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HCN3 Gene

protein-coding   GIFtS: 58
GCID: GC01P155247

Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium...

  See HCN3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel
31 2
KIAA15353 5
Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated
Channel 32

External Ids:    HGNC: 191831   Entrez Gene: 576572   Ensembl: ENSG000001436307   OMIM: 6099735   UniProtKB: Q9P1Z33   

Export aliases for HCN3 gene to outside databases

Previous GC identifers: GC01P153105 GC01P150988 GC01P152025 GC01P152464 GC01P152060 GC01P153513 GC01P126609


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HCN3 Gene:
This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded
protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for HCN3 Gene:
HCN3 (hyperpolarization activated cyclic nucleotide-gated potassium channel 3) is a protein-coding gene. Diseases associated with HCN3 include sick sinus syndrome, and pallister-hall syndrome. GO annotations related to this gene include sodium channel activity and voltage-gated potassium channel activity. An important paralog of this gene is KCNH6.

UniProtKB/Swiss-Prot: HCN3_HUMAN, Q9P1Z3
Function: Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions

Gene Wiki entry for HCN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HCN3 gene promoter:
         MAZR   POU2F1   p53   POU2F1a   ITF-2   Tal-1beta   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHCN3 promoter sequence
   Search Chromatin IP Primers for HCN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HCN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21.2

HCN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HCN3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155247:  view genomic region     (about GC identifiers)

Start:
155,247,374 bp from pter      End:
155,259,639 bp from pter
Size:
12,266 bases      Orientation:
plus strand

1 alternative location:
Chr1+,NW_003315906 82,606-94,870     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HCN3_HUMAN, Q9P1Z3 (See protein sequence)
Recommended Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3  
Size: 774 amino acids; 86032 Da
Subunit: Homotetramer. The potassium channel is probably composed of a homo- or heterotetrameric complex of
pore-forming subunits (By similarity)
Sequence caution: Sequence=AAH28024.2; Type=Erroneous initiation;
Secondary accessions: D3DV90 Q4VX12 Q8N6W6 Q9BWQ2

Explore the universe of human proteins at neXtProt for HCN3: NX_Q9P1Z3

Explore proteomics data for HCN3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn291
  • Modification sites at PhosphoSitePlus

  • See HCN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065948.1  
    ENSEMBL proteins: 
     ENSP00000357342  
    Reactome Protein details: Q9P1Z3

    HCN3 Human Recombinant Protein Products:

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    antibodies-online peptides for HCN3

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    antibodies-online antibodies for HCN3 (55 products) 

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    antibodies-online kits for HCN3 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CNG: Voltage-gated ion channels / Cyclic nucleotide-regulated channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: HCN3
    Cyclic nucleotide-regulated channels

    Selected InterPro protein domains (see all 6):
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans_dom
     IPR000595 cNMP-bd_dom
     IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
     IPR013621 Ion_trans_N

    Graphical View of Domain Structure for InterPro Entry Q9P1Z3

    ProtoNet protein and cluster: Q9P1Z3

    2 Blocks protein domains:
    IPB000595 Cyclic nucleotide-binding domain
    IPB013621 Ion transport N-terminal


    UniProtKB/Swiss-Prot: HCN3_HUMAN, Q9P1Z3
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel HCN family
    Similarity: Contains 1 cyclic nucleotide-binding domain


    Find genes that share domains with HCN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HCN3_HUMAN, Q9P1Z3
    Function: Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions
    Enzyme regulation: Inhibited by Cs(1+) and ZD7288. Is apparently not activated by cAMP

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005248voltage-gated sodium channel activity IMP--
    GO:0005249voltage-gated potassium channel activity IMP--
    GO:0005272sodium channel activity ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with HCN3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HCN3:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hcn3):
     cardiovascular system  nervous system 

    Find genes that share phenotypes with HCN3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hcn3tm1.1Biel for HCN3

       genOway: Develop your customized and physiologically relevant rodent model for HCN3

    miRNA
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    miRTarBase miRNAs that target HCN3:
    hsa-mir-192-5p (MIRT026503)

