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Aliases for HCN3 Gene

Aliases for HCN3 Gene

  • Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 3 2 3 5
  • Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 2
  • KIAA1535 4

External Ids for HCN3 Gene

Previous GeneCards Identifiers for HCN3 Gene

  • GC01P153105
  • GC01P150988
  • GC01P152025
  • GC01P152464
  • GC01P152060
  • GC01P153513
  • GC01P126609

Summaries for HCN3 Gene

Entrez Gene Summary for HCN3 Gene

  • This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for HCN3 Gene

HCN3 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 3) is a Protein Coding gene. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include ion channel activity and cAMP binding. An important paralog of this gene is HCN4.

UniProtKB/Swiss-Prot for HCN3 Gene

  • Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.

Gene Wiki entry for HCN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCN3 Gene

Genomics for HCN3 Gene

Regulatory Elements for HCN3 Gene

Enhancers for HCN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F155316 0.6 ENCODE 38.7 +40.1 40081 2.3 DRAP1 SAP130 ARID4B RAD21 THRB RARA POLR2A HNF4G NR2F6 CREM HCN3 GBA SCAMP3 FAM189B ASH1L MIR555 RNU6-1297P LOC105371451 RUSC1
GH01F155304 0.7 Ensembl ENCODE 33.1 +28.4 28407 2.0 ELF3 DRAP1 KLF1 ZNF792 SAP130 MLX ARID4B DMAP1 YY1 ZNF316 HCN3 GBA KIAA0907 PKLR CLK2
GH01F155276 0.6 ENCODE 32.2 +0.4 385 2.2 ATF1 PKNOX1 ARID4B SIN3A ZNF121 GLIS2 ZNF143 KLF7 KLF13 SP3 HCN3 GBA MUC1 CLK2
GH01F155307 0.7 ENCODE 25.2 +31.7 31674 3.8 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 KIAA0907 LOC101928120 GBA MSTO2P ASH1L-AS1 HCN3 THBS3 ENSG00000271267 DAP3P1 MIR4258
GH01F155222 0.4 ENCODE 19.9 -51.7 -51697 5.9 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 KIAA0907 ENSG00000271267 MSTO2P THBS3 LOC101928120 PYGO2 GBAP1 ASH1L DPM3 RUSC1-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HCN3 on UCSC Golden Path with GeneCards custom track

Promoters for HCN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001750405 373 1601 ATF1 PKNOX1 ARID4B SIN3A ZNF121 GLIS2 ZNF143 KLF7 KLF13 SP3

Genomic Location for HCN3 Gene

Chromosome:
1
Start:
155,277,427 bp from pter
End:
155,289,848 bp from pter
Size:
12,422 bases
Orientation:
Plus strand

Genomic View for HCN3 Gene

Genes around HCN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCN3 Gene

Proteins for HCN3 Gene

  • Protein details for HCN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1Z3-HCN3_HUMAN
    Recommended name:
    Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
    Protein Accession:
    Q9P1Z3
    Secondary Accessions:
    • D3DV90
    • Q4VX12
    • Q8N6W6
    • Q9BWQ2

    Protein attributes for HCN3 Gene

    Size:
    774 amino acids
    Molecular mass:
    86032 Da
    Quaternary structure:
    • Homotetramer. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits (By similarity).
    SequenceCaution:
    • Sequence=AAH28024.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HCN3 Gene

Post-translational modifications for HCN3 Gene

  • Glycosylation at Asn 291
  • Modification sites at PhosphoSitePlus

Other Protein References for HCN3 Gene

Antibody Products

  • Abcam antibodies for HCN3

No data available for DME Specific Peptides for HCN3 Gene

Domains & Families for HCN3 Gene

Gene Families for HCN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P1Z3

UniProtKB/Swiss-Prot:

HCN3_HUMAN :
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Belongs to the potassium channel HCN family.
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Contains 1 cyclic nucleotide-binding domain.
Family:
  • Belongs to the potassium channel HCN family.
genes like me logo Genes that share domains with HCN3: view

Function for HCN3 Gene

Molecular function for HCN3 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Cs(1+) and ZD7288. Is apparently not activated by cAMP.
UniProtKB/Swiss-Prot Function:
Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.

