 amino acids
    Molecular mass:
    14098 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • HCP5 is localized within the MHC class I region, but is not structurally related to MHC class I genes. HCP5 is related in sequence to human endogenous retroviruses HERV-L and HERV-16. It has sequence homology with retroviral Pol genes in HERV retroviral element; thus, it is itself a good candidate to interact with HIV-1, possibly through an antisense mechanism against retroviral transcript.
    • Variation Gly-112 is associated with low viral loads in untreated HIV patients. The level of circulating virus in the plasma of HIV patients (viral set point) varies among individuals during the nonsymptomatic phase preceding the progression to AIDS. This polymorphism explains 9.6% of the total variation in set point and is associated with the HLA-B*5701 allele, which has the strongest described protective impact on HIV disease progression. However, it is possible that HPC5 polymorphism, and not HLA-B*5701 allele, plays a direct role in the control in viremia in HIV patients.
    SequenceCaution:
    • Sequence=AAA59986.1; Type=Frameshift; Positions=58, 125; Evidence={ECO:0000305};

neXtProt entry for HCP5 Gene

Post-translational modifications for HCP5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HCP5 Gene

Domains & Families for HCP5 Gene

Protein Domains for HCP5 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for HCP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HCP5: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HCP5 Gene

Function for HCP5 Gene

Phenotypes From GWAS Catalog for HCP5 Gene

Phenotypes for HCP5 Gene

genes like me logo Genes that share phenotypes with HCP5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HCP5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HCP5 Gene

Localization for HCP5 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HCP5 Gene

Pathways & Interactions for HCP5 Gene

No Data Available

Interacting Proteins for HCP5 Gene

Gene Ontology (GO) - Biological Process for HCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 8462994
genes like me logo Genes that share ontologies with HCP5: view

No data available for Pathways by source and SIGNOR curated interactions for HCP5 Gene

Drugs & Compounds for HCP5 Gene

No Compound Related Data Available

Transcripts for HCP5 Gene

Unigene Clusters for HCP5 Gene

HLA complex P5 (non-protein coding):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HCP5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HCP5 Gene

No ASD Table

Relevant External Links for HCP5 Gene

GeneLoc Exon Structure for
HCP5
ECgene alternative splicing isoforms for
HCP5

Expression for HCP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HCP5 Gene

mRNA differential expression in normal tissues according to GTEx for HCP5 Gene

This gene is overexpressed in Whole Blood (x7.7) and Spleen (x5.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HCP5 Gene



NURSA nuclear receptor signaling pathways regulating expression of HCP5 Gene:

HCP5

SOURCE GeneReport for Unigene cluster for HCP5 Gene:

Hs.691948

mRNA Expression by UniProt/SwissProt for HCP5 Gene:

Q6MZN7-HCP5_HUMAN
Tissue specificity: Expressed in lymphoid tissues; Detected in spleen as well as in B-cell lines, NK cell lines and activated lymphocytes.
genes like me logo Genes that share expression patterns with HCP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HCP5 Gene

Orthologs for HCP5 Gene

Evolution for HCP5 Gene

ENSEMBL:
Gene Tree for HCP5 (if available)
TreeFam:
Gene Tree for HCP5 (if available)

No data available for Orthologs for HCP5 Gene

Paralogs for HCP5 Gene

No data available for Paralogs for HCP5 Gene

Variants for HCP5 Gene

Sequence variations from dbSNP and Humsavar for HCP5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000188565 -- 31,466,265(+) GCACT(C/T)ACCAC downstream-variant-500B
rs1001390427 -- 31,462,872(+) GGCCA(A/G)GATTC upstream-variant-2KB
rs1001437142 -- 31,463,162(+) TAAAG(C/T)CCTCG upstream-variant-2KB
rs1002414123 -- 31,461,192(+) GCCGT(A/G)TGTTG upstream-variant-2KB
rs1003992193 -- 31,463,930(+) CTATT(A/T)CCTGT nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for HCP5 Gene

