Aliases for HCN2 Gene
External Ids for HCN2 Gene
Previous HGNC Symbols for HCN2 Gene
Previous GeneCards Identifiers for HCN2 Gene
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010]
GeneCards Summary for HCN2 Gene
HCN2 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2) is a Protein Coding gene. Diseases associated with HCN2 include sinoatrial node disease. Among its related pathways are Transmission across Chemical Synapses and cAMP signaling pathway. GO annotations related to this gene include identical protein binding and voltage-gated potassium channel activity. An important paralog of this gene is KCNH1.
UniProtKB/Swiss-Prot for HCN2 Gene
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity).