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HCLS1 Gene

protein-coding   GIFtS: 66
GCID: GC03M121350

Hematopoietic Cell-Specific Lyn Substrate 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hematopoietic Cell-Specific Lyn Substrate 11 2 3     CTTNL2
HS12 3     Hematopoietic Lineage Cell-Specific Protein2
p752 3     lckBP12
cortactin-like1     LckBP13

External Ids:    HGNC: 48441   Entrez Gene: 30592   Ensembl: ENSG000001803537   OMIM: 6013065   UniProtKB: P143173   

Export aliases for HCLS1 gene to outside databases

Previous GC identifers: GC03U990043 GC03M120991 GC03M122631 GC03M122671 GC03M122832 GC03M118724


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HCLS1 Gene:
HCLS1 (hematopoietic cell-specific Lyn substrate 1) is a protein-coding gene. GO annotations related to this gene include protein kinase binding and protein complex binding. An important paralog of this gene is DBN1.

UniProtKB/Swiss-Prot: HCLS1_HUMAN, P14317
Function: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling
for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene
expression

Gene Wiki entry for HCLS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the HCLS1 gene promoter:
         Sox5   AML1a   YY1   MZF-1   Pax-3   POU2F1   FOXJ2 (long isoform)   FOXO4   POU2F1a   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHCLS1 promoter sequence
   Search Chromatin IP Primers for HCLS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HCLS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q13

HCLS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HCLS1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M121350:  view genomic region     (about GC identifiers)

Start:
121,350,246 bp from pter      End:
121,379,791 bp from pter
Size:
29,546 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HCLS1_HUMAN, P14317 (See protein sequence)
Recommended Name: Hematopoietic lineage cell-specific protein  
Size: 486 amino acids; 54014 Da
Subunit: Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while
binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN,
but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not
associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region.
Interacts with HS1BP3. Interacts with FES/FPS (By similarity). Interacts (via SH2 domain) with FGR. Forms a
multiprotein complex with LYN and ANKRD54 (By similarity)
Developmental stage: Expressed in early stage of myeloid and erythroid differentiation
Secondary accessions: Q53Y93 Q6IBK9 Q9UDK0

Explore the universe of human proteins at neXtProt for HCLS1: NX_P14317

Explore proteomics data for HCLS1 at MOPED

Post-translational modifications: 

  • Phosphorylated by FES (By similarity). Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on
    B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HCLS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005326.2  
    ENSEMBL proteins: 
     ENSP00000320176   ENSP00000387645   ENSP00000418299   ENSP00000420507   ENSP00000419614  

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    Cloud-Clone Corp. Proteins for HCLS1

     
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    Cloud-Clone Corp. ELISAs for HCLS1
    Cloud-Clone Corp. CLIAs for HCLS1
    Search eBioscience for ELISAs for HCLS1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR003134 Hs1_Cortactin
     IPR001452 SH3_domain
     IPR028534 HS1

    Graphical View of Domain Structure for InterPro Entry P14317

    ProtoNet protein and cluster: P14317

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB003134 Hs1/Cortactin


    UniProtKB/Swiss-Prot: HCLS1_HUMAN, P14317
    Similarity: Contains 4 cortactin repeats
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with HCLS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HCLS1_HUMAN, P14317
    Function: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling
    for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene
    expression

         Genatlas biochemistry entry for HCLS1:
    hematopoietic cell-specific Lyn substrate 1,75kDa,involved in signal transduction

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001085RNA polymerase II transcription factor binding IPI--
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI--
    GO:0017124SH3 domain binding IEA--
    GO:0019901protein kinase binding IPI--
         
    Find genes that share ontologies with HCLS1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HCLS1:
     Decreased TP53 protein express 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hcls1):
     hematopoietic system  immune system 

    Find genes that share phenotypes with HCLS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HCLS1: Hcls1tm2Wtn Hcls1tm1Wtn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HCLS1
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    miRNA
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    miRTarBase miRNAs that target HCLS1:
    hsa-mir-484 (MIRT041795)

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    3 qRT-PCR Assays for microRNAs that regulate HCLS1:
    hsa-miR-3117-3p hsa-miR-650 hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidHCLS1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HCLS1_HUMAN, P14317: Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    nucleus4
    plasma membrane4
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005667transcription factor complex IDA--
    GO:0005737cytoplasm ISS--
    GO:0005739mitochondrion IEA--
    GO:0005886plasma membrane ----

    Find genes that share ontologies with HCLS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HCLS1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Pathogenic Escherichia coli infection0.43
    Pathogenic Escherichia coli infection0.41
    2Immune response Fc epsilon RI pathway
    Fc-epsilon receptor I signaling in mast cells0.34
    3Salmonella infection (KEGG)
    Shigellosis0.30
    4Tight junction
    Tight junction
    5Proteoglycans in cancer
    Proteoglycans in cancer


