Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HCN2 Gene

Aliases for HCN2 Gene

  • Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2 2 3 5
  • Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 2 3
  • Brain Cyclic Nucleotide-Gated Channel 2 3 4
  • BCNG-2 3 4
  • BCNG2 3 4
  • Brain Cyclic Nucleotide Gated Channel 2 3
  • HAC-1 3

External Ids for HCN2 Gene

Previous HGNC Symbols for HCN2 Gene

  • BCNG2

Previous GeneCards Identifiers for HCN2 Gene

  • GC19P000641
  • GC19P000529
  • GC19P000540
  • GC19P000359

Summaries for HCN2 Gene

Entrez Gene Summary for HCN2 Gene

  • Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010]

GeneCards Summary for HCN2 Gene

HCN2 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2) is a Protein Coding gene. Diseases associated with HCN2 include Sinoatrial Node Disease. Among its related pathways are cAMP signaling pathway and Potassium Channels. GO annotations related to this gene include identical protein binding and voltage-gated potassium channel activity. An important paralog of this gene is KCNH1.

UniProtKB/Swiss-Prot for HCN2 Gene

  • Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity).

Tocris Summary for HCN2 Gene

Gene Wiki entry for HCN2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCN2 Gene

Genomics for HCN2 Gene

Regulatory Elements for HCN2 Gene

Enhancers for HCN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HCN2 on UCSC Golden Path with GeneCards custom track

Promoters for HCN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HCN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HCN2 Gene

Chromosome:
19
Start:
589,893 bp from pter
End:
617,159 bp from pter
Size:
27,267 bases
Orientation:
Plus strand

Genomic View for HCN2 Gene

Genes around HCN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCN2 Gene

Proteins for HCN2 Gene

  • Protein details for HCN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL51-HCN2_HUMAN
    Recommended name:
    Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
    Protein Accession:
    Q9UL51
    Secondary Accessions:
    • O60742
    • O60743
    • O75267
    • Q9UBS2

    Protein attributes for HCN2 Gene

    Size:
    889 amino acids
    Molecular mass:
    96950 Da
    Quaternary structure:
    • The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. Heterotetramer with HCN1. Forms an obligate 4:4 complex with accessory subunit PEX5L. Interacts with KCNE2 (By similarity). Homotetramer.
    Miscellaneous:
    • Inhibited by extracellular cesium ions.

    Three dimensional structures from OCA and Proteopedia for HCN2 Gene

neXtProt entry for HCN2 Gene

Proteomics data for HCN2 Gene at MOPED

Post-translational modifications for HCN2 Gene

  • Phosphorylation at Ser-668 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating.
  • Ubiquitination at Lys 177
  • Glycosylation at Asn 407
  • Modification sites at PhosphoSitePlus

Other Protein References for HCN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HCN2 (HCN2)
  • Abcam antibodies for HCN2

No data available for DME Specific Peptides for HCN2 Gene

Domains & Families for HCN2 Gene

Gene Families for HCN2 Gene

Suggested Antigen Peptide Sequences for HCN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL51

UniProtKB/Swiss-Prot:

HCN2_HUMAN :
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Belongs to the potassium channel HCN family.
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Contains 1 cyclic nucleotide-binding domain.
Family:
  • Belongs to the potassium channel HCN family.
genes like me logo Genes that share domains with HCN2: view

Function for HCN2 Gene

Molecular function for HCN2 Gene

GENATLAS Biochemistry:
hyperpolarization-activated and cyclic nucleotide gated potassium channel 2,expressed in brain and heart (conduction tissues and contractile myocytes),pace-maker channel of the heart
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. cAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening. Channel activity is modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.
UniProtKB/Swiss-Prot Function:
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity).

