Aliases for HCN1 Gene
External Ids for HCN1 Gene
Previous HGNC Symbols for HCN1 Gene
Previous GeneCards Identifiers for HCN1 Gene
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]
GeneCards Summary for HCN1 Gene
HCN1 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1) is a Protein Coding gene. Diseases associated with HCN1 include epileptic encephalopathy, early infantile, 24 and ohtahara syndrome. Among its related pathways are Transmission across Chemical Synapses and Sweet Taste Signaling. GO annotations related to this gene include identical protein binding and voltage-gated potassium channel activity. An important paralog of this gene is KCNH1.
UniProtKB/Swiss-Prot for HCN1 Gene
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.