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Aliases for HCN3 Gene

Aliases for HCN3 Gene

  • Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 3 2 3 5
  • Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 2
  • KIAA1535 4

External Ids for HCN3 Gene

Previous GeneCards Identifiers for HCN3 Gene

  • GC01P153105
  • GC01P150988
  • GC01P152025
  • GC01P152464
  • GC01P152060
  • GC01P153513
  • GC01P126609

Summaries for HCN3 Gene

Entrez Gene Summary for HCN3 Gene

  • This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for HCN3 Gene

HCN3 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 3) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Potassium Channels. GO annotations related to this gene include ion channel activity and cAMP binding. An important paralog of this gene is KCNH1.

UniProtKB/Swiss-Prot for HCN3 Gene

  • Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.

Gene Wiki entry for HCN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCN3 Gene

Genomics for HCN3 Gene

Regulatory Elements for HCN3 Gene

Promoters for HCN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HCN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HCN3 Gene

Chromosome:
1
Start:
155,277,427 bp from pter
End:
155,289,848 bp from pter
Size:
12,422 bases
Orientation:
Plus strand

Genomic View for HCN3 Gene

Genes around HCN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCN3 Gene

Proteins for HCN3 Gene

  • Protein details for HCN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1Z3-HCN3_HUMAN
    Recommended name:
    Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
    Protein Accession:
    Q9P1Z3
    Secondary Accessions:
    • D3DV90
    • Q4VX12
    • Q8N6W6
    • Q9BWQ2

    Protein attributes for HCN3 Gene

    Size:
    774 amino acids
    Molecular mass:
    86032 Da
    Quaternary structure:
    • Homotetramer. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits (By similarity).
    SequenceCaution:
    • Sequence=AAH28024.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HCN3 Gene

Proteomics data for HCN3 Gene at MOPED

Post-translational modifications for HCN3 Gene

  • Glycosylation at Asn 291
  • Modification sites at PhosphoSitePlus

Other Protein References for HCN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HCN3 Gene

Domains & Families for HCN3 Gene

Gene Families for HCN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P1Z3

UniProtKB/Swiss-Prot:

HCN3_HUMAN :
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Belongs to the potassium channel HCN family.
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Contains 1 cyclic nucleotide-binding domain.
Family:
  • Belongs to the potassium channel HCN family.
genes like me logo Genes that share domains with HCN3: view

Function for HCN3 Gene

Molecular function for HCN3 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Cs(1+) and ZD7288. Is apparently not activated by cAMP.
UniProtKB/Swiss-Prot Function:
Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.

Gene Ontology (GO) - Molecular Function for HCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with HCN3: view
genes like me logo Genes that share phenotypes with HCN3: view

Animal Models for HCN3 Gene

MGI Knock Outs for HCN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for HCN3

miRNA for HCN3 Gene

miRTarBase miRNAs that target HCN3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HCN3 Gene

Localization for HCN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCN3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HCN3 Gene COMPARTMENTS Subcellular localization image for HCN3 gene
Compartment Confidence
plasma membrane 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with HCN3: view

Pathways & Interactions for HCN3 Gene

genes like me logo Genes that share pathways with HCN3: view

Pathways by source for HCN3 Gene

3 Reactome pathways for HCN3 Gene
1 Qiagen pathway for HCN3 Gene

Gene Ontology (GO) - Biological Process for HCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071320 NOT cellular response to cAMP IDA 22748890
GO:0071805 potassium ion transmembrane transport IEA,IMP 22748890
GO:1903351 cellular response to dopamine IEA --
genes like me logo Genes that share ontologies with HCN3: view

No data available for SIGNOR curated interactions for HCN3 Gene

Drugs & Compounds for HCN3 Gene

(6) Drugs for HCN3 Gene - From: HMDB, IUPHAR, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
cilobradine Pharma Antagonist, Pore Blocker 0
Cs<sup>+</sup> Pharma Antagonist, Pore Blocker 0
ivabradine Pharma Antagonist, Pore Blocker 0
zatebradine Pharma Antagonist, Pore Blocker 0

(5) Additional Compounds for HCN3 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
Cesium chloride
7647-17-8
YS-035 hydrochloride
89805-39-0
Zatebradine hydrochloride
91940-87-3
ZD 7288
133059-99-1

