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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HCN1 Gene

protein-coding   GIFtS: 60
GCID: GC05M045260

hyperpolarization activated cyclic nucleotide-gated potassium...


(Previous symbol: BCNG1)
 Explore 16 diseases affiliated with
HCN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HCN1    

Aliases
for HCN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 11 2     Brain Cyclic Nucleotide-Gated Channel 12 3
BCNG-11 2 3     Brain Cyclic Nucleotide Gated Channel 12
BCNG11 2 3     Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 12
HAC-21 2     

External Ids:    HGNC: 48451   Entrez Gene: 3489802   Ensembl: ENSG000001645887   OMIM: 6027805   UniProtKB: O607413   

Export aliases for HCN1 gene to outside databases

Previous GC identifers: GC05U990009 GC05M046438 GC05M045262 GC05M045307 GC05M045297


Summaries
for HCN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HCN1:
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the
native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other
pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. (provided by
RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: HCN1_HUMAN, O60741
Function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions.
Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times
higher concentrations, also by cGMP. May mediate responses to sour stimuli

Gene Wiki entry for HCN1


Genomic Views
for HCN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HCN1 gene promoter:
         STAT1   LHX3b/Lhx3b   AML1a   Pax-5   STAT1alpha   AREB6   FOXO4   STAT3   LHX3a/Lhx3a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HCN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HCN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HCN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p12   Ensembl cytogenetic band:  5p12   HGNC cytogenetic band: 5p12

HCN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HCN1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M045260:  view genomic region     (about GC identifiers)

Start:
 45,259,349 bp from pter      End:
 45,696,253 bp from pter
Size:
 436,905 bases      Orientation:
 minus strand

Proteins
for HCN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HCN1_HUMAN, O60741 (See protein sequence)
Recommended Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1  
Size: 890 amino acids; 98796 Da
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits.
Heteromultimer with HCN2 (By similarity). Interacts with KCNE2 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAC39759.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence;

Explore the universe of human proteins at neXtProt for HCN1: NX_O60741

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60741

    • HCN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066550.2  
    ENSEMBL proteins: 
     ENSP00000307342  
    Reactome Protein details: O60741
    Human Recombinant Protein Products: 
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    Uscn Proteins for HCN1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS9405696
    GO:0030424axon IEA--
    GO:0030425dendrite IEA--


    HCN1 for ontologies           About GeneDecksing



    HCN1 Antibody Products: 
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    ThermoFisher Antibodies for HCN1

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    Uscn ELISAs and CLIAs for HCN1

    Protein Domains /
    Families
    for HCN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HCN1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR018488 cNMP-bd_CS
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans_dom
     IPR000595 cNMP-bd_dom
     IPR003938 K_chnl_volt-dep_EAG/ELK/ERG

    Graphical View of Domain Structure for InterPro Entry O60741

    ProtoNet protein and cluster: O60741

    2 Blocks protein families:
    IPB000595 Cyclic nucleotide-binding domain
    IPB013621 Ion transport N-terminal


    UniProtKB/Swiss-Prot: HCN1_HUMAN, O60741
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel HCN family
    Similarity: Contains 1 cyclic nucleotide-binding domain


    Function
    for HCN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HCN1_HUMAN, O60741
    Function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions.
    Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times
    higher concentrations, also by cGMP. May mediate responses to sour stimuli

         Genatlas biochemistry entry for HCN1:
    hyperpolarization-activated and cyclic nucleotide gated potassium channel 1,containing a CCG repeat in 5'utr,related to
    Eag and H-erg,expressed in brain,potentially modulating excitability in the brain and responding to regulation by
    cyclic nucleotides,playing a critical role in shaping the autonomous activity of single neurons and the periodicity of
    network oscillations

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HCN1
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate HCN1 (see all 58):
    hsa-miR-15a hsa-miR-3616-5p hsa-miR-485-3p hsa-miR-200a hsa-let-7a-2* hsa-miR-30d hsa-miR-374c hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmid: HCN1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HCN1 (see all 7)
    OriGene shRNA RFP: HCN1
    Browse OriGene siRNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HCN1

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCN1 

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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005249voltage-gated potassium channel activity IEA--
    GO:0005267potassium channel activity NAS9405696
    GO:0005272sodium channel activity IEA--
    GO:0005515protein binding ----
    GO:0030552cAMP binding IEA--


    HCN1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HCN1:
     Increased cell number in G1, s 

    Animal Models:
         Mouse knock-outs for HCN1: Hcn1tm1.1Lex Hcn1tm2Kndl
         6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Hcn1):
     behavior/neurological  cardiovascular system  integument  nervous system  no phenotypic analysis 
     normal 