Gene Ontology (GO) - Molecular Function for HCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005248 voltage-gated sodium channel activity IMP 22748890
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with HCN2: view
genes like me logo Genes that share phenotypes with HCN2: view

Animal Models for HCN2 Gene

MGI Knock Outs for HCN2:

Animal Model Products

  • Taconic Biosciences Mouse Models for HCN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HCN2 Gene

Localization for HCN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCN2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HCN2 Gene COMPARTMENTS Subcellular localization image for HCN2 gene
Compartment Confidence
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with HCN2: view

Pathways & Interactions for HCN2 Gene

genes like me logo Genes that share pathways with HCN2: view

Pathways by source for HCN2 Gene

1 Cell Signaling Technology pathway for HCN2 Gene
3 Reactome pathways for HCN2 Gene
1 PharmGKB pathway for HCN2 Gene
1 KEGG pathway for HCN2 Gene
1 Qiagen pathway for HCN2 Gene

Gene Ontology (GO) - Biological Process for HCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0007267 cell-cell signaling TAS 9630217
GO:0042391 regulation of membrane potential IEA,IMP 22748890
GO:0060078 regulation of postsynaptic membrane potential IMP 22748890
GO:0071320 cellular response to cAMP IDA 10228147
genes like me logo Genes that share ontologies with HCN2: view

No data available for SIGNOR curated interactions for HCN2 Gene

Drugs & Compounds for HCN2 Gene

(9) Drugs for HCN2 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma Target 0
Cyclic GMP Experimental Pharma Target 0
cilobradine Pharma Antagonist, Pore Blocker 0
Cs<sup>+</sup> Pharma Antagonist, Pore Blocker 0
zatebradine Pharma Antagonist, Pore Blocker 0

(6) Additional Compounds for HCN2 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
sodium
  • Sodium
  • Sodium ion
7440-23-5
Cesium chloride
7647-17-8
YS-035 hydrochloride
89805-39-0
Zatebradine hydrochloride
91940-87-3

(4) Tocris Compounds for HCN2 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0
Zatebradine hydrochloride Blocks hyperpolarization-activated current (If) 91940-87-3
ZD 7288 Inhibits pacemaker (If) current 133059-99-1
genes like me logo Genes that share compounds with HCN2: view

Transcripts for HCN2 Gene

mRNA/cDNA for HCN2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(38) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HCN2 Gene

Hyperpolarization activated cyclic nucleotide-gated potassium channel 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HCN2 Gene

No ASD Table

Relevant External Links for HCN2 Gene

GeneLoc Exon Structure for
HCN2
ECgene alternative splicing isoforms for
HCN2

Expression for HCN2 Gene

mRNA expression in normal human tissues for HCN2 Gene

mRNA differential expression in normal tissues according to GTEx for HCN2 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x6.2), Brain - Spinal cord (cervical c-1) (x5.3), Brain - Caudate (basal ganglia) (x5.0), Brain - Substantia nigra (x4.8), Brain - Cortex (x4.7), and Brain - Nucleus accumbens (basal ganglia) (x4.6).

Protein differential expression in normal tissues from HIPED for HCN2 Gene

This gene is overexpressed in Frontal cortex (26.8), Retina (21.2), Platelet (10.6), and Spinal cord (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HCN2 Gene



SOURCE GeneReport for Unigene cluster for HCN2 Gene Hs.124161

mRNA Expression by UniProt/SwissProt for HCN2 Gene

Q9UL51-HCN2_HUMAN
Tissue specificity: Highly expressed throughout the brain. Detected at low levels in heart.
genes like me logo Genes that share expression patterns with HCN2: view

Protein tissue co-expression partners for HCN2 Gene

- Elite partner

Primer Products

Orthologs for HCN2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HCN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HCN2 35
  • 91.4 (n)
  • 96.73 (a)
HCN2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HCN2 35
  • 93.03 (n)
  • 96.29 (a)
HCN2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hcn2 35
  • 87.39 (n)
  • 93.6 (a)
Hcn2 16
Hcn2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC467640 35
  • 94.4 (n)
  • 91.66 (a)
HCN2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hcn2 35
  • 87.93 (n)
  • 93.83 (a)
oppossum
(Monodelphis domestica)
Mammalia HCN2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HCN2 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves HCN2 35
  • 84.59 (n)
  • 89.97 (a)
HCN2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HCN2 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hcn2 35
  • 76.49 (n)
  • 88.24 (a)
zebrafish
(Danio rerio)
Actinopterygii hcn2b 35
  • 71.32 (n)
  • 78.59 (a)
HCN2 (2 of 2) 36
  • 65 (a)
OneToMany
hcn2b 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ih 37
  • 53 (a)
Ih 36
  • 27 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.20011 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
ManyToMany
Species with no ortholog for HCN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for HCN2 Gene

