Aliases for HCN1 Gene
External Ids for HCN1 Gene
Previous HGNC Symbols for HCN1 Gene
Previous GeneCards Identifiers for HCN1 Gene
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]
GeneCards Summary for HCN1 Gene
HCN1 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1) is a Protein Coding gene. Diseases associated with HCN1 include epileptic encephalopathy, early infantile, 24 and undetermined early-onset epileptic encephalopathy. Among its related pathways are Transmission across Chemical Synapses and Potassium Channels. GO annotations related to this gene include identical protein binding and voltage-gated potassium channel activity. An important paralog of this gene is KCNH1.
UniProtKB/Swiss-Prot for HCN1 Gene
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.