Gene Ontology (GO) - Molecular Function for HCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005248 voltage-gated sodium channel activity IMP 22748890
GO:0005249 voltage-gated potassium channel activity IMP 22748890
GO:0005267 potassium channel activity IEA --
genes like me logo Genes that share ontologies with HCN3: view
genes like me logo Genes that share phenotypes with HCN3: view

Animal Models for HCN3 Gene

MGI Knock Outs for HCN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for HCN3

miRNA for HCN3 Gene

miRTarBase miRNAs that target HCN3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HCN3 Gene

Localization for HCN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCN3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HCN3 Gene COMPARTMENTS Subcellular localization image for HCN3 gene
Compartment Confidence
plasma membrane 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with HCN3: view

Pathways & Interactions for HCN3 Gene

genes like me logo Genes that share pathways with HCN3: view

Pathways by source for HCN3 Gene

3 Reactome pathways for HCN3 Gene
1 Qiagen pathway for HCN3 Gene

Gene Ontology (GO) - Biological Process for HCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with HCN3: view

No data available for SIGNOR curated interactions for HCN3 Gene

Drugs & Compounds for HCN3 Gene

(8) Drugs for HCN3 Gene - From: DGIdb, IUPHAR, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ivabradine Approved Pharma Antagonist, Pore Blocker 0
cyclic amp Experimental Pharma 0
cilobradine Pharma Antagonist, Pore Blocker 0
Cs<sup>+</sup> Pharma Antagonist, Pore Blocker 0
zatebradine Pharma Antagonist, Pore Blocker 0

(1) Additional Compounds for HCN3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5

(2) Tocris Compounds for HCN3 Gene

Compound Action Cas Number
Zatebradine hydrochloride Blocks hyperpolarization-activated current (If) 91940-87-3
ZD 7288 Inhibits pacemaker (If) current 133059-99-1
genes like me logo Genes that share compounds with HCN3: view

Transcripts for HCN3 Gene

Unigene Clusters for HCN3 Gene

Hyperpolarization activated cyclic nucleotide-gated potassium channel 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCN3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for HCN3 Gene

GeneLoc Exon Structure for
HCN3
ECgene alternative splicing isoforms for
HCN3

Expression for HCN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HCN3 Gene

mRNA differential expression in normal tissues according to GTEx for HCN3 Gene

This gene is overexpressed in Brain - Cerebellum (x5.4) and Brain - Cerebellar Hemisphere (x4.8).

Protein differential expression in normal tissues from HIPED for HCN3 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HCN3 Gene



Protein tissue co-expression partners for HCN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HCN3 Gene:

HCN3

SOURCE GeneReport for Unigene cluster for HCN3 Gene:

Hs.706960

mRNA Expression by UniProt/SwissProt for HCN3 Gene:

Q9P1Z3-HCN3_HUMAN
Tissue specificity: Detected in brain.
genes like me logo Genes that share expression patterns with HCN3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HCN3 Gene

Orthologs for HCN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HCN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HCN3 34 35
  • 94.89 (n)
oppossum
(Monodelphis domestica)
Mammalia HCN3 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HCN3 34 35
  • 90.96 (n)
dog
(Canis familiaris)
Mammalia HCN3 34 35
  • 90.65 (n)
rat
(Rattus norvegicus)
Mammalia Hcn3 34
  • 89.09 (n)
mouse
(Mus musculus)
Mammalia Hcn3 34 16 35
  • 88.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HCN3 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii HCN3 (2 of 2) 35
  • 84 (a)
OneToMany
hcn3 35
  • 62 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002150 34
  • 60.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ih 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
ManyToMany
Species where no ortholog for HCN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HCN3 Gene

ENSEMBL:
Gene Tree for HCN3 (if available)
TreeFam:
Gene Tree for HCN3 (if available)

Paralogs for HCN3 Gene

(4) SIMAP similar genes for HCN3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HCN3: view

Variants for HCN3 Gene

Sequence variations from dbSNP and Humsavar for HCN3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35001694 --

Structural Variations from Database of Genomic Variants (DGV) for HCN3 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV loss 17160897
esv23319 CNV gain 19812545
esv2758971 CNV gain 17122850
esv33869 CNV loss 17666407
nsv101 CNV insertion 15895083
nsv3021 CNV insertion 18451855
nsv3032 CNV insertion 18451855
nsv436027 CNV insertion 17901297
nsv831636 CNV loss 17160897
nsv952214 CNV deletion 24416366

Variation tolerance for HCN3 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HCN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HCN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCN3 Gene

Disorders for HCN3 Gene

Relevant External Links for HCN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HCN3

No disorders were found for HCN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HCN3 Gene

Publications for HCN3 Gene

  1. Endogenous channels in HEK cells and potential roles in HCN ionic current measurements. (PMID: 15979128) Varghese A. … Sigg D.C. (Prog. Biophys. Mol. Biol. 2006) 3 22 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PMID: 16382102) Hofmann F. … Kaupp U.B. (Pharmacol. Rev. 2005) 2 3 64
  4. Functional expression of the human HCN3 channel. (PMID: 16043489) Stieber J. … Hofmann F. (J. Biol. Chem. 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for HCN3 Gene

Sources for HCN3 Gene

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