Variant ID Type Subtype PubMed ID
dgv10393n54 CNV loss 21841781
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10453n54 CNV loss 21841781
dgv10454n54 CNV gain 21841781
dgv10457n54 CNV loss 21841781
dgv10458n54 CNV loss 21841781
dgv10459n54 CNV loss 21841781
dgv1098e199 CNV deletion 23128226
dgv1751e212 CNV gain 25503493
dgv1752e212 CNV loss 25503493
dgv213e55 CNV gain 17911159
dgv214e55 CNV gain 17911159
dgv215e55 CNV loss 17911159
dgv5942n100 CNV loss 25217958
dgv5943n100 CNV gain+loss 25217958
dgv5944n100 CNV loss 25217958
dgv747n27 CNV loss 19166990
dgv995e201 CNV deletion 23290073
esv2432528 CNV deletion 19546169
esv26480 CNV loss 19812545
esv2731822 CNV deletion 23290073
esv2752123 CNV gain 17911159
esv2759414 CNV gain+loss 17122850
esv2762584 CNV loss 21179565
esv2763959 CNV gain+loss 21179565
esv29968 CNV gain 17803354
esv3160 OTHER sequence alteration 18987735
esv33563 CNV gain+loss 17666407
esv34063 CNV loss 18971310
esv3411275 CNV duplication 20981092
esv34118 CNV loss 18971310
esv3576141 CNV gain 25503493
esv3608563 CNV loss 21293372
esv3890819 CNV loss 25118596
nsv1022499 CNV gain 25217958
nsv1030802 CNV gain 25217958
nsv1073969 CNV deletion 25765185
nsv10820 CNV gain+loss 18304495
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv1161369 CNV deletion 26073780
nsv428140 CNV gain+loss 18775914
nsv435829 CNV deletion 17901297
nsv441990 CNV loss 18776908
nsv462854 CNV gain 19166990
nsv511868 CNV loss 21212237
nsv513736 CNV insertion 21212237
nsv517441 CNV gain+loss 19592680
nsv5246 CNV deletion 18451855
nsv601880 CNV gain+loss 21841781
nsv818409 CNV loss 17921354
nsv823497 CNV loss 20364138
nsv970363 CNV duplication 23825009

Relevant External Links for HCP5 Gene

Human Gene Mutation Database (HGMD)
HCP5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HCP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HCP5 Gene

Disorders for HCP5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HCP5 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
herpes zoster
  • herpes zona
hypersensitivity syndrome, carbamazepine-induced
  • toxic epidermal necrolysis
- elite association - COSMIC cancer census association via MalaCards
Search HCP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HCP5

Genetic Association Database (GAD)
HCP5
Human Genome Epidemiology (HuGE) Navigator
HCP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HCP5
genes like me logo Genes that share disorders with HCP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HCP5 Gene

Publications for HCP5 Gene

  1. The P5 multicopy gene family in the MHC is related in sequence to human endogenous retroviruses HERV-L and HERV-16. (PMID: 10199916) Kulski JK … Dawkins RL (Immunogenetics 1999) 2 3 4 60
  2. A novel coding sequence belonging to a new multicopy gene family mapping within the human MHC class I region. (PMID: 8462994) Vernet C … Pontarotti P (Immunogenetics 1993) 2 3 4 60
  3. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. (PMID: 21051598) International HIV Controllers Study … Zhao M (Science (New York, N.Y.) 2010) 3 45 60
  4. Use of the HCP5 single nucleotide polymorphism to predict hypersensitivity reactions to abacavir: correlation with HLA-B*5701. (PMID: 20534626) Rodríguez-Nóvoa S … Soriano V (The Journal of antimicrobial chemotherapy 2010) 3 45 60
  5. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J … NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) (PLoS genetics 2009) 3 45 60

Products for HCP5 Gene

Sources for HCP5 Gene

Content
Loading form....