    HCN1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HCN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Potassium Channels
    		Potassium Channels1.00
    2HCN channels
    		HCN channels1.00
    3Potassium transporters: inward current
    		Potassium transporters: inward current1.00
    4Sodium channels and transporters: inward current
    		Sodium channels and transporters: inward current1.00
    5Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for HCN1
        Potassium transporters- inward current
    Sodium channels and transporters- inward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HCN1
        Sperm Motility

    3        Reactome Pathways for HCN1
        Potassium Channels
    HCN channels
    Neuronal System



    HCN1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HCN1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for HCN1 (O607413 ENSP000003073424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCN4Q9Y3Q43, ENSP000002619174I2D: score=1 STRING: ENSP00000261917
    HCN2Q9UL513, ENSP000002512874I2D: score=3 STRING: ENSP00000251287
    HCN3Q9P1Z33, ENSP000003573424I2D: score=1 STRING: ENSP00000357342
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport NAS9405696
    GO:0007268synaptic transmission TAS--
    GO:0045176apical protein localization IEA--
    GO:0046549retinal cone cell development IEA--
    GO:0071805potassium ion transmembrane transport ----


    HCN1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HCN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HCN1

    2 HMDB Compounds for HCN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    SodiumSodium (see all 2)7440-23-5--
    Search CenterWatch for drugs/clinical trials and news about HCN1 

    Transcripts
    for HCN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HCN1 gene: 
    NM_021072.3  

    Unigene Cluster for HCN1:

    Hyperpolarization activated cyclic nucleotide-gated potassium channel 1
    Hs.353176  [show with all ESTs]
    Unigene Representative Sequence: NM_021072
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303230(uc003jok.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HCN1
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate HCN1 (see all 58):
    hsa-miR-15a hsa-miR-3616-5p hsa-miR-485-3p hsa-miR-200a hsa-let-7a-2* hsa-miR-30d hsa-miR-374c hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmid: HCN1 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: HCN1 (NM_021072)
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    Primer
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    Additional cDNA sequence: 

    AF064876.1 AF488549.1 AK094523.1 BX537747.1 

    3 DOTS entries:

    DT.40229330  DT.208390  DT.97804453 

    24 AceView cDNA sequences:

    BM682352 BM674287 BM675680 BQ186189 BQ184730 AK094523 CR601376 BM717819 
    BM931647 BX509817 AF064876 AF488549 BX955363 BX395019 AW054787 NM_021072 
    BX490817 BV182724 BX537747 BF671513 BM715980 H45591 R51256 R51255 

    GeneLoc Exon Structure


    Expression
    for HCN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HCN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCTTTCAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HCN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HCN1

    SOURCE GeneReport for Unigene cluster: Hs.353176

    UniProtKB/Swiss-Prot: HCN1_HUMAN, O60741
    Tissue specificity: Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus,
    corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very
    low levels in muscle and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including HCN1: 
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    In Situ
    Assay Products:     
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    Orthologs
    for HCN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HCN1 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hcn11 , 5 hyperpolarization-activated, cyclic nucleotide-gated more1, 5 89.51(n)1
    96.69(a)1    		   13 (66.34 cM)5
    151651  NM_010408.31  NP_034538.21 
     1176024805 
    chicken
    (Gallus gallus)    		 Aves HCN11 hyperpolarization activated cyclic nucleotide-gated more 82.88(n)
    91.22(a)    		   431590  XM_429145.3  XP_429145.3 
    lizard
    (Anolis carolinensis)    		 Reptilia HCN16
    		 --
    		 85(a)
    		 1 ↔ 1
    		 2(5088367-5332446)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003342971 potassium/sodium hyperpolarization-activated cyclic more 74.31(n)
    88.18(a)    		   100334297  XM_002663874.2  XP_002663920.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ih6
    		 I[[h]] channel
    		 24(a)
    		 1 → many
    		 2R(10163809-10187349)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SPIK6
    ATCNGC76
    (see all 29)    		 cyclic nucleotide gated channel 7
    (see all 29)    		 9(a)
    14(a)
    (see all 29)    		 possible ortholog
    possible ortholog
    (see all 29)    		 2(10894486-10898642)
    1(5491304-5493772)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 28)    		 potassium channel KAT1, putative, expressed
    (see all 28)    		 20(a)
    18(a)
    (see all 28)    		 possible ortholog
    possible ortholog
    (see all 28)    		 6(19563212-19568252)
    1(31760179-31762843)