    Block miRNA regulation of human, mouse, rat HCN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HCN3 (see all 25):
    hsa-miR-125a-5p hsa-miR-4251 hsa-miR-218 hsa-miR-449a hsa-miR-548m hsa-miR-890 hsa-miR-125b hsa-miR-1286
    SwitchGear 3'UTR luciferase reporter plasmidHCN3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HCN3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HCN3_HUMAN, Q9P1Z3: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IBA--
    GO:0016020membrane ----

    Find genes that share ontologies with HCN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HCN3 About    
    See pathways by source

    SuperPathContained pathways About
    1Sodium channels and transporters inward current
    Sodium channels and transporters inward current
    HCN channels0.00
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Potassium Channels
    Potassium Channels0.43
    4Sweet Taste Signaling
    Sperm Motility0.37
    5Potassium transporters inward current
    Potassium transporters inward current


    Find genes that share SuperPaths with HCN3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HCN3
        Sperm Motility

    1 Reactome Pathway for HCN3
        HCN channels


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HCN3
    Interactions:

        Search GeneGlobe Interaction Network for HCN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for HCN3 (Q9P1Z33 ENSP000003573424) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCN1O607413, ENSP000003073424I2D: score=1 STRING: ENSP00000307342
    HCN4Q9Y3Q43, ENSP000002619174I2D: score=1 STRING: ENSP00000261917
    CAV3ENSP000003419404STRING: ENSP00000341940
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    POLR2FENSP000004038524STRING: ENSP00000403852
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0007268synaptic transmission TAS--
    GO:0035725sodium ion transmembrane transport IMP--
    GO:0042391regulation of membrane potential IMP--
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with HCN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for HCN3

    2 HMDB Compounds for HCN3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    SodiumSodium (see all 2)7440-23-5--

    5 IUPHAR Ligands for HCN3 (HCN3)    About this table
    LigandTypeActionAffinityPubmed IDs
    cilobradine
    Pore BlockerAntagonist616387796
    zatebradine
    Pore BlockerAntagonist5.716387796
    ivabradine
    Pore BlockerAntagonist5.616387796
    ZD7288
    Pore BlockerAntagonist4.716043489
    Cs+
    Pore BlockerAntagonist3.816043489



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HCN3 gene: 
    NM_020897.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368358(uc010pfz.1 uc001fjz.1) ENST00000496230 ENST00000467204
    ENST00000492035
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HCN3 (see all 25):
    hsa-miR-125a-5p hsa-miR-4251 hsa-miR-218 hsa-miR-449a hsa-miR-548m hsa-miR-890 hsa-miR-125b hsa-miR-1286
    SwitchGear 3'UTR luciferase reporter plasmidHCN3 3' UTR sequence
    Inhib. RNA
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    Selected AceView cDNA sequences (see all 47):

    AA384187 BM693435 AW243139 AK055840 BM713434 BQ070889 AB040968 CA428857 
    AA665929 NM_020897 CR625647 BI063704 AL559044 BQ448299 BQ325857 BC028024 
    BE260963 AW001103 BU167626 BI915117 BI918260 AI457329 BE793179 CB265940 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HCN3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
    SP1:                                      -                                                               
    SP2:                                            -                       -                                 
    SP3:        -                                                                                             
    SP4:                                                                    -                                 
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for HCN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HCN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGAGGGAG
    HCN3 Expression
    About this image

    HCN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HCN3 Protein Expression

    UniProtKB/Swiss-Prot: HCN3_HUMAN, Q9P1Z3
    Tissue specificity: Detected in brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HCN3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hcn31 , 5 hyperpolarization-activated, cyclic nucleotide-gated more1, 5 88.87(n)1
    94.83(a)1
      3 (39.01 cM)5
    151681  NM_008227.11  NP_032253.11 
     891460745 
    chicken
    (Gallus gallus)
    Aves HCN36
    hyperpolarization activated cyclic nucleotide-gate...
    82(a)
    1 ↔ 1
    AADN03018895.1(240-1692)
    zebrafish
    (Danio rerio)
    Actinopterygii HCN3 (2 of 2)6
    hcn36
    hyperpolarization activated cyclic nucleotide-gate...
    hyperpolarization activated cyclic nucleotide-gate...
    84(a)
    62(a)
    1 ↔ many
    1 ↔ many
    16(58083121-58086192) ENSDARG00000076615
    19(9808711-9832437) ENSDARG00000027192
    fruit fly
    (Drosophila melanogaster)
    Insecta Ih6
    I[[h]] channel
    25(a)
    1 → many
    2R(10163809-10187349)