    Find genes that share SuperPaths with HCLS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HCLS1
        Lymphocyte Signaling

    4 BioSystems Pathways for HCLS1
        IL-5 Signaling Pathway
    B Cell Receptor Signaling Pathway
    Pathogenic Escherichia coli infection
    Fc-epsilon receptor I signaling in mast cells



    5 Kegg Pathways  (Kegg details for HCLS1):
        Tight junction
    Bacterial invasion of epithelial cells
    Pathogenic Escherichia coli infection
    Shigellosis
    Proteoglycans in cancer

        Pathway & Disease-focused RT2 Profiler PCR Array including HCLS1: 
              Tight Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HCLS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HCLS1 (P143171, 2, 3 ENSP000003201764) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LYNP079482, 3MINT-61343 MINT-8026812 I2D: score=7 
    SH2D4AQ9H7882, 3, ENSP000002658074MINT-67768 I2D: score=5 STRING: ENSP00000265807
    QKIQ96PU82, 3, ENSP000003549514MINT-2859489 I2D: score=3 STRING: ENSP00000354951
    HAX1O001653, ENSP000003290024I2D: score=4 STRING: ENSP00000329002
    CASP3P425743, ENSP000003110324I2D: score=3 STRING: ENSP00000311032
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006355regulation of transcription, DNA-templated TAS2587259
    GO:0008284positive regulation of cell proliferation ISS--
    GO:0009725response to hormone ISS--
    GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling IMP--

    Find genes that share ontologies with HCLS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HCLS1

    3 Novoseek inferred chemical compound relationships for HCLS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 68.1 48 9794375 (4), 10825163 (4), 9104825 (3), 7927516 (3) (see all 28)
    ceramide 38 6 17437539 (2), 16763091 (1), 8580709 (1)
    calcium 0 5 19917685 (2), 8626395 (2)



    Find genes that share compounds with HCLS1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HCLS1 gene: 
    NM_005335.4  

    Unigene Cluster for HCLS1:

    Hematopoietic cell-specific Lyn substrate 1
    Hs.14601  [show with all ESTs]
    Unigene Representative Sequence: AK124015
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314583(uc003eeh.4 uc011bjj.2 uc011bjk.1) ENST00000473883
    ENST00000428394 ENST00000495491 ENST00000464274 ENST00000487290(uc011bjl.1)
    ENST00000481314 ENST00000497391 ENST00000488033 ENST00000468693 ENST00000491824
    ENST00000479994
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidHCLS1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HCLS1
      QuantiFast Probe-based Assays in human, mouse, rat HCLS1

    Additional mRNA sequence: 

    AK124015.1 AK225633.1 AK298663.1 AK298696.1 AK300301.1 AK312750.1 BC016758.2 BT006824.1 
    CR456794.1 X16663.1 

    17 DOTS entries:

    DT.314851  DT.100675378  DT.120878283  DT.100813126  DT.100813127  DT.120878262  DT.429637  DT.100813132 
    DT.120878277  DT.120878271  DT.86855177  DT.97854039  DT.100813123  DT.120878261  DT.120878294  DT.95349977 
    DT.91891464 

    Selected AceView cDNA sequences (see all 200):

    BQ004241 AA720908 CA447092 BQ016369 AW512741 AA361444 BU688141 AA419431 
    AW402869 BQ706466 BQ008940 CB152116 BP338037 BQ005411 CA308295 BG388342 
    AI332878 CB306834 BX448930 BG398548 BI035828 AA256040 BX452718 BU162810 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HCLS1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
    SP1:                                            -     -     -     -                             -     -                 -                                       
    SP2:                                -     -     -     -     -     -     -     -                 -     -                 -                                       
    SP3:                                                                                            -     -           -     -                                       
    SP4:                                                                                                                    -                                       
    SP5:                                            -     -     -     -                                                                                             

    ExUns: 14b ^ 15
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for HCLS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HCLS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACATTTCTC
    HCLS1 Expression
    About this image


    HCLS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             Thymus
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Tonsil (Hematopoietic System)
    HCLS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HCLS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.14601

    UniProtKB/Swiss-Prot: HCLS1_HUMAN, P14317
    Tissue specificity: Expressed only in tissues and cells of hematopoietic origin

