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Aliases for HCLS1 Gene

Aliases for HCLS1 Gene

  • Hematopoietic Cell-Specific Lyn Substrate 1 2 3
  • LckBP1 3 4
  • P75 3 4
  • HS1 3 4
  • Hematopoietic Lineage Cell-Specific Protein 3
  • Hematopoietic Cell-Specific LYN Substrate 1 4
  • Cortactin-Like 2
  • CTTNL 3

External Ids for HCLS1 Gene

Previous GeneCards Identifiers for HCLS1 Gene

  • GC03U990043
  • GC03M120991
  • GC03M122631
  • GC03M122671
  • GC03M122832
  • GC03M121350
  • GC03M118724

Summaries for HCLS1 Gene

GeneCards Summary for HCLS1 Gene

HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1) is a Protein Coding gene. Diseases associated with HCLS1 include chronic lymphocytic leukemia. Among its related pathways are Proteoglycans in cancer and B Cell Receptor Signaling Pathway (WikiPathways). GO annotations related to this gene include protein kinase binding and protein complex binding. An important paralog of this gene is DBN1.

UniProtKB/Swiss-Prot for HCLS1 Gene

  • Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression

Gene Wiki entry for HCLS1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCLS1 Gene

Genomics for HCLS1 Gene

Regulatory Elements for HCLS1 Gene

Genomic Location for HCLS1 Gene

Start:
121,631,399 bp from pter
End:
121,660,944 bp from pter
Size:
29,546 bases
Orientation:
Minus strand

Genomic View for HCLS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HCLS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCLS1 Gene

Proteins for HCLS1 Gene

  • Protein details for HCLS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14317-HCLS1_HUMAN
    Recommended name:
    Hematopoietic lineage cell-specific protein
    Protein Accession:
    P14317
    Secondary Accessions:
    • B4DQ69
    • Q53Y93
    • Q6IBK9
    • Q9UDK0

    Protein attributes for HCLS1 Gene

    Size:
    486 amino acids
    Molecular mass:
    54014 Da
    Quaternary structure:
    • Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. Interacts with FES/FPS (By similarity). Interacts (via SH2 domain) with FGR. Forms a multiprotein complex with LYN and ANKRD54 (By similarity).

    Alternative splice isoforms for HCLS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HCLS1 Gene

Proteomics data for HCLS1 Gene at MOPED

Post-translational modifications for HCLS1 Gene

  • Phosphorylated by FES (By similarity). Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HCLS1 Gene

Antibody Products

No data available for DME Specific Peptides for HCLS1 Gene

Domains for HCLS1 Gene

Protein Domains for HCLS1 Gene

Suggested Antigen Peptide Sequences for HCLS1 Gene

Graphical View of Domain Structure for InterPro Entry

P14317

UniProtKB/Swiss-Prot:

HCLS1_HUMAN :
  • P14317
Domain:
  • Contains 1 SH3 domain.
Similarity:
  • Contains 4 cortactin repeats.
genes like me logo Genes that share domains with HCLS1: view

No data available for Gene Families for HCLS1 Gene

Function for HCLS1 Gene

Molecular function for HCLS1 Gene

GENATLAS Biochemistry:
hematopoietic cell-specific Lyn substrate 1,75kDa,involved in signal transduction
UniProtKB/Swiss-Prot Function:
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression

Gene Ontology (GO) - Molecular Function for HCLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IPI 23001182
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0017124 SH3 domain binding IEA --
GO:0019901 protein kinase binding IPI 23001182
genes like me logo Genes that share ontologies with HCLS1: view

Phenotypes for HCLS1 Gene

genes like me logo Genes that share phenotypes with HCLS1: view

Animal Models for HCLS1 Gene

MGI Knock Outs for HCLS1:

Animal Model Products

miRNA for HCLS1 Gene

miRTarBase miRNAs that target HCLS1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCLS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HCLS1 Gene

Localization for HCLS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCLS1 Gene

Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HCLS1 Gene COMPARTMENTS Subcellular localization image for HCLS1 gene
Compartment Confidence
mitochondrion 4
nucleus 4
plasma membrane 4
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for HCLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005667 transcription factor complex IDA 23001182
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with HCLS1: view

Pathways for HCLS1 Gene

genes like me logo Genes that share pathways with HCLS1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HCLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 2587259
GO:0008284 positive regulation of cell proliferation ISS --
GO:0009725 response to hormone ISS --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP 23001182
genes like me logo Genes that share ontologies with HCLS1: view

Compounds for HCLS1 Gene

(3) Novoseek inferred chemical compound relationships for HCLS1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 68.1 42
ceramide 38 4
calcium 0 4
genes like me logo Genes that share compounds with HCLS1: view