    ENSEMBL Gene Tree for HCN3 (if available)
    TreeFam Gene Tree for HCN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HCN3 gene
    KCNH62  KCNH32  KCNH52  HCN42  KCNH42  HCN22  CNGA12  CNGA22  
    HCN12  KCNH22  KCNH72  CNGB12  CNGA42  CNGA32  CNGB32  KCNH82  
    KCNH12  
    4 SIMAP similar genes for HCN3 using alignment to 3 protein entries:     HCN3_HUMAN (see all proteins):
    HCN4    HCN2    HCN1    KCNH2

    Find genes that share paralogs with HCN3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HCN3 (see all 305)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428101511,2
    --155245621(+) AGCTGG/TATGAA 2 -- us2k10--------
    rs360899771,2
    C--155245748(+) TTCCA-/CCTCCTGG 2 -- us2k10--------
    rs1442858891,2
    --155245765(+) TTTTCC/TTAGAT 2 -- us2k10--------
    rs1910416631,2
    --155245926(+) AGCACA/TTTGGG 2 -- us2k10--------
    rs1483328131,2
    --155245936(+) GAAGCC/TAAGGC 2 -- us2k10--------
    rs1823932961,2
    C--155246096(+) CCCTAC/TCTGAG 2 -- us2k10--------
    rs1415120181,2
    --155246310(+) GTCCAA/CATTTT 2 -- us2k10--------
    rs1879583811,2
    --155246501(+) TTAAGA/TGAAAA 2 -- us2k10--------
    rs1924362171,2
    --155246556(+) ATGAAA/GGGGAG 2 -- us2k10--------
    rs559176531,2
    C--155246643(+) CAGTGA/GCTTTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for HCN3 (155247374 - 155259639 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HCN3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3021CNV Insertion18451855
    nsv436027CNV Insertion17901297
    nsv3032CNV Insertion18451855
    nsv101CNV Insertion15895083
    dgv3n68CNV Loss17160897
    nsv872466CNV Loss21882294
    nsv831636CNV Loss17160897
    nsv872457CNV Loss21882294
    esv33869CNV Loss17666407
    esv23319CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HCN3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609973    OMIM disorders: --

    2 diseases for HCN3:    
    About MalaCards
    sick sinus syndrome    pallister-hall syndrome

    2 diseases from the University of Copenhagen DISEASES database for HCN3:
    Pallister-Hall syndrome     Sick sinus syndrome

    Find genes that share disorders with HCN3           About GenesLikeMe


    Export disorders for HCN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HCN3 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with HCN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. Functional expression of the human HCN3 channel. (PubMed id 16043489)1, 2 Stieber J....Hofmann F. (J. Biol. Chem. 2005)
    3. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PubMed id 16382102)1, 3 Hofmann F....Kaupp U.B. (Pharmacol. Rev. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. An interactive tool for extracting exons and SNP from genomic sequence: isolation of HCN1 and HCN3 ion channel genes. (PubMed id 15290763)1, 9 Liu Y....Blevins R. (J Bioinform Comput Biol 2003)
    7. Endogenous channels in HEK cells and potential roles in HCN ionic current measurements. (PubMed id 15979128)1, 9 Varghese A....Sigg D.C. (Prog. Biophys. Mol. Biol. 2006)
    8. Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3). (PubMed id 23382386)1 Cao-Ehlker X....Biel M. (J. Biol. Chem. 2013)
    9. Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases. (PubMed id 21615589)1 Tu E....Semsarian C. (Brain Pathol. 2011)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57657 HGNC: 19183 AceView: HCN3 Ensembl:ENSG00000143630 euGenes: HUgn57657
    ECgene: HCN3 H-InvDB: HCN3

    (According to HUGE)
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    HUGE: KIAA1535

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HCN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HCN3 gene:
    Search GeneIP for patents involving HCN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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