(4) Tocris Compounds for HCN3 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0
Zatebradine hydrochloride Blocks hyperpolarization-activated current (If) 91940-87-3
ZD 7288 Inhibits pacemaker (If) current 133059-99-1
genes like me logo Genes that share compounds with HCN3: view

Transcripts for HCN3 Gene

Unigene Clusters for HCN3 Gene

Hyperpolarization activated cyclic nucleotide-gated potassium channel 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HCN3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for HCN3 Gene

GeneLoc Exon Structure for
HCN3
ECgene alternative splicing isoforms for
HCN3

Expression for HCN3 Gene

mRNA expression in normal human tissues for HCN3 Gene

mRNA differential expression in normal tissues according to GTEx for HCN3 Gene

This gene is overexpressed in Brain - Cerebellum (x5.4) and Brain - Cerebellar Hemisphere (x4.8).

Protein differential expression in normal tissues from HIPED for HCN3 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HCN3 Gene



SOURCE GeneReport for Unigene cluster for HCN3 Gene Hs.706960

mRNA Expression by UniProt/SwissProt for HCN3 Gene

Q9P1Z3-HCN3_HUMAN
Tissue specificity: Detected in brain.
genes like me logo Genes that share expression patterns with HCN3: view

Protein tissue co-expression partners for HCN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HCN3 Gene

Orthologs for HCN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HCN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HCN3 35
  • 90.96 (n)
  • 96.38 (a)
HCN3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HCN3 35
  • 90.65 (n)
  • 95.35 (a)
HCN3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hcn3 35
  • 88.87 (n)
  • 94.83 (a)
Hcn3 16
Hcn3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HCN3 35
  • 94.89 (n)
  • 94.78 (a)
HCN3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hcn3 35
  • 89.09 (n)
  • 94.31 (a)
oppossum
(Monodelphis domestica)
Mammalia HCN3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HCN3 36
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hcn3 36
  • 62 (a)
OneToMany
HCN3 (2 of 2) 36
  • 84 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ih 36
  • 25 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002150 35
  • 60.71 (n)
  • 61.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
ManyToMany
Species with no ortholog for HCN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HCN3 Gene

ENSEMBL:
Gene Tree for HCN3 (if available)
TreeFam:
Gene Tree for HCN3 (if available)

Paralogs for HCN3 Gene

(4) SIMAP similar genes for HCN3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HCN3: view

Variants for HCN3 Gene

Sequence variations from dbSNP and Humsavar for HCN3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_048746 -

Structural Variations from Database of Genomic Variants (DGV) for HCN3 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV Loss 17160897
dgv132e1 CNV Complex 17122850
nsv872457 CNV Loss 21882294
nsv831636 CNV Loss 17160897
esv33869 CNV Loss 17666407
esv23319 CNV Gain 19812545
nsv436027 CNV Insertion 17901297
nsv101 CNV Insertion 15895083
nsv3021 CNV Insertion 18451855
nsv3032 CNV Insertion 18451855
nsv872466 CNV Loss 21882294

Variation tolerance for HCN3 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HCN3 Gene

HapMap Linkage Disequilibrium report
HCN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCN3 Gene

Disorders for HCN3 Gene

Relevant External Links for HCN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HCN3

No disorders were found for HCN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HCN3 Gene

Publications for HCN3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Endogenous channels in HEK cells and potential roles in HCN ionic current measurements. (PMID: 15979128) Varghese A. … Sigg D.C. (Prog. Biophys. Mol. Biol. 2006) 3 23
  3. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PMID: 16382102) Hofmann F. … Kaupp U.B. (Pharmacol. Rev. 2005) 2 3
  4. An interactive tool for extracting exons and SNP from genomic sequence: isolation of HCN1 and HCN3 ion channel genes. (PMID: 15290763) Liu Y. … Blevins R. (J Bioinform Comput Biol 2003) 3 23
  5. Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3). (PMID: 23382386) Cao-Ehlker X. … Biel M. (J. Biol. Chem. 2013) 3

Products for HCN3 Gene

Sources for HCN3 Gene

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