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Aliases for HCN3 Gene

Aliases for HCN3 Gene

  • Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 3 2 3
  • KIAA1535 4 6
  • Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 2

External Ids for HCN3 Gene

Previous GeneCards Identifiers for HCN3 Gene

  • GC01P153105
  • GC01P150988
  • GC01P152025
  • GC01P152464
  • GC01P152060
  • GC01P153513
  • GC01P126609

Summaries for HCN3 Gene

Entrez Gene Summary for HCN3 Gene

  • This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for HCN3 Gene

HCN3 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 3) is a Protein Coding gene. Diseases associated with HCN3 include pallister-hall syndrome and sick sinus syndrome. Among its related pathways are Transmission across Chemical Synapses and Sweet Taste Signaling. GO annotations related to this gene include voltage-gated potassium channel activity and sodium channel activity. An important paralog of this gene is KCNH1.

UniProtKB/Swiss-Prot for HCN3 Gene

  • Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.

Gene Wiki entry for HCN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCN3 Gene

Genomics for HCN3 Gene

Regulatory Elements for HCN3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HCN3 Gene

155,277,427 bp from pter
155,289,848 bp from pter
12,422 bases
Plus strand

Genomic View for HCN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HCN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCN3 Gene

Proteins for HCN3 Gene

  • Protein details for HCN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
    Protein Accession:
    Secondary Accessions:
    • D3DV90
    • Q4VX12
    • Q8N6W6
    • Q9BWQ2

    Protein attributes for HCN3 Gene

    774 amino acids
    Molecular mass:
    86032 Da
    Quaternary structure:
    • Homotetramer. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits (By similarity).
    • Sequence=AAH28024.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HCN3 Gene

Proteomics data for HCN3 Gene at MOPED

Post-translational modifications for HCN3 Gene

  • Glycosylation at Asn291
  • Modification sites at PhosphoSitePlus

Other Protein References for HCN3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HCN3 Gene

Domains for HCN3 Gene

Gene Families for HCN3 Gene

  • CNG :Voltage-gated ion channels / Cyclic nucleotide-regulated channels

Graphical View of Domain Structure for InterPro Entry



  • Q9P1Z3
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position
  • Contains 1 cyclic nucleotide-binding domain.
  • Belongs to the potassium channel HCN family.
genes like me logo Genes that share domains with HCN3: view

Function for HCN3 Gene

Molecular function for HCN3 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Cs(1+) and ZD7288. Is apparently not activated by cAMP.
UniProtKB/Swiss-Prot Function:
Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.

Gene Ontology (GO) - Molecular Function for HCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005248 voltage-gated sodium channel activity IMP 22748890
GO:0005249 voltage-gated potassium channel activity IMP 22748890
GO:0005515 protein binding --
GO:0030552 cAMP binding IEA --
genes like me logo Genes that share ontologies with HCN3: view

Phenotypes for HCN3 Gene

MGI mutant phenotypes for HCN3:
inferred from 1 alleles
GenomeRNAi human phenotypes for HCN3:
genes like me logo Genes that share phenotypes with HCN3: view

Animal Models for HCN3 Gene

MGI Knock Outs for HCN3:

Animal Model Products

miRNA for HCN3 Gene

miRTarBase miRNAs that target HCN3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCN3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HCN3 Gene

Localization for HCN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCN3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for HCN3 Gene COMPARTMENTS Subcellular localization image for HCN3 gene
Compartment Confidence
plasma membrane 4
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with HCN3: view

Pathways for HCN3 Gene

genes like me logo Genes that share pathways with HCN3: view

Pathways by source for HCN3 Gene

1 Qiagen pathway for HCN3 Gene
3 Reactome pathways for HCN3 Gene

Gene Ontology (GO) - Biological Process for HCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0035725 sodium ion transmembrane transport IMP 22748890
GO:0042391 regulation of membrane potential IMP 22748890
genes like me logo Genes that share ontologies with HCN3: view

Compounds for HCN3 Gene

(2) HMDB Compounds for HCN3 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
  • Sodium

(5) IUPHAR Ligand for HCN3 Gene

Ligand Type Action Affinity Pubmed IDs
cilobradine Pore Blocker Antagonist 6
zatebradine Pore Blocker Antagonist 5.7
ivabradine Pore Blocker Antagonist 5.7
ZD7288 Pore Blocker Antagonist 4.7
Cs+ Pore Blocker Antagonist 3.8
genes like me logo Genes that share compounds with HCN3: view