Transcripts for HCLS1 Gene

Unigene Clusters for HCLS1 Gene

Hematopoietic cell-specific Lyn substrate 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCLS1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCLS1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - -
SP4: -
SP5: - - - -
SP6: - - -
SP7: -
SP8:
SP9:

ExUns: 14b ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for HCLS1 Gene

GeneLoc Exon Structure for
HCLS1
ECgene alternative splicing isoforms for
HCLS1

Expression for HCLS1 Gene

mRNA expression in normal human tissues for HCLS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HCLS1 Gene

This gene is overexpressed in Whole Blood (25.1) and Spleen (5.6).

Protein differential expression in normal tissues for HCLS1 Gene

This gene is overexpressed in Lymph node (28.4) and Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HCLS1 Gene

SOURCE GeneReport for Unigene cluster for HCLS1 Gene Hs.14601

mRNA Expression by UniProt/SwissProt for HCLS1 Gene

P14317-HCLS1_HUMAN
Tissue specificity: Expressed only in tissues and cells of hematopoietic origin
genes like me logo Genes that share expressions with HCLS1: view

Expression partners for HCLS1 Gene

In Situ Assay Products

Orthologs for HCLS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HCLS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HCLS1 35
  • 89.12 (n)
  • 89.6 (a)
HCLS1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HCLS1 35
  • 86.85 (n)
  • 86.01 (a)
HCLS1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hcls1 35
  • 86.2 (n)
  • 85.71 (a)
Hcls1 16
Hcls1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HCLS1 35
  • 99.17 (n)
  • 98.55 (a)
HCLS1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hcls1 35
  • 86.09 (n)
  • 87.5 (a)
oppossum
(Monodelphis domestica)
Mammalia HCLS1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HCLS1 36
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves HCLS1 35
  • 65.87 (n)
  • 61.34 (a)
HCLS1 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HCLS1 36
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hcls1 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cortactin 37
  • 46 (a)
Cortactin 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7160 36
  • 39 (a)
OneToOne
Species with no ortholog for HCLS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HCLS1 Gene

ENSEMBL:
Gene Tree for HCLS1 (if available)
TreeFam:
Gene Tree for HCLS1 (if available)

Paralogs for HCLS1 Gene

Paralogs for HCLS1 Gene

Selected SIMAP similar genes for HCLS1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HCLS1: view

Variants for HCLS1 Gene

Sequence variations from dbSNP and Humsavar for HCLS1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs765829 -- 121,654,127(-) ccata(A/G)gttgc intron-variant
rs1128154 -- 121,631,769(-) TCCTG(A/C)TGCAA utr-variant-3-prime
rs1128158 -- 121,631,746(-) ATGAG(G/T)TTCTG utr-variant-3-prime
rs1128159 -- 121,631,736(-) GGACA(A/C/G)ACTTC utr-variant-3-prime
rs1128163 -- 121,631,726(-) CCCTC(A/C/T)CCTGC utr-variant-3-prime

Relevant External Links for HCLS1 Gene

HapMap Linkage Disequilibrium report
HCLS1
Human Gene Mutation Database (HGMD)
HCLS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HCLS1 Gene

Disorders for HCLS1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HCLS1 Gene in MalaCards »

(1) Diseases for HCLS1 Gene including...

(4) Novoseek inferred disease relationships for HCLS1 Gene

Disease -log(P) Hits PubMed IDs
glioma 0 2
tumors 0 8
lymphoma 0 2
melanoma 0 1

Relevant External Links for HCLS1

Genetic Association Database (GAD)
HCLS1
Human Genome Epidemiology (HuGE) Navigator
HCLS1
genes like me logo Genes that share disorders with HCLS1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for HCLS1 Gene

Publications for HCLS1 Gene

  1. The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization. (PMID: 8978766) Egashira M. … Niikawa N. (Cytogenet. Cell Genet. 1996) 2 3 23
  2. Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase. (PMID: 10066823) Brunati A.M. … Pinna L.A. (J. Biol. Chem. 1999) 3 4 23
  3. Identification of HS1 protein as a major substrate of protein- tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling. (PMID: 7682714) Yamanashi Y. … Yamamoto T. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 23
  4. Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis. (PMID: 15022330) Otsuka J. … Harada M. (Arthritis Rheum. 2004) 3 23 48
  5. Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain. (PMID: 15710041) van Rossum A.G. … Schuuring E. (BMC Genomics 2005) 2 3 23

Products for HCLS1 Gene

Sources for HCLS1 Gene

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