        Pathway & Disease-focused RT2 Profiler PCR Array including HCLS1: 
              Tight Junctions in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCLS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HCLS1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hcls11 , 5 hematopoietic cell specific Lyn substrate 11, 5 86.2(n)1
    85.71(a)1
      16 (26.30 cM)5
    151631  NM_008225.21  NP_032251.21 
     369349835 
    chicken
    (Gallus gallus)
    Aves HCLS11 hematopoietic cell-specific Lyn substrate 1 65.87(n)
    61.34(a)
      426867  NM_001031401.1  NP_001026572.1 
    lizard
    (Anolis carolinensis)
    Reptilia HCLS16
    hematopoietic cell-specific Lyn substrate 1
    41(a)
    1 ↔ 1
    GL344286.1(11339-52314)
    zebrafish
    (Danio rerio)
    Actinopterygii hcls16
    hematopoietic cell-specific Lyn substrate 1
    46(a)
    1 ↔ 1
    4(21236017-21247351) ENSDARG00000012729
    fruit fly
    (Drosophila melanogaster)
    Insecta Cortactin3 cytoskeleton organization and
    biogenesis structural more
    46(a)     --


    ENSEMBL Gene Tree for HCLS1 (if available)
    TreeFam Gene Tree for HCLS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HCLS1 gene
    DBN12  DBNL2  CTTN2  
    6 SIMAP similar genes for HCLS1 using alignment to 5 protein entries:     HCLS1_HUMAN (see all proteins):
    EMS1    CTTN    SH3GL2    SH3GL1    ARHGEF7    DBNL

    Find genes that share paralogs with HCLS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HCLS1 (see all 730)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1923075061,2
    --121349832(+) ACTTTA/GGGAGG 1 -- int10--------
    rs1440600431,2
    --121349850(+) GGGGGC/TGATCA 1 -- int10--------
    rs64386441,2
    C,A,H--121349976(+) aggctA/Gaggca 1 -- int13Minor allele frequency- G:0.20NA CSA 5
    rs1410272611,2
    C--121350126(+) TCTAGA/GGTACA 1 -- int10--------
    rs1448411581,2
    --121350211(+) GGCCAC/TGAGGG 1 -- int10--------
    rs717668801,2
    C--121350305(+) GGTTC-/CAAGATA 1 -- ut310--------
    rs770607511,2
    C--121350447(+) GAGGTG/ATTCAT 1 -- ut312Minor allele frequency- A:0.06WA 120
    rs412714071,2
    C--121350451(+) TGTTCA/CTTGGG 1 -- ut314Minor allele frequency- C:0.10CSA WA NA EA 360
    rs777763991,2
    C,F--121350458(+) TGGGAA/GGGAGT 1 -- ut312Minor allele frequency- G:0.02NA EA 240
    rs67791021,2
    C,H--121350563(+) CCTTAA/GTGAAG 1 -- ut314Minor allele frequency- G:0.00NS EA 418

    HapMap Linkage Disequilibrium report for HCLS1 (121350246 - 121379791 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HCLS1: --
    Human Gene Mutation Database (HGMD): HCLS1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HCLS1
    DNA2.0 Custom Variant and Variant Library Synthesis for HCLS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601306    OMIM disorders: --


    Find genes that share disorders with HCLS1           About GenesLikeMe

    4 Novoseek inferred disease relationships for HCLS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 0 1 16763091 (1), 17651887 (1)
    tumors 0 9 15084380 (2), 9309140 (2), 10882332 (1), 11420455 (1) (see all 6)
    lymphoma 0 3 7927516 (1), 7638185 (1)
    melanoma 0 2 8305739 (1)

    Genetic Association Database (GAD): HCLS1
    Human Genome Epidemiology (HuGE) Navigator: HCLS1 (3 documents)

    Export disorders for HCLS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HCLS1 gene, integrated from 10 sources (see all 132):
    (articles sorted by number of sources associating them with HCLS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain. (PubMed id 15710041)1, 3, 9 van Rossum A.G....Schuuring E. (BMC Genomics 2005)
    2. Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase. (PubMed id 10066823)1, 2, 9 Brunati A.M.... Pinna L.A. (J. Biol. Chem. 1999)
    3. Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis. (PubMed id 15022330)1, 4, 9 Otsuka J....Harada M. (Arthritis Rheum. 2004)
    4. Identification of HS1 protein as a major substrate of protein- tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling. (PubMed id 7682714)1, 2, 9 Yamanashi Y.... Yamamoto T. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    5. The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization. (PubMed id 8978766)1, 3, 9 Egashira M....Niikawa N. (Cytogenet. Cell Genet. 1996)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PubMed id 12522270)1, 2 Salomon A.R.... Peters E.C. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    10. HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. (PubMed id 9058808)1, 2 Suzuki Y....Watanabe T. (J. Immunol. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3059 HGNC: 4844 AceView: HCLS1 Ensembl:ENSG00000180353 euGenes: HUgn3059
    ECgene: HCLS1 Kegg: 3059 H-InvDB: HCLS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HCLS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HCLS1 gene:
    Search GeneIP for patents involving HCLS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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