Aliases for HCN4 Gene
External Ids for HCN4 Gene
Previous GeneCards Identifiers for HCN4 Gene
This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]
GeneCards Summary for HCN4 Gene
HCN4 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4) is a Protein Coding gene. Diseases associated with HCN4 include sick sinus syndrome 2 and brugada syndrome 8. Among its related pathways are cAMP signaling pathway and Transmission across Chemical Synapses. GO annotations related to this gene include identical protein binding and voltage-gated potassium channel activity. An important paralog of this gene is KCNH1.
UniProtKB/Swiss-Prot for HCN4 Gene
Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.