ENSEMBL:
Gene Tree for HCN2 (if available)
TreeFam:
Gene Tree for HCN2 (if available)

Paralogs for HCN2 Gene

(3) SIMAP similar genes for HCN2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for HCN2 Gene

genes like me logo Genes that share paralogs with HCN2: view

Variants for HCN2 Gene

Sequence variations from dbSNP and Humsavar for HCN2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs55687900 - 610,401(+) CCTGC(A/G)GGAGG reference, missense
rs7256665 -- 590,937(+) AGGGA(A/G)GAGGA intron-variant
rs7257969 -- 596,420(+) AAGGT(C/T)TCCCC intron-variant
rs7258209 -- 603,043(+) GCACC(A/G)GCCTG intron-variant
rs7258226 -- 603,086(+) TGCCC(A/G)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HCN2 Gene

Variant ID Type Subtype PubMed ID
nsv428360 CNV Gain 18775914
nsv910102 CNV Loss 21882294
nsv910109 CNV Loss 21882294
nsv470101 CNV Loss 18288195
nsv910119 CNV Gain 21882294
dgv3508n71 CNV Loss 21882294
dgv3510n71 CNV Loss 21882294
dgv3511n71 CNV Loss 21882294
dgv3512n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3514n71 CNV Gain 21882294
dgv3515n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
dgv3518n71 CNV Loss 21882294
dgv3519n71 CNV Gain+Loss 21882294
nsv910175 CNV Loss 21882294
dgv3525n71 CNV Loss 21882294
dgv3526n71 CNV Loss 21882294
dgv3527n71 CNV Loss 21882294
dgv3528n71 CNV Loss 21882294
nsv910211 CNV Loss 21882294
dgv3529n71 CNV Loss 21882294
esv2658944 CNV Deletion 23128226
dgv3530n71 CNV Gain 21882294
dgv3531n71 CNV Loss 21882294
nsv910224 CNV Loss 21882294
nsv828350 CNV Loss 20364138
dgv523e201 CNV Deletion 23290073
esv2717746 CNV Deletion 23290073
esv1739089 CNV Insertion 17803354
esv2717748 CNV Deletion 23290073
esv2717749 CNV Deletion 23290073
dgv3532n71 CNV Gain 21882294
dgv524e201 CNV Deletion 23290073
esv3037 CNV Deletion 18987735
dgv525e201 CNV Deletion 23290073
dgv3533n71 CNV Gain+Loss 21882294
dgv3534n71 CNV Loss 21882294
nsv910233 CNV Loss 21882294
nsv910235 CNV Loss 21882294
esv27631 CNV Gain 19812545
nsv910238 CNV Loss 21882294
dgv3535n71 CNV Loss 21882294
dgv3536n71 CNV Gain 21882294
dgv3537n71 CNV Loss 21882294

Variation tolerance for HCN2 Gene

Residual Variation Intolerance Score: 2.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.56; 86.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HCN2 Gene

Human Gene Mutation Database (HGMD)
HCN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCN2 Gene

Disorders for HCN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HCN2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sinoatrial node disease
  • sa node
- elite association - COSMIC cancer census association via MalaCards
Search HCN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HCN2

Genetic Association Database (GAD)
HCN2
Human Genome Epidemiology (HuGE) Navigator
HCN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HCN2
genes like me logo Genes that share disorders with HCN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HCN2 Gene

Publications for HCN2 Gene

  1. Identification of a gene encoding a hyperpolarization-activated 'pacemaker' channel of brain. (PMID: 9630217) Santoro B. … Tibbs G.R. (Cell 1998) 2 3 4 67
  2. Augmented currents of an HCN2 variant in patients with febrile seizure syndromes. (PMID: 20437590) Dibbens L.M. … Petrou S. (Ann. Neurol. 2010) 3 23
  3. Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy. (PMID: 17931874) Tang B. … Escayg A. (Neurobiol. Dis. 2008) 3 23
  4. Novel mechanism for suppression of hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by receptor-like tyrosine phosphatase-alpha. (PMID: 18768480) Huang J. … Yu H.G. (J. Biol. Chem. 2008) 3 23
  5. Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels. (PMID: 16777944) Elinder F. … Larsson H.P. (J. Physiol. (Lond.) 2006) 3 23

Products for HCN2 Gene

Sources for HCN2 Gene

Content