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Aliases for HCP5 Gene

Subcategory (RNA class) for HCP5 Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for HCP5 Gene

  • HLA Complex P5 (Non-Protein Coding) 2 3
  • HLA Complex Protein P5 3 4
  • HLA Class I Histocompatibility Antigen Protein P5 3
  • MHC Class I Region ORF 3
  • HLA Complex P5 2
  • Protein P5-1 4
  • D6S2650E 3
  • 6S2650E 3
  • P5-1 3

External Ids for HCP5 Gene

Previous GeneCards Identifiers for HCP5 Gene

  • GC06P031201
  • GC06P031535
  • GC06P031538
  • GC01M241088
  • GC06P031430
  • GC06Pj31419
  • GC06P031372
  • GC06P031375

Summaries for HCP5 Gene

GeneCards Summary for HCP5 Gene

HCP5 (HLA Complex P5 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with HCP5 include herpes zoster.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCP5 Gene

Genomics for HCP5 Gene

Regulatory Elements for HCP5 Gene

Genomic Location for HCP5 Gene

31,400,702 bp from pter
31,477,506 bp from pter
76,805 bases
Plus strand

Genomic View for HCP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HCP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HCP5 Gene

  • Protein details for HCP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    HLA class I histocompatibility antigen protein P5
    Protein Accession:
    Secondary Accessions:
    • Q04490

    Protein attributes for HCP5 Gene

    132 amino acids
    Molecular mass:
    14098 Da
    Quaternary structure:
    No Data Available
    • HCP5 is localized within the MHC class I region, but is not structurally related to MHC class I genes. HCP5 is related in sequence to human endogenous retroviruses HERV-L and HERV-16. It has sequence homology with retroviral Pol genes in HERV retroviral element; thus, it is itself a good candidate to interact with HIV-1, possibly through an antisense mechanism against retroviral transcript
    • Variation Gly-112 is associated with low viral loads in untreated HIV patients. The level of circulating virus in the plasma of HIV patients (viral set point) varies among individuals during the nonsymptomatic phase preceding the progression to AIDS. This polymorphism explains 9.6% of the total variation in set point and is associated with the HLA-B*5701 allele, which has the strongest described protective impact on HIV disease progression. However, it is possible that HPC5 polymorphism, and not HLA-B*5701 allele, plays a direct role in the control in viremia in HIV patients
    • Sequence=AAA59986.1; Type=Frameshift; Positions=58, 125; Evidence={ECO:0000305};

neXtProt entry for HCP5 Gene

Proteomics data for HCP5 Gene at MOPED

Post-translational modifications for HCP5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HCP5 Gene

Domains & Families for HCP5 Gene

Protein Domains for HCP5 Gene


Suggested Antigen Peptide Sequences for HCP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HCP5: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HCP5 Gene

Function for HCP5 Gene

Phenotypes for HCP5 Gene

GenomeRNAi human phenotypes for HCP5:
genes like me logo Genes that share phenotypes with HCP5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCP5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for HCP5 Gene

Localization for HCP5 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HCP5 Gene

Pathways & Interactions for HCP5 Gene

SuperPathways for HCP5 Gene

No Data Available

Interacting Proteins for HCP5 Gene

Gene Ontology (GO) - Biological Process for HCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 8462994
genes like me logo Genes that share ontologies with HCP5: view

No data available for Pathways by source and SIGNOR curated interactions for HCP5 Gene

Drugs & Compounds for HCP5 Gene

No Compound Related Data Available

Transcripts for HCP5 Gene

Unigene Clusters for HCP5 Gene

HLA complex P5 (non-protein coding):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCP5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCP5 Gene

No ASD Table

Relevant External Links for HCP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HCP5 Gene

mRNA expression in normal human tissues for HCP5 Gene

mRNA differential expression in normal tissues according to GTEx for HCP5 Gene

This gene is overexpressed in Whole Blood (x7.7) and Spleen (x5.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HCP5 Gene

SOURCE GeneReport for Unigene cluster for HCP5 Gene Hs.691948

mRNA Expression by UniProt/SwissProt for HCP5 Gene

Tissue specificity: Expressed in lymphoid tissues; Detected in spleen as well as in B-cell lines, NK cell lines and activated lymphocytes.
genes like me logo Genes that share expression patterns with HCP5: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for HCP5 Gene

Orthologs for HCP5 Gene

Evolution for HCP5 Gene

Gene Tree for HCP5 (if available)
Gene Tree for HCP5 (if available)

No data available for Orthologs for HCP5 Gene

Paralogs for HCP5 Gene

No data available for Paralogs for HCP5 Gene

Variants for HCP5 Gene

Sequence variations from dbSNP and Humsavar for HCP5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_042638 -
VAR_042639 -
VAR_042640 -
VAR_042641 -
VAR_042642 -

Structural Variations from Database of Genomic Variants (DGV) for HCP5 Gene

Variant ID Type Subtype PubMed ID
nsv428140 CNV Gain+Loss 18775914
esv690 CNV CNV 17122850
dgv1042e201 CNV Deletion 23290073
dgv1921e1 CNV Complex 17122850
esv33563 CNV Gain+Loss 17666407
nsv517441 CNV Gain+Loss 19592680
dgv213e55 CNV Gain 17911159
dgv214e55 CNV Gain 17911159
dgv1926e1 CNV Complex 17122850
essv13266 CNV CNV 17122850
esv34063 CNV Loss 18971310
esv26480 CNV Loss 19812545
dgv6571n71 CNV Loss 21882294
dgv747n27 CNV Loss 19166990
dgv1098e199 CNV Deletion 23128226
esv2731822 CNV Deletion 23290073
esv3160 CNV Duplication 18987735
nsv511868 CNV Loss 21212237
nsv513736 CNV Insertion 21212237
esv2432528 CNV Deletion 19546169
nsv435829 CNV Deletion 17901297
nsv10820 CNV Gain+Loss 18304495
dgv6574n71 CNV Gain 21882294
dgv6575n71 CNV Gain+Loss 21882294
nsv823497 CNV Loss 20364138
dgv215e55 CNV Loss 17911159
esv29968 CNV Gain 17803354
nsv441990 CNV CNV 18776908
nsv462854 CNV Gain 19166990
nsv818409 CNV Loss 17921354
esv2752123 CNV Gain 17911159
dgv6576n71 CNV Loss 21882294
dgv6577n71 CNV Loss 21882294
esv34118 CNV Loss 18971310
nsv884405 CNV Loss 21882294
nsv5246 CNV Loss 18451855

Relevant External Links for HCP5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HCP5 Gene

Disorders for HCP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HCP5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
herpes zoster
  • herpes zona
- elite association
Search HCP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HCP5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HCP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HCP5 Gene

Publications for HCP5 Gene

  1. The P5 multicopy gene family in the MHC is related in sequence to human endogenous retroviruses HERV-L and HERV-16. (PMID: 10199916) Kulski J.K. … Dawkins R.L. (Immunogenetics 1999) 2 67
  2. A novel coding sequence belonging to a new multicopy gene family mapping within the human MHC class I region. (PMID: 8462994) Vernet C. … Pontarotti P. (Immunogenetics 1993) 2 67
  3. Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease. (PMID: 24586183) Medici M. … Peeters R.P. (PLoS Genet. 2014) 67
  4. Genetic variation in the HLA region is associated with susceptibility to herpes zoster. (PMID: 25297839) Crosslin D.R. … Jarvik G.P. (Genes Immun. 2014) 67
  5. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein J.I. … Sullivan P.F. (Nat Commun 2014) 67

Products for HCP5 Gene

Sources for HCP5 Gene

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