Transcripts for HCN3 Gene

Unigene Clusters for HCN3 Gene

Hyperpolarization activated cyclic nucleotide-gated potassium channel 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCN3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCN3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -
SP3: -
SP4: -

Relevant External Links for HCN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HCN3 Gene

mRNA expression in normal human tissues for HCN3 Gene

mRNA differential expression in normal tissues according to GTEx for HCN3 Gene

This gene is overexpressed in Brain - Cerebellum (5.4) and Brain - Cerebellar Hemisphere (4.8).

Protein differential expression in normal tissues for HCN3 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HCN3 Gene

SOURCE GeneReport for Unigene cluster for HCN3 Gene Hs.706960

mRNA Expression by UniProt/SwissProt for HCN3 Gene

Tissue specificity: Detected in brain.
genes like me logo Genes that share expressions with HCN3: view

Expression partners for HCN3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HCN3 Gene

Orthologs for HCN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HCN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HCN3 35
  • 90.96 (n)
  • 96.38 (a)
HCN3 36
  • 95 (a)
(Canis familiaris)
Mammalia HCN3 35
  • 90.65 (n)
  • 95.35 (a)
HCN3 36
  • 95 (a)
(Mus musculus)
Mammalia Hcn3 35
  • 88.87 (n)
  • 94.83 (a)
Hcn3 16
Hcn3 36
  • 95 (a)
(Pan troglodytes)
Mammalia HCN3 35
  • 94.89 (n)
  • 94.78 (a)
HCN3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hcn3 35
  • 89.09 (n)
  • 94.31 (a)
(Monodelphis domestica)
Mammalia HCN3 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
(Gallus gallus)
Aves HCN3 36
  • 82 (a)
(Danio rerio)
Actinopterygii hcn3 36
  • 62 (a)
HCN3 (2 of 2) 36
  • 84 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002150 35
  • 60.71 (n)
  • 61.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ih 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for HCN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HCN3 Gene

Gene Tree for HCN3 (if available)
Gene Tree for HCN3 (if available)

Paralogs for HCN3 Gene

Selected SIMAP similar genes for HCN3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HCN3: view

Variants for HCN3 Gene

Sequence variations from dbSNP and Humsavar for HCN3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4269766 -- 155,279,117(+) TCCCA(C/G)AGGCC intron-variant
rs7367998 -- 155,281,459(+) tgcct(C/T)ccggg intron-variant
rs7520184 -- 155,283,792(+) AAACT(A/G)CTTTG intron-variant
rs7543234 -- 155,283,517(+) CGTCA(C/T)CTAGC intron-variant
rs7549276 -- 155,278,784(+) CTCCT(A/G)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HCN3 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV Loss 17160897
dgv132e1 CNV Complex 17122850
nsv872457 CNV Loss 21882294
nsv831636 CNV Loss 17160897
esv33869 CNV Loss 17666407
esv23319 CNV Gain 19812545
nsv436027 CNV Insertion 17901297
nsv101 CNV Insertion 15895083
nsv3021 CNV Insertion 18451855
nsv3032 CNV Insertion 18451855
nsv872466 CNV Loss 21882294

Relevant External Links for HCN3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCN3 Gene

Disorders for HCN3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HCN3 Gene in MalaCards »

(2) Diseases for HCN3 Gene including...

(2) University of Copenhagen DISEASES for HCN3 Gene

genes like me logo Genes that share disorders with HCN3: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for HCN3 Gene

Publications for HCN3 Gene

  1. An interactive tool for extracting exons and SNP from genomic sequence: isolation of HCN1 and HCN3 ion channel genes. (PMID: 15290763) Liu Y. … Blevins R. (J Bioinform Comput Biol 2003) 3 23
  2. Endogenous channels in HEK cells and potential roles in HCN ionic current measurements. (PMID: 15979128) Varghese A. … Sigg D.C. (Prog. Biophys. Mol. Biol. 2006) 3 23
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PMID: 16382102) Hofmann F. … Kaupp U.B. (Pharmacol. Rev. 2005) 2 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for HCN3 Gene

Sources for HCN3 Gene

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