    ENSEMBL Gene Tree for HCN1 (if available)
    TreeFam Gene Tree for HCN1 (if available) 

    Paralogs
    for HCN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HCN1 gene
    KCNH62  KCNH32  KCNH52  HCN32  HCN42  HCN22  KCNH42  CNGA22  
    CNGA12  KCNH72  KCNH22  CNGB12  CNGA42  CNGA32  CNGB32  KCNH12  
    KCNH82  
    4 SIMAP similar genes for HCN1 using alignment to 2 protein entries:     HCN1_HUMAN (see all proteins):
    HCN2    HCN3    HCN4    KCNH2

    HCN1 for paralogs           About GeneDecksing



    Genomic Variants
    for HCN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6243 NCBI SNPs in HCN1 are shown (see all 6243)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1884244681,2
    		--45254638(+) AGCCAA/GTCGCA 1 -- ds50010--------
    rs1473291761,2
    		--45254641(+) CAATCA/GCAGGG 1 -- ds50010--------
    rs1487884861,2
    		--45254692(+) ATGGGA/TGGGGA 1 -- ds50010--------
    rs1425234371,2
    		--45254720(+) GCTGGC/TCACCC 1 -- ds50010--------
    rs1154345151,2
    		F,--45254727(+) ACCCCC/AAAGCC 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1916531611,2
    		--45254731(+) CCAAGA/CCAGCA 1 -- ds50010--------
    rs1505048771,2
    		--45254746(+) CATCCC/TACTGG 1 -- ds50010--------
    rs1395372731,2
    		--45254838(+) AACACC/GGCAAA 1 -- ds50010--------
    rs1166660321,2
    		F,--45254839(+) ACACCG/ACAAAG 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1839902451,2
    		--45254848(+) AGGTCC/TGTGGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HCN1 (45259349 - 45509349 bp, first 250kb of HCN1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 19 variations for HCN1
         1 CNV: 99123
         15/18 Indels (see all 18): 99124 12680 46890 93020 80901 93022 80902 80899 80904 12681 93021 80903 93023 93024 80900
    Human Gene Mutation Database (HGMD): HCN1

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for HCN1

    Disorders / Diseases
    for HCN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HCN1 for disorders           About GeneDecksing

    OMIM gene information: 602780    OMIM disorders: --

    16 diseases for HCN1:    About MalaCards
    gilles de la tourette syndrome    attention deficit hyperactivity disorder    idiopathic generalized epilepsy    generalized epilepsy
    status epilepticus    corpus callosum    tourette syndrome    breast cancer susceptibility
    fanconi's anemia    neuronitis    breast cancer    aldosteronism
    anemia    sinusitis    seizures    retinitis

    1 Novoseek disease relationship for HCN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epilepsy 23.3 1 18070091 (1)

    Human Genome Epidemiology (HuGE) Navigator: HCN1 (5 documents)

    Export disorders for HCN1 gene to outside databases

    Publications
    for HCN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HCN1 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with HCN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a gene encoding a hyperpolarization-activated 'pacemaker' channel of brain. (PubMed id 9630217)1, 2, 3 Santoro B.... Tibbs G.R. (1998)
    2. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PubMed id 16382102)1, 3 Hofmann F....Kaupp U.B. (2005)
    3. Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. (PubMed id 9405696)1, 3 Santoro B....Kandel E.R. (1997)
    4. Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. (PubMed id 12890777)1, 9 Bender R.A....Baram T.Z. (2003)
    5. Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy. (PubMed id 17931874)1, 9 Tang B....Escayg A. (2008)
    6. Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder. (PubMed id 18081024)1, 9 Laurin N....Barr C.L. (2008)
    7. TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels. (PubMed id 23077068)1 Huang Z....Shah M.M. (2012)
    8. Hyperpolarization-activated cation current contributes to spontaneous network activity in developing neocortical cultures. (PubMed id 22094222)1 Klueva J....Munsch T. (2012)
    9. Genetic analysis of hyperpolarization-activated cycli c nucleotide-gated cation channels in sudden unexpected death in epilepsy cases . (PubMed id 21615589)1 Tu E....Semsarian C. (2011)
    10. Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricop eptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at d istinct sites. (PubMed id 21504900)1 Han Y....Chetkovich D.M. (2011)

    External Searches for HCN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HCN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 348980 HGNC: 4845 AceView: HCN1 Ensembl:ENSG00000164588 euGenes: HUgn348980
    ECgene: HCN1 H-InvDB: HCN1

    Other Databases showing HCN1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HCN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HCN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HCN1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for HCN1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HCN1 gene:
    Search GeneIP for patents involving HCN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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